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<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7YH58</accession>
    <name>C7YH58_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">mRNA export factor MEX67</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_98811</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the export of mRNA from the nucleus to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NXF family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053573.1">
        <property type="nucleotide sequence ID" value="XM_003053527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YH58"/>
    <dbReference type="FunCoup" id="C7YH58">
        <property type="interactions" value="474"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YH58"/>
    <dbReference type="GeneID" id="9664445"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_98811"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98811"/>
    <dbReference type="eggNOG" id="KOG3763">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024991_1_0_1"/>
    <dbReference type="InParanoid" id="C7YH58"/>
    <dbReference type="OMA" id="YGGHEAW"/>
    <dbReference type="OrthoDB" id="25872at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042272">
        <property type="term" value="C:nuclear RNA export factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14342">
        <property type="entry name" value="UBA_TAP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000013">
        <property type="entry name" value="mRNA export factor mex67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000018">
        <property type="entry name" value="Nuclear RNA export factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030217">
        <property type="entry name" value="NXF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005637">
        <property type="entry name" value="TAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662:SF22">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22602">
        <property type="entry name" value="NXF_NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03943">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00804">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51281">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="11">
        <location>
            <begin position="406"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="TAP-C" evidence="12">
        <location>
            <begin position="604"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU47860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="660" mass="71957" checksum="F0301186CC37C765" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7YH95</accession>
    <name>C7YH95_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_31563</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053591.1">
        <property type="nucleotide sequence ID" value="XM_003053545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YH95"/>
    <dbReference type="FunCoup" id="C7YH95">
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    </dbReference>
    <dbReference type="STRING" id="660122.C7YH95"/>
    <dbReference type="GeneID" id="9674464"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_31563"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_31563"/>
    <dbReference type="eggNOG" id="KOG0412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014853_3_0_1"/>
    <dbReference type="InParanoid" id="C7YH95"/>
    <dbReference type="OMA" id="RASECQQ"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013167">
        <property type="entry name" value="COG4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048680">
        <property type="entry name" value="COG4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08318">
        <property type="entry name" value="COG4_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20663">
        <property type="entry name" value="COG4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00762">
        <property type="entry name" value="Cog4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="COG4 transport protein middle alpha-helical bundle" evidence="10">
        <location>
            <begin position="186"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU47878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="801" mass="88725" checksum="5C04E6F7A6081D3E" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHF9</accession>
    <name>C7YHF9_FUSV7</name>
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        <recommendedName>
            <fullName evidence="2">Skg3/CAF120-like PH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_65680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053622.1">
        <property type="nucleotide sequence ID" value="XM_003053576.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9664572"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_65680"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_65680"/>
    <dbReference type="eggNOG" id="ENOG502QPV9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005248_1_1_1"/>
    <dbReference type="InParanoid" id="C7YHF9"/>
    <dbReference type="OMA" id="ASHTWDA"/>
    <dbReference type="OrthoDB" id="5563754at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058155">
        <property type="entry name" value="Skg3/CAF120-like_PH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25381">
        <property type="entry name" value="PH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Skg3/CAF120-like PH-like" evidence="2">
        <location>
            <begin position="133"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1221"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="599"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="799"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="813"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="840"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="868"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="952"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="963"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="984"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="999"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1268"/>
            <end position="1285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU47909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1285" mass="139179" checksum="95AFDB059FB44358" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7YI04</accession>
    <name>C7YI04_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chromosome transmission fidelity protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_75150</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CTF8 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054437.1">
        <property type="nucleotide sequence ID" value="XM_003054391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YI04"/>
    <dbReference type="FunCoup" id="C7YI04">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YI04"/>
    <dbReference type="GeneID" id="9674744"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75150"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75150"/>
    <dbReference type="eggNOG" id="KOG4487">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090690_0_0_1"/>
    <dbReference type="InParanoid" id="C7YI04"/>
    <dbReference type="OMA" id="YLYVGKH"/>
    <dbReference type="OrthoDB" id="121932at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018607">
        <property type="entry name" value="Ctf8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605:SF1">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605">
        <property type="entry name" value="CTF8, CHROMOSOME TRANSMISSION FIDELITY FACTOR 8 HOMOLOG (S. CEREVISIAE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09696">
        <property type="entry name" value="Ctf8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU48724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="15765" checksum="E105BF6B69128ABC" modified="2009-10-13" version="1">MSSASLHPPNKNAKTPSPLPQLLQTPSGLALLELQGVVNMPQTAEGEPASSIEIGRIDFPDYVPDAEGSAWMKRVQLYVGQHQRLTGEVKKLPKAMAVVRRRENGTITGSGGESEEQGDNLEVVEIVKYKIMFSNRPEPVGTANAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7YI08</accession>
    <name>C7YI08_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_102385</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003054393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YI08"/>
    <dbReference type="FunCoup" id="C7YI08">
        <property type="interactions" value="1130"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YI08"/>
    <dbReference type="GeneID" id="9674746"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102385"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102385"/>
    <dbReference type="eggNOG" id="KOG3283">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080597_1_1_1"/>
    <dbReference type="InParanoid" id="C7YI08"/>
    <dbReference type="OMA" id="QRPHYRK"/>
    <dbReference type="OrthoDB" id="1703270at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11380">
        <property type="entry name" value="Ribosomal_S8e_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.168.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.70:FF:000001">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.168.20">
        <property type="entry name" value="Ribosomal protein S8e, subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_eS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042563">
        <property type="entry name" value="Ribosomal_protein_eS8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU48726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="206" mass="23182" checksum="99FCB9621406B414" modified="2009-10-13" version="1">MGISRDSRHKRSASGAKRAYYRKKRAFEAGRQGANTRIGPKRVHTVRTRGGNHKYRALRLDSGNFAWGSEGCTRKTRVIGVAYHPSNNELVRTNTLTKSAVVQIDAAPFRQWYEAHYGQPIGRRRQKAQAAKEGKTEEEVKKSNAVEKKQAARHAARGKVESAVEKQFEAGRLFAVISSRPGQSGRCDGYILEGEELAFYQRKLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJK9</accession>
    <name>C7YJK9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_30952</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054005.1">
        <property type="nucleotide sequence ID" value="XM_003053959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJK9"/>
    <dbReference type="GeneID" id="9676629"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_30952"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_30952"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="InParanoid" id="C7YJK9"/>
    <dbReference type="OMA" id="VAEGKWH"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="13"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU48292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="507" mass="55419" checksum="EBCCB03B67AE91DA" modified="2009-10-13" version="1">MRSDAWLSKPFLTAIFLGIGGFLYGFDSGIITPSLALNSFLTYFGNPHAALRGAIVSVYQAGAWLGSASVGVTSDRLGRRKAIAFGCIWGVIGGALMAGAAHVAMLIMGRLLIGFAVGTITGVAPVFGAEIAKARPLPNSPQTNERAKITAVNQMMVAWGFFVALWTGVGEGKWHNPNQWRLGFAIQSIPALLLGVGVLFLSESPRWLCLKGRYEEAEKAFRNYHYDGTNDEWCRTEFTVIQVNIAEELQAQGKLSWADLIKTSAFRKRLFVGSFVWAAAMLSGISFVQYYQTAIYATLQFDQDRQLLVSGLYGSVAPVACFLSLFFVDKIGRRKILVISSSLLSLCYMIITILAALYPARPGLPTNAAAQRGLIACIFAVSANYSALLGPMTWIIPPEVFTTELRAKANAIVQVVHYSISLIITQCSPIALAEVGWKYYILFVLTNALCAVVFAFAYPETRGKSLEEIDEIFGDVKVIRQEDVKFSEKAGLETLEYRGNRTSAQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7YK02</accession>
    <name>C7YK02_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine protease</fullName>
            <ecNumber evidence="6">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_74437</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S1B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="6"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053368.1">
        <property type="nucleotide sequence ID" value="XM_003053322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YK02"/>
    <dbReference type="STRING" id="660122.C7YK02"/>
    <dbReference type="GeneID" id="9664008"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74437"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74437"/>
    <dbReference type="eggNOG" id="ENOG502SN2K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025889_0_0_1"/>
    <dbReference type="InParanoid" id="C7YK02"/>
    <dbReference type="OMA" id="MGSGWLI"/>
    <dbReference type="OrthoDB" id="3693942at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050966">
        <property type="entry name" value="Glutamyl_endopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008256">
        <property type="entry name" value="Peptidase_S1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15462">
        <property type="entry name" value="SERINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15462:SF8">
        <property type="entry name" value="SERINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00839">
        <property type="entry name" value="V8PROTEASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU47655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="786" mass="83146" checksum="4B76B2211EE26EAA" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7YKI4</accession>
    <name>C7YKI4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_74621</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053454.1">
        <property type="nucleotide sequence ID" value="XM_003053408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YKI4"/>
    <dbReference type="STRING" id="660122.C7YKI4"/>
    <dbReference type="GeneID" id="9664179"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74621"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74621"/>
    <dbReference type="eggNOG" id="ENOG502SV9S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055491_6_1_1"/>
    <dbReference type="InParanoid" id="C7YKI4"/>
    <dbReference type="OMA" id="WCQRESG"/>
    <dbReference type="OrthoDB" id="406544at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF33">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="14"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="116"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU47741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="221" mass="24231" checksum="8794D56A1AC06618" modified="2009-10-13" version="1">MSTHYSEKDIFPLAGGCACGLIRYRFNLPPIIVHACYCTACQRQTGTALALNAVIESSAIEILPSASPTVAGLPASPEPVQAGVAPAFARITAAEDPTREPRPSADTVAVCLPSESGLGQTIASCPACRTGLWTHYADAGRHLYYIRVGTLDQPWQIEPDVHIYTRSRPAWLAANDGKPSFEEYYPDRRPLLREDALKRFETYRLKAQEMWAELKPALGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7YKZ7</accession>
    <name>C7YKZ7_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_77350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052877.1">
        <property type="nucleotide sequence ID" value="XM_003052831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YKZ7"/>
    <dbReference type="GeneID" id="9671408"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77350"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77350"/>
    <dbReference type="eggNOG" id="ENOG502T6A5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_582759_0_0_1"/>
    <dbReference type="InParanoid" id="C7YKZ7"/>
    <dbReference type="OrthoDB" id="5427329at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU47164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="469" mass="53794" checksum="6BF5C009F1FB9D89" modified="2009-10-13" version="1">MTMLGETGTNPIRRFISFKDQEACKILNEILFEVGKRDLMIQGSLEAEDRGELGLKLTQMEFDQAAAMEFRRRKITEALKQKRLQGLDSQVKTYDFFYGQTTIKVALSDAKMAAASGKRASQLTQAAAMGGFSASDIASGLGWEQKRLSSGFFSSEWLLLAAFSWGGFMSPGEKSGFSTSQNLENLVFGTCETNSLMKRYEMAWQDFYRKEQKLHNKLAAARNEKAISVHGLLEIRCNDFSSEDPSSRFIRCDVYTHDNKYKLKDFTIDKSLVEEVLRKAEENIKNDPPQTMSDLYNSMRDNTPTHCQDSRTPDKFTSEAEMLLLAHDFPCVVYSIQYKIVNEFKSILLNDMACAHFSFFPFQRSLYHQAEAVLDALVWKEIKDKADTWPEGRDDDIEFEPRSKRRQDPNDAGRRSTLFDQDRDEEMGQRREKPKQKRNNVFNIIKYGGFIKPHRKTVKKAVKGGNQDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLS3</accession>
    <name>C7YLS3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_36647</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052537.1">
        <property type="nucleotide sequence ID" value="XM_003052491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YLS3"/>
    <dbReference type="FunCoup" id="C7YLS3">
        <property type="interactions" value="219"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YLS3"/>
    <dbReference type="GeneID" id="9671069"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_36647"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_36647"/>
    <dbReference type="eggNOG" id="KOG2454">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_1"/>
    <dbReference type="InParanoid" id="C7YLS3"/>
    <dbReference type="OMA" id="ILMRGTF"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07098">
        <property type="entry name" value="ALDH_F15-22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000014">
        <property type="entry name" value="aldehyde dehydrogenase 22A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000024">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="91"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU46824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="613" mass="65925" checksum="014DA9A89FCD6FFE" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLU0</accession>
    <name>C7YLU0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Outer spore wall protein RRT8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_58982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052545.1">
        <property type="nucleotide sequence ID" value="XM_003052499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YLU0"/>
    <dbReference type="FunCoup" id="C7YLU0">
        <property type="interactions" value="78"/>
    </dbReference>
    <dbReference type="GeneID" id="9663811"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_58982"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_58982"/>
    <dbReference type="eggNOG" id="ENOG502QVX4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062645_0_0_1"/>
    <dbReference type="InParanoid" id="C7YLU0"/>
    <dbReference type="OMA" id="GRYFQLK"/>
    <dbReference type="OrthoDB" id="10012223at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005619">
        <property type="term" value="C:ascospore wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052786">
        <property type="entry name" value="Spore_wall_assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292:SF2">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU46832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="32336" checksum="BDC373F921983A65" modified="2009-10-13" version="1">MVDSVGEKAQEVFKEDYAQAKEHVAHAAKSKAYLYPIKARLGIVYLIAHRSLWAPFLSKLGPLILLSTGVIGGMFAFTYLPQLAVLVFVNGPLAVVTTSLLVLNESTTIINLISRNYLLQDALLDTFDGTLLTRGDTQIVSEGREVKSGSDPMQKLGKILKSPFEKFSPKAIIRYVMYLPLNAIPVVGTAIFIALQGRNRGKGVHDRYFQLKQWSAPKRSDWLNKNVGPYTAFGLVATLLEMIPVASMFFTFTNTGESSKDVGAALWAADIEDKNTTMTDETAPSLRETAEKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7YMH4</accession>
    <name>C7YMH4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_67475</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053161.1">
        <property type="nucleotide sequence ID" value="XM_003053115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YMH4"/>
    <dbReference type="FunCoup" id="C7YMH4">
        <property type="interactions" value="316"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YMH4"/>
    <dbReference type="GeneID" id="9671195"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_67475"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_67475"/>
    <dbReference type="eggNOG" id="KOG1589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099502_0_1_1"/>
    <dbReference type="InParanoid" id="C7YMH4"/>
    <dbReference type="OMA" id="FRQNFYQ"/>
    <dbReference type="OrthoDB" id="869189at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU47448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="173" mass="19537" checksum="C7FE687B0B2E0EFF" modified="2009-10-13" version="1">MSSTTVFRASRPLFRQATTTFGGAPARQAFRQNFRQGSGRRWQSTDGAQQQQQSWFNRMWESEVGFKTVHFWAPVMKWALVLAGISDFARPAEKLSFTQNLALTCTGIIWTRWCLIIKPKNYLLAAVNFFLGLVGLVQITRIAKYESDKKAGLKGAIEDIKADAKETVKEIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7YMS6</accession>
    <name>C7YMS6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Elongation factor 1-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_59329</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053209.1">
        <property type="nucleotide sequence ID" value="XM_003053163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YMS6"/>
    <dbReference type="FunCoup" id="C7YMS6">
        <property type="interactions" value="1663"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YMS6"/>
    <dbReference type="GeneID" id="9671249"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_59329"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_59329"/>
    <dbReference type="eggNOG" id="KOG0052">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_3_5_1"/>
    <dbReference type="InParanoid" id="C7YMS6"/>
    <dbReference type="OMA" id="AIRDMGM"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000003">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000211">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="10 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="6"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU47496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="460" mass="49875" checksum="3A27A0B982CC3EDD" modified="2009-10-13" version="1">MGKEDKTHLNVVVIGHVDSGKSTTTGHLIYQCGGIDKRTIEKFEKEAAELGKGSFKYAWVLDKLKAERERGITIDIALWKFETPRYYVTVIDAPGHRDFIKNMITGTSQADCAILIIAAGTGEFEAGISKDGQTREHALLAYTLGVKNLIVAINKMDTTKWSESRFQEIIKETSNFIKKVGYNPKAVAFVPISGFNGDNMLTPSTNCPWYKGWEREIKSGKLTGKTLLEAIDSIEPPKRPVDKPLRLPLQDVYKIGGIGTVPVGRIETGVIKPGMVVTFAPSNVTTEVKSVEMHHEQLTEGLPGDNVGFNVKNVSVKEIRRGNVAGDSKNDPPLGAASFTAQVIVLNHPGQVGAGYAPVLDCHTAHIACKFAEIQEKIDRRTGKAVESAPKFIKSGDSAIVKMVPSKPMCVEAFTDYPPLGRFAVRDMRQTVAVGVIKAVEKAAAGSGKVTKSAAKAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7YMY9</accession>
    <name>C7YMY9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_78045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053244.1">
        <property type="nucleotide sequence ID" value="XM_003053198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YMY9"/>
    <dbReference type="GeneID" id="9664235"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78045"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78045"/>
    <dbReference type="HOGENOM" id="CLU_1250978_0_0_1"/>
    <dbReference type="InParanoid" id="C7YMY9"/>
    <dbReference type="OrthoDB" id="3594103at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU47531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="25368" checksum="5450FB646EFF65B9" modified="2009-10-13" version="1">MEARGTGENTSQRVQSMVMLVLAGPKVLLLPEKTIDKYPDFATRFVTVPDGKKLDLTTWPTGVVHVLVMFLFTGTYQDLHELGKDELELYDEPEAMLHRVLQTYLLATLCGLDRLIQLAVHVFDVTSRSMSLPGVLLVLSGSNVTFDNEHFELMHNLVQRASRVGWEAELDEGLGTYRLALKNDGTIFGALFSHILEQRARIRDLMHENERLTDRLDSERWLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7YN83</accession>
    <name>C7YN83_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_17696</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MATALPHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052790.1">
        <property type="nucleotide sequence ID" value="XM_003052744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YN83"/>
    <dbReference type="GeneID" id="9671322"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_17696"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_17696"/>
    <dbReference type="eggNOG" id="ENOG502S4ZK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1232459_0_0_1"/>
    <dbReference type="InParanoid" id="C7YN83"/>
    <dbReference type="OrthoDB" id="5398665at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008301">
        <property type="term" value="F:DNA binding, bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045895">
        <property type="term" value="P:positive regulation of mating-type specific transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006856">
        <property type="entry name" value="MATalpha_HMGbox"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04769">
        <property type="entry name" value="MATalpha_HMGbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51325">
        <property type="entry name" value="ALPHA_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Alpha box" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU47077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="225" mass="25504" checksum="6C634C146D78B2A9" modified="2009-10-13" version="1" fragment="single">VGRTKRPLNAFMAFRTYYLKMFPDVQQKTVSGFLTTLWNKEAQRNKWALIAKVYSFVRDHLGKAKVNLAAFLALCCPIMRMIDPADYLDTLGWVVQENTEGAMTITQVQDDEHSVESTSSPDAYPTSEIELLASLVESGYLPEYGPALVQLMSQNNNGMMTLSVDKVDKKKEFIDALVKNPYQATEQILGPVYDHAYFQRMSVYSWETVDLGDFSHIPITIPYPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNH0</accession>
    <name>C7YNH0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase family 43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_35135</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053338.1">
        <property type="nucleotide sequence ID" value="XM_003053292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNH0"/>
    <dbReference type="GeneID" id="9671364"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_35135"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_35135"/>
    <dbReference type="eggNOG" id="ENOG502QTYK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009397_4_1_1"/>
    <dbReference type="InParanoid" id="C7YNH0"/>
    <dbReference type="OMA" id="TEDIPWV"/>
    <dbReference type="OrthoDB" id="5211809at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18619">
        <property type="entry name" value="GH43_CoXyl43_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052176">
        <property type="entry name" value="Glycosyl_Hydrlase_43_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772:SF2">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU47625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="327" mass="36725" checksum="277636244581E920" modified="2009-10-13" version="1">MAPLITNIYTADPSAHVFNGKVYIYPSHDRETDIKFNDNGDQYDMADYHVFSTDSLSPPGEVTDHGVVLKMEDVPWVSKQLWAPDAAEKNGKYYLYFPARDKKGIFRLGVAVGDKPEGPFTPDPEPIKGSYSIDPASFVDDDGQAYLYFGGLWGGQLQCYQKGNDIFDPEWQGPKEVSGEGVIAQGPRVGKLTEDMYQFEGEVQEITILAPETGKPILGDDHDRRFFEAAWVHKRGDTYYFSYSTGDTHFLCYATGKSPLGPFTYGGRILEPVLGWTTHHSIVEFKGKTYLFHHDCELSKGVDHLRSVKVKEIFYDDEGKIITTTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNW7</accession>
    <name>C7YNW7_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_79450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051901.1">
        <property type="nucleotide sequence ID" value="XM_003051855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNW7"/>
    <dbReference type="GeneID" id="9670883"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79450"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79450"/>
    <dbReference type="HOGENOM" id="CLU_897385_0_0_1"/>
    <dbReference type="InParanoid" id="C7YNW7"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU46188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="310" mass="33925" checksum="168997ED59D6FD7B" modified="2009-10-13" version="1">MSEWRSSKVEWTSNVDKAPGQSRARPKETTGRVGRAPGPEPRGRLALKWYPRCTWISFTCASSPRPPPPHTACATRCSMPGWAAVCVTVRTLDALLAHASPGLYYSASAPSVAGLCGDPSSSRSRLRRWPHGLASIRRWTAARSIRVCSSLIPSAFLFLLLLLLAARLLWHCTICTAHGLVERNRVDQAPPKGGKLLALADGLGQVHFALELFYEGRSSARIIGRILISGALELEGQPRTKSRGSSREGQFKLKEDLTIKANQPSDSFVDGVSLSIQTRKRDTLPNAQRSTNKAPQSLARVQTPRSERKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNX8</accession>
    <name>C7YNX8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4484 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_92979</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052365.1">
        <property type="nucleotide sequence ID" value="XM_003052319.1"/>
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    <dbReference type="AlphaFoldDB" id="C7YNX8"/>
    <dbReference type="FunCoup" id="C7YNX8">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YNX8"/>
    <dbReference type="GeneID" id="9672987"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_92979"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_92979"/>
    <dbReference type="eggNOG" id="KOG4704">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019791_0_0_1"/>
    <dbReference type="InParanoid" id="C7YNX8"/>
    <dbReference type="OMA" id="GYTIVWK"/>
    <dbReference type="OrthoDB" id="2152680at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028115">
        <property type="entry name" value="DUF4484"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018626">
        <property type="entry name" value="LCHN/Anr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053056">
        <property type="entry name" value="Lipid_Metab_Assoc_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28153:SF1">
        <property type="entry name" value="DUF4484 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28153">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09804">
        <property type="entry name" value="DENND11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14831">
        <property type="entry name" value="DUF4484"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4484" evidence="2">
        <location>
            <begin position="421"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU46652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="616" mass="67975" checksum="E0BB4CC4999418AF" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNZ4</accession>
    <name>C7YNZ4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">NECHADRAFT_1180</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
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        <property type="protein sequence ID" value="EEU46663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052376.1">
        <property type="nucleotide sequence ID" value="XM_003052330.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="C7YNZ4">
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    </dbReference>
    <dbReference type="STRING" id="660122.C7YNZ4"/>
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    <dbReference type="KEGG" id="nhe:NECHADRAFT_1180"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_1180"/>
    <dbReference type="eggNOG" id="KOG0338">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_3_1_1"/>
    <dbReference type="InParanoid" id="C7YNZ4"/>
    <dbReference type="OMA" id="MIDPPKQ"/>
    <dbReference type="OrthoDB" id="10259843at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="DEADc_DDX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="255"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="286"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="493"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="124"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="690"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="636"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="255"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="690"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="724"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="755"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEU46663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="768" mass="85383" checksum="8EC2C68BBA51419F" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPI4</accession>
    <name>C7YPI4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_78765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051562.1">
        <property type="nucleotide sequence ID" value="XM_003051516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YPI4"/>
    <dbReference type="STRING" id="660122.C7YPI4"/>
    <dbReference type="GeneID" id="9668639"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78765"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78765"/>
    <dbReference type="eggNOG" id="ENOG502RJRP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142375_0_0_1"/>
    <dbReference type="InParanoid" id="C7YPI4"/>
    <dbReference type="OMA" id="DIDWHAV"/>
    <dbReference type="OrthoDB" id="5403747at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU45849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15525" checksum="A9217EF52A4D08BD" modified="2009-10-13" version="1">MSDTKKEPTAAEAMLFFSIVKHTRNKADVDWDSVALEAGFKNADVAKVRFGQVKRKLGISTDTGVAPRAPTTPTKKGAFRVAKTPRSTTKGKGRSRVKKEEEKPAEAEEDEDQKMEMEQPIVKDEQQDELSADNTKADPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPI6</accession>
    <name>C7YPI6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_78767</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051564.1">
        <property type="nucleotide sequence ID" value="XM_003051518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YPI6"/>
    <dbReference type="GeneID" id="9668641"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78767"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78767"/>
    <dbReference type="eggNOG" id="ENOG502SFTJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114593_2_0_1"/>
    <dbReference type="InParanoid" id="C7YPI6"/>
    <dbReference type="OMA" id="EFCNTGA"/>
    <dbReference type="OrthoDB" id="5353914at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054505">
        <property type="entry name" value="Myb_DNA-bind_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22980">
        <property type="entry name" value="Myb_DNA-bind_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like DNA-binding" evidence="2">
        <location>
            <begin position="7"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU45851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="149" mass="15747" checksum="1543DED7CCCCA671" modified="2009-10-13" version="1">MSKQDPADQVKFLVSCIGHTSNGRPDFQAVADELSIVSKAAAQKRYERMLKAHGISRPGVLAGGDSVPTTPTKRKAKGEGAGSAKKKPARGKAKKESDEDEEAEAKPKPKAKRGKQADKVKKEEEESDSGESRGSSLTEPPAASEEGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQU4</accession>
    <name>C7YQU4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ABC transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NECHADRAFT_104160</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052249.1">
        <property type="nucleotide sequence ID" value="XM_003052203.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9673702"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_104160"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_104160"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_17_2_1"/>
    <dbReference type="InParanoid" id="C7YQU4"/>
    <dbReference type="OMA" id="GFGQEEQ"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000102">
        <property type="entry name" value="ABC multidrug transporter Mdr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000009">
        <property type="entry name" value="ABC transporter B family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000251">
        <property type="entry name" value="ABC transporter B family member 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000302">
        <property type="entry name" value="ATP-binding cassette subfamily B member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="731"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="778"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="849"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="881"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="963"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="995"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="84"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="410"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="733"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1059"/>
            <end position="1297"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU46536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1304" mass="142917" checksum="4D6AE8582D6F2345" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7YR13</accession>
    <name>C7YR13_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_104179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003051783.1"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF104">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="42"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU46116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="629" mass="72666" checksum="D30E7EE7C94C7F8D" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRL1</accession>
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        <recommendedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase/oxidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_61163</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050806.1">
        <property type="nucleotide sequence ID" value="XM_003050760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YRL1"/>
    <dbReference type="STRING" id="660122.C7YRL1"/>
    <dbReference type="GeneID" id="9667888"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_61163"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_61163"/>
    <dbReference type="eggNOG" id="KOG0137">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016513_1_1_1"/>
    <dbReference type="InParanoid" id="C7YRL1"/>
    <dbReference type="OMA" id="FQGAMFM"/>
    <dbReference type="OrthoDB" id="10251155at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052904">
        <property type="entry name" value="Acyl-CoA_dehydrogenase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707:SF2">
        <property type="entry name" value="ACD11 DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="6">
        <location>
            <begin position="192"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="5">
        <location>
            <begin position="324"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU45093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="636" mass="70184" checksum="60A170F9AF794DA6" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7YS49</accession>
    <name>C7YS49_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_41715</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050898.1">
        <property type="nucleotide sequence ID" value="XM_003050852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YS49"/>
    <dbReference type="FunCoup" id="C7YS49">
        <property type="interactions" value="788"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YS49"/>
    <dbReference type="GeneID" id="9666066"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_41715"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_41715"/>
    <dbReference type="eggNOG" id="KOG1871">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008279_3_0_1"/>
    <dbReference type="InParanoid" id="C7YS49"/>
    <dbReference type="OMA" id="AMIMFMK"/>
    <dbReference type="OrthoDB" id="429671at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="494"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="133"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="607"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="831"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="189"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="320"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="833"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="887"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU45185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="920" mass="99011" checksum="19862E867C5E7B63" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSA8</accession>
    <name>C7YSA8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_80671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051315.1">
        <property type="nucleotide sequence ID" value="XM_003051269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSA8"/>
    <dbReference type="GeneID" id="9668162"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_80671"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_80671"/>
    <dbReference type="eggNOG" id="ENOG502SXT7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070615_2_0_1"/>
    <dbReference type="InParanoid" id="C7YSA8"/>
    <dbReference type="OMA" id="REYHCED"/>
    <dbReference type="OrthoDB" id="2687452at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="145"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU45602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="236" mass="27365" checksum="6A0C9E0372881C7B" modified="2009-10-13" version="1">MSYYGQQSNYFYDASDSQDQATSPAAYQHDSYSWPLARGVSSGGSSTASTVPESPMQSGYYSAQQQDPAYQQGPAYPQDSTYQDSYYSAYSAGSEDTNVPRGDGHSGPDNMCLAPGCNAKPFKRTADLQRHYRNIHNPDLTKEAHFCDYPKCTRASEPFRRRDHFRDHLREYHREDIQKRGVVVNEEWLEDRYYSDKWWRCPRCLIRVYTSKDEYECPKCKGSCEPKRKEKRRSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C7YTL2</accession>
    <name>C7YTL2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_84621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050355.1">
        <property type="nucleotide sequence ID" value="XM_003050309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YTL2"/>
    <dbReference type="GeneID" id="9675140"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84621"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84621"/>
    <dbReference type="HOGENOM" id="CLU_2264434_0_0_1"/>
    <dbReference type="InParanoid" id="C7YTL2"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU44642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="103" mass="11452" checksum="48F2FC37A660C498" modified="2009-10-13" version="1">MVRYARQLVRFSSNPCRSGTGTGPRVLCGVVDGRDVREILVATQGDILLAFWISGTIWGYAESALVIGPIVINSQAGEYLKTLEDIWEHWQQELKNDNGDDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7YW16</accession>
    <name>C7YW16_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ca2+ transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_65123</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049809.1">
        <property type="nucleotide sequence ID" value="XM_003049763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YW16"/>
    <dbReference type="FunCoup" id="C7YW16">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="GeneID" id="9677175"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_65123"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_65123"/>
    <dbReference type="eggNOG" id="KOG1397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001583_0_0_1"/>
    <dbReference type="InParanoid" id="C7YW16"/>
    <dbReference type="OMA" id="PQWDMIT"/>
    <dbReference type="OrthoDB" id="16982at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000017">
        <property type="entry name" value="Calcium permease family membrane transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF10">
        <property type="entry name" value="VNX1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="421"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="541"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="573"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="609"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="641"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="712"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="925"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="959"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="994"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1033"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1059"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="domain" description="Inner membrane component" evidence="11">
        <location>
            <begin position="270"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="543"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="924"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="374"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="794"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="870"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="802"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU44096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1117" mass="123462" checksum="6266055EB6BB49D3" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7YX24</accession>
    <name>C7YX24_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_82867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049470.1">
        <property type="nucleotide sequence ID" value="XM_003049424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YX24"/>
    <dbReference type="STRING" id="660122.C7YX24"/>
    <dbReference type="GeneID" id="9676901"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82867"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82867"/>
    <dbReference type="eggNOG" id="ENOG502SRFM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_468580_0_0_1"/>
    <dbReference type="InParanoid" id="C7YX24"/>
    <dbReference type="OMA" id="RNTSEYH"/>
    <dbReference type="OrthoDB" id="5865767at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="555"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU43757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="582" mass="63402" checksum="3A248B8F28A767F4" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7YX72</accession>
    <name>C7YX72_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_95080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049247.1">
        <property type="nucleotide sequence ID" value="XM_003049201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YX72"/>
    <dbReference type="GeneID" id="9676925"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95080"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95080"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_6_0_1"/>
    <dbReference type="InParanoid" id="C7YX72"/>
    <dbReference type="OMA" id="DMFEIPR"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF115">
        <property type="entry name" value="DEHYDROGENASE XPTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988756" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="5">
        <location>
            <begin position="18"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="534"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="577"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU43534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="600" mass="64362" checksum="1F880F5E6DA093C7" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXG6</accession>
    <name>C7YXG6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_94917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049049.1">
        <property type="nucleotide sequence ID" value="XM_003049003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXG6"/>
    <dbReference type="STRING" id="660122.C7YXG6"/>
    <dbReference type="GeneID" id="9666281"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94917"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94917"/>
    <dbReference type="eggNOG" id="KOG1199">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="InParanoid" id="C7YXG6"/>
    <dbReference type="OMA" id="QGLFHEI"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF45">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G09150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU43336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="242" mass="24720" checksum="DC7D78C3827D847A" modified="2009-10-13" version="1">MPPSSQPVEQSKSFAITSAASNIGLATAKLLARRGALLSLADLSLPRLEAARSSLGGDNERHIITAVDVKSSSAVSAWIQDTVKWFGGLDGCVNVAGFCGPHRYIVMGVNATGAFNCTRAALSVMGAGGSLVNVTSAGGLQGLVGMGAYCASKHAVIGLSKTAAKEMGSKNVRVNCVAPSTIDTPMVKDMEASIGTSLTASHQALDRKADPSEVANVIEFLLSDEASFVTGAVYSVAGGWMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7YY74</accession>
    <name>C7YY74_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine amidotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_73803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048853.1">
        <property type="nucleotide sequence ID" value="XM_003048807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YY74"/>
    <dbReference type="FunCoup" id="C7YY74">
        <property type="interactions" value="118"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YY74"/>
    <dbReference type="GeneID" id="9667793"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_73803"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_73803"/>
    <dbReference type="eggNOG" id="KOG3179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054974_0_2_1"/>
    <dbReference type="InParanoid" id="C7YY74"/>
    <dbReference type="OMA" id="PWIQTLK"/>
    <dbReference type="OrthoDB" id="92161at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="63"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU43140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="253" mass="27963" checksum="FF2D88BAF56F7739" modified="2009-10-13" version="1">MGSAAPLRLAILEADTPQPQTRDRYGGYTGVFTALLNAAANSLKPPQKLDEIVTIKGYDVVNELHSYPALEDIDAILITGSRHTAFDNDPWILKLVEYTKKAIETDRVRVVGICFGHQIIGRAAGAKLGRSDKGWEVAVTEVDLTAKGKEIFGLDKMRIHQMHRDIVSEFPPNSIPLGSNAICEVQAFYSPGRYISVQGHPEFTDEIISEVLFNRHTVGIFSDELYADAMKRAPIPHDGVAIARAFLKFMREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYN5</accession>
    <name>C7YYN5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_95505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048934.1">
        <property type="nucleotide sequence ID" value="XM_003048888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYN5"/>
    <dbReference type="STRING" id="660122.C7YYN5"/>
    <dbReference type="GeneID" id="9665520"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95505"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95505"/>
    <dbReference type="eggNOG" id="ENOG502S728">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019419_2_0_1"/>
    <dbReference type="InParanoid" id="C7YYN5"/>
    <dbReference type="OMA" id="WPENILR"/>
    <dbReference type="OrthoDB" id="2351940at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU43221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="539" mass="61625" checksum="85F3CA1038A37536" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYS1</accession>
    <name>C7YYS1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_83785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048956.1">
        <property type="nucleotide sequence ID" value="XM_003048910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYS1"/>
    <dbReference type="GeneID" id="9665953"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83785"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83785"/>
    <dbReference type="eggNOG" id="ENOG502SWAM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065394_0_0_1"/>
    <dbReference type="InParanoid" id="C7YYS1"/>
    <dbReference type="OMA" id="MEGSWWD"/>
    <dbReference type="OrthoDB" id="5118341at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU43243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="35962" checksum="E8535DFDBFDCFCBF" modified="2009-10-13" version="1">MMKSIERKRGSTDEHILAVVRARSVEGLLEKYNQSQPSSRKLIGKSKERAAVTVTCLDHLQAWIEHITNIIKCRKIKIIVSCLVDDLNMHIEKRVRKLELYRCGYGENADLNNFVTGWSTYRGIRFDEWDGQGDKELWFGPGIAIKVDPRRSNLWSPKDSSFTVNNEDKDTLRRYFEGLQSIPMEGDWWQKWKSAISLILGVLGGGAKLAVSMNVTAAGAYIHYQSWTGSSVKLGCGGMKASMEASGGAVLVGAGVAAAVYFIPWDVVLGWMDSLFSWLWEGFKSMMNKFWEWMKSFWASNPTKEQQMQVGIPRPMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYU4</accession>
    <name>C7YYU4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_62851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048772.1">
        <property type="nucleotide sequence ID" value="XM_003048726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYU4"/>
    <dbReference type="FunCoup" id="C7YYU4">
        <property type="interactions" value="1068"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YYU4"/>
    <dbReference type="GeneID" id="9665966"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_62851"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_62851"/>
    <dbReference type="eggNOG" id="KOG0092">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_10_2_1"/>
    <dbReference type="InParanoid" id="C7YYU4"/>
    <dbReference type="OMA" id="GASFFRY"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000611">
        <property type="entry name" value="RAB GTPase Vps21/Ypt51, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU43059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="236" mass="24800" checksum="A20A51C40DA047EE" modified="2009-10-13" version="1">MADSANAPKPSSSVKLVLLGEAAVGKSSLVLRFVNNDFQENKEPTIGAAFLTQKCNLPTRTIKFEIWDTAGQERFASLAPMYYRNAQAALVVYDLTKPTSLIKAKHWVAELQRQASPGIVIALVGNKLDLTGDSGAAADSQNGDDGEESGDARKVSTEEAQSYAEEESLLFFETSAKSGHNVTEVFTAIANAIPETSLKSARGAGATSGAASRGGEEQRVNLGGPKDAAAKDSCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZ62</accession>
    <name>C7YZ62_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_46641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048835.1">
        <property type="nucleotide sequence ID" value="XM_003048789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZ62"/>
    <dbReference type="GeneID" id="9666096"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_46641"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_46641"/>
    <dbReference type="eggNOG" id="ENOG502S27H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_783134_0_0_1"/>
    <dbReference type="InParanoid" id="C7YZ62"/>
    <dbReference type="OMA" id="ACSVAQY"/>
    <dbReference type="OrthoDB" id="4159838at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU43122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="349" mass="37921" checksum="7B0C5055966E5BB3" modified="2009-10-13" version="1" fragment="single">MCLRKVPAALAAIEAWDEQIAEEEGNRFKWESSKASTELYGQLEGFGATGLGWKPLKLVVRAHALSLLAGAVSEGLFEPPFVRLLAELCISLESSEEAARLVSSLDCPLAAPRSSSSTLVESNTVQPLGVIVKSLHNQRSFGAAFECLSSLVRTKKLSLSWLTSRAFQVVWTRGIEVLNSSSPAPSAIDFICTAIDQLASHEGKKSGAEKNPEEQTLVSVLAALTAAAWTLGTEMCDTTGPWRKQGARRMLHVLECCVVQQQKRRGAFRSNGLFTLALARFIATAMIDSDVIDLTAKQQASQECSRLLTVGNGTPSRWQYRQTLLMACFVAQYRGRACALACHDVLSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0F3</accession>
    <name>C7Z0F3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_79873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047904.1">
        <property type="nucleotide sequence ID" value="XM_003047858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0F3"/>
    <dbReference type="STRING" id="660122.C7Z0F3"/>
    <dbReference type="GeneID" id="9667258"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79873"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79873"/>
    <dbReference type="eggNOG" id="ENOG502SN1P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_733822_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z0F3"/>
    <dbReference type="OMA" id="FVIADQP"/>
    <dbReference type="OrthoDB" id="4159781at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="377" mass="42108" checksum="0F4E9AF1045A951B" modified="2009-10-13" version="1">MPKEWRFVVSNRPSALKAKAASIRGHAACQGWKAHKKPRGQKRRRGLPPLKKTTYEYVAVDMPSCWFPPIEYQLGGGRVDPFRAYPGSQHPAIPALVDHYLIHMAVNIPELDQPGNAGLLRSSWFPLVISNECPFKVILLLAASNAVAINYKPYASCDLVQLHTNAIKAINNAFDSNEKRVCDALIGAVAKMASFEAMHGDVGSYRIHMEGLCKMIALRGGLDQLGLDGLLRRIVVWIDINSSFLLQIPRYFPQDGFVVGEDFYRAGGLDEISSLLLKDGGILPYSLSHCRMPRHPYYLEDPVEEVLLLMYRQDLHEHTLRSLVAVRPLIEAAKSSMDCSSSVRFASCQGLQVTHLRQFRKINISRSSTVLQAIMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0N3</accession>
    <name>C7Z0N3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_79953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048125.1">
        <property type="nucleotide sequence ID" value="XM_003048079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0N3"/>
    <dbReference type="GeneID" id="9667297"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79953"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79953"/>
    <dbReference type="eggNOG" id="ENOG502T4CT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_608451_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z0N3"/>
    <dbReference type="OMA" id="TCKEDAV"/>
    <dbReference type="OrthoDB" id="5051549at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU42412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="440" mass="49849" checksum="74E7A73C261E9203" modified="2009-10-13" version="1">MATLPVLQHEWKTAPVMGSDFVPFETPRHVFSNDAQLFANEVTGMLIQIHQIAIVLTDEIGKFNQSRCWTDQDEHIDLVFKPEHFVASVRYFNLICEEAIDSIEALDGRLSAKPWLMSDAITNPPHDLRAMLAITKEVHQEAQYAEQNLVINMGLSNSQCAALDDINKPELHAVPAASPREIRFWVTWNTKTRLRRLSNEIDSGNVMEFYHELEASLINENSRDSPYPLRKPLPGKQMLKDKKKSRLFNPMTYFFCLGVDSAGSRVHEMIHIGATQERLQPWAAFWRIRRDSRLVRTGGDAERWANFFSGLIHVERHILAKTNPRLELNAFRTQIMEWRLGLRANPPAGTDSEDYRHIPVLRSCGGHVGQSFQPQDEGPVPCCLACKLSIGYKECTDPEITQSADFNLPGRAKTAWSCAEVISSKYCAVKTSVSSSKDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z157</accession>
    <name>C7Z157_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_80121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="nhe:NECHADRAFT_80121"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_80121"/>
    <dbReference type="eggNOG" id="ENOG502SIH6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2991872at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU42512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="22111" checksum="B18F55ED6199AAE4" modified="2009-10-13" version="1">MSDLQNAAHQAKPICQKCIKSHRTCVEANAAKQQLFAIHIENQYAAGEKRRPRGPRSSLVPIQANVDLKTRAHAYYVQHHFQVFPDMPNVALTWAECLHEWKAGGKSSPIVDLAFSAVALSVFARFQNCRPAAAEASQSYLSLLRHMQDRIPRLSSGILSSDEIDEYLLGAHFMARYEAFVQNHGEKTDLEPLKEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
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    <name>C7Z194_FUSV7</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">NECHADRAFT_39965</name>
    </gene>
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        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
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        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
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            <taxon>Sordariomycetes</taxon>
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        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
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                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
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                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
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            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z194"/>
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    <dbReference type="GeneID" id="9672022"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_39965"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_39965"/>
    <dbReference type="eggNOG" id="ENOG502SF08">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032510_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z194"/>
    <dbReference type="OMA" id="NDHLFYD"/>
    <dbReference type="OrthoDB" id="5278722at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU42531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="515" mass="58028" checksum="422D780D36E705EC" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1J0</accession>
    <name>C7Z1J0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycerophosphocholine acyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NECHADRAFT_64104</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
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        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU42013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003047680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1J0"/>
    <dbReference type="FunCoup" id="C7Z1J0">
        <property type="interactions" value="189"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z1J0"/>
    <dbReference type="GeneID" id="9671677"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_64104"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_64104"/>
    <dbReference type="eggNOG" id="KOG2895">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018994_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z1J0"/>
    <dbReference type="OMA" id="WKRRVPT"/>
    <dbReference type="OrthoDB" id="406287at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021261">
        <property type="entry name" value="GPCAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201">
        <property type="entry name" value="OS01G0585100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10998">
        <property type="entry name" value="DUF2838"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="470"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="553"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU42013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="571" mass="64711" checksum="526F24EA77C6BE13" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z2F3</accession>
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        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_105684</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047365.1">
        <property type="nucleotide sequence ID" value="XM_003047319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z2F3"/>
    <dbReference type="FunCoup" id="C7Z2F3">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="GeneID" id="9676355"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_105684"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_105684"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_11_5_1"/>
    <dbReference type="InParanoid" id="C7Z2F3"/>
    <dbReference type="OMA" id="SMIHETN"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000254">
        <property type="entry name" value="MAL31p Maltose permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF5">
        <property type="entry name" value="ALPHA-GLUCOSIDES PERMEASE MPH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="38"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU41652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="547" mass="60639" checksum="ECD32D6B5A2E0795" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z2K7</accession>
    <name>C7Z2K7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_105688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047395.1">
        <property type="nucleotide sequence ID" value="XM_003047349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z2K7"/>
    <dbReference type="STRING" id="660122.C7Z2K7"/>
    <dbReference type="GeneID" id="9676048"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_105688"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_105688"/>
    <dbReference type="eggNOG" id="KOG3851">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030742_2_2_1"/>
    <dbReference type="InParanoid" id="C7Z2K7"/>
    <dbReference type="OMA" id="ERYSMFI"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070224">
        <property type="term" value="F:sulfide:quinone oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070221">
        <property type="term" value="P:sulfide oxidation, using sulfide:quinone oxidoreductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000203">
        <property type="entry name" value="Related to sulfide:quinone oxidoreductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015904">
        <property type="entry name" value="Sulphide_quinone_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632:SF2">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="31"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU41682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="441" mass="48356" checksum="E97D08C54A4D282F" modified="2009-10-13" version="1">MLRSRVTLAARTAGRSFAPDAPVAPVSRDHKVVVIGAGSAGISISHQLLRTGKFGQDDIAVVDPAQWHHYQPGWTLVGAGLKDKEDLKSSLSELVDPKFKFYNVSVEGLAPEENSVKLANGKKISYDHLVVAPGIKINYDSIKGLPEALATRDSPVTSIYGYETCDKVFPAIQRLQKGNAIFTQPAGVIKCAGAPQKAMWLALDHWKQTDLYNPEDVSKSPIKISFATGLPTMFGVPKYSAALEKLRQERGVEGLFQHDLVAIEGNKAIFARPDGQENVTKQFDFLHVVPKMGPHAFVKNSALANEAGYVDVDDNTTRHKKFANVWSAGDASSLPTSKTAAAVTSEAPVLVGNLLRAMEGKEPEPLYDGYTSCPLPTEYGKLMLAEFKYGGVPKETFGDLFGIDQAVPRRSFYYMKKDFFPWVYQKYMVKGQWGGPKGWIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z2N6</accession>
    <name>C7Z2N6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_87662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047222.1">
        <property type="nucleotide sequence ID" value="XM_003047176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z2N6"/>
    <dbReference type="GeneID" id="9676398"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87662"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87662"/>
    <dbReference type="HOGENOM" id="CLU_060131_6_3_1"/>
    <dbReference type="InParanoid" id="C7Z2N6"/>
    <dbReference type="OMA" id="PCYRLSF"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="75"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU41509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="219" mass="24960" checksum="F9D76AD0E432ED3B" modified="2009-10-13" version="1">MVVINSPEPSEARRLGEIYVSSMAENPVVIVQFPTPERRQELQAYFTISIEHAIQKRPDRTLVARNDDGRILSFIHWDVIHPHTADEEVEELNTQPKPDPAAGDSVSFDSETLSWQSNYLAIAEDARVKSMGQRRYIHLVYVSTDPNHQGHGAASKLMSRLMEVAVSERLPIWLESTMNAVPFYEKKGWKRVCKICTPAPRNVGESHEDVYEEQVYDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z3D1</accession>
    <name>C7Z3D1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotransferase class V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_54138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047528.1">
        <property type="nucleotide sequence ID" value="XM_003047482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z3D1"/>
    <dbReference type="STRING" id="660122.C7Z3D1"/>
    <dbReference type="GeneID" id="9676035"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_54138"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_54138"/>
    <dbReference type="eggNOG" id="KOG1549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_2_1_1"/>
    <dbReference type="InParanoid" id="C7Z3D1"/>
    <dbReference type="OMA" id="YGWMALR"/>
    <dbReference type="OrthoDB" id="5978656at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586:SF8">
        <property type="entry name" value="CYSTEINE DESULFURASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="80"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU41815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="424" mass="46289" checksum="3DBB1D7F60E38AF6" modified="2009-10-13" version="1">MAPSLVDAVVDSSTPITFPKDGQPDAKWSAYRRLVPLVDADGYTYLNASFAPPSNLIVHDALTRYANDALHSPAPKPQWQNMAIETRELIATYINAPSPESVALTRDTTEGLNCFIRGMNFAPGDNVVILDSEHPNHAYAWMAMRASGLEVRQVPTVTIAEKTGIVSAANADTFAPYVDDRTRAIGISSVMFHSGQRNDIAAISARYRPKGIHVLVDMTQQVGFAAVDVQALGLSAAAFGLHKGLNCPTGLAALYVDPRVIAETDPHPPIVGYGAVHNTRADLLVPSDEITYHPNARRFEHLNVSLVATTAANAFLKFYLNEMGPENVEEHLFSLGDALRRECQDLGISIVGPTSRKEHAPHLYILDVHDPRWAEHLCENQILVTPYRLGIRVSFGFYNNLEDVKKLAVVLKSGLELGLPVGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z3F1</accession>
    <name>C7Z3F1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_88893</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698908">
        <property type="protein sequence ID" value="EEU41457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047170.1">
        <property type="nucleotide sequence ID" value="XM_003047124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z3F1"/>
    <dbReference type="GeneID" id="9675786"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88893"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88893"/>
    <dbReference type="eggNOG" id="ENOG502QYI1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_348535_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z3F1"/>
    <dbReference type="OrthoDB" id="5069391at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="364"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="550"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="380"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="564"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU41457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="809" mass="89780" checksum="284A60EA2C6DCD05" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z3L8</accession>
    <name>C7Z3L8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_104938</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046870.1">
        <property type="nucleotide sequence ID" value="XM_003046824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z3L8"/>
    <dbReference type="FunCoup" id="C7Z3L8">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="GeneID" id="9675457"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_104938"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_104938"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_11_5_1"/>
    <dbReference type="InParanoid" id="C7Z3L8"/>
    <dbReference type="OMA" id="YELTAAW"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000023">
        <property type="term" value="P:maltose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000149">
        <property type="entry name" value="MFS transporter, SP family, general alpha glucoside:H+ symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF5">
        <property type="entry name" value="ALPHA-GLUCOSIDES PERMEASE MPH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="379"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="31"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU41157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="523" mass="58848" checksum="ABA0621349B471A4" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z457</accession>
    <name>C7Z457_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_46233</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047134.1">
        <property type="nucleotide sequence ID" value="XM_003047088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z457"/>
    <dbReference type="GeneID" id="9675308"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_46233"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_46233"/>
    <dbReference type="eggNOG" id="ENOG502QPMY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044876_6_0_1"/>
    <dbReference type="InParanoid" id="C7Z457"/>
    <dbReference type="OMA" id="DYWMSWG"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU41421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="336" mass="36750" checksum="B7EC04FC4228DFE2" modified="2009-10-13" version="1">MKVAIVGASGETGGSIVKALLESSTPKFDITALTRPASLTKPENLELEKRGVKLVACKLDGPEDALVKSLSGQDVVISALEPAAFGAQIPLANAAKVAGVKRFVPCAFATIAPPGVMKLRDDKEDIFNHVKKLYLPYTIIDVGWWFQLAVPRLSSGKTDYAIVVPENTAAGDGNVPSAFTDIRDIGPYVARIISDPRTLNKMVFAYDEVATTNQIYELLEKLSGEKIDRTYVRHHSPLGQDMANQIHSSQLSADDIETGLAQIEGSDDPTALNKLWILQYLRSCGIRGDNNPEYARYLGYVDAKELYPDFKGNTLEKYFQEVLVGKAKGVYKKRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4M0</accession>
    <name>C7Z4M0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_122357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046659.1">
        <property type="nucleotide sequence ID" value="XM_003046613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4M0"/>
    <dbReference type="GeneID" id="9678191"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_122357"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_122357"/>
    <dbReference type="eggNOG" id="ENOG502SEZR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1571073_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z4M0"/>
    <dbReference type="OMA" id="NNDRCAP"/>
    <dbReference type="OrthoDB" id="5052446at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988821" evidence="1">
        <location>
            <begin position="20"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU40946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="170" mass="18978" checksum="E3C664AF20FA80BE" modified="2009-10-13" version="1">MKSTFTLAALSLFASQCLAASVDMWSAPLSARSAAKYEPIDPEVIKSRLGTTPEENDPEHRHPGMVYFCREENWGPPCFVYYPELEYTCSELGPELAGHVGSVFVEPGAICRMATAQDRCNPIEFFAWPETQNGWPDLFQRESPDGEGKLGYETTHFTCAECTNCVRNPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4Q3</accession>
    <name>C7Z4Q3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Vacuolar protein sorting-associated protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_58332</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the retromer complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the VPS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046675.1">
        <property type="nucleotide sequence ID" value="XM_003046629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4Q3"/>
    <dbReference type="FunCoup" id="C7Z4Q3">
        <property type="interactions" value="58"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z4Q3"/>
    <dbReference type="GeneID" id="9678480"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_58332"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_58332"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028982_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z4Q3"/>
    <dbReference type="OMA" id="FYLGTME"/>
    <dbReference type="OrthoDB" id="9976382at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030905">
        <property type="term" value="C:retromer, tubulation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06891">
        <property type="entry name" value="PX_Vps17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000046">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000034">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014461">
        <property type="entry name" value="Retromer_complex_Vps17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053055">
        <property type="entry name" value="VPS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037907">
        <property type="entry name" value="Vps17_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011791">
        <property type="entry name" value="Vps17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="8">
        <location>
            <begin position="166"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Sorting nexin/Vps5-like C-terminal" evidence="9">
        <location>
            <begin position="297"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="491"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="533"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR011791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU40962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="595" mass="65072" checksum="8C0AA8229060E76B" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z5J4</accession>
    <name>C7Z5J4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_76887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU41112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046825.1">
        <property type="nucleotide sequence ID" value="XM_003046779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z5J4"/>
    <dbReference type="GeneID" id="9678349"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76887"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76887"/>
    <dbReference type="eggNOG" id="ENOG502T6BF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2250787_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z5J4"/>
    <dbReference type="OMA" id="STHEIEY"/>
    <dbReference type="OrthoDB" id="5099784at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU41112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="104" mass="11622" checksum="1A4B0CDBB97607C3" modified="2009-10-13" version="1">MSDSSANSSPISSPIKTRRCSSTASSESSLRDLETEYLALRDEHLSYEDDAEFHIFIDALDRVDTLVTEHTPKAERRKSFGRILSGFKMHKNKDKTSGSAEEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z687</accession>
    <name>C7Z687_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_76016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046368.1">
        <property type="nucleotide sequence ID" value="XM_003046322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z687"/>
    <dbReference type="GeneID" id="9667928"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76016"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76016"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015676_3_1_1"/>
    <dbReference type="InParanoid" id="C7Z687"/>
    <dbReference type="OMA" id="SCIIHFH"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF68">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU40655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="598" mass="66390" checksum="320617EAC8B0A19E" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6F8</accession>
    <name>C7Z6F8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Homoaconitase, mitochondrial</fullName>
            <ecNumber evidence="5 17">4.2.1.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 17">Homoaconitate hydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">NECHADRAFT_103327</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 17">Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>(2R,3S)-homoisocitrate = cis-homoaconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15485"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15404"/>
            <dbReference type="ChEBI" id="CHEBI:58174"/>
            <dbReference type="EC" id="4.2.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="17">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 3/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.36" evidence="5 17"/>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045837.1">
        <property type="nucleotide sequence ID" value="XM_003045791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6F8"/>
    <dbReference type="FunCoup" id="C7Z6F8">
        <property type="interactions" value="143"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z6F8"/>
    <dbReference type="GeneID" id="9668671"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_103327"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_103327"/>
    <dbReference type="eggNOG" id="KOG0453">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006714_3_1_1"/>
    <dbReference type="InParanoid" id="C7Z6F8"/>
    <dbReference type="OMA" id="EGMAEVC"/>
    <dbReference type="OrthoDB" id="10262323at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER01027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004409">
        <property type="term" value="F:homoaconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01674">
        <property type="entry name" value="Homoaconitase_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000013">
        <property type="entry name" value="Homoaconitase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004418">
        <property type="entry name" value="Homoaconitase_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039386">
        <property type="entry name" value="Homoaconitase_swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00139">
        <property type="entry name" value="h_aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF2">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0408">Iron</keyword>
    <keyword evidence="11 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="13 17" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="19">
        <location>
            <begin position="28"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="20">
        <location>
            <begin position="512"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EEU40124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="692" mass="75028" checksum="3FF461B8BAC8339F" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6Q6</accession>
    <name>C7Z6Q6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_32832</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046447.1">
        <property type="nucleotide sequence ID" value="XM_003046401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6Q6"/>
    <dbReference type="GeneID" id="9668721"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_32832"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_32832"/>
    <dbReference type="eggNOG" id="ENOG502QSZ7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021993_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z6Q6"/>
    <dbReference type="OMA" id="AHGSYGV"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000308">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF6">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="25"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU40734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="415" mass="44530" checksum="E8B7E7B5D851FDBF" modified="2009-10-13" version="1">MSRPSSPEAVEVMPSAWQPFMNRFRLFAVCLANLGNALSDSAAGALIPYMEKYYNIGYGIVSLIFVGQAIGFIMAAVFLDALRAKLGRAKLLGLGQAMVTLSYIPLICGAPFPIIVCSFFFVGFSISVNVGIGNLFCGGLRNGTFMLGLLHGTYGIGGTVGPLIATALVTAANALWTRYYILTCAIGVCTFSLAMWSFWNYEKEMSPAVRARETAQAGESMMNSMFMAMKLRVVLLGSIFIFAYQGAEVSISGWVISFLINARDGDPSSVGYVTAGFWAGITLGRFFLSGPAHRIGEKPFVYGLTIGALAFQILVWFVPNIVGNAVAVSIVGLLLGPIYPCGAAVFMRRMNRREVLSGIGTISACGSAGGAVAPFITGLLAQAAGTFVLHPIVIFLFLVMLLCWYFLPDEEKRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z758</accession>
    <name>C7Z758_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_58084</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046528.1">
        <property type="nucleotide sequence ID" value="XM_003046482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z758"/>
    <dbReference type="FunCoup" id="C7Z758">
        <property type="interactions" value="964"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z758"/>
    <dbReference type="GeneID" id="9668867"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_58084"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_58084"/>
    <dbReference type="eggNOG" id="KOG0176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_4_2_1"/>
    <dbReference type="InParanoid" id="C7Z758"/>
    <dbReference type="OMA" id="RSMIDHA"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03753">
        <property type="entry name" value="proteasome_alpha_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000015">
        <property type="entry name" value="Proteasome subunit alpha type-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033812">
        <property type="entry name" value="Proteasome_alpha_type_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU40815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="245" mass="26942" checksum="231CB2376A4EB4B7" modified="2009-10-13" version="1">MFMARSEYDRGINTFSPEGRLFQVEYSLEAIKLGSTAIGVATSEGVILGVEKRVTSTLLETSSVEKIVEIDRHIGCAMSGLQADARSMVEHARVECQSHSFNYNEPLRVESCTQAICDLALRFGEGADGEETIMSRPFGVALLIAGFDEDGPQLFHAEPSGTFYRYDAKAIGSGSEGAQAELQNEYHKSLTLTDAETLVLKTLKQVMEEKLDAKNVQLASVTREKGFRIYTDEEMATVVERLPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z763</accession>
    <name>C7Z763_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Iron-sulfur cluster biogenesis chaperone, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_66327</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria. Assisted by the DnaJ-like co-chaperone jac1 and the nucleotide exchange factor mge1, it mediates ATP-dependent Fe-S cluster transfer from the scaffold proteins isu1/isu2 to grx5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046530.1">
        <property type="nucleotide sequence ID" value="XM_003046484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z763"/>
    <dbReference type="FunCoup" id="C7Z763">
        <property type="interactions" value="1537"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z763"/>
    <dbReference type="GeneID" id="9668870"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_66327"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_66327"/>
    <dbReference type="eggNOG" id="KOG0102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_2_1_1"/>
    <dbReference type="InParanoid" id="C7Z763"/>
    <dbReference type="OMA" id="MGTDWKI"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11734">
        <property type="entry name" value="ASKHA_NBD_HSP70_Ssc1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000020">
        <property type="entry name" value="Chaperone protein HscA homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000003">
        <property type="entry name" value="Heat shock protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000007">
        <property type="entry name" value="Heat shock protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003520">
        <property type="entry name" value="PRK05183.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="645"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="575"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="646"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="656"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="668"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU40817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="677" mass="73267" checksum="C86E1447ACFFEDFA" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7K6</accession>
    <name>C7Z7K6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar membrane-associated protein IML1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Vacuolar membrane-associated protein iml1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_33271</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IML1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046030.1">
        <property type="nucleotide sequence ID" value="XM_003045984.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="C7Z7K6">
        <property type="interactions" value="628"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z7K6"/>
    <dbReference type="GeneID" id="9668389"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_33271"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_33271"/>
    <dbReference type="eggNOG" id="KOG3572">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000935_1_1_1"/>
    <dbReference type="InParanoid" id="C7Z7K6"/>
    <dbReference type="OMA" id="SWMNATP"/>
    <dbReference type="OrthoDB" id="39497at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04449">
        <property type="entry name" value="DEP_DEPDC5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045838">
        <property type="entry name" value="DEPDC5_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048255">
        <property type="entry name" value="IML1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19418">
        <property type="entry name" value="DEPDC5_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12257">
        <property type="entry name" value="IML1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="6">
        <location>
            <begin position="1325"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="506"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="773"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="826"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1431"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="784"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="826"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="851"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1461"/>
            <end position="1474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU40317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1841" mass="207258" checksum="CB711318C292B3C9" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8W0</accession>
    <name>C7Z8W0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SH3b domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_94402</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.17"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044754.1">
        <property type="nucleotide sequence ID" value="XM_003044708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8W0"/>
    <dbReference type="GeneID" id="9673664"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94402"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94402"/>
    <dbReference type="eggNOG" id="ENOG502S6UW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091454_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z8W0"/>
    <dbReference type="OMA" id="FHRVPKA"/>
    <dbReference type="OrthoDB" id="5358886at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00737">
        <property type="entry name" value="lyz_endolysin_autolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04110">
        <property type="entry name" value="ENDOLYSIN_T4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051018">
        <property type="entry name" value="Bacteriophage_GH24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033907">
        <property type="entry name" value="Endolysin_autolysin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034690">
        <property type="entry name" value="Endolysin_T4_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002196">
        <property type="entry name" value="Glyco_hydro_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023347">
        <property type="entry name" value="Lysozyme_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38107">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38107:SF3">
        <property type="entry name" value="LYSOZYME RRRD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00959">
        <property type="entry name" value="Phage_lysozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51781">
        <property type="entry name" value="SH3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="3" id="KW-0081">Bacteriolytic enzyme</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002989035" description="SH3b domain-containing protein" evidence="7">
        <location>
            <begin position="19"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="8">
        <location>
            <begin position="16"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU39041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="262" mass="27905" checksum="C710CB2F105325D4" modified="2009-10-13" version="1">MKLSLFTISALAASLASAYPITGDDVRCRSGPGTSYAIKKTFKKGTNVKITCQTTGTNIKGNNIWDKVSEGCYVSDYYVKTGSSGFVTKKCPGSGGSCGAPKSNQATVNLIASFEGFRANIYKDAAGYPTVGYGHLCSNSKCTDVKYSIPLSQANGKKLLASDMAKFEKCITAMVKSNVKLNKNQYGALVSWSFNNGCGAAKTSTLIKRLNKGEAPNTVISQELPKWVYAGGKKLNGLVRRRKAEVALAKKATTEKALPKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8W2</accession>
    <name>C7Z8W2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_70193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045168.1">
        <property type="nucleotide sequence ID" value="XM_003045122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8W2"/>
    <dbReference type="GeneID" id="9673666"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_70193"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_70193"/>
    <dbReference type="eggNOG" id="ENOG502S4CM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090700_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z8W2"/>
    <dbReference type="OMA" id="HYESMTC"/>
    <dbReference type="OrthoDB" id="3354680at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU39455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="233" mass="25988" checksum="1079FAE408F42405" modified="2009-10-13" version="1">MALRTVSGKILATSLVAAVTVGGTYGFMVQRRVRLVDRGQITRFETIPESFEKSRSVSEIVNAGNHARVSDSRFIALDIPSQHHDVSDEVLLAKFVKGYFGGAVIGPERRTLQTLGRNLLPSINTVLFGVFQTLDSHLAKEQVKDGVDRTESYVDFGFGSDKFWFGGVHRFAVVRSRNEEGEETVQVHCQSMSCNPSVNKPLRPSWMFAFHKAYADLLFRDGVSEIKRWMGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z919</accession>
    <name>C7Z919_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endo-chitosanase</fullName>
            <ecNumber evidence="10">3.2.1.132</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_94265</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Chitosanase catalyzing the endo-type cleavage of chitosan, the deacylated form of chitin. Chitosanase may be crucial in the degradation of the deacetylated portion of chitin in the fungal cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endohydrolysis of beta-(1-&gt;4)-linkages between D-glucosamine residues in a partly acetylated chitosan.</text>
            <dbReference type="EC" id="3.2.1.132"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 75 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.132" evidence="10"/>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045054.1">
        <property type="nucleotide sequence ID" value="XM_003045008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z919"/>
    <dbReference type="GeneID" id="9673494"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94265"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94265"/>
    <dbReference type="eggNOG" id="ENOG502S39Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046555_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z919"/>
    <dbReference type="OMA" id="DCDGVQG"/>
    <dbReference type="OrthoDB" id="4756206at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016977">
        <property type="term" value="F:chitosanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009939">
        <property type="entry name" value="Chitosanase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42061">
        <property type="entry name" value="ENDO-CHITOSANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42061:SF6">
        <property type="entry name" value="ENDO-CHITOSANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07335">
        <property type="entry name" value="Glyco_hydro_75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005125801" description="Endo-chitosanase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU39341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="300" mass="31626" checksum="E2138EAB0020EDA5" modified="2009-10-13" version="1">MPSLRNTLLASLLAASVSARDVPANVKSFKDSIIKQGSCKSTLATGFYSSDGDSGTYSYCGDHVKDYNVIYLQGKNGKLVNMDIDCDGIQGSPADDGRCGSSGDTQSITSFQWVLESYGTSQKDLDANIHPYIVFGNEGTKSGWKTFDPEKHGIKPLSVMAVVCGNKMFYGIWGDENGDDGDYPMVGEASISLATACFGKSMNGNFGHGEDDVLYIAFPGSDAVPGAKGAKWTAKNFDEFQSSITTLGDKLIKRIGSSSGGGTTPPPTCSWPGHCQGATCKTGDDCSDDLICTNGKCSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z943</accession>
    <name>C7Z943_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_43145</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045069.1">
        <property type="nucleotide sequence ID" value="XM_003045023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z943"/>
    <dbReference type="STRING" id="660122.C7Z943"/>
    <dbReference type="GeneID" id="9673080"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_43145"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_43145"/>
    <dbReference type="eggNOG" id="KOG0406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_9_1_1"/>
    <dbReference type="InParanoid" id="C7Z943"/>
    <dbReference type="OMA" id="PEGPWFL"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045174">
        <property type="term" value="F:glutathione dehydrogenase (ascorbate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005442">
        <property type="entry name" value="GST_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF13">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE OMEGA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01625">
        <property type="entry name" value="GSTRNSFRASEO"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="27"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="122"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU39356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="31907" checksum="D571BE8A44E5C45F" modified="2009-10-13" version="1">MTNVDTSLPAEPSGAAAEFAARHSEEHPLKLYGGWFCPFVQRSWITLHEKNVPHQYIEINPYKKEASFLAMNPRGLVPTLAVPVGTKGEVQKPLFESNIVCEYLDEAYADEATYGPRLLPSDPYERARCRLWIDHISSRIIPAFYKLLQHTPEKPYSLDQAREELHGHIKTLVKEMDAKGPWFLGDNLSLVDICLAPWVKRLFLIDHYKNGGHGIPQSGGGDDEGTWARWRKWSDAILDRKSVKETWSADERYIIAYKRYADDTTNSLVGQATREGKRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9E6</accession>
    <name>C7Z9E6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_94456</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044794.1">
        <property type="nucleotide sequence ID" value="XM_003044748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9E6"/>
    <dbReference type="GeneID" id="9673368"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94456"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94456"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_13_2_1"/>
    <dbReference type="InParanoid" id="C7Z9E6"/>
    <dbReference type="OMA" id="QGNLLWV"/>
    <dbReference type="OrthoDB" id="5296at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU39081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="299" mass="32984" checksum="A84C8743B84D286E" modified="2009-10-13" version="1">MSAYTVKDRFAIVTGGGSAGCSVIIADLRLRPEAEPLVSEYPHPAKESNKPSLVFCETDISDWTQITALWKTALETFGRIDIVVNSAGVYEPPSSSFWKPPGISPLSEDPEDAKVGQYKSFAINTIGPIRLSQIAIDYWQQNPEVEGNLLWVASMGGYMHSMQAPLYFASKAALVSMVKSLSGLRRALNIRNSAVCPGPCFTPIFEQEYCRDRLRPGDIALKPEDCAELIMRVLQEPQYGDGNIVEIMMIGTKEEQTVNVREIGLEALYPTVGPLDQGTRAMAEELKFFGEVKEKGMHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9R4</accession>
    <name>C7Z9R4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_44201</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Gln) + L-glutamine + ATP = L-glutaminyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="2"/>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045261.1">
        <property type="nucleotide sequence ID" value="XM_003045215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9R4"/>
    <dbReference type="FunCoup" id="C7Z9R4">
        <property type="interactions" value="1317"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z9R4"/>
    <dbReference type="GeneID" id="9672216"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_44201"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_44201"/>
    <dbReference type="eggNOG" id="KOG1148">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001882_2_3_1"/>
    <dbReference type="InParanoid" id="C7Z9R4"/>
    <dbReference type="OMA" id="TWCIYPM"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000007">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000015">
        <property type="entry name" value="Glutaminyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000183">
        <property type="entry name" value="Glutaminyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF4">
        <property type="entry name" value="GLUTAMINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="11">
        <location>
            <begin position="93"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="12">
        <location>
            <begin position="413"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="13">
        <location>
            <begin position="520"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="23"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU39548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="633" mass="72000" checksum="D45A550A685149DE" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZA84</accession>
    <name>C7ZA84_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_104861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044943.1">
        <property type="nucleotide sequence ID" value="XM_003044897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZA84"/>
    <dbReference type="STRING" id="660122.C7ZA84"/>
    <dbReference type="GeneID" id="9672125"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_104861"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_104861"/>
    <dbReference type="eggNOG" id="ENOG502S9QS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008442_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZA84"/>
    <dbReference type="OMA" id="CAFLAYN"/>
    <dbReference type="OrthoDB" id="4088568at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="400"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="501"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="604"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="56"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="253"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="352"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="400"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="607"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="693"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU39230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="705" mass="78461" checksum="8553B119AE5EA212" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAQ0</accession>
    <name>C7ZAQ0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_98227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698913">
        <property type="protein sequence ID" value="EEU38897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044610.1">
        <property type="nucleotide sequence ID" value="XM_003044564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAQ0"/>
    <dbReference type="STRING" id="660122.C7ZAQ0"/>
    <dbReference type="GeneID" id="9672917"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_98227"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98227"/>
    <dbReference type="eggNOG" id="KOG4626">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001305_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZAQ0"/>
    <dbReference type="OMA" id="PFANKEV"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19959:SF119">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19959">
        <property type="entry name" value="KINESIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="1">
        <location>
            <begin position="630"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="949" mass="104950" checksum="34BD6BA32411FD55" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAQ9</accession>
    <name>C7ZAQ9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_98229</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698913">
        <property type="protein sequence ID" value="EEU38888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044601.1">
        <property type="nucleotide sequence ID" value="XM_003044555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAQ9"/>
    <dbReference type="FunCoup" id="C7ZAQ9">
        <property type="interactions" value="266"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZAQ9"/>
    <dbReference type="GeneID" id="9672921"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_98229"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98229"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="InParanoid" id="C7ZAQ9"/>
    <dbReference type="OMA" id="AWYAMSK"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000191">
        <property type="entry name" value="Methylglyoxal reductase (NADPH-dependent)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU38888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="338" mass="37204" checksum="CD1DC45145272684" modified="2009-10-13" version="1">MSKVLLTGGSGFVAAHVVKTLLERGHTVVTTVRSKTKGDQILAAHSGNQLKRLSYVIVSDIASRGAFDKAVQSEPPFDYVIHTASPFHDNWQDPVKDVLNPAIDGTTGILKAIQKYAPQVKRVVLTSSFAAIVNTASPPKVYDESSWNPITWNEAIAERSLVYRGSKKLAEEAAWKFMEDETPIFDLVTMNPPLVYGPIAHHLENLGSLNTSNTRIRDFVQGKVTTNELPPTGTYLFVDVRDLALAHVRAIEVPEAGGKRFFMVGGHCSHKRIVDAIRETHPGLASKLPKDPIDDFPADVYGYDNSRAREVLGIQFRSLWECIGDTAASLMKAIEQDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZB55</accession>
    <name>C7ZB55_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_45843</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044461.1">
        <property type="nucleotide sequence ID" value="XM_003044415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZB55"/>
    <dbReference type="GeneID" id="9672764"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45843"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45843"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006937_6_1_1"/>
    <dbReference type="InParanoid" id="C7ZB55"/>
    <dbReference type="OMA" id="YQATFES"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF7">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU38748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="57432" checksum="4DABB2017206CEFE" modified="2009-10-13" version="1">MSFHNPLKDQAIDQPRPIKVICIGAGFSGILTAIRFPQRISNLELTIYEKNDDIGGTWYENTCVSHVPSHVYQYSFAGNPNWSKFYAGGAEIQQYLKDVAWRYNVEKYVRLQHHFEKADWDETTQKWTVTVKDLRNNTTLTDTADILIKGTGILNKWKWPEIKGLQSFKGSLMHTAGWDPKFDWADKRVALIGAGSSGIQVLPHIQSKAKHIFHYMRGKTWISPVGYAAEVGGGANRDYTAAERMDFANNPQTYMEYRHMVEGVMNKGQLSTFLGSDVQKQFWEESDAFMRRKLEKKPEIYKSLIPNFPPGCRRLTPGPGYLEALVEDNVAFIGAGIKEVTENGLFDTNGGFHEVDVIICATGFDYSWSTEDTPITGRSGITLGKMWDPCPEAYMGVTVPNIPNFFMYLGPAGAPGSGSFITMLEFVVEYIIKCVKKLQREYISSLEPTSMDAHVDFCKQADKLFEQCKSWFKRNSETGRIVGIWPGSSVHAQQAMENPRFEDFRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZB65</accession>
    <name>C7ZB65_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gylcosyl hydrolase 115 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_95198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044594.1">
        <property type="nucleotide sequence ID" value="XM_003044548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZB65"/>
    <dbReference type="GeneID" id="9670788"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95198"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95198"/>
    <dbReference type="eggNOG" id="ENOG502SHTR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004852_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZB65"/>
    <dbReference type="OMA" id="GKVWHQL"/>
    <dbReference type="OrthoDB" id="4849794at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.520">
        <property type="entry name" value="Glycosyl hydrolase family 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031924">
        <property type="entry name" value="GH115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041437">
        <property type="entry name" value="GH115_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042301">
        <property type="entry name" value="GH115_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37842">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37842:SF2">
        <property type="entry name" value="GYLCOSYL HYDROLASE 115 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17829">
        <property type="entry name" value="GH115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15979">
        <property type="entry name" value="Glyco_hydro_115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gylcosyl hydrolase 115 C-terminal" evidence="2">
        <location>
            <begin position="792"/>
            <end position="965"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU38881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="976" mass="110430" checksum="07F4EE9BF0A1D692" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBM2</accession>
    <name>C7ZBM2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_88522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698915">
        <property type="protein sequence ID" value="EEU38619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044332.1">
        <property type="nucleotide sequence ID" value="XM_003044286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBM2"/>
    <dbReference type="GeneID" id="9670655"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88522"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88522"/>
    <dbReference type="HOGENOM" id="CLU_1482375_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZBM2"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="182" mass="19912" checksum="E4546376F83F959D" modified="2009-10-13" version="1">MHGEESSHSGPPPPKTKELAAEKLTGYGIPSPHRHGTTSEYDSSANNFVFDKSGVLHARRRRIRLRQAQPPRIVKASSSQCPPANTKFCPCGCIRNRQSSTPPGTISYPPHRPQRKLLQGCVLCMQQYPVPEELMSSSTSRPFQSPSLTLPHRQRADSGGGKTSTLARSSIVMATQHATQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZC46</accession>
    <name>C7ZC46_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_66882</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="GG698918">
        <property type="protein sequence ID" value="EEU38305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044018.1">
        <property type="nucleotide sequence ID" value="XM_003043972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZC46"/>
    <dbReference type="STRING" id="660122.C7ZC46"/>
    <dbReference type="GeneID" id="9670264"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_66882"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_66882"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZC46"/>
    <dbReference type="OMA" id="CREGIRM"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009725">
        <property type="entry name" value="PRK13252.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU38305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="509" mass="54298" checksum="4E2B4D81DE2DF267" modified="2009-10-13" version="1">MTLSTEIHTFHSGRPQPESSSRSNTFTSVDPSTSKPLATIYTTTPSQLEDTIAAAHAAFPVWSQTPAPRRAAILLKAAAILRERNDELALTETLDTGKAWSETSTVDVVTGADVLEYYAHMAAGSFPGQNTRLRADAFVLTTHEPLGVCAGIGAWNYPIQIALWKSAPCLAAGNCMVYKPSEVTPLHANKLAQIYIEAGVPPGVFNVVYGDGPAVGAPLVAHSGIAKVSFTGQVSTGSKVAGQAAGDMKGITMELGGKSPLVILPDADVDEAADTAMVANFFSTGQVCTNGTRVFVPDTLLSRVEEALIQRAREGIRMGLPRDKKTNFGPMVSAAQQEKVKMYIEHGRSVDKAKLLYDGSTDAQSVLPTADGFWVPPVIFTNCTDEMRVVREEIFGPVMCILPYKTQGRAREDWLPELVSRANDTPMGLAAGVVSSDVGLAQEVIQKLDAGITWINTWGESPAEMPVGGWKMSGIGLENGHEGIQAYMRTKSTLVQLGKGACKGVFSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDK6</accession>
    <name>C7ZDK6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_88316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043671.1">
        <property type="nucleotide sequence ID" value="XM_003043625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZDK6"/>
    <dbReference type="GeneID" id="9669872"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88316"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88316"/>
    <dbReference type="eggNOG" id="ENOG502SMAU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054243_1_1_1"/>
    <dbReference type="InParanoid" id="C7ZDK6"/>
    <dbReference type="OMA" id="RYTHPSF"/>
    <dbReference type="OrthoDB" id="5275938at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="47205" checksum="5A516BB48EB758AB" modified="2009-10-13" version="1">MYAPVRRQGGRIDSCGSRRLFRRLAQVKSQLRPTPTLVEHNLRFDAYEKEMEKNIVDSDGDLALVSPYDPQTDAPSKNVSEKEDQPKSDDEKETIAQLEDREILVSSKILSNASPVFQAMLDGRFLEGVQLSDSKASPGQGPYRLLLPDDDFTAMLLLCRILHFKFKGIPEQPRSNLLLALAGVCDKYQCTQTLKYCGALWLRNWTSSLPDTEEASIENISRLLIFAYVADLPHEFCEVAWTLVLYHEGPIAGPHTQAIQLIDHPLLPNDIGRYLDLKRLQFCEAYHRAITAPWTTWQWTSLTSGCYRASHAISEYTLTLRGAGIVPYELDLRDHKLSDLLKAATNLPLLAVRSCTSRYNCGCSGDRTDSLTRDLRALARNIPKHKTWFGCLDCFKSGDTSNKDGKCRIEHGEITNLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZF06</accession>
    <name>C7ZF06_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_51427</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043237.1">
        <property type="nucleotide sequence ID" value="XM_003043191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZF06"/>
    <dbReference type="GeneID" id="9665352"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51427"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51427"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_10_1"/>
    <dbReference type="InParanoid" id="C7ZF06"/>
    <dbReference type="OMA" id="AMMELRM"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF78">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="502"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU37524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="559" mass="62718" checksum="4994CEA303BE23C5" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZF27</accession>
    <name>C7ZF27_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_86368</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043109.1">
        <property type="nucleotide sequence ID" value="XM_003043063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZF27"/>
    <dbReference type="GeneID" id="9665214"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86368"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86368"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="InParanoid" id="C7ZF27"/>
    <dbReference type="OMA" id="AEWPQNW"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF63">
        <property type="entry name" value="HIGH AFFINITY CYSTEINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU37396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="59010" checksum="14A09F0102D3D027" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFS1</accession>
    <name>C7ZFS1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_86655</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="GG698924">
        <property type="protein sequence ID" value="EEU36994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042707.1">
        <property type="nucleotide sequence ID" value="XM_003042661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFS1"/>
    <dbReference type="STRING" id="660122.C7ZFS1"/>
    <dbReference type="GeneID" id="9664916"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86655"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86655"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_4_0_1"/>
    <dbReference type="InParanoid" id="C7ZFS1"/>
    <dbReference type="OMA" id="HENHIEV"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF3">
        <property type="entry name" value="BETA-GLUCOSIDASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="10">
        <location>
            <begin position="286"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU36994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="720" mass="77878" checksum="DAB976F054CDD522" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFY8</accession>
    <name>C7ZFY8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_52219</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698924">
        <property type="protein sequence ID" value="EEU37140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042853.1">
        <property type="nucleotide sequence ID" value="XM_003042807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFY8"/>
    <dbReference type="GeneID" id="9664890"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_52219"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_52219"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="C7ZFY8"/>
    <dbReference type="OMA" id="IWINVIL"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF38">
        <property type="entry name" value="PROLINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="55"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU37140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="551" mass="60472" checksum="6EBB06745E333773" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZGE1</accession>
    <name>C7ZGE1_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_42353</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EEU36919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003042586.1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_42353"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_31_1_1"/>
    <dbReference type="InParanoid" id="C7ZGE1"/>
    <dbReference type="OMA" id="KMRGGEF"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Polyketide synthase Pks12"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
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    </dbReference>
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        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
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    </dbReference>
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        <property type="entry name" value="Ac_transferase_dom_sf"/>
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        <property type="entry name" value="ACP-like_sf"/>
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        <property type="entry name" value="Acyl_transferase_dom"/>
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        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
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        <property type="entry name" value="GroES-like_sf"/>
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    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
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    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
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        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
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    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
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    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
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    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
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        <property type="entry name" value="PKS_dehydratase_sf"/>
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    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
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    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
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        <property type="entry name" value="PKS_DH_N"/>
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    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
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    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
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        <property type="entry name" value="PKS_PP-bd"/>
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        <property type="entry name" value="PP-bd_ACP"/>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
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        <property type="entry name" value="Thiolase-like"/>
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    </dbReference>
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        <property type="entry name" value="ketoacyl-synt"/>
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        <property type="entry name" value="PKS_KS"/>
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    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="94"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="976"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2430"/>
            <end position="2507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="976"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1115"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="9"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="1008"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU36919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="2515" mass="273295" checksum="ED01E308C02455A5" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZH31</accession>
    <name>C7ZH31_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_97249</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698927">
        <property type="protein sequence ID" value="EEU36740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042453.1">
        <property type="nucleotide sequence ID" value="XM_003042407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZH31"/>
    <dbReference type="GeneID" id="9669529"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_97249"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_97249"/>
    <dbReference type="eggNOG" id="ENOG502SHHF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_12_5_1"/>
    <dbReference type="InParanoid" id="C7ZH31"/>
    <dbReference type="OMA" id="QGGCATN"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF124">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="43"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="301"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="352"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU36740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="382" mass="42243" checksum="C65A17D51A4E196F" modified="2009-10-13" version="1">MSDTVYMMPPPEGEDRWAAGSMAPAQVVIGAVLFAFGSVIYGLRIYTRVGIMNNALRLDDYLTGAALFSCWMFYACTMGMVAQGGCAVNFWQVSQAKYQILLKWTIPVNIFYMLSSDLAKISLLFFYLRLCPERTFRRIVQVLAGLFVTYAVVYAMISLFGCQPIKASWDLVAMATGKCVDKFGFFLAASVANVVMDLVILLLPLRIVIPLQIPRRQKLSLLLLFTTGGFVIIVAIYNCVLTIKLFSSPNYTWGLAYELCWMYAELTGCIICASASSLKPFFKKCLPGIFSSLGASYGGPSHNTTKGSHVIRSRRQLSRRQSNAIELESGDDSESGRKIGDDDEAKLWPRPTAEDGGHTVQEDAAKGINIVSTTEIQYSSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZH41</accession>
    <name>C7ZH41_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_86432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698927">
        <property type="protein sequence ID" value="EEU36575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042288.1">
        <property type="nucleotide sequence ID" value="XM_003042242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZH41"/>
    <dbReference type="GeneID" id="9669403"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86432"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86432"/>
    <dbReference type="eggNOG" id="ENOG502RSI9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1185291_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZH41"/>
    <dbReference type="OMA" id="YHKPPKD"/>
    <dbReference type="OrthoDB" id="5106529at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002989150" evidence="2">
        <location>
            <begin position="18"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU36575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="234" mass="26207" checksum="57D478167DEA6E05" modified="2009-10-13" version="1">MKLSALTLLAITTGILAAPVADPVAVASYGYEAPKSSYGNKEVHYGNKDEKKYAHVKKPEHHNYKAPEKKPEYKAPVKKPSYKAPEKKPVYKAPAKKPAYKAPEKKPEYKAPVKKPAYKAPEKKPEYKAPAKKPAYKAPEKKPEYKAPVKKPAYKAPEKKPVYKAPAKKPAHNTYKAPEKKPEHNTYKAPAKKPAHNTYKAPAKKPAYKAPAKKPEHNTYKAPEKKPEHTSYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZH83</accession>
    <name>C7ZH83_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_28891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698927">
        <property type="protein sequence ID" value="EEU36707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042420.1">
        <property type="nucleotide sequence ID" value="XM_003042374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZH83"/>
    <dbReference type="GeneID" id="9669499"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_28891"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_28891"/>
    <dbReference type="eggNOG" id="ENOG502T5A1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092154_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZH83"/>
    <dbReference type="OMA" id="KWKLWAS"/>
    <dbReference type="OrthoDB" id="5075004at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU36707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="210" mass="23441" checksum="1A5202DC4720A883" modified="2009-10-13" version="1" fragment="single">KPSWLIHVEDRIAEENEQFDFRAIYFEIVRDLLLEPDNDGTAVPKAIKRFNEHYVAGFAGEDFGRRQPPEYAAGDILNEISIAVFETVGKVSFTDIRHDRLANLLTGIKRDTADEFNKEDPQFVFFGWGLEAAVAEDWNSSHAQGTTTDNEFRTATQASDSWVNKSALLAKLFSAGLLDADGTRWISGDFESAFKTRTSGDLATNIGKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHA2</accession>
    <name>C7ZHA2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_51936</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698927">
        <property type="protein sequence ID" value="EEU36716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042429.1">
        <property type="nucleotide sequence ID" value="XM_003042383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHA2"/>
    <dbReference type="STRING" id="660122.C7ZHA2"/>
    <dbReference type="GeneID" id="9669509"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51936"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51936"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_6_3_1"/>
    <dbReference type="InParanoid" id="C7ZHA2"/>
    <dbReference type="OMA" id="WHRPNAI"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="43"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU36716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="282" mass="31032" checksum="BD515C25A765542F" modified="2009-10-13" version="1" fragment="single">LDTGLEVTDFDIPTTDGIKIPIRLYRPIQGDSGSYHETQALYISLHGGGYHFGSLETEDPHCRQIALNIGCSVLNVNYRHTPDWTFPAPVDDSWAAFQWAAQKGPEYGIDPEKIFVGGVSAGANLAISVALRALRDDSLPSVKGLVLGTPSTVHPDHFPVELLKGGQSSLELHKDAPFINAQKLRNLIDLYRPDPSHPSFSPLLRPMSDFVALCPVSFHIAGLDPLRDEGLLMEEKMQTAGVQTTLHIYPGVPHAFMSLPTLPSAKRWRQGMHNDLKTWLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHE5</accession>
    <name>C7ZHE5_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_81155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698928">
        <property type="protein sequence ID" value="EEU36503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042216.1">
        <property type="nucleotide sequence ID" value="XM_003042170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHE5"/>
    <dbReference type="STRING" id="660122.C7ZHE5"/>
    <dbReference type="GeneID" id="9669097"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_81155"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_81155"/>
    <dbReference type="eggNOG" id="ENOG502SWNS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035152_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZHE5"/>
    <dbReference type="OMA" id="CMNESGF"/>
    <dbReference type="OrthoDB" id="5078134at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988111" evidence="1">
        <location>
            <begin position="21"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU36503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="560" mass="62011" checksum="48522812B1AD2D3D" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZIE6</accession>
    <name>C7ZIE6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_97506</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698930">
        <property type="protein sequence ID" value="EEU36190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041903.1">
        <property type="nucleotide sequence ID" value="XM_003041857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZIE6"/>
    <dbReference type="STRING" id="660122.C7ZIE6"/>
    <dbReference type="GeneID" id="9674284"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_97506"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_97506"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_12_1_1"/>
    <dbReference type="InParanoid" id="C7ZIE6"/>
    <dbReference type="OMA" id="DYLWNWD"/>
    <dbReference type="OrthoDB" id="2962696at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF18">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G12480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU36190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="285" mass="30161" checksum="163AAF8F05038441" modified="2009-10-13" version="1">MASAFEINNLFNVNGLIAVVTGGGSGIGLMIAQALEANGAIVYVIGRRKEVLESAVSTAKHGNIHPIQGDITNKKDLERAVSEIESSHGYVNAVIANAGIGGPSLNKLPSNPSISEFRNYVWGWDTKDLSTTFTINTVGVLNTVFAFLELLDAGNKKGNLKQRSQVIATSSIGGFNRSPALGYAYGGSKAAVTHIFKQLSTSLGQFNIRANVIAPGFYPSEMTTEAIEYRKTVGWPKSVVPEERPGDEEDIAGAILFLVSRAGAYINGNVLVTDGGRLGVVPASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJB1</accession>
    <name>C7ZJB1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_35094</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698933">
        <property type="protein sequence ID" value="EEU35821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041534.1">
        <property type="nucleotide sequence ID" value="XM_003041488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJB1"/>
    <dbReference type="FunCoup" id="C7ZJB1">
        <property type="interactions" value="1006"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZJB1"/>
    <dbReference type="GeneID" id="9673885"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_35094"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_35094"/>
    <dbReference type="eggNOG" id="KOG3103">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074741_3_0_1"/>
    <dbReference type="InParanoid" id="C7ZJB1"/>
    <dbReference type="OMA" id="PFQANYG"/>
    <dbReference type="OrthoDB" id="440385at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="8">
        <location>
            <begin position="122"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU35821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="319" mass="33181" checksum="0CCDE2669FB8225B" modified="2009-10-13" version="1">MSNYYSNQQPQYPGAGPSAAQNLQFFPSQYGPATGGTGTPQPGGAYGYGNQQAGFAGTPGAQGFSGAGYGAQGVSGRLGEQGGLRTGWVAAFSSEGYDGEPPLLEELGVNFGHIQAKTLAVLNPFRRIDSHLMDDSDLAGPLIFFLLFGFILLFSGKVHFGYIYGLAALGSVSLHLILSLMSPSDAGQQPQQPSYPQYSSEPSAPAPPPGQQGGHFSATLTYPRSASVLGYCLLPLVATSLFGIVMPMDTPIGIVFTTAAIMWCTYSASGMFCVVGRMKGMRGLVAYPLGLFYVGFGIMGIFSSRGSGSLSNAAAKLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJG7</accession>
    <name>C7ZJG7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_77250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698933">
        <property type="protein sequence ID" value="EEU35846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041559.1">
        <property type="nucleotide sequence ID" value="XM_003041513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJG7"/>
    <dbReference type="STRING" id="660122.C7ZJG7"/>
    <dbReference type="GeneID" id="9673987"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77250"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77250"/>
    <dbReference type="eggNOG" id="ENOG502QRBH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025711_4_3_1"/>
    <dbReference type="InParanoid" id="C7ZJG7"/>
    <dbReference type="OMA" id="EHDKFSV"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="10"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU35846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="237" mass="25910" checksum="BFB72193610D3870" modified="2009-10-13" version="1">MPGSKVLVLGGTGPAGICLLRELIHRNHEVVAFARNPKKIPEDLSSSPLIEIIEGELDNTEALSTAVSKSYVVVSLLGPMISSWKQDPSLLAGFYKDSLFPSMRQHGVKRVYAMGTISIVRPEDSRSLLRYGIKTLVRLAAGGAYRTIINISQTFEEDAKGLDWTIFRIAGIPGESDHESWKRDREDGKAFVGWVAETGWTMSQKRGALARWLVNAVEGGLTDWIGKMPAVSKLAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZL15</accession>
    <name>C7ZL15_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_78290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698942">
        <property type="protein sequence ID" value="EEU35297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041010.1">
        <property type="nucleotide sequence ID" value="XM_003040964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZL15"/>
    <dbReference type="GeneID" id="9675519"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78290"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78290"/>
    <dbReference type="HOGENOM" id="CLU_2062087_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZL15"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="119" mass="13147" checksum="380A6871979CADD2" modified="2009-10-13" version="1">MGVPLGLRVLGPWTWVRSVQGPLEVDKKGIRGLGLKGRQPSGGRRIRSRDEEKLRYNNIFKVNSSKVEVKQIRVGHVAKRIKDVERGIMTERSRLSHGPPGIPSVGTGCIQDHGGRTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZL95</accession>
    <name>C7ZL95_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_53281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698944">
        <property type="protein sequence ID" value="EEU35193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040906.1">
        <property type="nucleotide sequence ID" value="XM_003040860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZL95"/>
    <dbReference type="GeneID" id="9679296"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_53281"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_53281"/>
    <dbReference type="eggNOG" id="ENOG502SS3X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004184_7_2_1"/>
    <dbReference type="InParanoid" id="C7ZL95"/>
    <dbReference type="OMA" id="LLKRPWW"/>
    <dbReference type="OrthoDB" id="5416609at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="46"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="676" mass="77132" checksum="996AFB7809E788D3" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLC3</accession>
    <name>C7ZLC3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_53347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698944">
        <property type="protein sequence ID" value="EEU35214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040927.1">
        <property type="nucleotide sequence ID" value="XM_003040881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLC3"/>
    <dbReference type="GeneID" id="9675257"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_53347"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_53347"/>
    <dbReference type="eggNOG" id="ENOG502QQIE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012066_2_0_1"/>
    <dbReference type="InParanoid" id="C7ZLC3"/>
    <dbReference type="OMA" id="ETHKINC"/>
    <dbReference type="OrthoDB" id="415532at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025340">
        <property type="entry name" value="DUF4246"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049192">
        <property type="entry name" value="DUF4246_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049207">
        <property type="entry name" value="DUF4246_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119">
        <property type="entry name" value="IFI3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14033">
        <property type="entry name" value="DUF4246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21666">
        <property type="entry name" value="DUF4246_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4246" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4246" evidence="1">
        <location>
            <begin position="63"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU35214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="574" mass="66634" checksum="46417F4DC7101200" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLX4</accession>
    <name>C7ZLX4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_78510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698948">
        <property type="protein sequence ID" value="EEU34949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040662.1">
        <property type="nucleotide sequence ID" value="XM_003040616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLX4"/>
    <dbReference type="GeneID" id="9679116"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78510"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78510"/>
    <dbReference type="eggNOG" id="ENOG502RX9H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027816_3_1_1"/>
    <dbReference type="InParanoid" id="C7ZLX4"/>
    <dbReference type="OMA" id="CIQPMGA"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF683">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="53"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU34949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="471" mass="50403" checksum="7B05EAC18C529D1E" modified="2009-10-13" version="1">MDSSKTEKSQYDLEAPTPLNATVSQVGEVSKEQEVDAVFGAVTDHGPNYRALGWIGTVALMLKTQIGLGVLSLPHAFHTLGMIPGAILLVAVAAIATWTSYIVGVFKLNHRDVYGIDDAGYLMFGRVGRELFAIAFCLYWIFVAGSGMLGISIGLNAMSVHGTCTAVFVAVAAISGFLLASIRTLGRISWLAWVGLAFILTSVFVVTISVGIQDRPADAPQTGPWESDWQLIGHPTFSQGVAAVSTLIFACSATSAYFAIVCEMRDPRDFSKSVITAQVISTIVYLIVAVVVYYFCGSAVASPALGSAGPLIKKIAYGLALPGLLVTTTICLHLPAKYFMVRILRGSEHLTANSLVHWCTWLGCTGGSTLIAYVIASGIPVFGDLVSLIGALLGFCLAYQPTGCMWLYDNWGRQNRDWKWKVMVAWCVFIIVLGSFMTVSGTYGSIVNIIDSLKNSGGTKPWTCADNSNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZM38</accession>
    <name>C7ZM38_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-polygalacturonase</fullName>
            <ecNumber evidence="3">3.2.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Pectinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">NECHADRAFT_39724</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(1,4-alpha-D-galacturonosyl)n+m + H2O = (1,4-alpha-D-galacturonosyl)n + (1,4-alpha-D-galacturonosyl)m.</text>
            <dbReference type="EC" id="3.2.1.15"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.15" evidence="3"/>
    <dbReference type="EMBL" id="GG698949">
        <property type="protein sequence ID" value="EEU34928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040641.1">
        <property type="nucleotide sequence ID" value="XM_003040595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZM38"/>
    <dbReference type="SMR" id="C7ZM38"/>
    <dbReference type="FunCoup" id="C7ZM38">
        <property type="interactions" value="146"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZM38"/>
    <dbReference type="GeneID" id="9679027"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_39724"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_39724"/>
    <dbReference type="eggNOG" id="ENOG502QTAW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040116_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZM38"/>
    <dbReference type="OMA" id="WTGNSIT"/>
    <dbReference type="OrthoDB" id="1546079at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000002">
        <property type="entry name" value="Endopolygalacturonase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050434">
        <property type="entry name" value="Glycosyl_hydrlase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884:SF1">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 15 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002987233" description="endo-polygalacturonase" evidence="16">
        <location>
            <begin position="18"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEU34928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="360" mass="37262" checksum="D79D4BF318DFBBF8" modified="2009-10-13" version="1">MISPLFMLAGFAASALALPTALEARAGCTFTDAASAIKGKASCSTIILNNIAVPAGTTLDLTKLKDGTHVIFQGKTTFGYKEWEGPLIAFTGNNLLIEGASGHSIDCQGQRWWDTKGSNGGKTKPKFFSAHSLKNSNIKNLNVLNTPVQAFSINGVTNLGVYGVHMDNSLGDTQGGHNTDAFDVGSSTGVYISGAVVKNQDDCLAINSGTNITFTGGNCSGGHGLSIGSVGGRSDNVVKTVRILNSVIANSDNGVRIKTVYGATGSVSDVKYDTITLQNIAKYGIVIEQDYDNGSPKGVPSAGVPITDVTINKVTGTVKSSGTDIYILCASCKNWTWTGNKVTGGKTSDKCKGVPTGASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMK7</accession>
    <name>C7ZMK7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_82410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698953">
        <property type="protein sequence ID" value="EEU34768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040481.1">
        <property type="nucleotide sequence ID" value="XM_003040435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMK7"/>
    <dbReference type="STRING" id="660122.C7ZMK7"/>
    <dbReference type="GeneID" id="9678927"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82410"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82410"/>
    <dbReference type="eggNOG" id="ENOG502R1VK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_379960_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZMK7"/>
    <dbReference type="OMA" id="WASINGI"/>
    <dbReference type="OrthoDB" id="5362512at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="321"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="729" mass="81958" checksum="E64153AE83806D2D" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMW0</accession>
    <name>C7ZMW0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_15414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698959">
        <property type="protein sequence ID" value="EEU34653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040366.1">
        <property type="nucleotide sequence ID" value="XM_003040320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMW0"/>
    <dbReference type="STRING" id="660122.C7ZMW0"/>
    <dbReference type="GeneID" id="9678775"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_15414"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_15414"/>
    <dbReference type="eggNOG" id="ENOG502S0C8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013866_6_0_1"/>
    <dbReference type="InParanoid" id="C7ZMW0"/>
    <dbReference type="OMA" id="GCYVCRR"/>
    <dbReference type="OrthoDB" id="2991872at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="40072" checksum="627D149C9D50DA3A" modified="2009-10-13" version="1" fragment="single">LPRTIIRQPTQSHDNVSLSYFVRRFVSPDEGDGFPGHFTFLPDLYDHYKHGLLETATLSVAQMAAYNQFGGEELRTHSFRNYGRAIRSLQESIQTDSQAIDDKVIATILLLCTFKARDISGEGLGDPKEHAPGLFYLLEKRGPCQIGTRRGAELFLLAHLRLVSRRQIYSFLHEDDTYTDPGAIATVMGLFDPLLRALSMMSRTLSLRHRLSKHMDRAEPEDEQLLLQECFDMLDQFHVWDQEAPSYWHSTFEGRAAPTVLGEMSSRMTYCDSETACIIILIRSALLILLLTMLAYHSQLQLVQETEDNSHHDFWAECIPILESDVRKAIDDMLTSVPFALGDVDSTGRPTTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNP2</accession>
    <name>C7ZNP2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_85459</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039737.1">
        <property type="nucleotide sequence ID" value="XM_003039691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNP2"/>
    <dbReference type="GeneID" id="9677860"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85459"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85459"/>
    <dbReference type="eggNOG" id="ENOG502T4EI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_860772_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZNP2"/>
    <dbReference type="OrthoDB" id="5106500at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861">
        <property type="entry name" value="GLYCOPROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861:SF4">
        <property type="entry name" value="SH3 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G13610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002987266" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU34024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="34791" checksum="79F68DD77AF76A6A" modified="2009-10-13" version="1">MDSALSIRIYLVLAFQLWFSVAEPDLVIGYFVESGTITCPNSGTFNWSPQHSWANCEPLAPASNGWVVGKSCASLDSFDTEGVIVFLYATSFPDDISRLSYDKPSSFERCETDNACTTVTLYESYNGGEGESPHYLISCKNMIGMGSRDSFATLFLENPTTYETTIATETETDDTSSKPTEKSRPSTASPPTTTETEGTDDQDSGDELSAGVIAGIAVGSVAGVVLVVCAIIIAFRMGRKKGRQGDHETRSKSLADRLKSFPRPALVWRRPDATKGGTETSIEPKAELPASSEVQRPTDALPYTNAEAQSEARTRGSATELPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZP92</accession>
    <name>C7ZP92_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_85638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040019.1">
        <property type="nucleotide sequence ID" value="XM_003039973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZP92"/>
    <dbReference type="GeneID" id="9677658"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85638"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85638"/>
    <dbReference type="HOGENOM" id="CLU_1468565_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZP92"/>
    <dbReference type="OrthoDB" id="5019895at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="184" mass="21138" checksum="C1F4A1A28F5790B9" modified="2009-10-13" version="1">MGRLRDVIGHHSCDASVERPRVRYWVHQVGYTPQPYLGGKDKSMPRHRCLCRVCLSVNYSAWFKDRSPTIDFNPGYFKTSPNETPRFRCTLTNNVHSNTKKVSVILTEHRAPQTHTRSPSGTSPWENKQPSEQEYKQRIQDWLSDPGLDIQGRLLSGRSRRSTPPRGVRQEGEAVGRKVRQAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPV9</accession>
    <name>C7ZPV9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_55811</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698974">
        <property type="protein sequence ID" value="EEU33947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039660.1">
        <property type="nucleotide sequence ID" value="XM_003039614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZPV9"/>
    <dbReference type="GeneID" id="9667184"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55811"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55811"/>
    <dbReference type="eggNOG" id="ENOG502RVZT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011017_4_1_1"/>
    <dbReference type="InParanoid" id="C7ZPV9"/>
    <dbReference type="OMA" id="ILRIMVA"/>
    <dbReference type="OrthoDB" id="3037908at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF10">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU33947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="533" mass="59705" checksum="C01324E44CE9A674" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQG6</accession>
    <name>C7ZQG6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xaa-Pro dipeptidyl-peptidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_56150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698992">
        <property type="protein sequence ID" value="EEU33743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039456.1">
        <property type="nucleotide sequence ID" value="XM_003039410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQG6"/>
    <dbReference type="GeneID" id="9666974"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_56150"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_56150"/>
    <dbReference type="eggNOG" id="ENOG502SH88">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015590_3_0_1"/>
    <dbReference type="InParanoid" id="C7ZQG6"/>
    <dbReference type="OrthoDB" id="2578740at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00976">
        <property type="entry name" value="CocE_NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF10">
        <property type="entry name" value="COCE_NOND FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase C-terminal" evidence="2">
        <location>
            <begin position="312"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU33743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="561" mass="62664" checksum="3213FC552CA0A949" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQK4</accession>
    <name>C7ZQK4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_56206</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="GG698998">
        <property type="protein sequence ID" value="EEU33712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039425.1">
        <property type="nucleotide sequence ID" value="XM_003039379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQK4"/>
    <dbReference type="STRING" id="660122.C7ZQK4"/>
    <dbReference type="ESTHER" id="nech7-c7zqk4">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="9666945"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_56206"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_56206"/>
    <dbReference type="eggNOG" id="KOG4389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_10_6_1"/>
    <dbReference type="InParanoid" id="C7ZQK4"/>
    <dbReference type="OMA" id="STMHAPR"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012565014" description="Carboxylic ester hydrolase" evidence="4">
        <location>
            <begin position="16"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="21"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU33712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="584" mass="62954" checksum="B10D0919632D6A43" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQM5</accession>
    <name>C7ZQM5_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_89251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699002">
        <property type="protein sequence ID" value="EEU33685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039398.1">
        <property type="nucleotide sequence ID" value="XM_003039352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQM5"/>
    <dbReference type="STRING" id="660122.C7ZQM5"/>
    <dbReference type="GeneID" id="9666918"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89251"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89251"/>
    <dbReference type="HOGENOM" id="CLU_096918_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZQM5"/>
    <dbReference type="OMA" id="PISREWV"/>
    <dbReference type="OrthoDB" id="4157259at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU33685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="101" mass="10898" checksum="BA2AE8D2CC72A78F" modified="2009-10-13" version="1">MPSSIAISAGPSATPYHRSPKRTSSSANSSSLSSPSSAPPSAGKDKALHTRRPTLVTRASPRIQIFLPSYVDCDYVLLENRRDPIHAILISDEESKNLLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZR74</accession>
    <name>C7ZR74_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_56578</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="GG699039">
        <property type="protein sequence ID" value="EEU33484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039197.1">
        <property type="nucleotide sequence ID" value="XM_003039151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZR74"/>
    <dbReference type="STRING" id="660122.C7ZR74"/>
    <dbReference type="GeneID" id="9666716"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_56578"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_56578"/>
    <dbReference type="eggNOG" id="KOG0975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031922_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZR74"/>
    <dbReference type="OMA" id="KATRREN"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF69">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU33484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="383" mass="42300" checksum="AF635188CBA95E2A" modified="2009-10-13" version="1">MHRDLVPECEQGPVPAADDPVRFTQKATTAHMVKVRWTAENGWENAEMVPYGKISLEPTASVLHYATETFEGMKVYRGYDNKLRLFRPQLNCVRMLRSNARVALPSFSPQGLLDVITSYVATECPRWLPEPGTNIYLRPAMIGSGEALGISVPAEALFFLFAALFPQASKAPHPGVKLLASSSDIIRAWPGGFGNAKVGASYGPAMAAHGRAREEGCGQTLWLFGPEKYVTEAGASNFFVIWKRKDTQQLELVTSSLDTGVILPGVTRQSVLEIARERLAKDTASQWSDLEPLEVVERPLTMDEIAEAHTDGRLVECFVSGTAMFITPVSCIRYDDTDVSFPMTVTSAGTKTPLCQYSAKIKSWLEDIIYGRVEHEWGHVIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZRC5</accession>
    <name>C7ZRC5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PD-(D/E)XK nuclease-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_4538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699060">
        <property type="protein sequence ID" value="EEU33432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039145.1">
        <property type="nucleotide sequence ID" value="XM_003039099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZRC5"/>
    <dbReference type="GeneID" id="9666669"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_4538"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_4538"/>
    <dbReference type="eggNOG" id="ENOG502R6E6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027219_5_1_1"/>
    <dbReference type="InParanoid" id="C7ZRC5"/>
    <dbReference type="OMA" id="QRTIWRV"/>
    <dbReference type="OrthoDB" id="5244165at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046797">
        <property type="entry name" value="PDDEXK_12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20516">
        <property type="entry name" value="PDDEXK_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PD-(D/E)XK nuclease-like" evidence="1">
        <location>
            <begin position="77"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU33432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="336" mass="38174" checksum="A0ECE30120A0A863" modified="2009-10-13" version="1" fragment="single">SDAPTSRRGRPKSPVKSNNNLQALDVPVDVLQLDMNGIDILPSSVHDLYRRLQDIDDKENFIPWEINQNIKSIIPDRIKDRWFFGQKDENNTEKLTAANRELEFLREIESDAKQCKLSDCSEASWNMWVHMPVLRHALAGYPAIRVEPSTSAKIAPCFVPTTKGKATVVESKMIDFTLLLWLNKGSPRSTPHDPVPPEADGRLMARIANKVWAQERDVQFVNQSSYAPLQYAPIACNIETKTATSSNQGKLQLSVWTAAWFKRMTELLPHAKMPTIPLIHVVGHEWHISFASFHGSHIEVAEELSIGDTRTLLGLYQLVASLRRLGDWIETTYRKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-04-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>H6D5E2</accession>
    <name>H6D5E2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADH-ubiquinone oxidoreductase chain 4</fullName>
            <ecNumber evidence="7">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nad4</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="9"/>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="2" last="14">
            <title>Comparative analysis of Fusarium mitochondrial genomes reveals a highly variable region that encodes an exceptionally large open reading frame.</title>
            <authorList>
                <person name="Al-Reedy R.M."/>
                <person name="Malireddy R."/>
                <person name="Dillman C.B."/>
                <person name="Kennell J.C."/>
            </authorList>
            <dbReference type="PubMed" id="22178648"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2011.11.008"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
            <strain evidence="9">MpVI</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Mitochondrion membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="7"/>
    <dbReference type="EMBL" id="JN041209">
        <property type="protein sequence ID" value="AEJ72899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H6D5E2"/>
    <dbReference type="STRING" id="660122.H6D5E2"/>
    <dbReference type="InParanoid" id="H6D5E2"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_TM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:quinone oxidoreductase/Mrp antiporter transmembrane" evidence="8">
        <location>
            <begin position="128"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEJ72899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="485" mass="54246" checksum="C1A1717F1E5DB0E0" modified="2012-04-18" version="1">MLLSSLITIPVLGTIIVASIGSYKKNSELYAKTIALTSSIINLVISLVIYILFNNSTNQFQYVQEHYNVQLFDIYLGVDGISIYFILLTTIIMPIALLSNWDSIKENVKSYLIIMLLLETLLLVVFMSLDIMLFYIFFESILPPLFILIGLFGSDNKVSASYYLFLYTLWGSLFLLLSILSTSSIMGSTDFDTLFKLNFEYKTQIFLFIGIFIAFAVKTPTIFLNNWLLKAHVESPLGGSIVLAGIVLKLSLYGIFRLILPILPKASLDYTFVIFTIAVITIIYASFSTLRTTDVKELIAYSSVCHASVYLIGIFSNTIQGLEGSVILGLAHGFVSSGLFICAGGVLYDRTGTRLIYFYRGVTQLMPIFAILFFILALGNCGAPLTLNFIGEFMSLYSIVERLPVLGVFACSSVVFSAAYTIYMFNRISFGGSFSRFLEESIYDVNKREFILLFILVLFTVILGIYPSLILNVLDYSMNSLIYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHE4</accession>
    <name>C7YHE4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitin deacetylase</fullName>
            <ecNumber evidence="4">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_105823</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="4"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053618.1">
        <property type="nucleotide sequence ID" value="XM_003053572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YHE4"/>
    <dbReference type="STRING" id="660122.C7YHE4"/>
    <dbReference type="GeneID" id="9664486"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_105823"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_105823"/>
    <dbReference type="eggNOG" id="ENOG502S9C4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021264_3_0_1"/>
    <dbReference type="InParanoid" id="C7YHE4"/>
    <dbReference type="OMA" id="PNNYFRP"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10958">
        <property type="entry name" value="CE4_NodB_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF137">
        <property type="entry name" value="4-DEOXY-4-FORMAMIDO-L-ARABINOSE-PHOSPHOUNDECAPRENOL DEFORMYLASE ARND-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="3" id="KW-0170">Cobalt</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="6">
        <location>
            <begin position="51"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU47905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="248" mass="28223" checksum="56E4222C55E38E23" modified="2009-10-13" version="1">MATLIALIVLVGLLVFPFYSAYCIYKPPRFLIGWLRRKYPDVLFEETTDQKIIALSIDDAPSAHTDEIMQVLQENDAHATFFVIGSQVEGRKDKLVKLVKNGHELGNHAMHDEPSRSLSNEQLLKEVHMVKEMLTEAYAANGKILNNNYFRPGSGLFNWRMRDVLGNQGFRITLGSVYPHDPQIPYPDTNAKHILSMAHPGAIIICHDRRSWTLPMLRIVLPELKRQGYKIVTITELVKSVSSQNLMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHS1</accession>
    <name>C7YHS1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Replication factor C subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_90220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054403.1">
        <property type="nucleotide sequence ID" value="XM_003054357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YHS1"/>
    <dbReference type="FunCoup" id="C7YHS1">
        <property type="interactions" value="844"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YHS1"/>
    <dbReference type="GeneID" id="9664634"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90220"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90220"/>
    <dbReference type="eggNOG" id="KOG2035">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042324_5_0_1"/>
    <dbReference type="InParanoid" id="C7YHS1"/>
    <dbReference type="OMA" id="LKADIMH"/>
    <dbReference type="OrthoDB" id="761538at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000030">
        <property type="entry name" value="replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000002">
        <property type="entry name" value="Replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000136">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF1">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13177">
        <property type="entry name" value="DNA_pol3_delta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22534">
        <property type="entry name" value="RFC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="34"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00070185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU48690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="352" mass="39693" checksum="0C5C1E741871A980" modified="2009-10-13" version="1">MALIVDKHRPRSLDSLTYHHELSSRLQSLAQSGDFPHLLVYGPSGAGKKTRIVATLKELYGPGVEKIKIDARVFQTTGNRKLEFNIVASIYHLEITPSDVGNYDRVVVQDLLKEVAQTQQVDQSAKQRFKVVVINEADHLTRDAQAALRRTMEKYSPNLRLILLANSTANIIAPIRSRTLLVRVAAPTHEEICDVLAVSAKKEGWPVVKGLHQRIAEESGRNLRRALLMYEAVHAQNEKVTDSTPIPPADWEALIGQIAKEILEEHTPARILQVRSKLYDLLTHCIPPTTILKTLAFKLIALIDDGLKGEVIQWAAFYEHRIKTGTKVIFHLEAFVAKFMRIVEMYLMSMDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHW8</accession>
    <name>C7YHW8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_75112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054419.1">
        <property type="nucleotide sequence ID" value="XM_003054373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YHW8"/>
    <dbReference type="FunCoup" id="C7YHW8">
        <property type="interactions" value="46"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YHW8"/>
    <dbReference type="GeneID" id="9674651"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75112"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75112"/>
    <dbReference type="eggNOG" id="ENOG502QQFN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054590_1_0_1"/>
    <dbReference type="InParanoid" id="C7YHW8"/>
    <dbReference type="OMA" id="CATCFFP"/>
    <dbReference type="OrthoDB" id="58297at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562:SF2">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU48706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="283" mass="31038" checksum="F14A6602A858D49D" modified="2009-10-13" version="1">MLIKESHIDVPTSANGKDSTMRIFVFHPTIPGYPNARFPGVCLFSEIYQVTGPVARFARQIAGQGYIVAAPSSYHDFTGPEPLKYDVEDTDRGNKFKIEKTLESYDADSYATVDHLLSLPTCTGLVGATGMCLGGHLAVRAALDPRISACVAYFATDIHSRTLGPYDAPNTSSTAPEYSNHTLDLFNNFKGEVAMIFGVKDTHVPDAGRDLIRAKLREAGVVTSFYEFAWAQHAFIRDELSKGRYDPAITKICFEVLLELFGRVLKTDLGAKDGNVPPPEHIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7YI59</accession>
    <name>C7YI59_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_98915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054459.1">
        <property type="nucleotide sequence ID" value="XM_003054413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YI59"/>
    <dbReference type="GeneID" id="9664511"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_98915"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98915"/>
    <dbReference type="eggNOG" id="ENOG502QVDR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038276_0_0_1"/>
    <dbReference type="InParanoid" id="C7YI59"/>
    <dbReference type="OMA" id="IMGRRNK"/>
    <dbReference type="OrthoDB" id="4084551at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028000">
        <property type="entry name" value="Pma1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14610">
        <property type="entry name" value="Psg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988329" evidence="3">
        <location>
            <begin position="19"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU48746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="375" mass="41493" checksum="4415620939CF89A7" modified="2009-10-13" version="1">MHASKILASVGLVASASASVVRYANVNQQRDVVIEKRADQTAAWVSVDDEAQPATTYTPSMTVVDGVTSIVDGAPHDLTATVYTSTYYGEIYTSTGEPPNPTATGKHGEGVFTRCHNKDGSNAPFCSPYENSTLTTGKTYFITWDPDYFEDKNADNTTAAMMVFARLDIYNTTSEEYQKEGDDFDQVPAAFGFWPFNVKDSYRKFGGDHNISITLYSQRNHTAEKKKASTIYLNVASPQLPAHKEPKVPHGQTLVIALPVVLGSIFLLLIGVCLWNRKTRRIGLGNIMSRGRHGYTGRAERRLFGRKDNGIQLDTRDMPPPGEYRDAPENRRRDSDGLGSLAGSPVDPSFAQQGTTGGHNAFRDEMRRQDQERRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIF5</accession>
    <name>C7YIF5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_102392</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053801.1">
        <property type="nucleotide sequence ID" value="XM_003053755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIF5"/>
    <dbReference type="FunCoup" id="C7YIF5">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YIF5"/>
    <dbReference type="GeneID" id="9676429"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102392"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102392"/>
    <dbReference type="eggNOG" id="ENOG502QT50">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079101_0_0_1"/>
    <dbReference type="InParanoid" id="C7YIF5"/>
    <dbReference type="OMA" id="LWMDMVE"/>
    <dbReference type="OrthoDB" id="1915122at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040153">
        <property type="entry name" value="Rcf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018:SF3">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="6">
        <location>
            <begin position="88"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU48088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="231" mass="25979" checksum="083BD65C59FB73C3" modified="2009-10-13" version="1">MKILTKEEEEAHYAAVVKGGLIGGTIGIGVGVGGVIFASRRYAAFRGLTIPFRTFLITSAGTFGAIINADRWSMAFQKEQNPMNFYQDETQRVQQITRENQSAYERFMEYGKENRYSIVFISWLASMGLAFALVSRSPMNTANKVVQARVYAQGLTLAVLIISAVFEMNDAKSGSGRWQTVMVIDPDDPEHKHLIEKRIHKEEYEGQDLWKDMVAAEERRLAAKKASETKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIG7</accession>
    <name>C7YIG7_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_75316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Nectriaceae</taxon>
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        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EEU48801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="nhe:NECHADRAFT_75316"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="5102069at2759"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
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            <begin position="315"/>
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            <begin position="358"/>
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        </location>
    </feature>
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            <begin position="388"/>
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        <location>
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        </location>
    </feature>
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        <source>
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        </source>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="EEU48801.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="949" mass="104876" checksum="3E57B965BA39CFFA" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
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                <person name="Salamov A."/>
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                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
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        <property type="project" value="UniProtKB-KW"/>
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</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rodriguez-Carres M."/>
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                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
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                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
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            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="KEGG" id="nhe:NECHADRAFT_57694"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_57694"/>
    <dbReference type="eggNOG" id="ENOG502SM1Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022339_0_0_1"/>
    <dbReference type="InParanoid" id="C7YIZ3"/>
    <dbReference type="OMA" id="IWVPVWG"/>
    <dbReference type="OrthoDB" id="5281682at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU48178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="554" mass="62471" checksum="1E21738B682D4B10" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJ25</accession>
    <name>C7YJ25_FUSV7</name>
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        <recommendedName>
            <fullName evidence="8">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_30919</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053907.1">
        <property type="nucleotide sequence ID" value="XM_003053861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJ25"/>
    <dbReference type="STRING" id="660122.C7YJ25"/>
    <dbReference type="GeneID" id="9676543"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_30919"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_30919"/>
    <dbReference type="eggNOG" id="KOG0468">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_11_2_1"/>
    <dbReference type="InParanoid" id="C7YJ25"/>
    <dbReference type="OMA" id="YIFRPIR"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04098">
        <property type="entry name" value="eEF2_C_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04090">
        <property type="entry name" value="EF2_II_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01683">
        <property type="entry name" value="EF2_IV_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04167">
        <property type="entry name" value="Snu114p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000004">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000029">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000009">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000001">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001452">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031950">
        <property type="entry name" value="EFTUD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044121">
        <property type="entry name" value="Snu114_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035655">
        <property type="entry name" value="U5-116kDa_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF6">
        <property type="entry name" value="116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16004">
        <property type="entry name" value="EFTUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="129"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU48194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="983" mass="110032" checksum="F1DD947D8C80300A" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJE2</accession>
    <name>C7YJE2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_75647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
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        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053971.1">
        <property type="nucleotide sequence ID" value="XM_003053925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJE2"/>
    <dbReference type="GeneID" id="9663828"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75647"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75647"/>
    <dbReference type="eggNOG" id="ENOG502TERF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_630198_0_0_1"/>
    <dbReference type="InParanoid" id="C7YJE2"/>
    <dbReference type="OMA" id="CEVAIFT"/>
    <dbReference type="OrthoDB" id="5026096at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU48258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="47691" checksum="656A2ABCF92E00B6" modified="2009-10-13" version="1">MQVQPNPESPTSRRLSQIDGLLAGFNVLASDCPIDRQKQPWVRLEELRGDMQRQWEHLRDVPLAVDDLEGFCETALFAYRNALAGLVPVDLPKVVGLCSLSYAVSRILERDGTSPSETFLDDVQVCLKSVEMEEDRQMIEVVMAKTWPVQADQDSHVGSGTMATHQDQDWAYYPSSHASTYPSATSSEPWQIQATSCLPYSSTASGFGGLVGGLPVSANWAQTTQRPFEQFDAAVDTADYLPLSLIPIPSAPWPGPDQVGLQVGSYGQLEATSQQTAVSSAPSDRPQHLQDTELFKAIGSFLDGSSDFLVLLSGNGVTAKNLDSCLSSNQERSTDKECLQSLYMDPLLKRQEFSQAPCSTILSITKKFVGYGFLQSVDEAQSYMTAVAKECRCSAPTKKGSVKCPDCNKIFPRKWNMKRHQKKNQCPASRAAGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7YK57</accession>
    <name>C7YK57_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_98672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053397.1">
        <property type="nucleotide sequence ID" value="XM_003053351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YK57"/>
    <dbReference type="GeneID" id="9676729"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_98672"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98672"/>
    <dbReference type="eggNOG" id="ENOG502RXHE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037541_0_1_1"/>
    <dbReference type="InParanoid" id="C7YK57"/>
    <dbReference type="OMA" id="RFPQDSY"/>
    <dbReference type="OrthoDB" id="5330253at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018809">
        <property type="entry name" value="DUF2406"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28186">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28186:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10295">
        <property type="entry name" value="DUF2406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU47684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="541" mass="61187" checksum="EDC414410AC82D3A" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7YKM6</accession>
    <name>C7YKM6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_90016</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053479.1">
        <property type="nucleotide sequence ID" value="XM_003053433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YKM6"/>
    <dbReference type="STRING" id="660122.C7YKM6"/>
    <dbReference type="GeneID" id="9664271"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90016"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90016"/>
    <dbReference type="eggNOG" id="ENOG502S3E1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014148_1_0_1"/>
    <dbReference type="InParanoid" id="C7YKM6"/>
    <dbReference type="OMA" id="AFMMNQL"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="603"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU47766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="824" mass="93411" checksum="29F95FBDCEE93694" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7YKX4</accession>
    <name>C7YKX4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_77327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052867.1">
        <property type="nucleotide sequence ID" value="XM_003052821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YKX4"/>
    <dbReference type="GeneID" id="9670938"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77327"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77327"/>
    <dbReference type="eggNOG" id="KOG0742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004471_6_3_1"/>
    <dbReference type="InParanoid" id="C7YKX4"/>
    <dbReference type="OMA" id="SKWFRLA"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056599">
        <property type="entry name" value="AAA_lid_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23232">
        <property type="entry name" value="AAA_lid_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="1">
        <location>
            <begin position="581"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU47154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="844" mass="96667" checksum="027F6AF17EC6CFF9" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7YL13</accession>
    <name>C7YL13_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small nuclear ribonucleoprotein Prp3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_35849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052426.1">
        <property type="nucleotide sequence ID" value="XM_003052380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YL13"/>
    <dbReference type="GeneID" id="9671418"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_35849"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_35849"/>
    <dbReference type="eggNOG" id="ENOG502S0MQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064566_0_0_1"/>
    <dbReference type="InParanoid" id="C7YL13"/>
    <dbReference type="OMA" id="IDAYMSF"/>
    <dbReference type="OrthoDB" id="432412at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd24163">
        <property type="entry name" value="RWDD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017359">
        <property type="entry name" value="Phi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059181">
        <property type="entry name" value="RWDD2A-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955:SF10">
        <property type="entry name" value="DUF1115 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G14750)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955">
        <property type="entry name" value="RWD DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038021">
        <property type="entry name" value="UCP038021_RWDD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small nuclear ribonucleoprotein Prp3 C-terminal" evidence="1">
        <location>
            <begin position="169"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU46713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="295" mass="32718" checksum="3FA91A8A3C87C44E" modified="2009-10-13" version="1">MPAEENGPGVLPKDLMVLQLGQIDLLMAMYESDNAISIDASSSTLLETLRDWCENDGEMPKFTQLSINMLLTLEISEEGQTKSLQLHLSVPLVDQGEGTADEPPPVKTRIQQPDWMSKGEVAALTAEIPKEDILTVIEYVKDAAAQHLTAQAQTNHDALSTDKSTVRVWFYFPSISTRAKRDDLVNYSPTYGLTGFLLAGKPGILCLEGGSQAIDDFMKFIKTESWGDIPAHHKKVSERYREDGPDVKRAFVDMQEITDTVGEKRGERANRSDMRAIEAWLNEKGVGEAFAKVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLG4</accession>
    <name>C7YLG4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_91694</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052969.1">
        <property type="nucleotide sequence ID" value="XM_003052923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YLG4"/>
    <dbReference type="FunCoup" id="C7YLG4">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="GeneID" id="9671027"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_91694"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_91694"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_5_0_1"/>
    <dbReference type="InParanoid" id="C7YLG4"/>
    <dbReference type="OMA" id="GWAINSI"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF3">
        <property type="entry name" value="POLYAMINE TRANSPORTER TPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU47256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="52373" checksum="BC48178252BEDA23" modified="2009-10-13" version="1">MGSSTQLGYAAELPKTLSMMSILGMSFAIMAVPFGLSTTFYITLVNGQAVTIIWGWVLVSLISLSIAASLAEICAVYPTAGGVYYWSAILSTPKYAPAVSFIDGWMTLVGNWTVTLSINFSGAQLILSAITIFNEDFVPNEWQTVLCFWAVMLVAALINAFGSKYLDLFNKLCIYWTGASVVIILVTLLVMADTRRSADFVFGHFDASASGWPGGWSFFVGLLQAAYTLTGYGMVAAMCEEVQNPEREVPKAMVLSVVAAGLTGVVYLVPVLFVLPDVTALLASSQPIGLLFKTVTGSAAGGFGLLFLILGIWLFAGVGALTAASRCTYAFARDGGIPGNLWAKVNKTLDVPLWAIILSTAVDCLLGCIYFGSSAAFGSFTGVATICLSASYCVPILVSVVRGRQAVRSSPFPLGKLGYVLNYISLVWICLAVVIFCMPVSLPVTPSSMNYASVVFAGFGAISGVWYIVYARKHFKGPIIMDMAREGVEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLR3</accession>
    <name>C7YLR3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_99566</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053030.1">
        <property type="nucleotide sequence ID" value="XM_003052984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YLR3"/>
    <dbReference type="STRING" id="660122.C7YLR3"/>
    <dbReference type="GeneID" id="9663796"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_99566"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_99566"/>
    <dbReference type="eggNOG" id="ENOG502QRAF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038067_0_0_1"/>
    <dbReference type="InParanoid" id="C7YLR3"/>
    <dbReference type="OMA" id="KVGNAFH"/>
    <dbReference type="OrthoDB" id="2264563at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046868">
        <property type="entry name" value="BAR_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046869">
        <property type="entry name" value="SLM1/RGC1-like_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941:SF1">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20400">
        <property type="entry name" value="BAR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20399">
        <property type="entry name" value="PH_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="301"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="413"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU47317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="477" mass="52018" checksum="616AD9E29ECADAB3" modified="2009-10-13" version="1">MASPTTSNLPSRATTGLSAFSDDAIPEVDPSTTAGLLAERLQAWKHAVGYLEEYMKAMEKIHGHHAKEYEKALKTISNPLKEGHHFDQSLGGIAGFFENMRSNTQSMINTNIETEKSIKGSVLPVLERLHKEIKHKAKELAHGAEKGAKEVEKARNTTQKHIELLGQQAAAFDSAGGHLNSNDDPYVVYRGVLHRLNAQVITENNHRNDLLAVQNNFSTFESHVIEVVQQAFEAFVQLAGGQAEKTHALHNDMLGSIQRVGPEFEWNAFKDRSADRLVNPNEPARSVEAIQFPNMDHTATRALIEGSLERKSRNKLSWGYSTSYYVVTPSKFLHEFKDSDNNRVDPKPELSVYLPDAVIGTVQGEKFSVKGKDKSKTMSSKLTGSTELQFKAHTAADAQKWFQILSDVGKSTAPLSVGSSPVGSTPTSPNPQGANDNPLDNKLQSPISPAGEHKAQEAGVVGGEVPAATSEKKAEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLV4</accession>
    <name>C7YLV4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_58992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053050.1">
        <property type="nucleotide sequence ID" value="XM_003053004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YLV4"/>
    <dbReference type="STRING" id="660122.C7YLV4"/>
    <dbReference type="GeneID" id="9671086"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_58992"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_58992"/>
    <dbReference type="eggNOG" id="ENOG502SUU9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071100_0_0_1"/>
    <dbReference type="InParanoid" id="C7YLV4"/>
    <dbReference type="OMA" id="RASGWFK"/>
    <dbReference type="OrthoDB" id="5380416at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU47337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="232" mass="24987" checksum="562EAD0DCE2E1641" modified="2009-10-13" version="1">MSSLFNKSGGGSRFQLPALNLNFGSITDGTNIPPPPDSPVQKVPTPPQTPPPVKEVAKETEKDTQSNVVSDDSKETPQQSIPAPSNGNLAGTKRYADEDVPLSPAASSRQGSIRRLFSRTMLNNNYAEGQNQNPSNTNLAAVTNGRPSSQGGSSFLDERKSRRSSGWFRRIRTGDTGSKRISTMNFEEPPRAPTPTATIKKPSGPPPPMIPELTDLEKDEGSLGDDLFKNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7YMM3</accession>
    <name>C7YMM3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_92027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053185.1">
        <property type="nucleotide sequence ID" value="XM_003053139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YMM3"/>
    <dbReference type="STRING" id="660122.C7YMM3"/>
    <dbReference type="GeneID" id="9664101"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_92027"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_92027"/>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009958_6_1_1"/>
    <dbReference type="InParanoid" id="C7YMM3"/>
    <dbReference type="OMA" id="SCLHEHF"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF82">
        <property type="entry name" value="FAMILY CHAPERONE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G08575)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU47472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="542" mass="60487" checksum="7BB1F800A3301A41" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7YMQ0</accession>
    <name>C7YMQ0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_77953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053197.1">
        <property type="nucleotide sequence ID" value="XM_003053151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YMQ0"/>
    <dbReference type="STRING" id="660122.C7YMQ0"/>
    <dbReference type="GeneID" id="9664113"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77953"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77953"/>
    <dbReference type="eggNOG" id="ENOG502RJSR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009310_0_0_1"/>
    <dbReference type="InParanoid" id="C7YMQ0"/>
    <dbReference type="OMA" id="PPDNFMS"/>
    <dbReference type="OrthoDB" id="5417386at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
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        <location>
            <begin position="357"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="555"/>
        </location>
    </feature>
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        <location>
            <begin position="556"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="728"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU47484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="814" mass="91125" checksum="033B23835B4B1AB3" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7YMU0</accession>
    <name>C7YMU0_FUSV7</name>
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        <recommendedName>
            <fullName evidence="2">Wbp11/ELF5/Saf1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_35220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053216.1">
        <property type="nucleotide sequence ID" value="XM_003053170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YMU0"/>
    <dbReference type="STRING" id="660122.C7YMU0"/>
    <dbReference type="GeneID" id="9664207"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_35220"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_35220"/>
    <dbReference type="eggNOG" id="ENOG502S9RI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078580_0_0_1"/>
    <dbReference type="InParanoid" id="C7YMU0"/>
    <dbReference type="OMA" id="MPKERNF"/>
    <dbReference type="OrthoDB" id="5597581at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019007">
        <property type="entry name" value="Wbp11/ELF5/Saf1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09429">
        <property type="entry name" value="Wbp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU47503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="266" mass="29920" checksum="223EE80C88597DEE" modified="2009-10-13" version="1">MAKERNYNPVQAQRKADKVKAIKKGKAEQQGRRNEKLARKNPDRIQKQIDDLKKITSSGGKLTRHEEQVLEGLEKEIRAVRKARDTLGDNAPTFGRGFNRDRDSGAGVLGKRRRGSNDATTSDEEVPDDIKSIPMPRDTPPPIPKDVMDKWWAERRARRAAENPRQDEGDRPPKKEAPPVEAKTVYEAKPIVRDLRKEAVSAFVPTAVKLKMSKGQGQGGLMEPEEADRLEKEGYLKTGDNDASRQAERGPPSRHVTMEEVEDEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNC2</accession>
    <name>C7YNC2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_59450</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052811.1">
        <property type="nucleotide sequence ID" value="XM_003052765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNC2"/>
    <dbReference type="GeneID" id="9664377"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_59450"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_59450"/>
    <dbReference type="eggNOG" id="ENOG502SEE2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050230_2_0_1"/>
    <dbReference type="InParanoid" id="C7YNC2"/>
    <dbReference type="OMA" id="AFANPIF"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF9">
        <property type="entry name" value="PEROXIDASE STCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="12"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU47098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="271" mass="30072" checksum="513B1522F76807A5" modified="2009-10-13" version="1">MADQDQASEQLAKGTYAPSRPGDLRGPCPLINSLANHGYLPRDGRNVRVEEVLAGMDAVGLSKPLGAVFANPIFNERAPSKFHNDPVPQRTFLQSVWHTISDPWSIFGKFGMRTPGQEDAEGHRVLNLDQLALPNVVEHDISLTRRDHQQGDNRTPQKDLIEDLLASAKDGKALTAQDLGDLRKRRIERQKADNPGCLYGAFEHDLSCAEIALVLNVIGNGSELPCDYARAFFLEERLPIKEGWKAKTTRFGVIALITARNKIKELIGLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNC4</accession>
    <name>C7YNC4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor RfeG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_36283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053311.1">
        <property type="nucleotide sequence ID" value="XM_003053265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNC4"/>
    <dbReference type="STRING" id="660122.C7YNC4"/>
    <dbReference type="GeneID" id="9671345"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_36283"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_36283"/>
    <dbReference type="eggNOG" id="ENOG502SQKQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037532_0_0_1"/>
    <dbReference type="InParanoid" id="C7YNC4"/>
    <dbReference type="OMA" id="TEPPFRD"/>
    <dbReference type="OrthoDB" id="4146887at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39609:SF1">
        <property type="entry name" value="RFEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39609">
        <property type="entry name" value="RFEG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU47598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="39553" checksum="ACC00DD0FEBD670A" modified="2009-10-13" version="1">MSRASRNQHAPTGAGGRQNEYFVPRDGIDREVISADICRYLGNDALVRPGHYENPQTGQVVQGYYITAYRNLTTAMIEDLKADSARWDSERRAQTSRNTSGGIHASRNATGVPPRHSSNSPLVQYRHSETHQSRQHHGPTEGPYQTDPYARDAGFDSTRYPGTGAPGYTGAAGSYTQAYGATSAGAYAGYPQTQQSPPPADARYGSTPASGSVLNQAYQAAQDSYMTMGANRNQRGYAGDPYANQMATSAAAAQQAVYATAAPTTAGYPATAAPYPYSGQVPPAGASSYATMQPQDPFYGRGAYQRHTHPPTRLESTAPQYDETPRARASATPTNTQTNPSGTSSSRRSERESDRHASDRHHRSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNM5</accession>
    <name>C7YNM5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pyruvate dehydrogenase protein x component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_38763</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051857.1">
        <property type="nucleotide sequence ID" value="XM_003051811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNM5"/>
    <dbReference type="FunCoup" id="C7YNM5">
        <property type="interactions" value="115"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YNM5"/>
    <dbReference type="GeneID" id="9670835"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_38763"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_38763"/>
    <dbReference type="eggNOG" id="KOG0557">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035825_2_0_1"/>
    <dbReference type="InParanoid" id="C7YNM5"/>
    <dbReference type="OMA" id="DGIMMKI"/>
    <dbReference type="OrthoDB" id="202158at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF82">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE COMPLEX PROTEIN X COMPONENT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="10"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="6">
        <location>
            <begin position="140"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="94"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU46144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="42069" checksum="FA879E1C40EFB972" modified="2009-10-13" version="1" fragment="single">FTTSTRCFDAQNFTMPALSPTMTEGNIASWKVKEGESFSAGDVLLEIETDKATMDVEAQDDGVMVKIMTADGSKAVQVGSRIAVIAEAGDDISSLEIPADEQPKAQPSQAKETAPTESKPAEKKSAPKPTGTGTYEHKYPLLPSVGHLVKEKGISEDDVKKIKGTGPHGRLLKGDILAYLGAINPDTPAANESNFNSLVHLDLSNIKVAEKKAPKEAPKEAAPAPKAPVIENLELSIPVSLSKVIEVQNKIQDTLGVFLPISTFVGRAAEVANDALPALKRAPTTNELFDQVLGLDKVKAVKGSRGVYLPQISAIPPASLLAPKPAARKQTDIIDILAAPSKKAAPKPATIRTVPGMSSGANIFTLVVPKAEEERAQIFLERCKVILEEEPGRLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNS0</accession>
    <name>C7YNS0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_104215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051877.1">
        <property type="nucleotide sequence ID" value="XM_003051831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNS0"/>
    <dbReference type="STRING" id="660122.C7YNS0"/>
    <dbReference type="GeneID" id="9672956"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_104215"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_104215"/>
    <dbReference type="eggNOG" id="ENOG502SFBR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011833_0_0_1"/>
    <dbReference type="InParanoid" id="C7YNS0"/>
    <dbReference type="OMA" id="ESWQYID"/>
    <dbReference type="OrthoDB" id="4226666at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF5">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="378"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU46164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="815" mass="89824" checksum="58D5F16C75492E06" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNS2</accession>
    <name>C7YNS2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-dehydrosphinganine reductase</fullName>
            <ecNumber evidence="9">1.1.1.102</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_79406</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reduction of 3'-oxosphinganine (3-ketodihydrosphingosine/KDS) to sphinganine (dihydrosphingosine/DHS), the second step of de novo sphingolipid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>sphinganine + NADP(+) = 3-oxosphinganine + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57817"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.102"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:22642"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.1.1.102" evidence="9"/>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052338.1">
        <property type="nucleotide sequence ID" value="XM_003052292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNS2"/>
    <dbReference type="FunCoup" id="C7YNS2">
        <property type="interactions" value="124"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YNS2"/>
    <dbReference type="GeneID" id="9672958"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79406"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79406"/>
    <dbReference type="eggNOG" id="KOG1210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_3_0_1"/>
    <dbReference type="InParanoid" id="C7YNS2"/>
    <dbReference type="OMA" id="ICGVFEE"/>
    <dbReference type="OrthoDB" id="10267115at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047560">
        <property type="term" value="F:3-dehydrosphinganine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006666">
        <property type="term" value="P:3-keto-sphinganine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08939">
        <property type="entry name" value="KDSR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045022">
        <property type="entry name" value="KDSR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550:SF3">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU46625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="349" mass="38171" checksum="8191282FED6BF1B9" modified="2009-10-13" version="1">MDFSSTTILSVLGASVATIIFGTFIMGLFGGNKMPVEGKTVLITGASEGMGLSVAKKLSAKGANIILVARSVGKLEAALAIVQAAAKNPETQRFHYISADVSVPSYAGPLLAEVISWNNGKSPDIVWTIAGMAYPELFIDMEMDSLRRHMDVNFYGTAEMSHAILREWLAPNAPVEKEPKHLIMTSSVVAFYSPPGYGPYAPAKYAMRGLAENISQEVKMYPQNVEVHVVYPGTILSEANKRENEVKPEIAKIVEKDDPQQTPDEVAEKAIQGLENGEYFITVAFLGHLMKWGAFGGASKNNAIVDFFGSLLALFVWVFARIDIDSKIRKYGKVHGHPSTYKRKRPQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNT3</accession>
    <name>C7YNT3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_38592</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052343.1">
        <property type="nucleotide sequence ID" value="XM_003052297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNT3"/>
    <dbReference type="FunCoup" id="C7YNT3">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YNT3"/>
    <dbReference type="GeneID" id="9672964"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_38592"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_38592"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002678_91_1_1"/>
    <dbReference type="InParanoid" id="C7YNT3"/>
    <dbReference type="OMA" id="MLTGEGY"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001102">
        <property type="entry name" value="Transcription factor IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="102"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="192"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="291"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="395"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU46630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="502" mass="56874" checksum="E7FBFCDB574AE1AA" modified="2009-10-13" version="1">MSKRSALEEAPGTPSAKKLHSDDSDDLYIDDPEDDVTTAHTPASMYEPDSPQTVNTAATTPRHKFPSDLKTLACTWPGCPKTFNRPARLRDHLNSHTNSRPFKCQYHGCDKDYIEDKHLKQHIKAVHTLERKHVCPKEGCGKSFVTGTRLKRHQAVHEGEERFRCQDCGQSFRKKETLNKHVRKDHQGLPALQCPEEGCPRAFDSKATLKRHREREHGEAKFWCGECGLKKMPNGTEERVGFTTEVLLQAHIRQEHQNCLFCDFKSGTRWELEKHVEMYHSGQTVEDRKTIACPYAECKKKFTKKSNLNAHIRTAHEGFRFVCGEVDLSSAGLQGWTNDQGCGDKFSTKVRLEDHIRYKHLGLERPKLSKPGPSHQQVDLIDELSGAANQAERKIVCPQCNEAFIRYHDLDVHVEAYHGAPSQADPAMFLSDNQFDANSIPFGSFPGTPAWPGATQEDYIFAAQMDYDTPHDEWPEDEANILLLARDPQTQEPLIDPALGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNX5</accession>
    <name>C7YNX5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small COPII coat GTPase SAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Small COPII coat GTPase sar1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">NECHADRAFT_102593</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051905.1">
        <property type="nucleotide sequence ID" value="XM_003051859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNX5"/>
    <dbReference type="FunCoup" id="C7YNX5">
        <property type="interactions" value="954"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YNX5"/>
    <dbReference type="GeneID" id="9672984"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102593"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102593"/>
    <dbReference type="eggNOG" id="KOG0077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_6_0_1"/>
    <dbReference type="InParanoid" id="C7YNX5"/>
    <dbReference type="OMA" id="GLWNKHG"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007006">
        <property type="term" value="P:mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902953">
        <property type="term" value="P:positive regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070863">
        <property type="term" value="P:positive regulation of protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003400">
        <property type="term" value="P:regulation of COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00879">
        <property type="entry name" value="Sar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000161">
        <property type="entry name" value="Small COPII coat GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006687">
        <property type="entry name" value="Small_GTPase_SAR1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45684">
        <property type="entry name" value="RE74312P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51422">
        <property type="entry name" value="SAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10 22" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 22" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="13 22" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 20" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 22" id="KW-0653">Protein transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 22" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU003926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EEU46192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="189" mass="21551" checksum="C2E904895A5452EF" modified="2009-10-13" version="1">MWIVNWFYDVLSSLGLLNKHAKLLFLGLDNAGKTTLLHMLKNDRVAILQPTLHPTSEELAIGNVRFTTFDLGGHQQARRIWRDYFPEVNGVVFLVDAKDHERFPEAKAELDALLSMEELSKVPFVILGNKIDHPDAVSEDEMRHQLGLYQTTGKGKVQLEGIRPIELFMCSVVMRQGYGDGIRWLSQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNY2</accession>
    <name>C7YNY2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_79465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052368.1">
        <property type="nucleotide sequence ID" value="XM_003052322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNY2"/>
    <dbReference type="STRING" id="660122.C7YNY2"/>
    <dbReference type="GeneID" id="9670890"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79465"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79465"/>
    <dbReference type="eggNOG" id="ENOG502SV8I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032833_0_0_1"/>
    <dbReference type="InParanoid" id="C7YNY2"/>
    <dbReference type="OMA" id="AWRQANM"/>
    <dbReference type="OrthoDB" id="2129362at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU46655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="541" mass="60964" checksum="4E2194F4F5349233" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQ37</accession>
    <name>C7YQ37_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_73588</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051668.1">
        <property type="nucleotide sequence ID" value="XM_003051622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQ37"/>
    <dbReference type="FunCoup" id="C7YQ37">
        <property type="interactions" value="525"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YQ37"/>
    <dbReference type="GeneID" id="9673418"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_73588"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_73588"/>
    <dbReference type="eggNOG" id="KOG3386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079690_4_0_1"/>
    <dbReference type="InParanoid" id="C7YQ37"/>
    <dbReference type="OMA" id="DITEYCH"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF115">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU45955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="164" mass="18729" checksum="F01803CCE7598E0A" modified="2009-10-13" version="1">MDHAHMDHSGMDHKGMGHGDMDHGDGGMKDMCSMNMLFTWDTKNLCIVFRQWHIRSTSSLVFSLVAVILLAVGYEALRSLSRRYEEALDKRVRATPRQNQEQADQRAHLIKAVLYALQNFYAFMLMLVFMTYNGWVMVSVSLGAFIGYVFFGHRTSATKDNACH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQJ2</accession>
    <name>CBPYA_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName>Carboxypeptidase Y homolog A</fullName>
            <ecNumber>3.4.16.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CPYA</name>
        <name type="ORF">NECHADRAFT_100110</name>
    </gene>
    <organism>
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Release of a C-terminal amino acid with broad specificity.</text>
            <dbReference type="EC" id="3.4.16.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.5"/>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051746.1">
        <property type="nucleotide sequence ID" value="XM_003051700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQJ2"/>
    <dbReference type="SMR" id="C7YQJ2"/>
    <dbReference type="FunCoup" id="C7YQJ2">
        <property type="interactions" value="896"/>
    </dbReference>
    <dbReference type="ESTHER" id="fusv7-cbpya">
        <property type="family name" value="Carboxypeptidase_S10"/>
    </dbReference>
    <dbReference type="MEROPS" id="S10.001"/>
    <dbReference type="GlyCosmos" id="C7YQJ2">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="NechaT100110">
        <property type="protein sequence ID" value="NechaP100110"/>
        <property type="gene ID" value="NechaG100110"/>
    </dbReference>
    <dbReference type="GeneID" id="9673570"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100110"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100110"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008523_10_4_1"/>
    <dbReference type="InParanoid" id="C7YQJ2"/>
    <dbReference type="OMA" id="GDWMKPF"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.410:FF:000001">
        <property type="entry name" value="Carboxypeptidase Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008442">
        <property type="entry name" value="Propeptide_carboxypepY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05388">
        <property type="entry name" value="Carbpep_Y_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0121">Carboxypeptidase</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <keyword id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000407455" evidence="1">
        <location>
            <begin position="18"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000407456" description="Carboxypeptidase Y homolog A">
        <location>
            <begin position="125"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="457"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="514"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="503"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="178"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="312"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="381"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="537" mass="60161" checksum="08BE047930A51F10" modified="2009-10-13" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRB0</accession>
    <name>C7YRB0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase epsilon subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA polymerase II subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_93537</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase epsilon subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050760.1">
        <property type="nucleotide sequence ID" value="XM_003050714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YRB0"/>
    <dbReference type="FunCoup" id="C7YRB0">
        <property type="interactions" value="768"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YRB0"/>
    <dbReference type="GeneID" id="9667833"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_93537"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_93537"/>
    <dbReference type="eggNOG" id="KOG3818">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010628_1_0_1"/>
    <dbReference type="InParanoid" id="C7YRB0"/>
    <dbReference type="OMA" id="PEDGAWF"/>
    <dbReference type="OrthoDB" id="10254730at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016266">
        <property type="entry name" value="POLE2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="9">
        <location>
            <begin position="456"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="625"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU45047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="771" mass="83938" checksum="600D85A634AE8B7B" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRM4</accession>
    <name>C7YRM4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">L-2,4-diaminobutyrate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_93620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051199.1">
        <property type="nucleotide sequence ID" value="XM_003051153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YRM4"/>
    <dbReference type="STRING" id="660122.C7YRM4"/>
    <dbReference type="GeneID" id="9665906"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_93620"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_93620"/>
    <dbReference type="eggNOG" id="KOG0628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011856_6_2_1"/>
    <dbReference type="InParanoid" id="C7YRM4"/>
    <dbReference type="OMA" id="SWATDAH"/>
    <dbReference type="OrthoDB" id="2161780at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF165">
        <property type="entry name" value="DECARBOXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU45486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="54173" checksum="91C5AB5F153C349A" modified="2009-10-13" version="1">MSDLFDLDAQRARLSRRHASEPGPGPAPTLPSLSAIKAAEASLPRPDSETYLQGVPQEQVLRHITEDIVPACNGPASSSRYYGFVTGGTLPIAEWADNVVSRVDQNVQVHLPTQTVATTVEDAALEMWAALLGLPGFRGRTFTTGATASNVLGLACGREAVVGKKLGEGETVGELGLLVACMAAGIKELQILTSAGHSSLSKAASVVGFGRASVKELRLSGDEPWRLDIDALERELQRGGVASVIALSAGEVNTGRFALTGVEEMKRVRELADKYGAWIHVDGAFGIFARALPGEDDYKTLHKRVEGLELADSITVDGHKLLNVPYDCGMFLTRTPDILQSVFTNPNAAYLSSGGQSTIPSPLNIGLENSRRFRALPAYAVLLSEGRPGMASLLANMVTLSRRIAAFLRDSEHYELLPDDGAGLDEVFMIVLFRAKDPKLNGELVEKINGTRQMYVSGTSWRGEKAVRVAVSNWMVDVERDFKVVTSILTHVAEGKEFDIENC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRZ4</accession>
    <name>C7YRZ4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein eL8/eL30/eS12/Gadd45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_61313</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050868.1">
        <property type="nucleotide sequence ID" value="XM_003050822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YRZ4"/>
    <dbReference type="SMR" id="C7YRZ4"/>
    <dbReference type="FunCoup" id="C7YRZ4">
        <property type="interactions" value="1191"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YRZ4"/>
    <dbReference type="GeneID" id="9668035"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_61313"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_61313"/>
    <dbReference type="eggNOG" id="KOG2988">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130502_0_1_1"/>
    <dbReference type="InParanoid" id="C7YRZ4"/>
    <dbReference type="OMA" id="YFQGGNN"/>
    <dbReference type="OrthoDB" id="1928736at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048025">
        <property type="term" value="P:negative regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000001">
        <property type="entry name" value="60S ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00481">
        <property type="entry name" value="Ribosomal_eL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000231">
        <property type="entry name" value="Ribosomal_eL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_eL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002172">
        <property type="entry name" value="PRK01018.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00709">
        <property type="entry name" value="RIBOSOMAL_L30E_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00993">
        <property type="entry name" value="RIBOSOMAL_L30E_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="4">
        <location>
            <begin position="13"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU45155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="110" mass="11843" checksum="5B9740052A54B7FE" modified="2009-10-13" version="1">MAPQKKSKKDANSINSKLALVMKSGKVTLGYKSTLKSLRSGKAKLIIIAGNTPPLRKSELEYYSMLSKAPIHHFSGNNIELGTACGKLFRCSTMAILDAGDSDILSDQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7YS75</accession>
    <name>C7YS75_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_80638</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050914.1">
        <property type="nucleotide sequence ID" value="XM_003050868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YS75"/>
    <dbReference type="GeneID" id="9666157"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_80638"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_80638"/>
    <dbReference type="eggNOG" id="ENOG502R60E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_874483_0_0_1"/>
    <dbReference type="InParanoid" id="C7YS75"/>
    <dbReference type="OMA" id="WHIAARA"/>
    <dbReference type="OrthoDB" id="417208at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="306"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU45201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="335" mass="38610" checksum="6447A5F01940865E" modified="2009-10-13" version="1">MAPFPSKLVTAYPPWCEDIGSQNPEPTPKPFALTLPHVIRRNTHLYKTIGEMDDLTDKALKERLTPLCRELQEYQEQDKEQVHGISKALVAKYGECSIRVMCRTWDLYLALTTTPEIPGDDPGILEQTEWLSSIRRFADDFQVISKFQEEGLQSTYVTNVLVQEQSDRIKRAEREREVFQAMHYELTQENLEDMPAYKSTALGEHSLSALRRCVYTAQVFHQALRDRGEEVLENDDEEIKWIYQAKQLWHIAGRAAMSWAPRRQGEIQGILTAYCEDLIVRRRREGYEQDAILRAQLQAILGDTRHGNSYMATEDSNPDEDEDEDAEGKGKENAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7YS78</accession>
    <name>C7YS78_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin-like protein AAED1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_69625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EEU45202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003050869.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="9668148"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_69625"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_69625"/>
    <dbReference type="eggNOG" id="KOG4498">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035338_0_1_1"/>
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    <dbReference type="OrthoDB" id="40334at2759"/>
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        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd02970">
        <property type="entry name" value="PRX_like2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000404">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.14"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PEROXIREDOXIN-LIKE 2C"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="386"/>
        </location>
    </feature>
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        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU45202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="43097" checksum="28B941BBCF7B7BD2" modified="2009-10-13" version="1">MGASNPENLASGPDEKSPIERKTVENVAPEEPSFERAPTLPPRPVSIQSKNEDLDEKALEAGYDEKLPQPNNGFTIHRKPVSNKTPPQSIKIDKSQPEDFEGEVATTNELPPPELLKKIEDYIVLDRHGKSHPFSSLYTGSNVARRVLIIFVRHFFCGNCQEFLRSLSDAVTPEALLRLPVSTFIAVIGCGDPALIDMYVNETNCRFPVYTDPTRSLFHALGMTKTLQMGAKPAYMRKSMTRSIVDSIVQGVKQLPTGNVLKMGDQRQVGGEFLFEPRNILTPVTTPRDEKFQPMDTLEDPQDSAPGRENGRRKDYGDEEKRVTWCHRMKTTRDHAEIPELIEVLGLDVSQSAGRNSVTSARKGKGQSMAQEIRKLSAERARTPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSB2</accession>
    <name>C7YSB2_FUSV7</name>
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        <recommendedName>
            <fullName evidence="7">Ras-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_69644</name>
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    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051317.1">
        <property type="nucleotide sequence ID" value="XM_003051271.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="C7YSB2">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YSB2"/>
    <dbReference type="GeneID" id="9666176"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_69644"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_69644"/>
    <dbReference type="eggNOG" id="KOG3508">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003244_1_0_1"/>
    <dbReference type="InParanoid" id="C7YSB2"/>
    <dbReference type="OMA" id="QKDWTLI"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05137">
        <property type="entry name" value="RasGAP_CLA2_BUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="391"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="4">
        <location>
            <begin position="599"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1000"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1025"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1083"/>
            <end position="1094"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU45604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1094" mass="122792" checksum="CE7F247CE5E580F7" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSL3</accession>
    <name>C7YSL3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11 12">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="4 11 12">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NECHADRAFT_106153</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Sci. Rep." volume="10" first="15658" last="15658">
            <title>High-resolution crystal structure and biochemical characterization of a GH11 endoxylanase from Nectria haematococca.</title>
            <authorList>
                <person name="Andaleeb H."/>
                <person name="Ullah N."/>
                <person name="Falke S."/>
                <person name="Perbandt M."/>
                <person name="Brognaro H."/>
                <person name="Betzel C."/>
            </authorList>
            <dbReference type="PubMed" id="32973265"/>
            <dbReference type="DOI" id="10.1038/s41598-020-72644-w"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.00 ANGSTROMS) OF 30-222</scope>
    </reference>
    <reference evidence="18 19 20" key="3">
        <citation type="journal article" date="2022" name="IUCrJ" volume="9" first="778" last="791">
            <title>Rapid and efficient room-temperature serial synchrotron crystallography using the CFEL TapeDrive.</title>
            <authorList>
                <person name="Zielinski K.A."/>
                <person name="Prester A."/>
                <person name="Andaleeb H."/>
                <person name="Bui S."/>
                <person name="Yefanov O."/>
                <person name="Catapano L."/>
                <person name="Henkel A."/>
                <person name="Wiedorn M.O."/>
                <person name="Lorbeer O."/>
                <person name="Crosas E."/>
                <person name="Meyer J."/>
                <person name="Mariani V."/>
                <person name="Domaracky M."/>
                <person name="White T.A."/>
                <person name="Fleckenstein H."/>
                <person name="Sarrou I."/>
                <person name="Werner N."/>
                <person name="Betzel C."/>
                <person name="Rohde H."/>
                <person name="Aepfelbacher M."/>
                <person name="Chapman H.N."/>
                <person name="Perbandt M."/>
                <person name="Steiner R.A."/>
                <person name="Oberthuer D."/>
            </authorList>
            <dbReference type="PubMed" id="36381150"/>
            <dbReference type="DOI" id="10.1107/s2052252522010193"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.51 ANGSTROMS) OF 34-222</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11 12">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4 11 12"/>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050975.1">
        <property type="nucleotide sequence ID" value="XM_003050929.1"/>
    </dbReference>
    <dbReference type="PDB" id="6Y0H">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.00 A"/>
        <property type="chains" value="A=30-222"/>
    </dbReference>
    <dbReference type="PDB" id="7ZQ0">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.90 A"/>
        <property type="chains" value="A=34-222"/>
    </dbReference>
    <dbReference type="PDB" id="8AF4">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.51 A"/>
        <property type="chains" value="A=34-222"/>
    </dbReference>
    <dbReference type="PDB" id="8AF5">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.63 A"/>
        <property type="chains" value="A=34-222"/>
    </dbReference>
    <dbReference type="PDB" id="8AF6">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.70 A"/>
        <property type="chains" value="A=34-222"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSL3"/>
    <dbReference type="SMR" id="C7YSL3"/>
    <dbReference type="STRING" id="660122.C7YSL3"/>
    <dbReference type="GeneID" id="9668299"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_106153"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_106153"/>
    <dbReference type="eggNOG" id="ENOG502RXA7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052631_0_0_1"/>
    <dbReference type="InParanoid" id="C7YSL3"/>
    <dbReference type="OMA" id="DYWQNWT"/>
    <dbReference type="OrthoDB" id="2115822at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.180:FF:000001">
        <property type="entry name" value="Endo-1,4-beta-xylanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018208">
        <property type="entry name" value="GH11_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828:SF2">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00911">
        <property type="entry name" value="GLHYDRLASE11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00776">
        <property type="entry name" value="GH11_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="17 18 19" id="KW-0002">3D-structure</keyword>
    <keyword evidence="8 11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0843">Virulence</keyword>
    <keyword evidence="5 11 12" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988498" description="Endo-1,4-beta-xylanase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="GH11" evidence="14">
        <location>
            <begin position="33"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU45262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="6Y0H"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PDB" id="7ZQ0"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="19">
        <source>
            <dbReference type="PDB" id="8AF4"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PDB" id="8AF5"/>
        </source>
    </evidence>
    <sequence length="222" mass="24117" checksum="F1856E1F1BC88412" modified="2009-10-13" version="1">MVSFSYLLAAVSAFTSVLAVPTAETSENPALSKRTQSSTGTHGGYYYSFWTDNPNTVTYTNQNAGQFSVSWSGNQGNFVGGKGWNPGAARTIKYSGTYNPNGNSYLAVYGWTRNPLIEYYIVENFGTYNPSSGATKKGEVTVDGSVYDIYTSTRTNAPSIEGTRTFQQYWSVRRNKRSSGSVNTGAHFNAWSNVGLKLGSHDYQILAVEGYYSSGSATMTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7YU93</accession>
    <name>C7YU93_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE affecting a late Golgi compartment protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_71909</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050476.1">
        <property type="nucleotide sequence ID" value="XM_003050430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YU93"/>
    <dbReference type="FunCoup" id="C7YU93">
        <property type="interactions" value="276"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YU93"/>
    <dbReference type="GeneID" id="9674871"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_71909"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_71909"/>
    <dbReference type="eggNOG" id="KOG3202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061883_0_0_1"/>
    <dbReference type="InParanoid" id="C7YU93"/>
    <dbReference type="OMA" id="EHDPYRF"/>
    <dbReference type="OrthoDB" id="546861at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21444">
        <property type="entry name" value="SNARE_NTD_Tlg1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15851">
        <property type="entry name" value="SNARE_Syntaxin6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.90:FF:000012">
        <property type="entry name" value="SNARE domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000006">
        <property type="entry name" value="Syntaxin 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015260">
        <property type="entry name" value="Syntaxin-6/10/61_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048036">
        <property type="entry name" value="Tlg1p-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09177">
        <property type="entry name" value="STX6_10_61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="147"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU44763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="239" mass="26533" checksum="88A6F030AC4EF47D" modified="2009-10-13" version="1">MMSSTNEEDPFLQVQQDVLTQMASARPLFASYLRIRSLSTNADSPELASARSDLEAALSSLADDLADLVASVQAVESNPAQFGLSAHEVTRRKRLVQEVGGEIDDMHDELAKKVDAVRGGDLPDPNAFAIDGDGDDTYAEFEQQQQMEIMREQDQHLDGVFQTVGNLRRQADDMGRELEEQREMLEVVDEAADRVGGRLQTGMQKLQHVIRANEDRYSSCCIAVLIFVLILLLVLLLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7YV99</accession>
    <name>C7YV99_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_85200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050659.1">
        <property type="nucleotide sequence ID" value="XM_003050613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YV99"/>
    <dbReference type="GeneID" id="9675044"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85200"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85200"/>
    <dbReference type="HOGENOM" id="CLU_690958_0_0_1"/>
    <dbReference type="InParanoid" id="C7YV99"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU44946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="399" mass="44053" checksum="1A9C732FA7AED8BF" modified="2009-10-13" version="1">MASPGDGDSQAPPTSSAGNDLGKRKRNSVHLYFYREPVTAVTGTLASKRRGPPPRRSRVDSDTTTAAQQPPPEPDAPDDSDPGATPVQFDADQEDQESPPALPVQPPDASLPEWLYNFTVKHQDIESLLDVFYQSCYPFARDKSDADSTSVKYPAEVIDDADITETSILQRPDRVSFLRGWNFCTDLYRLLQYLDDTFKTQQQFTRDEPGSEVANLLSLKRAKADPEKPPISYHHTDPQDGSGQQWKPQYPLTLCGCETLRQAVNQVLGEASSAAPDASRPTQNLDDDQHSAWPMPQPHILPSIWNDTTQYPLNPISGPNLPNPTHDTATTSNHPPRDQPLFDDLFHTWSFLIGEPDNLDPADSFAALGMMPRDAYRTSLAPRSTNEANDASGGNMQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVF0</accession>
    <name>C7YVF0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_85252</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050289.1">
        <property type="nucleotide sequence ID" value="XM_003050243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVF0"/>
    <dbReference type="FunCoup" id="C7YVF0">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YVF0"/>
    <dbReference type="GeneID" id="9675074"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85252"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85252"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_15_4_1"/>
    <dbReference type="InParanoid" id="C7YVF0"/>
    <dbReference type="OMA" id="MRYFSPY"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd03046">
        <property type="entry name" value="GST_N_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01150">
        <property type="entry name" value="Main.1:_Beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="86"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU44576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="25087" checksum="474D261CE0CA9125" modified="2009-10-13" version="1">MPIVIHHLHVSQSERIPWLCEELGIPYELKTYSRSPLLAPPEYKALHPMGAAPVIQDGELTLAESCACIEYLSHKYGNGKLFLTPADPAYADFLYWWHWADGTFQPGLGRTMVTQAAKLDVDHPLAVLSRHKFNLTLDALEKRLADNEWLAGREFTVADIMAVFTLTTMRYFTPYSLGEYPNVLSFLQRVGSREAYQKAMKKSDPEMELALGAEPPKSNFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVU6</accession>
    <name>C7YVU6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_56848</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a component of both the DNA-binding general transcription initiation factor complex TFIID and the transcription coactivator SAGA complex. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription. At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B. SAGA interacts with DNA via upstream activating sequences (UASs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TAF10 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049775.1">
        <property type="nucleotide sequence ID" value="XM_003049729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVU6"/>
    <dbReference type="FunCoup" id="C7YVU6">
        <property type="interactions" value="437"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YVU6"/>
    <dbReference type="GeneID" id="9677139"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_56848"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_56848"/>
    <dbReference type="eggNOG" id="KOG3423">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064104_0_1_1"/>
    <dbReference type="InParanoid" id="C7YVU6"/>
    <dbReference type="OMA" id="NNPMGTL"/>
    <dbReference type="OrthoDB" id="154356at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07982">
        <property type="entry name" value="HFD_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TAF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017246">
        <property type="entry name" value="TFIID_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="128"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU44062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="189" mass="19955" checksum="983ED2AEA68E654B" modified="2009-10-13" version="1">MASDAPEKTEQSPAAQNGPADAAPPAPTIPESRLPSRKDTSLREFLNKMDDYAPIIPDAVTHYYMTKAGLPPPPQTDPRLARLLALATQKFIADIAADAYQYSRIRASSNTNNPMGSLGAAAGFPIPGQPTGQPGAKDQNKGAPLGIQRPGYGGGGQGGSQNRTVLTMEDLGMAVGEYGVNVKRSEFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVY5</accession>
    <name>C7YVY5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">37S ribosomal protein S25, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_102941</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the mitochondrial small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS23 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049794.1">
        <property type="nucleotide sequence ID" value="XM_003049748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVY5"/>
    <dbReference type="FunCoup" id="C7YVY5">
        <property type="interactions" value="113"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YVY5"/>
    <dbReference type="GeneID" id="9677159"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102941"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102941"/>
    <dbReference type="eggNOG" id="ENOG502RZQQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081350_0_0_1"/>
    <dbReference type="InParanoid" id="C7YVY5"/>
    <dbReference type="OMA" id="ENWKIWA"/>
    <dbReference type="OrthoDB" id="5542239at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23701">
        <property type="entry name" value="At1g26750"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059242">
        <property type="entry name" value="mS23_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016939">
        <property type="entry name" value="Ribosomal_mS23_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13741">
        <property type="entry name" value="MRP-S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029764">
        <property type="entry name" value="RSM25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="206"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR029764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU44081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="239" mass="28005" checksum="DF2F359A859E40F7" modified="2009-10-13" version="1">MGGRQIRPARVFQTVTEELNHNLLGQKSIATPPWYNIMQTIPPSETLVRPIPTRHRAPNPRATKPKNIFRPQRIKYLEDGLRTTFYKDHPWELARPRIIMELDGKDYQHCDWSKGLKQPSIPLSGECVVQRQMWLMENENMTERKAYDVTRREFYRLRQAEEIEKRVAVEEARHVGAYFGKTRIDVSHGLEDREFENWKLWAGKETERTEARRNSEIESFGLEEEEGAAGGEETDKVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXF8</accession>
    <name>C7YXF8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_82514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049295.1">
        <property type="nucleotide sequence ID" value="XM_003049249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXF8"/>
    <dbReference type="GeneID" id="9666276"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82514"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82514"/>
    <dbReference type="eggNOG" id="ENOG502QUHS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047583_0_0_1"/>
    <dbReference type="InParanoid" id="C7YXF8"/>
    <dbReference type="OMA" id="LWMHVPA"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047975">
        <property type="entry name" value="Heme_bind_FMP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040572">
        <property type="entry name" value="heme_bind_FMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU43582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="436" mass="46848" checksum="F622B4A26255D3D7" modified="2009-10-13" version="1">MSPPLPVAPSVSIEIPQNFAFGPTVLDPIEQPVEDGTNGTHGDSKEHPSHLVTGAAAVPVTSLDVLANFKGTFRGFGFNTIFRPDNKITPTHFPVKPTDTNDDNVLQLNLTSETMTFGNELGNVPNRGLGEQADIMLNGVPYTQTILDAMPSDVLSPCKPPVIHFEPGLWMRVPEVATMPDLAASFNRMASIPHGTTINAQCFGPAVTHKGPPVIPSVGITPVFLPTGKETPFASQTASDKASRRLPQDLTPFEKDGTITQEILNDPNTVLRNANKGKHIVEHTTFTVTTASQPPNLGGGTSNIGFNIGADDGAVFPATPKERSGNANATKMTAQYWISKVRAEIRLLPCMEKGDVVSPVSHGPRDAVPQFVIDRHHVVTAPKTITVEYTQIQYSQFVALDFNGLGWPHVSVATLAPTKHFNGPKLKHVVVGKKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXK4</accession>
    <name>C7YXK4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_45013</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049071.1">
        <property type="nucleotide sequence ID" value="XM_003049025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXK4"/>
    <dbReference type="GeneID" id="9666372"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45013"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45013"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="C7YXK4"/>
    <dbReference type="OMA" id="CIRKIDW"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000364">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF54">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="40"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU43358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="497" mass="54724" checksum="AE511FF7501C0E3F" modified="2009-10-13" version="1">MLEDQKTPRHSHLSAEDQAWLDSFPDDRKKAVVRKIDFRLVPLLAILYLFSFIDRANIGNAKIEGLEEDLKITPSQYNIALSVFFVPYVVLEVPSNYLLTKFKRPSVYIGGIIVAWGIVMTLMGIVQNFSGLIASRYMLGVAEAGFFPGAVYIISQWYMPNEIQTRIAIFYSASALAGALSGLLAFGIARMDGVGNLEGWRWIFLLEGIATVMAGIACFFCLIDNAESSAWLDDDEKRFLSLRRIAVMGDQSAKHAETISKRAKWSVLKSVLCDWQVYFQSIIYISATMPNYGLKFTMPQIIKNMGYTSANAQLLTIPPYCVGAISAFLSAIFADRLKWRMPFIVGAQTIVLIAFSILFAKAADIKDNIGLCYFGVVLACVGLYPITPGANAWTVNNLAGRTKAAMGIAYMIAIGNSGGIPGSYIYIQSEAPKYPTGFGVSLAAAGAGILSAVTLEVTYRSINKRRSKMSVEEVYGKYSAEELEAMGDRSPLFRYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7YY95</accession>
    <name>C7YY95_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Four-carbon acid sugar kinase nucleotide binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_95400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the four-carbon acid sugar kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048861.1">
        <property type="nucleotide sequence ID" value="XM_003048815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YY95"/>
    <dbReference type="STRING" id="660122.C7YY95"/>
    <dbReference type="GeneID" id="9667806"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95400"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95400"/>
    <dbReference type="eggNOG" id="KOG0409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044742_0_0_1"/>
    <dbReference type="InParanoid" id="C7YY95"/>
    <dbReference type="OMA" id="HFLVPAF"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.20">
        <property type="entry name" value="Four-carbon acid sugar kinase, nucleotide binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10840">
        <property type="entry name" value="Putative sugar-binding, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010737">
        <property type="entry name" value="4-carb_acid_sugar_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037051">
        <property type="entry name" value="4-carb_acid_sugar_kinase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031475">
        <property type="entry name" value="NBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042213">
        <property type="entry name" value="NBD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17042">
        <property type="entry name" value="NBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07005">
        <property type="entry name" value="SBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142764">
        <property type="entry name" value="YgbK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Four-carbon acid sugar kinase N-terminal" evidence="7">
        <location>
            <begin position="41"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Four-carbon acid sugar kinase nucleotide binding" evidence="8">
        <location>
            <begin position="305"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU43148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="51609" checksum="A37D17F960E60435" modified="2009-10-13" version="1">MTGQTVLNKDATLAALPPVVATNLRSQTRQELTSSPKTPILVILDDDPTGTQTCHDINILTVWDVATLAEEFKQTNQGSGFFILTNSRALHPQQAKELITDICGNLHTASKETGTSFEVVLRSDSTLRGHFPLEAEAAEHVLGAADAWILCPFFLQGGRYTINDIHYVQEGDHLVPAAQTPFAKDATFGYKSSNLRDYVVEKTKGAIPKERVTSISLDIIRTGGVDAVLGQLLQEAKGPRPVIVINAAADEDIDVVVAALIKASDSGKRFLFRTGAAFVSARLGIPSIPPISASQLHLSGDVGGLTIAGSYVPKTTAQLESLRQLAGKELTSIVLDVHKLLQSPEGASKEVQDALETAEAEIKRGQDVLVMTSRELVVGDDEAKSLDIGSTVARALVSFLEKLDQKPRYIIAKGGITSSDMATKGLRMKRALIVGQAAPGVPLWRCDEAESKWPGLPFVVFPGNVGTDETLYRVVEGWRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZL2</accession>
    <name>C7YZL2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_95762</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048338.1">
        <property type="nucleotide sequence ID" value="XM_003048292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZL2"/>
    <dbReference type="FunCoup" id="C7YZL2">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YZL2"/>
    <dbReference type="GeneID" id="9667415"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95762"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95762"/>
    <dbReference type="eggNOG" id="KOG1305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009020_4_1_1"/>
    <dbReference type="InParanoid" id="C7YZL2"/>
    <dbReference type="OMA" id="FLFFGSQ"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF458">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="150"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU42625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="553" mass="58720" checksum="901F951BCF7ABE9E" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0N9</accession>
    <name>C7Z0N9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_40180</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047948.1">
        <property type="nucleotide sequence ID" value="XM_003047902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0N9"/>
    <dbReference type="GeneID" id="9671933"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_40180"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_40180"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="InParanoid" id="C7Z0N9"/>
    <dbReference type="OMA" id="ILFQFPV"/>
    <dbReference type="OrthoDB" id="1932925at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF55">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="48"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU42235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="505" mass="55652" checksum="5AD747D3BBB3F11D" modified="2009-10-13" version="1">MGAHETQQTDSEAAVGNKDEAIAIVGEEQHAIDPVVAARAVRKIDLFLIPAMIVGYGLVYYDKAILGSAVLFGMTADLDLTIVDASTTPPTVDTRRLSWATSLFYFGMLAGLYPMTFALQRFNIGRVLGGVVVVWSAICMLTAAVTSHQGLYVQRFFLGFVESIIPTGFMCIVSGYYTQTEQSLRQSWWFSSTGIFTIIGGALNYGFAQITGGGLKRWQYIYLLAGSLTFLFGLFCFVMPNSPVSAWFLTKEERFAAVERLRHGQTGVRCTTFKTSQLKEAVLDVKIWLVALMMASAYTVNGAVSGFGPLIVSTFGWSTLHSILFQFPLGGLCFIVILLTGWLGTKFNNIRIFMLIFTCLPVITGCAIIWKSEWSYRAAAPVVGYSITGFFGGTVSLIITIGMSNVAGHTKKSFMAATIFVAYCVGNIVGPQLVWSQTKSEHYPALWLGLIICYIICILASTALYFVLRNENKKRDAVPGDEAERAKLAFQDLTDKENPYFRYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1H0</accession>
    <name>C7Z1H0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_86149</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU42004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047717.1">
        <property type="nucleotide sequence ID" value="XM_003047671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1H0"/>
    <dbReference type="STRING" id="660122.C7Z1H0"/>
    <dbReference type="GeneID" id="9671502"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86149"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86149"/>
    <dbReference type="eggNOG" id="KOG4730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_9_0_1"/>
    <dbReference type="InParanoid" id="C7Z1H0"/>
    <dbReference type="OMA" id="FFPHGHA"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="35"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU42004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="483" mass="53801" checksum="570EE0BC005AFF3F" modified="2009-10-13" version="1">MTSSASPDVILPTVLQRGTSDYENSRERYFNKEETDRFPIEIHAVQSVEDVYKALQRAQELGVAVGVRSGGHLPSKPSLINNGILIDVSHLNREIKYDSQTGQVSFGPAVRVYEAWKSTDALGRFFPFGHAPDVALGGFCLAGGQGFFMRGWGATVTDWIIKLEIVVPDGRVLIASKTENSDLFWAARGAGQAFFGVVTRIWSRTIPKKKHYGRAYTFSGKDNYEAFLSFAFERNNQMPKSFTETAACTLHPELFEPDSPDESVPSTSPLLLLVNISAYADTLSEAESMLSVWDQVPENLKGCLIESKPVAEVDWEEFFKLQHLLNPQTPGQKWGINSILNDPAIPRDKLIEAIKPAMCNLPTRSSYGCIYMADTLDVDEADAVLSIPQQYYISTFSGWKDVSLQTKVRQVMQHSYKQAESVACGMYVADFDQSPGALHSSSIPVWSKSACAKFMRIREKWDPKGLFIGYKAFVLTPKEDTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1R4</accession>
    <name>C7Z1R4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA primase large subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_50539</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU41869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047582.1">
        <property type="nucleotide sequence ID" value="XM_003047536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1R4"/>
    <dbReference type="FunCoup" id="C7Z1R4">
        <property type="interactions" value="925"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z1R4"/>
    <dbReference type="GeneID" id="9671545"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_50539"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_50539"/>
    <dbReference type="eggNOG" id="KOG2267">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026253_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z1R4"/>
    <dbReference type="OMA" id="RINYKPW"/>
    <dbReference type="OrthoDB" id="421393at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07322">
        <property type="entry name" value="PriL_PriS_Eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.80:FF:000003">
        <property type="entry name" value="DNA primase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058560">
        <property type="entry name" value="DNA_primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016558">
        <property type="entry name" value="DNA_primase_lsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537:SF3">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26466">
        <property type="entry name" value="DNA_primase_lrg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009449">
        <property type="entry name" value="DNA_primase_large_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA primase large subunit C-terminal" evidence="11">
        <location>
            <begin position="306"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR009449-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU41869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="508" mass="58771" checksum="F4B6CF98CE26E15D" modified="2009-10-13" version="1">MLRQDFNRIDPKRRNVVDYRKKQFATPQYKDLDYPHRLNFYTDPPTADITLEQFEQWAIDRLRGKFFTSEAVLAELEACSFRNKSPAETATHMKPILKKYLNLEANSSGSTKIFAQRQKDHYSHFILRLAFASTEDLRRRFTRVETMLFRLRLNDDDLAERSAFVKTLGLDWCEDVTEDDRREYAAELAAFSSGRKGDAEDDSWFKVDWERVPELIESRRVFLKAGKAFVPGREQTGMVIGEFSSRLERQLELTARALPRLDEDDRLTPILNHLSKNFITPDSAYSSNTAAVPGAHISAANIDNLSQHFPACMSHLHRSLRRDAHLKHYGRLQYGLFLKGIGLNLEESLMFWRSSFHKITDDTFNKDYRYNVRHIYGDVGGDSNRRGGGYSPFSCQKILTEHPPGPGEAHGCPYRHFSLENLTALVQSMGVNDRSVIQGIKEDKDKQKYHMACNRVFEYLHKAEMKKAKDEGVMTQNQLETMVHPNEYFKRSFLLKNLGKETDVNMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z298</accession>
    <name>C7Z298_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BAG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_101954</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU41964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047677.1">
        <property type="nucleotide sequence ID" value="XM_003047631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z298"/>
    <dbReference type="STRING" id="660122.C7Z298"/>
    <dbReference type="GeneID" id="9671634"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101954"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101954"/>
    <dbReference type="eggNOG" id="ENOG502S9SN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032998_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z298"/>
    <dbReference type="OMA" id="MSWRNPL"/>
    <dbReference type="OrthoDB" id="417450at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039690">
        <property type="entry name" value="SNRNP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14942">
        <property type="entry name" value="U11/U12 SMALL NUCLEAR RIBONUCLEOPROTEIN 25 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14942:SF0">
        <property type="entry name" value="U11_U12 SMALL NUCLEAR RIBONUCLEOPROTEIN 25 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51035">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="89"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="BAG" evidence="4">
        <location>
            <begin position="239"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU41964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="34112" checksum="ABE0500B96E9DB9F" modified="2009-10-13" version="1">MSRYGWSISREQLSPYGSVPGDVPAVTDDDFSYITSQDLDDVTEAQYYPRSHSAAPPAPEDDVLLIKNRGVTYPAHFPAYAIGDGKLRVIDVKDRVGLMMELPVRGTSRIKLLYKGKQLKDPLAPVRDYGVKNNSELMAVIPEIEDISSPSDEEMVIVDAPREDRKTRRRKKKRDKKKGITSDSDSMSASNPRDSTSTFDQPRSPPAPPVSSGATSGPMKALDDLAVEFQIKWLPLCTDYIEAPPSDPKKREEDHRKVSESIMQHIMLKLDCIDSEGIAEVRARRKELVQQVQKTLKQLDVAKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z2E9</accession>
    <name>C7Z2E9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Expressed protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_102146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047180.1">
        <property type="nucleotide sequence ID" value="XM_003047134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z2E9"/>
    <dbReference type="GeneID" id="9676353"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102146"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102146"/>
    <dbReference type="eggNOG" id="ENOG502RMIW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1219979_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z2E9"/>
    <dbReference type="OrthoDB" id="5028429at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022190">
        <property type="entry name" value="DUF3716"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12511">
        <property type="entry name" value="DUF3716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU41467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="227" mass="25157" checksum="63521D0DF12CFD4A" modified="2009-10-13" version="1">MSSLPEHPKPFPRGGAEEIPGYPSARARYVPATIFGVETSSFDYNAPQPAENPDLTVWVLMHAINGCSSKVIKILSERRPVRQLELRTKIDSRSLKPVPYNINLRNSQNCDAMIRHLYGEELEEEDQCAKCKDSKGALIGCVVCPDIAANCANCDWNRSGGQCSLGGAASARRRAKRRPAPESESEDQDEEDTNNLWEVFNDMDPATLTRLSVVLSEAAKRTGHSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z2W1</accession>
    <name>C7Z2W1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mandelate racemase/muconate lactonizing enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_64742</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047263.1">
        <property type="nucleotide sequence ID" value="XM_003047217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z2W1"/>
    <dbReference type="STRING" id="660122.C7Z2W1"/>
    <dbReference type="GeneID" id="9676180"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_64742"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_64742"/>
    <dbReference type="eggNOG" id="ENOG502QRWW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030273_3_2_1"/>
    <dbReference type="InParanoid" id="C7Z2W1"/>
    <dbReference type="OMA" id="EYMRHTE"/>
    <dbReference type="OrthoDB" id="2579025at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008869">
        <property type="term" value="F:galactonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034194">
        <property type="term" value="P:D-galactonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03325">
        <property type="entry name" value="D-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023592">
        <property type="entry name" value="Galactonate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010624">
        <property type="entry name" value="PRK14017.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080:SF2">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00003">
        <property type="entry name" value="D-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00908">
        <property type="entry name" value="MR_MLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="5">
        <location>
            <begin position="126"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU41550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="381" mass="42122" checksum="74E49BA4A1603BE2" modified="2009-10-13" version="1">MGKIASIEYFRVPPRWLFVKITDDAGNVGWGEASLEGHTQAVEGCLDAWISQYTGMEADEIEQIWQKSWRLGFYRGGPVFMSALAGIDIALWDLKARKLNLPIYQLLGGKVRDKIKVYAWIGGDRPSDVEAEALSRRAQGFTAVKMNGTEDLGWLDSPSALDACVERVKTVKALGMDAGVDFHGRVHKPMARQLAALLEPHRPMFIEEPLLSEHIEGIKAFSQTVTCPIALGERLHSRWDVKPFLEAACVDILQPDICHVGGISELRRIAAMAETYDVAIAPHCPLGPIALAANIQVDATTPNFAIQEMSLGIHYNTGGHDLLSYIKNPEIWNIENGYIDLMKGPGLGIEVDEEKIRELSKNAVPWVSPGFVGPGGEWREW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z395</accession>
    <name>C7Z395_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_87871</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047330.1">
        <property type="nucleotide sequence ID" value="XM_003047284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z395"/>
    <dbReference type="GeneID" id="9676246"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87871"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87871"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_6_3_1"/>
    <dbReference type="InParanoid" id="C7Z395"/>
    <dbReference type="OMA" id="PKPMDEQ"/>
    <dbReference type="OrthoDB" id="1663137at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04733">
        <property type="entry name" value="OYE_like_2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051799">
        <property type="entry name" value="NADH_flavin_oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656:SF5">
        <property type="entry name" value="NADH:FLAVIN OXIDOREDUCTASE_NADH OXIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="5">
        <location>
            <begin position="18"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU41617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="437" mass="48230" checksum="A8610A94172311B6" modified="2009-10-13" version="1">MTPRRYPASPTDPSPLGKPLTFEFSGKAAKNRLLKAAMTERLSTWHPNNLEERGGEGGFGVILTGHIMIAYDQLEAAGNSVVSRDAPFFGERFEAFKEMASVTKQHGSLAVAQISHPGRQVGNLIQKNPISASDVQLEVEVMGMHFNKPKAMEENDFKNVVEGFAHAAEYLYKAGFDGIQLHGAHGYLLAQFLSPTTNKRRDKYGGSIENRSRLIFEIADAIRTRVTDPSFIIGIKVNSVEFQEGGFSTEDCEILCRNLEQHGFDFLELSGGTYQSLGFTYYRESSKKREAFFLDFADKIIPELSKTKAYVTGGLRTVKAMVDALDTVHGVGLGRPATHEFDLAAKILSGEANSAIDYLLDEQNFGVTNIASGAQIRLVGKDKQPLDLSREDHLKAFQDSMTQWGQGMTQNKDNFKFGFVDIQGVRLEPYGASYASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z3A0</accession>
    <name>C7Z3A0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_87876</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047333.1">
        <property type="nucleotide sequence ID" value="XM_003047287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z3A0"/>
    <dbReference type="GeneID" id="9675943"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87876"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87876"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_11_0_1"/>
    <dbReference type="InParanoid" id="C7Z3A0"/>
    <dbReference type="OMA" id="ANEGFTH"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF10">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="57"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU41620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="543" mass="59905" checksum="56894B76B4D1A226" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4V9</accession>
    <name>C7Z4V9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_76654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046704.1">
        <property type="nucleotide sequence ID" value="XM_003046658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4V9"/>
    <dbReference type="GeneID" id="9678509"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76654"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76654"/>
    <dbReference type="eggNOG" id="ENOG502R9N5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_539721_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z4V9"/>
    <dbReference type="OMA" id="TINYMAW"/>
    <dbReference type="OrthoDB" id="5102964at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU40991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="545" mass="63486" checksum="E76D5D9F01681781" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z5I5</accession>
    <name>C7Z5I5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">hydroxyacid-oxoacid transhydrogenase</fullName>
            <ecNumber evidence="4">1.1.99.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_58609</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate</text>
            <dbReference type="Rhea" id="RHEA:23048"/>
            <dbReference type="ChEBI" id="CHEBI:11047"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + succinate semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:24734"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16724"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.24" evidence="4"/>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU41108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046821.1">
        <property type="nucleotide sequence ID" value="XM_003046775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z5I5"/>
    <dbReference type="STRING" id="660122.C7Z5I5"/>
    <dbReference type="GeneID" id="9678626"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_58609"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_58609"/>
    <dbReference type="eggNOG" id="KOG3857">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007207_0_7_1"/>
    <dbReference type="InParanoid" id="C7Z5I5"/>
    <dbReference type="OMA" id="NLMGAGC"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047988">
        <property type="term" value="F:hydroxyacid-oxoacid transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08190">
        <property type="entry name" value="HOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000009">
        <property type="entry name" value="Fe-containing alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000003">
        <property type="entry name" value="Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042157">
        <property type="entry name" value="HOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF83">
        <property type="entry name" value="HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="9">
        <location>
            <begin position="75"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="10">
        <location>
            <begin position="297"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU41108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="495" mass="53269" checksum="EC89B1FB3DBE0B12" modified="2009-10-13" version="1">MVPAVRAIPNAAKRATNLLRTVQFTHPPSCPCHSNPGYHQSPPVLTPSRHAHQRKYATPTTHPGQKEYAFEMAASSIRFGPGVTQEVGMDLKNLGAKRVCVVTDENVDKLDAMRQVREALTREGVPFEVYSKVRIEPKDSSIKDAIAWARPYEPDAFLAVGGGSVIDTAKLMNLYTAYPDADFLDFVNAPLGKGRPVDKPLKPLIAVPTTAGTGSETTGTAIFDLVSKRAKTGVAHRNLKPTLGICDPLNTRTMPAAVKAASGLDVLCHSLESWTAIPYNERTPRPTNPILRPAYQGANPISDVFSFHALRATVKYLPRSVRDPDDLEAQSEMLLASTLAGVGFGNAGVHLCHGMSYPISGQNPGYKHAGYQIDSPIIPHGVSVAVSAPAVFRFTAASNPDRHLAAAEAFGVDITNVKRESAGEVLAEAITKFLAELGDQPKGLKELGFGTEHIEALVEGTIPQARVLSLAPGLSSQLEAEKDQLRRLFENAMTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z798</accession>
    <name>C7Z798_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Leucine carboxyl methyltransferase 1</fullName>
            <ecNumber evidence="3 8">2.1.1.233</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_34349</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:48544"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="2.1.1.233"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.233" evidence="3 8"/>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046546.1">
        <property type="nucleotide sequence ID" value="XM_003046500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z798"/>
    <dbReference type="FunCoup" id="C7Z798">
        <property type="interactions" value="557"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z798"/>
    <dbReference type="GeneID" id="9668256"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_34349"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_34349"/>
    <dbReference type="eggNOG" id="KOG2918">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031312_1_1_1"/>
    <dbReference type="InParanoid" id="C7Z798"/>
    <dbReference type="OMA" id="IIYEPIR"/>
    <dbReference type="OrthoDB" id="203237at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018423">
        <property type="term" value="F:protein C-terminal leucine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016651">
        <property type="entry name" value="LCMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600:SF21">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016305">
        <property type="entry name" value="LCM_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="193"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR016305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR016305-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU40833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="374" mass="41065" checksum="03E9502F801EB86C" modified="2009-10-13" version="1">MSASEIPNLLSSLRSARGGRGRGRGRGGHHGPSSITHDATIQGTDTDASVSRLSAVDLGYLDDPYAQFFVQSADGPPARRLPIINRGTYTRTISLDTLVDSFLNGDESGSLPKQIVSLGAGTDTRPFRLFASKSRPGLVYHEIDFEVVASRKLRTVQATPPLRNILTNISNDTKSTWSSRPASGGEYYCHGQDLRNLAPRKVPNPDEESSSQPKEQPGVTLPGLRSNIPTLLISECCLCYLNVTEASNVISFFSSQIPSLATIIYEPTHPDDAFGRMMVSNLAARRIQMPTLDKYPTPEAQRTRMTEAGFETVHHMTIEKIWETWVSPEEKQRVDYLEGLDEVEEWKLLAAHYIVVWASKGNGFGSWESVGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7B4</accession>
    <name>C7Z7B4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_32777</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045989.1">
        <property type="nucleotide sequence ID" value="XM_003045943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7B4"/>
    <dbReference type="GeneID" id="9668973"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_32777"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_32777"/>
    <dbReference type="eggNOG" id="ENOG502SMXQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040076_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z7B4"/>
    <dbReference type="OMA" id="GPMFADD"/>
    <dbReference type="OrthoDB" id="5343688at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="190"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU40276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="326" mass="35876" checksum="1FDE98F808C39590" modified="2009-10-13" version="1">MEGPHHIAIRELDLRTCHPSTMADRVGAVPVLKTSAAFFTFLRANLVLHSAMTSATNSPQLGPSVPFSSYVPPSPSPLAAHGPFCGFDDDDDIEPLSLEVLDKPQDKIEGLRLVADSIAQMRQRASLNLVFHPLCLAGLSTTLAAIYHLGGVSRLDPGLSMTISCGVIMSYLMGIRYLASGYISLAERLRWNWLRADDGEEDTLLAARINDDIVGTLVLRLEPNPTSGHRRRRSLSLRGGKGVIRAWTTNLHYRGKGVGKDLLHEAVRMTKERCGKDAEIGFAQEHANSAMLLPGIFNAPFRRDEVRATKALDGVLADWDMFKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7F2</accession>
    <name>C7Z7F2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_32437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046005.1">
        <property type="nucleotide sequence ID" value="XM_003045959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7F2"/>
    <dbReference type="STRING" id="660122.C7Z7F2"/>
    <dbReference type="GeneID" id="9668989"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_32437"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_32437"/>
    <dbReference type="eggNOG" id="ENOG502RXZ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063930_3_0_1"/>
    <dbReference type="InParanoid" id="C7Z7F2"/>
    <dbReference type="OMA" id="VMNVMIR"/>
    <dbReference type="OrthoDB" id="544277at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="164"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU40292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="261" mass="29715" checksum="B21C1F9EE7FC56AB" modified="2009-10-13" version="1">MEGTTTTKSISHNLSGASALAKWRRRSLVPPSWEDSIRFVSVNESAEAGRSLAHAFATDAMSQYVLDGDDMADYSDEQKWKLHVDHMTYMVAAHCYKGVVTAIGSDYDAVALWLPPGQQMDDWWTSLRSGMWRLYYQLSAEGRRRYYDEMLPVLNQTKEEVMGERDKDCYYLVYIGTKPAAQGKGYAGKLIRDMADAENRPMYLEASTKRNSEYYAKFGFKVKRPVVFENGPEPITMYIMVREPQTPRQSCGPAVMATVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8D1</accession>
    <name>C7Z8D1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_106084</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045689.1">
        <property type="nucleotide sequence ID" value="XM_003045643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8D1"/>
    <dbReference type="STRING" id="660122.C7Z8D1"/>
    <dbReference type="GeneID" id="9672589"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_106084"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_106084"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079424_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z8D1"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF333">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitinase II/V-like catalytic" evidence="3">
        <location>
            <begin position="62"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU39976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="305" mass="34512" checksum="37C4FE3168B2DD20" modified="2009-10-13" version="1">MAKDIRVLAILSSNAIRTTRARVMHAIPICSKDNYVAGCDAKAEYDPSGFRSSFANYTKCPLNVYYSKYSYYGTTKDFCGKKTMNRLSCSSKSSPIRRVFRPSNIPDSIYTHINFAFASINPKTFQIILISSNDPALYRELIRKKEINPNLKANQRTFIKSLILFIATYGFNEDEKRIITIFLTHFNLEKISKYIDYFNFIIYNFHVPLLTISSQIKDAFDLLWRNKIDPNQVNIGLAFYAYTFSISNPGCMSPGCLFDAGGSAEPYTNAVGVMSNPEIMGKLVRKSQGELDKTAASKILKFGHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8Y8</accession>
    <name>C7Z8Y8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_42834</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044771.1">
        <property type="nucleotide sequence ID" value="XM_003044725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8Y8"/>
    <dbReference type="STRING" id="660122.C7Z8Y8"/>
    <dbReference type="GeneID" id="9673681"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_42834"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_42834"/>
    <dbReference type="eggNOG" id="ENOG502RHJM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038732_9_0_1"/>
    <dbReference type="InParanoid" id="C7Z8Y8"/>
    <dbReference type="OMA" id="FGWPEEY"/>
    <dbReference type="OrthoDB" id="2349068at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF34">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU39058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="364" mass="38822" checksum="97ED7751B0CB14D9" modified="2009-10-13" version="1">MSVTRAALTTSRARLTHLFPWVTSPFIVGAPMRVMSGPDLALAISKAGGLGFIGPGAKPEDTANDLITVRELLKNAPPNTLPQSFPSQGVLPVGVGFQLWNGDLDSAVQAVQQHRPCVAWLFAPRRGQEELDEWATRLREASPGIQIWTQIGTVKESIEAAKSDNRPDVLVIQGAEAGGHGRANDGLGIMALFPEIADKLKDSGITLIAAGGIADGRGVAAALALGAAGAAMGTRFLAATETRINKGYQREVVRASDGAQCTTRTMLYNHLRGTMGWPEQYSPRGIVNQSWHDQQAGVAFDELKLRHDEAAKTGEKGWGPEGRLATYAGAAVGLVHEVEDAGLLVQRIQCETRDIVRRVAEEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z985</accession>
    <name>C7Z985_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_81592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044725.1">
        <property type="nucleotide sequence ID" value="XM_003044679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z985"/>
    <dbReference type="GeneID" id="9673227"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_81592"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_81592"/>
    <dbReference type="eggNOG" id="ENOG502SGW6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_357902_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z985"/>
    <dbReference type="OMA" id="MEVRTIS"/>
    <dbReference type="OrthoDB" id="2571985at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="756" mass="85846" checksum="406C08C2D8D76CC6" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9G7</accession>
    <name>C7Z9G7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_100921</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044807.1">
        <property type="nucleotide sequence ID" value="XM_003044761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9G7"/>
    <dbReference type="FunCoup" id="C7Z9G7">
        <property type="interactions" value="289"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z9G7"/>
    <dbReference type="GeneID" id="9673792"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100921"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100921"/>
    <dbReference type="eggNOG" id="ENOG502QQTI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007201_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z9G7"/>
    <dbReference type="OMA" id="DWHPRNL"/>
    <dbReference type="OrthoDB" id="2262349at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000012">
        <property type="entry name" value="C6 transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="50"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="555"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="9"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="568"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU39094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1003" mass="111954" checksum="ABC469B558487E7F" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZA83</accession>
    <name>C7ZA83_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alcohol dehydrogenase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_43302</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044942.1">
        <property type="nucleotide sequence ID" value="XM_003044896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZA83"/>
    <dbReference type="STRING" id="660122.C7ZA83"/>
    <dbReference type="GeneID" id="9672124"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_43302"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_43302"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_3_1"/>
    <dbReference type="InParanoid" id="C7ZA83"/>
    <dbReference type="OMA" id="FMTPGDI"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08283">
        <property type="entry name" value="FDH_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF1">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="5">
        <location>
            <begin position="63"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU39229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="452" mass="49682" checksum="E8E6C777B71B5A17" modified="2009-10-13" version="1">MASQAAYQAEKVIGHGDNAVTQQDVTSYEGETGKPGETMKALAWMGKNKVKMVDAPRPKILEDRDVILKVTGSTVCGSDLHLLHGTVIQLNEGDILGHEFCGVADEIGPGVTGIEVGKRYVASFQIACGECFFCKQKLSSQCEKTNSNTAERAMYGGRTAGMFGYSHFTGGFAGGQAEYVRVPLGDVNLLEIPTDVPDEKALYLSDVLATSYNAVKDTAVYPEDEVAIFGAGPIGQMAGIFAIREGASKVIFIDTEPRLSFIKDNWPPKHKDQLELVDYKHLSHGVTNKETVVSRLKDLCGGRGPDVAIECAAGEYAKGWMHWLEMSLGIETDTSEIVNEMIEGVRNYGRCGVTGVYVGYTNHFNIGSLMERGIRLIGNGQAPVHKYWKELLAMIQSGDLDPTQMISHRVRLEDLDKVYYKFEAREDAMQKVFVETKFSFPRSIESPDLTTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAM7</accession>
    <name>C7ZAM7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_94735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045418.1">
        <property type="nucleotide sequence ID" value="XM_003045372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAM7"/>
    <dbReference type="STRING" id="660122.C7ZAM7"/>
    <dbReference type="GeneID" id="9672373"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94735"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94735"/>
    <dbReference type="eggNOG" id="KOG2742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028866_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZAM7"/>
    <dbReference type="OMA" id="GHYSERI"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF7">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G10190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="7"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="379" mass="41974" checksum="0E9C8E7878EE43BD" modified="2009-10-13" version="1">MSPKVLHVGIIGGGDVAQIVHLPTFLFLSDLYKVVTVCDVSQKTANHCATKFGVPRATTKPAEIFDDASIDVVVVLTSDEYHAPYTIAALRAGKHVMVEKPITLSLQAAQEIIETEGSAPNGARVFVGYMRRYAPSLQAFKREVASIGSIKYARVRDIIGPNAYFIGQSGTEPKKYHDDIPLEASQDRSARLSALLEQAWGTPFGDLSPEQMDYCCLLANLGSHGLSLMREVLGGLPERVLASTDNARWYTAMFEYKNRTDAQDRFTCLYETGIDQVPRFDSQVAVFGETKSVSIRYDTPFVKGLGITVEIDELNEHGEKCHRTLQTSYEDAYTAELRDWYECVVSGKEIKTTAKDALEDLKLFKMMMEKSATFVPSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZB21</accession>
    <name>C7ZB21_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatidylinositol-specific phospholipase C X domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_45692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044431.1">
        <property type="nucleotide sequence ID" value="XM_003044385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZB21"/>
    <dbReference type="GeneID" id="9670740"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45692"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45692"/>
    <dbReference type="eggNOG" id="ENOG502QWJU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031469_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZB21"/>
    <dbReference type="OMA" id="GKWATGH"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08621">
        <property type="entry name" value="PI-PLCXDc_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF143">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C X DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988962" description="Phosphatidylinositol-specific phospholipase C X domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU38718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="56435" checksum="C49D2C1F5AF800A2" modified="2009-10-13" version="1">MLSRLLLGAAALASFVAAAPAIEPVTHAVKIRSDNEGSSVEVWEDDESGGLERRGKKGSYFLLVNATPWKMTLAGRSSYQMNVWEFPEIIEPGTSNRIYIEGKGHIDDGGEVSYRFEALLGHPDFEFRYSGKLGENRVPGAGIRFGSLETVNNKPGTFHKLEWRKDNNIPFIIASSEENPENPSIQPWLVSSNPPQDWMHATYPRISCLKLRELAIPGTHDSGMSQFNGGGSGFGAPLNSKTQELSVAGQLEFGARWFDIRPSKTGGRWATGHYSFAAGNWHGGNGEYLDDIIDGINRFTENNKELIILNVAQGLNSDNFKGDKDAKISQAEWEDVMRQLERINHRVENRGGEEDISQLRVSDFIQDRAAVIIIVDAELYKTQDRVDLSAFADKGFFRRNQLPLYDRYADENNQNKMIEDQLNKLREQRQSADSTMFLLSWTLTQAGLNVVENGKGANRALIEKLWLTMSSSTYPNIINIDAYPSNRDFAALSMAINYHFAPRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZB96</accession>
    <name>C7ZB96_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxy-cis,cis-muconate cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_95122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044491.1">
        <property type="nucleotide sequence ID" value="XM_003044445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZB96"/>
    <dbReference type="GeneID" id="9670793"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95122"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95122"/>
    <dbReference type="eggNOG" id="ENOG502RZKQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045869_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZB96"/>
    <dbReference type="OMA" id="GSKWIAI"/>
    <dbReference type="OrthoDB" id="1715191at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF4">
        <property type="entry name" value="CYCLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="38352" checksum="2AB8617020E00A1D" modified="2009-10-13" version="1">MILTRTHHLFSGFFSGSTIAEIEFDDTTSSLTLVKSISSEASGSKWITLDARKKNLYVATTSAFQSYKLTEDLNLAYESSVNLSSSCNNANFVTALSKAPYTVFGTPYGSGCPTLAISTDSSGTLEATVANASYLDSSGVHGTALSLKNAFLYSADDMGNAVWVHSYDKVTGVVREVQYLAAASGSNPRHLTVHPNGKWVYVVYEEANAIAAYERDTTTGKLEFHHETYSLLPSGFMNSSSYWADEVLLSIPADADSPKYLLAATRSRTTGTPGYVSAFSLDAKSGDIKKQLFLQPTTGSGGSANAVSPAPFSEDYFAITDSGENFVQVWRIEKKKASVIAHLDLENGPANVVWYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBL2</accession>
    <name>C7ZBL2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_88466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698915">
        <property type="protein sequence ID" value="EEU38591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044304.1">
        <property type="nucleotide sequence ID" value="XM_003044258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBL2"/>
    <dbReference type="GeneID" id="9670627"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88466"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88466"/>
    <dbReference type="HOGENOM" id="CLU_1384479_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZBL2"/>
    <dbReference type="OrthoDB" id="3599942at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU38591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="197" mass="22119" checksum="810451FD722EC254" modified="2009-10-13" version="1">MSAEPVTQDDGIAENNDIVHKIASTSNLRELIQAVPSSYRAKLKDYLVGEYHIYRLHAKVQRTIWAYERHANEGSLPFCVSNVLNEPTLEFTSEFLRSTDGYAALEAFERQVAVARRNILNAAIQQKKAELGYLAARLGPNVAEWERLVYEAFEGILENCEGPSILPVQGSPHLDETPGPAVREFNCWRSQVMSPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBU8</accession>
    <name>C7ZBU8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_9940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698916">
        <property type="protein sequence ID" value="EEU38473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044186.1">
        <property type="nucleotide sequence ID" value="XM_003044140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBU8"/>
    <dbReference type="GeneID" id="9670527"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_9940"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_9940"/>
    <dbReference type="eggNOG" id="KOG1121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009123_17_3_1"/>
    <dbReference type="InParanoid" id="C7ZBU8"/>
    <dbReference type="OMA" id="NDALAWW"/>
    <dbReference type="OrthoDB" id="5099370at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47611:SF1">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47611">
        <property type="entry name" value="HAT DIMERISATION DOMAIN, C-TERMINAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="65" mass="7545" checksum="B35B5321EDAC0E2E" modified="2009-10-13" version="1" fragment="single">WQDNRAQYPRLSRMALDFLTIQPMPAECERLFSAAGRLVTPLRSRLEVNIIGMCLVLRSWLQAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBX2</accession>
    <name>C7ZBX2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amine oxidase</fullName>
            <ecNumber evidence="11">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_55285</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="11">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="10">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10 11">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="11"/>
    <dbReference type="EMBL" id="GG698916">
        <property type="protein sequence ID" value="EEU38441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044154.1">
        <property type="nucleotide sequence ID" value="XM_003044108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBX2"/>
    <dbReference type="STRING" id="660122.C7ZBX2"/>
    <dbReference type="GeneID" id="9670541"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55285"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55285"/>
    <dbReference type="eggNOG" id="KOG1186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011500_3_1_1"/>
    <dbReference type="InParanoid" id="C7ZBX2"/>
    <dbReference type="OMA" id="MWRHTES"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000026">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF33">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="13">
        <location>
            <begin position="6"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="12">
        <location>
            <begin position="244"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="9">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="10">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU38441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="681" mass="77087" checksum="DDDB25953A825FA9" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCA5</accession>
    <name>C7ZCA5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">hydroxymethylglutaryl-CoA lyase</fullName>
            <ecNumber evidence="3">4.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_34636</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:24404"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="4.1.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.4" evidence="3"/>
    <dbReference type="EMBL" id="GG698918">
        <property type="protein sequence ID" value="EEU38337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044050.1">
        <property type="nucleotide sequence ID" value="XM_003044004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCA5"/>
    <dbReference type="STRING" id="660122.C7ZCA5"/>
    <dbReference type="GeneID" id="9670375"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_34636"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_34636"/>
    <dbReference type="eggNOG" id="KOG1680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2368">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022138_4_1_1"/>
    <dbReference type="InParanoid" id="C7ZCA5"/>
    <dbReference type="OMA" id="KEFQAGR"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="UniPathway" id="UPA00896">
        <property type="reaction ID" value="UER00863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004419">
        <property type="term" value="F:hydroxymethylglutaryl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046951">
        <property type="term" value="P:ketone body biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07938">
        <property type="entry name" value="DRE_TIM_HMGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000071">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004283">
        <property type="entry name" value="PRK05692.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738:SF17">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="7">
        <location>
            <begin position="5"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU38337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="592" mass="63665" checksum="7848EC391952720D" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZD29</accession>
    <name>C7ZD29_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_48020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698919">
        <property type="protein sequence ID" value="EEU38146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043859.1">
        <property type="nucleotide sequence ID" value="XM_003043813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZD29"/>
    <dbReference type="STRING" id="660122.C7ZD29"/>
    <dbReference type="GeneID" id="9670024"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_48020"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_48020"/>
    <dbReference type="eggNOG" id="KOG1211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020129_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZD29"/>
    <dbReference type="OMA" id="TGEGWFF"/>
    <dbReference type="OrthoDB" id="5423360at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310:SF7">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988034" description="Amidase domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="192"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU38146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="632" mass="68398" checksum="DE4B781475CF1D3A" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZD60</accession>
    <name>C7ZD60_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_71531</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698919">
        <property type="protein sequence ID" value="EEU38033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043746.1">
        <property type="nucleotide sequence ID" value="XM_003043700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZD60"/>
    <dbReference type="FunCoup" id="C7ZD60">
        <property type="interactions" value="397"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZD60"/>
    <dbReference type="GeneID" id="9670243"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_71531"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_71531"/>
    <dbReference type="eggNOG" id="KOG0854">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_4_2_1"/>
    <dbReference type="InParanoid" id="C7ZD60"/>
    <dbReference type="OMA" id="HGPMNIP"/>
    <dbReference type="OrthoDB" id="2996783at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1020.10:FF:000001">
        <property type="entry name" value="1-Cys peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF4">
        <property type="entry name" value="PEROXIREDOXIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="7"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="7">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU38033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="226" mass="25220" checksum="0BA6A9AE95E65279" modified="2009-10-13" version="1">MSAPAPLRLGSIAPNFQAETTKGKIDFHEFIGDNWVILFSHPEDYTPVCTTELGAMAKLAPEFAKRGVKPIGLSANTIESHEGWIKDISEVTGGNVEFPIIGDKERKVSLLYDMIDQQDATNVDEKGIAFTIRSVYFIDPKKTIRTILSYPASTGRNAAEILRIIDSLQTGDKYRITTPINWVPGEDVIVHPSVKNEEAKTLFPEFRIVKPYLRFTPLAKEKVVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDV0</accession>
    <name>C7ZDV0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_102202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043582.1">
        <property type="nucleotide sequence ID" value="XM_003043536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZDV0"/>
    <dbReference type="GeneID" id="9669608"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102202"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102202"/>
    <dbReference type="eggNOG" id="ENOG502QQNB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033094_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZDV0"/>
    <dbReference type="OMA" id="DTVFVPW"/>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="2">
        <location>
            <begin position="86"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU37869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="400" mass="45907" checksum="2F7B0826DD051208" modified="2009-10-13" version="1">MATRQRTSTTVVVEKPSAKVTLEPQQQPQFPDIKTIKDAIPAHCFQPSLFTSFYYVFRDFAMVATLVWAALTYIPAIPDQRLRVAAWMVYGFVQGLVCTGVWILGHECGHGAFSTHGKLNNVVGWFLHSFLLVPYFSWKYSHHRHHRFTGHMDLDMAFVPATQPKKHSILAGIDLNELFEDTPIAQLIRIVFHQLFGWQVYLLFNASAGKGSKQWEPTGLAKWFRVSHFEPTSAVFRPSEAIFIFISDLGLAITFTALYFASKAVGTSTVLFLYAVPYFWVHHWLVAITYLHHHHTEVPHYTNEGWTYVKGALATVDREFGFIGKHLFHGIIEKHVVHHLFPRIPFYKADEATEAIKPLLGDLYYHDERNFIGQLWSVFGSLKYVEHDPTNQGAMRWAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZE59</accession>
    <name>C7ZE59_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">beta-glucosidase</fullName>
            <ecNumber evidence="10">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_72948</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="10"/>
    <dbReference type="EMBL" id="GG698921">
        <property type="protein sequence ID" value="EEU37677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043390.1">
        <property type="nucleotide sequence ID" value="XM_003043344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZE59"/>
    <dbReference type="STRING" id="660122.C7ZE59"/>
    <dbReference type="GeneID" id="9665387"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_72948"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_72948"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_4_0_1"/>
    <dbReference type="InParanoid" id="C7ZE59"/>
    <dbReference type="OMA" id="SQGCYGH"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000006">
        <property type="entry name" value="Beta-glucosidase H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF27">
        <property type="entry name" value="BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="11">
        <location>
            <begin position="393"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU37677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="844" mass="91653" checksum="3045DA887B7EEA58" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZF13</accession>
    <name>C7ZF13_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_86423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043240.1">
        <property type="nucleotide sequence ID" value="XM_003043194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZF13"/>
    <dbReference type="STRING" id="660122.C7ZF13"/>
    <dbReference type="GeneID" id="9665235"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86423"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86423"/>
    <dbReference type="eggNOG" id="ENOG502RW4S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002639_9_0_1"/>
    <dbReference type="InParanoid" id="C7ZF13"/>
    <dbReference type="OMA" id="FDWDSQS"/>
    <dbReference type="OrthoDB" id="2958217at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="222"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="711" mass="79729" checksum="68DD7D727BDCE49A" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFW5</accession>
    <name>C7ZFW5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_8139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698924">
        <property type="protein sequence ID" value="EEU37130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042843.1">
        <property type="nucleotide sequence ID" value="XM_003042797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFW5"/>
    <dbReference type="STRING" id="660122.C7ZFW5"/>
    <dbReference type="GeneID" id="9664959"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_8139"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_8139"/>
    <dbReference type="eggNOG" id="KOG2551">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051938_4_2_1"/>
    <dbReference type="InParanoid" id="C7ZFW5"/>
    <dbReference type="OMA" id="FKWINGF"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF4">
        <property type="entry name" value="ESTERASE ALNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU37130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="243" mass="26932" checksum="395AFBAAAC1A6903" modified="2009-10-13" version="1" fragment="single">MKFLCLHGSYGSASNFKIQLGPFTDVVQNSGSSTFKWIDGGHKAIPPPGFDDYFGAPPLFRFMDYDGVGGLDDMMVKIRDFPKGMTPEDTIRKLLGEDDLFTTDAVHSALDRLHEIIDQDPEIDGILGYSEGATIAASLVLEERRRFEEKGIPRRIKAAIFFAGWPPIRLTDENRVECLLADECEDIIDVPTCHVVGCNDPYIQGAMALYGMCDEDTAVLFDHGKGHTLPRDTRTINELATAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZG68</accession>
    <name>C7ZG68_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_52100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698924">
        <property type="protein sequence ID" value="EEU37112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042825.1">
        <property type="nucleotide sequence ID" value="XM_003042779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZG68"/>
    <dbReference type="GeneID" id="9664941"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_52100"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_52100"/>
    <dbReference type="eggNOG" id="ENOG502SI6I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019706_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZG68"/>
    <dbReference type="OMA" id="SFAINVF"/>
    <dbReference type="OrthoDB" id="6220758at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058664">
        <property type="entry name" value="ARB_00930-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051478">
        <property type="entry name" value="Beta-lactamase-like_AB/R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935:SF97">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935">
        <property type="entry name" value="PENICILLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26335">
        <property type="entry name" value="ARB_00930_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988820" evidence="1">
        <location>
            <begin position="20"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="100"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-like ARB-00930-like C-terminal" evidence="3">
        <location>
            <begin position="412"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU37112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="565" mass="59979" checksum="89F218E5EBCE195F" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZGB6</accession>
    <name>C7ZGB6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_80988</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698925">
        <property type="protein sequence ID" value="EEU36887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003042554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZGB6"/>
    <dbReference type="STRING" id="660122.C7ZGB6"/>
    <dbReference type="GeneID" id="9669838"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_80988"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_80988"/>
    <dbReference type="eggNOG" id="ENOG502SHZK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014662_0_1_1"/>
    <dbReference type="InParanoid" id="C7ZGB6"/>
    <dbReference type="OMA" id="HVFAQPD"/>
    <dbReference type="OrthoDB" id="189997at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="75"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU36887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="686" mass="77958" checksum="05A4A8ED00B63237" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZH01</accession>
    <name>C7ZH01_FUSV7</name>
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        <recommendedName>
            <fullName evidence="2">(S)-ureidoglycine aminohydrolase cupin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_86501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698927">
        <property type="protein sequence ID" value="EEU36697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042410.1">
        <property type="nucleotide sequence ID" value="XM_003042364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZH01"/>
    <dbReference type="GeneID" id="9669490"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86501"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86501"/>
    <dbReference type="eggNOG" id="ENOG502RITS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1001327_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZH01"/>
    <dbReference type="OMA" id="GIAGCNE"/>
    <dbReference type="OrthoDB" id="4985233at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008579">
        <property type="entry name" value="UGlyAH_Cupin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40943:SF1">
        <property type="entry name" value="CYTOPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40943">
        <property type="entry name" value="CYTOPLASMIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05899">
        <property type="entry name" value="Cupin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="(S)-ureidoglycine aminohydrolase cupin" evidence="2">
        <location>
            <begin position="215"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU36697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="274" mass="29420" checksum="DCF0FD5C78DD85A0" modified="2009-10-13" version="1">MATVHELEHGSRSTTGTWTPFDWEDPVFGPQSKGEVVTIRSGGTSGSLAAGLWRTGPGIAGCNDDGTCDVVYSAPLGDETMLLLEGSAEVTIKSSGKKYRLEAGTIISHPKHVQVSWHVTTPFLKKFWVIWDGTTPGTKLDDGIVSNINHNPQGWAPFTWEEPGKGQQAVGEFTLIRNTGSTGSLEVGLWRTGRGIPGCNEDGSASFEYSSPLGDETIMLLEGLVTIVEHESGKTHKFQAGDIIALPSGLKVSWTSEGPFVKTYFVATNDKPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHG6</accession>
    <name>C7ZHG6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_102694</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="GG698928">
        <property type="protein sequence ID" value="EEU36540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042253.1">
        <property type="nucleotide sequence ID" value="XM_003042207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHG6"/>
    <dbReference type="STRING" id="660122.C7ZHG6"/>
    <dbReference type="GeneID" id="9669358"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102694"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102694"/>
    <dbReference type="eggNOG" id="KOG0417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_13_3_1"/>
    <dbReference type="InParanoid" id="C7ZHG6"/>
    <dbReference type="OMA" id="ADLHTWH"/>
    <dbReference type="OrthoDB" id="9978460at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000060">
        <property type="entry name" value="Ubiquitin conjugating enzyme (UbcB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="2"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU36540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="161" mass="18160" checksum="1D1D48DAC8F590A0" modified="2009-10-13" version="1">MSSTKRITKEFAEISQEPPEGFTVSLPPNESIHTWHVTLQPPPSTPYHPGRFGIVLSLPTDYPFKPPVVKFCTRIYHPNVTNDSLGNICLGLLKPDAWKPSTKIRAVLEALANLLEEPQLDSPLEERIAQQYQSEREAFDKTAKQHVERYAMGEPVFPPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZI43</accession>
    <name>C7ZI43_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_86937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698929">
        <property type="protein sequence ID" value="EEU36378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042091.1">
        <property type="nucleotide sequence ID" value="XM_003042045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZI43"/>
    <dbReference type="GeneID" id="9674361"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86937"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86937"/>
    <dbReference type="eggNOG" id="ENOG502RX75">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008809_1_3_1"/>
    <dbReference type="InParanoid" id="C7ZI43"/>
    <dbReference type="OMA" id="WLDQREV"/>
    <dbReference type="OrthoDB" id="5322539at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041:SF6">
        <property type="entry name" value="FORMYLMETHIONINE DEFORMYLASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="558"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU36378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="673" mass="74597" checksum="221BE3D5C54243F3" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZIA0</accession>
    <name>C7ZIA0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_87073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698930">
        <property type="protein sequence ID" value="EEU36168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041881.1">
        <property type="nucleotide sequence ID" value="XM_003041835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZIA0"/>
    <dbReference type="GeneID" id="9674243"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87073"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87073"/>
    <dbReference type="eggNOG" id="ENOG502SVIQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129944_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZIA0"/>
    <dbReference type="OMA" id="WDMVNAL"/>
    <dbReference type="OrthoDB" id="4502040at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU36168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="127" mass="13631" checksum="4BF56DF0BBC65EA6" modified="2009-10-13" version="1">MASLKSSLFYGAAAVNLLIIPKHLKVGATNVSSAIQTIPEDSPVVKRGKEVVRTAWDLTNGSLVILALLNYRWAKAGGPGSLEEKLMIVASALSGWYVGVQYFKIGMYIPLSVLWVAPVASLVAWLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJA6</accession>
    <name>C7ZJA6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_34879</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698933">
        <property type="protein sequence ID" value="EEU35817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041530.1">
        <property type="nucleotide sequence ID" value="XM_003041484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJA6"/>
    <dbReference type="STRING" id="660122.C7ZJA6"/>
    <dbReference type="GeneID" id="9673955"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_34879"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_34879"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_6_16_1"/>
    <dbReference type="InParanoid" id="C7ZJA6"/>
    <dbReference type="OMA" id="ATTICRF"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="183"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="745"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="787"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="886"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="916"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="996"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU35817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="996" mass="113142" checksum="0E6C778204C655F4" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJD9</accession>
    <name>C7ZJD9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_19687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698933">
        <property type="protein sequence ID" value="EEU35888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041601.1">
        <property type="nucleotide sequence ID" value="XM_003041555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJD9"/>
    <dbReference type="GeneID" id="9673897"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_19687"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_19687"/>
    <dbReference type="eggNOG" id="ENOG502RZ85">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1932575_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZJD9"/>
    <dbReference type="OMA" id="TADIDWQ"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU35888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="131" mass="14340" checksum="B4F3437F4C607BA4" modified="2009-10-13" version="1" fragment="single">WGKNWYSSSESLWYDRWLQVLDVLPDAIEIITWNDFSESSYIADIVPSQIVRGAEVYVDGYEHSALRSLLPYFIQAYKAGSPDVPLPNGETAVAWYRTTSATLGSDGGTVWGQDGTESASVGAKDVVSVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJJ6</accession>
    <name>C7ZJJ6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Benzoate 4-monooxygenase bphA</fullName>
            <ecNumber evidence="12">1.14.14.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Benzoate-para-hydroxylase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Cytochrome P450 monooxygenase cyp53A1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">NECHADRAFT_35086</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>benzoate + reduced [NADPH--hemoprotein reductase] + O2 = 4-hydroxybenzoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18033"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16150"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.92"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.92" evidence="12"/>
    <dbReference type="EMBL" id="GG698933">
        <property type="protein sequence ID" value="EEU35862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041575.1">
        <property type="nucleotide sequence ID" value="XM_003041529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJJ6"/>
    <dbReference type="STRING" id="660122.C7ZJJ6"/>
    <dbReference type="GeneID" id="9673946"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_35086"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_35086"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="InParanoid" id="C7ZJJ6"/>
    <dbReference type="OMA" id="FLRKPMG"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018664">
        <property type="term" value="F:benzoate 4-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000053">
        <property type="entry name" value="Cytochrome P450 benzoate 4-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF29">
        <property type="entry name" value="BENZOATE-PARA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 16 17" id="KW-0349">Heme</keyword>
    <keyword evidence="7 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="9 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 17" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEU35862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="507" mass="56622" checksum="1F7C378F5A1AD8F2" modified="2009-10-13" version="1">MALINLLISPWAPVALVVLFVGWYLVPYFGANRGLRGIPAPFPAQFSNLWLMSTCRRGKRFEVVDQVHKRLGTVVRIAPNHVSIADADAINVIYGHGNGFLKDFYDPFVSIRRGLFNTRSRAEHSRKRKIVSHTFAPKSVLEFEPYIHQNLDLFVKQWDRASSNPEADGAGRLDCLSWFNYLAFDVIADLAFGKPFGMLATGADIAEVKASPTSPAIYAPAVEIMNRRGEVSATLGCMPWLKPYAKWLPDPFFSQGLQAVENLAGIAIARVSERLERGADTTRKDLLARLMQGRDEKGEPLGRDELTAEALTQLIAGSDTTSNSSCALLYHVVKTPGVLQKLQQEIDEATADEGVIPSYESVKHLPYLGMCINETLRHHSPSGIGLPREIPAKSKGVTLHGRYFGPGTVLSVPTYTVHHSTEIWGPDAEEFKPERWENITDKQKIAFIPFSHGPRSCVGRNLAEMQMRLIAATWIKRYNIFLRQEKMETREGFLRKPLGVEIGVSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKE4</accession>
    <name>C7ZKE4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_88783</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698938">
        <property type="protein sequence ID" value="EEU35509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041222.1">
        <property type="nucleotide sequence ID" value="XM_003041176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKE4"/>
    <dbReference type="GeneID" id="9675977"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88783"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88783"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022195_0_2_1"/>
    <dbReference type="InParanoid" id="C7ZKE4"/>
    <dbReference type="OMA" id="FNDNIPM"/>
    <dbReference type="OrthoDB" id="5102441at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF6">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AN1598-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="264"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU35509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="59910" checksum="46E4A556170EE874" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-11-30" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKL5</accession>
    <name>PEP2L_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName>PEP2-like protein NECHADRAFT_97050</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">NECHADRAFT_97050</name>
    </gene>
    <organism>
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May contribute to the ability of the fungus to cause disease on pea plants.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PEP2 family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EEU35459" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="GG698940">
        <property type="protein sequence ID" value="EEU35459.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041172.1">
        <property type="nucleotide sequence ID" value="XM_003041126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKL5"/>
    <dbReference type="SMR" id="C7ZKL5"/>
    <dbReference type="GeneID" id="9675825"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_97050"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_73962"/>
    <dbReference type="InParanoid" id="C7ZKL5"/>
    <dbReference type="OrthoDB" id="2533647at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000402443" description="PEP2-like protein NECHADRAFT_97050">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="233" mass="26859" checksum="852E8D35DEDA73A7" modified="2010-11-30" version="2">MVDLHSLPIGSRPSAAIRNNGPDRLVLERLKLRELAEGWPSYRDSCEWENFESIFHPGAHVYTTWSGRVPYQDFITASKAGMDKGAFIMHRCHGTSTDINAEGTRAVTKLKAIITQRFEVDGAEFDVEADCRFCFFFEKVGSRWGAQLVRHWYEKDKMIPANPARFPAVDEERLKGYPPGYRYLAYWQEATMGVKVLLDMPGHRRHVGTPNLEKHDLLYRQAKQWLEGEQIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKT5</accession>
    <name>C7ZKT5_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_104651</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698941">
        <property type="protein sequence ID" value="EEU35356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041069.1">
        <property type="nucleotide sequence ID" value="XM_003041023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKT5"/>
    <dbReference type="FunCoup" id="C7ZKT5">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZKT5"/>
    <dbReference type="GeneID" id="9675664"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_104651"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_104651"/>
    <dbReference type="eggNOG" id="KOG2195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005688_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZKT5"/>
    <dbReference type="OMA" id="YPRKDGR"/>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF71">
        <property type="entry name" value="CARBOXYPEPTIDASE TRE2, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="4">
        <location>
            <begin position="341"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="6">
        <location>
            <begin position="528"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="5">
        <location>
            <begin position="775"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU35356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="907" mass="101471" checksum="D547BB467356F3D6" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLN9</accession>
    <name>C7ZLN9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carotenoid oxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_44844</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698946">
        <property type="protein sequence ID" value="EEU35097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040810.1">
        <property type="nucleotide sequence ID" value="XM_003040764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLN9"/>
    <dbReference type="STRING" id="660122.C7ZLN9"/>
    <dbReference type="GeneID" id="9679240"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_44844"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_44844"/>
    <dbReference type="eggNOG" id="KOG1285">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016472_1_2_1"/>
    <dbReference type="InParanoid" id="C7ZLN9"/>
    <dbReference type="OMA" id="MLPNCKA"/>
    <dbReference type="OrthoDB" id="407010at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF24">
        <property type="entry name" value="CAROTENOID ISOMEROOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002987223" description="Carotenoid oxygenase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="538"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU35097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="540" mass="59225" checksum="37FD02F47B7D4AA0" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLQ3</accession>
    <name>C7ZLQ3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_82468</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698946">
        <property type="protein sequence ID" value="EEU35103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040816.1">
        <property type="nucleotide sequence ID" value="XM_003040770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLQ3"/>
    <dbReference type="STRING" id="660122.C7ZLQ3"/>
    <dbReference type="GeneID" id="9679185"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82468"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82468"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_16_5_1"/>
    <dbReference type="InParanoid" id="C7ZLQ3"/>
    <dbReference type="OMA" id="RKFEGWS"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="12"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU35103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="341" mass="35578" checksum="3D068F30288B2815" modified="2009-10-13" version="1">MPHLAAVQPAPKAPFEVKEVETPQPGHGELLIKNEAIAIQPIDAKIARVAMLPIPYPAILGSSFAGTVTAVGPEVTGFAVGDKVVAAKTAGAVENKNSAFQRSVIASAVTTTKLPSDASLDTAVRLVGNLATVPALFQATLKLVRPDPTAAPKPQGKKILIYGGTSSIGSLSVQYLKQAGYDVVTTTSPRHEAFVSRLGASKVIDHTQDPEATVKALIAAGPYDVVVDTISTAQTVKLLADVVAAQGGGNVYALQPPFAPETLPDGVSRVFEGWSLLLAKEEHAELLKWTFATYFPQALAKDSLISVPARKIAGGLGGLDNALDILIKGVSSEKLVVDPWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLS3</accession>
    <name>C7ZLS3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_78584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698947">
        <property type="protein sequence ID" value="EEU35038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040751.1">
        <property type="nucleotide sequence ID" value="XM_003040705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLS3"/>
    <dbReference type="GeneID" id="9679140"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78584"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78584"/>
    <dbReference type="HOGENOM" id="CLU_2073779_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZLS3"/>
    <dbReference type="OrthoDB" id="5088402at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="118" mass="13362" checksum="D5EE07259C5C80A4" modified="2009-10-13" version="1">MATDGTSASKSINDMLNDVRKAAAQVKDTKAKGEDVNEAEARLDEAVNTLSRERDALSTPEHPPPETRPELSDDQLEWLKRVRRLVEREKRNTTEPREQALLEEVMKAPSYFKAKKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLX7</accession>
    <name>C7ZLX7_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NECHADRAFT_78513</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698948">
        <property type="protein sequence ID" value="EEU34973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040686.1">
        <property type="nucleotide sequence ID" value="XM_003040640.1"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZLX7"/>
    <dbReference type="GeneID" id="9679118"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78513"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78513"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3717">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_31_1_1"/>
    <dbReference type="InParanoid" id="C7ZLX7"/>
    <dbReference type="OMA" id="LRQNSVM"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05274">
        <property type="entry name" value="KR_FAS_SDR_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF22">
        <property type="entry name" value="SYNTHASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="13">
        <location>
            <begin position="6"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="14">
        <location>
            <begin position="994"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="12">
        <location>
            <begin position="2350"/>
            <end position="2427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="436"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="10">
        <location>
            <begin position="994"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="10">
        <location>
            <begin position="1163"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="445"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="10">
        <location>
            <position position="1026"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="10">
        <location>
            <position position="1228"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="2768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU34973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="3044" mass="334751" checksum="A255AE99804E9006" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZM93</accession>
    <name>C7ZM93_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_88373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698950">
        <property type="protein sequence ID" value="EEU34853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040566.1">
        <property type="nucleotide sequence ID" value="XM_003040520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZM93"/>
    <dbReference type="GeneID" id="9678985"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88373"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88373"/>
    <dbReference type="eggNOG" id="ENOG502SY0D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049634_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZM93"/>
    <dbReference type="OMA" id="QFRANSV"/>
    <dbReference type="OrthoDB" id="5237031at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU34853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="350" mass="39710" checksum="2E7EEB714BED92A2" modified="2009-10-13" version="1">MAAVPTTIRALLHEHSTNPVKDTLMESSSNKQWAKTYHPIKHLVVHTQAQGPGVVGTFDRAFLGEYDDENLRLNEPAYPPNYRNWRMDTEQDAIAWFNAEVSNVVLSAFAVYPGVMNCGHEKPLSSTRTDETVDTSYSIDASGGRTNLVIGEFKRGTLKRARWQAGSLGSGQESLSRELRGYAHKYECPHIFCFDGYTLLLLQFQAKSPNEIKDAKCVVDCWVFPRDNPHGTPLRYALYRFLVQGFRRCQGTRATKMSLYGVRPTLRLFYSGLPLWKLEDGNFYANPWGHERKLDASCGAFYWTDKDGRVPLLGGDNNWVWDTESFWQTLTQQSEGDSVPMVVEDLYGPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMS3</accession>
    <name>C7ZMS3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_44664</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698958">
        <property type="protein sequence ID" value="EEU34686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040399.1">
        <property type="nucleotide sequence ID" value="XM_003040353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMS3"/>
    <dbReference type="STRING" id="660122.C7ZMS3"/>
    <dbReference type="GeneID" id="9678829"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_44664"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_44664"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_9_4_1"/>
    <dbReference type="InParanoid" id="C7ZMS3"/>
    <dbReference type="OMA" id="REMIDTF"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF562">
        <property type="entry name" value="ALDEHYDE REDUCTASE II (AFU_ORTHOLOGUE AFUA_1G11360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="14"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU34686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="258" mass="27870" checksum="CC91F50D4520CBA7" modified="2009-10-13" version="1">MPPVEATIPSGSLVLVTGATGFVASHVTRQLLERGYRVRGTVRELAQASWLIDNHFKSYSESGHLELIEVPDLVADGAFNEAVKGVSAIAHIATISNLDPNPHNIIPQTVAGATGILKSAANEPSLRRVVFTSSIMAAVLPVAGNDTRVDDDTWNEAAVEAAWAPPPYEPARTLITYAASKVAAEREVWRFVEQEKPHYTLNVICPSGIIGEPLHRKHAEAPTNWIATHFRRDKTSLDAFPAGKALDSSVYGLLSNHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZN99</accession>
    <name>C7ZN99_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_88027</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698964">
        <property type="protein sequence ID" value="EEU34531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040244.1">
        <property type="nucleotide sequence ID" value="XM_003040198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZN99"/>
    <dbReference type="GeneID" id="9678066"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88027"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88027"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_25_1_1"/>
    <dbReference type="InParanoid" id="C7ZN99"/>
    <dbReference type="OMA" id="RYIFWIQ"/>
    <dbReference type="OrthoDB" id="4161376at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06179">
        <property type="entry name" value="MFS_TRI12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053791">
        <property type="entry name" value="MFS_Tri12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF195">
        <property type="entry name" value="PEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="44"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU34531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="583" mass="62185" checksum="49727A6E38D34981" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPI3</accession>
    <name>C7ZPI3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fatty acid synthase subunit alpha</fullName>
            <ecNumber evidence="3">1.1.1.100</ecNumber>
            <ecNumber evidence="4">2.3.1.41</ecNumber>
            <ecNumber evidence="2">2.3.1.86</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">NECHADRAFT_72277</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 22">Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EC" id="2.3.1.41" evidence="4"/>
    <dbReference type="EC" id="2.3.1.86" evidence="2"/>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040066.1">
        <property type="nucleotide sequence ID" value="XM_003040020.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="C7ZPI3">
        <property type="interactions" value="360"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZPI3"/>
    <dbReference type="GeneID" id="9677740"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_72277"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_72277"/>
    <dbReference type="eggNOG" id="ENOG502QQJX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000114_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZPI3"/>
    <dbReference type="OMA" id="FPTLPDW"/>
    <dbReference type="OrthoDB" id="4251012at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
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    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:mitotic nuclear membrane biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="P:palmitic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:secondary metabolite biosynthetic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="elong_cond_enzymes"/>
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        <property type="entry name" value="KR_fFAS_SDR_c_like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Fatty acid synthase alpha subunit FasA"/>
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        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
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        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
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        <property type="entry name" value="ACPS"/>
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        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
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        <property type="entry name" value="Fas_alpha_ACP"/>
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        <property type="entry name" value="FAS_alpha_su_C"/>
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        <property type="entry name" value="FAS_alpha_yeast"/>
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        <property type="entry name" value="FASI_helical"/>
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    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
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    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
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    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
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        <property type="entry name" value="Ketoacyl_synth_N"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
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        <property type="entry name" value="PP-bd_ACP"/>
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        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
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        <property type="entry name" value="SDR_fam"/>
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        <property type="entry name" value="Thiolase-like"/>
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        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Fas_alpha_ACP"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FabD/lysophospholipase-like"/>
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        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 24" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 24" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0521">NADP</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 22 25" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 22" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="26">
        <location>
            <begin position="141"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="27">
        <location>
            <begin position="1092"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="23">
        <location>
            <position position="1275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1746"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1747"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1748"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1846"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1847"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="25">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRNR" id="PIRNR000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="EEU34353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1860" mass="204566" checksum="613CA03ECA10D507" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPI9</accession>
    <name>C7ZPI9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_85733</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003040023.1"/>
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    <dbReference type="STRING" id="660122.C7ZPI9"/>
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    <dbReference type="KEGG" id="nhe:NECHADRAFT_85733"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85733"/>
    <dbReference type="eggNOG" id="ENOG502QW0K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007003_6_0_1"/>
    <dbReference type="InParanoid" id="C7ZPI9"/>
    <dbReference type="OMA" id="YIAHTAC"/>
    <dbReference type="OrthoDB" id="2162761at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="43"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="834"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU34356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="881" mass="98166" checksum="CD219D4427EBC22B" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPK9</accession>
    <name>C7ZPK9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="8">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_72308</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="8"/>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040081.1">
        <property type="nucleotide sequence ID" value="XM_003040035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZPK9"/>
    <dbReference type="FunCoup" id="C7ZPK9">
        <property type="interactions" value="448"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZPK9"/>
    <dbReference type="GeneID" id="9677751"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_72308"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_72308"/>
    <dbReference type="eggNOG" id="KOG2951">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044118_1_2_1"/>
    <dbReference type="InParanoid" id="C7ZPK9"/>
    <dbReference type="OMA" id="ERGLHPW"/>
    <dbReference type="OrthoDB" id="10254945at2759"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000004">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000012">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854:SF4">
        <property type="entry name" value="INOSITOL-1-MONOPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU34368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="297" mass="31877" checksum="839BAD90AEDFAF99" modified="2009-10-13" version="1">MADLDLKAVHDEMVSVAYEAGVMILAANPAELDTDTKLNSVDIVTEADKGVEKMVSARLSSAFPSISFMGEETYKPGMRLGPEPTFVVDPIDGTTNFVHSFPAACISLGLAVDRQPAVGVIYNPWQDTLYTAIKGQGAFLTRGRSSEPQRLPLARTPRPIEGLGSSLVGVEWGSTRDGPNFDLKVETFRRLAGSKETGGAMVHSLRSLGSAALNLAAVAAGQLDLYWEGGCWAWDVCAGWCLLNEAGGRMVHGNPGEWDVELESRVYLAVRGAPSGQKELIEEFWGVLNGGKLDYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZRC6</accession>
    <name>C7ZRC6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_56707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699060">
        <property type="protein sequence ID" value="EEU33433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039146.1">
        <property type="nucleotide sequence ID" value="XM_003039100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZRC6"/>
    <dbReference type="GeneID" id="9666666"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_56707"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_56707"/>
    <dbReference type="eggNOG" id="ENOG502RR6X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_34_22_1"/>
    <dbReference type="InParanoid" id="C7ZRC6"/>
    <dbReference type="OMA" id="YNAICVE"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09008">
        <property type="entry name" value="MTAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="2">
        <location>
            <begin position="12"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU33433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="335" mass="36620" checksum="7B0B1A7C19451516" modified="2009-10-13" version="1">MGCRTYSRQVYKVGIIGALWKELKAVRALFDSEHGSLEREEGDDNQYALGAMANHMVVTACLPAGEYGTNSAASVASNMVRSFPALKFCLLVGIAGGAPSEHNDIRLGDVVVGIPEGRSPSVVQYDLGKDKESNIFEPTGRLRDPPRFLASAVSALLSVPNPPSDPLKPHLAKITKLMSEYRRPAQEDVLYETCTACRSSEKVCPGYHVRQRVPRPTTIHYGPIGSGNSVIKNAKRRDELAREHGVLCFEMEAAGVVNAVPCLVIRGICDYCDVHKNDDWQNYAAATAAAYSKLLLGVDRCKKTGLNDDYQGNFHSTSPKTSAGSKRRRSEFEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C7YH21</accession>
    <name>C7YH21_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_57390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053553.1">
        <property type="nucleotide sequence ID" value="XM_003053507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YH21"/>
    <dbReference type="GeneID" id="9664428"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_57390"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_57390"/>
    <dbReference type="eggNOG" id="ENOG502QVRM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005537_0_0_1"/>
    <dbReference type="InParanoid" id="C7YH21"/>
    <dbReference type="OMA" id="LGANCPC"/>
    <dbReference type="OrthoDB" id="5315052at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058925">
        <property type="entry name" value="zf-C2H2_AcuF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26082">
        <property type="entry name" value="zf-C2H2_AcuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="890"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="441"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="542"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="717"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="490"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="542"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1071"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU47840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1071" mass="118279" checksum="C5DC21693A9C4FAC" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHB8</accession>
    <name>C7YHB8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_90144</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054317.1">
        <property type="nucleotide sequence ID" value="XM_003054271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YHB8"/>
    <dbReference type="GeneID" id="9674478"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90144"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90144"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_0_1"/>
    <dbReference type="InParanoid" id="C7YHB8"/>
    <dbReference type="OMA" id="YKITEMT"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43490">
        <property type="entry name" value="(+)-NEOMENTHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43490:SF99">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="11"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU48604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="250" mass="26667" checksum="66359AC2A14668D3" modified="2009-10-13" version="1">MSPNTITPENTIVLVTGANQGIGLEVVKKLTAEHPDYHVILSGRRPDAVQEAASSFQAKGLRVSPLVLDITSDESIAAAAKSIKDTYGRLDVLINNSAISGLSLDVSPRARMQTVFDTNVIGTSLVTDALIPLLERSSKTRRIVFVTSALGSLARKADPASALHKPEYGVYTYSKSALNMMALHYAIRYEEDPQWKINIVCPGHHCGTTLNGFQGAEDPSLGAVSICQAATLGADGKTGTFTDDKGTIPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHR2</accession>
    <name>C7YHR2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_65727</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053669.1">
        <property type="nucleotide sequence ID" value="XM_003053623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YHR2"/>
    <dbReference type="FunCoup" id="C7YHR2">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YHR2"/>
    <dbReference type="GeneID" id="9674617"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_65727"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_65727"/>
    <dbReference type="eggNOG" id="ENOG502QPQM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030747_0_1_1"/>
    <dbReference type="InParanoid" id="C7YHR2"/>
    <dbReference type="OMA" id="WSIYDAQ"/>
    <dbReference type="OrthoDB" id="5784at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006676">
        <property type="term" value="P:mannosyl diphosphorylinositol ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000015">
        <property type="entry name" value="Aureobasidin resistance protein Aur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF11">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE CATALYTIC SUBUNIT AUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="6">
        <location>
            <begin position="209"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU47956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="455" mass="51205" checksum="CDAFC68B49EC0464" modified="2009-10-13" version="1">MNDFPTLSGKPKLQLLWPDHLNLPFLNTAVPQRYRIGRRRTKSKSGPGNEEITGLKTSFNAWDGVRDFQKHKWATSDLQYVFLALLALFCLWIAPPAPGVKLLAVVGSVWLVLMPATRQFFLPSSMIWIWLLYFFCSRFIPYEVRPHIWVRVLPALENVLYGANLSSILSAHQHPVLDILAWVPYGLCHFGAPAVCALILWIFGAPGTTPVFARTFGWMSILGVTIQLVFPCTPPWYENEHGLEPAAYGMPGSPAGLARIDAIFGIDLYTTNFSSAPVPFGAFPSLHAANAVLEALFMTHCFPQFRTYFILYAGWVWWATMYLSHHYAIDLVCGGLIAASFYYVAKARWLPRNQEDKITRWEYEYVEYGDRNTITDEEYGEYFGLGLLGRPRADSSDGWTVASASSYSSSSGTLSPTLSEEALPHMLMDLDENGHSWEGQNRPRDVELSEVVVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHR9</accession>
    <name>C7YHR9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Disintegrin and metalloproteinase domain-containing protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_98871</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Probable zinc protease.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054401.1">
        <property type="nucleotide sequence ID" value="XM_003054355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YHR9"/>
    <dbReference type="STRING" id="660122.C7YHR9"/>
    <dbReference type="GeneID" id="9674620"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_98871"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98871"/>
    <dbReference type="eggNOG" id="KOG3607">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012383_1_0_1"/>
    <dbReference type="InParanoid" id="C7YHR9"/>
    <dbReference type="OMA" id="YGLQQNF"/>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04271">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000003">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034028">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF159">
        <property type="entry name" value="ADAM METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13688">
        <property type="entry name" value="Reprolysin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988314" description="Disintegrin and metalloproteinase domain-containing protein B" evidence="7">
        <location>
            <begin position="24"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="698"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="9">
        <location>
            <begin position="269"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="8">
        <location>
            <begin position="510"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="753"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="762"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00056552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00074021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU48688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="785" mass="85123" checksum="2183CF1514AA2D69" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C7YII8</accession>
    <name>C7YII8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">NECHADRAFT_31235</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054527.1">
        <property type="nucleotide sequence ID" value="XM_003054481.1"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YII8"/>
    <dbReference type="GeneID" id="9676448"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_31235"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_31235"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_233900_0_0_1"/>
    <dbReference type="InParanoid" id="C7YII8"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045033">
        <property type="term" value="P:peroxisome inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000016">
        <property type="entry name" value="Membrane bound cation transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000397">
        <property type="entry name" value="Serine/threonine-protein kinase KIN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000011">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF18">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1369"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1397"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1431"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1459"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1495"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1534"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1909"/>
            <end position="1936"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1942"/>
            <end position="1963"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1970"/>
            <end position="1990"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="261"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="205"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="594"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="805"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="993"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1162"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1199"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1260"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1572"/>
            <end position="1757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="696"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="843"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="933"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="958"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1024"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1261"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1301"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1583"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="1606"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1624"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1639"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="1683"/>
            <end position="1700"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EEU48814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="2001" mass="217071" checksum="03C38038A62473AF" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIZ5</accession>
    <name>C7YIZ5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Translin-associated protein X</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_99004</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053892.1">
        <property type="nucleotide sequence ID" value="XM_003053846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIZ5"/>
    <dbReference type="STRING" id="660122.C7YIZ5"/>
    <dbReference type="GeneID" id="9676528"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_99004"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_99004"/>
    <dbReference type="eggNOG" id="KOG3066">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067225_2_1_1"/>
    <dbReference type="InParanoid" id="C7YIZ5"/>
    <dbReference type="OMA" id="DTCMETC"/>
    <dbReference type="OrthoDB" id="31005at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14820">
        <property type="entry name" value="TRAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="233"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU48179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="28898" checksum="88FC5E3D8B02FA6A" modified="2009-10-13" version="1">MSSGVKRDRDGNARAKGPGYKQQQPRGRFHDMFEGFRDELDEHHDRRERIVKASRDVTAQSKKIVKQLNKDFPPNIQQDMDTRLAEITKLLKAIAPDLQEVNRYRYTSPLRCLEEFVEALSFAHYLRHQKLITPEETQKAMPANLLLTPNDYMYGVFDLFGELMRFATVTTAQTGELAGVEDRNIMGDIQELGCAFEILPDVPTKDWRGKMGAMRQSVKKVEKLGYGLVVRGSERPKGWVPDMKDDAPEPSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJB2</accession>
    <name>C7YJB2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_99023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053953.1">
        <property type="nucleotide sequence ID" value="XM_003053907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJB2"/>
    <dbReference type="STRING" id="660122.C7YJB2"/>
    <dbReference type="GeneID" id="9676584"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_99023"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_99023"/>
    <dbReference type="eggNOG" id="KOG1818">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037982_1_0_1"/>
    <dbReference type="InParanoid" id="C7YJB2"/>
    <dbReference type="OMA" id="TRCWYEM"/>
    <dbReference type="OrthoDB" id="5407799at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19817">
        <property type="entry name" value="Bbox1_ANCHR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044553">
        <property type="entry name" value="Bbox1_ANCHR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46603">
        <property type="entry name" value="ABSCISSION/NOCUT CHECKPOINT REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46603:SF1">
        <property type="entry name" value="ABSCISSION_NOCUT CHECKPOINT REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU48240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="365" mass="39804" checksum="3BC1F61ACB9F3D12" modified="2009-10-13" version="1">MPNDVDKSLLDRLQALRGGSATPEKPAATHINVDLIERRKTPTREDALAARLKSLRSQDEASPSAPKTSPQVSRPAPAPSSSPSPLIRKTSKDEPQKLDDDDDVDAMFQTDDQTLEELLGDVKPGEGFQVEPDDEQVKALLEELADSIPQDTEDGVKGSSKDKDDSDDSDGETMNKEIDDVIARFRDEVEIEAALNKDKTPEPESESEDEGQEKDTASKDVDLDLPDLPSNLDALPTAPASSARAGSADIDDITARLAALRAPSPSASDSFSLPSVPTSKPSGKPINRLTSRTNYTDDDMDSWCTVCLEDATLRCPGCDDDVYCTRCWREMHIGPQAGFDERNHKAVQFTKDRKKKEKRKVALGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJN1</accession>
    <name>C7YJN1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_75737</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
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                <person name="Rodriguez-Carres M."/>
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</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
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</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
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                <person name="Rodriguez-Carres M."/>
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                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
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                <person name="Danchin E.G."/>
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                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
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                <person name="Gribskov M."/>
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                <person name="Salamov A."/>
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                <person name="Geiser D.M."/>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003054160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YKQ2"/>
    <dbReference type="FunCoup" id="C7YKQ2">
        <property type="interactions" value="500"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YKQ2"/>
    <dbReference type="GeneID" id="9664287"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_57350"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_57350"/>
    <dbReference type="eggNOG" id="KOG0236">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003182_8_1_1"/>
    <dbReference type="InParanoid" id="C7YKQ2"/>
    <dbReference type="OMA" id="TLYQFWR"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000024">
        <property type="entry name" value="Sulfate permease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="573"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="606"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="607"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU48493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="818" mass="89094" checksum="BC363A1E03A7D219" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7YL71</accession>
    <name>C7YL71_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_36336</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052449.1">
        <property type="nucleotide sequence ID" value="XM_003052403.1"/>
    </dbReference>
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    <dbReference type="STRING" id="660122.C7YL71"/>
    <dbReference type="GeneID" id="9663613"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_36336"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_36336"/>
    <dbReference type="eggNOG" id="ENOG502SNYU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_8_4_1"/>
    <dbReference type="InParanoid" id="C7YL71"/>
    <dbReference type="OMA" id="AIHLHEA"/>
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    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAD-like_hydrolase"/>
    </dbReference>
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        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46470:SF2">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46470">
        <property type="entry name" value="N-ACYLNEURAMINATE-9-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU46736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="250" mass="28145" checksum="0CEEEBDE1A8A9BF1" modified="2009-10-13" version="1">MTLSLEPDQKKLLEALQTKTWFGFDLDDTLHEFRRASRAAVTHCLTRISNENPHIKVEDLQAQYQIVLKQGTASAFTDGKTSHDYRRERFSATLSHFKLNLDSIEKLLRDYERVLVENLTLKPGALSLLRAIKESGRKITVITEGPQDAQERAVRDLGITNYIDFLATTNHFGVAKTSGLFGKVLKHLEIQPSDIVYAGDSKERDVEPATKEGIYTIHLREDQTVSLALNPPSINSLEVLGQIVPLLEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7YMN0</accession>
    <name>C7YMN0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein SUR7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_77937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053189.1">
        <property type="nucleotide sequence ID" value="XM_003053143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YMN0"/>
    <dbReference type="FunCoup" id="C7YMN0">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="GeneID" id="9671223"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77937"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77937"/>
    <dbReference type="eggNOG" id="ENOG502RKFF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059603_2_0_1"/>
    <dbReference type="InParanoid" id="C7YMN0"/>
    <dbReference type="OMA" id="FMWTAVA"/>
    <dbReference type="OrthoDB" id="5419460at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032185">
        <property type="term" value="P:septin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36414">
        <property type="entry name" value="PROTEIN SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36414:SF1">
        <property type="entry name" value="PROTEIN SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU47476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="26864" checksum="9934AE8F3DDA4E32" modified="2009-10-13" version="1">MAKHAPLGLAALVLLAASLLFLWFIILSGLNNTTPLNKTYFLRADTSDITGARDVTQWTFFYICGAGNKDCSGARPGPSIGRAWSSNPSGAPDSLVGGRDGDRTSTEYFLLWRFGWVFILITLFFETVAFFAGFLACCGRLGAAISGCFSALALLCSSVAMSLMTATFVKARDAFKSDGRSAHLGRYAFGFAWASWAALFLATVLFFLGLRSDKSASSGGHSGRTWRRNRSVRSTTGYDGRRVKDDYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7YMT3</accession>
    <name>C7YMT3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_77987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052720.1">
        <property type="nucleotide sequence ID" value="XM_003052674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YMT3"/>
    <dbReference type="GeneID" id="9671252"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77987"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77987"/>
    <dbReference type="eggNOG" id="ENOG502QV05">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_531084_0_0_1"/>
    <dbReference type="InParanoid" id="C7YMT3"/>
    <dbReference type="OrthoDB" id="5094609at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU47007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="513" mass="55293" checksum="040A15C768AEE0B7" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNM0</accession>
    <name>C7YNM0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Selenoprotein W-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_79352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051856.1">
        <property type="nucleotide sequence ID" value="XM_003051810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNM0"/>
    <dbReference type="GeneID" id="9670831"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79352"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79352"/>
    <dbReference type="eggNOG" id="ENOG502S6UH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068510_1_2_1"/>
    <dbReference type="InParanoid" id="C7YNM0"/>
    <dbReference type="OMA" id="EYCTQCR"/>
    <dbReference type="OrthoDB" id="60822at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02174">
        <property type="entry name" value="CXXU_selWTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417:SF2">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU46143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16144" checksum="04F8483DBF0B349F" modified="2009-10-13" version="1">MASQVPQSTALPRVAIQFCTQCKWNLRAAYYAQELLSTFSDVLGEVALQPSTGGTFIVSITHQAPEAETASTKVLWDRREDGGFPETKELKRRVRDVVEPGRDLGHVDGKHAKKTEENKAAQPQQAEEKAVQGEASQGGDEKCEDCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNV8</accession>
    <name>C7YNV8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_79441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052356.1">
        <property type="nucleotide sequence ID" value="XM_003052310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNV8"/>
    <dbReference type="GeneID" id="9672976"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79441"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79441"/>
    <dbReference type="HOGENOM" id="CLU_497038_0_0_1"/>
    <dbReference type="InParanoid" id="C7YNV8"/>
    <dbReference type="OrthoDB" id="5093554at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU46643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="548" mass="59589" checksum="9A6AB7C27B318294" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNW2</accession>
    <name>C7YNW2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_38659</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051898.1">
        <property type="nucleotide sequence ID" value="XM_003051852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNW2"/>
    <dbReference type="GeneID" id="9670881"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_38659"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_38659"/>
    <dbReference type="eggNOG" id="ENOG502RX9H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027816_4_2_1"/>
    <dbReference type="InParanoid" id="C7YNW2"/>
    <dbReference type="OMA" id="KYFFIRT"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF683">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="51"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU46185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="471" mass="50339" checksum="BBF80DEAB8D2C817" modified="2009-10-13" version="1">MFKEKKPAQDSEGFSDGLQSPPSQNGSTYASSHVEDAVFGEVTEDGPNYRNVGWIATIALMTKTQIGLGVLSIPATFDALGLIPGVICLVVISAITTWSDYMIGVFKKRHPEVYGLDDAGFMMFGKIGREVFALIFMFYWIFVSGSAMLGISIGLNAVSTHAACTAVFVAVAAVATFGFASIRTLGKIGWLAWIGLVCIMTAIFAVTVAVGLQDRPAAAPKGGVWVSDYKLTNTPSFVDGISAISALIFAFSGTPAFFTIAAEMREPKHYTRSLLCAQGVVTVTYIAIGVVVYYYCGSYVASPALGSAGSTMKKVCYGFALPGLLVTAMIVTHVPAKYIFVRILRGSKHLNSNTLVHWGTWLGCTGGITIIAYIIASAIPVFGGLVSLIGALLGTFMCFQPYGCMWLYDNWSRKDRDLRWHLMVCWSVFVVVSGTFCMVAGTYGSVVGIMDSYKVSGGSAAWSCADNSNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNZ1</accession>
    <name>C7YNZ1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidate phosphatase APP1 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_100257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052375.1">
        <property type="nucleotide sequence ID" value="XM_003052329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNZ1"/>
    <dbReference type="STRING" id="660122.C7YNZ1"/>
    <dbReference type="GeneID" id="9672990"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100257"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100257"/>
    <dbReference type="eggNOG" id="ENOG502QT5E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008292_0_0_1"/>
    <dbReference type="InParanoid" id="C7YNZ1"/>
    <dbReference type="OMA" id="RGPMTRK"/>
    <dbReference type="OrthoDB" id="2117591at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017210">
        <property type="entry name" value="APP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF3">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037464">
        <property type="entry name" value="UCP037464_APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="2">
        <location>
            <begin position="361"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="666"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU46662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="832" mass="92259" checksum="E885EF2DA5B9ECF0" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPA7</accession>
    <name>C7YPA7_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_78693</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051524.1">
        <property type="nucleotide sequence ID" value="XM_003051478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YPA7"/>
    <dbReference type="GeneID" id="9673132"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78693"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78693"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000134_34_2_1"/>
    <dbReference type="InParanoid" id="C7YPA7"/>
    <dbReference type="OMA" id="TARMFGK"/>
    <dbReference type="OrthoDB" id="366390at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU45811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="156" mass="16719" checksum="0C0D8210EEE61F03" modified="2009-10-13" version="1">MSGPSNQPARSDSLTPEMIEFATKMYDSARIGDVAVFQQALPAGLPPNLTNEKGDTLVMLAAYHGHADLVHLLIQHGADPNRLNDRGQSPLAGAIFKKEDEVVQVLLDGGADPEHGKPSAAECITMFNQEGVWKSKFDAAPGKGQADKGRSRENRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPC7</accession>
    <name>C7YPC7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_78710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051988.1">
        <property type="nucleotide sequence ID" value="XM_003051942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YPC7"/>
    <dbReference type="GeneID" id="9668612"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78710"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78710"/>
    <dbReference type="eggNOG" id="ENOG502RHMW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1256291_0_0_1"/>
    <dbReference type="InParanoid" id="C7YPC7"/>
    <dbReference type="OMA" id="CMALWLA"/>
    <dbReference type="OrthoDB" id="5363290at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42083">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42083:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU46275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="20357" checksum="0F59BBA96F0A44CF" modified="2009-10-13" version="1">MARQWHPRAVAQVTLRGLQFIFAVISAALYGADVANWSTTNTHANASWIYAEVTAVLAALSSIAQWWLALPRPGAVVWDCVISLLWLVTVAVFAQNISNSTDMDQKFSINRIKAAVAIDGINLALWLASAVEACWCCGRKKQKQPTAEEAMEEVDIAEKKNLNDEGNVTKEKDAKVALDPPSYAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPQ3</accession>
    <name>C7YPQ3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dilute domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_68183</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the allantoicase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051604.1">
        <property type="nucleotide sequence ID" value="XM_003051558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YPQ3"/>
    <dbReference type="STRING" id="660122.C7YPQ3"/>
    <dbReference type="GeneID" id="9673273"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_68183"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_68183"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4145">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007327_0_0_1"/>
    <dbReference type="InParanoid" id="C7YPQ3"/>
    <dbReference type="OMA" id="WSQVMYW"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004037">
        <property type="term" value="F:allantoicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15473">
        <property type="entry name" value="Myo5p-like_CBD_DIL_ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000078">
        <property type="entry name" value="DAL2p Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00813">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005164">
        <property type="entry name" value="Allantoicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015908">
        <property type="entry name" value="Allantoicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037986">
        <property type="entry name" value="Myo5p-like_CBD_DIL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052072">
        <property type="entry name" value="Vascular_dev_regulator"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02961">
        <property type="entry name" value="allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027:SF6">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03561">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="582"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="4">
        <location>
            <begin position="805"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="342"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="393"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1104"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1209"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1113"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1144"/>
            <end position="1155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU45891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1230" mass="137851" checksum="F1510D4D203D6BBE" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQ23</accession>
    <name>C7YQ23_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_100025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051663.1">
        <property type="nucleotide sequence ID" value="XM_003051617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQ23"/>
    <dbReference type="STRING" id="660122.C7YQ23"/>
    <dbReference type="GeneID" id="9673409"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100025"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100025"/>
    <dbReference type="eggNOG" id="ENOG502SFH4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042426_1_0_1"/>
    <dbReference type="InParanoid" id="C7YQ23"/>
    <dbReference type="OMA" id="TPMSATY"/>
    <dbReference type="OrthoDB" id="5405654at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42053">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42053:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU45950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="228" mass="23968" checksum="965B0CF1D8529211" modified="2009-10-13" version="1">MPTAKPKLGKLTTPVTATFPSEITSATPISAISFNFKPDPDFIKTPISPPSAYTDFLTKAMALNSPAPSSGETTPDSIPDSATSEETDASSKCNITPPSSASSTSSKTSTGPSPPATAPMVPPSPFTYTAPMSAPPTGPATFPSLKLPPSPSVANLDSPLSVSTPRSPFSARPVHSVFDWDAALKARFAEKKKASRTSVRHIREVVTRTVTYTPRMAPAPKGKRRKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQ71</accession>
    <name>C7YQ71_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4110 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_37884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051681.1">
        <property type="nucleotide sequence ID" value="XM_003051635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQ71"/>
    <dbReference type="FunCoup" id="C7YQ71">
        <property type="interactions" value="649"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YQ71"/>
    <dbReference type="GeneID" id="9668910"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_37884"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_37884"/>
    <dbReference type="eggNOG" id="KOG1230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008722_0_0_1"/>
    <dbReference type="InParanoid" id="C7YQ71"/>
    <dbReference type="OMA" id="PSPRVGC"/>
    <dbReference type="OrthoDB" id="4447at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025183">
        <property type="entry name" value="DUF4110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052588">
        <property type="entry name" value="Kelch_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13422">
        <property type="entry name" value="DUF4110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4110" evidence="2">
        <location>
            <begin position="584"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="559"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU45968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="684" mass="77788" checksum="3CCE9FEEAE192FB6" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQG5</accession>
    <name>C7YQG5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type transcription factor MSN2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">NECHADRAFT_102564</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052180.1">
        <property type="nucleotide sequence ID" value="XM_003052134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQG5"/>
    <dbReference type="STRING" id="660122.C7YQG5"/>
    <dbReference type="GeneID" id="9673558"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102564"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102564"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030977_1_0_1"/>
    <dbReference type="InParanoid" id="C7YQG5"/>
    <dbReference type="OMA" id="PFFYYNP"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000141">
        <property type="entry name" value="C2H2 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000243">
        <property type="entry name" value="Probable transcription factor steA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF12">
        <property type="entry name" value="ZINC FINGER PROTEIN 208-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0843">Virulence</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="421"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="49"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="323"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="516"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEU46467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="540" mass="58218" checksum="77F7190CEDAEA6C2" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7YR65</accession>
    <name>C7YR65_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3 11">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_80283</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3 11"/>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051113.1">
        <property type="nucleotide sequence ID" value="XM_003051067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YR65"/>
    <dbReference type="FunCoup" id="C7YR65">
        <property type="interactions" value="445"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YR65"/>
    <dbReference type="GeneID" id="9665758"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_80283"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_80283"/>
    <dbReference type="eggNOG" id="KOG3754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010467_0_0_1"/>
    <dbReference type="InParanoid" id="C7YR65"/>
    <dbReference type="OMA" id="IAHMFIR"/>
    <dbReference type="OrthoDB" id="7939818at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000001">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000004">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="521"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="683"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU45400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="720" mass="80835" checksum="481AE9A9ED045FB5" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSC7</accession>
    <name>C7YSC7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sphingolipid delta(4)-desaturase</fullName>
            <ecNumber evidence="8">1.14.19.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_93811</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Delta(4)-fatty-acid desaturase which introduces a double bond at the 4-position in the long-chain base (LCB) of ceramides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = an N-acylsphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:46544"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:31488"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="1.14.19.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.17" evidence="8"/>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051326.1">
        <property type="nucleotide sequence ID" value="XM_003051280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSC7"/>
    <dbReference type="STRING" id="660122.C7YSC7"/>
    <dbReference type="GeneID" id="9666182"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_93811"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_93811"/>
    <dbReference type="eggNOG" id="KOG2987">
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    <dbReference type="OrthoDB" id="200948at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
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        <property type="component" value="Chromosome 5"/>
    </dbReference>
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        <property type="term" value="F:sphingolipid delta-4 desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03508">
        <property type="entry name" value="Delta4-sphingolipid-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011388">
        <property type="entry name" value="DES1/DES2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013866">
        <property type="entry name" value="Sphingolipid_d4-desaturase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879">
        <property type="entry name" value="SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879:SF8">
        <property type="entry name" value="SPHINGOLIPID DELTA(4)-DESATURASE DES1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08557">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017228">
        <property type="entry name" value="Sphnglp_dlt4_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01269">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingolipid delta4-desaturase N-terminal" evidence="11">
        <location>
            <begin position="31"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU45613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="373" mass="42429" checksum="71EB5FEDF481498F" modified="2009-10-13" version="1">MTAANSSTVTSRAKGDSPTPAPAGEHDDAAQKNNDFFWTYTEEPHRTRRLAIIKAHPEITKLCGPEPLTKWVVLGVVSLQVFLAWALHDTPFFSWKFWAVAYVFGATANQNLFLAIHEISHNLAFKSPRANRLIAIFANLPIGIPYSASFRPYHLTHHKSLGVDGLDTDLPTAFEAFVLDSIFGKAFFCTFQIFFYALRPMAVYRVPLTKVHFLNIAVQLTFDALLYRFASINAILYLLLSSFLAGSLHPLAGHFIAEHYVYETITPTARDPENRIPVPETFSYYGPLNWFTYNVGLHNEHHDFPAVPWTRLHAVRDIAHEFYDDLPRHESWCYAIWRFIWDENVGMTCRVKRKNGGRLVGGGANWKESEIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7YTG7</accession>
    <name>C7YTG7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamyl-tRNA synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_71645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EEU44243.1"/>
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    </dbReference>
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    <dbReference type="GeneID" id="9675115"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_71645"/>
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    <dbReference type="eggNOG" id="ENOG502S0KS">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUF4202"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41729">
        <property type="entry name" value="GLUTAMYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41729:SF1">
        <property type="entry name" value="GLUTAMYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13875">
        <property type="entry name" value="DUF4202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU44243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23352" checksum="1FFF96EDCBB81834" modified="2009-10-13" version="1">MPDSSPPLPAEYARGLELIDAAHAEDPRTASGPDGTTLPYELDYARKMTKWLALRSPSASPVLQLACRAQHFRRWEIPRSSYPMTRPGYLTWRTKLKAQAAVQVAELLASPEIQPPIPEEDRARVAALIRKENLKADEETQVLEDVACLVFLDDQFDDFESKSDLDEDKMVNILRKTWGKMGEKGHQLALEMNHSDRAKELIGKALAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7YUU5</accession>
    <name>C7YUU5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquinol-cytochrome-c reductase cytochrome c1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_85044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050580.1">
        <property type="nucleotide sequence ID" value="XM_003050534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YUU5"/>
    <dbReference type="STRING" id="660122.C7YUU5"/>
    <dbReference type="GeneID" id="9674969"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85044"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85044"/>
    <dbReference type="eggNOG" id="ENOG502SHBR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_501600_0_0_1"/>
    <dbReference type="InParanoid" id="C7YUU5"/>
    <dbReference type="OMA" id="QACFDFA"/>
    <dbReference type="OrthoDB" id="5324651at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU44867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="60598" checksum="E2C5436A2C335B00" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVC9</accession>
    <name>C7YVC9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_101749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050275.1">
        <property type="nucleotide sequence ID" value="XM_003050229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVC9"/>
    <dbReference type="STRING" id="660122.C7YVC9"/>
    <dbReference type="GeneID" id="9674703"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101749"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101749"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_347509_0_0_1"/>
    <dbReference type="InParanoid" id="C7YVC9"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="entry name" value="Peptidase C15, pyroglutamyl peptidase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="244"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU44562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="812" mass="92992" checksum="11BC60CC66DA38B5" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVI2</accession>
    <name>C7YVI2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-oxoadipate dioxygenase/decarboxylase</fullName>
            <ecNumber evidence="6">1.13.11.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-hydroxyglutarate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_48843</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 2-oxoadipate dioxygenase/decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.93" evidence="6"/>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050306.1">
        <property type="nucleotide sequence ID" value="XM_003050260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVI2"/>
    <dbReference type="GeneID" id="9675091"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_48843"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_48843"/>
    <dbReference type="eggNOG" id="ENOG502QV4Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026640_0_0_1"/>
    <dbReference type="InParanoid" id="C7YVI2"/>
    <dbReference type="OMA" id="FRWHETA"/>
    <dbReference type="OrthoDB" id="8300246at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16348">
        <property type="entry name" value="VOC_YdcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.80">
        <property type="entry name" value="Uncharacterised protein PF07063, DUF1338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009770">
        <property type="entry name" value="HGLS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047869">
        <property type="entry name" value="YdcJ_bac-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39479">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39479:SF2">
        <property type="entry name" value="2-OXOADIPATE DIOXYGENASE_DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07063">
        <property type="entry name" value="HGLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01150">
        <property type="entry name" value="DUF1338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU44593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="461" mass="51465" checksum="6A0964DFF57EC3CF" modified="2009-10-13" version="1">MDSHGSNSIFVDADELRTNFASAMSAMYRKEVPLYGDLVNIVRDVNTLILQKRQASDASTTSAAIRTSSERLTLERHGAIRLGTPYELQTVTRIFKILGMHPVGYYDLSLAGLPMHATCFRPTEVSSLDKNPFRVFTTLLRPELLASEEARKLSLTLLGGRKIFTDKLLGLLDRAESQGGRLDKYQAEVFIPQALFTFSWKPIAAATFSQYNLIKAEHPILADIACFQSSHINHLTPRTLDIDAVQEAMQRADMAVKSRIEGPPLRKCPILLRQTSFLALEEAVKFPTDGGKTEEALVEASHKARFGEIEERGAAVTAKGRELYDRLLSESREMAGDANPKEADAIVADTFRAYPDDWVQLRRQGLIFCEFRCVKKPAEKPKKEYTNVTLLEQLILDGVVQASPITYEDFLPFSAAGIFQSNLKNRTGEDSSLDLKPPSSDREGLEEAIQTKLLNADDWYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVP4</accession>
    <name>C7YVP4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_30021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049746.1">
        <property type="nucleotide sequence ID" value="XM_003049700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVP4"/>
    <dbReference type="STRING" id="660122.C7YVP4"/>
    <dbReference type="GeneID" id="9677321"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_30021"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_30021"/>
    <dbReference type="eggNOG" id="ENOG502RW59">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003953_5_1_1"/>
    <dbReference type="InParanoid" id="C7YVP4"/>
    <dbReference type="OMA" id="CETHLAR"/>
    <dbReference type="OrthoDB" id="5135333at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF12">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="172"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU44033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="518" mass="58803" checksum="E3491FC9D9DC02C5" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVR6</accession>
    <name>C7YVR6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_74051</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU43839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049552.1">
        <property type="nucleotide sequence ID" value="XM_003049506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVR6"/>
    <dbReference type="GeneID" id="9677127"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74051"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74051"/>
    <dbReference type="eggNOG" id="ENOG502RFFW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_352352_0_0_1"/>
    <dbReference type="InParanoid" id="C7YVR6"/>
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    <dbReference type="OrthoDB" id="5324692at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051644">
        <property type="entry name" value="TRAMP_AT-DNA-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543:SF2">
        <property type="entry name" value="AGAP013096-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="53"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="169"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="86"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU43839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="798" mass="91281" checksum="CB9D24D122B0BD19" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVV8</accession>
    <name>C7YVV8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_89639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU43856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049569.1">
        <property type="nucleotide sequence ID" value="XM_003049523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVV8"/>
    <dbReference type="GeneID" id="9677357"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89639"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89639"/>
    <dbReference type="eggNOG" id="ENOG502SJZR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044876_1_0_1"/>
    <dbReference type="InParanoid" id="C7YVV8"/>
    <dbReference type="OMA" id="VPCEFGS"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF7">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU43856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="292" mass="32698" checksum="133EC82F3303F73D" modified="2009-10-13" version="1">MSLQARKIAIVGGTGTVGSRTLTSLLDKNIHTITAISRNFLVSSLKGQDVLILQLNPMAMGVQESFIRAAAKAGVPYILPTEFGTDIEALDLTREQPIISGKKALRDLVEQLGVSSWIAVVNNLWFDWSLKMNCWGINVKERKAEIWNGGSIKANTSTLKRVGAAVAELLSRPEEELSAYKNKPFYVSSFFISQREMFESVQRVTGTTDADWEIKEKDIYEFGRECDERLQKGDMMAALEKLSSLLLRERLGGNYNHKVVDMERFGLQQEDLDEVVKGAVEPAQVTRTLLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWH0</accession>
    <name>C7YWH0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_29873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049891.1">
        <property type="nucleotide sequence ID" value="XM_003049845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWH0"/>
    <dbReference type="GeneID" id="9677489"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_29873"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_29873"/>
    <dbReference type="eggNOG" id="ENOG502T38E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102257_0_0_1"/>
    <dbReference type="InParanoid" id="C7YWH0"/>
    <dbReference type="OMA" id="SRRCYVE"/>
    <dbReference type="OrthoDB" id="4741350at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="47"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU44178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="220" mass="26364" checksum="03BC56D9B1AF504E" modified="2009-10-13" version="1">MTSRRFYVETSPEGRPQFVTVKRSRSYHHHRHSCDYYKVSREEWKTLVKQNQQLEEANQDFAAQNETLRVRLHNAEAETHRLCHVVIPQLRDQVEHLTAENECLRRSIDNSCDSTSRSHREMDALRAKVCRLEKENKTLKDENGDLRYRVCQLSKQIDQSLSRRVADLTKQIEYWTNQSGFWKKTYEELRERHIGLITVVESKTEKIEVYEDILKRRRVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWR9</accession>
    <name>C7YWR9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_101111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049422.1">
        <property type="nucleotide sequence ID" value="XM_003049376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWR9"/>
    <dbReference type="GeneID" id="9677058"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101111"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101111"/>
    <dbReference type="eggNOG" id="ENOG502SQUK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1138270_0_0_1"/>
    <dbReference type="InParanoid" id="C7YWR9"/>
    <dbReference type="OMA" id="HGSWVKF"/>
    <dbReference type="OrthoDB" id="4158987at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU43709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="244" mass="26702" checksum="DCEC9885B2D2079B" modified="2009-10-13" version="1">MIIQKQDSSSRSTNRMQRGECYVISPMSYNYRSEHYLFKPHSRIINPFRAPPVLRTPCIMEALISQVLNKSGEETKDQDGEQPSTKDKLTKEIQNRVDEASNLQGKSIQLHEQADEAEDPKVAEDLRFQARETDKKAAKLMKTAERLEAGWIQGGAFGTGIGAGIASGIGVTVGTLLTGVVAIPTSGLGMLIGAGTGLVHGPWVKFTEAFSKEEAESIVQDAQKEADNIIKSEKTEKPEKPDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7YY22</accession>
    <name>C7YY22_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extracellular serine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_45195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049149.1">
        <property type="nucleotide sequence ID" value="XM_003049103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YY22"/>
    <dbReference type="GeneID" id="9666537"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45195"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45195"/>
    <dbReference type="eggNOG" id="ENOG502QR2R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010712_1_0_1"/>
    <dbReference type="InParanoid" id="C7YY22"/>
    <dbReference type="OMA" id="LETHATW"/>
    <dbReference type="OrthoDB" id="2113314at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056825">
        <property type="entry name" value="Agd3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056826">
        <property type="entry name" value="Agd3_CE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056827">
        <property type="entry name" value="CBM87_Agd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050788">
        <property type="entry name" value="Yeast_SRP1/TIP1_CWP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31002:SF34">
        <property type="entry name" value="CELL WALL PROTEIN CWP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31002">
        <property type="entry name" value="SERIPAUPERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25117">
        <property type="entry name" value="Agd3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25115">
        <property type="entry name" value="Agd3_CE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25116">
        <property type="entry name" value="CBM87_Agd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Agd3 CBM87" evidence="2">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Agd3 deacetylase" evidence="1">
        <location>
            <begin position="224"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Agd3 C-terminal" evidence="3">
        <location>
            <begin position="593"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU43436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="664" mass="73344" checksum="91BEC19B217E2C19" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYH5</accession>
    <name>C7YYH5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="7 11">3.13.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_62736</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.13.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="10 11">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <dbReference type="EC" id="3.13.2.1" evidence="7 11"/>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048901.1">
        <property type="nucleotide sequence ID" value="XM_003048855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYH5"/>
    <dbReference type="FunCoup" id="C7YYH5">
        <property type="interactions" value="1018"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YYH5"/>
    <dbReference type="GeneID" id="9665493"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_62736"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_62736"/>
    <dbReference type="eggNOG" id="KOG1370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025194_2_1_1"/>
    <dbReference type="InParanoid" id="C7YYH5"/>
    <dbReference type="OMA" id="YIGVTVE"/>
    <dbReference type="OrthoDB" id="10007170at2759"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033353">
        <property type="term" value="P:S-adenosylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1480:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004005">
        <property type="entry name" value="PRK05476.2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF0">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="13">
        <location>
            <begin position="194"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="160"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="225"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="302"/>
            <end position="304"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU43188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="449" mass="48952" checksum="A26579D402DCF63F" modified="2009-10-13" version="1">MSAPAHKFKVADLSLAAFGRKEIELAENEMPGLMQTRAKYAADQPLAGARIAGCLHMTIQTAVLIETLTALGAEVTWTSCNIFSTQDHAAAAIAAAGVPVFAWKGETEEEYNWCLEQQLLAFKDDKKLNLILDDGGDLTTLVHNKYPEMLKDCYGVSEETTTGVHHLYRMLKESKLLVPAINVNDSVTKSKFDNLYGCRESLVDGIKRATDVMIAGKVAVVAGFGDVGKGCAMALHGMGARVLVTEIDPINALQAAMAGYQVTTMEKAAKIGQIFVTTTGCRDILTGVHFEAMPNDAIVCNIGHFDIEIDVAWLKANASSVQNIKPQVDRFLMPNGRHIILLAEGRLVNLGCATGHSSFVMSCSFTNQVLAQIMLFKASDKAWGEKYVEFAKTGKLDVGVYVLPKILDEEVARLHLDHCQAELSTLTQVQADYLGLTREGPFKADIYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZ60</accession>
    <name>C7YZ60_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_105094</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003048788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZ60"/>
    <dbReference type="FunCoup" id="C7YZ60">
        <property type="interactions" value="1751"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YZ60"/>
    <dbReference type="GeneID" id="9666095"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_105094"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_105094"/>
    <dbReference type="eggNOG" id="KOG2294">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007090_1_0_1"/>
    <dbReference type="InParanoid" id="C7YZ60"/>
    <dbReference type="OMA" id="EKYAFYR"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22701">
        <property type="entry name" value="FHA_FKH1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000030">
        <property type="entry name" value="Forkhead box protein K2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF1">
        <property type="entry name" value="FORK HEAD PROTEIN HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="106"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Fork-head" evidence="9">
        <location>
            <begin position="282"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="282"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="218"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="375"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="533"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="504"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU43121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="617" mass="66814" checksum="0D2FFB323B2FDDB7" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZG3</accession>
    <name>C7YZG3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Involucrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_63053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048512.1">
        <property type="nucleotide sequence ID" value="XM_003048466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZG3"/>
    <dbReference type="STRING" id="660122.C7YZG3"/>
    <dbReference type="GeneID" id="9667589"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_63053"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_63053"/>
    <dbReference type="eggNOG" id="ENOG502S9Q7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019744_2_0_1"/>
    <dbReference type="InParanoid" id="C7YZG3"/>
    <dbReference type="OMA" id="DENGGHM"/>
    <dbReference type="OrthoDB" id="5328813at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="53397" checksum="14258F92368D3D94" modified="2009-10-13" version="1">MNTSEKRRPGPGNSSAHTLRTGVSNPNRNSMPALPPRAAMAANTVSSPEENIEGGAPLTERKEKDATATRSGSIKDKDREKERKERREKKEKKERERELEAALKDKDERIAYLEKEMGIMEREFHRELDKLSQNESETATFWQAKHSALNQQFLRTDTELRLLRAEVEVREGEREELREGWEVLRRELKERDNEIRGLRGQVRGLKEWVSNSTRTDGQTCDEVFGDGMARLGNGLQNWVIVNFRKAKIRLDELDEATLAEINDLVPMYEDLASTAKVHLLQSIVSRILVEMVFDAYFVGLSSEQTQQFRQMEKMLYSYASSDEAINQWRSSTLALLRRDSTVLDESISSLTEAVLARITRILDALCGTSPSEARDSGLRVLVNNSIELARLLVVQKAVLRVHMPAVLPHQRVMFEPETMEDLGGEDEEALAEREICCVAFPGVIKHGDENGGHLQFRNIIVKARVLCSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZW9</accession>
    <name>C7YZW9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_105167</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048582.1">
        <property type="nucleotide sequence ID" value="XM_003048536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZW9"/>
    <dbReference type="FunCoup" id="C7YZW9">
        <property type="interactions" value="1140"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YZW9"/>
    <dbReference type="GeneID" id="9667474"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_105167"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_105167"/>
    <dbReference type="eggNOG" id="KOG3424">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107248_1_0_1"/>
    <dbReference type="InParanoid" id="C7YZW9"/>
    <dbReference type="OMA" id="IRVKKYM"/>
    <dbReference type="OrthoDB" id="5571754at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3370:FF:000001">
        <property type="entry name" value="40S ribosomal protein S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053709">
        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018098">
        <property type="entry name" value="Ribosomal_eS24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00529">
        <property type="entry name" value="RIBOSOMAL_S24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="102"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU42869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="136" mass="15486" checksum="A9B1E3577591FA29" modified="2009-10-13" version="1">MADNDSPVTLRTRKFIRNPLLGRKQMVVDILHPNRANISKDELREKLGGLYKAQKDQISVFGLRTQYGGGKTTGFALVYDSPEAMKKFEPQYRLVRVGLATKAERASRQQRKQRKNRQKTLRGTAKVKGAKAKKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0H0</accession>
    <name>C7Z0H0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial transcription factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_60662</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial transcription factor that confers selective promoter recognition on the core subunit of the yeast mitochondrial RNA polymerase. Interacts with DNA in a non-specific manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047914.1">
        <property type="nucleotide sequence ID" value="XM_003047868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0H0"/>
    <dbReference type="GeneID" id="9671899"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_60662"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_60662"/>
    <dbReference type="eggNOG" id="ENOG502QY7G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014537_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z0H0"/>
    <dbReference type="OMA" id="VDILDLW"/>
    <dbReference type="OrthoDB" id="16079at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034245">
        <property type="term" value="C:mitochondrial DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034246">
        <property type="term" value="F:mitochondrial transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006391">
        <property type="term" value="P:transcription initiation at mitochondrial promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="entry name" value="Ribosomal RNA adenine dimethylase-like, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF17">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="541"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="555"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU42201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="566" mass="64468" checksum="FE8406177EE288F7" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0M1</accession>
    <name>C7Z0M1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_93241</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048120.1">
        <property type="nucleotide sequence ID" value="XM_003048074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0M1"/>
    <dbReference type="GeneID" id="9671923"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_93241"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_93241"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_43_5_1"/>
    <dbReference type="InParanoid" id="C7Z0M1"/>
    <dbReference type="OMA" id="WVPETMQ"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000474">
        <property type="entry name" value="Sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF40">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="482"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="95"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU42407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="603" mass="67662" checksum="2114627AD49EBDC2" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z180</accession>
    <name>C7Z180_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">NECHADRAFT_100421</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048239.1">
        <property type="nucleotide sequence ID" value="XM_003048193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z180"/>
    <dbReference type="FunCoup" id="C7Z180">
        <property type="interactions" value="1460"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z180"/>
    <dbReference type="GeneID" id="9671843"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100421"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100421"/>
    <dbReference type="eggNOG" id="KOG0925">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_5_11_1"/>
    <dbReference type="InParanoid" id="C7Z180"/>
    <dbReference type="OMA" id="MKVYPLY"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17973">
        <property type="entry name" value="DEXHc_DHX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000324">
        <property type="entry name" value="pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000003">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044756">
        <property type="entry name" value="DHX15_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF109">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="111"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="298"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEU42526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="768" mass="86770" checksum="AC749B88F568CF98" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1P9</accession>
    <name>C7Z1P9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_85874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU42037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047750.1">
        <property type="nucleotide sequence ID" value="XM_003047704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1P9"/>
    <dbReference type="STRING" id="660122.C7Z1P9"/>
    <dbReference type="GeneID" id="9671535"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85874"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85874"/>
    <dbReference type="eggNOG" id="ENOG502QS87">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023635_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z1P9"/>
    <dbReference type="OMA" id="WHHAQAS"/>
    <dbReference type="OrthoDB" id="4898142at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="607" mass="67410" checksum="3929CCD6FE6FDD74" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1V7</accession>
    <name>C7Z1V7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial intermembrane space import and assembly protein 40</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase TIM40</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_50847</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU41892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047605.1">
        <property type="nucleotide sequence ID" value="XM_003047559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1V7"/>
    <dbReference type="STRING" id="660122.C7Z1V7"/>
    <dbReference type="GeneID" id="9671740"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_50847"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_50847"/>
    <dbReference type="eggNOG" id="KOG4149">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054990_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z1V7"/>
    <dbReference type="OMA" id="AYATHAP"/>
    <dbReference type="OrthoDB" id="7481291at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039289">
        <property type="entry name" value="CHCHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622:SF0">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="95"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="202"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU41892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="262" mass="28565" checksum="4C023CE5060B8BD4" modified="2009-10-13" version="1">MYLKTLRSASRPAVTNLRSIALQRFTSTAARRRPTRSWKSSAVQLSLAVGAFYYFNTSPVFAEATAQTIPTPTRSDDNPSKDLIAEKQRQINANTETTHENDPESAKNPEPQSGAQSGIATNDAANPEDKSQQGAFNPETGEFNWDCSCLGGMAHGPCGEEFKSSFSCFMLSTDEPKGMNCIEHFKVMQECFKKYPDVYGGELTDDAEGDPAPNLDDEQPDASSVPMKAQSTTPVEAGAASKEPERARKNEGPKKKVNAERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z268</accession>
    <name>C7Z268_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Lysophospholipase</fullName>
            <ecNumber evidence="2 10">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_105559</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the lysophospholipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="2 10"/>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU41951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047664.1">
        <property type="nucleotide sequence ID" value="XM_003047618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z268"/>
    <dbReference type="FunCoup" id="C7Z268">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z268"/>
    <dbReference type="GeneID" id="9671799"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_105559"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_105559"/>
    <dbReference type="eggNOG" id="KOG1325">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014602_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z268"/>
    <dbReference type="OMA" id="GPEQYSL"/>
    <dbReference type="OrthoDB" id="4084751at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000010">
        <property type="entry name" value="Lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF33">
        <property type="entry name" value="LYSOPHOSPHOLIPASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 9 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005125811" description="Lysophospholipase" evidence="10">
        <location>
            <begin position="24"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="PLA2c" evidence="11">
        <location>
            <begin position="64"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU41951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="654" mass="70938" checksum="3A904B19FACD8374" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z372</accession>
    <name>C7Z372_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_87850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047496.1">
        <property type="nucleotide sequence ID" value="XM_003047450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z372"/>
    <dbReference type="GeneID" id="9675929"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87850"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87850"/>
    <dbReference type="eggNOG" id="ENOG502S16A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020223_2_0_1"/>
    <dbReference type="InParanoid" id="C7Z372"/>
    <dbReference type="OMA" id="FSWHIFG"/>
    <dbReference type="OrthoDB" id="2283488at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="63"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU41783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="554" mass="61798" checksum="FDF76F45664B6DD1" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z3A8</accession>
    <name>C7Z3A8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycosyl hydrolase family 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_6183</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047337.1">
        <property type="nucleotide sequence ID" value="XM_003047291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z3A8"/>
    <dbReference type="STRING" id="660122.C7Z3A8"/>
    <dbReference type="GeneID" id="9675948"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_6183"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_6183"/>
    <dbReference type="eggNOG" id="ENOG502QW2A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016116_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z3A8"/>
    <dbReference type="OMA" id="NDSRDMT"/>
    <dbReference type="OrthoDB" id="9970295at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18821">
        <property type="entry name" value="GH43_Pc3Gal43A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22925">
        <property type="entry name" value="GLYCOSYL HYDROLASE 43 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22925:SF3">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU41624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="31653" checksum="E3009AC61BDDAE17" modified="2009-10-13" version="1" fragment="single">IQNFSGATWTASNGHHIQAHGGGFLKVGATWYWHGEDKTEGTCFQNINCYSSNDLVQWKYEGPVLSRQGSGDLGPGRLVERPKVIYNKLTKKYVMWMHIEDQEYKDAKVGVATCDTVTGRFQYRGSFRPLGFESRDIGVFVDDDDKAYLMSEDRPNGLRFYELSNDYLSVTKMLHLFPEHLESPAMIKRNGIYYLLASQLTGWELNDNMYTTATSLTGPWEPWKLFAESGTATYGSQVTFVLDLGSSVLYMGDRWEYPPLPRSTYVWLPLSINDRAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z3F3</accession>
    <name>C7Z3F3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_26479</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047013.1">
        <property type="nucleotide sequence ID" value="XM_003046967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z3F3"/>
    <dbReference type="STRING" id="660122.C7Z3F3"/>
    <dbReference type="GeneID" id="9675348"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_26479"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_26479"/>
    <dbReference type="eggNOG" id="ENOG502SIFD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_12_4_1"/>
    <dbReference type="InParanoid" id="C7Z3F3"/>
    <dbReference type="OMA" id="CDIAIFL"/>
    <dbReference type="OrthoDB" id="4682787at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="44"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="341"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU41300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="372" mass="41108" checksum="7EE5167D94420AD4" modified="2009-10-13" version="1" fragment="single">LDGPAMPPPEGEVSNFTDPPNQNGMAVAVMTVCIAVVVLCLATRAYARLVLLKRAQAQEYLILAAFGCFVGWSYCTMSLVPSPGFYVHTWNVRLGQTVMMELTTTRQHVHLAGVFYSVCLPLLKISIMVEWLGIFSSPGTRNWFFWVSWIMISVQVAFAIAAVIALNLACIPTKKKWEFWLPGKCINAHDIETVSAAFQLISDCIVLLLPQKVIWDLRLSWKKKLGVSIIFSLGILACVSAAFRLAGTVQYAEAVDSIYNIGPVCFWAYAEMTCGFIVVCVPCVPKILMESGVWRKMKKGFGQSVTATSKSQSGATTGRSQNIRSVNNSYTEIDETELKDFRSESTEHLRHAPAKVEQGIKRTTQVTVTQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z3Y7</accession>
    <name>C7Z3Y7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_46331</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2"/>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047099.1">
        <property type="nucleotide sequence ID" value="XM_003047053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z3Y7"/>
    <dbReference type="FunCoup" id="C7Z3Y7">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z3Y7"/>
    <dbReference type="GeneID" id="9675584"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_46331"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_46331"/>
    <dbReference type="eggNOG" id="KOG4534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_511984_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z3Y7"/>
    <dbReference type="OMA" id="DQLWVGQ"/>
    <dbReference type="OrthoDB" id="3361892at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032931">
        <property type="term" value="F:histone H3K56 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013178">
        <property type="entry name" value="Histone_AcTrfase_Rtt109/CBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016849">
        <property type="entry name" value="Rtt109"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF2">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE RTT109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08214">
        <property type="entry name" value="HAT_KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01250">
        <property type="entry name" value="KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51728">
        <property type="entry name" value="RTT109_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="320"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU41386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="536" mass="60539" checksum="DEB610937E08E547" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-31" modified="2025-04-09" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z403</accession>
    <name>LCL2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName>Long chronological lifespan protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">LCL2</name>
        <name type="ORF">NECHADRAFT_83432</name>
    </gene>
    <organism>
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable component of the endoplasmic reticulum-associated degradation (ERAD) pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LCL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047109.1">
        <property type="nucleotide sequence ID" value="XM_003047063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z403"/>
    <dbReference type="STRING" id="660122.C7Z403"/>
    <dbReference type="EnsemblFungi" id="NechaT83432">
        <property type="protein sequence ID" value="NechaP83432"/>
        <property type="gene ID" value="NechaG83432"/>
    </dbReference>
    <dbReference type="GeneID" id="9678682"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83432"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83432"/>
    <dbReference type="eggNOG" id="ENOG502S416">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142363_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z403"/>
    <dbReference type="OMA" id="DNYLCPD"/>
    <dbReference type="OrthoDB" id="2234316at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23996">
        <property type="entry name" value="LCL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034543">
        <property type="entry name" value="LCL2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38425">
        <property type="entry name" value="LONG CHRONOLOGICAL LIFESPAN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38425:SF1">
        <property type="entry name" value="LONG CHRONOLOGICAL LIFESPAN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000408613" description="Long chronological lifespan protein 2">
        <location>
            <begin position="17"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="119" mass="13493" checksum="61714E9519740A70" modified="2009-10-13" version="1" precursor="true">MRYLIAILSLLSLANAQFGGFFDQMFGQQGGHEQHHGQPQNNPSDASHYRHQYDNSVCDKYLCPDTLACVHFPHHCPCAWDAQQEKFELAEGQRMCVSRGGFREGETARKLELARKGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z412</accession>
    <name>C7Z412_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Succinate dehydrogenase cytochrome b subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_70858</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047113.1">
        <property type="nucleotide sequence ID" value="XM_003047067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z412"/>
    <dbReference type="FunCoup" id="C7Z412">
        <property type="interactions" value="395"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z412"/>
    <dbReference type="GeneID" id="9675284"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_70858"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_70858"/>
    <dbReference type="eggNOG" id="KOG0449">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094691_0_1_1"/>
    <dbReference type="InParanoid" id="C7Z412"/>
    <dbReference type="OMA" id="MNGIRHL"/>
    <dbReference type="OrthoDB" id="588261at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU41400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="20146" checksum="ADFB99AB3FCD23D0" modified="2009-10-13" version="1">MLAQRVGVAALRRGAAKPSSVFFSQTLPKVALTAGISTTPSRPVASTKLSQEEGRQLLVNQRLNRPVSPHLGIYKMEQTWFGSSAWNRITGCTLSATMYAFMGAYLVAPVVGLHLETASVAAAFGGLPLVVKGGVKLALGFPFVYHLINGFKHLLYDMGKGFAKPTIKKTDNILWAASILGAIGLVAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4H2</accession>
    <name>C7Z4H2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_76520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046059.1">
        <property type="nucleotide sequence ID" value="XM_003046013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4H2"/>
    <dbReference type="GeneID" id="9668422"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76520"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76520"/>
    <dbReference type="eggNOG" id="ENOG502SSS7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057547_4_1_1"/>
    <dbReference type="InParanoid" id="C7Z4H2"/>
    <dbReference type="OMA" id="CYYRIRS"/>
    <dbReference type="OrthoDB" id="4500473at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU40346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="282" mass="30671" checksum="188EEE4BEAE8126B" modified="2009-10-13" version="1">MGKKELLAYIRAPNLDYEPDKAIRLGHIWRNPRDPGSFCGQPLAIPRGMETNHTYKAPWFIGKGRSTRGSVGVWAKFLQVVGVTAQANFNWNNADDMAHTFQRLDTYSIEPTPEYLKASIEAVAEDAIKKGERLYMITGVKVARGAVGTIFSSRTVGARGRVGASGASQGVDAEGGPYFDASRNEYSGVSYGESSDFVFAYRVREILYRKGDYKTRVGDHTDAMYAGAGVPLAVDVGARAGDFAICVGNAELESVDVGFDDEFSDGAMLFIDDDGEECLFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4I6</accession>
    <name>C7Z4I6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_66520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046067.1">
        <property type="nucleotide sequence ID" value="XM_003046021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4I6"/>
    <dbReference type="FunCoup" id="C7Z4I6">
        <property type="interactions" value="311"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z4I6"/>
    <dbReference type="GeneID" id="9678173"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_66520"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_66520"/>
    <dbReference type="eggNOG" id="KOG0873">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047036_5_0_1"/>
    <dbReference type="InParanoid" id="C7Z4I6"/>
    <dbReference type="OMA" id="IVHEFIY"/>
    <dbReference type="OrthoDB" id="1658724at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="5">
        <location>
            <begin position="144"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU40354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="305" mass="35910" checksum="C05B3FA80AF0F964" modified="2009-10-13" version="1">MDMLNTTMKSFNQTNDYFVVLEEVSKYNVQLNFLEKLWAAWYLWMQNDTLATGIMSFVLHELVYFGRCVPYMIMDFIPFFNRYKIQSQKIPTLKEQWDCAAIVLVSHFTAELPQIWFFHPIATYLGMDYNVPFPPVWKMAYQIAICFIMEDAWHYWFHRGLHYGPLYKAIHKMHHTYSAPFGLAAEYASPIETALLGIGVVGCPIVLLKVTGELHLFTMYVWIILRLFQAIDAHSGYDFPWSLRHFLPFWAGAEHHDLHHEKFIGNYASSFRWWDFCLDTEAGAEAHKRRREKKLAAIKAQKKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4W7</accession>
    <name>C7Z4W7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Nicotinate-nucleotide pyrophosphorylase [carboxylating]</fullName>
            <ecNumber evidence="5 12">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NECHADRAFT_91202</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Hexamer formed by 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NadC/ModD family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="5 12"/>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046132.1">
        <property type="nucleotide sequence ID" value="XM_003046086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4W7"/>
    <dbReference type="FunCoup" id="C7Z4W7">
        <property type="interactions" value="279"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z4W7"/>
    <dbReference type="GeneID" id="9678514"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_91202"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_91202"/>
    <dbReference type="eggNOG" id="KOG3008">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039622_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z4W7"/>
    <dbReference type="OMA" id="DIVMCDN"/>
    <dbReference type="OrthoDB" id="10067394at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034213">
        <property type="term" value="P:quinolinate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000090">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.20:FF:000003">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="entry name" value="Quinolinate phosphoribosyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179:SF3">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase N-terminal" evidence="14">
        <location>
            <begin position="39"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase C-terminal" evidence="13">
        <location>
            <begin position="118"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU40419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="296" mass="31903" checksum="098D86383ED1A9C0" modified="2009-10-13" version="1">MAQPQGNLANLLPPSWKTSVTAWLAEDTPSFDYAGFVVGDEPRVATLWGKSAGVIAGRPFFDEVFTQCGCTVEWHADEATAVDLSNGKHRVATVKGPVRGILLGERVALNTLARCSGIATKSQRLVMIARKAGYKGVIAGTRKTTPGFRLVEKYGMLVGGADAHRMDLSAMVMLKDNHVWSRGSITDAVKAAKSVAGFSMKVEVEVQSEAEADEAIEAGADVVMLDNFTGDGVKVAAQSLKQRWQGKRHFLLEVSGGLQEDNFEAYLCNEADVDILSTSSIHQGVPHIDFSLKIEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z599</accession>
    <name>C7Z599_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavin-nucleotide-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_91296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU41061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046774.1">
        <property type="nucleotide sequence ID" value="XM_003046728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z599"/>
    <dbReference type="STRING" id="660122.C7Z599"/>
    <dbReference type="GeneID" id="9678305"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_91296"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_91296"/>
    <dbReference type="eggNOG" id="ENOG502S42E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067890_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z599"/>
    <dbReference type="OMA" id="CHLGFVR"/>
    <dbReference type="OrthoDB" id="444432at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34071">
        <property type="entry name" value="5-NITROIMIDAZOLE ANTIBIOTICS RESISTANCE PROTEIN, NIMA-FAMILY-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34071:SF2">
        <property type="entry name" value="FLAVIN-NUCLEOTIDE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU41061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="28689" checksum="A44463B093CCDCA1" modified="2009-10-13" version="1">MGRYDLEYPKEAINTIKRENDRAVYALKTIHEIVNSCQILHVSFNTPSQPFPVILPMIGQMGSFERPSADIGDPLDLYLHGYVSSRIMNLGRGAEEGMPVCVAASHVDGLVLALSSFSHSYNYRSTVLFGHASLVNDEEERMYAMELITNSVVPDRWRHTRLPPTKAELQSTGILKVRIASGSAKIRTGGAHDERHDMENQDLQDKVWTGVVPVQQTMGEPVPSTYNRIDVPGYMSEFIKDFNTDNTQYALDVTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6S9</accession>
    <name>C7Z6S9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_90823</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the proteasome inhibitor PI31 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046462.1">
        <property type="nucleotide sequence ID" value="XM_003046416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6S9"/>
    <dbReference type="STRING" id="660122.C7Z6S9"/>
    <dbReference type="GeneID" id="9668804"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90823"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90823"/>
    <dbReference type="eggNOG" id="ENOG502SE4N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044125_2_0_1"/>
    <dbReference type="InParanoid" id="C7Z6S9"/>
    <dbReference type="OMA" id="GHACMVA"/>
    <dbReference type="OrthoDB" id="68090at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045128">
        <property type="entry name" value="PI31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013886">
        <property type="entry name" value="PI31_Prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021625">
        <property type="entry name" value="PI31_Prot_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266">
        <property type="entry name" value="PROTEASOME INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266:SF1">
        <property type="entry name" value="PROTEASOME INHIBITOR PI31 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08577">
        <property type="entry name" value="PI31_Prot_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11566">
        <property type="entry name" value="PI31_Prot_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI31 proteasome regulator N-terminal" evidence="13">
        <location>
            <begin position="27"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="PI31 proteasome regulator C-terminal" evidence="12">
        <location>
            <begin position="275"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="194"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="298"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU40749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="375" mass="40139" checksum="C55A3D1154FDA132" modified="2009-10-13" version="1">MAEPLSVGSILAGMAEALPTHPTGDDSSDLASSYEAIALLIHAYLAALGFKLHGFDEDKKLPECESLAPRLPQQWNSGFGSLSFVYTHKQSSMKFVVRVDRMGGKVEIRGLAVGDEHIYRFERSVRDVVQSSGLPVRITVNDGEEDRSDLAEKLRGVFVSEQAIVDILHDLKVNIVQKLIPKLQSEGYVETAEAEANARSERRAQEARDPNRPFRGDPAPNMDVRPPPANPLPEMARMEPRPVADFPPPGFEDEYEVNRPRRNPLAVPGRSPYNIGHDDLNPPGLGPHDPLRGSFIGGGLPRPGGGSGMHPTFDDPLFGGYGGDGSGGYDPQAPPGARWDPTGPGGNPRFPGPGGRGNNPYGGGFGGGFGGGDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6W6</accession>
    <name>C7Z6W6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_76234</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046481.1">
        <property type="nucleotide sequence ID" value="XM_003046435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6W6"/>
    <dbReference type="STRING" id="660122.C7Z6W6"/>
    <dbReference type="GeneID" id="9668822"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76234"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76234"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_3_2_1"/>
    <dbReference type="InParanoid" id="C7Z6W6"/>
    <dbReference type="OMA" id="WGMSIQW"/>
    <dbReference type="OrthoDB" id="47494at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="120"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU40768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="408" mass="45380" checksum="D2FDB04C25DC8219" modified="2009-10-13" version="1">MPDKDLHVIIIGAGITGLIVAQGLKRRQLGIRYSIFEKEVCLNYRSNEWTMAIHWALDRLENIVPPEVFSQIPLISCNPAVPVEAGGLYPIIQAETGNLLTGVPYEKGLRVSRSRMRALCAEGIEVQYGKNLIDVAFNESGQGVVASFSDGTVVSGSIIVGADGPRSKVREFAMGSAEEAAVSKFPIFHTNMTVCYNDAEKAKYVRRDYPTSFLALSNQSFHAFQSISNMPDGQDHPESWIFHMAMAWMGDSNHKLSYPERLALLKERAAGMGEPARSAFLWLPEDTEVHKADISYWITKPWNNHGGRMTLIGDAAHPMPPYRGQGLNHCICDTSYLITGLEGVFRGETELEDAIKIYEADVIPRGQEEVKCSVENGYMLHDWKKVEASPVFTRGFKPMEGHDSKPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7U1</accession>
    <name>C7Z7U1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_60536</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045462.1">
        <property type="nucleotide sequence ID" value="XM_003045416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7U1"/>
    <dbReference type="GeneID" id="9672499"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_60536"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_60536"/>
    <dbReference type="eggNOG" id="KOG2615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_54_6_1"/>
    <dbReference type="InParanoid" id="C7Z7U1"/>
    <dbReference type="OMA" id="IWQMILF"/>
    <dbReference type="OrthoDB" id="419616at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="473"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="70"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU39749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="515" mass="55282" checksum="71DA86D2BD6D61F7" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7W3</accession>
    <name>C7Z7W3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_100289</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045474.1">
        <property type="nucleotide sequence ID" value="XM_003045428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7W3"/>
    <dbReference type="GeneID" id="9672509"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100289"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100289"/>
    <dbReference type="eggNOG" id="ENOG502SQ99">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011409_2_1_1"/>
    <dbReference type="InParanoid" id="C7Z7W3"/>
    <dbReference type="OMA" id="QMEYLLR"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="120"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU39761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="685" mass="76503" checksum="3F3159E6239729A4" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7Z6</accession>
    <name>C7Z7Z6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_79612</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045625.1">
        <property type="nucleotide sequence ID" value="XM_003045579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7Z6"/>
    <dbReference type="GeneID" id="9672525"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79612"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79612"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="C7Z7Z6"/>
    <dbReference type="OMA" id="NIHEACG"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF48">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="60"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="479"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU39912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="510" mass="56903" checksum="F303614EB1238826" modified="2009-10-13" version="1">MTGLTETRDNPIPITSADSVTKVEAGDELSHMEDQKNVPPEFIFDRQAERRLRNKIDLTIMPIICLMYLFCFIDRANIGNARIAGMDVDLGMKGFDYNVILSMFYVSYIIFELPSNIVCKILGPGWFLPALTVLFGACSIGSGFVKTVPQMMGVRFLLGIFEAGMLPGIAYYLSRWYRRSELTFRLGLYLVAGPLAGAFGALLASAILRLDHFGSVDSWRMIFVIEGIITVGLGLIGFVTMTDRPGTARWLTEAEKQLSEDRVRSERVGQAKVLDKMDKKKLILGIWNPVVISTSWIFLFCNVTVQGLGFFLPTIVRTIYTDYTVIKQQLYTVPPYAVGSVVTLLLPLISWRFDRRQLIMILTTPLCIAGYVIFLSTANQSARYGATFLVASSVFSLGALTNSQVSANVVSDTARSSAIGLNVMLGNIGGLISTWSFLPFDGPNYPIGNGLNLATQVATLILATLTLLWMNRDNKRRERVESEELERVQAMSAEEQEDLDWKHPSFRWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z930</accession>
    <name>C7Z930_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_42899</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU38950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044663.1">
        <property type="nucleotide sequence ID" value="XM_003044617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z930"/>
    <dbReference type="FunCoup" id="C7Z930">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z930"/>
    <dbReference type="GeneID" id="9673072"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_42899"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_42899"/>
    <dbReference type="eggNOG" id="KOG1842">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026440_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z930"/>
    <dbReference type="OMA" id="DDVHQNL"/>
    <dbReference type="OrthoDB" id="166134at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15761">
        <property type="entry name" value="FYVE1_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15737">
        <property type="entry name" value="FYVE2_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.20">
        <property type="entry name" value="Rabenosyn, Rab binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021565">
        <property type="entry name" value="Rbsn_Rab-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036531">
        <property type="entry name" value="Rbsn_Rab-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164:SF29">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11464">
        <property type="entry name" value="Rbsn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140125">
        <property type="entry name" value="Rabenosyn-5 Rab-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="187"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="329"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="572"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="591"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="579"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU38950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="668" mass="73708" checksum="872D26D7AE4E3EC3" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9N9</accession>
    <name>C7Z9N9_FUSV7</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_94525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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            <taxon>Fusarium vanettenii</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045247.1">
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    </dbReference>
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    <dbReference type="STRING" id="660122.C7Z9N9"/>
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    <dbReference type="KEGG" id="nhe:NECHADRAFT_94525"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94525"/>
    <dbReference type="eggNOG" id="ENOG502S5WH">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094649_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z9N9"/>
    <dbReference type="OMA" id="SFWWLRS"/>
    <dbReference type="OrthoDB" id="5565730at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 213 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU39534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="215" mass="23301" checksum="07DF1F598A5CB8D7" modified="2009-10-13" version="1">MADKSSRDPQTAPLRQRQSSRGLFAPEIVDLVLPPLKVGGLTGTAGVLAGVGGSIFKEANPIIWGAVSGFQWFTLGTSFWFTRSIVVKAWGGEEQLRNSDKTKASAIAGTAAGAMGGLIRGPSNILPAMLVWTVLGAGGQMAVNRMSSRQPKVQDENTSWISRWSPLKKLTDEEYTNMMSEKMLRIDADIALIDDRIAELRKQAQEEAQADTPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZA65</accession>
    <name>C7ZA65_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_62268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044933.1">
        <property type="nucleotide sequence ID" value="XM_003044887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZA65"/>
    <dbReference type="STRING" id="660122.C7ZA65"/>
    <dbReference type="GeneID" id="9672115"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_62268"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_62268"/>
    <dbReference type="eggNOG" id="ENOG502S1AV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047439_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZA65"/>
    <dbReference type="OMA" id="MQAHAGK"/>
    <dbReference type="OrthoDB" id="5230543at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="264"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU39220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="309" mass="34617" checksum="BBF6EBE6EF6BE250" modified="2009-10-13" version="1">MNGMNGTNMAAGMPVPTPAGHQAELNYIYGMVEELSRQLAENRRVTEDIVSGLGRVRNRARTHGVNNQQVIEGASDDINGQEQNIDALISLLTESLEKAKFSRDANAKLLSQYASAMANLLRQFHEYKTKHVSDVASWHRSYRKQLSDARDENARLREQIWQMQAHAGRANESLREFRCKYDEDEARWNRLVDEKAVRQELRFWKRMAMPELEDDDPYWSDDDDIIDPAEKDRLRELDLKAAQEQLDSQAEDSDGQGPPPQLPLPGMGIGMSMMGGIAMQREDSAAGHGVPVLPPRPLSAASSTGSTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAI6</accession>
    <name>C7ZAI6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_82110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045397.1">
        <property type="nucleotide sequence ID" value="XM_003045351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAI6"/>
    <dbReference type="GeneID" id="9672176"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82110"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82110"/>
    <dbReference type="eggNOG" id="ENOG502RA0P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_350244_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZAI6"/>
    <dbReference type="OMA" id="NCDDGDI"/>
    <dbReference type="OrthoDB" id="5106870at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="593"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="804" mass="87991" checksum="67813DD8E7045C23" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAL6</accession>
    <name>C7ZAL6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_42966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045008.1">
        <property type="nucleotide sequence ID" value="XM_003044962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAL6"/>
    <dbReference type="STRING" id="660122.C7ZAL6"/>
    <dbReference type="GeneID" id="9672368"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_42966"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_42966"/>
    <dbReference type="eggNOG" id="KOG1211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_15_0_1"/>
    <dbReference type="InParanoid" id="C7ZAL6"/>
    <dbReference type="OMA" id="EIDMCQL"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005127">
        <property type="entry name" value="PRK06565.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF11">
        <property type="entry name" value="AMIDASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="45"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="680" mass="73346" checksum="236B6FBCF38871A6" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZB37</accession>
    <name>C7ZB37_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_101154</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044577.1">
        <property type="nucleotide sequence ID" value="XM_003044531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZB37"/>
    <dbReference type="STRING" id="660122.C7ZB37"/>
    <dbReference type="GeneID" id="9672759"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101154"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101154"/>
    <dbReference type="eggNOG" id="KOG4231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_325995_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZB37"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055481">
        <property type="entry name" value="DUF7053"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23155">
        <property type="entry name" value="DUF7053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="5">
        <location>
            <begin position="182"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7053" evidence="6">
        <location>
            <begin position="697"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="670"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="813"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="819"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU38864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="884" mass="99531" checksum="58DB7286868223E3" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZB44</accession>
    <name>C7ZB44_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_83201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044582.1">
        <property type="nucleotide sequence ID" value="XM_003044536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZB44"/>
    <dbReference type="STRING" id="660122.C7ZB44"/>
    <dbReference type="GeneID" id="9670776"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83201"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83201"/>
    <dbReference type="HOGENOM" id="CLU_064241_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZB44"/>
    <dbReference type="OrthoDB" id="6220758at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="21"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="303" mass="32770" checksum="94556E344142B11C" modified="2009-10-13" version="1">MTPSARDANFNEEALSRLCKAIQDDIDNGRMFAASIIVGRGGNIGLQKVFGTVTPDGRAACDDDIYLAMSVSKSFTAALILRAVDQGRFTLDTKVADILPDFAIGGKQNVTIRQLLNHTAGTFRGFLPPGISAENLGNLDQYYASVASIPIDYAVLGKILVATDPKERNFRTIAKEELFDPLGMEHSCFGLAEDHENRVPNHTGSLSKDALVPEKEARNMPDSPALYSLLGGYVRGDGHYLTGAGYTASPRAFYGVGGGSTMWMVDPDRDLTVCFFSAGFIEGLHHLERLSKINDVALSACNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBQ3</accession>
    <name>C7ZBQ3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_88491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698915">
        <property type="protein sequence ID" value="EEU38557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044270.1">
        <property type="nucleotide sequence ID" value="XM_003044224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBQ3"/>
    <dbReference type="GeneID" id="9670686"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88491"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88491"/>
    <dbReference type="eggNOG" id="ENOG502TBR9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089001_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZBQ3"/>
    <dbReference type="OMA" id="SVHYRHG"/>
    <dbReference type="OrthoDB" id="5152119at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU38557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="299" mass="35449" checksum="874CBC78787FD324" modified="2009-10-13" version="1">MEDEFKGLHQPGRLNELWEQLQNAQEVMMALRSRELEPGPLGYMEMLELLDQPSVAAFAALPEEARSKKWEELFEECDGSFLDDFFLYEVSHFEFLHSFKVLDRHIGHGKMERRLIQEARHFFYQRTEFVFSADWIGKFLADQLGQWDDAVPVEELVRRVIIRVDRRRMDGSKIAQYLRRSLEFTNIESLKVEIWAKGALDGSDYETQDTIRKMAGAVQELIDKFEDRFSIWKMRLEEEEMNGWRDDYIGEPYNITAWWDGPPIESWTRLKQGTASFQELMQDQIKSWKDWHGSDDDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCB1</accession>
    <name>C7ZCB1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_34482</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698918">
        <property type="protein sequence ID" value="EEU38341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044054.1">
        <property type="nucleotide sequence ID" value="XM_003044008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCB1"/>
    <dbReference type="STRING" id="660122.C7ZCB1"/>
    <dbReference type="GeneID" id="9670463"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_34482"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_34482"/>
    <dbReference type="eggNOG" id="ENOG502SJ8Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004804_0_2_1"/>
    <dbReference type="InParanoid" id="C7ZCB1"/>
    <dbReference type="OMA" id="PAQWWIM"/>
    <dbReference type="OrthoDB" id="5392779at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="106"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="637"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU38341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="721" mass="80572" checksum="13E2E9D6ED1854E9" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZD87</accession>
    <name>C7ZD87_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_105211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698919">
        <property type="protein sequence ID" value="EEU38178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043891.1">
        <property type="nucleotide sequence ID" value="XM_003043845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZD87"/>
    <dbReference type="STRING" id="660122.C7ZD87"/>
    <dbReference type="GeneID" id="9670253"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_105211"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_105211"/>
    <dbReference type="eggNOG" id="ENOG502SHX1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006237_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZD87"/>
    <dbReference type="OMA" id="TCTMNWA"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="797" mass="89187" checksum="7B80C25B573D0481" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEL2</accession>
    <name>C7ZEL2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine protease</fullName>
            <ecNumber evidence="6">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_87532</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S1B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="6"/>
    <dbReference type="EMBL" id="GG698921">
        <property type="protein sequence ID" value="EEU37716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043429.1">
        <property type="nucleotide sequence ID" value="XM_003043383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEL2"/>
    <dbReference type="GeneID" id="9669139"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87532"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87532"/>
    <dbReference type="eggNOG" id="ENOG502SXQ8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068119_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZEL2"/>
    <dbReference type="OMA" id="HLMTARH"/>
    <dbReference type="OrthoDB" id="10037376at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050966">
        <property type="entry name" value="Glutamyl_endopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008256">
        <property type="entry name" value="Peptidase_S1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15462">
        <property type="entry name" value="SERINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15462:SF8">
        <property type="entry name" value="SERINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00839">
        <property type="entry name" value="V8PROTEASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006991121" description="Serine protease" evidence="6">
        <location>
            <begin position="22"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="94"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU37716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="294" mass="30738" checksum="EBA2E248A7ACE757" modified="2009-10-13" version="1">MALITSFMAAAILAFGGTGLAIPTNSPGPSHSGGLYMTNHARSSEAPVPKVKTVSREDLKPFGGHNPKPSNITDPLKIRAIIGADDRVLWDSQEYPYSAIGRISGSDGGSCSAALVGPRHVATAKHCVPPEGVTTRFQPMYYDGERAGGSDAVEIIDMEQGDGPCFQMEDWAIFILADRLGDSFGYLGATTIDCDAQKNKPIFLHVGYPGDKGSSKPYRQEGISVVRCADCAPGGPLETDADGIPGQSGGPLWLEQGGSPYLYGVLSGVGEEGTGFASGQNLANAISKARADYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFB8</accession>
    <name>C7ZFB8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_78454</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698923">
        <property type="protein sequence ID" value="EEU37312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043025.1">
        <property type="nucleotide sequence ID" value="XM_003042979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFB8"/>
    <dbReference type="STRING" id="660122.C7ZFB8"/>
    <dbReference type="GeneID" id="9664977"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78454"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78454"/>
    <dbReference type="eggNOG" id="ENOG502SUMK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023947_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZFB8"/>
    <dbReference type="OMA" id="MNYAYYV"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="70"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="182"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU37312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="618" mass="68589" checksum="082D47F8CFCBAFCE" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFL7</accession>
    <name>C7ZFL7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRISE-like Rossmann-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_78366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698923">
        <property type="protein sequence ID" value="EEU37173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042886.1">
        <property type="nucleotide sequence ID" value="XM_003042840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFL7"/>
    <dbReference type="GeneID" id="9665025"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78366"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78366"/>
    <dbReference type="eggNOG" id="ENOG502RT3M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030125_2_0_1"/>
    <dbReference type="InParanoid" id="C7ZFL7"/>
    <dbReference type="OMA" id="TVVYPAY"/>
    <dbReference type="OrthoDB" id="1731983at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055222">
        <property type="entry name" value="PRISE-like_Rossmann-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487:SF4">
        <property type="entry name" value="SIRQ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22917">
        <property type="entry name" value="PRISE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRISE-like Rossmann-fold" evidence="1">
        <location>
            <begin position="8"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="399" mass="43958" checksum="2D54236112930300" modified="2009-10-13" version="1">MSDPQNHALVFGATGLVGWAVVDQLLSGYPTSTTFASVTGVSNRPVDASRTFWPEESDTRPELQLVSGVNLQSHDVLDQLREKVAGIEKTTHVFYFANVLVFAPYNDDFEKECQLNCDMMRNLASALNVLAPHLNSFVYSGGTRGYGIYIPDGIFTPPLEESMADNLPADYAKTVAYPWFREILTEASKGRGWTWTEVCPDAVVGFSPIGSNYSLALHWAQYLSLYAFNHGVRDAGDAKEVQVPFPGNNEAYHAHFTPVSSHILGRIAIHAALNSSSCGSKIINMLDRTKPTTFAELWPSIASFFGLIGVAPTADTTPQPPSEYIETHKHLFSENGQPNAISAGVGAGSKQLDSVGWWLTFDRQLSAERLRQVGFLEERQPVRGWTEAFERFRSAGIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFV5</accession>
    <name>C7ZFV5_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_86739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698924">
        <property type="protein sequence ID" value="EEU37042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042755.1">
        <property type="nucleotide sequence ID" value="XM_003042709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFV5"/>
    <dbReference type="GeneID" id="9664955"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86739"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86739"/>
    <dbReference type="eggNOG" id="ENOG502R6NI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1001469_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZFV5"/>
    <dbReference type="OMA" id="MDYNILM"/>
    <dbReference type="OrthoDB" id="4121058at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="278" mass="32600" checksum="9EE01CFCEBFB9012" modified="2009-10-13" version="1">MQSPVSIPVLSLNWFEQHVLDSILHPTTRLLITLIWKTEAFDHFNEGEFELLEHLHETQAGLLREWNRRNREAEECVEASKTNSRKRGPEDTPGPIAKRENNSLPVMRESREATIENIPPLRRYDAIYLIEGAKADQVDYYPDPPCHLLLSFSDGDTMRGAFHLGDFDALLFFAKRPRGPSNDRVPFIWRGRDRGWKKTYSGYTNKGWIQFLEDGTFRGRFDKFHLKFGGRREGDNWSRSYDNSAERFWLEWNNWHNPEDEIETADDSSDSEDCDMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZGL6</accession>
    <name>C7ZGL6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diacetyl reductase [(S)-acetoin forming]</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_69787</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698925">
        <property type="protein sequence ID" value="EEU36913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042626.1">
        <property type="nucleotide sequence ID" value="XM_003042580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZGL6"/>
    <dbReference type="FunCoup" id="C7ZGL6">
        <property type="interactions" value="160"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZGL6"/>
    <dbReference type="GeneID" id="9669942"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_69787"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_69787"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZGL6"/>
    <dbReference type="OMA" id="MFEVNVY"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF121">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU36913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="27944" checksum="4CA94131772C1B0A" modified="2009-10-13" version="1">MTSQQRTVIVTGSARGIGKAIALRLAEDGYDVCINDIQANKAGIDEVVSEIQKLGRRAYGHAADVSDLAQVEEMVAASVRELGPLNTMVANAGIAQVKPILDVTTDDLRRMFDINVFGTFNCYSVAAKQMIKQGSPGKLIGAASIAAMKSFPMLSHYSASKFAVRGFTQAFAMEMAPHKITVNAYAPGIVGTAMWDLIDEELAKVHGAKKGDMIKKHSDDLIALGRTSVPEDVSKMVSFLSGPDSDYVTGQTLVVDGGIIFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZH16</accession>
    <name>C7ZH16_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_86565</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698927">
        <property type="protein sequence ID" value="EEU36641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042354.1">
        <property type="nucleotide sequence ID" value="XM_003042308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZH16"/>
    <dbReference type="STRING" id="660122.C7ZH16"/>
    <dbReference type="GeneID" id="9669687"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86565"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86565"/>
    <dbReference type="eggNOG" id="KOG2820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_0_2_1"/>
    <dbReference type="InParanoid" id="C7ZH16"/>
    <dbReference type="OMA" id="WWGEKIF"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF37">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="8">
        <location>
            <begin position="8"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU36641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="438" mass="48593" checksum="287C4E81276A9FF7" modified="2009-10-13" version="1">MASNPSSYLIVGAGVFGVSTAFHLIKKYPDASVTIVDRDPYDGDNRVAASWDWNKVVRADYDDLVYCRLAIEAQDVFKSDPLWQPYFHETGVFWVCRSDYAQDVINNYKKLGRKADITAVSIEEAKKLYGGMFDQADYTGAKEVLINKTSGWAAAGDSLRAITREAMKLGVKYVVADVATLQIDGSGRCTGIKTAKGDVVSGSNVILCTGAYTSKLLEYSAASSGLEELRAGPRIVAGGITTGMATLDERSYETIYSKMPVGFQGYTAAEGPFIGSLPPTKDRELKWWGRTIFKNTRQVLPGRYISAPPDEKDYAQWKVSTKLKEDIDYSNQVFYGNKGAHWTMEKHRICWDAFTTSGDFIISPHSAAKGLYVATCGSFHGYKFFPVLGKYIVQMLEGELSPELAEKWAWDRERPDPALNPEWPRAEMKDLADPAARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHS0</accession>
    <name>C7ZHS0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_81280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698928">
        <property type="protein sequence ID" value="EEU36563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042276.1">
        <property type="nucleotide sequence ID" value="XM_003042230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHS0"/>
    <dbReference type="GeneID" id="9669381"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_81280"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_81280"/>
    <dbReference type="eggNOG" id="ENOG502RJB8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_829212_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZHS0"/>
    <dbReference type="OrthoDB" id="5064335at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU36563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="335" mass="38547" checksum="A93EEDA46FD7773B" modified="2009-10-13" version="1">MSQPNLSGQDLVSSPQTNRRGRRNTVDNPTLNDSELFAPSFPQDPQEGRISRLRRWTEEHRENNPVVPRNIEPLDQSMQDVALDDDEDEEPDDWDMVLDYLAVEESEDWYPRPTTMSRVRRYLWPRDEDEDQDQDHHHRPEPLVFDDEGLATIDEEDEDEDDRPDWRDPAWGYNIPFGPRVQYDYTFEQLYPRTARALDFAQSLPGMRRLAVARDVVAAWAPTVQNNIVRTYNGMAPRAVYTAQCTQEVLTMSAQVGSHFAVEVWTAGQNAAQMVQESWEAAQPTLRMLREGRAMRLLVEGDVMMMLLQDAAMAGLSAIPPYDLILRSGGGRRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHT3</accession>
    <name>C7ZHT3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_81292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698928">
        <property type="protein sequence ID" value="EEU36568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042281.1">
        <property type="nucleotide sequence ID" value="XM_003042235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHT3"/>
    <dbReference type="GeneID" id="9669237"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_81292"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_81292"/>
    <dbReference type="HOGENOM" id="CLU_966721_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZHT3"/>
    <dbReference type="OrthoDB" id="10499410at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU36568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="288" mass="31607" checksum="78D558506D71F69E" modified="2009-10-13" version="1">MSRKGVLYFRPYLALRLTTPTAHENISKLEDVGRDVALPGVPFLAQSLRPVPAACAQNCLPLPWPHSTLKNLTPWNDSAAENDLRWLGSKCEAGRFSEDSNKHAQTDNGTRQTASNPSVNFQAYTGHNSARLQLLRSQQIPNVLCGVPIDRAPPFGTGPPQAEALFSLKRAVANSAHLPPRTSSDKSPSHLPNILSFLFSPPSTAACNSLLFGYGLPAVPRQTSRRTSPRRPPFLRREIWVFNKGPAPVVLCPWEGRGRALPPSGGAASSPSFHWCWLWDNSNVFLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZI40</accession>
    <name>C7ZI40_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_52679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698929">
        <property type="protein sequence ID" value="EEU36333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042046.1">
        <property type="nucleotide sequence ID" value="XM_003042000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZI40"/>
    <dbReference type="STRING" id="660122.C7ZI40"/>
    <dbReference type="GeneID" id="9669042"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_52679"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_52679"/>
    <dbReference type="eggNOG" id="ENOG502QV31">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004184_10_1_1"/>
    <dbReference type="InParanoid" id="C7ZI40"/>
    <dbReference type="OMA" id="MATIYRM"/>
    <dbReference type="OrthoDB" id="3477286at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="84"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU36333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="691" mass="78265" checksum="DC7236EF54B5C1E3" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZI45</accession>
    <name>C7ZI45_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_97412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698929">
        <property type="protein sequence ID" value="EEU36379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042092.1">
        <property type="nucleotide sequence ID" value="XM_003042046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZI45"/>
    <dbReference type="GeneID" id="9674362"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_97412"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_97412"/>
    <dbReference type="eggNOG" id="ENOG502T0ZY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121037_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZI45"/>
    <dbReference type="OMA" id="PEYPKLM"/>
    <dbReference type="OrthoDB" id="3649348at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU36379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="153" mass="16047" checksum="55E3B1933129252C" modified="2009-10-13" version="1">MAETAPIPIILCGKTEGIGRAVIAALKPEIEVVHFVLAGESGQTIIPPLLAGESPPSHPESSTIGSGNYAQVPRAILLGGAFDEGTIATLRDAVKATSGARKIPWILQDLTLPAPPVGTPEYSALMTKRSKDALLKLDQDGKLDGSHDGIEWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZIJ1</accession>
    <name>C7ZIJ1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_6337</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698930">
        <property type="protein sequence ID" value="EEU36272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041985.1">
        <property type="nucleotide sequence ID" value="XM_003041939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZIJ1"/>
    <dbReference type="STRING" id="660122.C7ZIJ1"/>
    <dbReference type="GeneID" id="9674307"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_6337"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_6337"/>
    <dbReference type="eggNOG" id="KOG0737">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_21_3_1"/>
    <dbReference type="InParanoid" id="C7ZIJ1"/>
    <dbReference type="OMA" id="GIWINIE"/>
    <dbReference type="OrthoDB" id="39734at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF56">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="43"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU36272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="232" mass="25041" checksum="549F4F402C2961A9" modified="2009-10-13" version="1" fragment="single">DDIDVSFDDVHVDPVAVTSLRALTALATAAPLAFTYGLLAKEKILGVLLHGPPGTGKTMLAKAVAKEAHVSFLPVSGADFLSKWVGEDEKLVRAIFSIARKLDPCVIFIDEADSVFRQRTEDDSSWKRDLVSQFLLEWDGVKGGAKGGFVMAATNRMSDIDPAVLRRLPRRIFVGVPTAAQREGILKIHLRDESLGPDVTVEELAKLTVSYSGSDLKSLCVSAAMAAVYESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZIT8</accession>
    <name>C7ZIT8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_26554</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698931">
        <property type="protein sequence ID" value="EEU36085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041798.1">
        <property type="nucleotide sequence ID" value="XM_003041752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZIT8"/>
    <dbReference type="GeneID" id="9674122"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_26554"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_26554"/>
    <dbReference type="eggNOG" id="ENOG502QSKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZIT8"/>
    <dbReference type="OMA" id="WASNDNQ"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU36085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="38710" checksum="2870AF09D1AAB2F0" modified="2009-10-13" version="1" fragment="single">GAEAGAPAEAQTGDVNPMLAPSHWENTGPADNEADDADSSLGQDTGSSTASISSSIIQYRVINGRTYHADRGDTQYWASNDVQASEALDIIHHTSTLVIDGKLYLAPLDKGNVNKVLDVGTGTGIWAMDFGDEFPEAEVVGTDISPIQPTWVPPNVKFEIEDFTLDWTFPDDSFDFVHMRFLYGSVPDWYQLYERAYRVTKPGGWIETHEGDPMGQSDDGTLKPGSAIGEWGKFFYEGSKKLGRIFSPIPESLQEKGLKAAGFVDIETKTIKVPVGDWPKDEKQKEIGRFTNLGIETDVEGHITFMANLLDGWTREQVILYCAQLRRELRAKKTHAYYLQRIVWGRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJ00</accession>
    <name>C7ZJ00_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_49686</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698932">
        <property type="protein sequence ID" value="EEU35929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041642.1">
        <property type="nucleotide sequence ID" value="XM_003041596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJ00"/>
    <dbReference type="STRING" id="660122.C7ZJ00"/>
    <dbReference type="GeneID" id="9674098"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_49686"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_49686"/>
    <dbReference type="eggNOG" id="ENOG502SKUW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010408_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZJ00"/>
    <dbReference type="OMA" id="QWWPSVR"/>
    <dbReference type="OrthoDB" id="25921at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="80"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU35929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="794" mass="88633" checksum="3B17879ADAD30B0E" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJA5</accession>
    <name>C7ZJA5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_34927</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698933">
        <property type="protein sequence ID" value="EEU35870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041583.1">
        <property type="nucleotide sequence ID" value="XM_003041537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJA5"/>
    <dbReference type="GeneID" id="9673918"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_34927"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_34927"/>
    <dbReference type="eggNOG" id="ENOG502T9Y2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_3_1_1"/>
    <dbReference type="InParanoid" id="C7ZJA5"/>
    <dbReference type="OMA" id="SHMRKAT"/>
    <dbReference type="OrthoDB" id="9976870at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF15">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="36"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU35870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="358" mass="38933" checksum="C7B846DB719896DF" modified="2009-10-13" version="1">MAVSPDVTSINPQGLGLVLLVVTLFLTPPSTIVVALRCGIRLKHDVFSGNDVLMLVGWMLFMVVVGVISKGCYYGLGAKDERLNEYLHIWLFQTFYCSSLIFIKASICVTLLRIAVVKTHGIITWVTLTASCISTLIVIIGLFAMCRPVQANWDKSAGTCSPPIVITSLSYLVSAAAVATDWICAILPGFMLYKAQMKMATKVSISISLGLGVLASIATIVRLPYIKFYADPKDYPYNVGNIALWSVFESGTGIIAGSLPSLRRLLKNWVNFDSSHGHSSSNVTPFTGAGKSTVTSKVGVSTGRRHKSIIPNVKSDRDWEQLDDASSSRKIIVTVDMEMQSLERPMTSSRSRTPLSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJA8</accession>
    <name>C7ZJA8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_99468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698933">
        <property type="protein sequence ID" value="EEU35871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041584.1">
        <property type="nucleotide sequence ID" value="XM_003041538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJA8"/>
    <dbReference type="STRING" id="660122.C7ZJA8"/>
    <dbReference type="GeneID" id="9673920"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_99468"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_99468"/>
    <dbReference type="eggNOG" id="ENOG502SICY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002639_3_1_1"/>
    <dbReference type="InParanoid" id="C7ZJA8"/>
    <dbReference type="OMA" id="YADEKCK"/>
    <dbReference type="OrthoDB" id="3486565at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="211"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="692" mass="78661" checksum="415E42381E310B75" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJE3</accession>
    <name>C7ZJE3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_34902</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-lactamase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698933">
        <property type="protein sequence ID" value="EEU35835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041548.1">
        <property type="nucleotide sequence ID" value="XM_003041502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJE3"/>
    <dbReference type="GeneID" id="9673899"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_34902"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_34902"/>
    <dbReference type="eggNOG" id="ENOG502RX9C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019706_2_0_1"/>
    <dbReference type="InParanoid" id="C7ZJE3"/>
    <dbReference type="OMA" id="VGLPWEI"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058664">
        <property type="entry name" value="ARB_00930-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051478">
        <property type="entry name" value="Beta-lactamase-like_AB/R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935:SF95">
        <property type="entry name" value="BETA-LACTAMASE-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935">
        <property type="entry name" value="PENICILLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26335">
        <property type="entry name" value="ARB_00930_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="77"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-like ARB-00930-like C-terminal" evidence="3">
        <location>
            <begin position="405"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU35835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="563" mass="61229" checksum="DA4539360AFEB99F" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKD7</accession>
    <name>C7ZKD7_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_55522</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698938">
        <property type="protein sequence ID" value="EEU35506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041219.1">
        <property type="nucleotide sequence ID" value="XM_003041173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKD7"/>
    <dbReference type="GeneID" id="9675859"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55522"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55522"/>
    <dbReference type="eggNOG" id="ENOG502S2QN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_9_0_1"/>
    <dbReference type="InParanoid" id="C7ZKD7"/>
    <dbReference type="OMA" id="FHAGGFT"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF3">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="34"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="2">
        <location>
            <begin position="232"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU35506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="316" mass="34478" checksum="832047619095F77D" modified="2009-10-13" version="1">MFKRDYVYKEVDGVSVAATVIWKSTLDESPYGIAFHGGGFVIGSRHFIPEVEIDYLCGAHYVVVSADYRLCPQVPLHHVIQDAVDAFSWCKSDLPARLNNDAGIAVDGQKIVAFGQSAGGLLALHLGGLPKPPRAILDFYGVKYMSDQFWHSPLPVLAGIPPFEQTFLDKIYQEPILTTTVTSLETAAPSTSGTRKRGMPAPDLSIPRNAWLFTALKNGTQIKAIVTDGDFESVDPAQAFKPGFPPTFFLHGDADAMVPPRFSQKAFEDLRSHGVKTELSLVPNQSHGFDAGLSHVDAEWPAVRRALDFLVLNGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKJ9</accession>
    <name>C7ZKJ9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Alkaline proteinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_51284</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698940">
        <property type="protein sequence ID" value="EEU35453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041166.1">
        <property type="nucleotide sequence ID" value="XM_003041120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKJ9"/>
    <dbReference type="GeneID" id="9675815"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51284"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51284"/>
    <dbReference type="eggNOG" id="KOG1153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_1_4_1"/>
    <dbReference type="InParanoid" id="C7ZKJ9"/>
    <dbReference type="OMA" id="VEPDYIM"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988925" description="Alkaline proteinase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="10">
        <location>
            <begin position="37"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="165"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU35453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="415" mass="42994" checksum="DA9924C41DDC1CE5" modified="2009-10-13" version="1">MASIRRLALFLGALLPAALAAPVDGPVRRQETAIPNKYIITLKPEASDSKISAHLDWVGDVHRRSLSKRDTAGVEETYNISNWNAYAGEFDEATIEEIKSSPEVAFVEPDFEAYLWVEESSELSDRALTTQTGATWGLGTISHRTSGSTSYIYDTSAGSGSYAYVVDSGVQVGHSQFGTRASLGFNAFSGAHTDTLGHGTHVAGTIAGSTYGVAKQANIISVKVFQGNQGSTSTILSGFNWAVNDITSKGRQGRSVINLSLGGESSQTWISAINAAYNSGVLSVVAAGNGDINGNPLPVSSQSPANAPNALTVGAIDSSWRPASFTNYGAGVDIHAPGVSVLSSYIGSNTATRSLSGTSMACPHVAGLALYLQVLEGLSTPAAVTNRIKALGTSGRITGTLNGSPNLVAYNGNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKS1</accession>
    <name>C7ZKS1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_16436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698941">
        <property type="protein sequence ID" value="EEU35344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041057.1">
        <property type="nucleotide sequence ID" value="XM_003041011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKS1"/>
    <dbReference type="STRING" id="660122.C7ZKS1"/>
    <dbReference type="GeneID" id="9675550"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_16436"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_16436"/>
    <dbReference type="eggNOG" id="KOG2495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019845_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZKS1"/>
    <dbReference type="OMA" id="GHEHLAF"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF5">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="2"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="342" mass="37378" checksum="E883420BF9083B57" modified="2009-10-13" version="1" fragment="single">QNVVVIGGSFAGIELAKRLAETLPTGYKAVLIEKNSHLNYSFNFPRFSVMEGHEHEAFIPYDAICRGGPPGILTRIQDKVVEITEEQIILASGNKIDYTYLAIATGSSQPLPVQVSATELQDACREMQSVQEKIKASQRIAIVGGGAVGVQIASDTKSFYPHKDVTLIHSRGQLMKYFGKRLQDYTLTALRDELKIRVLLNERPKLPPQGNMATSATLTFSDGREEKFDLIIGCTGQRPNSSILQSLYPSAISKETSRILVEPTLQVSGDGSLATGSRIFAFGDVADHGGPHMARAGWMQSRVVLDNILAMIRGEEPSQTYKPQMFIEGAIKLTLGKAKNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKZ2</accession>
    <name>C7ZKZ2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_36964</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698942">
        <property type="protein sequence ID" value="EEU35282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040995.1">
        <property type="nucleotide sequence ID" value="XM_003040949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKZ2"/>
    <dbReference type="GeneID" id="9675511"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_36964"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_36964"/>
    <dbReference type="eggNOG" id="ENOG502RYZ8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009377_1_1_1"/>
    <dbReference type="InParanoid" id="C7ZKZ2"/>
    <dbReference type="OMA" id="CKPSLCW"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="267"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU35282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="635" mass="70333" checksum="E141AA1BEB6F4BDF" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLU5</accession>
    <name>C7ZLU5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_37449</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698947">
        <property type="protein sequence ID" value="EEU35024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040737.1">
        <property type="nucleotide sequence ID" value="XM_003040691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLU5"/>
    <dbReference type="GeneID" id="9679153"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_37449"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_37449"/>
    <dbReference type="HOGENOM" id="CLU_2360219_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZLU5"/>
    <dbReference type="OrthoDB" id="5238092at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU35024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="11485" checksum="3E416C7DAF7CF217" modified="2009-10-13" version="1">MQIGITPEFRQQVIEGYSKDSKLGRIRDYIKEIQNADRQNRRPKTIPFRPWELSDELLYHVGYEGKRRLCIPRPLVKSILEIVHDNKHHFGINRMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZN41</accession>
    <name>C7ZN41_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_88857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698962">
        <property type="protein sequence ID" value="EEU34568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040281.1">
        <property type="nucleotide sequence ID" value="XM_003040235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZN41"/>
    <dbReference type="GeneID" id="9678090"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88857"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88857"/>
    <dbReference type="HOGENOM" id="CLU_750264_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZN41"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="369" mass="39348" checksum="F8BE944F19BA7A52" modified="2009-10-13" version="1">MYLTGHGTGVYNLMLPKVQACVRRRINEMVRGGIIQQALNQGVTEYTWREDADNFLHRPGWISNWNVVFGQHLGRARQHTENPRAVALRGVEARRVAAAALFPRAVHVEANTVIHGNVTNGRGTVRGANVSNIVNSAAGPDACRGAEGVVQAPLVLEDDYDADQYHDDSEDDCDDIEMTDAPAPAPETPQTNNTTNQGGNDNASNDAIRGGIAIANANSKTGPAAANANNNYNINHHHWCPHGWQQMAPIAQGAATNGMPPPPPPHVPQFPPEQPLVQPVTPGINTPVSVSNIPSMLSSSPTTIISLETASSITPSESASSVSHTRRIGRGSPEAEITTLMLEELRACSTDQLCDAIDTLSGKIIGNIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNR1</accession>
    <name>C7ZNR1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_96603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039746.1">
        <property type="nucleotide sequence ID" value="XM_003039700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNR1"/>
    <dbReference type="STRING" id="660122.C7ZNR1"/>
    <dbReference type="GeneID" id="9677870"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_96603"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_96603"/>
    <dbReference type="eggNOG" id="ENOG502RZMK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_12_0_1"/>
    <dbReference type="InParanoid" id="C7ZNR1"/>
    <dbReference type="OMA" id="ANFDWVH"/>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="155"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="377" mass="41802" checksum="7369DDBA0F904818" modified="2009-10-13" version="1">MSSQTILLIGATGYVGGTVLDHFIKAHDDEILKNLTFDLPVRSEEAADKLRSAYGDRVNPIQWAGLHDVEFITELASNYDIIISTGSGFIPQGAEAFVKGLARRVKPGASPPWMFHISGCSNLSDRPLTQEAFPDREWNDTDGNAVYEFLKAEDAREPYPQRTTEVLVLTAAQETGVQAVSLNTPIIFGTGTGLFNQQGIIIPIIMRYVIQHGHGFKLNETSVWDWVHVEDLADVFVLLTRTVLEREDRGVGYIPSGTSGMIFPATGRALQLEIMQNCLDVAFAEGILPREGTPSEKEIRQVSLQELADEITAGLTDMAERGWAGTKLMKGTEAKRLLGWNPTRLEEAWKQDFKDELEALKNGQRPWTLESCIGQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNU9</accession>
    <name>C7ZNU9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_85549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039778.1">
        <property type="nucleotide sequence ID" value="XM_003039732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNU9"/>
    <dbReference type="GeneID" id="9677696"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85549"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85549"/>
    <dbReference type="HOGENOM" id="CLU_983621_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZNU9"/>
    <dbReference type="OMA" id="RISCKMC"/>
    <dbReference type="OrthoDB" id="3525430at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="298" mass="32827" checksum="44D1936DA2399DFD" modified="2009-10-13" version="1">MSQYSTQYQSYIPWDYTLISTSGSCPSKSRVLATYAVTAAIISTLCLLVGHRDIARWLTFGKLDSEKAWAWRLTWVFPFGFSLAAAAINVVIIAQHEGRSSDYPRHSLFLLQLTLPRMSFFCLLIAFWVQLLAKSPQANAADKGLVAELQHGSAAASALIAELLIQIPLLYYLGKIGYFAFNQKYLPTDSNYGQVPKAAKMMHGAALYHLGSSCAALLLLIVFCTGLFPSSELTKHLRMKYVICVCVVLGMFTFCADWIFWAGFLELAGDTYCVPELELQAGIRIVLSALGAFFGGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNV6</accession>
    <name>C7ZNV6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial phosphate carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_72198</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039976.1">
        <property type="nucleotide sequence ID" value="XM_003039930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNV6"/>
    <dbReference type="STRING" id="660122.C7ZNV6"/>
    <dbReference type="GeneID" id="9677911"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_72198"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_72198"/>
    <dbReference type="eggNOG" id="KOG0767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039456_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZNV6"/>
    <dbReference type="OMA" id="IYAQCKT"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF15">
        <property type="entry name" value="MIR1-PHOSPHATE TRANSPORTER OF THE MITOCHONDRIAL CARRIER (MCF) FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="14"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="113"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU34263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="33263" checksum="BEBACF1F485E613F" modified="2009-10-13" version="1">MASKQSEVPNFTPSDYVKFFGAGALAATSTHGAATPIDVVKTRIQVDDALKGYNMLKAGRTIVAKEGASALLTGFGPTAVGYLVQGGAKFAGYEFFKKKYITLIGGPEKAVDHRTGIYLAASASAEFFADILLCPLEATRIRLVSQKGYANGLVSGFGRMARQEGFKGFYSGFVPLLFKQVPFAVGQFSVHEAVNEIIYRAMGPERKEKLTRLESTAVELTSGVTAGAAAAVLSHPADTLLSAINKGAGDPKQGATSRMFQLAKEFGPKRLLLSGLGPRVVMTCGLVGGQFVIYAQCKALTGAPPSIEIHKEASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZP98</accession>
    <name>C7ZP98_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14 15">Diphosphomevalonate decarboxylase</fullName>
            <ecNumber evidence="3 14 15">4.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">NECHADRAFT_96684</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(R)-5-diphosphomevalonate + ATP = isopentenyl diphosphate + ADP + phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:23732"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.33"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:23733"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 15">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14 15">Belongs to the diphosphomevalonate decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.33" evidence="3 14 15"/>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039821.1">
        <property type="nucleotide sequence ID" value="XM_003039775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZP98"/>
    <dbReference type="FunCoup" id="C7ZP98">
        <property type="interactions" value="687"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZP98"/>
    <dbReference type="GeneID" id="9677663"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_96684"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_96684"/>
    <dbReference type="eggNOG" id="KOG2833">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040369_4_2_1"/>
    <dbReference type="InParanoid" id="C7ZP98"/>
    <dbReference type="OMA" id="LTLHAMM"/>
    <dbReference type="OrthoDB" id="10253702at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004163">
        <property type="term" value="F:diphosphomevalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000018">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000005">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005935">
        <property type="entry name" value="Mev_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029765">
        <property type="entry name" value="Mev_diP_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053859">
        <property type="entry name" value="MVD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041431">
        <property type="entry name" value="Mvd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01240">
        <property type="entry name" value="mevDPdecarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977:SF3">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18376">
        <property type="entry name" value="MDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22700">
        <property type="entry name" value="MVD-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015950">
        <property type="entry name" value="Mev_P_decrbx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8 15" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Diphosphomevalonate decarboxylase-like N-terminal" evidence="17">
        <location>
            <begin position="13"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Mvd1 C-terminal" evidence="16">
        <location>
            <begin position="198"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR015950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEU34108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="391" mass="41432" checksum="B38C3D05FB447DAD" modified="2009-10-13" version="1">MADNKVYRASTTAPVNIAVVKYWGKRDPKLNLPTNSSLSVTLSQADLRTLTTASCSNSYTSGDSLTLNGESADVSGARTQACFRELRARRAALEAADSSLPKLSAMNLKLVSENNFPTAAGLASSAAGFAALVQAIALLYELPDSPSDLSLVARQGSGSACRSLFGGYVAWRMGEKDDGSDSKAELVAPASHWPEMRALILVASAAKKGVSSTSGMQQTVATSGLFKERITNIVPANMALMEEAVKNKDFAKFAEVTMRESNSFHATCADTYPPIFYMNDVSRAAIRAVEDINTKAGKTVAAYTFDAGPNCVVYYLEENANAVLGTFYQALSGVDGFKENAASAKSAFELDSGLADTLREGVSRVISTAVGEGPIKTEEYLVGEDGEAVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPB6</accession>
    <name>C7ZPB6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase (KR) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_50515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040036.1">
        <property type="nucleotide sequence ID" value="XM_003039990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZPB6"/>
    <dbReference type="STRING" id="660122.C7ZPB6"/>
    <dbReference type="GeneID" id="9677675"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_50515"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_50515"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_4_1"/>
    <dbReference type="InParanoid" id="C7ZPB6"/>
    <dbReference type="OMA" id="SEHLWNE"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF35">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="38550" checksum="C5E95E4C1A108929" modified="2009-10-13" version="1">MSANLKHRAAWEAGFPGLFWKQVFHRVPKIPSHIDLHGETAIVTGSSQGLGLECARQLLQLGLNELILAVRSQSRGDEAAKQLQAKFPDATIRVWILDMESYDSVKQFASRCETLKRLDIVILNAGCGKASYQRCTGDKGREVTLQVNFLATMLLTILLVPILREKNSVVSGGKKFASTPGRLTIVGSDMALWVKMEEPSGSFLDVLDAEEGFDGFDQYGKTKLLLPMFISKLAEIVSADDVIINVVNPSSTRGTALMRESKGQYAAQAFVFITGVIFGRNIVDGTRQYLHSALVLGKESHGSFGDWEIRPYPPLMYTGPGQRMTEKLWKETLEELEIGDIERALAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQP7</accession>
    <name>C7ZQP7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NIPSNAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_89272</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699004">
        <property type="protein sequence ID" value="EEU33671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039384.1">
        <property type="nucleotide sequence ID" value="XM_003039338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQP7"/>
    <dbReference type="GeneID" id="9666901"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89272"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89272"/>
    <dbReference type="eggNOG" id="ENOG502T12M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176883_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZQP7"/>
    <dbReference type="OMA" id="ITTHGVW"/>
    <dbReference type="OrthoDB" id="4992579at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012577">
        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07978">
        <property type="entry name" value="NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002989489" description="NIPSNAP domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="NIPSNAP" evidence="2">
        <location>
            <begin position="23"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU33671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="123" mass="13645" checksum="DECF81363B46AF0B" modified="2009-10-13" version="1">MKISFAFLFALPATLARQQPPTELRSYTLATVNATNQYVQIWKKHIESLKQFNITTRAVWTPEGNDKQVMALVQYAIGDDPADVGAAYMASEAFTNDMVGFNFSNFESVVSTVLDPTSFSPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZR96</accession>
    <name>C7ZR96_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_98456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699050">
        <property type="protein sequence ID" value="EEU33460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039173.1">
        <property type="nucleotide sequence ID" value="XM_003039127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZR96"/>
    <dbReference type="STRING" id="660122.C7ZR96"/>
    <dbReference type="GeneID" id="9666697"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_98456"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98456"/>
    <dbReference type="eggNOG" id="ENOG502SKNT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025077_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZR96"/>
    <dbReference type="OMA" id="VPEFYHA"/>
    <dbReference type="OrthoDB" id="2684236at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU33460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="400" mass="44859" checksum="50E8AF4F7A7108AD" modified="2009-10-13" version="1">MIYDTVTKTVVFANALIPSEPNVGNLETALAYPDVSHAAVYLALLEYFRNLWLSASALDIEWTNINDVLNHAAVYAHHASDRVAVQLAKDYLPPLDVLLVWYAFMLDTDAYRAAYHAACRDREPHVPPRIQKLCFPWPAIRDVIDIEKIQFSLPRAAQTLFLTLSGQSADILTYLKSPPAYIKSGTLPFEVNLTAEVKKHKKFINEAHGLLWIRAPALNRSLARASSSALRSLTLGPGATDPGLRIRDDIPIFIHIPPPYTSSSSADPPAAMQGQLSSLSPGQLRQIQDDLGFYNAVKSARRRSEPLPTRPPIAAEKDAERIAKEKQKEARYLPGLNEYIKVLLDGKQKIRRQKHTTPFNKGTRPILFVGKLGPTAYFVPIRWHQYELDFSLSSLEFRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHJ3</accession>
    <name>C7YHJ3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_73390</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Required for assembly of cytochrome c oxidase (complex IV).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the COA3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053633.1">
        <property type="nucleotide sequence ID" value="XM_003053587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YHJ3"/>
    <dbReference type="FunCoup" id="C7YHJ3">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YHJ3"/>
    <dbReference type="GeneID" id="9664595"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_73390"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_73390"/>
    <dbReference type="eggNOG" id="ENOG502SEY5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153999_2_1_1"/>
    <dbReference type="InParanoid" id="C7YHJ3"/>
    <dbReference type="OMA" id="WYTLNAV"/>
    <dbReference type="OrthoDB" id="10018333at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041752">
        <property type="entry name" value="Coa3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018628">
        <property type="entry name" value="Coa3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09813">
        <property type="entry name" value="Coa3_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c oxidase assembly factor 3 mitochondrial coiled-coil" evidence="10">
        <location>
            <begin position="20"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU47920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="74" mass="8315" checksum="3BE2B7EBB5CF0F09" modified="2009-10-13" version="1">MPPSPQSTYYDRRLRQGPALVRARRPYLFKNAVTGLGLLTVVGAIYYYTLNAVGQDNFEDVKVPDEPRKPASSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHU3</accession>
    <name>C7YHU3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_65738</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S9 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054412.1">
        <property type="nucleotide sequence ID" value="XM_003054366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YHU3"/>
    <dbReference type="FunCoup" id="C7YHU3">
        <property type="interactions" value="1190"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YHU3"/>
    <dbReference type="GeneID" id="9674633"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_65738"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_65738"/>
    <dbReference type="eggNOG" id="KOG1463">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029573_2_1_1"/>
    <dbReference type="InParanoid" id="C7YHU3"/>
    <dbReference type="OMA" id="ESKIYHA"/>
    <dbReference type="OrthoDB" id="1418352at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000010">
        <property type="entry name" value="26S proteasome regulatory subunit RPN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040780">
        <property type="entry name" value="Rpn6_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040773">
        <property type="entry name" value="Rpn6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18503">
        <property type="entry name" value="RPN6_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18055">
        <property type="entry name" value="RPN6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="223"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU48699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="423" mass="47631" checksum="AE1B84354CC3CFD7" modified="2009-10-13" version="1">MAAAESARVQEAQKLAKSDPRKAEAIYKEIISQAPSTTSDAATREYETALISLGELYRDEKKTQELVDLVKESRSVFSSFAKAKSAKLVRQLLDLFKEIPNSTDIEIAVTKDCIEWATAERRAFQRQDLEARLVALQMAKQSYYEALGLINGLLRELKRLDDKLRLVEVQLLESRVYHALGNIPKARAALTSARTSAASVYTPPLLQANLDMQSGMLHAEDKDFNTAFSYFIEALDGYHTQDEGPKAQAALQYMLLCKIMLNLVDDVNNLMTSKQALKYAGKNLEAMKAIARAHSNRSLEEYERALSSYRYELGSDAFIRNHLRRLYDAMLEQNLIKVIEPFSRVEIDHIAKMVGLDTQQVERKLSQMILDKVIIGVLDQGAGCLIIFDETQRDESYDAALATIEKLSNVVDVLYTNQASMLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIQ4</accession>
    <name>C7YIQ4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">HDA2104</name>
        <name evidence="15" type="ORF">NECHADRAFT_31703</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054558.1">
        <property type="nucleotide sequence ID" value="XM_003054512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIQ4"/>
    <dbReference type="FunCoup" id="C7YIQ4">
        <property type="interactions" value="1041"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YIQ4"/>
    <dbReference type="GeneID" id="9676479"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_31703"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_31703"/>
    <dbReference type="eggNOG" id="KOG1342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007727_0_0_1"/>
    <dbReference type="InParanoid" id="C7YIQ4"/>
    <dbReference type="OMA" id="EHRWDKH"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10004">
        <property type="entry name" value="RPD3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="14">
        <location>
            <begin position="39"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="383"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="404"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="508"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="566"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="578"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="629"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU48845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="650" mass="72578" checksum="BB7AEDBC1D13BFAF" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIS1</accession>
    <name>C7YIS1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Copper acquisition factor BIM1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_102399</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054568.1">
        <property type="nucleotide sequence ID" value="XM_003054522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIS1"/>
    <dbReference type="GeneID" id="9664689"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102399"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102399"/>
    <dbReference type="eggNOG" id="ENOG502S92W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070647_2_1_1"/>
    <dbReference type="InParanoid" id="C7YIS1"/>
    <dbReference type="OMA" id="YPCAGVP"/>
    <dbReference type="OrthoDB" id="5333578at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21176">
        <property type="entry name" value="LPMO_auxiliary-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046936">
        <property type="entry name" value="BIM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046530">
        <property type="entry name" value="BIM1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992:SF2">
        <property type="entry name" value="COPPER ACQUISITION FACTOR BIM1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20238">
        <property type="entry name" value="BIM1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002987282" description="Copper acquisition factor BIM1-like domain-containing protein" evidence="10">
        <location>
            <begin position="19"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Copper acquisition factor BIM1-like" evidence="11">
        <location>
            <begin position="17"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU48855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="224" mass="24079" checksum="0AC5E43404A0B054" modified="2009-10-13" version="1">MMAFKSLLALASVQAVSAHFGLVFPEWRADTLSEENEERYSQWTYPCAGVDYNERNVTDWPLEGGALKLELHHPWSYVFVNLGLGENSTNFNVSLTPQFLNVTSPGQLCIEELKLPSDVKVSDGDFASIQVVTVGDSGSALYNCADIRFKKDAKGPSNCTSESEYFAVKEQTGEEEEQSSQGNSSNTDSKESGNDNAAGILGANMVALTSVAGLAAAFVMGIGL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJ02</accession>
    <name>RCF1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName>Respiratory supercomplex factor 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RCF1</name>
        <name type="synonym">AIM31</name>
        <name type="ORF">NECHADRAFT_102404</name>
    </gene>
    <organism>
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with the respiratory chain complex III/complex IV supercomplex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RCF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053897.1">
        <property type="nucleotide sequence ID" value="XM_003053851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJ02"/>
    <dbReference type="FunCoup" id="C7YJ02">
        <property type="interactions" value="74"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YJ02"/>
    <dbReference type="EnsemblFungi" id="NechaT102404">
        <property type="protein sequence ID" value="NechaP102404"/>
        <property type="gene ID" value="NechaG102404"/>
    </dbReference>
    <dbReference type="GeneID" id="9676530"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102404"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102404"/>
    <dbReference type="eggNOG" id="KOG4431">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087356_0_0_1"/>
    <dbReference type="InParanoid" id="C7YJ02"/>
    <dbReference type="OMA" id="QRWIREL"/>
    <dbReference type="OrthoDB" id="6604018at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050355">
        <property type="entry name" value="RCF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297:SF3">
        <property type="entry name" value="HIG1 DOMAIN FAMILY MEMBER 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297">
        <property type="entry name" value="HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000399640" description="Respiratory supercomplex factor 1, mitochondrial">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="3">
        <location>
            <begin position="12"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="153"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="93"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="230" mass="25679" checksum="7AD6A3602F3B1B7F" modified="2009-10-13" version="1">MADGPPSIPGPLPSSFDSDQDFYNERPMQKVFRKIKEEPLIPLGIGLTSLAFVNAYRALRRGDSKQANRMFRARVAAQGFTVIAMLAGSMYYQKDREKSKELRQLQEQRDAEEKRLKWIRELEARDDEEKAMKARLEQRRQLVQAQRAEEAEAAAAAAATTEEKPEATSGGAGGILSRIGLWPQGEKKEEEKKVAEELVEETAGDKSGKKKNPKSSLGDLGEIISSQKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJJ3</accession>
    <name>C7YJJ3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_75698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054699.1">
        <property type="nucleotide sequence ID" value="XM_003054653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJJ3"/>
    <dbReference type="GeneID" id="9676620"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75698"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75698"/>
    <dbReference type="eggNOG" id="ENOG502SJ1Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1111402_0_0_1"/>
    <dbReference type="InParanoid" id="C7YJJ3"/>
    <dbReference type="OMA" id="ITWIGFE"/>
    <dbReference type="OrthoDB" id="2922289at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40788:SF1">
        <property type="entry name" value="IPA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU48986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="237" mass="26807" checksum="C3EC61B5DB77A4C1" modified="2009-10-13" version="1">MRSQELEAELAPIKMEIDLSEYAVPIDNLLEPWMADKALDMMEAHVVQRAGATLGYLYHILVEECIAELEDQCEQAKARAKNDSKGEQIPVLATQEPQEERVESQRRKEKTRPAQPSALNVAINPPAEQAQEPAQIPETLSVSDSTMNILMKIFKKSEARGAVSWVSFEAAMADLDFSAHSKYSSVYSFWPPEFIAICRSVTIHRPHNGQVEGVRLSILSLRLKRTYEWSEQTFKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJM5</accession>
    <name>C7YJM5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NhNSP3</name>
        <name evidence="6" type="ORF">NECHADRAFT_31971</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054014.1">
        <property type="nucleotide sequence ID" value="XM_003053968.1"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YJM5"/>
    <dbReference type="GeneID" id="9663871"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_31971"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_31971"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_228664_0_0_1"/>
    <dbReference type="InParanoid" id="C7YJM5"/>
    <dbReference type="OMA" id="HRVRYLD"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45398">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45398:SF1">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="19"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1769"/>
            <end position="1845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2435"/>
            <end position="2468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2485"/>
            <end position="2512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2445"/>
            <end position="2464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU48301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="2623" mass="291360" checksum="6A28638BFF825AF8" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7YK75</accession>
    <name>C7YK75_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_74509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054112.1">
        <property type="nucleotide sequence ID" value="XM_003054066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YK75"/>
    <dbReference type="GeneID" id="9676738"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74509"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74509"/>
    <dbReference type="eggNOG" id="ENOG502RA8Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1556279_0_0_1"/>
    <dbReference type="InParanoid" id="C7YK75"/>
    <dbReference type="OMA" id="MYRGLEN"/>
    <dbReference type="OrthoDB" id="4897217at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU48399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="165" mass="17745" checksum="37D6CCAAAE8D3705" modified="2009-10-13" version="1">MAGSPEANAPPVIRNNPLMPPAKQERIHIWRTEVASALSLPTAPSLSSSLSSSSAATPDPDPDTSFGMSPPSPATSRSRSLWKRISWRFGPKRRAAANAAAAAAELPEGRTAMYRGLETRGPRGHDDMEEGGILERDSEGANGLREKQERLMRAARLLGHGPERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7YKF6</accession>
    <name>C7YKF6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome production factor 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ribosome biogenesis protein RPF2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_89977</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
            <location evidence="1 4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RPF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054161.1">
        <property type="nucleotide sequence ID" value="XM_003054115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YKF6"/>
    <dbReference type="FunCoup" id="C7YKF6">
        <property type="interactions" value="971"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YKF6"/>
    <dbReference type="GeneID" id="9676770"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89977"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89977"/>
    <dbReference type="eggNOG" id="KOG3031">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049783_0_0_1"/>
    <dbReference type="InParanoid" id="C7YKF6"/>
    <dbReference type="OMA" id="VGLKPMF"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039770">
        <property type="entry name" value="Rpf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728">
        <property type="entry name" value="BRIX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728:SF0">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="28"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU48448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="310" mass="35706" checksum="07A5FC9CE8F8926B" modified="2009-10-13" version="1">MLRQVKPRNARSKRALEKRESKVNENPKTCLFLRGTTCSQIVQDALNDLHQMRQPLAKKFTKKNPIHPFDDATSLEFFSEKNDASLLLFGSSQKKRPHTLTFVRTFGYKTLDMLELYLDPESFRTISQFKTKKFAIGLRPMLLFAGTAFESPVSNEFTLAKSMFIDFFKGEPSDKIDVEGLQYIVSISAEESTGEGDAKPAIHLRVYTISTKRSGQRLPRVEVEEIGPRMDFRVGRIREADESMLKEAMKKPRGLEERTKKNITTDAMGDKIGRVHLGKQDLSELQLRKMKGLKRSRKEKEEEERDRIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLE5</accession>
    <name>C7YLE5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_67078</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052484.1">
        <property type="nucleotide sequence ID" value="XM_003052438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YLE5"/>
    <dbReference type="GeneID" id="9663652"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_67078"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_67078"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_309064_0_0_1"/>
    <dbReference type="InParanoid" id="C7YLE5"/>
    <dbReference type="OrthoDB" id="2740448at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF6">
        <property type="entry name" value="VIC POTASSIUM ION CHANNEL, BETA SUBUNIT (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU46771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="954" mass="106257" checksum="AA199D32EEEF0820" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLK0</accession>
    <name>C7YLK0_FUSV7</name>
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        <recommendedName>
            <fullName evidence="5">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_91722</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052993.1">
        <property type="nucleotide sequence ID" value="XM_003052947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YLK0"/>
    <dbReference type="STRING" id="660122.C7YLK0"/>
    <dbReference type="GeneID" id="9671039"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_91722"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_91722"/>
    <dbReference type="eggNOG" id="KOG3026">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069491_1_0_1"/>
    <dbReference type="InParanoid" id="C7YLK0"/>
    <dbReference type="OMA" id="CMAVWSQ"/>
    <dbReference type="OrthoDB" id="79171at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd20446">
        <property type="entry name" value="Tudor_SpSPF30-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297:SF2">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297">
        <property type="entry name" value="ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="5">
        <location>
            <begin position="99"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="55"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="150"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU47280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="278" mass="31287" checksum="A931E8E0FF3B935D" modified="2009-10-13" version="1">MSPLSDLEDEKKLYQEQLDIVHSQLRDDPENVELKALKEELNNFIDLLNENIAELKPKQAPKPAPKQPSPPAEPEKWSRENHPAFKKATPAEEKEDTPVHYQVNDTVLAKWVTGDKAFYPARITSITGSSTDPIYIVKFKTYDNTETLRSRDIRPVSNKRKADGTPLSSAPATPPAPGLVTSAGATVYPEAKREAENNGDVKPPKAKKLKAKKELEKNKNKWQEFSAKSKFGKTHKKESMFRTPEGVHGRVGFTGSGQTMRKDPTRSRHVYQMNDELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7YMX1</accession>
    <name>C7YMX1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_78027</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053235.1">
        <property type="nucleotide sequence ID" value="XM_003053189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YMX1"/>
    <dbReference type="GeneID" id="9671268"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78027"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78027"/>
    <dbReference type="eggNOG" id="ENOG502SKUK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009377_1_0_1"/>
    <dbReference type="InParanoid" id="C7YMX1"/>
    <dbReference type="OMA" id="ASHMIQA"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="354"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU47522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="753" mass="83911" checksum="71739B7069147BE2" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7YN24</accession>
    <name>C7YN24_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_99737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052764.1">
        <property type="nucleotide sequence ID" value="XM_003052718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YN24"/>
    <dbReference type="GeneID" id="9664251"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_99737"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_99737"/>
    <dbReference type="eggNOG" id="ENOG502SNSN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_402887_0_0_1"/>
    <dbReference type="InParanoid" id="C7YN24"/>
    <dbReference type="OMA" id="NIHRYTA"/>
    <dbReference type="OrthoDB" id="3549294at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU47051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="727" mass="80860" checksum="F34E8D1A2A35503D" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7YN60</accession>
    <name>C7YN60_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_35215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052780.1">
        <property type="nucleotide sequence ID" value="XM_003052734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YN60"/>
    <dbReference type="STRING" id="660122.C7YN60"/>
    <dbReference type="GeneID" id="9664346"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_35215"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_35215"/>
    <dbReference type="eggNOG" id="ENOG502S0Y1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040048_1_0_1"/>
    <dbReference type="InParanoid" id="C7YN60"/>
    <dbReference type="OMA" id="FMASCEL"/>
    <dbReference type="OrthoDB" id="165382at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="48"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU47067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="333" mass="37335" checksum="0413BEA04AC5A326" modified="2009-10-13" version="1">MPSDKVLDICAYHRRDFDLVLVRSRLHETQSVSKSLQTTFETSPTSGLGVLDSLPVELLWIILRNLDLLSFFRFRHINRRARALATAVLEYRAVVRHGLEGLRGVLRGGLGQAFTIRDLYIPLVSEKCTLCGEFGGFLFLVTATRCCFACIKSSPDLRVISPSTLSRLAKISPKRLHQALGSGLRTVSGIYSMEEKLVRRPTFLVASQPAIARLQLLGLLNQNTIGALSKWNEHENQRFMASTAFPWYDPYSGKVESGVCCKGCQVKEENLLVGSDERDHVFSRSGYLSHFESCTEAQKLWDQSEGGARPVQEPEFTRRCGHFSLLDLDGLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNJ8</accession>
    <name>C7YNJ8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_79332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052293.1">
        <property type="nucleotide sequence ID" value="XM_003052247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNJ8"/>
    <dbReference type="STRING" id="660122.C7YNJ8"/>
    <dbReference type="GeneID" id="9672854"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79332"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79332"/>
    <dbReference type="eggNOG" id="KOG4044">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066901_0_0_1"/>
    <dbReference type="InParanoid" id="C7YNJ8"/>
    <dbReference type="OMA" id="HVCVFQT"/>
    <dbReference type="OrthoDB" id="269496at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050993">
        <property type="entry name" value="Isochorismatase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119:SF3">
        <property type="entry name" value="ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="2">
        <location>
            <begin position="18"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU46580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="187" mass="19782" checksum="BDA152807FD93E51" modified="2009-10-13" version="1">MSSAPAQLRFKCDKENPKILVLTTQKVLNFAKALSIPVVTTTQTSAKLGPTVPSLADLLPSPPHDKTRFSMFIPSVVADLAPGSEIALVGIESHICITQTALDLRDAGHKVYVLADGVSSCNPGEVGVALDRLRAEPGITVTSSESWMYECVGDASHPAFKSLIGVVKGSMADTKQVWQSLPPGSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7YP42</accession>
    <name>C7YP42_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_78631</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051494.1">
        <property type="nucleotide sequence ID" value="XM_003051448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YP42"/>
    <dbReference type="GeneID" id="9673097"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78631"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78631"/>
    <dbReference type="eggNOG" id="ENOG502SHVI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007426_5_1_1"/>
    <dbReference type="InParanoid" id="C7YP42"/>
    <dbReference type="OMA" id="NIRWRVA"/>
    <dbReference type="OrthoDB" id="4934715at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF74">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="108"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU45781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="460" mass="51133" checksum="A610B8A6364C0BD0" modified="2009-10-13" version="1">MGLPTTRMSLLTSVACLPKEDILAMMPPRKVVDRHVSHFFNAFDFAPDIGASGLSATESQDTLDTYRTLTIHCLVAGDYLRSGRYTIETLTLHFALDQNVNVDTHAGTWVLMGVVIRVAMRMGLHRDPAHWPTIRPLQAELRRRIWMTLYDMDFFTSTQVGLPRIIKDSQCDTQPPAHLVDGDISLEHDETPVERPLTEPSSLLYIIQRHRIITLAAEIYDATEGGPPLAATISALSTKLEETVQSIPAWLKHKPLEASIADNPVTILYRMFLDILIHKAVYLLHRRAFVKGSSGEENAKSSKACIDAALAILDHQRRMSEETQPGGLMYAIRWKVATSLNHEFLQATMMLCFALSRSDEDAEPSSTNFMPRRDDIMEALATARGLWEMNAGQSTEAQRAVKTISVVLKHGESPTTASLDDLFKQMPGVIAPSYLDPFEDMALDPSLFGAFGSMPGDLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPW0</accession>
    <name>C7YPW0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MED9</name>
        <name evidence="9" type="ORF">NECHADRAFT_78890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 9 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051632.1">
        <property type="nucleotide sequence ID" value="XM_003051586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YPW0"/>
    <dbReference type="STRING" id="660122.C7YPW0"/>
    <dbReference type="GeneID" id="9673302"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78890"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78890"/>
    <dbReference type="eggNOG" id="ENOG502SW8C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097220_2_0_1"/>
    <dbReference type="InParanoid" id="C7YPW0"/>
    <dbReference type="OMA" id="IRIQKAH"/>
    <dbReference type="OrthoDB" id="5414694at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011425">
        <property type="entry name" value="Med9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07544">
        <property type="entry name" value="Med9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU45919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="141" mass="15057" checksum="3272F45B4C30AB3D" modified="2009-10-13" version="1">MSSSSGPHPLALPPTFSPDTLDALSELSLVLARVRAGIQSSAGITTEPAPGTTGHNAPGGPTLSFKDVPGATDGLKHKLQRARAQVRELPDMNRPIAEQAEEIRELEARIEMQRAVLQKLRDEAAGKERKDDVAAADKMQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPX8</accession>
    <name>C7YPX8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Eukaryotic translation initiation factor 3 subunit E</fullName>
            <shortName evidence="4">eIF3e</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">INT6</name>
        <name evidence="7" type="ORF">NECHADRAFT_68275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the eIF-3 subunit E family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051640.1">
        <property type="nucleotide sequence ID" value="XM_003051594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YPX8"/>
    <dbReference type="STRING" id="660122.C7YPX8"/>
    <dbReference type="GeneID" id="9673387"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_68275"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_68275"/>
    <dbReference type="eggNOG" id="KOG2758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031132_0_0_1"/>
    <dbReference type="InParanoid" id="C7YPX8"/>
    <dbReference type="OMA" id="NCPWILR"/>
    <dbReference type="OrthoDB" id="417252at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21378">
        <property type="entry name" value="eIF3E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03004">
        <property type="entry name" value="eIF3e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016650">
        <property type="entry name" value="eIF3e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019010">
        <property type="entry name" value="eIF3e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10317">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09440">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21357">
        <property type="entry name" value="EIF3E_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016255">
        <property type="entry name" value="eIF3e_su6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01186">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="245"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU45927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="439" mass="49944" checksum="171E1D971873A940" modified="2009-10-13" version="1">MEELLNAVSADGSSIMPLIARHLSRHLLFPLIQFESERADEQGDDAKAKEILSSKIKLLEDTNMTDYVATMYCELHGVSEAPAEYNKKRQEVLSELEKYEQATAKIADLLTQDEVVNGLRSDKVANLEFLKNQHGVTMEMVNALYDFGQFQFRCGQYGPAADMLYQFRVLSTDNDKVSAATWGKLASEILQTNWESAVDELKNVRENIDSKLFNNPRAQLDHRTMLVHWSLFPLFNSESAREPILDMFFSAPYINTIQTSCPWILRYLIAAVITGRGRARNSSIQQKQVKDIIRYVRQEAYEYTDPITQFVNALYIAHDFEAAREALSMAEQVCRSDFFLASSADAFVDAARHLICESYCKIFSRMNIRDLSSKLGLNPDDGEKWIVNLIRETRLDAKIDSQDGTVVMNHPPNNVYQQVIEKTKGGFFRTQVLNAAVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQ36</accession>
    <name>C7YQ36_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxyanthranilate 3,4-dioxygenase</fullName>
            <ecNumber evidence="9">1.13.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">3-hydroxyanthranilate oxygenase</fullName>
            <shortName evidence="9">3-HAO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">3-hydroxyanthranilic acid dioxygenase</fullName>
            <shortName evidence="9">HAD</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Biosynthesis of nicotinic acid protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BNA1</name>
        <name evidence="10" type="ORF">NECHADRAFT_100032</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:17953"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:77612"/>
            <dbReference type="EC" id="1.13.11.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 3-HAO family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.6" evidence="9"/>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052114.1">
        <property type="nucleotide sequence ID" value="XM_003052068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQ36"/>
    <dbReference type="FunCoup" id="C7YQ36">
        <property type="interactions" value="189"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YQ36"/>
    <dbReference type="GeneID" id="9668897"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100032"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100032"/>
    <dbReference type="eggNOG" id="KOG3995">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095765_0_0_1"/>
    <dbReference type="InParanoid" id="C7YQ36"/>
    <dbReference type="OMA" id="KPPVGNQ"/>
    <dbReference type="OrthoDB" id="204928at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000334">
        <property type="term" value="F:3-hydroxyanthranilate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06123">
        <property type="entry name" value="cupin_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000093">
        <property type="entry name" value="3-hydroxyanthranilate 3,4-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00825">
        <property type="entry name" value="3_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010329">
        <property type="entry name" value="3hydroanth_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03037">
        <property type="entry name" value="anthran_nbaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497:SF1">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06052">
        <property type="entry name" value="3-HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU46401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="180" mass="20442" checksum="C9FB79F9869FC13F" modified="2009-10-13" version="1">MLSAPINLPKWLEENSHLLQPPINNYCVYNEEFSVMIVGGPNARTDYHINLTPEWFYQYKGAMMLKVVDEGKFRDIIIREGDMFLLPGNTPHNPVRFANTVGVVLEQRRPKDSLDRMRWYCAECGEVVHEAAFHCTDLGTQIKAAVQDFKGDNDKRTCGKCGTLADWAPKPGSIKDPNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQF3</accession>
    <name>C7YQF3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PRA1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_68407</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PRA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052172.1">
        <property type="nucleotide sequence ID" value="XM_003052126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQF3"/>
    <dbReference type="FunCoup" id="C7YQF3">
        <property type="interactions" value="282"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YQF3"/>
    <dbReference type="GeneID" id="9673550"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_68407"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_68407"/>
    <dbReference type="eggNOG" id="KOG3142">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103851_1_1_1"/>
    <dbReference type="InParanoid" id="C7YQF3"/>
    <dbReference type="OMA" id="PWTVFFN"/>
    <dbReference type="OrthoDB" id="63113at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317:SF0">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU46459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="176" mass="19482" checksum="672BADF4484C829D" modified="2009-10-13" version="1">MARIQIPLDVITSRINFGERFQGLRSGPLSGRFSNLRPLSEFLDVKRVSKPANFAEMQSRVNYNLSHFSSNYAVIFVMLSIYALLTNWVLLFDIIFVVASMWIIGRLDGNDLEIGTFRASTSQLYTGLVVIAVPLGLWASPFSTMLWLVGASGVTIIGHAAFMDKPIDEAFSGEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7YR41</accession>
    <name>C7YR41_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_41418</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051103.1">
        <property type="nucleotide sequence ID" value="XM_003051057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YR41"/>
    <dbReference type="SMR" id="C7YR41"/>
    <dbReference type="STRING" id="660122.C7YR41"/>
    <dbReference type="GeneID" id="9665744"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_41418"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_41418"/>
    <dbReference type="eggNOG" id="KOG4205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_0_0_1"/>
    <dbReference type="InParanoid" id="C7YR41"/>
    <dbReference type="OMA" id="AMPNMMN"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12577">
        <property type="entry name" value="RRM1_Hrp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12330">
        <property type="entry name" value="RRM2_Hrp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000466">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein HRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000025">
        <property type="entry name" value="RNA-binding protein Musashi homolog 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034156">
        <property type="entry name" value="Hrp1_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF6">
        <property type="entry name" value="RNA-BINDING (RRM_RBD_RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="115"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="208"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="279"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="395"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="467"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="491"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU45390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="546" mass="58527" checksum="3292D8DCB63DFFA4" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRL2</accession>
    <name>C7YRL2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AA1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_106136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051193.1">
        <property type="nucleotide sequence ID" value="XM_003051147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YRL2"/>
    <dbReference type="GeneID" id="9665900"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_106136"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_106136"/>
    <dbReference type="eggNOG" id="ENOG502RK0U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139292_0_0_1"/>
    <dbReference type="InParanoid" id="C7YRL2"/>
    <dbReference type="OMA" id="DGHCCFT"/>
    <dbReference type="OrthoDB" id="4912193at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002987503" description="AA1-like domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU45480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="18727" checksum="2DAB281946702082" modified="2009-10-13" version="1">MRSSALLTLFCSLALAAVIPRNTVWDNHCCFTLHDVSTGATVQENDANGYLFFNAGQTDGFFCIDLTNPLDQLRDHLYNACFINPPDGSVKCIDPTPGFQSWTLKKVGSDTLLLHDGDSTFNHCPKPSTSTKGTVLYSNNHPNVASCKKTTLKAKNFQGTCKNFSARSEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRP2</accession>
    <name>C7YRP2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Coatomer subunit epsilon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_61192</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the COPE family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050820.1">
        <property type="nucleotide sequence ID" value="XM_003050774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YRP2"/>
    <dbReference type="FunCoup" id="C7YRP2">
        <property type="interactions" value="205"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YRP2"/>
    <dbReference type="GeneID" id="9667981"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_61192"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_61192"/>
    <dbReference type="eggNOG" id="KOG3081">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049363_1_0_1"/>
    <dbReference type="InParanoid" id="C7YRP2"/>
    <dbReference type="OMA" id="SWVGMRE"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000613">
        <property type="entry name" value="Coatomer subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006822">
        <property type="entry name" value="Coatomer_esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805:SF0">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04733">
        <property type="entry name" value="Coatomer_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016478">
        <property type="entry name" value="Coatomer_esu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU45107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="294" mass="31446" checksum="9231C8B1D6A125BD" modified="2009-10-13" version="1">MDPYSAEGELINIHNHFHQGQYQEVIDFDTSSFSPDNALPVRVLVLRARLALGQAEDVLADVKGESDPALEALGALAELSLGKVDSAVKTVEKLAASSADNTTVLIVGGTVLQAAGKSDEALALLTQHQGSLDAVALIVQIHLQQNRTDLALKEVSAARRWAQDSLLVNLAESWVGLRVGGEKYQQAFYVFEELAQAPSTSSVRSLVSQAVCELHLGRTEEAQAALDQALEKDANSADAIANLLVLNVISGNDSKEFTEKLKAADANHQFLADLEEKSALFDKAATKYSPKVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7YS16</accession>
    <name>C7YS16_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glycosylphosphatidylinositol anchor biosynthesis protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_80581</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050879.1">
        <property type="nucleotide sequence ID" value="XM_003050833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YS16"/>
    <dbReference type="STRING" id="660122.C7YS16"/>
    <dbReference type="GeneID" id="9668122"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_80581"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_80581"/>
    <dbReference type="eggNOG" id="KOG3144">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069429_1_0_1"/>
    <dbReference type="InParanoid" id="C7YS16"/>
    <dbReference type="OMA" id="WQRWPVT"/>
    <dbReference type="OrthoDB" id="17366at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009580">
        <property type="entry name" value="GPI_biosynthesis_protein_Pig-F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06699">
        <property type="entry name" value="PIG-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU45166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="26451" checksum="6EAAF9909403FBF6" modified="2009-10-13" version="1">MSTTLIKGAPAQPAAPKAVVPAIPLLNTSLALPVSIVHQLVLAGLFVWRFEALVADPVSTLQIGLPVVAVIQTLYVTLCLPAAGSSGAKGSKKLRPGEKKKSDTREPKAFATAVISLVLSLILTPVLHILFVLFGAPFLTHASHTFLCAAHIAVLAIYPIFYVRGSDPVPLQAVVSVSAPFDQTFGGFVGTVVGAWLGAVPIPLDWDREWQKWPVTIVAGAYIGYFVGSKLLGSAFYGKRWAVSEIKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSB4</accession>
    <name>C7YSB4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_100656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050933.1">
        <property type="nucleotide sequence ID" value="XM_003050887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSB4"/>
    <dbReference type="STRING" id="660122.C7YSB4"/>
    <dbReference type="GeneID" id="9668166"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100656"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100656"/>
    <dbReference type="eggNOG" id="ENOG502S0A4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089054_0_0_1"/>
    <dbReference type="InParanoid" id="C7YSB4"/>
    <dbReference type="OMA" id="CSQFFVG"/>
    <dbReference type="OrthoDB" id="6021263at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024388">
        <property type="entry name" value="Ribosomal_mL58"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12824">
        <property type="entry name" value="MRP-L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU45220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="207" mass="23244" checksum="3470E0179BF6D477" modified="2009-10-13" version="1">MEFRSLARPAARLLKSPASGLPLIPSRGHKTTARTKRSLKIAPHESFQPDRKTAFPAADSIIYNPPASEASPLHTPFLFLPPNDARRAAITRLRHTPGSPVAPPAEGKLPPKMNYPRRDPNYNLKATDIQEMKRLRAEDPVTWSVNKLAEKFGCSTIFVKMAAPAPAGHLKALQAKQERREARWGAIRTKAREDRKRRTEMLYRGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSY8</accession>
    <name>C7YSY8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyrate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_93927</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 13">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="3"/>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051445.1">
        <property type="nucleotide sequence ID" value="XM_003051399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSY8"/>
    <dbReference type="STRING" id="660122.C7YSY8"/>
    <dbReference type="GeneID" id="9666350"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_93927"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_93927"/>
    <dbReference type="eggNOG" id="KOG0409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035117_6_1_1"/>
    <dbReference type="InParanoid" id="C7YSY8"/>
    <dbReference type="OMA" id="NTATCQA"/>
    <dbReference type="OrthoDB" id="21615at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000056">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF7">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="9">
        <location>
            <begin position="20"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="10">
        <location>
            <begin position="210"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU45732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="342" mass="35500" checksum="B79688A1818C0B0E" modified="2009-10-13" version="1">MAASSSDTVAFIGQRPPSTLGLGVMGYPMALNLQAGLGQDKTLLICDTNLEALDRFQAEARGTATVKIVSNGFEAAKAANTVFTMLPGSGAVKSVYLDPQTGILAGAVAAAEESGRTPERKIVVECGTIETDCIHSVADSCREVSSSKLSDTLVFVDAPVSGGPMGANAATLTFMVGCPPSLSQEVFPIVKSYLGHMGNREGIFLCGDVGAGTAFKIINNYLSAITSLAASEALNIGVKAGLDPKTLTDVINASGGQCWVTSKSNPVPGVQANVPSSRGYEGGFRIELCAKVLGMGTKLAESVGARTILDKPTQQAFSEAMGDERYSGKDARVVYQWLNKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7YU38</accession>
    <name>C7YU38_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Topoisomerase 1-associated factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_96220</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the timeless family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050447.1">
        <property type="nucleotide sequence ID" value="XM_003050401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YU38"/>
    <dbReference type="FunCoup" id="C7YU38">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YU38"/>
    <dbReference type="GeneID" id="9674845"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_96220"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_96220"/>
    <dbReference type="eggNOG" id="KOG1974">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004390_0_0_1"/>
    <dbReference type="InParanoid" id="C7YU38"/>
    <dbReference type="OMA" id="VNHHRHT"/>
    <dbReference type="OrthoDB" id="310853at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044998">
        <property type="entry name" value="Timeless"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006906">
        <property type="entry name" value="Timeless_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940:SF4">
        <property type="entry name" value="PROTEIN TIMELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940">
        <property type="entry name" value="TIMEOUT/TIMELESS-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04821">
        <property type="entry name" value="TIMELESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0236">DNA replication inhibitor</keyword>
    <keyword evidence="6" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Timeless N-terminal" evidence="9">
        <location>
            <begin position="36"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="554"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="797"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="897"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1008"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="556"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="576"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="943"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="953"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="971"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1038"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1062"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1085"/>
            <end position="1103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU44734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1133" mass="129710" checksum="9D0B4B1CBC52785F" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7YUA4</accession>
    <name>C7YUA4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Knr4/Smi1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_49379</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KNR4/SMI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050091.1">
        <property type="nucleotide sequence ID" value="XM_003050045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YUA4"/>
    <dbReference type="FunCoup" id="C7YUA4">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YUA4"/>
    <dbReference type="GeneID" id="9674876"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_49379"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_49379"/>
    <dbReference type="eggNOG" id="ENOG502QTAZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024700_0_0_1"/>
    <dbReference type="InParanoid" id="C7YUA4"/>
    <dbReference type="OMA" id="ESLMVHD"/>
    <dbReference type="OrthoDB" id="2305498at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097708">
        <property type="term" value="C:intracellular vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070880">
        <property type="term" value="P:fungal-type cell wall beta-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009203">
        <property type="entry name" value="Knr4/Smi1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051873">
        <property type="entry name" value="KNR4/SMI1_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432:SF1">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017023">
        <property type="entry name" value="KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Knr4/Smi1-like" evidence="3">
        <location>
            <begin position="135"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="359"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="360"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU44378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="503" mass="54929" checksum="8915956CD60C982F" modified="2009-10-13" version="1">MTSYDRHSTFDSPYRTGRHVPLQNGGNGIMTGVATASDSRADITSPYSDDTGRASPLPPGARSPSNTPYSPGLRSLGARNASQGDGFEVQSPGDVQMQNFSDGLPPAPPVAHSWRRIDAWADENYPELYDQLCEGATNNDLNDLEHQLDCSLPQDVRESLMIHDGQERGGNPTGIIFSHMLLDCEEIVQEWDNWRTVNHQYLLETSVAKPATPSKAFGGSNEASSSRQGAAAGNNPGVWRQDLISRQDSVPPNSVQKAYAHAGWIPLVRDWGGNNLAVDVAPGPGGQWGQIILFGRDYDTKYVVARSWAAFLAVVADDLNSGKWYVDEDTNELKLREFKEARVEPSYFSILRWRMDQKYGRRAPSKRRSMGPKPNSPLGSRSSSPYASGGENGEGRGRSMQRLSGSSPLASPMRPGYGKATPLSRVTEESAIPAELASAHIQPEKLVEVETPRPSDEGKAPKVSTNLPRVESDLLKIEEETTSPKVNGKKPEVAEDSMKTIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7YV29</accession>
    <name>C7YV29_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Membrane insertase YidC/Oxa/ALB C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_48589</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050625.1">
        <property type="nucleotide sequence ID" value="XM_003050579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YV29"/>
    <dbReference type="FunCoup" id="C7YV29">
        <property type="interactions" value="635"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YV29"/>
    <dbReference type="GeneID" id="9675008"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_48589"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_48589"/>
    <dbReference type="eggNOG" id="KOG1239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029282_5_1_1"/>
    <dbReference type="InParanoid" id="C7YV29"/>
    <dbReference type="OMA" id="GWKNAQT"/>
    <dbReference type="OrthoDB" id="2148490at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20069">
        <property type="entry name" value="5TM_Oxa1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="YidC/Oxa/ALB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF66">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEIN OXA1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane insertase YidC/Oxa/ALB C-terminal" evidence="12">
        <location>
            <begin position="190"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="437"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="448"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU44912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="481" mass="53120" checksum="FE6B5DDB01BD7867" modified="2009-10-13" version="1">MLPSRGIVRSLPSGAFQRRLPSQSRTLSRKFGDARQFGTALRNPRASLTPSRIGVKNVAAPVVLGGISTTRAFSLWPFGKKKTEEPAATAEPITSEPVTPSETIEATSATVNDAAGIPAEAVADVTTAEPTAVTTDFDLEAIANLASPNILNMEEKLGFLHEIGLDYGWGPTSMMQWALEHVHVYSGLGWGGSIIATALILRVIMFYPQVRSLRFNAAMQQMKKDPRGQEAMDLVKKGYQSGDREMLQKGQFLNKMVREQYGAKNSGMLWSFVQIPFSFGLFRIISGMVHIPVPSMENAGFLWFTDLTASDPYFLLPALGTSLLFGAMAVNAKYTPASQKAMMKKMMWVFGTVGFIGTTFLSAGVNLMMVSTGSATLLTALILNNETVRVAFGLPILEVEKPKYEPPRVTQSSGVSGLRERLTDNLNDMKKGLSDQVNNYTGQYAGTEQERAEKKRREQMQKLEDMRRKLERDEFEKKYKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C7YV35</accession>
    <name>C7YV35_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_85137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050629.1">
        <property type="nucleotide sequence ID" value="XM_003050583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YV35"/>
    <dbReference type="GeneID" id="9674584"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85137"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85137"/>
    <dbReference type="eggNOG" id="ENOG502RMM6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1917600_0_0_1"/>
    <dbReference type="InParanoid" id="C7YV35"/>
    <dbReference type="OrthoDB" id="5086035at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU44916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="132" mass="14741" checksum="C2F89BC7AB40B683" modified="2009-10-13" version="1">MSRIQYRSSLSRALETLSGLATRIHCVEDKDFDAELVAFLVPHLNDDNARRRLLSFLDHNNGMWACLASICAEGYGVRKGTVGGCECPYHGNPRVIFIIGHGRQQLPLMKTWVGVMAPAWGKRQSWGRGSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVC2</accession>
    <name>C7YVC2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_101748</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050669.1">
        <property type="nucleotide sequence ID" value="XM_003050623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVC2"/>
    <dbReference type="FunCoup" id="C7YVC2">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="GeneID" id="9675057"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101748"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101748"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="InParanoid" id="C7YVC2"/>
    <dbReference type="OMA" id="MFQAKFD"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015793">
        <property type="term" value="P:glycerol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF69">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="18"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="512"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="517"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="530"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU44956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="540" mass="59313" checksum="F00C9E1D348C2944" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7YW51</accession>
    <name>C7YW51_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_29778</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049824.1">
        <property type="nucleotide sequence ID" value="XM_003049778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YW51"/>
    <dbReference type="STRING" id="660122.C7YW51"/>
    <dbReference type="GeneID" id="9677195"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_29778"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_29778"/>
    <dbReference type="eggNOG" id="ENOG502S675">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051064_0_1_1"/>
    <dbReference type="InParanoid" id="C7YW51"/>
    <dbReference type="OMA" id="HTWNLYS"/>
    <dbReference type="OrthoDB" id="89349at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF9">
        <property type="entry name" value="XYLOGLUCAN-SPECIFIC ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012338874" evidence="3">
        <location>
            <begin position="16"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU44111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="244" mass="26033" checksum="2273F709C6FB28C5" modified="2009-10-13" version="1">MKSAIVAALAGLAAASPTRLIPRGQFCGQWDSETAGAYTIYNNLWGKDNAESGEQCTTNSGEQSDGSIAWSVEWSWTGGQGQVKSYPNAVVEIEKKTLGEVSSIPSAWDWTYTGDGIIANVAYDLFTSSTESGDAEYEFMIWLSALGGAGPISNDGSPVATVELAGTSWKLYQGKNNQMTVFSFVAESDVNNFCGDLADFTDYLVDNHGVSSSQILQSVGAGTEPFEGTNAVFTTNNYHADVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWH4</accession>
    <name>C7YWH4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_74303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049895.1">
        <property type="nucleotide sequence ID" value="XM_003049849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWH4"/>
    <dbReference type="GeneID" id="9677493"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74303"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74303"/>
    <dbReference type="eggNOG" id="ENOG502T1TD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015630_1_1_1"/>
    <dbReference type="InParanoid" id="C7YWH4"/>
    <dbReference type="OMA" id="HHRGAKN"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053083">
        <property type="entry name" value="TF_kinase-domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44305">
        <property type="entry name" value="SI:DKEY-192D15.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44305:SF24">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE C03B1.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="120"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU44182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="593" mass="66351" checksum="1EF29996B755D041" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>C7YX23</accession>
    <name>C7YX23_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_95059</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049469.1">
        <property type="nucleotide sequence ID" value="XM_003049423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YX23"/>
    <dbReference type="GeneID" id="9666130"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95059"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95059"/>
    <dbReference type="eggNOG" id="ENOG502SK98">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015161_0_1_1"/>
    <dbReference type="InParanoid" id="C7YX23"/>
    <dbReference type="OMA" id="WNHAALM"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU43756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="585" mass="66598" checksum="AC87BACC8BBA34E0" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXM7</accession>
    <name>C7YXM7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_94941</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049328.1">
        <property type="nucleotide sequence ID" value="XM_003049282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXM7"/>
    <dbReference type="GeneID" id="9666384"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94941"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94941"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="C7YXM7"/>
    <dbReference type="OMA" id="CYFAVHV"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000364">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF79">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="63"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU43615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="522" mass="57892" checksum="FF4D5DA15FD00C7E" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXW3</accession>
    <name>C7YXW3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_45101</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049375.1">
        <property type="nucleotide sequence ID" value="XM_003049329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXW3"/>
    <dbReference type="FunCoup" id="C7YXW3">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="GeneID" id="9677013"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45101"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45101"/>
    <dbReference type="eggNOG" id="ENOG502QQ7I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019691_0_0_1"/>
    <dbReference type="InParanoid" id="C7YXW3"/>
    <dbReference type="OMA" id="IAFCFYR"/>
    <dbReference type="OrthoDB" id="4064873at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052478">
        <property type="entry name" value="Metabolite_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779:SF4">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="71"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU43662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="565" mass="62588" checksum="3FFDDAD9D241B506" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYE8</accession>
    <name>C7YYE8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog</fullName>
            <ecNumber evidence="12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NECHADRAFT_95438</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the RPAP2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU42994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048707.1">
        <property type="nucleotide sequence ID" value="XM_003048661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYE8"/>
    <dbReference type="STRING" id="660122.C7YYE8"/>
    <dbReference type="GeneID" id="9665810"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95438"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95438"/>
    <dbReference type="eggNOG" id="ENOG502SCU8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049331_1_0_1"/>
    <dbReference type="InParanoid" id="C7YYE8"/>
    <dbReference type="OMA" id="IQAQKDT"/>
    <dbReference type="OrthoDB" id="2590500at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043175">
        <property type="term" value="F:RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039693">
        <property type="entry name" value="Rtr1/RPAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007308">
        <property type="entry name" value="Rtr1/RPAP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038534">
        <property type="entry name" value="Rtr1/RPAP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732:SF0">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04181">
        <property type="entry name" value="RPAP2_Rtr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51479">
        <property type="entry name" value="ZF_RTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RTR1-type" evidence="14">
        <location>
            <begin position="81"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU42994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="268" mass="30294" checksum="169CFD931977B05E" modified="2009-10-13" version="1">MASTAKQPAKGILKKPKDAAKEPDVDPREVALQHARIIQHRKDLEAEILDSLILLSEYPLVREAPHNAANPAPSDIADFKAHVRLFQPSDYDDLIIERNVNELCGYSLCAKPRRQVGPGGDWKILANGDIVKRKDVEMWCSQKCARRALYVKVQLNETAAWERAGIPDIQIELLDETQTDVDRAAQKLGDLKLEEQRQAARDTAALALERGQREPMQRDKVKVTLKEKDVEAPSPVPDIPQVYDDDHLVVEGYKSKLRLDNEKEDQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYY4</accession>
    <name>C7YYY4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Stress activated MAP kinase interacting protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_95591</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048792.1">
        <property type="nucleotide sequence ID" value="XM_003048746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYY4"/>
    <dbReference type="STRING" id="660122.C7YYY4"/>
    <dbReference type="GeneID" id="9665986"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95591"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95591"/>
    <dbReference type="eggNOG" id="KOG3739">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005130_0_0_1"/>
    <dbReference type="InParanoid" id="C7YYY4"/>
    <dbReference type="OMA" id="PFQKFAH"/>
    <dbReference type="OrthoDB" id="241990at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000263">
        <property type="entry name" value="Stress activated MAP kinase interacting protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031567">
        <property type="entry name" value="CRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008828">
        <property type="entry name" value="Sin1/Avo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031313">
        <property type="entry name" value="Sin1_PH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335:SF1">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16978">
        <property type="entry name" value="CRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16979">
        <property type="entry name" value="SIN1_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIM" evidence="3">
        <location>
            <begin position="333"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="SIN1-type PH" evidence="4">
        <location>
            <begin position="719"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="493"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="668"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="670"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU43079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="827" mass="90826" checksum="6FE2AE6BA3868FF0" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZ48</accession>
    <name>C7YZ48_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Class E vacuolar protein-sorting machinery protein HSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Class E vacuolar protein-sorting machinery protein hse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">NECHADRAFT_83908</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STAM family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048827.1">
        <property type="nucleotide sequence ID" value="XM_003048781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZ48"/>
    <dbReference type="STRING" id="660122.C7YZ48"/>
    <dbReference type="GeneID" id="9666090"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83908"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83908"/>
    <dbReference type="eggNOG" id="KOG2070">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002632_0_0_1"/>
    <dbReference type="InParanoid" id="C7YZ48"/>
    <dbReference type="OMA" id="DWPGPDS"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11883">
        <property type="entry name" value="SH3_Sdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056685">
        <property type="entry name" value="DUF7783"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056686">
        <property type="entry name" value="DUF7784"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057827">
        <property type="entry name" value="WW_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25006">
        <property type="entry name" value="DUF7783"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25008">
        <property type="entry name" value="DUF7784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23518">
        <property type="entry name" value="WW_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="8 10" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="66"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="15">
        <location>
            <begin position="777"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="14">
        <location>
            <begin position="946"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="212"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="692"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="697"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEU43114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1200" mass="134221" checksum="5D5DDAF65C5B509B" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZ63</accession>
    <name>C7YZ63_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NECHADRAFT_95648</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048836.1">
        <property type="nucleotide sequence ID" value="XM_003048790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZ63"/>
    <dbReference type="GeneID" id="9665684"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95648"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95648"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010365_3_1_1"/>
    <dbReference type="InParanoid" id="C7YZ63"/>
    <dbReference type="OMA" id="GKNGWVF"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000023">
        <property type="entry name" value="Putative ferric-chelate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF24">
        <property type="entry name" value="REDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="297"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU43123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="585" mass="65612" checksum="EF280AE6B7A74F85" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1U9</accession>
    <name>C7Z1U9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_105529</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU42063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047776.1">
        <property type="nucleotide sequence ID" value="XM_003047730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1U9"/>
    <dbReference type="STRING" id="660122.C7Z1U9"/>
    <dbReference type="GeneID" id="9671736"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_105529"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_105529"/>
    <dbReference type="eggNOG" id="ENOG502SI68">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_3_5_1"/>
    <dbReference type="InParanoid" id="C7Z1U9"/>
    <dbReference type="OMA" id="CENSIDD"/>
    <dbReference type="OrthoDB" id="5022096at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF167">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="115"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="250"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU42063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="386" mass="42423" checksum="8CBEFE05A470F15D" modified="2009-10-13" version="1">MDLPPVPSNPKENGVKDILAATVFIISLSTITVLARLYVRLLVIRNTGWDDWFMVLSLALAWAGQGVIFGQLSHGAGRHKGDVDPDVYMVGMKLNFISQPIFLIAICVVKLATLMFQCTDIRILWDPSVKATCWSQQTLQGLSYTNSALNIITDLLFAIVIPTPMLWKLNVHFRTRVTLIGILGLGVFACAAAFVKLGYITNYGKLGDWLWDSRNITIWTSLELNVGIIAGSLPCLRPIFRRFLGSTYGKSSRKTPTTGATNYGRGTLRSGNNWHTLSSGRRGDDETSSQKAINTGVMEYELRDRIATPAGITNKTTVLTDIDARSSDESVDRGGHGQRYPPGITKTTTMTVEILIPFNYLFFVSCNFLALVTVVVGRVGLSTAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z219</accession>
    <name>C7Z219_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_85994</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU41922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047635.1">
        <property type="nucleotide sequence ID" value="XM_003047589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z219"/>
    <dbReference type="STRING" id="660122.C7Z219"/>
    <dbReference type="GeneID" id="9671597"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85994"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85994"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_12_1"/>
    <dbReference type="InParanoid" id="C7Z219"/>
    <dbReference type="OMA" id="HAWNGQE"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF28">
        <property type="entry name" value="PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="58"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU41922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="188" mass="20651" checksum="062F5BA813DD0AE2" modified="2009-10-13" version="1">MSTVVSTTDVEPNGATPTSEQPSLGPHADAQGSSNQPQPDLSGPQQPETSPPSSREVKYLIVEDNKVNRKIMGKLFGKLGLEGQFHMTENGQEGVDAYKRNPQQCRFIFMDISMPIKGGMEASKEIRDYEHGQGLSPAVIVGMHPRMAAGGQADRQVERFKNEFGMDDVIDKPVRTDALKSIIEKWPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z2M7</accession>
    <name>C7Z2M7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_54095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047217.1">
        <property type="nucleotide sequence ID" value="XM_003047171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z2M7"/>
    <dbReference type="GeneID" id="9676058"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_54095"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_54095"/>
    <dbReference type="eggNOG" id="ENOG502RVYI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_2_2_1"/>
    <dbReference type="InParanoid" id="C7Z2M7"/>
    <dbReference type="OMA" id="PNDEKHI"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU41504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="31064" checksum="CD474E34E9B4ADA9" modified="2009-10-13" version="1">MSNEEQTRRGIAIDPEVTGSDDNDISDDVERAPNDEKHVEAFDVSNDMADKFPSAEVIGVDISPTQPSWTPLNVKFQIDDAQLDWTFEPASFDFIHVRYMHGAFDDWPKLYRQMFKFLKPGGWFQHIEPNIHLKCENPKSVAENETFKQWAELFFDAGDKIGRTFRVTDGIMEESAREAGFKDIVHKIITIPLSGWPKEEKLKKEGQFVGLYMDLSLDGFALYPIGQILGWSREKVDDIVSKMRAIIRNPRHLGSGDMHIVYGRKPLKTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z2W0</accession>
    <name>C7Z2W0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_87735</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047441.1">
        <property type="nucleotide sequence ID" value="XM_003047395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z2W0"/>
    <dbReference type="GeneID" id="9676104"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87735"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87735"/>
    <dbReference type="eggNOG" id="ENOG502SN5A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1300023_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z2W0"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF17">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09900)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU41728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="212" mass="23022" checksum="DE5D340112B9C1BC" modified="2009-10-13" version="1">MSHALFNKTSPPFGPIVNGTNPLFSNINPMKALLGPLSFCEAFGYYGRVQAHSEPNIAGPFIMQNILILGTTRLIVATVYMTLGRSIRVFQIRDRIVIPPRPMTVFFVTVDLGCFVTQVFGSAAPASGDLKGIALGRALIISGLIVQLAALGLFLIITSVSRRLVRTSIADYKMTGMPSSSRYFQATYLVGGAMMSFMLSYTLESYFATLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z2Y3</accession>
    <name>C7Z2Y3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_87758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047277.1">
        <property type="nucleotide sequence ID" value="XM_003047231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z2Y3"/>
    <dbReference type="STRING" id="660122.C7Z2Y3"/>
    <dbReference type="GeneID" id="9676194"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87758"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87758"/>
    <dbReference type="eggNOG" id="ENOG502TAW6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002639_2_8_1"/>
    <dbReference type="InParanoid" id="C7Z2Y3"/>
    <dbReference type="OMA" id="HERECAY"/>
    <dbReference type="OrthoDB" id="5362512at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF9">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="200"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU41564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="732" mass="82706" checksum="D600D197F90E5D37" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z341</accession>
    <name>C7Z341_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_87817</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047479.1">
        <property type="nucleotide sequence ID" value="XM_003047433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z341"/>
    <dbReference type="GeneID" id="9676223"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87817"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87817"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="C7Z341"/>
    <dbReference type="OMA" id="GYRFNWA"/>
    <dbReference type="OrthoDB" id="9971669at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF53">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU41766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="55394" checksum="4A9A96E026C43385" modified="2009-10-13" version="1">MQFKDELQTPTSDIANGSIIGRDVDWTPEEEAAVRRKFDFTITPLVTLLYMLCAIDSTQGQCRVGYPQLFPHEWQRTDTHTSNARIEGMSDELNLVGYRYNILLTVFFIFYLASNIEAVPALVFCFGLVSLCTAFVESYASMLVVRAILGIFEGGAMPGTAFFLSCFYKKTELFFRMSIFIASSSLASSFGGLLAAGLSKIPPWGASAMLIHRWRNIFFFEGLITVLVAMAAPFLMPQSPGTYKFLTDRQRYIAAERLLRENAHVREEKVTWKHVRRAIFNIHTNVCAWCFFCTNSAVQGFGAFIPTILREFGWTSTEAQLKSVPPYLVACVVTIALGYLSDRTNKRGIFMAGILPCSIIGFSILRFSTNTDAKYAAVFLNAIACFGASSGFLSWGINNAGSPAVAAVAGGYMVMVGSMGGVLSTWTYLSRDSPLFHTGHTINLSLQCFCFCLACFGLAHCIYDNKLRARGGRGDRIQGLTEEEKLALGHRNPEFRYME</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z369</accession>
    <name>C7Z369_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Autophagy-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NECHADRAFT_53989</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047494.1">
        <property type="nucleotide sequence ID" value="XM_003047448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z369"/>
    <dbReference type="STRING" id="660122.C7Z369"/>
    <dbReference type="GeneID" id="9675926"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_53989"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_53989"/>
    <dbReference type="eggNOG" id="KOG0615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="InParanoid" id="C7Z369"/>
    <dbReference type="OMA" id="NSHAFDE"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14014">
        <property type="entry name" value="STKc_PknB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU41781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="222" mass="25053" checksum="280918B4FF2E1C86" modified="2009-10-13" version="1">MGYYTSKRTLYIAMEYFPKGDLGTYALEYAPLPEDECREIASQILRGLVTMHQERFAHRDVKPQNVLIQQSPRSVPPAPWWVKLADFGISKRLEPNTSGSTRRSGTLQYMAPELLRSRLSNRSNFNYPAVDLWALGVTTFFVLTKRLPFQDISSAIDYASDPDKPFPTAALNGCQVSMDAQAFICALMKPKPTERLDSGAAMRHAWMHSFLPEMQTTLSHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z3B6</accession>
    <name>C7Z3B6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_97871</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047518.1">
        <property type="nucleotide sequence ID" value="XM_003047472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z3B6"/>
    <dbReference type="STRING" id="660122.C7Z3B6"/>
    <dbReference type="GeneID" id="9675950"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_97871"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_97871"/>
    <dbReference type="eggNOG" id="ENOG502R80G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_8_1_1"/>
    <dbReference type="InParanoid" id="C7Z3B6"/>
    <dbReference type="OMA" id="PYIDITE"/>
    <dbReference type="OrthoDB" id="300709at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF11">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="20"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="183"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU41805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="301" mass="33767" checksum="3D3FA067A38F4A8C" modified="2009-10-13" version="1">MRHDPLFINKSSETSLNVSKILVVFGATGNQGSSVIRHVLQDPELSKTYTIRAVRRDPSSSRARDLASQGIEAVSGDPSNKTSLDSVFRGAHTVFAMTTSDYDGEAHKEIQYGKNLVDAAIAQCVKYHIWSTLPSPKVISSGKYTKVTGFDDKFVVEEYIRSKTSLMSAFYAPGSFMQNYATIMQPQPNPDKDGSYPETPESLWQRSLPNPRNSKVKHSRASIISATTGKGVKYVEVSEDVYKSFLPPTAQDELLRMMLYQQEFGYYGPQTEAEVAWFVENARRNPTTFKEFLRKHPLTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z3F0</accession>
    <name>C7Z3F0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_98226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698908">
        <property type="protein sequence ID" value="EEU41462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047175.1">
        <property type="nucleotide sequence ID" value="XM_003047129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z3F0"/>
    <dbReference type="STRING" id="660122.C7Z3F0"/>
    <dbReference type="GeneID" id="9675784"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_98226"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98226"/>
    <dbReference type="eggNOG" id="KOG0029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004498_9_0_1"/>
    <dbReference type="InParanoid" id="C7Z3F0"/>
    <dbReference type="OMA" id="NSHLVCF"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF410">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="51"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU41462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="482" mass="52659" checksum="E3BCC57D658795F2" modified="2009-10-13" version="1">MAKKTSEGFTWTPSTGLTDGLPTAGVVNSPRRIKLVQDAVCDVIVIGAGYAGLVASRDLSTQGKKSLLLEGRDRLGGRTWNASIDGFNYEMGGTWVHWQMPHIYREVSLYGLENDWVVRQNPGSREQLQLTHDDETTIYSRVLGLFCNADGDHLRHSWKYAFGTDQSPERVAKLDKMSCQDRLDEIRAQLSSNELAMLVAILQQMGGAEVGKIGYFSVIHWWVLGGHSVLGLNHMALHTRLGSGNSTLHRRIFDHAVSTGQLSYSFSTPVASIREADGVVTVQSRQGQAWRAKAVICTVPLNVLTSIQFEPPLPSAKVKAARQGQVNNCNKIHFDVKGPDLPWTSLASPGKGLVSAFGDGLTPAHNTGVVAFGPDPDAHNGIRLRDLCSVQAGLMHLAPEERGEVVVERIVSHDWNEDEFARGSWCIAPPEFATRKPGLPMLTGPTAGAAGSTERCRLVLKPLIRLPLHHVRHKGGRQSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z3M7</accession>
    <name>C7Z3M7_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_83304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046876.1">
        <property type="nucleotide sequence ID" value="XM_003046830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z3M7"/>
    <dbReference type="GeneID" id="9675460"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83304"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83304"/>
    <dbReference type="eggNOG" id="ENOG502RMTY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014491_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z3M7"/>
    <dbReference type="OMA" id="RIFIRYE"/>
    <dbReference type="OrthoDB" id="5035669at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="751"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU41163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="918" mass="103974" checksum="CFFD8492EC42AB90" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4B1</accession>
    <name>C7Z4B1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_70916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047162.1">
        <property type="nucleotide sequence ID" value="XM_003047116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4B1"/>
    <dbReference type="FunCoup" id="C7Z4B1">
        <property type="interactions" value="325"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z4B1"/>
    <dbReference type="GeneID" id="9675334"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_70916"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_70916"/>
    <dbReference type="eggNOG" id="KOG1685">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026457_5_0_1"/>
    <dbReference type="InParanoid" id="C7Z4B1"/>
    <dbReference type="OMA" id="PQRAYKN"/>
    <dbReference type="OrthoDB" id="10251727at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU41449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="42070" checksum="936E90548EEF0316" modified="2009-10-13" version="1">MAPSKELVAAGSTAVAAIDPDQTLKASKALLAHIKKASKQKADESGKRNLLDDDDEPTETPIWLTLTTKRHIADKARLQPGKIVLPHSLNTDETATICLITADPQRAYKDIVASEEFPAELSKRIARVIDYSKLKAKYSQYEAQRKLYSECDIFLADDRIINRLPKVLGKTFYKTTQKRPIPVSLQAKAPKVDGKRQKRVKTEGVVNAGTPAEIAKEIEKAIGAALVSLAPTTNTAVRVGYSGWTPKQIAENVDTVVTAMIDRWVPQKWRNLRSIYIKGPETTALPIWMADELWVDDNDVIAEDETTKTLKAEKANIGKKRKSLENTTEEAESPAPKKKAKKEKKVPEGDDDKLDKQISDRKTRLRKQKAKAKKAIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4H3</accession>
    <name>C7Z4H3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_91096</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046060.1">
        <property type="nucleotide sequence ID" value="XM_003046014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4H3"/>
    <dbReference type="GeneID" id="9678166"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_91096"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_91096"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_8_2_1"/>
    <dbReference type="InParanoid" id="C7Z4H3"/>
    <dbReference type="OMA" id="NHYSERF"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF122">
        <property type="entry name" value="NAD(P)-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="3">
        <location>
            <begin position="39"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU40347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="311" mass="33912" checksum="86DE25FA2D90ABA8" modified="2009-10-13" version="1">MSNNQEPVGYRAFDVTKTSHKKSYPAISPSKPSLSQAGKTVLITGGSGGIGFAIARAFGEAGAEKVIIVGREEAKVGSAAEKLKEQNQGSATVFEGRACQLADSESIDKLWDSLEAEGIKIDVIVLNAAMTGQFGPIERLGWKKVWKEFEVNVRSYHQFCERLHQNAKNQGGKRFIVNVSTSAIHDFPAASYAPSYSLTKNSATLLLQQIAREWKASDIQIVSFHPGALLTPGAMSLGLDEASLPWDDISLPASVAVWAASDEAAFLHGRFIWARWDVEELASGEIRERLESDEKFLRIGVHGLEEPKEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4Y5</accession>
    <name>C7Z4Y5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_91217</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG29 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU41006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046719.1">
        <property type="nucleotide sequence ID" value="XM_003046673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4Y5"/>
    <dbReference type="STRING" id="660122.C7Z4Y5"/>
    <dbReference type="GeneID" id="9678246"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_91217"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_91217"/>
    <dbReference type="eggNOG" id="ENOG502SGUN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_353388_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z4Y5"/>
    <dbReference type="OMA" id="RNPRICA"/>
    <dbReference type="OrthoDB" id="421951at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053858">
        <property type="entry name" value="Arb2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039113">
        <property type="entry name" value="ATG29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040666">
        <property type="entry name" value="Atg29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039362">
        <property type="entry name" value="ATG29_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40012">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40012:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22749">
        <property type="entry name" value="Arb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18388">
        <property type="entry name" value="ATG29_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Atg29 N-terminal" evidence="8">
        <location>
            <begin position="6"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Arb2" evidence="9">
        <location>
            <begin position="350"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="73"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="704"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="711"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU41006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="736" mass="81083" checksum="A80E50FEC3893FEC" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6Q3</accession>
    <name>C7Z6Q3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein kinase C-like</fullName>
            <ecNumber evidence="2">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">NECHADRAFT_103351</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2"/>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046445.1">
        <property type="nucleotide sequence ID" value="XM_003046399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6Q3"/>
    <dbReference type="FunCoup" id="C7Z6Q3">
        <property type="interactions" value="421"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z6Q3"/>
    <dbReference type="GeneID" id="9668720"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_103351"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_103351"/>
    <dbReference type="eggNOG" id="KOG0694">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_54_0_1"/>
    <dbReference type="InParanoid" id="C7Z6Q3"/>
    <dbReference type="OMA" id="QCTHLVP"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902660">
        <property type="term" value="P:negative regulation of glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903139">
        <property type="term" value="P:positive regulation of cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010606">
        <property type="term" value="P:positive regulation of cytoplasmic mRNA processing body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090334">
        <property type="term" value="P:regulation of cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000769">
        <property type="term" value="P:regulation of establishment or maintenance of cell polarity regulating cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070610">
        <property type="term" value="P:regulation of fungal-type cell wall (1-&gt;3)-alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060211">
        <property type="term" value="P:regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd20822">
        <property type="entry name" value="C1_ScPKC1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20823">
        <property type="entry name" value="C1_ScPKC1-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08689">
        <property type="entry name" value="C2_fungal_Pkc1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11620">
        <property type="entry name" value="HR1_PKC-like_2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05570">
        <property type="entry name" value="STKc_PKC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000101">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000103">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000014">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000034">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037778">
        <property type="entry name" value="C2_fungal_PKC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037312">
        <property type="entry name" value="PKC-like_HR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02185">
        <property type="entry name" value="HR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00742">
        <property type="entry name" value="Hr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="REM-1" evidence="23">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="REM-1" evidence="23">
        <location>
            <begin position="145"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="21">
        <location>
            <begin position="462"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="21">
        <location>
            <begin position="530"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="825"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="22">
        <location>
            <begin position="1085"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="72"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="353"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="602"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="14"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="199"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="19">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="366"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="617"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="668"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="738"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="754"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="768"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="794"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="854"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00068745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EEU40732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1150" mass="128251" checksum="93818D4F1671367C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z769</accession>
    <name>C7Z769_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_32451</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003046488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z769"/>
    <dbReference type="GeneID" id="9668244"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_32451"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_32451"/>
    <dbReference type="eggNOG" id="KOG2615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_54_5_1"/>
    <dbReference type="InParanoid" id="C7Z769"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="24"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="266"/>
            <end position="315"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU40821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="341" mass="37466" checksum="C9E07C2D012BEC6B" modified="2009-10-13" version="1">MGRSRHISAANRGQKQPPPFPTKQMFVLACCRICEPIAFMSIFPYIYYMIEDFNITDDSSKISVYAGMVTSAFTLAEFSTGVLWGRLSDKIGRKPVLLFGLLGTAISVLVFGFAPSLPVALFARALGGLLNGNIGVLQTTVAELVTVKEQQPRAYTIMPMVWCIGSIIGPMIGGALARPCISYPEIFARGTIWDRYPYLLPNLFSAATVFVGVIIGLLYLDETHAEKKTQRDRGREIGDYLAKLFGGVTKCNGRGRAPEKQALLDGERHVSYGSRHGSSSSDEEDEILPAYQSQESSPRLAPMDDTRSLQSQPLEPIVQEKPKTFTKPVIMNIISYGILAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z785</accession>
    <name>C7Z785_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_32656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046542.1">
        <property type="nucleotide sequence ID" value="XM_003046496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z785"/>
    <dbReference type="GeneID" id="9668955"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_32656"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_32656"/>
    <dbReference type="eggNOG" id="KOG2362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028286_7_0_1"/>
    <dbReference type="InParanoid" id="C7Z785"/>
    <dbReference type="OMA" id="VYTACRT"/>
    <dbReference type="OrthoDB" id="17255at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="MOSC" evidence="2">
        <location>
            <begin position="261"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU40829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="441" mass="49833" checksum="D3A403F3AEF6B2F1" modified="2009-10-13" version="1">MEATKGLLSSVDAVSLILLAVTLVAFLIPIFILFPPVPVDRSDVLNQTHSRVGVAPGGSNLRRQFSEEHRAREGRPPRVQGLYIYPVKSCRGIELERSKVLPTGLEHDRLYTFAYLKPPRAGKEDSPFWEFVTLRQLPLLANVKVDLWVPDPKKASRQLGTVDGAFLVVRFPWMDGGLRGLMQQASAKLSHGFQAVPEKEFLLPISFPDTEEIKARGYTFANVKIWNEVTTALNMDKELPAELAQYLGAKHQLGIFRMDPSQQREVFRCAQPKEALGYQPVVDFHDAVIQYPLHMLSLSSMQALDKNVVKDETMKQLDARRFRSNIIIAGNEEYDEDNWKVIHLKHATTGQECHFDVACRTVRCKLPNVDPDTGIRHKAEPDRALRKFRDVDEGAPKMGCMGMQMCPMFPGAAKPEQFQSFIEVGMDIDVVQRGHHVYICQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7S6</accession>
    <name>C7Z7S6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_93021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045592.1">
        <property type="nucleotide sequence ID" value="XM_003045546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7S6"/>
    <dbReference type="GeneID" id="9672492"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_93021"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_93021"/>
    <dbReference type="eggNOG" id="ENOG502S854">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139257_2_0_1"/>
    <dbReference type="InParanoid" id="C7Z7S6"/>
    <dbReference type="OMA" id="MDNDYKS"/>
    <dbReference type="OrthoDB" id="4357148at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="10906" checksum="2BB080B8FB11730B" modified="2009-10-13" version="1">MSSRSYEDAPSGEFQENSYVSRPGEKAEPIPVQADSDTVEDPIDANNADTDAQLERDDADAIDKSNIIDERTRGATKPGGTYEEPGDTEGLPDDTGRSSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z869</accession>
    <name>C7Z869_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_102602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045659.1">
        <property type="nucleotide sequence ID" value="XM_003045613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z869"/>
    <dbReference type="STRING" id="660122.C7Z869"/>
    <dbReference type="GeneID" id="9672431"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102602"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102602"/>
    <dbReference type="eggNOG" id="ENOG502SUQ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108553_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z869"/>
    <dbReference type="OMA" id="KCCGDAK"/>
    <dbReference type="OrthoDB" id="3520229at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="183" mass="18458" checksum="508CC60FC3CAF60E" modified="2009-10-13" version="1">MSTTTTTAAATATTACTNLYDSPNQDTTCAMPYTGNHTDIMKKCCGDAQIVSYHNDCGIYCVALDQTISDLADCLYENGAPWEAVFCSVPKSVSSSVASKTKDAAVPASAQASVISGGDDDKDSNDKDSDDSDSTASGTASSASSTSTGNAAAGIVPQSSVSTLGLTIGALLFSSMALGAFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8C0</accession>
    <name>C7Z8C0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gylcosyl hydrolase 115 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_39598</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045684.1">
        <property type="nucleotide sequence ID" value="XM_003045638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8C0"/>
    <dbReference type="GeneID" id="9672457"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_39598"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_39598"/>
    <dbReference type="eggNOG" id="ENOG502QTU7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004852_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z8C0"/>
    <dbReference type="OMA" id="GPRNYKW"/>
    <dbReference type="OrthoDB" id="4849794at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.520">
        <property type="entry name" value="Glycosyl hydrolase family 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031924">
        <property type="entry name" value="GH115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041437">
        <property type="entry name" value="GH115_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042301">
        <property type="entry name" value="GH115_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37842">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37842:SF2">
        <property type="entry name" value="GYLCOSYL HYDROLASE 115 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17829">
        <property type="entry name" value="GH115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15979">
        <property type="entry name" value="Glyco_hydro_115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002989027" description="Gylcosyl hydrolase 115 C-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="domain" description="Gylcosyl hydrolase 115 C-terminal" evidence="4">
        <location>
            <begin position="852"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1039"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1051"/>
            <end position="1063"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU39971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1063" mass="119857" checksum="32C1A3EB00B2035D" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8S6</accession>
    <name>C7Z8S6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_81614</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044735.1">
        <property type="nucleotide sequence ID" value="XM_003044689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8S6"/>
    <dbReference type="GeneID" id="9673314"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_81614"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_81614"/>
    <dbReference type="HOGENOM" id="CLU_101055_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z8S6"/>
    <dbReference type="OrthoDB" id="5061669at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF4">
        <property type="entry name" value="PROTEIN ALCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU39022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="255" mass="27586" checksum="90090A1745140688" modified="2009-10-13" version="1">MDYFRKVNGVSRNAAKVDEASLRTESRKMASSKQESGNPTPIATCGLFVAFGTLACQLLFAQNTVNIDSAAIPAHLFFGGFMITLGGALELCLGHYIPAMALVSLGLFCFPFNKTLLPAFSTATQGMVTDGAVSPTMEISTRFETSALILGMILLVYLVSSFRTNVALVLTIFSLDLGIVLTTSAYWLYGGHAVGELEVGKKMLFVGVNKRGWSLFYCRVRVQLLDFILDFAGSGRLSPVFACRGSGWKEDSLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8U0</accession>
    <name>C7Z8U0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_94393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044744.1">
        <property type="nucleotide sequence ID" value="XM_003044698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8U0"/>
    <dbReference type="GeneID" id="9673319"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94393"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94393"/>
    <dbReference type="eggNOG" id="ENOG502S67X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041445_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z8U0"/>
    <dbReference type="OMA" id="HINEVWD"/>
    <dbReference type="OrthoDB" id="3205825at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179">
        <property type="entry name" value="PROTEIN CBG02620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="273" mass="31931" checksum="A74FD00685DFE4BB" modified="2009-10-13" version="1">MIWLELLVCLIFAVICFLHLLGYIPPSFAFYFTILTTWALQVQFLLQIIVNRCSILLTDKRKAYRLKVGVAVLITAVNISVYNIWIPARLQISERYIWINEWWDRCEKVIYLLVDASLNLYFIHVVRVNLIVHGLTKYKRLTHFNMFIIGFSLSMDVLIITMMSLKNTFVYMQFHPLAYTVKLNIEMSMADLIGKIARDKHCGVISEGTFSSTISDGQYHLESLDQRSTTDSQRRLSGRDEFGFVSKPRRIFHCCTRRTGEFHREVPEEFPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8Z9</accession>
    <name>C7Z8Z9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_43650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTI2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU38914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044627.1">
        <property type="nucleotide sequence ID" value="XM_003044581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8Z9"/>
    <dbReference type="STRING" id="660122.C7Z8Z9"/>
    <dbReference type="GeneID" id="9672934"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_43650"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_43650"/>
    <dbReference type="eggNOG" id="ENOG502S3SJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024466_4_0_1"/>
    <dbReference type="InParanoid" id="C7Z8Z9"/>
    <dbReference type="OMA" id="HYHASQH"/>
    <dbReference type="OrthoDB" id="6417021at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110078">
        <property type="term" value="C:TTT Hsp90 cochaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018870">
        <property type="entry name" value="Tti2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32226">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32226:SF2">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10521">
        <property type="entry name" value="Tti2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="388" mass="43169" checksum="6AB5366BC98535C3" modified="2009-10-13" version="1" fragment="single">DLHGAILRAAGHLSAKETCDLQDGQIERLVEAINSKVLSAKNGTDSALLMEASLACLSVLSSKCSFVLDQDTRLKLIRVTDARDSWTTLISATTATELLARQLTEEELSDFIVGPVLQKTLRPLFSRHSSRITASGRPSQYSTAGDRSRMFEEVPTWKDEAPWAETAIQWAVNMSTPALIQQHWPLFTPVLLALVENESIDVKSRGLEILASFVAKCPGQVLQNTGIGRVFEDATFPMLLYLPSVTPEEQSTAVLSPAYDVLTTLAKSSEGFENPERRRLLDKALRNGIFAGHFHASQYSRIVQVLMQKTASVVNCLGIYSIKHLKVRRLYKIKKTPPDRTNLNKAPPFNDLVDHDRSFRDRASSHCCRCDTSIKRHYCQLLASNSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9H0</accession>
    <name>C7Z9H0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DOA4-independent degradation protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_70285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045217.1">
        <property type="nucleotide sequence ID" value="XM_003045171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9H0"/>
    <dbReference type="FunCoup" id="C7Z9H0">
        <property type="interactions" value="733"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z9H0"/>
    <dbReference type="GeneID" id="9673378"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_70285"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_70285"/>
    <dbReference type="eggNOG" id="KOG3230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069208_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z9H0"/>
    <dbReference type="OMA" id="KMAKMNQ"/>
    <dbReference type="OrthoDB" id="10252926at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="25386" checksum="41AF9BAE2F162DB9" modified="2009-10-13" version="1">MNILEWAFGKRMTPAERLRKNQRMLDKAIRELDQMRVKLEKQEKTLIQQIKTSAKNGQMGACKIQAKDLVRTRRYVEKFYAMRSQLQKISLRLQTYRTNEQMMQAMKGATMALGSMNKSMNLPQLQRIAMEFERENDIMEQRQEMMDDAIDDAMDVGIEEEGDEVVEQVLEEIGIDFNQALGETPTALGNAAVPEGKIAQAVGGGGGGDPVDDDLQARLDSLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAG8</accession>
    <name>C7ZAG8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_94702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045387.1">
        <property type="nucleotide sequence ID" value="XM_003045341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAG8"/>
    <dbReference type="GeneID" id="9672168"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94702"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94702"/>
    <dbReference type="eggNOG" id="ENOG502SIX4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072640_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZAG8"/>
    <dbReference type="OMA" id="WEGGVYE"/>
    <dbReference type="OrthoDB" id="5175824at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="2">
        <location>
            <begin position="38"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU39674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="254" mass="29023" checksum="07FA2568C4823C6A" modified="2009-10-13" version="1">MADEISELKRTVELLRNEVTRLSGRYSLNVILRRDSKAAVVELFSTSPEAYVQFLGGRYLTKEGVKRLYVDRFSKGFVQRNGPVHGFLLDHPQMQGIVDVEYGTRSDGTVALAKGRFRSLMQAGVHISQAEKHPRGFCQWFEGGIYENEYVKEADGKWRILRLRYFPFWHGDVEEGWSKKTSGFVPFPKKTFPEDPTGPDEVVSTDQQMLWPDTRVVPFHYQHPITGQQVKDEDMQAPAFGEPAKDALPALKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAQ1</accession>
    <name>C7ZAQ1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_55674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698913">
        <property type="protein sequence ID" value="EEU38884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044597.1">
        <property type="nucleotide sequence ID" value="XM_003044551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAQ1"/>
    <dbReference type="STRING" id="660122.C7ZAQ1"/>
    <dbReference type="GeneID" id="9672912"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55674"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55674"/>
    <dbReference type="eggNOG" id="ENOG502QT17">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023620_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZAQ1"/>
    <dbReference type="OMA" id="MRYPPAQ"/>
    <dbReference type="OrthoDB" id="5595695at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01299">
        <property type="entry name" value="Met_dep_hydrolase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057744">
        <property type="entry name" value="OTAase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="62"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="435" mass="48142" checksum="73B0F0F97BEC4451" modified="2009-10-13" version="1">MTEYTLHTSSLFDPKVKRVRKNVSVTVDSGTGLIVRVFERDDEKVTFSETMKVGDIDLRGRYVMPGLVDAHTHVFLHSYDEAGALQQKRDESMAERLIRGVNHCRTALLVGYTTYRDLGSEGMQEFDANLRDAIARGLTPGPRLFVATKVLASTGSFEPRTENTSGGHCLPAGADAVDGVEACRMAVRRRIAAGADIIKFFADYRRRIMRCPPAQQHPYIPSVLHPPKEPNPDYLVFSQEEMNMIVKEAALARAPVSAHCCTLEGALGAIEAGANTLEHVYFGTDDMFKKMVEKKVILVPTLAVAEKLHAHRFRDILKQVKRAHDLGVRLACGGDTGTYPHGDNVRELELMIEAGIPVVDVLESCTVGGWEACGGDMCGRRFGWFEEGLQADIVAFDEDPEENHKALRSVNFVMKDAMVRKRDGKPVGMCWGVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZB79</accession>
    <name>C7ZB79_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_45748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044359.1">
        <property type="nucleotide sequence ID" value="XM_003044313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZB79"/>
    <dbReference type="STRING" id="660122.C7ZB79"/>
    <dbReference type="ESTHER" id="nech7-c7zb79">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="9672863"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45748"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45748"/>
    <dbReference type="eggNOG" id="ENOG502RQNE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046066_1_2_1"/>
    <dbReference type="InParanoid" id="C7ZB79"/>
    <dbReference type="OMA" id="AFYGPDM"/>
    <dbReference type="OrthoDB" id="1263307at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF13">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="10"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="254" mass="28169" checksum="1DFD9287AE618F1F" modified="2009-10-13" version="1">MADDKQKPIIFLVHGAWHRPLHYRPLIHALQAKGFTVLAPPLASSGYDDSVDGKTYHDDVKRVHDVLLPFLDEGRIAIGIGHSYGGVPLTVAIQGHTVAERAAKGLKGGVASAIYISATPVIAKDISMYESVGNKYTTDWLHDEKRLPLKPDIASDAFYFDVEQSIRDEAMAHVCHQSRGPFEVPVVCTPKDLDIPKTYVVCLNDKIFLKDIQAYVADNWGAKPLEIESGHSPWLIDSHREWLVNLVEEEAAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBT3</accession>
    <name>C7ZBT3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_88659</name>
        <name evidence="7" type="ORF">NECHADRAFT_88947</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">77-13-4</strain>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698926">
        <property type="protein sequence ID" value="EEU36783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GG698916">
        <property type="protein sequence ID" value="EEU38465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042496.1">
        <property type="nucleotide sequence ID" value="XM_003042450.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044178.1">
        <property type="nucleotide sequence ID" value="XM_003044132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBT3"/>
    <dbReference type="STRING" id="660122.C7ZBT3"/>
    <dbReference type="GeneID" id="9669803"/>
    <dbReference type="GeneID" id="9670503"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88659"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88947"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88659"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88947"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_1_1_1"/>
    <dbReference type="OMA" id="HYSHISY"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF53">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010828729" description="FAD-binding PCMH-type domain-containing protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="66"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU36783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU38465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="503" mass="54491" checksum="FB045631D3BBC818" modified="2009-10-13" version="1">MLIKSVPVLVSLGLSARVVAQQYNTTSTGFKGCDALLDAGLEDILVFPEDVAYVDSVSTYYASENRRLRPVCIVQPRSTDHVSEAVRALSRASGAGNWDIAVRSGGHSDFDNNAVHRGVTIDLTFFNSIDLVKRDSVKWKGKSTLTKSIAQIRLGARWGEVMTYLENHNLGVTGGRSGHVGVGGLLVSGGASYHTQLWGLSCDNVVNYEVVLADGSVVEANARHNQDLFKALKGGGSNLGIVTRFDMRTFTTPPSGVYGGLLFTSWDHLNVVTKQFVEYASSIGSGNPDHQFVVYRADAGNLSLMAMAVSTDGNDDSPTFRAFSTIPLTRDLRKKQPLSSVAASIADTATTDMMNKAADIFVALTQDLRDADIPVSVNFVFQPLPKNLASVIPGNNLLDLDKNLPADSILFEARGTLAADDASYEGLVRAKMAQAIGELGAYSASKDGHSDYLYMNYANPEQDVIGSYGWENVMFLKKTAQRYDPTGFFQYRIPGGWKVNRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCE3</accession>
    <name>C7ZCE3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_77023</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698918">
        <property type="protein sequence ID" value="EEU38246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043959.1">
        <property type="nucleotide sequence ID" value="XM_003043913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCE3"/>
    <dbReference type="GeneID" id="9670393"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77023"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77023"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="InParanoid" id="C7ZCE3"/>
    <dbReference type="OMA" id="GPTFYKS"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU38246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="52706" checksum="21EB20CF0DAFC5F5" modified="2009-10-13" version="1">MGRGVFAGKAAFAQATPSLMIFCTIYALGSIFFGYDGASFGGVQAMDPFLKTFGKWNKEKEAYYLPSDLQSLMNSLPLIGKFLGTVIVGPIIERFVSLKPRGSPCEDWLTAIQVQVTSKNPAQFIVGRFMVYTAVGLVENVRLTPTSPSTAMCADRPQVVPTYQSEIAPGALRGLRSLIAGIVNESMSRKTDNSGWQIATALQALPAVIILCLLFFTPNSPRWLIFNDRYEEALKVLRIACAIMTFQQLTGVTFSSSYGPTFYRSVGLSDMAFVYAVVNNATSVVTAMMAMVFLDMFGRRTLVIHGGWSQGAFLIAIAALGRIKNPNVHESNGIVAGMQLYTCILHMTLGPGAYITAAEVGTQALREKTMAVSTALNVVVGFVVVFCTPYLLREIGSGLAYIWGGFAIITQGMLLFALFATFANHDQGRNLEEIDQLFEANIPAWKFNKYQTGGLTHELAVLENGETPGKMLDEEADIDRVENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCL5</accession>
    <name>C7ZCL5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Modin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_77093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698918">
        <property type="protein sequence ID" value="EEU38284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043997.1">
        <property type="nucleotide sequence ID" value="XM_003043951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCL5"/>
    <dbReference type="STRING" id="660122.C7ZCL5"/>
    <dbReference type="GeneID" id="9670323"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77093"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77093"/>
    <dbReference type="eggNOG" id="ENOG502SXX6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009106_2_0_1"/>
    <dbReference type="InParanoid" id="C7ZCL5"/>
    <dbReference type="OMA" id="EKVMGGW"/>
    <dbReference type="OrthoDB" id="5227693at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="587"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU38284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="722" mass="81995" checksum="D79929803C36BCB3" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCN2</accession>
    <name>C7ZCN2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_77111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698918">
        <property type="protein sequence ID" value="EEU38398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044111.1">
        <property type="nucleotide sequence ID" value="XM_003044065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCN2"/>
    <dbReference type="GeneID" id="9670436"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77111"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77111"/>
    <dbReference type="eggNOG" id="ENOG502T3T2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1061880_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZCN2"/>
    <dbReference type="OMA" id="PIDCELG"/>
    <dbReference type="OrthoDB" id="5098927at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002989014" evidence="2">
        <location>
            <begin position="22"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU38398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="280" mass="28957" checksum="6F10F771C51455AB" modified="2009-10-13" version="1">MVPRVGLLLAFSLVYIESSIAGPCIPGTTSTAVTSSEAESATSYSVSFTTVVTTDSTTSGTDSSTTSLTLTESSTESTTFVSSTSSAPVSSDSTTLLTSEATTSEATTSLSTQTSATSTSPQPDSTAFNIIPEAGSAASGFLKVRTILGGEVYFNNPYTSYQTGVFVVNGATRHLTERGSQSICAFFRTGQGYGDLIGCQPDVNPDVQQVPITCQLTASEKIQCSVAGKFCYYQGDMLHCDDRGSYSSLYIEGLSSDGYGVVLGPSGLSLSSVELSAVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDA9</accession>
    <name>C7ZDA9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein PBDC1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_48010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PBDC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698919">
        <property type="protein sequence ID" value="EEU38061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043774.1">
        <property type="nucleotide sequence ID" value="XM_003043728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZDA9"/>
    <dbReference type="FunCoup" id="C7ZDA9">
        <property type="interactions" value="645"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZDA9"/>
    <dbReference type="GeneID" id="9669886"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_48010"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_48010"/>
    <dbReference type="eggNOG" id="KOG4093">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103791_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZDA9"/>
    <dbReference type="OMA" id="IQFYAFE"/>
    <dbReference type="OrthoDB" id="10248897at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990593">
        <property type="term" value="F:nascent polypeptide-associated complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061770">
        <property type="term" value="F:translation elongation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3560.10:FF:000001">
        <property type="entry name" value="Protein PBDC1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3560.10">
        <property type="entry name" value="yst0336 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023139">
        <property type="entry name" value="PBDC1-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008476">
        <property type="entry name" value="PBDC1_metazoa/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021148">
        <property type="entry name" value="Polysacc_synth_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410:SF9">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04669">
        <property type="entry name" value="PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysaccharide biosynthesis" evidence="6">
        <location>
            <begin position="27"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU38061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="163" mass="18898" checksum="E183FB845D70C5CC" modified="2009-10-13" version="1">MDPLDSMAGGQIPKNFDAENAGNNEDIEKQFAVKAVQHMQTYWAILERVRGSTLRLTKIDDDIMEHLKEAFPEFDPAATVNEDEMKSKAGKERWRKFMMAYEKTVDDYNFGTMVRNSPKVEYEEDTAIFVPRMQFYALEIARNRAGLNDWIYEQAQAEKAKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDS6</accession>
    <name>C7ZDS6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mtf2-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_73168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043515.1">
        <property type="nucleotide sequence ID" value="XM_003043469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZDS6"/>
    <dbReference type="STRING" id="660122.C7ZDS6"/>
    <dbReference type="GeneID" id="9669735"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_73168"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_73168"/>
    <dbReference type="eggNOG" id="ENOG502S7AT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028481_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZDS6"/>
    <dbReference type="OMA" id="GPLYPAY"/>
    <dbReference type="OrthoDB" id="2444174at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043837">
        <property type="entry name" value="Mtf2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040009">
        <property type="entry name" value="Mtf2/C5D6.12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39468">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39468:SF1">
        <property type="entry name" value="MTF2-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19189">
        <property type="entry name" value="Mtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mtf2-like C-terminal" evidence="2">
        <location>
            <begin position="197"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU37802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="410" mass="46339" checksum="A95DA166ADB602F9" modified="2009-10-13" version="1">MSRNLLPFLYQTRTLQFACRRPVSLLVAQKASIVTQNRRSNRPDNSIPFEWDNQEEADSHTTPGQEGTLTPTESDIFKGIFDEIAQGRLPNAKKRPESAEGQTEHISEKPAKETSGEEFSEGSLIDQARSAQSDPDFLKQFPASLKNAAQAALGKFLLAPARPKLRDLTELDRAEARQMRVAAQFEKFREKDKLRVETLMKACKTDVELWKLMEDEVFSLPTKLMLEIDKHKERKERKKAKMAVRRAAKKGIILEEPRVMDIHGPLYPHYLSTGMKLLDTAFLKPSALALNILPQVKDLGLSSYVLGVSTPLYAKLADIYWKRYGDATAALDALDEMQSVGLHPNEEVEKLVEEISSHLHSCTWGAQGPFVMAMTDSPPYDASLTSRLDRWERIIAKSRPRQPEPEPELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZE18</accession>
    <name>C7ZE18_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_88286</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043655.1">
        <property type="nucleotide sequence ID" value="XM_003043609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZE18"/>
    <dbReference type="GeneID" id="9669756"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88286"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88286"/>
    <dbReference type="eggNOG" id="ENOG502QU7F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043560_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZE18"/>
    <dbReference type="OMA" id="QAFIGFC"/>
    <dbReference type="OrthoDB" id="409948at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47567">
        <property type="entry name" value="MITOCHONDRIAL SUBSTRATE/SOLUTE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47567:SF1">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="178"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU37942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="38638" checksum="372E18A7ECEA0587" modified="2009-10-13" version="1">MVTSDPESSRGTTEHSPLLGDRPPQVQGEGSESGAEPEPTPEEKTPRRRYAWRIFWILLLLIVIGVFVKGWIDADETDFDLKGALKRALGGGLSGAAAMVLQVLLLMPLRTIMNYQYRHGTSFTIATRTLYEEGGIRRYYQGISPALVQGPVSRFGDTAANAGILALLQSNPYLKTLPSPIKTIFASLCAAAFRMILTPIDTLKTTLQAQGARGTALLRRRIKSNGIGSLWWGAFATAAATFVGHYPCQQYNFLSEVIAEPAKHPLFWWLLRLAFIGFCASIVSDSISNSLRVVKTYRQVNDTKVSYGEAARAVVVQDGITGLFGRGLKTRILANGLQGILFSILWKLFLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEK8</accession>
    <name>C7ZEK8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_53594</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698921">
        <property type="protein sequence ID" value="EEU37614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043327.1">
        <property type="nucleotide sequence ID" value="XM_003043281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEK8"/>
    <dbReference type="GeneID" id="9669312"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_53594"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_53594"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_11_0_1"/>
    <dbReference type="InParanoid" id="C7ZEK8"/>
    <dbReference type="OMA" id="RTITAMW"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="487"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="66"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU37614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="546" mass="60767" checksum="4FBAA4DB50936895" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZF62</accession>
    <name>C7ZF62_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_86403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043226.1">
        <property type="nucleotide sequence ID" value="XM_003043180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZF62"/>
    <dbReference type="GeneID" id="9665341"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86403"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86403"/>
    <dbReference type="eggNOG" id="ENOG502SHTH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043706_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZF62"/>
    <dbReference type="OMA" id="MHICEPW"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU37513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="433" mass="49147" checksum="3FA46620FDC916CD" modified="2009-10-13" version="1">MVQTAPYTSANYPRKTCSHYSDDGVLRDALDKLIRNHWRKLGARLVSSPSTKLLEYHVPSSFDENYVLFNWSSTANAESIRKVEELSSFLSPSQNISFLPSMDVIDKLFRPADWPFERKNEPPDAPLLYVHLTIFSDASVVAMSCPHVLADQFGVASIVKAWLKVARREAPPDMLGYRDDVLPPGHPIFDYIDKESRKGMMRARGKRDQTAVMAGIVLDLVKAREEESHIAFVPAQLVERLRKRTSKVLAEKNESVPDISNGDILTAIFTKMTRHDRSEYSLNLSQTVNLRGRVPGLWDDDGDRFIHNALHYATSNLKISASTPLHEIALSNRQAINKALERSEIEVGLAALRDVSKRRQVMLICEPFEKLYSVSNWCGAWKGIEFSAAEKEPQVKREHAWDMLVLGQKPRISSLRRKRTFVIRNGEHHSSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFC1</accession>
    <name>C7ZFC1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_67867</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698923">
        <property type="protein sequence ID" value="EEU37315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043028.1">
        <property type="nucleotide sequence ID" value="XM_003042982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFC1"/>
    <dbReference type="STRING" id="660122.C7ZFC1"/>
    <dbReference type="GeneID" id="9665074"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_67867"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_67867"/>
    <dbReference type="eggNOG" id="ENOG502SJK8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011915_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZFC1"/>
    <dbReference type="OMA" id="QYWEVAN"/>
    <dbReference type="OrthoDB" id="5376052at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TF_fung"/>
    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF28">
        <property type="entry name" value="C6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="118"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU37315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="744" mass="83079" checksum="DA31C4AEC242FF7A" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFH5</accession>
    <name>C7ZFH5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_37222</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698923">
        <property type="protein sequence ID" value="EEU37152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042865.1">
        <property type="nucleotide sequence ID" value="XM_003042819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFH5"/>
    <dbReference type="GeneID" id="9665144"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_37222"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_37222"/>
    <dbReference type="eggNOG" id="ENOG502QTZH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025894_2_0_1"/>
    <dbReference type="InParanoid" id="C7ZFH5"/>
    <dbReference type="OMA" id="PRQAFIS"/>
    <dbReference type="OrthoDB" id="10027823at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520:SF5">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="94"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="228"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU37152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="50200" checksum="9FB86E129E39264C" modified="2009-10-13" version="1">MGLWNLATGFFSSIGAGALWRSSRDLKILILLRFVRLLGYGGTTFVLALYLNALGFEDTQIGLFMTLTLVGDLAISFVLTYVGDRMGVRVTAAIGAMLMCAGGGAFVFLDNFWLLLLASIVAVINPSANEIDPFKAVEESAIARLSTPETCNDMFAWWSMLGMFGTAASNLLTGWVIDALEVSGVEKIDCFRIIFLGYAGIGVLKLFCSLLLSSEVEHVAIEKESCSSPASSQYEGDDEEQSETEPLLSGNSPDYGAASSRTISSSSTASQEKRLFTPSSFSFIWKLSVAMAFDFVGSGLAQISWMTYFFKREYDIPEGALGSATFTAGIISSVLNLASSPLSRAIGQVQTMVLCHTINSISLLMVSVPGNKYVALVIFIFRIVTREIDNAPRQSFISAGVLDHERTSAMGVINIVKTVGSCLGLYVTGLFAGLDQFWLAFIVAGALKLVYNVLILVFFWRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFS0</accession>
    <name>C7ZFS0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_86654</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698924">
        <property type="protein sequence ID" value="EEU37086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042799.1">
        <property type="nucleotide sequence ID" value="XM_003042753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFS0"/>
    <dbReference type="GeneID" id="9664823"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86654"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86654"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_0_1"/>
    <dbReference type="InParanoid" id="C7ZFS0"/>
    <dbReference type="OMA" id="IVWTIAN"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF3">
        <property type="entry name" value="HEXOSE TRANSPORTER PROTEIN (AFU_ORTHOLOGUE AFUA_8G04480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU37086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="26159" checksum="ECA806FA3DF440F4" modified="2009-10-13" version="1">MTSPSLRIPTILRMKYLTYYLSIILNSVGITSVTHQTLISACLELWNPFWSMLAALNVDRLGRRMLFMSSHTDSLYLGNRHASSLQHHHRVIWKLRVYLRLYYFFGYDIALTPLVVSYPIEIWPYNTHAKGLALTQVVSLGFTFFNTFVNPIALDAIRWKYYFVFLTTIIVMIFVLWFYYLETCSLTLENVALLFDGDSAHVGVATAENAIKTSYAKHQHVEEPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFT6</accession>
    <name>C7ZFT6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_52113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698924">
        <property type="protein sequence ID" value="EEU37093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042806.1">
        <property type="nucleotide sequence ID" value="XM_003042760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFT6"/>
    <dbReference type="GeneID" id="9664922"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_52113"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_52113"/>
    <dbReference type="eggNOG" id="ENOG502SNY8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069188_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZFT6"/>
    <dbReference type="OMA" id="GRNCYRW"/>
    <dbReference type="OrthoDB" id="5207784at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU37093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="230" mass="25499" checksum="0A55AC45368F2217" modified="2009-10-13" version="1">MDADSTISVLRPSIDDTSGPNTLVLSGQSIYSENAASIPLYQLNREVTSTSQKGSTVIFERVEYDGPGEAESMASIKQRNRHLFYLVHPANAQYRTDLPAYYITSASPDVVGNVQLQASKSLLQKVEFKAFLSAGKTSSSDKLFNEDSQEILFEVKPKWKGGQYQWIDSAGKKIAHEEGKGEHKLVISLPIPQQTKDALVALWALKIWHDTLETRAAKREGKLKCAILND</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFU4</accession>
    <name>C7ZFU4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_52111</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698924">
        <property type="protein sequence ID" value="EEU37007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042720.1">
        <property type="nucleotide sequence ID" value="XM_003042674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFU4"/>
    <dbReference type="STRING" id="660122.C7ZFU4"/>
    <dbReference type="GeneID" id="9664836"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_52111"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_52111"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_6_16_1"/>
    <dbReference type="InParanoid" id="C7ZFU4"/>
    <dbReference type="OMA" id="CQATETG"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="8">
        <location>
            <begin position="57"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="702"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="742"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="787"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="828"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="880"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="932"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU37007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1090" mass="122353" checksum="667AFA452C509801" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFV9</accession>
    <name>C7ZFV9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_86743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698924">
        <property type="protein sequence ID" value="EEU37045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042758.1">
        <property type="nucleotide sequence ID" value="XM_003042712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFV9"/>
    <dbReference type="GeneID" id="9664874"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86743"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86743"/>
    <dbReference type="eggNOG" id="ENOG502QZKU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066482_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZFV9"/>
    <dbReference type="OMA" id="NAKWFER"/>
    <dbReference type="OrthoDB" id="3596450at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF1">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="6"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="357" mass="41295" checksum="8FE63B0C2F8B60D4" modified="2009-10-13" version="1">MDFCNFHPFPRLPTELRVQIWETCLRPSQRHRPGLHYCTIGNDRRLVPLSWGKFTRLEKHSRASPDHRSACLWHAGLWAACKESRSVIMEHYQLKEWNEYLEIGPPKRSVPEYYYADGGSRKEILPPSMITVREGHNESYLTVYPTRDIFCVTSDSCESAFWSGERRNINHSLHYATTTSRSLGVQNFAVEFDPSWNRFFPDKIYTLKEERSARGYLARMLEDLAGCLFWTKLWLIDKHVRWSASPGKEVGPVFYDYDCEYVQIDVSDTLPDPNSGANESPVACFIRRLGELGDRDYTGRYMLAVDDEADPGFWAEEPSPFLVKEWVRILVRRDNQVTGGIDGLIQSMSSGRDIEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZG50</accession>
    <name>C7ZG50_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyoxalase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_52249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698924">
        <property type="protein sequence ID" value="EEU37018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042731.1">
        <property type="nucleotide sequence ID" value="XM_003042685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZG50"/>
    <dbReference type="GeneID" id="9664847"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_52249"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_52249"/>
    <dbReference type="eggNOG" id="ENOG502S4CM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058475_0_1_1"/>
    <dbReference type="InParanoid" id="C7ZG50"/>
    <dbReference type="OMA" id="ENTIVDW"/>
    <dbReference type="OrthoDB" id="408973at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025870">
        <property type="entry name" value="Glyoxalase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40265">
        <property type="entry name" value="BLL2707 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40265:SF1">
        <property type="entry name" value="GLYOXALASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13468">
        <property type="entry name" value="Glyoxalase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase-like" evidence="1">
        <location>
            <begin position="11"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="275" mass="29810" checksum="A2C1B1B8079DD6A1" modified="2009-10-13" version="1">MADNTSVRPILDHIVILISYETLQELPKRLEGALTVIDGGTHADGRTLNKLILFSDGVYIELIAFQQNLDPERRKSHRWGELEEGTVIDWAHTLPDEKNFAVIQKRVKDATSGASYRDPVAGGRIRPDGVELKWSVASAQDASSNPLHPGTAPFWCLDRTPRHLRVPYQGDQGASSTKHPSGALGVSRVSVTVSESELDVIAGVYDGIHGPASDTGADGKVWSYVVHSGSTQGKHQLSLGKSSDQKRHIHITLLGDENSPSTIEVLPGLTFGIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZGY6</accession>
    <name>C7ZGY6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_51917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698927">
        <property type="protein sequence ID" value="EEU36690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042403.1">
        <property type="nucleotide sequence ID" value="XM_003042357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZGY6"/>
    <dbReference type="STRING" id="660122.C7ZGY6"/>
    <dbReference type="GeneID" id="9669643"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51917"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51917"/>
    <dbReference type="eggNOG" id="ENOG502S8TM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102622_1_1_1"/>
    <dbReference type="InParanoid" id="C7ZGY6"/>
    <dbReference type="OMA" id="IETHERC"/>
    <dbReference type="OrthoDB" id="5362512at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="88"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU36690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="188" mass="21089" checksum="723DB0AA53907FA4" modified="2009-10-13" version="1" fragment="single">MEGADTDKLKETTHPWDIVGTGTHVCAEANSPESWDMVHGWIQQCVDNHNECRRGSEDRPFPTRILDVGSEGNSPRLCVPNSDERGKYAALSHCWGDVMPLKTTKSTLNEFCRGIDLSRFPQTFKDAIVACQKLQIRYLWIDSLCIIQDDEDDWAVQSPKMSDVYQNAYITLAAAAAQNSTEGCFVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZH04</accession>
    <name>C7ZH04_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">NECHADRAFT_86554</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GG698927">
        <property type="protein sequence ID" value="EEU36726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042439.1">
        <property type="nucleotide sequence ID" value="XM_003042393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZH04"/>
    <dbReference type="STRING" id="660122.C7ZH04"/>
    <dbReference type="GeneID" id="9669679"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86554"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86554"/>
    <dbReference type="eggNOG" id="ENOG502RAD0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1004908_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZH04"/>
    <dbReference type="OMA" id="VYEMGTH"/>
    <dbReference type="OrthoDB" id="3065412at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF2">
        <property type="entry name" value="GPI ANCHORED CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G10580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 18" id="KW-0732">Signal</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002989146" description="CFEM domain-containing protein" evidence="18">
        <location>
            <begin position="23"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="19">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="110"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="256"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EEU36726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="324" mass="33080" checksum="3102D1180B355F8C" modified="2009-10-13" version="1">MTLAKKTTLLLAACTWIAITEAQNTLPVLPSCATSCLSTFDGDSPSANTTCSTLDIKCICQDAPYLDSMICCLHEACSNSDRESAEAYSRSLCKSLGVTMPSGLGCSTNTSSSATGKATSADGISIPTESSGTSSDSNTGAGGSSSENSSGSDYGSSSSHHKIHHSSKAGLGAGLGVGLPAAAALIGGILYRLRRKKNAPTAPPTAPNLTNGINELPAGSNPPHFQPQPQPVGTYPQAGLAAYGAVEEKYTSQMGVTAASSPVHELPPQHQPQSGLPPYASPPVHELPLTGWQQPELPGSTVPPVHELPLNPHLNPGPPGSQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHM0</accession>
    <name>C7ZHM0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_42474</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698928">
        <property type="protein sequence ID" value="EEU36437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042150.1">
        <property type="nucleotide sequence ID" value="XM_003042104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHM0"/>
    <dbReference type="STRING" id="660122.C7ZHM0"/>
    <dbReference type="GeneID" id="9669334"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_42474"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_42474"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_3_1"/>
    <dbReference type="InParanoid" id="C7ZHM0"/>
    <dbReference type="OMA" id="QRHDFHM"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000115">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF238">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01680)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU36437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="426" mass="47155" checksum="715617E99655AF9F" modified="2009-10-13" version="1" fragment="single">AVQLDVAIVGAGLSGLGVAIASALSGHRVIVYESATELREIGAGLQLTPNSTKILQRWGIAEGLLKAAAEPTSLIVHRYTGKILAEEANFDEKIRARYGAPFIDMHRVDLQMALFDRAKELGVRFEMGQKIADVDFSTPEISTASGHKVRADLIVAADGIWSQCRACFTGNGDPPKPTGDLAYRLVIDLEKVTDADLRLWISKPKVHFWIGPGAHVVGYSLRGGNQYNIVLLVPDDLPQGVSRQAGSVKEMRELFKNWDPTLNRFLDLVDGVEKWKLMHRSELPSWVNDEGNFVFVGDACHPMLPYLAQGANSAIEDGAVLGLLLGTLSRREDLPKALRRYQQLRKARGDSIVKETFKQRDSFHMPDGPEQEARDAIFLSQLGKELRAPFPSRWTCPEVQPWLYGYDAFKEVQESIKVDPIGQGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHZ8</accession>
    <name>C7ZHZ8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polysaccharide lyase family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_52708</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698929">
        <property type="protein sequence ID" value="EEU36368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042081.1">
        <property type="nucleotide sequence ID" value="XM_003042035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHZ8"/>
    <dbReference type="STRING" id="660122.C7ZHZ8"/>
    <dbReference type="GeneID" id="9674417"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_52708"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_52708"/>
    <dbReference type="eggNOG" id="ENOG502QR5B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021894_0_1_1"/>
    <dbReference type="InParanoid" id="C7ZHZ8"/>
    <dbReference type="OMA" id="ATWGVEG"/>
    <dbReference type="OrthoDB" id="1637350at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF18">
        <property type="entry name" value="PECTATE LYASE 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002989290" evidence="5">
        <location>
            <begin position="18"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate lyase" evidence="6">
        <location>
            <begin position="46"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU36368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="344" mass="38056" checksum="D2A5DC9EA66DDE50" modified="2009-10-13" version="1">MNLKLFLFYFFAGLAFAFPSDYLKLATWGLEGYAKDNPIGPTTGGKGGKTVFVSTAEQLVAAVAGTDPKIVRVKGKITLPARLKVGSNTSLIGVGASAHITGKGVDVFNGDNVILQNLKISHILDNDCITIRNSTRVWVDHNEFFSDISYGPDHYDGQVDIIRASDFVTVSWNYFHDHWKSSLVGNDATFRDLDSGHLHITYHHNYWRNMGTRGPAARFGRLHGKFSFHDFYNNLYEDFLYQAIHSRSDNQVLVEGNVFRGNTSEALSTYGLVIPMDSPNTCTCGDEELDGYANLGAKNDWGSAGVNITQKGTFYKADYKYKLTPLKLVPTVNKLGAGVGRIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZIW1</accession>
    <name>C7ZIW1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_53114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698931">
        <property type="protein sequence ID" value="EEU36095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041808.1">
        <property type="nucleotide sequence ID" value="XM_003041762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZIW1"/>
    <dbReference type="STRING" id="660122.C7ZIW1"/>
    <dbReference type="GeneID" id="9674135"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_53114"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_53114"/>
    <dbReference type="eggNOG" id="ENOG502RZMU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042688_3_1_1"/>
    <dbReference type="InParanoid" id="C7ZIW1"/>
    <dbReference type="OMA" id="KPWAKVD"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF4">
        <property type="entry name" value="7ALPHA-CEPHEM-METHOXYLASE P8 CHAIN RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU36095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="34035" checksum="169CA0778914C741" modified="2009-10-13" version="1">MTTGVFKYIDPASSVGADGSHVKPWSKVDVDQTSFKRTEKKRSVINIREAARSTPFGVDVSGFDVFTSPAKETAFTDDEAVREGYYAEVEELLRKRIPGIKKVVIFDHTIRKREKDSARQPVQQLHVDQTPGAAEVRVRRHIEDPAEAEELVKGRYQIINVWRPIGHAATDFPLAVVDWRTTQPEDLISVDLLYPQRKDGDDNDDRGKEVRPDESTFTSTEGYEVRGETYAIAPSDKHKFYYAKDMTPEEVMLIKCFDSRSQGLPGGKEGLAGLTPHTAFVDPATPADAKGRQSIEVRCLVFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJZ2</accession>
    <name>C7ZJZ2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_87986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698936">
        <property type="protein sequence ID" value="EEU35676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041389.1">
        <property type="nucleotide sequence ID" value="XM_003041343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJZ2"/>
    <dbReference type="GeneID" id="9676261"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87986"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87986"/>
    <dbReference type="HOGENOM" id="CLU_1267195_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZJZ2"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU35676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="218" mass="25199" checksum="065648BBEC0EF046" modified="2009-10-13" version="1">MDDIAVSSLNKGTNKNDVNGWLWEPVNSGKVLSFPSGVATGRRKWISDYFNVDAKSGRMDLYWNSLKDVAKDEDPVLRRQWRSDGLADYVWTQSVDDAVRVWLNQYPKAGAIVAWLNSCAEDDLAPELILIDTPPWATEPPVVCDDWFGNIDKRVTDGFNDQKLGKDDYNHKVRYRVQWRKGCKTELNGRKDMDVLNPVEDYSVRWRNAFQMPWEYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKK4</accession>
    <name>C7ZKK4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methylmalonate-semialdehyde dehydrogenase (CoA acylating)</fullName>
            <ecNumber evidence="2">1.2.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_51256</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.27" evidence="2"/>
    <dbReference type="EMBL" id="GG698940">
        <property type="protein sequence ID" value="EEU35423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041136.1">
        <property type="nucleotide sequence ID" value="XM_003041090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKK4"/>
    <dbReference type="STRING" id="660122.C7ZKK4"/>
    <dbReference type="GeneID" id="9675818"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51256"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51256"/>
    <dbReference type="eggNOG" id="KOG2449">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_10_1"/>
    <dbReference type="InParanoid" id="C7ZKK4"/>
    <dbReference type="OMA" id="VEYATYV"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000002">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase (Acylating)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000003">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase [acylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="MALONATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866:SF3">
        <property type="entry name" value="METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="37"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU35423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="521" mass="56247" checksum="0DA92E476B5EF31F" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKY6</accession>
    <name>C7ZKY6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="10">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_59526</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="10"/>
    <dbReference type="EMBL" id="GG698942">
        <property type="protein sequence ID" value="EEU35316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041029.1">
        <property type="nucleotide sequence ID" value="XM_003040983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKY6"/>
    <dbReference type="FunCoup" id="C7ZKY6">
        <property type="interactions" value="809"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZKY6"/>
    <dbReference type="GeneID" id="9675507"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_59526"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_59526"/>
    <dbReference type="eggNOG" id="KOG0524">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012907_1_1_1"/>
    <dbReference type="InParanoid" id="C7ZKY6"/>
    <dbReference type="OMA" id="WYANCPG"/>
    <dbReference type="OrthoDB" id="10266385at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000006">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB_mito-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006667">
        <property type="entry name" value="PRK09212.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008854">
        <property type="entry name" value="PRK11892.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624:SF96">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="9 10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="11">
        <location>
            <begin position="61"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU35316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="387" mass="41593" checksum="198C47AF9023E57A" modified="2009-10-13" version="1">MSRILRPAARLAASTRVLRAPATTSFAQSAAARAALARPVLFGSSQTRSYAEGSGSGVKEVTVRDALNEALAEELEANPKVFVLGEEVAQYNGAYKVTKGLLDRFGDQRVIDTPITESGFCGLAVGAALSGLHPVCEFMTFNFAMQAIDQVINSAAKTLYMSGGIQPCNITFRGPNGFAAGVGAQHSQDYSAWYGSIPGLKVVSPWSAEDAKGLLKAAIRDPNPVVVLENELMYGQAFPMSEAAQKDDFVIPFGKAKIERSGKDLTIVSLSRTVGQSLVAAENLKKKYGVDVEVINLRSIKPLDVETIIQSVKKTHRLLSVESGFPAFGVGSEILALTMEYAFDYLDAPAQRVTGSEVPTPYAQKLEEMAFPTEQLIEDYAAKLLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLH0</accession>
    <name>C7ZLH0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_88674</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698945">
        <property type="protein sequence ID" value="EEU35135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040848.1">
        <property type="nucleotide sequence ID" value="XM_003040802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLH0"/>
    <dbReference type="GeneID" id="9679281"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88674"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88674"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="C7ZLH0"/>
    <dbReference type="OMA" id="FILSMWY"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF54">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU35135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="50268" checksum="062427FC41AA1440" modified="2009-10-13" version="1">MNTKTAIASEDELRHGGSSAESMDSSEYDRFCLLRESFTEEKQAALIRKIDFRILPPLVLVYLLAYIDRSNAGNAKLFGALEDLGLSGQQWNVSLAVFFITYAAGGVPSNITLKRVGPRFWLPSLLIGCGSTIICSGVQSTYAGWISFRLILGIIEAGYRGWRLIYVLEGLFSVVVGVACFWLINPVPAKVTGWLTDKEREYLVLRNRFAVGGESGIKEREDFNMADVKKAFRSIHTYSVALTEFTVAVVVYRISFVLPSIVQSLGYSSVKAQAMTAPPYIFACVVTIISDLAADRYRQRALSIILPNTMAVVGFVIITITIRYHQIPGVTYFGLFLMAGGLYPISPAVMAWVALNMAGSMKRAAGLGLMMSLAQLGGIVGSNIFMPDEAPVYSTGFGICIAMLTAFGVIWPGIYYLILKRINSRRAAIPVEEVMTKYTPEQLTDMGDESPLFRYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLM3</accession>
    <name>C7ZLM3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_8545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698946">
        <property type="protein sequence ID" value="EEU35088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040801.1">
        <property type="nucleotide sequence ID" value="XM_003040755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLM3"/>
    <dbReference type="STRING" id="660122.C7ZLM3"/>
    <dbReference type="GeneID" id="9679233"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_8545"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_8545"/>
    <dbReference type="HOGENOM" id="CLU_102622_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZLM3"/>
    <dbReference type="OMA" id="SGLEYAC"/>
    <dbReference type="OrthoDB" id="5362512at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="57"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="142" mass="16074" checksum="6F6B53F5D37153DE" modified="2009-10-13" version="1" fragment="single">LSCMRFWMQQCLTQHDQCRVANPEGWLPKRLLDVGLDFSSSTIRLLGSEDVSAGSSYTTLSHRWNTAQMPKLTSNHPVDFDIDSLPYTFQEAIETTRGLGLRYLWIDSLCINQNDPDDWEAQSAQMSMVYENSICNFAATGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLN3</accession>
    <name>C7ZLN3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_44774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698946">
        <property type="protein sequence ID" value="EEU35094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040807.1">
        <property type="nucleotide sequence ID" value="XM_003040761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLN3"/>
    <dbReference type="STRING" id="660122.C7ZLN3"/>
    <dbReference type="GeneID" id="9679237"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_44774"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_44774"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_40_1"/>
    <dbReference type="InParanoid" id="C7ZLN3"/>
    <dbReference type="OMA" id="AYCDQEL"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="288" mass="33010" checksum="2BD62EFE56CCDBB9" modified="2009-10-13" version="1" fragment="single">MDNDQLIQQWELEVKEINDTFTCHPSQQRWTTDERWERLEMLGRGGYGEVWLQKCTTGPRVGDLRAVKELSKMSRQSSEHTSNKFCYQELSALIKFSHQQSLFITMQYFPLGDLQSHITRPLPDGEASTITRQLLRGLSFMHENKFAHRDLKPANILVQEKGPSWWVKLSDFGCSKEATTLRTTVGTPPYWAPELCHIFTHADEESSDCIVDRAYSFEVDIWAVGVIAFRLTTGALPFGDNPYSKLYRYVRQSAPFPTSSLLTNESKSFSEWLMSRSPGDRPTTAQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZML0</accession>
    <name>C7ZML0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_82413</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698953">
        <property type="protein sequence ID" value="EEU34791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040504.1">
        <property type="nucleotide sequence ID" value="XM_003040458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZML0"/>
    <dbReference type="GeneID" id="9678902"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82413"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82413"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_647399_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZML0"/>
    <dbReference type="OrthoDB" id="5061285at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF83">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU34791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="424" mass="45986" checksum="A7C63590AF382950" modified="2009-10-13" version="1">MSRLSSRADSIFDNARTSGNLSYKFCSAAAAVKTADEQTTVTTRDGQTFKARHVVVAVPLNCLKDIAFESGLDPVKAEAIGRGQSNDAYKVCVEASEKEWRNWSGHAFPDKGISVLIGDASPHPETHILSTFTSLPVLAASTLLVSLSLGSYGVLSLTYAMEVSPLPLRGVLGAFYGFGIITRPLLAAGVAQGVISFAITWAWPLVLLPVSLFASESPVWLTRQGRIADAEAALQRLAISDFNIGTDLVLAGVDAETSFLWSLGAGLGALLGAFISLWILAKCLRRPVYIWYQLLSTGLLFILGFIQLDFKYYERRDGVFAQGALMTIWNIFYGAVLSPVSTVIMGEVPSNALRSKTVEFATAVQVFMSVLVLTIYPYLLNPDSGHLQGYIRCEKHVESFDSKARLWDKEKGPEGVQSCIVVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZN96</accession>
    <name>C7ZN96_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_15701</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698964">
        <property type="protein sequence ID" value="EEU34519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040232.1">
        <property type="nucleotide sequence ID" value="XM_003040186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZN96"/>
    <dbReference type="GeneID" id="9678055"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_15701"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_15701"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZN96"/>
    <dbReference type="OMA" id="WHIMPLC"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU34519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="38353" checksum="322254B783B92881" modified="2009-10-13" version="1" fragment="single">MKDRALLSSDEEKKLLRRVDFRLMILCAIIFMIKNVDANNAANARIMNKDTDRNIMTQLNMTADDYNWVSTVYNVTWGLVLACHAAVKSSAGLLTARFFLGVAESGMFPGIILQMSYWYRADEMTPRLLIFCAGMNGRHGLSGWQWFFLVEGVVTIGFGVLLFFIFPDFPAQAKWLTDKEKRFLQARLPPNAPRSSEANFKASEIWDTMKDQRLWWFAFIWASKTIGSTGLSFYLPTIVASLGLASIAESQLLTIPSSVLAIILIAFSSYLTNSLAVPYPAVALVYLISNLACYGVMVAYPNNGGVYAATLIAAGVSLAWFATMWPWRLQTTFRATGSAFAIAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZP00</accession>
    <name>C7ZP00_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_85425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003039862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZP00"/>
    <dbReference type="STRING" id="660122.C7ZP00"/>
    <dbReference type="GeneID" id="9677763"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85425"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85425"/>
    <dbReference type="eggNOG" id="ENOG502SE8I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021652_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZP00"/>
    <dbReference type="OMA" id="IDRHSHD"/>
    <dbReference type="OrthoDB" id="4332097at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF80">
        <property type="entry name" value="GRIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="315"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="751" mass="83899" checksum="FD2B20A304DAA513" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZP20</accession>
    <name>C7ZP20_FUSV7</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_101788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003039902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZP20"/>
    <dbReference type="GeneID" id="9677883"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101788"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101788"/>
    <dbReference type="eggNOG" id="ENOG502QQIF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_523845_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZP20"/>
    <dbReference type="OMA" id="NHYNAAS"/>
    <dbReference type="OrthoDB" id="5101229at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052258">
        <property type="entry name" value="Diverse_Func_Domain-Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37612">
        <property type="entry name" value="FIBROIN HEAVY CHAIN FIB-H LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37612:SF20">
        <property type="entry name" value="PER-HEXAMER REPEAT PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="520" mass="54600" checksum="D66F236C1F4086A5" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPW4</accession>
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        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="5" type="ORF">NECHADRAFT_102279</name>
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    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698974">
        <property type="protein sequence ID" value="EEU33951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039664.1">
        <property type="nucleotide sequence ID" value="XM_003039618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZPW4"/>
    <dbReference type="STRING" id="660122.C7ZPW4"/>
    <dbReference type="GeneID" id="9667185"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102279"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102279"/>
    <dbReference type="eggNOG" id="ENOG502S2DH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015493_3_0_1"/>
    <dbReference type="InParanoid" id="C7ZPW4"/>
    <dbReference type="OMA" id="NTIPERN"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU33951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="579" mass="64783" checksum="6DE284F79F9FF55E" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQ27</accession>
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    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_55911</name>
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    <organism evidence="8 9">
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698980">
        <property type="protein sequence ID" value="EEU33881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039594.1">
        <property type="nucleotide sequence ID" value="XM_003039548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQ27"/>
    <dbReference type="STRING" id="660122.C7ZQ27"/>
    <dbReference type="GeneID" id="9667115"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55911"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55911"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="InParanoid" id="C7ZQ27"/>
    <dbReference type="OMA" id="RIESFWF"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU33881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="46425" checksum="B05374116D3F8C32" modified="2009-10-13" version="1">MTISFFATRDNKVHRSLRSRVSSAYSMTSILGMEPQIQDVLDLNRRKLGELADGANYIAFDKMVNYFTFDVVGQLALGGKIGFLQQGKDVDGIIQSVSDGFYLMGNMGIFPLQMLWINNPVSKWFTKTFGGDRLNAFDVFIDWLDKRVEERMTNGLLPGQRRDLLQHFIEVKDAQGRQADKKEVMIEGVNILAAGADTTAIGILACLGYILTNPRSKTKLTQEIDNAYQELNIDDERREISFKEAEKLPYLSAVILESIRLHPSIQYQLPRNVPLEGAHIGEYFLPCGTTCGASARAVNCSREIFGSDAEEFRPERWIPRSPEDGERIKSEKSLLMTFGMGSRNCIGKHLATVELYKYIAQFFRYFDAELANKAKPWNTKTQWFAFQRGFLVAIKRREHLADVEGPVGNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZR90</accession>
    <name>C7ZR90_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_56607</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG699044">
        <property type="protein sequence ID" value="EEU33467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039180.1">
        <property type="nucleotide sequence ID" value="XM_003039134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZR90"/>
    <dbReference type="GeneID" id="9666702"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_56607"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_56607"/>
    <dbReference type="eggNOG" id="ENOG502SJFM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_3_0_1"/>
    <dbReference type="InParanoid" id="C7ZR90"/>
    <dbReference type="OMA" id="GIIIWHA"/>
    <dbReference type="OrthoDB" id="3923077at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF93">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="25"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU33467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="307" mass="34729" checksum="EE8482455CFC9344" modified="2009-10-13" version="1">MEGDAPWALGVMWTLTFITLVFVILRVYTRVVIVKTSGVDDFVYNFAFILLLLYTVFIHLSANYGFGQNMFEIEDVEDAVRAVLLEVIGQTFAIIGMAVAKCSLGLFLLRLLSVNMIWHRMAIWATMAGLMLTSISVVFVYWLQCTPPAYLWDHRIRGGFCHIKSVPAAFTLSIFCIIVDFFFAIFPWVLLWNLNMNKREKVIIAGSMSLGVFAGACGIKRTMELPNLTKKNYLKDTVRAIVWSAAEIVVTMVCIGIPVCRPLYKRVFQRLASNDAGESQLPRCSARLYRSSDQNMAVHRPDGRQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7YGR5</accession>
    <name>C7YGR5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_31316</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the wax synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054219.1">
        <property type="nucleotide sequence ID" value="XM_003054173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YGR5"/>
    <dbReference type="GeneID" id="9664300"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_31316"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_31316"/>
    <dbReference type="eggNOG" id="ENOG502SAIV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021051_1_1_1"/>
    <dbReference type="InParanoid" id="C7YGR5"/>
    <dbReference type="OMA" id="WHQTFRF"/>
    <dbReference type="OrthoDB" id="2796277at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF67">
        <property type="entry name" value="WAX SYNTHASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="9">
        <location>
            <begin position="342"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="130"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU48506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="532" mass="60915" checksum="7EE266F903D8E11E" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C7YGS6</accession>
    <name>C7YGS6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell division control protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_90042</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CDC6/cdc18 family.</text>
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        <property type="protein sequence ID" value="EEU47792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053505.1">
        <property type="nucleotide sequence ID" value="XM_003053459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YGS6"/>
    <dbReference type="FunCoup" id="C7YGS6">
        <property type="interactions" value="1088"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YGS6"/>
    <dbReference type="GeneID" id="9664306"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90042"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90042"/>
    <dbReference type="eggNOG" id="KOG2227">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012774_2_0_1"/>
    <dbReference type="InParanoid" id="C7YGS6"/>
    <dbReference type="OMA" id="LFEWSLH"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000094">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000547">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016314">
        <property type="entry name" value="Cdc6/18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="WHD_Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001767">
        <property type="entry name" value="Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="10">
        <location>
            <begin position="142"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc6/ORC1-like ATPase lid" evidence="11">
        <location>
            <begin position="315"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc6 C-terminal" evidence="9">
        <location>
            <begin position="456"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="545"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU47792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="603" mass="65288" checksum="9D2CA8C9FEE37CD7" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7YGW9</accession>
    <name>C7YGW9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_74768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054244.1">
        <property type="nucleotide sequence ID" value="XM_003054198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YGW9"/>
    <dbReference type="STRING" id="660122.C7YGW9"/>
    <dbReference type="GeneID" id="9664325"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74768"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74768"/>
    <dbReference type="eggNOG" id="ENOG502RSI8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073643_0_0_1"/>
    <dbReference type="InParanoid" id="C7YGW9"/>
    <dbReference type="OMA" id="WHTSYPA"/>
    <dbReference type="OrthoDB" id="5106519at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002986205" evidence="2">
        <location>
            <begin position="21"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU48531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="386" mass="39957" checksum="91C68E6F15E100B7" modified="2009-10-13" version="1">MRGYLPLLLALSASYTTITALPRPVIVAREPADEPKYSVVPLEPGDNDSGDDDSGSDDSESGSQGSGSGNGDDEDGDGIVTVIQTVVKTKKPVTHVVTKTGDASTVTATAPGKTVTKAVTKAVPTTISIINVDEQPQPQPITRTVTVAPEHSVSEPFIPEPSAPKPKPSEEPEPTSEPATTTTPKETTQSTSEATSETSSSAPAPEPTTEPEPQLPGPPAEPKESTQDSTTSTISTTSTTSSCVNSAPPAETRVQPPPFPNPPMFTSTITIPAPVPTTFATLTTSDTTTILQETTVPNGIPVEVNPSPETSVGGHESQVEPQPQPQPTVTVPFQAPIHLTTLVTSITTTSVAQVVAPEPTPPAQSQDDGSWHTTYPAGWNGTVLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHD2</accession>
    <name>C7YHD2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II holoenzyme cyclin-like subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_74930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053611.1">
        <property type="nucleotide sequence ID" value="XM_003053565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YHD2"/>
    <dbReference type="STRING" id="660122.C7YHD2"/>
    <dbReference type="GeneID" id="9674484"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74930"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74930"/>
    <dbReference type="eggNOG" id="KOG0834">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022000_7_1_1"/>
    <dbReference type="InParanoid" id="C7YHD2"/>
    <dbReference type="OMA" id="GHKHRDG"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20546">
        <property type="entry name" value="CYCLIN_SpCG1C_ScCTK2-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000072">
        <property type="entry name" value="Cyclin Pch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="114"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="323"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="406"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU47898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="437" mass="49714" checksum="A4B65CCC85DF98E3" modified="2009-10-13" version="1">MASIDRYRPPREGYQPPSLPANPRPERDSRSRSPRRRDAVPPAVPTPPRHSTRTSPPRPQRRRSQASPAQSGAQTPRAGPNQWSFTPNEVRSTPSIIEGIAPAEERMRRAKGVNFIYQAGVMLDLPQITLWVAGVFFHRFYMRCHMLPEKGGIHHYNIAATALFLANKVEENCRKTKDIIIAVAKVAQKNTKLIIDEQSKEYWRWRDSILTYEEVMLEQLTFDLMIDNPYQHLFKLLGKLEIVHNKHLRQAAWAFCNDACLTAIPLLIEARDVAISAIFFASVHTNQQIDDIDGEPWWKHLKGDEDRCSKAIEVMREFYTENPLRKQNPSLPSPAFHLENTRRRGDTLLSQPDTLSSTTGTPMEGDRASRSPGAASRVNGVSKDGREGGSQSKSDENDYAQRSPLKRREPDDGEPKNERAEKRARHSEDEEGELVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHQ8</accession>
    <name>C7YHQ8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Branched-chain amino acid aminotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_75055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054394.1">
        <property type="nucleotide sequence ID" value="XM_003054348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YHQ8"/>
    <dbReference type="STRING" id="660122.C7YHQ8"/>
    <dbReference type="GeneID" id="9664625"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75055"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75055"/>
    <dbReference type="eggNOG" id="KOG0975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020844_4_1_1"/>
    <dbReference type="InParanoid" id="C7YHQ8"/>
    <dbReference type="OMA" id="FASIWID"/>
    <dbReference type="OrthoDB" id="25921at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050571">
        <property type="entry name" value="Class-IV_PLP-Dep_Aminotrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42743">
        <property type="entry name" value="AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42743:SF11">
        <property type="entry name" value="AMINODEOXYCHORISMATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU48681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="36049" checksum="156E107B33A73BB5" modified="2009-10-13" version="1">MSTMQKILDTFQERQTQLEQSENPLSHGASLIEGQVSPLYEARIPILDQGFLHSDLTYDVPAAWDGRLFRFNDHLDRLETSCKKLPLKPPMSWDEVKQATIDLIAKSGIRDAYVQLIVTRGLRFVREPVSSDTPDSNFIYILVMLYVWIMPPQLQQIGGEAIVARTVRRIPPGAIDPTVKNLQWGDLIRGLLEAQDRGSQYPFLTDGDANITEGAGYNIVFVKDGALFTARKGVLEGITRRTVFDVAEVANISVHIDDVPTSLAFEADEIFMCTTAGGVMPITKLEGSAVGNGEIGPVTKLIWDGYWALHYDPKHTIEIKYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>C7YI30</accession>
    <name>C7YI30_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="5">PPIase</shortName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_73408</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054449.1">
        <property type="nucleotide sequence ID" value="XM_003054403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YI30"/>
    <dbReference type="STRING" id="660122.C7YI30"/>
    <dbReference type="GeneID" id="9664492"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_73408"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_73408"/>
    <dbReference type="eggNOG" id="KOG0884">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_16_3_1"/>
    <dbReference type="InParanoid" id="C7YI30"/>
    <dbReference type="OMA" id="VPFHRVM"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01928">
        <property type="entry name" value="Cyclophilin_PPIL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF2">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="6"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU48736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="167" mass="18085" checksum="EA5B7276D1F1C57D" modified="2009-10-13" version="1">MSVTLHTSLGDIKIEVYCESVPKTAENFLALCASGYYDQSPFHRLIPKFMTQTGAPATPNPPENPKGGRSIWGGAFEDEIRPALRHGARGVVSMANKGPGTNGSQFFITFDKAPHLDGLNTIFGRVIGDEGLATLAKMEAVEVDRKNRPKEPIRIEKVTIHANPIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7YI47</accession>
    <name>C7YI47_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_90291</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053744.1">
        <property type="nucleotide sequence ID" value="XM_003053698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YI47"/>
    <dbReference type="STRING" id="660122.C7YI47"/>
    <dbReference type="GeneID" id="9664501"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90291"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90291"/>
    <dbReference type="eggNOG" id="ENOG502RZE7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_5_3_1"/>
    <dbReference type="InParanoid" id="C7YI47"/>
    <dbReference type="OMA" id="WYFPSIG"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="3">
        <location>
            <begin position="53"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU48031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="267" mass="29267" checksum="0E485638BC7558AC" modified="2009-10-13" version="1">MAQEKDMWSSKVHFPTSLAYQNSASFVPKLATKVIGWLDLQKDDVLLDIGCGGSGSMHGVDSSPSMIEAARELCKDAKNSTFETIDATQLVSKPELQQGTFTKAFSNAAMHWILRPEDTRAQFFKGVYAALAPGGTFVFEMGGLGNVSEMRTAALGAVARRVGMKAALAADPWFFPDETWATKFLEDAGFVVERAEREWRPTPADKGGVEGWIRLMVSKLLDAVPGEVEREAAVQECIEVLREVCRNPGGGEMISYVRLRAMARKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7YI72</accession>
    <name>C7YI72_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_90306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054465.1">
        <property type="nucleotide sequence ID" value="XM_003054419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YI72"/>
    <dbReference type="STRING" id="660122.C7YI72"/>
    <dbReference type="GeneID" id="9664771"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90306"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90306"/>
    <dbReference type="eggNOG" id="ENOG502S0AR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030037_0_0_1"/>
    <dbReference type="InParanoid" id="C7YI72"/>
    <dbReference type="OMA" id="DRRFFPR"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039719">
        <property type="entry name" value="FBXO28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13252">
        <property type="entry name" value="F-BOX ONLY PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13252:SF9">
        <property type="entry name" value="F-BOX ONLY PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="8"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU48752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="596" mass="67342" checksum="2A6BBC5AFE68FA19" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJS9</accession>
    <name>C7YJS9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_75785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054040.1">
        <property type="nucleotide sequence ID" value="XM_003053994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJS9"/>
    <dbReference type="GeneID" id="9663972"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75785"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75785"/>
    <dbReference type="eggNOG" id="ENOG502SJKY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084522_0_0_1"/>
    <dbReference type="InParanoid" id="C7YJS9"/>
    <dbReference type="OMA" id="WIFRYGE"/>
    <dbReference type="OrthoDB" id="2446447at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02219">
        <property type="entry name" value="cupin_YjlB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047121">
        <property type="entry name" value="YjiB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448">
        <property type="entry name" value="BLR7373 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448:SF3">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-1" evidence="1">
        <location>
            <begin position="61"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU48327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="240" mass="26485" checksum="E56EE9D06E0B44DF" modified="2009-10-13" version="1">MVEVRQYHLIPTHLIPNSPRPLLHYKNVLLKRPGTAHCDPTEVWDMFTNNEWNVAWIFRYGSTQLSHFHSKAHECMAVLSGTATIRFGVADTSEDLEENTYGSAWEEGGVELQAEAGDVFIIPAGVAHKTYDVKPDEGFKLLTPGGGHGIEADDPRKVLSEIQLSGYTMMGAYNGGDWDFVQSGGDFEKSWAIPKPKNDPVLGQSSQGLCKTWRGNDRAPEGRKIAYKDGAAIQSPLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJW0</accession>
    <name>C7YJW0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AMP deaminase</fullName>
            <ecNumber evidence="4">3.5.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_74395</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="4"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054055.1">
        <property type="nucleotide sequence ID" value="XM_003054009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJW0"/>
    <dbReference type="FunCoup" id="C7YJW0">
        <property type="interactions" value="563"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YJW0"/>
    <dbReference type="GeneID" id="9663986"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74395"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74395"/>
    <dbReference type="eggNOG" id="KOG1096">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003782_0_0_1"/>
    <dbReference type="InParanoid" id="C7YJW0"/>
    <dbReference type="OMA" id="WLYFMFA"/>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01319">
        <property type="entry name" value="AMPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000214">
        <property type="entry name" value="AMP deaminase Amd1, putative (AFU_orthologue AFUA_8G02860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF0">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="94"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="241"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="871"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="943"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU48342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="965" mass="108102" checksum="4E28BFBBFE17113D" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7YK40</accession>
    <name>C7YK40_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_74474</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054092.1">
        <property type="nucleotide sequence ID" value="XM_003054046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YK40"/>
    <dbReference type="STRING" id="660122.C7YK40"/>
    <dbReference type="GeneID" id="9676723"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74474"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74474"/>
    <dbReference type="eggNOG" id="KOG0406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_7_2_1"/>
    <dbReference type="InParanoid" id="C7YK40"/>
    <dbReference type="OMA" id="WADHINR"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="316"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU48379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="507" mass="55646" checksum="4CE1F6EF9774553B" modified="2009-10-13" version="1">MATPSAPGPGSGPFAPAVAQYHRVALGIGLDGYVAPDLDEAYRLHAAQSGAAVTAPAPHHAPGQFGILAPTAVPVPVVETQQIQGVFGAQPPPPPPPQPVERSNGQLSSKIVVDPPDLEAWRDKLFNVDEMIVLTHEQFETYFPHVDNVYSHRSTQRYKRKPFVSHYWDCRMKGRPPGTPKSDDPNKKKRKRNARERDLCDVKIKITEYLPGAQLQLEPLDQGQSGPAILGGFAGVAGQQRFWTVQRVNGNGGNGKGDGVAGPHKHTLEKSDEIKKNSVQRYLAKQERETKKAQKPPSRKTTGAALITARKHAKENTLKLYGACFCPFSQRVWIALEAKGLAYQYCETDPFRRPAPTHLLEANPHGCVPAIRQGEWTCAESGVILEYLEDLGQGKPLLPTDAQSKATCRFWIDHTSIDSLVQAADEQGPFFLGLNLSLVDIHLAPFAIRLPRILTSLRGWSPPPPGSRWAKWLDSIEADESIRATTSDHELYADTVDLLVRRNGLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C7YKJ4</accession>
    <name>C7YKJ4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein arginine N-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PRMT2101</name>
        <name evidence="7" type="ORF">NECHADRAFT_123077</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053461.1">
        <property type="nucleotide sequence ID" value="XM_003053415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YKJ4"/>
    <dbReference type="FunCoup" id="C7YKJ4">
        <property type="interactions" value="927"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YKJ4"/>
    <dbReference type="GeneID" id="9676793"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_123077"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_123077"/>
    <dbReference type="eggNOG" id="KOG1499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017375_1_2_1"/>
    <dbReference type="InParanoid" id="C7YKJ4"/>
    <dbReference type="OMA" id="CTHTKVK"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060567">
        <property type="term" value="P:negative regulation of termination of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000001">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000050">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="5">
        <location>
            <begin position="64"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="6">
        <location>
            <begin position="166"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU47748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="345" mass="39627" checksum="8B4040F1D22E6840" modified="2009-10-13" version="1">MSGDKMEVELAEQKMNSMEHSEQHYFKSYDHHGIHEEMLKDEVRTRSYMNAIIQNKHIFKDKVVLDVGCGTAILSMFAAKAGAKHVIGVDMSTIIFKAREIVQANGLSDKITLLQGKMEEVQLPFPKVDIIISEWMGYFLLYESMLDTVLYARDTYLEKDGLIFPDKATIFFAGIEDGDYKDEKIEFWNDVYGFDYTPLKATALSEPLVDTVEVKAVVTDPAPVLTLDLYTCTTADLAFQIPFKLKANRDDFIHALVSWFDIDFTACHKPIRFSTGPHTKYTHWKQTVFYFEDVLTVQEGEEVTCNLDVRPNDKNRRDLDIQIAYDFVPEDGNRSSKGHMVYRMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7YKK8</accession>
    <name>C7YKK8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_90008</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins. Involved in mitophagy. Required for the switch to necrotrophic growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The mitochondrial prohibitin complex consists of two subunits (PHB1 and PHB2). The subunits assemble into a membrane-associated ring-shaped supercomplex of approximately 1 mDa. Interacts with ATG24/SNX4; the interaction is direct and plays a role in mitophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the prohibitin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053469.1">
        <property type="nucleotide sequence ID" value="XM_003053423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YKK8"/>
    <dbReference type="FunCoup" id="C7YKK8">
        <property type="interactions" value="905"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YKK8"/>
    <dbReference type="GeneID" id="9676801"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90008"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90008"/>
    <dbReference type="eggNOG" id="KOG3090">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047969_0_2_1"/>
    <dbReference type="InParanoid" id="C7YKK8"/>
    <dbReference type="OMA" id="NEGTHFQ"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035632">
        <property type="term" value="C:mitochondrial prohibitin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF1">
        <property type="entry name" value="PROHIBITIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="9">
        <location>
            <begin position="40"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU47756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="291" mass="31826" checksum="42781ECFFF8E7DE4" modified="2009-10-13" version="1">MQQARGGYGGGGGPKMPRAAGGAVFASLLIAGGAVVISNSLFNVDGGQRAIKYRRVSGVSKEIYAEGTHINIPWFETPIVYDVRAKPRNVASLTGTKDLQMVNITCRVLSRPQIDALPQIYRTLGADYDERVLPSIVNEVLKSVVAQFNASQLITQREMVARLVRENLSRRAARFNILLDDVSLTHLAFSPEFTAAVEAKQVAQQEAQRAAFIVDKARQEKQAMVVKAQGEARSAELIGEAIKKSKAYVELKKIENARQIAAQFQEAGSKNRLLLDSEGLGLNVFDDKEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7YKU2</accession>
    <name>C7YKU2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RTA1 like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_36730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052851.1">
        <property type="nucleotide sequence ID" value="XM_003052805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YKU2"/>
    <dbReference type="FunCoup" id="C7YKU2">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="GeneID" id="9670920"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_36730"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_36730"/>
    <dbReference type="eggNOG" id="ENOG502QURG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033465_3_1_1"/>
    <dbReference type="InParanoid" id="C7YKU2"/>
    <dbReference type="OMA" id="IRARIYY"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF35">
        <property type="entry name" value="RTA1 DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU47138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="32058" checksum="FB95BCC847EA3676" modified="2009-10-13" version="1">MARNYYKYEPSMAAAVIFIITFSASSLLHAFQILKTKTWFFIPFLVGSLFETIGFIGRAIGAEQSPHYTFPPYVMQHLLLLLGPTCYAASIYMILGRLIRLLDAERYSLIRSSWLTKFFLIGDLLSIALQGIGGGKVVNADTEDDRSTGENIIIGGLVVQIIFFSLFMIVTCLFHFRIRKSPTARAGSIKTRWELFLVILYITSILILIRSLFRLVEYAMGHDSELQSKEVYIYVLDAAPMLIASTLFNIFHPSKYLVAGKQLVDRSDSEMQLADYGTAYRPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7YKU8</accession>
    <name>C7YKU8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_103640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052855.1">
        <property type="nucleotide sequence ID" value="XM_003052809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YKU8"/>
    <dbReference type="STRING" id="660122.C7YKU8"/>
    <dbReference type="GeneID" id="9670922"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_103640"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_103640"/>
    <dbReference type="eggNOG" id="KOG3659">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016501_0_0_1"/>
    <dbReference type="InParanoid" id="C7YKU8"/>
    <dbReference type="OMA" id="WPKELIT"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11554">
        <property type="entry name" value="SLC6sbd_u2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF240">
        <property type="entry name" value="BLOATED TUBULES, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="2"/>
    </dbReference>
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            <end position="58"/>
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            <end position="382"/>
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    </feature>
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            <begin position="590"/>
            <end position="611"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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    </evidence>
    <sequence length="699" mass="76656" checksum="DFBB90625329D5ED" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
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        <name evidence="3" type="ORF">NECHADRAFT_77597</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
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                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
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                <person name="Lindquist E."/>
                <person name="Lamers C."/>
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                <person name="Geiser D.M."/>
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            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
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    </dbReference>
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    </feature>
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        <location>
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        </location>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
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                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
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                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
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                <person name="Gribskov M."/>
                <person name="Rep M."/>
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            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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    <dbReference type="HOGENOM" id="CLU_009969_0_0_1"/>
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    </dbReference>
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    </dbReference>
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        <location>
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        <location>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU46863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="703" mass="78389" checksum="95D8DBD6A63CAFED" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7YM46</accession>
    <name>C7YM46_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor IIE subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_103760</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TFIIE beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052594.1">
        <property type="nucleotide sequence ID" value="XM_003052548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YM46"/>
    <dbReference type="FunCoup" id="C7YM46">
        <property type="interactions" value="481"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YM46"/>
    <dbReference type="GeneID" id="9671126"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_103760"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_103760"/>
    <dbReference type="eggNOG" id="KOG3095">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056580_0_1_1"/>
    <dbReference type="InParanoid" id="C7YM46"/>
    <dbReference type="OMA" id="RTKKDNH"/>
    <dbReference type="OrthoDB" id="5323195at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001097">
        <property type="term" value="F:TFIIH-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07977">
        <property type="entry name" value="TFIIE_beta_winged_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054600">
        <property type="entry name" value="TFA2_E-tether"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040501">
        <property type="entry name" value="TFA2_Winged_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016656">
        <property type="entry name" value="TFIIE-bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003166">
        <property type="entry name" value="TFIIE_bsu_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22254">
        <property type="entry name" value="TFA2_E-tether"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18121">
        <property type="entry name" value="TFA2_Winged_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02186">
        <property type="entry name" value="TFIIE_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016398">
        <property type="entry name" value="TFIIE-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51351">
        <property type="entry name" value="TFIIE_BETA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIE beta" evidence="9">
        <location>
            <begin position="73"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="23"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="254"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR016398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU46881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="304" mass="33685" checksum="F53C58EE12411902" modified="2009-10-13" version="1">MSSYLDRQANAFKGTLSAAAAKISNPSSNKASSLAPPSLTPLSPSPSAASDPNTPSSKRKRDAAPEVPYSQPQLTGYGAEVKTQMTFAVEYLKKKGDTKSITEIIDHLSLRGYDEEHKRELAEGLRGHPRVDWKPDASLSEQTWKTGTYAHRPIIPNVKDATSLLGHLQAKTDASGVSVKDLKDGWPDCEDTLAKLEQQHRILVVRTKKDNLPRYVWPNDASLHHSVQPEFQAMWHRVPLPSIDDMHRKLVSVGQKPTSEDPHKAAQGQAAKPKQQKRRAGKRIGKATNVHMAHLMQDYSGMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C7YM49</accession>
    <name>C7YM49_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_77760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053104.1">
        <property type="nucleotide sequence ID" value="XM_003053058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YM49"/>
    <dbReference type="FunCoup" id="C7YM49">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YM49"/>
    <dbReference type="GeneID" id="9663945"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77760"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77760"/>
    <dbReference type="eggNOG" id="KOG1087">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036827_0_0_1"/>
    <dbReference type="InParanoid" id="C7YM49"/>
    <dbReference type="OMA" id="YGSVHRQ"/>
    <dbReference type="OrthoDB" id="10068368at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14232">
        <property type="entry name" value="GAT_LSB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16980">
        <property type="entry name" value="VHS_Lsb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044103">
        <property type="entry name" value="GAT_LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045007">
        <property type="entry name" value="LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789:SF1">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="5">
        <location>
            <begin position="17"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="6">
        <location>
            <begin position="227"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="139"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="371"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="171"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU47391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="48648" checksum="64224478F4333F35" modified="2009-10-13" version="1">MFQQKPYSAVTVTIENLTSESYEEEDLSGIPELVEVIKLQASGPGEAARAIRKKLKYGNVHRQIRALVILDGLIQNAGERFQRTFVDEPLLERLRVCGTSQLSDIAVRNKCRELFRGWTQYAGTPGLDKIARLHKELPKRKQAVTQERSKVLRETEENPFVDDEQEEAAKAARQAASSSHAPPTAAESFSHAHTKSSSGSGSFFGGSKDKKKEKDKAKGKRKPFNLEAEKETMKVVIADSSFAATNLMNALQSINREVERISENPAAVERFEACKLLRRKVLRYIHHVEEEQWLGGLLHANDELVHALMSFEQFDRSIDADSDSDDELAEQAHLYRMATIKGKEAMAKAANAQSPTGSQPPDLSELIISHSPTHAAPPRPAPRSKPAHSAPPPPPPQPPRPVAAPVVTNMDDDEDDDDPFGDKHELDTPGVERDQPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7YM82</accession>
    <name>C7YM82_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS7m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_36182</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052611.1">
        <property type="nucleotide sequence ID" value="XM_003052565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YM82"/>
    <dbReference type="STRING" id="660122.C7YM82"/>
    <dbReference type="GeneID" id="9671143"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_36182"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_36182"/>
    <dbReference type="eggNOG" id="KOG3291">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049057_0_0_1"/>
    <dbReference type="InParanoid" id="C7YM82"/>
    <dbReference type="OMA" id="QNPGHKF"/>
    <dbReference type="OrthoDB" id="9972728at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14868">
        <property type="entry name" value="uS7_Mitochondria_Fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000006">
        <property type="entry name" value="37S ribosomal protein S7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047988">
        <property type="entry name" value="Ribosomal_uS7m_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="9">
        <location>
            <begin position="178"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="16"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU46898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="350" mass="38159" checksum="6AAE7707D18E31FA" modified="2009-10-13" version="1">MSPRSRVWGACRALAVRSRPATPRPGPFANTLPQNRWYSNEGNDKPPKAIDNAPKPDESQSEPISQDASASEASTGKEDAETTGLTSSEEVLDDATLEQLFYGGRTVSSSIEGGLTPAQEHILYQEGTIPSAEKAEALVAAAENAHLTQADTEVENPGHKFGLPQRPWPQGFNLKKRYHPVLEQITRLLMRDGKLSVAQRNMATVMNNLRTAPPPIYSPKFPLLPGTPPAEHLPLNPILYITVAIDSVAPLLKIRNVAGAGGGGRALELPVPLGVRQRRRVAFNWILDVINKKPSKGSGRKQFPHRIAEEIIAVVEGRSSVWEKRKVVHKLGTAARANIGSNKLKTKKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C7YM98</accession>
    <name>C7YM98_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Mediator of RNA polymerase II transcription subunit 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Mediator complex subunit 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">NECHADRAFT_59159</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the SRB8-11 complex, which itself associates with the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Mediator complex subunit 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052622.1">
        <property type="nucleotide sequence ID" value="XM_003052576.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="C7YM98">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YM98"/>
    <dbReference type="GeneID" id="9664042"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_59159"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_59159"/>
    <dbReference type="eggNOG" id="ENOG502QQJC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002210_0_0_1"/>
    <dbReference type="InParanoid" id="C7YM98"/>
    <dbReference type="OMA" id="DRCTLFG"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009401">
        <property type="entry name" value="Med13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051139">
        <property type="entry name" value="Mediator_complx_sub13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021643">
        <property type="entry name" value="Mediator_Med13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041285">
        <property type="entry name" value="MID_MedPIWI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249:SF3">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06333">
        <property type="entry name" value="Med13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11597">
        <property type="entry name" value="Med13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18296">
        <property type="entry name" value="MID_MedPIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0010">Activator</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med13 N-terminal" evidence="14">
        <location>
            <begin position="53"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="MID" evidence="15">
        <location>
            <begin position="919"/>
            <end position="1091"/>
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        </source>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="EEU46909.1"/>
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            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1426" mass="155460" checksum="9F237298CCD3B9AC" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7YMN2</accession>
    <name>C7YMN2_FUSV7</name>
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        <recommendedName>
            <fullName evidence="11">Urea active transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_35431</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
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                <person name="Selker E.U."/>
                <person name="Salamov A."/>
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                <person name="Lindquist E."/>
                <person name="Lamers C."/>
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                <person name="Geiser D.M."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
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    <dbReference type="GeneID" id="9671224"/>
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    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
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            <end position="36"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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        </location>
    </feature>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU362091"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU46979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="673" mass="72296" checksum="488B92AC8D401DC9" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNL0</accession>
    <name>C7YNL0_FUSV7</name>
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            <fullName evidence="8">Pre-mRNA-splicing factor RSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pre-mRNA-splicing factor rse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_60384</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle control.</text>
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    <comment type="subunit">
        <text evidence="2">Associated with the spliceosome.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RSE1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EEU46588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="C7YNL0">
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    </dbReference>
    <dbReference type="STRING" id="660122.C7YNL0"/>
    <dbReference type="GeneID" id="9673754"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_60384"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_60384"/>
    <dbReference type="eggNOG" id="KOG1898">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003246_0_0_1"/>
    <dbReference type="InParanoid" id="C7YNL0"/>
    <dbReference type="OMA" id="PRATGHW"/>
    <dbReference type="OrthoDB" id="436637at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001143">
        <property type="entry name" value="Pre-mRNA-splicing factor rse-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000068">
        <property type="entry name" value="Pre-mRNA-splicing factor rse1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="12">
        <location>
            <begin position="20"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="13">
        <location>
            <begin position="464"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="11">
        <location>
            <begin position="856"/>
            <end position="1177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU46588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1212" mass="133814" checksum="ABA298A3708DF973" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7YP81</accession>
    <name>C7YP81_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription factor Rba50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_59788</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RPAP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051964.1">
        <property type="nucleotide sequence ID" value="XM_003051918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YP81"/>
    <dbReference type="FunCoup" id="C7YP81">
        <property type="interactions" value="152"/>
    </dbReference>
    <dbReference type="GeneID" id="9673117"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_59788"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_59788"/>
    <dbReference type="eggNOG" id="KOG1894">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031074_1_0_1"/>
    <dbReference type="InParanoid" id="C7YP81"/>
    <dbReference type="OMA" id="DQESPYY"/>
    <dbReference type="OrthoDB" id="348201at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039913">
        <property type="entry name" value="RPAP1/Rba50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013929">
        <property type="entry name" value="RPAP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013930">
        <property type="entry name" value="RPAP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483:SF18">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08620">
        <property type="entry name" value="RPAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08621">
        <property type="entry name" value="RPAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RPAP1 N-terminal" evidence="4">
        <location>
            <begin position="88"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1 C-terminal" evidence="3">
        <location>
            <begin position="295"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU46251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="46843" checksum="C7A08DF1706BB7A2" modified="2009-10-13" version="1">MDPTLLIGDIVERDSGDKKPVEFSDQPISSTGFPQHKRRWRSSAFKQQRAAEAAGQTPSARSQPQDRSEVNQSQNSTANMGFEDVEKKRIDHENRQKLASMSPAEIAQAQNDIMNGLNPALIQRLLQRATIDEPTGPSPFDPPPSETPQAPEPPPEIKIEDTSKTMASSATEDATQDAKSTKEPGSENKASPSPAVSTKKIADDYDEDQAPAQIPPDIFPITDLPKSVHFPAPPSLPDVDPSDPDFLATLHEKYFPNLPADPSKLAWMAPIPTQDSPADKDSSYYPHPEIAVSAFRFDFRGRFLSPRVSRSIPSSKGLHHHGEAPEAAGYTIAELARLARSAVPAQRCMAFQTLGRILYRLGNGEWGKTEDDPVAMGVWNSVKQGRVLQSLMEAAMGEGGHRGSRAYATEALWLFEKGGWKEKYKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQJ1</accession>
    <name>C7YQJ1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome maturation protein SDO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_104128</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052191.1">
        <property type="nucleotide sequence ID" value="XM_003052145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQJ1"/>
    <dbReference type="FunCoup" id="C7YQJ1">
        <property type="interactions" value="1032"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YQJ1"/>
    <dbReference type="GeneID" id="9672659"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_104128"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_104128"/>
    <dbReference type="eggNOG" id="KOG2917">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043216_1_0_1"/>
    <dbReference type="InParanoid" id="C7YQJ1"/>
    <dbReference type="OMA" id="AVNPQMD"/>
    <dbReference type="OrthoDB" id="10253092at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990932">
        <property type="term" value="F:5.8S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1250.10:FF:000001">
        <property type="entry name" value="SBDS, ribosome maturation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046928">
        <property type="entry name" value="SDO1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="SDO1/SBDS_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF1">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20268">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_domain_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="10">
        <location>
            <begin position="16"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS central" evidence="11">
        <location>
            <begin position="112"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS C-terminal" evidence="12">
        <location>
            <begin position="240"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="144"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU46478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="305" mass="33488" checksum="AC1E7E86C72B3770" modified="2009-10-13" version="1">MSRQINQPSNQIKLTNVSLVRLKKGKKRFELACYKNKVLEWRSGIETDLDNVLQIPNVFLNVSKGQTAPREDLDKAFGKGKATDDIILEILKKGEMQVGEKERAAQLERVHNEVISIVASKLVDPRTKRVYTSGMIEKALDMLSSQAHTSTPDKSATGTPATGDDGEAKPRPKEHHWTGVSTTKSAKSQALDAMKALISHQPIPVARARMRLRIACTTSVLKQAVKGPKGGNKDEDGEQKAVGTVKDKILSYVEQVESQDVMGSEWEVVGFVEPGAFKALSDFIGNETKGQGRVEVLDMAVTHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C7YR97</accession>
    <name>C7YR97_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="7">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25 26">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">NECHADRAFT_100492</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Chromosome</location>
            <location evidence="4">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="7"/>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051132.1">
        <property type="nucleotide sequence ID" value="XM_003051086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YR97"/>
    <dbReference type="FunCoup" id="C7YR97">
        <property type="interactions" value="907"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YR97"/>
    <dbReference type="GeneID" id="9665846"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100492"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100492"/>
    <dbReference type="eggNOG" id="KOG3087">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063953_0_0_1"/>
    <dbReference type="InParanoid" id="C7YR97"/>
    <dbReference type="OMA" id="HKLYMEY"/>
    <dbReference type="OrthoDB" id="3399at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000603">
        <property type="entry name" value="EKC/KEOPS complex subunit bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000845">
        <property type="entry name" value="Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022495">
        <property type="entry name" value="Bud32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03724">
        <property type="entry name" value="arch_bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="22" id="KW-0010">Activator</keyword>
    <keyword evidence="19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="20" id="KW-0779">Telomere</keyword>
    <keyword evidence="23" id="KW-0804">Transcription</keyword>
    <keyword evidence="21" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="29">
        <location>
            <begin position="31"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="EEU45419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="263" mass="29126" checksum="261550C83AA6A7EE" modified="2009-10-13" version="1">MTATATAPATDPAAQQAHQFPLPKILEYPASTPPTLITQGAEGRLYKSTYLLPDIPCALKYRPPKPWRHPTLDQRLTRHRILSEARILAKCRRDGVRVPAVYAVDEAAGWLMLEWIHGGPVRKSINERLGTRTEGIEDDTELKSLMRRIGTAIGNMHKVGIVHGDLTTSNMMLGPPTDPKNQSPLDGELVIIDLGLASGSVSDEDRAVDLYVLERAFGSTHPRAECIFSELLDAYGQAFKQAKIVLKKLEDVRMRGRKRSMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C7YS22</accession>
    <name>C7YS22_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Complex I intermediate-associated protein 84, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_40969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051277.1">
        <property type="nucleotide sequence ID" value="XM_003051231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YS22"/>
    <dbReference type="STRING" id="660122.C7YS22"/>
    <dbReference type="GeneID" id="9666051"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_40969"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_40969"/>
    <dbReference type="eggNOG" id="ENOG502S1M2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019319_0_0_1"/>
    <dbReference type="InParanoid" id="C7YS22"/>
    <dbReference type="OMA" id="CLVFGHM"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU45564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="794" mass="91254" checksum="3995905AFF4B8187" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSK0</accession>
    <name>C7YSK0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_122595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050972.1">
        <property type="nucleotide sequence ID" value="XM_003050926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSK0"/>
    <dbReference type="STRING" id="660122.C7YSK0"/>
    <dbReference type="GeneID" id="9668289"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_122595"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_122595"/>
    <dbReference type="eggNOG" id="ENOG502SCD5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013444_1_1_1"/>
    <dbReference type="InParanoid" id="C7YSK0"/>
    <dbReference type="OMA" id="DNSTYWH"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF68">
        <property type="entry name" value="GALACTOSE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="6"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU45259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="650" mass="69795" checksum="AA9B6BF8CADF53AA" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C7YT70</accession>
    <name>C7YT70_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_104387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051075.1">
        <property type="nucleotide sequence ID" value="XM_003051029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YT70"/>
    <dbReference type="GeneID" id="9666469"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_104387"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_104387"/>
    <dbReference type="eggNOG" id="ENOG502SBV2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062278_0_0_1"/>
    <dbReference type="InParanoid" id="C7YT70"/>
    <dbReference type="OMA" id="CHFHWDC"/>
    <dbReference type="OrthoDB" id="46529at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RING-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU45362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="263" mass="28140" checksum="5E460B29A0BA2DF9" modified="2009-10-13" version="1">MSLCKVCEESLVLRLDPDEDVDDEAGVSSAGPSTVSESVPDDLELPCGCHFHWQCLLDQSSDVAVSLKCPSCSTYLPANDAGPSATNQFLSAPSGAAILTRYVNEGGVQENLDILPSITEEAYLESHPEARPARALHVMSAEGDVGGIVELLRDASDEIEDLASFVRYQDPLADMKSGLHLAIEHNQEETLWLLLWLCSTIPDAAFPETARSVAQALGIGRLSVSAEGDIRGLRDSHGQTAADLAQQKQAQWASILQTGLLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7YTG6</accession>
    <name>C7YTG6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_84575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050329.1">
        <property type="nucleotide sequence ID" value="XM_003050283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YTG6"/>
    <dbReference type="GeneID" id="9665735"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84575"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84575"/>
    <dbReference type="eggNOG" id="ENOG502QQEE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_568535_0_0_1"/>
    <dbReference type="InParanoid" id="C7YTG6"/>
    <dbReference type="OMA" id="RSRWLEM"/>
    <dbReference type="OrthoDB" id="5154006at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU44616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="54984" checksum="EFA89ED6537B1604" modified="2009-10-13" version="1">MRRMRRGRRPPPLPPRIIFHVANAEAVRGYDPAAPGRSEGQGAPAAQPSYELNGAVVSPPLVQAPYELDGTPIDPSSQDGSTCVKGCNKKCPRGKCVKATRRTVSFKDDGSTQAENSESETQTNEDSSKTPSEAKKANNNESSNANSTEDESESQSDEPSTSEAEASSVNEDPDWSISQDCLLRGMKEGNSSLPWEKIATALGKKKPEVIARWNLIKNLPTKKDAEISSPDDITNSDDDTSGDADDESETDTDQESEEDEEEDEEEFEEEVGIEEQDSDDDQDEESEEDSYVDDDESDDDDEEEEEYEANTKGKSPSRNKWHTGVRNEKVAAENKKAKANAKVKAAQQDDHSSSGEDASSESSDVESSSSDSQVIINDSHERAKMRHLHKLLYPPEIHPQPDKDFCKKDCELLGSIDAKYKKSRWLEMQANFYNVTGRLIPLETIRAKCERAEAEEAEKEARRAKKAAEREKQDRQKVNEWIQDVPEKNESGGSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVN9</accession>
    <name>C7YVN9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_89598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049744.1">
        <property type="nucleotide sequence ID" value="XM_003049698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVN9"/>
    <dbReference type="STRING" id="660122.C7YVN9"/>
    <dbReference type="GeneID" id="9677113"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89598"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89598"/>
    <dbReference type="eggNOG" id="ENOG502SKXK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_3_1"/>
    <dbReference type="InParanoid" id="C7YVN9"/>
    <dbReference type="OMA" id="FEACCNA"/>
    <dbReference type="OrthoDB" id="2851338at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN LPX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="26"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU44031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="266" mass="28905" checksum="AB93D21C82386380" modified="2009-10-13" version="1">MASTLTLPDSRTLAYALDATPKDGPLVILSNPLSASFLLWDHVVKVLNENGFRTLRYDQPGHGGSSAPKNLDATFDSMADDVYHLLESLEIKKVDSWIGVSMGASTGIYFTTKYPNTVSKLAICDTIVSSPVNAGVEDLFVQRVAAAREAGNLETTIQGTMERWFGKEWLEKNPEEAQRVQALMSKTTVDGFETCCNALSSKTFDLRPLLGKVGKSIDDAVVIVGQNDANLPKVMAEMRTKIDDGFKAAGKEKLISLSSPTPSWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7YW69</accession>
    <name>C7YW69_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_56943</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049836.1">
        <property type="nucleotide sequence ID" value="XM_003049790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YW69"/>
    <dbReference type="FunCoup" id="C7YW69">
        <property type="interactions" value="467"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YW69"/>
    <dbReference type="GeneID" id="9677411"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_56943"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_56943"/>
    <dbReference type="eggNOG" id="KOG0257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_0_1"/>
    <dbReference type="InParanoid" id="C7YW69"/>
    <dbReference type="OMA" id="PRDFKLC"/>
    <dbReference type="OrthoDB" id="2414662at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016212">
        <property type="term" value="F:kynurenine-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034276">
        <property type="term" value="P:kynurenic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000024">
        <property type="entry name" value="Kynurenine--oxoglutarate transaminase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051326">
        <property type="entry name" value="Kynurenine-oxoglutarate_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807:SF20">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="35"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU44123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="425" mass="47600" checksum="FE92C7A0B49C6533" modified="2009-10-13" version="1">MSQTRKLHPAARVEGQRQDVWSIINEAAASSPNQPIVNLGQGFFGYNPPKFILDAAKEALDRVECNQYAPAKGRPRLRKAIADAYSPFWGRQLNPETEVVVTTGANEGMLSAFMGFIEPGDEVIVFEPFFDQYISNIQMAGGKIVYVPLHPPASGATSNSSAADWTVDFEELERAFTPRTKMIVINTPHNPVGKVFSKEEVQKIGDICVKNQVIILSDEVYDRLYYVPFNRIAKVSPEVEKITLTVGSAGKNFYATGWRVGWLIGPPELIQHVSAAHTRICFSTVAPLQEAAAVGFEKAATNGFWDETIKEMKGKIDRLKEVFEELHLPVTYPEGGYFLLVNMAKVKLPEDYPFPPHVASRPRDFKLAWFLIQEVGVAAIPPTEFYTEGNAHLAEDYIRFAVCKNDDVLEQAKERLRSLKKYIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C7YW71</accession>
    <name>C7YW71_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_74204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU43913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049626.1">
        <property type="nucleotide sequence ID" value="XM_003049580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YW71"/>
    <dbReference type="GeneID" id="9677413"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74204"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74204"/>
    <dbReference type="HOGENOM" id="CLU_498825_0_0_1"/>
    <dbReference type="InParanoid" id="C7YW71"/>
    <dbReference type="OrthoDB" id="4636359at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU43913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="546" mass="64119" checksum="E506AF34090D37F0" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWB6</accession>
    <name>C7YWB6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_74247</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU43932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049645.1">
        <property type="nucleotide sequence ID" value="XM_003049599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWB6"/>
    <dbReference type="GeneID" id="9677439"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74247"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74247"/>
    <dbReference type="eggNOG" id="ENOG502SXF6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_381740_0_0_1"/>
    <dbReference type="InParanoid" id="C7YWB6"/>
    <dbReference type="OMA" id="DSSENMI"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="90"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU43932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="775" mass="88283" checksum="03C23F1DED3E4194" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWR6</accession>
    <name>C7YWR6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_82758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049164.1">
        <property type="nucleotide sequence ID" value="XM_003049118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWR6"/>
    <dbReference type="STRING" id="660122.C7YWR6"/>
    <dbReference type="GeneID" id="9666552"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82758"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82758"/>
    <dbReference type="eggNOG" id="ENOG502RK3H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_963420_0_0_1"/>
    <dbReference type="InParanoid" id="C7YWR6"/>
    <dbReference type="OrthoDB" id="4424523at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU43451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="289" mass="33438" checksum="BC8C125E6B865732" modified="2009-10-13" version="1">MRSSHLCYPSPEEGIPEVREELGYRPWGLVTYRTAYGGHSDREFFKLRELIHNMVLKFQESDDKRFPMGQTHWPVVEDKKLLSNVTTQVVREQFSKWASDRGVPPSEDGWKYQVARFHYCLVADRRSLKSAETTFPIIGVLYKDWLPAWHPDRIGHEGKYVPDDWTPIEGNTEGDVGWFYCRIVSLGWYYDEMCVRGLWGKTPRLPCVSLYLGPDGFMVSVDLVCIGVVVHHESRKPRCGLSTLSNANSTHNYYPSLSCTMLKTRLEECTRYVGYSICHEPWWANEPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXH7</accession>
    <name>C7YXH7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_45379</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049305.1">
        <property type="nucleotide sequence ID" value="XM_003049259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXH7"/>
    <dbReference type="GeneID" id="9676947"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45379"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45379"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_11_5_1"/>
    <dbReference type="InParanoid" id="C7YXH7"/>
    <dbReference type="OMA" id="CLIYASQ"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF57">
        <property type="entry name" value="MALTOSE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="60"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU43592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="532" mass="59091" checksum="72A9A43402B2A182" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXR3</accession>
    <name>C7YXR3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_44891</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049342.1">
        <property type="nucleotide sequence ID" value="XM_003049296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXR3"/>
    <dbReference type="FunCoup" id="C7YXR3">
        <property type="interactions" value="160"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YXR3"/>
    <dbReference type="GeneID" id="9676996"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_44891"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_44891"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_1"/>
    <dbReference type="InParanoid" id="C7YXR3"/>
    <dbReference type="OMA" id="KVMQANA"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU43629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="276" mass="29076" checksum="37CA84F4ED28353A" modified="2009-10-13" version="1">MSSPPSFEAPWSLAEKTAIVTGGSRGIGQAIAIHLSRKGLTKLAITYATNVQAAEATLETCRGLGVKEAVAIQADALDPEFGPKLIAQVLERLNTTTIDILVNNAVLTDHSKVLPVKETTLQSFLDVMQGNVYAPVTLTTALLPHLPAYGGRVINISSVLAYQANADPTMTYGASKTALQSYTRSFAEAFSKESSATFNSVIVGLTLTDSIKASKDLMPPGYFDAQIRDTSAADRIGVPEDIAYIVGFLSSEEGRWVNGAAISANGGNKLVMPALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXY1</accession>
    <name>C7YXY1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Helix-turn-helix-domain containing protein type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_45394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049386.1">
        <property type="nucleotide sequence ID" value="XM_003049340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXY1"/>
    <dbReference type="GeneID" id="9666442"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45394"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45394"/>
    <dbReference type="eggNOG" id="ENOG502SPA9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090929_1_0_1"/>
    <dbReference type="InParanoid" id="C7YXY1"/>
    <dbReference type="OMA" id="GKRDYYV"/>
    <dbReference type="OrthoDB" id="3724345at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="entry name" value="dinb family like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018531">
        <property type="entry name" value="DUF1993"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922">
        <property type="entry name" value="BLL2446 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922:SF1">
        <property type="entry name" value="DUF1993 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09351">
        <property type="entry name" value="DUF1993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="DinB/YfiT-like putative metalloenzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU43673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="19292" checksum="6FF0FE6D5BC80901" modified="2009-10-13" version="1">MAFSLYDATIVDAKTILETLDGLLKKAEEQPNAESFLKARLYEDMNPLTFQIHAATRFAELVLARLTGREAVQYEDNLVSYADMHARIAEVLAALEKADKDTVNRYGEEVLPTALPSAGTMNITGKAFAKGAAMPNIYFHLNMTYAILRKEGVPLGKKDYAMGFAMDNILKPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYE5</accession>
    <name>C7YYE5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_46654</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
            <location evidence="1 6">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU42993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048706.1">
        <property type="nucleotide sequence ID" value="XM_003048660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYE5"/>
    <dbReference type="STRING" id="660122.C7YYE5"/>
    <dbReference type="GeneID" id="9665478"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_46654"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_46654"/>
    <dbReference type="eggNOG" id="KOG2065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005595_0_0_1"/>
    <dbReference type="InParanoid" id="C7YYE5"/>
    <dbReference type="OMA" id="NIAHRTY"/>
    <dbReference type="OrthoDB" id="78652at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF27">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="9">
        <location>
            <begin position="2"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="8">
        <location>
            <begin position="302"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="549"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="724"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="570"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU42993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="789" mass="88449" checksum="6B288BFA0EDE18FC" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0H4</accession>
    <name>C7Z0H4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_19478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047916.1">
        <property type="nucleotide sequence ID" value="XM_003047870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0H4"/>
    <dbReference type="STRING" id="660122.C7Z0H4"/>
    <dbReference type="GeneID" id="9671901"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_19478"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_19478"/>
    <dbReference type="eggNOG" id="ENOG502S71G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108574_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z0H4"/>
    <dbReference type="OMA" id="WMMVMAS"/>
    <dbReference type="OrthoDB" id="3930290at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="19240" checksum="8765B08236243EED" modified="2009-10-13" version="1" fragment="single">VRTYNWPPIQLNFWIFVILLASTSIIGVFSSFIQIQEQLLLPIPWYFPYFITVGSLTVIFIIGIFWLIAQRRLLPAIVMIGAFMFFVLWLVGLVIVGIQLFGPNGSIQSVCDVQVFGRNPTGQSERTMAWLQQRNICQCWQLVFAMSLTGTVFFIWVMIMAYQVFVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z178</accession>
    <name>C7Z178_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidate phosphatase APP1 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_39861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048027.1">
        <property type="nucleotide sequence ID" value="XM_003047981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z178"/>
    <dbReference type="GeneID" id="9671842"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_39861"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_39861"/>
    <dbReference type="eggNOG" id="ENOG502QSDV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024935_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z178"/>
    <dbReference type="OMA" id="FTPWMNM"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF2">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1 CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012632846" description="Phosphatidate phosphatase APP1 catalytic domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="2">
        <location>
            <begin position="276"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU42314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="515" mass="56710" checksum="20EB8F06DA10F418" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1M7</accession>
    <name>C7Z1M7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 1, mitochondrial</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 1 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 1 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSD1</name>
        <name evidence="14" type="ORF">NECHADRAFT_101889</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase 1 alpha chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
        <text evidence="12">Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase 1 beta chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="12"/>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU42025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047738.1">
        <property type="nucleotide sequence ID" value="XM_003047692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1M7"/>
    <dbReference type="FunCoup" id="C7Z1M7">
        <property type="interactions" value="494"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z1M7"/>
    <dbReference type="GeneID" id="9671702"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101889"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101889"/>
    <dbReference type="eggNOG" id="KOG2420">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029061_1_1_1"/>
    <dbReference type="InParanoid" id="C7Z1M7"/>
    <dbReference type="OMA" id="HSPASWV"/>
    <dbReference type="OrthoDB" id="4330at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03208">
        <property type="entry name" value="PS_decarb_PSD_B_type1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033661">
        <property type="entry name" value="PSD_type1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF6">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023577934" description="Phosphatidylserine decarboxylase 1 beta chain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023577935" description="Phosphatidylserine decarboxylase 1 alpha chain" evidence="12">
        <location>
            <begin position="495"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="12">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="12">
        <location>
            <begin position="107"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="495"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="12">
        <location>
            <position position="495"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="12">
        <location>
            <begin position="494"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="12">
        <location>
            <position position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU42025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="538" mass="60089" checksum="F37ED3FCC3E63379" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z2K9</accession>
    <name>C7Z2K9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_54322</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047396.1">
        <property type="nucleotide sequence ID" value="XM_003047350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z2K9"/>
    <dbReference type="STRING" id="660122.C7Z2K9"/>
    <dbReference type="GeneID" id="9676387"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_54322"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_54322"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002220_2_0_1"/>
    <dbReference type="InParanoid" id="C7Z2K9"/>
    <dbReference type="OMA" id="IWFFPEG"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="411"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU41683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="931" mass="102797" checksum="99399CC916027283" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z2Z0</accession>
    <name>C7Z2Z0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_53867</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047453.1">
        <property type="nucleotide sequence ID" value="XM_003047407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z2Z0"/>
    <dbReference type="GeneID" id="9675885"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_53867"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_53867"/>
    <dbReference type="eggNOG" id="ENOG502SI17">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_12_3_1"/>
    <dbReference type="InParanoid" id="C7Z2Z0"/>
    <dbReference type="OMA" id="YCPMALF"/>
    <dbReference type="OrthoDB" id="5378633at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF108">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="64"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU41740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="319" mass="34607" checksum="BA934E8F75A9C186" modified="2009-10-13" version="1">MSFPGAGPPPEGVVPNLEHPQDVLKSCNYVTQALTLVFVSAFVATRFYAKSKVLMVGYCITACSGYAATIFYAPMALTVKLALLSIIIRVFGSVHKKTMIGIYVFIGMLVAYYVSGLFIKIFICWPISAYWKGETDKCLNQSAIITADAIISFISDLAILLLPTPLTWSLHLSRRKRLRVIGILCAGGVATAFSIYRLAMILHEGKSPNQTIVFTKVILSGNAEAGIGLICACLPSISALLVRRQGYPYYGNQSHSTHNEFSRGEIMMTRSFHVETGKIAKGPQPDVYDLGHDEAGLVAAGQANPKSNLSSRRRSGSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z309</accession>
    <name>C7Z309_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-polygalacturonase</fullName>
            <ecNumber evidence="3">3.2.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Pectinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">NECHADRAFT_87786</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(1,4-alpha-D-galacturonosyl)n+m + H2O = (1,4-alpha-D-galacturonosyl)n + (1,4-alpha-D-galacturonosyl)m.</text>
            <dbReference type="EC" id="3.2.1.15"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.15" evidence="3"/>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047288.1">
        <property type="nucleotide sequence ID" value="XM_003047242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z309"/>
    <dbReference type="SMR" id="C7Z309"/>
    <dbReference type="FunCoup" id="C7Z309">
        <property type="interactions" value="146"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z309"/>
    <dbReference type="GeneID" id="9675897"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87786"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87786"/>
    <dbReference type="eggNOG" id="ENOG502QTAW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040116_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z309"/>
    <dbReference type="OMA" id="GYCHGGH"/>
    <dbReference type="OrthoDB" id="1546079at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000002">
        <property type="entry name" value="Endopolygalacturonase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050434">
        <property type="entry name" value="Glycosyl_hydrlase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884:SF1">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988893" description="endo-polygalacturonase" evidence="16">
        <location>
            <begin position="18"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEU41575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="376" mass="38728" checksum="4F450B0BDF500B1D" modified="2009-10-13" version="1">MTKINFLLAALAGSAIAAPSVPLIDAPEHFKRADSCTFSGSSGAAAAMKAQSSCTTLTLNNVAVPAGTTLDLSKLKDGAHVVFKGTTTWGYKEWTGPLLKISGKKITVDGAGATLNADGARWWDGKGGNGGKKKPKFFAAHSLTDSVFNDLYIKNTPVQAVSINTVNGLTINKMTIDDAEGDSKGGHNTDGFDIGESTGVTINGAKVYNQDDCVAINSGKDITFSGGLCSGGHGLSIGSVGGRSNNVVDTVKFLNSQVTKSTNGLRVKTMKNTSGQVKGVTYSDITLSKISKYGILIEQNYDGGDLHGDPTSGLPITGLTLKNISGSGAVDAKGTNIAIVCGKTGCSNWTWSNVKVNGGKDYGSCQNVPSVATCKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z331</accession>
    <name>C7Z331_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_54093</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047474.1">
        <property type="nucleotide sequence ID" value="XM_003047428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z331"/>
    <dbReference type="GeneID" id="9676218"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_54093"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_54093"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_7_1_1"/>
    <dbReference type="InParanoid" id="C7Z331"/>
    <dbReference type="OMA" id="YDAYTWE"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF152">
        <property type="entry name" value="OXIDASE (CODA), PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU41761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="542" mass="60002" checksum="E42CD3D3A3AD647B" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z494</accession>
    <name>C7Z494_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_83526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047155.1">
        <property type="nucleotide sequence ID" value="XM_003047109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z494"/>
    <dbReference type="STRING" id="660122.C7Z494"/>
    <dbReference type="GeneID" id="9675640"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83526"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83526"/>
    <dbReference type="eggNOG" id="ENOG502SC13">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060131_6_5_1"/>
    <dbReference type="InParanoid" id="C7Z494"/>
    <dbReference type="OMA" id="FEVMHIM"/>
    <dbReference type="OrthoDB" id="2744543at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU41442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="253" mass="28209" checksum="6B056E02E597F1DF" modified="2009-10-13" version="1">MSSITLRPATLADSDAISNIHYEALNKYHVFYGAFFQRHPRDIIRIGNRGAIQDPGRTVVVAEEGGEIVGFIIYQIANSNSNKSEDDTRDGPPLPISEPKEHLRELWDRFNERNAEMDKYKEEAIKGQKHYGTFPSIKPAECYLLTCSLEVLQLMVHPSHQRSGVGGRLLSSALAKADADSAPTLVTSSAEGHGLYLKHKFRSLGKTWPVDNAQWAGEAAKLDSNLRPDFVAACSDLYEEEDCMIRQPSFRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4I4</accession>
    <name>C7Z4I4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_33781</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046642.1">
        <property type="nucleotide sequence ID" value="XM_003046596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4I4"/>
    <dbReference type="STRING" id="660122.C7Z4I4"/>
    <dbReference type="GeneID" id="9678172"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_33781"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_33781"/>
    <dbReference type="eggNOG" id="KOG3867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_11_1_1"/>
    <dbReference type="InParanoid" id="C7Z4I4"/>
    <dbReference type="OMA" id="LMTGYQI"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16025">
        <property type="entry name" value="PAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000044">
        <property type="entry name" value="Arylsulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF33">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="6"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU40929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="605" mass="67452" checksum="808DD97B6263781B" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4X3</accession>
    <name>C7Z4X3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_76669</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU41000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046713.1">
        <property type="nucleotide sequence ID" value="XM_003046667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4X3"/>
    <dbReference type="STRING" id="660122.C7Z4X3"/>
    <dbReference type="GeneID" id="9678518"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76669"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76669"/>
    <dbReference type="eggNOG" id="KOG1632">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029385_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z4X3"/>
    <dbReference type="OMA" id="TIYKKTC"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037869">
        <property type="entry name" value="Spp1/CFP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174:SF1">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="58"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU41000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="383" mass="42858" checksum="A50D18C1DA59BA58" modified="2009-10-13" version="1">MPSHTAAKKKGTASAVKKSTKRTKNSGGPRAAKKSKSTPSSGSGQAPSEAASEESDNGPYCLCRGPDDHRWMIFCEHCEDWFHGECINMSKDIGEALIEKFICPNCTTDDLMTLYKKTCALSGCRRAARVAQEEQSVFCSNEHAQTWWERMVAKLPKTKGKGGINDQLVQEEFMALLSSGLSGVDEEGLWRLIKTPFSDEKPKEADKKEQDNEEDASKHLSEEEKEFLENAAATRFHLAEETVLCHKMLTLLDLAHSRRQAAISAGHFKEDICGYDQRLDTISARDSFAAFAKSPEGEAIFKASKLGDPLGEDDDVRGMCERKRCKIHSGWYKMLSLGIKYQIRELASQAGEVGEEEKVVRQAAKERWRRKRSEKNWVQVLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z573</accession>
    <name>C7Z573_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_33657</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU41049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046762.1">
        <property type="nucleotide sequence ID" value="XM_003046716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z573"/>
    <dbReference type="GeneID" id="9678567"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_33657"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_33657"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="InParanoid" id="C7Z573"/>
    <dbReference type="OMA" id="GKAMTKY"/>
    <dbReference type="OrthoDB" id="5325318at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF103">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU41049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="361" mass="38600" checksum="41E6C06E4559B7CC" modified="2009-10-13" version="1">MSFAARNLVRISRAAAPAFPRTATRCMSVTAMNRVHDTANKKSVVREKEVPVTVYGAGQGTGDKHTVNVTEGASQVPHDSPAPPAENDVVQPLTRKVFDQLPYTMRNMSVYGKTIIITGGARGLGNYMARACAEAGAKNLVIFDANQELGDEAAAELHDKTGLPVSFFKVDVRDGAAINAAVEEVVERYGAPDVLVNSAGIADSNIKAETYDPAMFRRLIDINLTGSFLMSQSVGRAMMAAGKPGSIVLVASMSGSIVNYPQEQSCYNASKAGVIQLGKSLAAEWAKYEIRVNCISPGYMDTALNRVPALDAQKKIWKSLTPQNRLGNVDELNGLCVFLASDASKFMTGSNCIIDGGYTCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z5B5</accession>
    <name>C7Z5B5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_99373</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046206.1">
        <property type="nucleotide sequence ID" value="XM_003046160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z5B5"/>
    <dbReference type="STRING" id="660122.C7Z5B5"/>
    <dbReference type="GeneID" id="9678588"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_99373"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_99373"/>
    <dbReference type="eggNOG" id="KOG2588">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041446_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z5B5"/>
    <dbReference type="OMA" id="MPNYSRT"/>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="394"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU40493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="510" mass="55942" checksum="23D573699B3E8586" modified="2009-10-13" version="1">MDPNLLSFFSVPNNQTLNPVDQNAESSTGAISQQQQQPQEPSPWRPLEGDMVDRTSGPQGGPVSSYDHQSSAPSDITFTQAPMPSPYTQHKTVLPTRGHPRTHPRKRDAHDRKRTKVDTESALESLDYWIQFDDDEAERTGSYEIDFSKRYDMMNNTTTTRPGFGSSSTTPGLGTGIYATAPPFKGNDYFDDNALDNALSDDEEGFDSMSLEEHLSKIETMPPPEVPPREGLYSTPLSWEKPEPGLRMEPNFGVGESPGGMSTAGYGQTMPGVGNQVLSNDEQRRLLAIAMNTGRTPASFMPPSGFGLGFGAGLGSGLPPEFNASIDSILGTPGEQSQKQTPTPADSTKAPSRNQDIKTEASSETGTALSSSRPQLHRSNTDTTDKGKDKMKSGDRTAHNDIERKYRTNLKDKIAELRNAVPALQSIPEDGIDEGEGNSQRAPKVSKGTVLTKATEYIQYLERRNKAIMKEHQELARRLQAFEQLLSASARQPFLMPNHSRTLFDPRGFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z5I0</accession>
    <name>C7Z5I0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynactin subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_99404</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046236.1">
        <property type="nucleotide sequence ID" value="XM_003046190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z5I0"/>
    <dbReference type="STRING" id="660122.C7Z5I0"/>
    <dbReference type="GeneID" id="9678623"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_99404"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_99404"/>
    <dbReference type="eggNOG" id="ENOG502S7GK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085418_2_1_1"/>
    <dbReference type="InParanoid" id="C7Z5I0"/>
    <dbReference type="OMA" id="ITMQAET"/>
    <dbReference type="OrthoDB" id="2355at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027777">
        <property type="entry name" value="DCTN6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072">
        <property type="entry name" value="DYNACTIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072:SF0">
        <property type="entry name" value="DYNACTIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU40523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="194" mass="20690" checksum="326B2DD7D25622F6" modified="2009-10-13" version="1">MSSKRHSILPAIDRSGPRPPVNFSSSLTISNNAMLQGTHSITMQSETVVHPRSKFESNLGSILIGRRCLIHERTHIGARPADIESAKPGGIALGDYVTIEAGSIIEAGGTEIGEGSTIQAGANIGCGSKIGKNCTVTQLSKLAPGTILPDNTVVFSNGTRRIDKRDISDHKKIALIKQLAILRKMIPSDPDKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z603</accession>
    <name>C7Z603_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_66036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046325.1">
        <property type="nucleotide sequence ID" value="XM_003046279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z603"/>
    <dbReference type="SMR" id="C7Z603"/>
    <dbReference type="STRING" id="660122.C7Z603"/>
    <dbReference type="GeneID" id="9668515"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_66036"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_66036"/>
    <dbReference type="eggNOG" id="ENOG502QQ71">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027506_3_0_1"/>
    <dbReference type="InParanoid" id="C7Z603"/>
    <dbReference type="OMA" id="IKLGTWC"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF68">
        <property type="entry name" value="GLYCOSIDASE CRH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002987898" description="GH16 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="21"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU40612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="276" mass="29163" checksum="B8BD26157FC02DDA" modified="2009-10-13" version="1">MFSKALSVAALALVAPALVSAQTSTTCNPLLATCPADPAFGKDTVHCDFTKGECAAFTNIGGTAIEYGEKGGVFTIPGLGVAPTIATGKYIFFGRVDVEVQAAPGVGIITSAVLQSDNLDEIDWEWIGGDNAQVQSNYFSKGDISTYDRGAFHPVVNPTGQFHVYSIEWTPSFVNWIIDGTVVRTLTYADAKGGSAFPQTPMQVKLGTWVAGRPDAEEGTVIWAGGMADFSQGPFSGYYKSISIVDYAGGDAPTTKSVKEYIYGDQSGSYQSIRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z614</accession>
    <name>C7Z614_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_75942</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046332.1">
        <property type="nucleotide sequence ID" value="XM_003046286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z614"/>
    <dbReference type="GeneID" id="9678437"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75942"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75942"/>
    <dbReference type="HOGENOM" id="CLU_1796978_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z614"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU40619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="144" mass="15266" checksum="59E5705F626993BF" modified="2009-10-13" version="1">MNGSPIRKLADSSLAILSGHKDPQAPSTNDQVGAPCQLKRALIGLWPPDVRSLYALMGRLGGKKNVCLTAHVGVTREAPQLLGGQTYSAVQIDDAADATTSLKYSALGDFFSGKVVDNLFFITFAARSLMGTEPKGRLGEAWCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6D4</accession>
    <name>C7Z6D4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_90728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046387.1">
        <property type="nucleotide sequence ID" value="XM_003046341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6D4"/>
    <dbReference type="FunCoup" id="C7Z6D4">
        <property type="interactions" value="959"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z6D4"/>
    <dbReference type="GeneID" id="9667947"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90728"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90728"/>
    <dbReference type="eggNOG" id="KOG1364">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021255_2_0_1"/>
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    <dbReference type="OMA" id="PAIFDCQ"/>
    <dbReference type="OrthoDB" id="270602at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.300.40">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="UBA-like_sf"/>
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        <property type="entry name" value="Ubiquitin-like_domsf"/>
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        <property type="entry name" value="UBX_dom"/>
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    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF6">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13899">
        <property type="entry name" value="Thioredoxin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
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    </dbReference>
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        <property type="entry name" value="UBA-like"/>
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    </dbReference>
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        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="454"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU40674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="536" mass="59666" checksum="164023F1C635ACFA" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z741</accession>
    <name>C7Z741_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translocation protein SEC62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_90911</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC62 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="9668229"/>
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    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90911"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040936_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z741"/>
    <dbReference type="OMA" id="WGWQETK"/>
    <dbReference type="OrthoDB" id="200187at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Sec62_asco"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00869">
        <property type="entry name" value="sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443:SF9">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03839">
        <property type="entry name" value="Sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="271"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="334"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="360"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010604"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00021257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEU40237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="392" mass="44136" checksum="3D523DF737F30239" modified="2009-10-13" version="1">MSSPPPQPGPGQIPMPMPGQRPTPEQIQAMQRQLAIDAEKAGMTVPEFIEHIKRQAQEQMRMRAQQQAQQGGHTHGPDCNHDHDHDHDHEHGHGHSHPQQGRPQPITPGPPNPKAIALAKFLRGQELKPRTVILNGERKDMFRVKRALRALQSPAYEKARKKNPLLPEITDRASLENTFKLLPLSMLALRVSKIEPQAGPNGKKPKRVKGQWTVKIEQQQEAKDDMYYIWLWEGSQIKRQIYAALALLAIFAVVLYPLWPLVLRQGVYYLSWGLLGLLGLFFVMAIFRVILFCITYFTTPPGLWLFPNLWEDVSFVDSFKPVWAWHETEKKKKKKKSAAAAPGTSPNPAFAAATGQVAPTSATTTGTDTQVKTGVHQRHYEAPKVEELADDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z828</accession>
    <name>C7Z828_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell wall protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_79643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045509.1">
        <property type="nucleotide sequence ID" value="XM_003045463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z828"/>
    <dbReference type="GeneID" id="9672410"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79643"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79643"/>
    <dbReference type="HOGENOM" id="CLU_880259_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z828"/>
    <dbReference type="OMA" id="ETRNKGT"/>
    <dbReference type="OrthoDB" id="5105471at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988569" description="Cell wall protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU39796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="31614" checksum="01C6C2E0425082D2" modified="2009-10-13" version="1">MKYTLLTAAALATIALAAPAPEKAVSVENTKDIANGGTLSLTLSLRPLLEDLLDSLNNIEVPTQSKAKVKRGHDQGAQLVKTLKGLLGNIQGHSNTIDKTLLRIRTGSITRPNGTKQCVDLLQTVTGLLDGVVGTLTGFPNIGGGEHNDEVLDILDPLVTGLSKTVSNVARTLAVRGGPVTGDTLKPVTTSLSNLLECLLDIDPSLDTGIQGLLNSVLGGVGTGTGTGTGTGTGTGVGTGTGIVGDLLNEVLTPVGGLLGSINLGVGVKLGGKGSVGGNSGGYDSDSSDDDDDEENSGGNGSSGSGNGSPIYNVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z914</accession>
    <name>C7Z914_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_104686</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>UDP-alpha-D-glucose + 2 NAD(+) + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045052.1">
        <property type="nucleotide sequence ID" value="XM_003045006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z914"/>
    <dbReference type="STRING" id="660122.C7Z914"/>
    <dbReference type="GeneID" id="9673063"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_104686"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_104686"/>
    <dbReference type="eggNOG" id="KOG2666">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023810_7_0_1"/>
    <dbReference type="InParanoid" id="C7Z914"/>
    <dbReference type="OMA" id="CFIAVGT"/>
    <dbReference type="OrthoDB" id="5059218at2759"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000001">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000032">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000193">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028356">
        <property type="entry name" value="UDPglc_DH_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374:SF3">
        <property type="entry name" value="UDP-GLUCOSE 6-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374">
        <property type="entry name" value="UDP-GLUCOSE DEHYDROGENASE/UDP-MANNAC DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="UDP-glucose/GDP-mannose dehydrogenase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="370"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="456"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="303"/>
            <end position="307"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU39339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="604" mass="65790" checksum="7441C9CB1DE60465" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9E4</accession>
    <name>C7Z9E4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_94455</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045205.1">
        <property type="nucleotide sequence ID" value="XM_003045159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9E4"/>
    <dbReference type="GeneID" id="9673366"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94455"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94455"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_6_2_1"/>
    <dbReference type="InParanoid" id="C7Z9E4"/>
    <dbReference type="OMA" id="MQMYSEH"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF210">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="13"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="91"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU39492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="591" mass="63327" checksum="0D5F780DB14AA8A8" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9R5</accession>
    <name>C7Z9R5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_94539</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044858.1">
        <property type="nucleotide sequence ID" value="XM_003044812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9R5"/>
    <dbReference type="GeneID" id="9672217"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94539"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94539"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_2_1"/>
    <dbReference type="InParanoid" id="C7Z9R5"/>
    <dbReference type="OMA" id="VPSQYFS"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF305">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="219"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU39145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="413" mass="43778" checksum="80054DC66F295850" modified="2009-10-13" version="1">MSTTTTAVELCEPIERTSRDEILKASRLADSTVPDGGYGWVIVGSGAVMLWWALGTTYAWGVMQRALIEDGLSTPAILSFIGSLDAALMSALAIINSRLMRAIGMRNTAVLGVAVMGGSEILSSFAVKNLGALFFTSGVLMGTGVSDCAMVQHQTWIWRCHAEFRCRCSHPEAQNFVGVSDSRSPYSLATGLPAAWAIRERAPTHTPRFIEWQLFKSFTFDLVFLASAVGTFPLFVPPFFLPLYTKSLGFSSTTGAGLVAGFNLASAFGRIACGLACDKLGSLNTLFLSLILAAITMLAIWPASTTLAPMIAFVLINGVSNGGFFSTMPTVVGNVFGSARVAMAMSMILTGWAGGYLMGAPIAGYLLEAYGGADAGLQAYRPAMFYAGSLALGSAGMVATVRLRKNRSPWARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9W6</accession>
    <name>C7Z9W6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 12">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NECHADRAFT_62182</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 12"/>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045286.1">
        <property type="nucleotide sequence ID" value="XM_003045240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9W6"/>
    <dbReference type="STRING" id="660122.C7Z9W6"/>
    <dbReference type="GeneID" id="9672067"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_62182"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_62182"/>
    <dbReference type="eggNOG" id="KOG1494">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047181_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z9W6"/>
    <dbReference type="OMA" id="FGCAVEL"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000001">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF16">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="13">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="148"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="8"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="118"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU39573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="331" mass="34466" checksum="252D953D9A5AE0EC" modified="2009-10-13" version="1">MVKAVVAGAAGGIGQPLSLLLKTSPHVDELALYDVVNTPGVATDLSHISSRAKTTGYLPANDGAKAAFKDADIIVIPAGIPRKPGMTRDDLFNINAGIVKGLIEVAAEVAPKAFILVISNPVNSTVPISAEVLKAKNVFNPQRLFGVTTLDIVRAETFVADIVGEANPQSLTIPVIGGHSGETIVPLFSKAKPAVSIPDDKYDALVNRVQFGGDEVVKAKDGAGSATLSMAYAGFRFAEKVLRAVKGETGLIEPSYVYLPGIPGGEAIAKQTGADFFSVPIELGPNGAEKAINPLEGITEKEQGLLAKCIEGLKGNITKGISFVHNPPQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAN5</accession>
    <name>C7ZAN5_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_82158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045422.1">
        <property type="nucleotide sequence ID" value="XM_003045376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAN5"/>
    <dbReference type="GeneID" id="9672377"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82158"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82158"/>
    <dbReference type="HOGENOM" id="CLU_1415535_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZAN5"/>
    <dbReference type="OrthoDB" id="4840035at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU39709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="192" mass="21866" checksum="1912381BBCB6E967" modified="2009-10-13" version="1">MFNSRIIVRRFTDQLTGADNLERSTKAAQAEIDEEHEMRERQRLELFFKSPENSVALQETIDKLTESAKPSMMQRIGISTKSTKTKTIEVLTDAVQGDFESLKASIDNLEKEWKAKHGRAAKTYGDIAETLSKAITRISEKVTTCSGFLEIIRTPRMRAKLADIYARMLGVAIIKSSAYALSRGYRDYKYRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCP0</accession>
    <name>C7ZCP0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amine oxidase</fullName>
            <ecNumber evidence="11">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NECHADRAFT_34648</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="11">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="10">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10 11">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="11"/>
    <dbReference type="EMBL" id="GG698918">
        <property type="protein sequence ID" value="EEU38294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044007.1">
        <property type="nucleotide sequence ID" value="XM_003043961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCP0"/>
    <dbReference type="STRING" id="660122.C7ZCP0"/>
    <dbReference type="GeneID" id="9670333"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_34648"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_34648"/>
    <dbReference type="eggNOG" id="KOG1186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011500_3_1_1"/>
    <dbReference type="InParanoid" id="C7ZCP0"/>
    <dbReference type="OMA" id="VPHYSQM"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000026">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF33">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="14">
        <location>
            <begin position="6"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="13">
        <location>
            <begin position="244"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="211"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="9">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="10">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU38294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="682" mass="77188" checksum="FCD6E0117ACA5595" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCS0</accession>
    <name>C7ZCS0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_84318</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698919">
        <property type="protein sequence ID" value="EEU37969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043682.1">
        <property type="nucleotide sequence ID" value="XM_003043636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCS0"/>
    <dbReference type="GeneID" id="9670167"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84318"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84318"/>
    <dbReference type="eggNOG" id="ENOG502S16A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020223_2_0_1"/>
    <dbReference type="InParanoid" id="C7ZCS0"/>
    <dbReference type="OMA" id="FMGPEST"/>
    <dbReference type="OrthoDB" id="2283488at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF30">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="46"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU37969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="613" mass="67259" checksum="0DB21991D64CB848" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDH1</accession>
    <name>C7ZDH1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_88197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043614.1">
        <property type="nucleotide sequence ID" value="XM_003043568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZDH1"/>
    <dbReference type="STRING" id="660122.C7ZDH1"/>
    <dbReference type="GeneID" id="9669444"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88197"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88197"/>
    <dbReference type="eggNOG" id="ENOG502SW0W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072627_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZDH1"/>
    <dbReference type="OMA" id="GRWTIAQ"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU37901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="36587" checksum="A785C1850E4A3A2F" modified="2009-10-13" version="1">MCFKATPATVYRKCGHKSEGVDNLPFKNPPEECLSIGPSQGLAYALNKDIVLKLPFQYEVTQDTEMSHCWDLSIGSFVAMEKEVAVYEALKAEPHPNFAGMLATNKTDYLFLERLEPLQDAWEGASREERHRWVLELLAAVSCLEKLDFVSGDLAVRNIGVDGAKRLKLFDFGSAISQSHWDYANEIPRDRFNLSTCLHFLLSGVDPLANLHSRAEAVKIRGMMEAGQWEISEDASILADMIQDGWTGKVESTTFSELLDEAARILNVKSEGPACDVAGSYYEELEGRCQEWLRSAQRDPLWKTPDEYVLSCREVGHEADLDTWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDS3</accession>
    <name>C7ZDS3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_88234</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043514.1">
        <property type="nucleotide sequence ID" value="XM_003043468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZDS3"/>
    <dbReference type="GeneID" id="9669733"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88234"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88234"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="InParanoid" id="C7ZDS3"/>
    <dbReference type="OMA" id="YAKATCI"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF26">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="22"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU37801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="521" mass="58528" checksum="F5734DA6B8B4961A" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEK0</accession>
    <name>C7ZEK0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_24662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698921">
        <property type="protein sequence ID" value="EEU37709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043422.1">
        <property type="nucleotide sequence ID" value="XM_003043376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEK0"/>
    <dbReference type="GeneID" id="9669307"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_24662"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_24662"/>
    <dbReference type="eggNOG" id="ENOG502QQ02">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034130_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZEK0"/>
    <dbReference type="OMA" id="MGTHGDL"/>
    <dbReference type="OrthoDB" id="284473at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051673">
        <property type="entry name" value="SSDNA_exonuclease_RecJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30255">
        <property type="entry name" value="SINGLE-STRANDED-DNA-SPECIFIC EXONUCLEASE RECJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30255:SF2">
        <property type="entry name" value="SINGLE-STRANDED-DNA-SPECIFIC EXONUCLEASE RECJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDH" evidence="1">
        <location>
            <begin position="42"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="386" mass="42933" checksum="DA8B0A40E5A2241A" modified="2009-10-13" version="1" fragment="single">PKNHFKRSLRDTNGEIIWPAPKNKIKAARKFIQECVSAKQRTLIVPDRDVDGLTSGAILERTLVLLGLDKDLISVHTIRKGGRLDDDVSRKAMADYKPAFIFVLDHGSQQSPPLIDAPHRAIVIDHHYAEENEHPQDALLVTADNSPPVATSSLLTYLICLDLHEEVKEICDWLCVLGTLGELGNMVKWEPPFPNMKPTIEMHKTGIIYQAISLIHAPRRTAACDVTIAWKALRAASSPKELTKDKNLVAARREIHEEFMRCNKSAAPRFSADGRVVVIYLSSEAQVHPLIASRWASYLYTDLVEVVLVANEGYSPGMVSFSCRVAKCAKGMFPPVDTIKFLRETADRAADPTLRDRLGESFARGHKVASGGKVPKAEFEELMEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEZ2</accession>
    <name>C7ZEZ2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline monooxygenase, chloroplastic</fullName>
            <ecNumber evidence="5">1.14.15.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NECHADRAFT_51619</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the first step of the osmoprotectant glycine betaine synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>choline + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = betaine aldehyde hydrate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:17769"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15870"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.14.15.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (monooxygenase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the choline monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.7" evidence="5"/>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043194.1">
        <property type="nucleotide sequence ID" value="XM_003043148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEZ2"/>
    <dbReference type="STRING" id="660122.C7ZEZ2"/>
    <dbReference type="GeneID" id="9665208"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51619"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51619"/>
    <dbReference type="eggNOG" id="ENOG502QQJW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026244_1_2_1"/>
    <dbReference type="InParanoid" id="C7ZEZ2"/>
    <dbReference type="OMA" id="SEVECNW"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="UniPathway" id="UPA00529">
        <property type="reaction ID" value="UER00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019133">
        <property type="term" value="F:choline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019285">
        <property type="term" value="P:glycine betaine biosynthetic process from choline"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00680">
        <property type="entry name" value="RHO_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03469">
        <property type="entry name" value="Rieske_RO_Alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015881">
        <property type="entry name" value="ARHD_Rieske_2Fe_2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF5">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00570">
        <property type="entry name" value="RING_HYDROXYL_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="14">
        <location>
            <begin position="77"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU37481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="438" mass="49978" checksum="CC817C1F3EF1942A" modified="2009-10-13" version="1">MTPTTSLSFDSSSLSAFAAFAAVLALVVKLLKKAVSAQKSAAGRNSFTTTTRALPASWYSSQEIYELERRAIFSKKWILVTHKLRFPESGSWIRYEEAGFQFFLVKNKDGKINGFHNICRHRAFPIVTKEQGQSSVLSCKYHGWSYGLNGQLAKAPGYLDMKGFDKTNNGLFPIHVYEDAKGFIWVNLDASKKPEAWSQDFHKIDQMSRHESFNFEDYHFDHTWEMSGDYNWKTLADNYNECYHCKTAHPDAGSVADLSAYKVDPKGGNIEHFANTTAKQEEEGLKIVSNYYFPNACMTVSPHFFYMMRCVPTSANHCSMEYEVYRHKNASDEDFTKIDEMFKRILSEDKWLCNNAQKNLNAGVFINGEMHPKMEQGPLYFQSQVRKFLNQHHRLEEAAKKEIRPAQQVLSGDKSVTEVDMGFCSGVACSKDKGALEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFA5</accession>
    <name>C7ZFA5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Short-chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_92268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698923">
        <property type="protein sequence ID" value="EEU37186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042899.1">
        <property type="nucleotide sequence ID" value="XM_003042853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFA5"/>
    <dbReference type="STRING" id="660122.C7ZFA5"/>
    <dbReference type="GeneID" id="9665109"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_92268"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_92268"/>
    <dbReference type="eggNOG" id="KOG1014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103010_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZFA5"/>
    <dbReference type="OMA" id="EPREWYQ"/>
    <dbReference type="OrthoDB" id="5336600at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF4">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU37186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="25194" checksum="7C7C0A56D3586746" modified="2009-10-13" version="1">MSAPNHPVILIFGAGANTGYGVADSFSRKGYKVAIVSRGALTPVFEERDFLHIRGDLADAASVEAAYQRTVDELGTPSVVVHNGESAYASTMAPDNADPIQLPVADLAADLAINTTSVLQLLQLATSSFAKLPDSTSRTFIYTGNKANLQPFPPFLSLGVGKAASSHMISFAAKTYSPQGYKFYYADQRNEDGSPVLAAIDGKAHGEFYTELAESKTQGPWLASFVKGKGYVKFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZGM0</accession>
    <name>C7ZGM0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Beta-xylosidase C-terminal Concanavalin A-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_13630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698925">
        <property type="protein sequence ID" value="EEU36825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042538.1">
        <property type="nucleotide sequence ID" value="XM_003042492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZGM0"/>
    <dbReference type="GeneID" id="9670129"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_13630"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_13630"/>
    <dbReference type="eggNOG" id="ENOG502SIVT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016508_3_0_1"/>
    <dbReference type="InParanoid" id="C7ZGM0"/>
    <dbReference type="OMA" id="PGHWNTL"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18833">
        <property type="entry name" value="GH43_PcXyl-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF17">
        <property type="entry name" value="BETA-XYLOSIDASE C-TERMINAL CONCANAVALIN A-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="6">
        <location>
            <begin position="345"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="4">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU36825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="565" mass="62547" checksum="A2C9727E74C654C2" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZGW2</accession>
    <name>C7ZGW2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_105602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698927">
        <property type="protein sequence ID" value="EEU36678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042391.1">
        <property type="nucleotide sequence ID" value="XM_003042345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZGW2"/>
    <dbReference type="ESTHER" id="nech7-c7zgw2">
        <property type="family name" value="Fungal-Bact_LIP"/>
    </dbReference>
    <dbReference type="GeneID" id="9669787"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_105602"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_105602"/>
    <dbReference type="eggNOG" id="ENOG502QRF9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029538_5_1_1"/>
    <dbReference type="InParanoid" id="C7ZGW2"/>
    <dbReference type="OMA" id="EGCTIQN"/>
    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF5">
        <property type="entry name" value="LIP-DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002987095" evidence="2">
        <location>
            <begin position="21"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU36678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="424" mass="45189" checksum="4F81DF94601714E1" modified="2009-10-13" version="1">MALLHRVLALVSLWLGVVSAAQASHLHKRSSSAGPLPPSQDPWYTAPDGFENAEPGAVLRLRPAPGNLTKITGNSSAVYNILYRTTDSQYKPTWAVTTLFVPELGPNSTAARNFDQAALLSYQVPYDSADVDASPSYTLYDADTSVPFGIVLGLGLFISVPDYEGPLASFTAGVISGHATIDSVRAVLSLGLGLNTTSPRVALWGYSGGALASEWASELAVQYAPELSETIVGAALGGLTPNVTSVLESITGQDGAGLAPSAILGLTSQYPEVQKYLISKLKTEGPYNKTGFLAALDFTSPEAGVAYAGVDIGDFFKDGLDTFRDPKLQRIINRDGIMGYHGVPQWPIFAYKAINDEISKVGANILYQRNSVGTHSEEFAYGLSAVFEWLGAVLTGTYAENVTRNDTSSPLKRRDVPNGVFNLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZGY0</accession>
    <name>C7ZGY0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_86480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698927">
        <property type="protein sequence ID" value="EEU36600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042313.1">
        <property type="nucleotide sequence ID" value="XM_003042267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZGY0"/>
    <dbReference type="GeneID" id="9669640"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86480"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86480"/>
    <dbReference type="eggNOG" id="ENOG502SI33">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004083_5_3_1"/>
    <dbReference type="InParanoid" id="C7ZGY0"/>
    <dbReference type="OMA" id="CVLMKFE"/>
    <dbReference type="OrthoDB" id="2269373at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF85">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU36600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="631" mass="72032" checksum="3E2E3EA6DF6F64DE" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZGY2</accession>
    <name>C7ZGY2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_86482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698927">
        <property type="protein sequence ID" value="EEU36687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042400.1">
        <property type="nucleotide sequence ID" value="XM_003042354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZGY2"/>
    <dbReference type="STRING" id="660122.C7ZGY2"/>
    <dbReference type="GeneID" id="9669481"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86482"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86482"/>
    <dbReference type="eggNOG" id="ENOG502RZ77">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002639_6_0_1"/>
    <dbReference type="InParanoid" id="C7ZGY2"/>
    <dbReference type="OMA" id="VQDYTRR"/>
    <dbReference type="OrthoDB" id="5125733at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="221"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU36687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="670" mass="75571" checksum="54A98ED31E541972" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="3">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_51778</name>
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    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
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            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EEU36712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003042379.1"/>
    </dbReference>
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    <dbReference type="STRING" id="660122.C7ZH93"/>
    <dbReference type="GeneID" id="9669665"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51778"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51778"/>
    <dbReference type="eggNOG" id="KOG0272">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_6_16_1"/>
    <dbReference type="InParanoid" id="C7ZH93"/>
    <dbReference type="OMA" id="IWQVKTG"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
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        <property type="match status" value="5"/>
    </dbReference>
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        <property type="match status" value="7"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
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        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="175"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="736"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="778"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="820"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="906"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="948"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU36712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1103" mass="123654" checksum="9D1CD5E59E051C20" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHH6</accession>
    <name>C7ZHH6_FUSV7</name>
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        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_81246</name>
    </gene>
    <organism evidence="3 4">
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        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698928">
        <property type="protein sequence ID" value="EEU36469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="GeneID" id="9669364"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_81246"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_81246"/>
    <dbReference type="eggNOG" id="ENOG502SMAU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054243_2_0_1"/>
    <dbReference type="InParanoid" id="C7ZHH6"/>
    <dbReference type="OMA" id="KYAWADD"/>
    <dbReference type="OrthoDB" id="5275938at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
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        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="36"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU36469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="250" mass="28153" checksum="C7E90EBDA60824BE" modified="2009-10-13" version="1">MPPKKLVPAKKRKRPEPETASKEDETPFMREIIPDGDVILIVGPEKSKIQVSSHLLRTTSPVFNVMLGPNFKEGAALRENEGPTEIVLPEDNAKALWNVYSTLYGANPHVNKLKPDEIYDVAVLAQKYDLIDRLELACESWFAHTGAITYGSTKKDWKMLLAAYWLRSELGFKNTSIMLIEADQEPLYRFGMGTSDQVLGLRLCLAIYELRVAGFEDFGLCLSCFESPETEEFSEGNPKCTSKYRESVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHL3</accession>
    <name>C7ZHL3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Saponin hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_94102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698928">
        <property type="protein sequence ID" value="EEU36432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042145.1">
        <property type="nucleotide sequence ID" value="XM_003042099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHL3"/>
    <dbReference type="GeneID" id="9669332"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94102"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94102"/>
    <dbReference type="eggNOG" id="ENOG502SH4T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_446240_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZHL3"/>
    <dbReference type="OMA" id="FSRLQFN"/>
    <dbReference type="OrthoDB" id="10265322at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU36432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="661" mass="71733" checksum="9DB285A33178789B" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHW6</accession>
    <name>C7ZHW6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_52696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698929">
        <property type="protein sequence ID" value="EEU36353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042066.1">
        <property type="nucleotide sequence ID" value="XM_003042020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHW6"/>
    <dbReference type="GeneID" id="9674402"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_52696"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_52696"/>
    <dbReference type="eggNOG" id="ENOG502SMA9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002341_7_2_1"/>
    <dbReference type="InParanoid" id="C7ZHW6"/>
    <dbReference type="OMA" id="GQGIFHI"/>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="103"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU36353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="358" mass="41440" checksum="46846CCFA59E6709" modified="2009-10-13" version="1" fragment="single">MVQQDSSKLEQLQTHMKQLQKGVEAQVIGEEALKQLRLVLGIHDKALSAIYQDRILRSLQFEKIHLRDNGVQDPYENTFKWILEDDEGIMSHDFQEDRKRHSRDMFLTWLSSGSGIFHISGKLGSGKSTLMRYLSTHSLTRIEIGKWAGDRTLVLASFFFWKPGSELQKSLQGLFRSLLYDVLTACPDLIRDTLPEYWRLAEQAPWQIQTRFNIPSCTVNSALQNVFSDVRLYRGHRFCFFIDGLDEYEGTDGQDPTHLVALLKSWVKDSHGCLKLCVSSREHNVFMNALSKDQRLRLHELTLFDMQEYVAGHLKDMPSDTLSEHLRNDLITSIPEKADGIFLWTILVVRTIRRKIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZI41</accession>
    <name>C7ZI41_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_102056</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698929">
        <property type="protein sequence ID" value="EEU36309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042022.1">
        <property type="nucleotide sequence ID" value="XM_003041976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZI41"/>
    <dbReference type="FunCoup" id="C7ZI41">
        <property type="interactions" value="1397"/>
    </dbReference>
    <dbReference type="GeneID" id="9674359"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102056"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102056"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="InParanoid" id="C7ZI41"/>
    <dbReference type="OMA" id="QTTVSWM"/>
    <dbReference type="OrthoDB" id="5141738at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000044">
        <property type="entry name" value="Hexose transporter Hxt3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF92">
        <property type="entry name" value="LOW AFFINITY GLUCOSE TRANSPORTER MSTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="37"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="505"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="505"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU36309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="527" mass="58117" checksum="F45B68788FB60DB0" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZID7</accession>
    <name>C7ZID7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_52921</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698930">
        <property type="protein sequence ID" value="EEU36242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041955.1">
        <property type="nucleotide sequence ID" value="XM_003041909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZID7"/>
    <dbReference type="STRING" id="660122.C7ZID7"/>
    <dbReference type="GeneID" id="9674277"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_52921"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_52921"/>
    <dbReference type="eggNOG" id="ENOG502SKXY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010813_1_1_1"/>
    <dbReference type="InParanoid" id="C7ZID7"/>
    <dbReference type="OMA" id="FWLCYIS"/>
    <dbReference type="OrthoDB" id="4116913at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="310"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU36242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="645" mass="73165" checksum="5BD70285FB4BDF38" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJT3</accession>
    <name>C7ZJT3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_97887</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698936">
        <property type="protein sequence ID" value="EEU35683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041396.1">
        <property type="nucleotide sequence ID" value="XM_003041350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJT3"/>
    <dbReference type="STRING" id="660122.C7ZJT3"/>
    <dbReference type="GeneID" id="9676273"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_97887"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_97887"/>
    <dbReference type="eggNOG" id="ENOG502S0JD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_8_4_1"/>
    <dbReference type="InParanoid" id="C7ZJT3"/>
    <dbReference type="OMA" id="WEQMGSK"/>
    <dbReference type="OrthoDB" id="9997102at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU35683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="283" mass="30056" checksum="71FD56672BDADEA3" modified="2009-10-13" version="1">MSLPHKTLLVTGATGKQGGAVISSILASTQAASFNIIGVTRNSASDGARRLAALPGVSVVEGELSDVSAIFAQVGPVWGVFSVMVNSNDEERYGKAMVDAAVSHGVQHFVYASGDRGGPVKSNFDPTNVKNFAAKYNIEKHLIAQATLSPQQMTYTILRPVTFFENLTADIHGRGFVRMWEQLGTKKLQFVATSDIGWFAARSFLDPSAHAGAAITIAGDELTQPEADAIFKQVTGQSMPIGPCVIANTVKMVLKDTAAATCTRVLRTSGIGLRRTRESGRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZK07</accession>
    <name>C7ZK07_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_88001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698936">
        <property type="protein sequence ID" value="EEU35727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041440.1">
        <property type="nucleotide sequence ID" value="XM_003041394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZK07"/>
    <dbReference type="STRING" id="660122.C7ZK07"/>
    <dbReference type="GeneID" id="9676270"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88001"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88001"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_12_0_1"/>
    <dbReference type="InParanoid" id="C7ZK07"/>
    <dbReference type="OMA" id="FMIAKGL"/>
    <dbReference type="OrthoDB" id="2898618at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU35727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="291" mass="30894" checksum="FB50CE16BBE8F363" modified="2009-10-13" version="1">MASLNIAQLFSVKGHVAIVTGATSGLGFMISKGLVVNGARLYVVALPSEPIQEKVAELNELGQSSGGVAFGQRNIQELADYINHRESHLDILVSNAGIRRDPPVQCDVLTAPLSELQASMWSSVDTDWADTFSVNTTAHYFLSVALMPLLSAASQLYLGNNQLGRSQGRGVIIMTSSCASMHNATNVDLTSYATSKAATDHLVRLLAAKFSRFYVRVTGINPGFVPSNMNPVGQEGNMFSALFDQVPAKRAGNEEDIAGAVLYLASRAGSYVDGVSLCVDGGRILLANGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKF2</accession>
    <name>C7ZKF2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_98217</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698938">
        <property type="protein sequence ID" value="EEU35549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041262.1">
        <property type="nucleotide sequence ID" value="XM_003041216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKF2"/>
    <dbReference type="FunCoup" id="C7ZKF2">
        <property type="interactions" value="247"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZKF2"/>
    <dbReference type="GeneID" id="9675832"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_98217"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98217"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_16_1_1"/>
    <dbReference type="InParanoid" id="C7ZKF2"/>
    <dbReference type="OMA" id="FAEYCIP"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="5"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU35549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="301" mass="32321" checksum="F6BE054DC5C81B5E" modified="2009-10-13" version="1">MSNHAIVIQLSWRHGYITVKVKAVALNPTDILHIDYFASPGARQVGSLVTKRLKKGDRVAGFAHGSNALHHEDGTFAEYITAKGDLLFLVPNNVTFEEAVTLGISITTVRQALYQSLGLPTPAAPAREKFSVLIYGGSTATGALAIRFAKLSGLEVITTVSPKHFDYVKVLSADVAFDYSSETVVRDIKCATGGRLKYAFDCISKEPRAKISVGAFGDDGGIYTTLLPIPAELVSSINDKVTPKFTLAYSSIGEAFEVGQSIPANPDDFTFAKTFWVLTEKLLGEGKIKFMNPGLIMAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKM6</accession>
    <name>C7ZKM6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-xylosidase C-terminal Concanavalin A-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_86206</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698940">
        <property type="protein sequence ID" value="EEU35465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041178.1">
        <property type="nucleotide sequence ID" value="XM_003041132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKM6"/>
    <dbReference type="GeneID" id="9675708"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86206"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86206"/>
    <dbReference type="eggNOG" id="ENOG502SHCU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016508_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZKM6"/>
    <dbReference type="OMA" id="DMTGHDF"/>
    <dbReference type="OrthoDB" id="5060751at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF12">
        <property type="entry name" value="BETA-XYLOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU35465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="41389" checksum="46B69B4B2B8EB880" modified="2009-10-13" version="1">MGESIQRPSTLQGKNVSASHKSSQYAAYTVYLRLYPSNLLLLAHSDTSLFWDDDDRVYLIGSAATAPETKIRPFEIDLKTGKKLSEEKLLWEGITKVFPEGPHMYKKDGWYYLLIAEGGCFADHHTIMARSKSIWGPVEVKLENLVMRKTDPNEYIQYTGHGDLFQDPSGQWYFICLGVRKTKEGRFIMGRETVITTTQWPEGEFPTIDFAKMDVPVKGGKQPAPAWLLKSSGSSLTLDVELMHIRNPVEENYKYDGSKTTLIDSNAPLNQSSEPVSFVGKRQRLLDGTASVILNVLDTSALEDTLEAGLCYYKDELRFTRVLLDGVKEELAQIDSPDMTEHVFVGPVIGAFGTAAKESRLEFVDLVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKP4</accession>
    <name>C7ZKP4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_51276</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698940">
        <property type="protein sequence ID" value="EEU35438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041151.1">
        <property type="nucleotide sequence ID" value="XM_003041105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKP4"/>
    <dbReference type="STRING" id="660122.C7ZKP4"/>
    <dbReference type="GeneID" id="9675723"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51276"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51276"/>
    <dbReference type="eggNOG" id="ENOG502S0XP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZKP4"/>
    <dbReference type="OMA" id="ICQVGFM"/>
    <dbReference type="OrthoDB" id="446809at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000132">
        <property type="entry name" value="NAD-binding Rossmann fold oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000017">
        <property type="entry name" value="Oxidoreductase family NAD-binding Rossmann fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF11">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09900)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="7"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="3">
        <location>
            <begin position="137"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU35438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="39543" checksum="B7E7A5BE6D684FA8" modified="2009-10-13" version="1">MAPQKLKIAAAGLGRMGKRHAINFLNRTPRAELVAAFTPDPEEMAWAKVNLEPHGVTLYDDYQKMIEQPGLQAVVIGTATSVHAEEAIQAMQKDLHVLCEKPLSTSIEICRDVVNEAKKRPHLKVMCGFSRRFDQSYRDAHEKMEQGAIGRPTIIRSQTCDKHDPSGFFVAYAAWSGGVFVDMSVHDIDLTLWFFGDDVIPKSVSAHGVRAVQPDLGKYNDYDNAVGIVEFWGGKIAYYYCSRMMAHGQEDTTEIIGTEGKLTVNGNPQSNLVNYYHSGGITREVPAHYYGRFEMAFVQESNEFAEACLDNKTLPLKLTNAVRAVEIGAALQEALVSGKQIRFDEVGRRIEETKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKQ2</accession>
    <name>C7ZKQ2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7703 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_51153</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698940">
        <property type="protein sequence ID" value="EEU35483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041196.1">
        <property type="nucleotide sequence ID" value="XM_003041150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKQ2"/>
    <dbReference type="GeneID" id="9675686"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51153"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51153"/>
    <dbReference type="eggNOG" id="ENOG502SMNP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045148_3_1_1"/>
    <dbReference type="InParanoid" id="C7ZKQ2"/>
    <dbReference type="OMA" id="TVGWWAM"/>
    <dbReference type="OrthoDB" id="405906at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="3">
        <location>
            <begin position="24"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU35483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="359" mass="40335" checksum="BC39B6EC05C920AA" modified="2009-10-13" version="1">MSLRLSDHPYTAKRALEGAVYTPEAVLVIVCATLAMCNAFELLCLIFMTFKRRSGLYFWSILLASFGVIPYCVGWLIVYFDFTHDYVGMIIDSVGWVLLVSGQSVVLYSRLHLVVTDARILRGVLCMIVINGVVWHTSITVLLFGSTYSPNKSKRGFNAVFNVLEKVQMTCFCIQEFIISGLYIWKTIGILKTAFGNTRRVLWQLFAINIVIVIMDIALLAIEYKNYFVWQQGIKVVIYSIKLKLEFAVLGELIDFIRHRGGTQSGSNRDYRNTGAFVELSAHKPGKDKKTATMTDPTRDDLESNTVIVASKGSPLGDGSGDEIRVVTRVDDESLNVDPRDDRSTDELYHHTIAKSTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZL34</accession>
    <name>C7ZL34_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_78309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698942">
        <property type="protein sequence ID" value="EEU35307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041020.1">
        <property type="nucleotide sequence ID" value="XM_003040974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZL34"/>
    <dbReference type="GeneID" id="9675528"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78309"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78309"/>
    <dbReference type="eggNOG" id="KOG0742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004471_2_2_1"/>
    <dbReference type="InParanoid" id="C7ZL34"/>
    <dbReference type="OMA" id="HCAYIDF"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF2">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="769"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="985"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1022"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU35307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1166" mass="131929" checksum="24847C00A52FA5B6" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLI9</accession>
    <name>C7ZLI9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_88691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698945">
        <property type="protein sequence ID" value="EEU35144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040857.1">
        <property type="nucleotide sequence ID" value="XM_003040811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLI9"/>
    <dbReference type="GeneID" id="9679271"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88691"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88691"/>
    <dbReference type="HOGENOM" id="CLU_735854_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZLI9"/>
    <dbReference type="OrthoDB" id="5068823at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="376" mass="41581" checksum="A86E99007C83C164" modified="2009-10-13" version="1">MCQACHENGPASVSGVPIASYLAKARAKQPFRLRLCHELQASIFLALNRHGAAPNLTLRDNPALCQLLWEDVGLDFAYQYRMRNTILGKLTDRAQSLLEEARKWGAFIQVGDTRCLWDNEIVAEHFSSQEKVLQWIKTKREEAAKVAREREAKEPEPGTPSRPNRASGAAFSRQTPPRASQRGLRPPQTPSRTSIRRRGPGAQTPTSSRNMGMTGQRLSRSQDTPRTRRHTFSGTIFDVPPPKMGPLEELAQSVERMGLDDSPLVNTSMRQSSGNDAQPTNLIDTLSAPQPASHRDGRLRSPIHLPTPTSTTNVGSEAQSPVANWFKVGQDTGQFPSKKPTRSHRRSSSALPGTGNQRSGGPQPMRLDLARRREPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMS5</accession>
    <name>C7ZMS5_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_19007</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698958">
        <property type="protein sequence ID" value="EEU34670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040383.1">
        <property type="nucleotide sequence ID" value="XM_003040337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMS5"/>
    <dbReference type="STRING" id="660122.C7ZMS5"/>
    <dbReference type="GeneID" id="9678830"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_19007"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_19007"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000134_18_9_1"/>
    <dbReference type="InParanoid" id="C7ZMS5"/>
    <dbReference type="OMA" id="PKEYINC"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU34670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="163" mass="17782" checksum="CCB9B9764C69C3E2" modified="2009-10-13" version="1" fragment="single">TPLGLACRRGHVDVVELLLNHHASTEVFNRTGRSPLFLAALRGHISAVKLILEKDQSSLDKAESTNTWTPLHGAVYNGHGEIVSMLLKAGSRLDTRARDGSTPLMTAIQNEREGIVKMLLVRRSEDEDLQLETRSDNEATPLGTACIRGFTTISRLLIDAGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMW7</accession>
    <name>C7ZMW7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_34796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698959">
        <property type="protein sequence ID" value="EEU34654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040367.1">
        <property type="nucleotide sequence ID" value="XM_003040321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMW7"/>
    <dbReference type="GeneID" id="9678781"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_34796"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_34796"/>
    <dbReference type="eggNOG" id="ENOG502TC6W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037239_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZMW7"/>
    <dbReference type="OMA" id="IANAMIW"/>
    <dbReference type="OrthoDB" id="4844260at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU34654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="48113" checksum="D4B6A0462854293D" modified="2009-10-13" version="1" fragment="single">FTAINNSGLPFLDELLPLANWCPTIRNALLALAGLLRVQIRQEMSLCYEDQRLPESTAALERYQVALSTLRERILALQSNNACENDALEVLGSALLLTVAGFPRTMRPEDTHEWSHHMHGMISLVESLDSSITTHSSIGRLVKESVARLDIGAFALGRTQKGHNAWLRWEIHPPETPPSPDFCALEVIMGYPKSLLTIIAAISTILEEPDDDTLSFVIDLVSRLHRQSHPVQHTTTATLHPEPALAINGIPDATLSQIESSLILWKPPKIPGRLASHMAVALTGAWEVMRKAALVYFWRGGFRGNVLAPLPPHRRDVSEHYMREIMFGLYTLLNLYKTHSITMINIMTWPLIVVGNECGGSTQLQNEVESMLRKLQQRFQIEHLKHLSPMLKELWRRFGEHGNAAEDPGHVNSLSLNSLSKELGVCLPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMY5</accession>
    <name>C7ZMY5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lysine-specific metallo-endopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_82310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698960">
        <property type="protein sequence ID" value="EEU34615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040328.1">
        <property type="nucleotide sequence ID" value="XM_003040282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMY5"/>
    <dbReference type="GeneID" id="9678758"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82310"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82310"/>
    <dbReference type="eggNOG" id="ENOG502RVZ5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_576227_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZMY5"/>
    <dbReference type="OMA" id="HEIYHCI"/>
    <dbReference type="OrthoDB" id="5023749at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002987248" description="Lysine-specific metallo-endopeptidase domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="56304" checksum="ED066C0036702405" modified="2009-10-13" version="1">MRFFLLSLLLFFLSSAQAQWSRCDKYWNLKPGDVGRKWTVKTDCHPLAGYPKQFGDTKIIVTYTRKWSQLSTKTKNAVKPVLEKSLAETFETYNKFAKLPAVIVIILTTAVDGPTTAATSNPYEKKSPFQIQMYQRWTTEATTNVPRALFAVAHELYHCVQDMKMGNARDPEYIRDGTANYFANVVFPTSNTEWPGKKFSGAEYDPAVPLYAHDGLAAYAASVFFQSMGNHRNLHSMNDWVLGTPVGFSGAAERQRLSELGSFVDTFFTFAQEFALQAIEDTSGVMIPTIPEIPPKPVSIKMSAGAASTTGTATLTTIPFTISVFKITVKTGQTVSIYSSANSYQRVAYRKSGVKDWVDMPTDATSGKPHDLPCKKGDTPVTFIVLFISSKNVKTDQVKITVKYSRPKQCGGRTGFVHYPLFNPKTSGGYCPEGTHISRTAIWCCPDGLELDEEVASQVSICCPPGKSRLFNILGMGLISAGVNCHDEIIPGNISFADKDPRMVEFYNAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNB6</accession>
    <name>C7ZNB6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_88341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698965">
        <property type="protein sequence ID" value="EEU34494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040207.1">
        <property type="nucleotide sequence ID" value="XM_003040161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNB6"/>
    <dbReference type="GeneID" id="9678040"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88341"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88341"/>
    <dbReference type="HOGENOM" id="CLU_2292397_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZNB6"/>
    <dbReference type="OrthoDB" id="4790282at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU34494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="101" mass="11554" checksum="F004E650294A1203" modified="2009-10-13" version="1">MRTDNNTKTLTTAERPAKEANFDVEKPGEVHNEYLANAQGEGDVDYSRARTEKYPEEDKPTLWLMCWLNYLDRNAIAVARLNDLEDNLGLVGCNTTRLCQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZP63</accession>
    <name>C7ZP63_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_85609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040007.1">
        <property type="nucleotide sequence ID" value="XM_003039961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZP63"/>
    <dbReference type="GeneID" id="9677646"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85609"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85609"/>
    <dbReference type="eggNOG" id="ENOG502SQII">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1180509_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZP63"/>
    <dbReference type="OMA" id="RWGFYRT"/>
    <dbReference type="OrthoDB" id="3582307at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU34294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="235" mass="27836" checksum="1CE958EE414E960A" modified="2009-10-13" version="1">MILKLWFEFNYIALPCKLASYAPFATSVLQLQTLQWRAVSRQHLKRIPDGLLFQAASKITTSSSIQDKQFCNQPPDVIHQACSTTVAHTQRLLLRWHRSLRLQKQEPSWYRDRLREELYERRQAKTLCQKLSETADVFYITSRSHHDGYPLRRLPSFAFSHLLVYAYLLPKYTLRWKFYRLAAYLCSSPNPGFVREVVNPAKDHKLHEVASRHSIDPETFARVCRRLRYFWPLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPJ0</accession>
    <name>C7ZPJ0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA-binding S4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_72284</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040070.1">
        <property type="nucleotide sequence ID" value="XM_003040024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZPJ0"/>
    <dbReference type="FunCoup" id="C7ZPJ0">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZPJ0"/>
    <dbReference type="GeneID" id="9677802"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_72284"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_72284"/>
    <dbReference type="eggNOG" id="ENOG502QTS9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026386_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZPJ0"/>
    <dbReference type="OMA" id="GDMFQVE"/>
    <dbReference type="OrthoDB" id="3356781at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="162"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU34357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="511" mass="58801" checksum="43FAC417F1EDFCC5" modified="2009-10-13" version="1">MRKPWRFYSLNRPKLRQSWNKYNLYNIARAAGREPLVKGRATFFQQKWAAKSKTRGYHGEHIPEKKWVRLFSRRLLSSVDLPPEYLAANDGSEQAAGRGSGLTTSTVTAESYSRVSQGSNKVRSLSHPAQRKSGYGDVNEMLSQHFENMTPYMQMTFAPLERRLDTAVFRAMFASSVRQARQFIIHGAVKVNGKKMVHPSYALNPGDMFQVQIEKVLYGTGEQKKPDESVKKSRESLKNKEEKTKEWGLKQRSRILEHLAAKEGESAKPSDAQLADESLDEQRAEMQVQWRRVKNLRSTAREILKGGSDLRNLSAKQKKELRLFRDTAQRFLSLPEDSKLSARDLLNEIQSQIEKLGSVESFRKADTAPSAEETEEQKLQREEKEEKELQFKTRVLEEGMDGFKDDRERARAARILAREDLTQDEIRRLAAIMRRDAENPIDDSKPYATPWRPRPYMSAFAFIPRYLEVNPNICAAVYLRHPVARKGMAEVPTPFSYLTSQLAHNWYLGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPQ5</accession>
    <name>C7ZPQ5_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SWI/SNF complex protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CHB2101</name>
        <name evidence="9" type="ORF">NECHADRAFT_122871</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039891.1">
        <property type="nucleotide sequence ID" value="XM_003039845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZPQ5"/>
    <dbReference type="FunCoup" id="C7ZPQ5">
        <property type="interactions" value="452"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZPQ5"/>
    <dbReference type="GeneID" id="9677851"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_122871"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_122871"/>
    <dbReference type="eggNOG" id="KOG1279">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004447_3_0_1"/>
    <dbReference type="InParanoid" id="C7ZPQ5"/>
    <dbReference type="OMA" id="QQFNEME"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02336">
        <property type="entry name" value="ZZ_RSC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000020">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000014">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041984">
        <property type="entry name" value="Rsc8/Ssr1/Ssr2_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032451">
        <property type="entry name" value="SMARCC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802:SF41">
        <property type="entry name" value="BRAHMA ASSOCIATED PROTEIN 155 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802">
        <property type="entry name" value="SWI/SNF COMPLEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16495">
        <property type="entry name" value="SWIRM-assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SWIRM" evidence="7">
        <location>
            <begin position="109"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="8">
        <location>
            <begin position="371"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="372"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="487"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="636"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="487"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="505"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU34178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="671" mass="73336" checksum="2BBE1C171A64B7FF" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPU0</accession>
    <name>C7ZPU0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_88034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698973">
        <property type="protein sequence ID" value="EEU33958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039671.1">
        <property type="nucleotide sequence ID" value="XM_003039625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZPU0"/>
    <dbReference type="STRING" id="660122.C7ZPU0"/>
    <dbReference type="GeneID" id="9667193"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88034"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88034"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_6_3_1"/>
    <dbReference type="InParanoid" id="C7ZPU0"/>
    <dbReference type="OMA" id="CVGYPEM"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050466">
        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024:SF643">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN B1A11.02"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024">
        <property type="entry name" value="ARYLACETAMIDE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="93"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU33958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="342" mass="37531" checksum="10D55040731C40AC" modified="2009-10-13" version="1">MAPSKETLDSSRPDPGFEQIIKNGGPPPLPHDVDIQLLRKITIEAREKDRRALGGPPPGITENDIKIPVRDGTEILARVFAPEAEGLMALPILIFFHGGGFCIGNRYDDLESNRTIAARAKVVVVSLEYRLAPEHPFPQAIHDGLDSLHWIAKNASQAHPLASPSAGIIVGGTSAGGNIANSVVYINRDQGSPAPVTGQFLSVAPLVPSPLVPDKYKEDHISPEQNKAVSIPSPELAKLFMAAYKPAITADFPTPLIHPSGHNGIPKTYLQVCGLDVLRDDSMVYERILREEAGMATRLDLYPGLPHHFWEFFPQLTTHIERRTNDTVNGVLWLVEKDREWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPV8</accession>
    <name>C7ZPV8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_55821</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698974">
        <property type="protein sequence ID" value="EEU33939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039652.1">
        <property type="nucleotide sequence ID" value="XM_003039606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZPV8"/>
    <dbReference type="STRING" id="660122.C7ZPV8"/>
    <dbReference type="GeneID" id="9667183"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55821"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55821"/>
    <dbReference type="eggNOG" id="ENOG502S5YP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079104_1_1_1"/>
    <dbReference type="InParanoid" id="C7ZPV8"/>
    <dbReference type="OMA" id="PMIHVKA"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="4">
        <location>
            <begin position="10"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU33939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="284" mass="31652" checksum="F9E5CA5E98FD7384" modified="2009-10-13" version="1">MPSLTVGLAGITGKFGRLLASKLLQSPGIHLRGYARDPSKVVPALAESPRLKLFKGEAFDDTAIKPFVTGCDVVVCAYLGTDDLMVDGQKKLIDACEEAGVPRYAYLETKKTVKGVHVLIGGFMDPIFSPLFQVWDPEAKTLRYWGEGDEPWEATSYDNAAEFTAAVIADTSAIGIKKYLGDRKSIKEIAATFQEVYGIQPKLERLGSLDDLKTQMNALRAKNPSGVFSYMFLFFMYYWLNGQTFVGPVTDNERYPEVKPETWEEFLKKRGLDELPQAYFSLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQ47</accession>
    <name>C7ZQ47_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_44551</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698982">
        <property type="protein sequence ID" value="EEU33866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039579.1">
        <property type="nucleotide sequence ID" value="XM_003039533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQ47"/>
    <dbReference type="STRING" id="660122.C7ZQ47"/>
    <dbReference type="GeneID" id="9667102"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_44551"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_44551"/>
    <dbReference type="eggNOG" id="ENOG502QUV4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_4_2_1"/>
    <dbReference type="InParanoid" id="C7ZQ47"/>
    <dbReference type="OMA" id="HADNFHD"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002989365" description="FAD-binding PCMH-type domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="181"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU33866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="649" mass="70824" checksum="B32A76005C35D945" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQ79</accession>
    <name>C7ZQ79_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 93</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_55960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698984">
        <property type="protein sequence ID" value="EEU33837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039550.1">
        <property type="nucleotide sequence ID" value="XM_003039504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQ79"/>
    <dbReference type="SMR" id="C7ZQ79"/>
    <dbReference type="GeneID" id="9667078"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55960"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55960"/>
    <dbReference type="eggNOG" id="ENOG502QW46">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036301_0_1_1"/>
    <dbReference type="InParanoid" id="C7ZQ79"/>
    <dbReference type="OMA" id="MVHQTTT"/>
    <dbReference type="OrthoDB" id="2130735at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792">
        <property type="entry name" value="BNR/ASP-BOX REPEAT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792:SF3">
        <property type="entry name" value="BNR_ASP-BOX REPEAT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002989476" evidence="1">
        <location>
            <begin position="20"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU33837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="393" mass="42554" checksum="7BED65AE934EAD7A" modified="2009-10-13" version="1">MLVKSLFLGGLLSLPAVFAAPAAAPNSLDNAPPTLVKRALPTSTFSNKVIFSPPSNAGWTDPRVLYARAIELSDGSLLSTWENYSPEPPLVYFPIFKSTDGGVSWTEIGKIEDQVNGWGLRYQPDLYELPRAIGKFPKGTIIGSGNSIPTDLSKTKIDVYASTDGGKTWKFVSSIAEGGEARPNNGLTPVWEPYMMVYKDQLVCYYSDQRDPKYGQKLVHQTTKDLLSWSALVNDVVDDNNYSARPGMPQLALLPNSQYIYVYEVCGTDGCRVHYRLSSDPLNILSAPGHSLISDKGTRPVSSPSVVWSKVGGANGSIIVSAGSQSAIFVNKNLGADGSWVEYATPQPNAYTRSLMTFKEDDNYLLIIGGGRLPPSSTNQVSLSVVKLTDLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQA2</accession>
    <name>C7ZQA2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_56027</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698986">
        <property type="protein sequence ID" value="EEU33803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039516.1">
        <property type="nucleotide sequence ID" value="XM_003039470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQA2"/>
    <dbReference type="STRING" id="660122.C7ZQA2"/>
    <dbReference type="GeneID" id="9667045"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_56027"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_56027"/>
    <dbReference type="eggNOG" id="KOG0743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010189_7_0_1"/>
    <dbReference type="InParanoid" id="C7ZQA2"/>
    <dbReference type="OMA" id="MKFASEG"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="42"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU33803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="272" mass="30334" checksum="30D5B5918643F891" modified="2009-10-13" version="1">MAARPLSIVILDKQQKEPLIKDIQDFLDPKARCWYSDYSISYKRGYLLHGPPGTGKSSFSLLVAGELDMDIYVISIPSVNDGMLKSLFADLPERCIILLEDIDAAGAACSRDFDSKDSDNGINARPKRTGVTLSGLLNVLDGVASQEDRVLIMTTNYPKNLDEALTRPGRIDKEVEFQLADRDITKDIFRFIFGQLAVQGKYDGEVEGQADEFALKVPESEFSPAEIISYLLPHRSCPAAAVENCGRWVDDLLKEKQRKRDSLQSGSRNRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQQ3</accession>
    <name>C7ZQQ3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_89276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699005">
        <property type="protein sequence ID" value="EEU33655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039368.1">
        <property type="nucleotide sequence ID" value="XM_003039322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQQ3"/>
    <dbReference type="GeneID" id="9666890"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89276"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89276"/>
    <dbReference type="HOGENOM" id="CLU_1090256_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZQQ3"/>
    <dbReference type="OrthoDB" id="4979667at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU33655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="255" mass="28832" checksum="14FE2870F3BF3194" modified="2009-10-13" version="1">MNSSFTTGPSDVESQFSTSETNVMSTIEARPLPFESMTYPIPSSSPAYPRPSSTAEGSNIEEKGSGGYIIIEGLFPRVLLPEIPNNEREYLVSCISCSYRKLEKALLLVKKNNLSFRVLSSSSFQELLSYYNKLIGFHNLTESHTGCLKISLGLEEEEPESPAFNSLISRIRRLITILKYTQEPKMLLSEAIEKYTKEGLFESEKRHIPLDNSTRWNSTYFMLRPSIKLQGQAYTTISQGLEDLQLGYNRKQDKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7YGZ8</accession>
    <name>C7YGZ8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">NECHADRAFT_31759</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="14"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053541.1">
        <property type="nucleotide sequence ID" value="XM_003053495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YGZ8"/>
    <dbReference type="FunCoup" id="C7YGZ8">
        <property type="interactions" value="512"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YGZ8"/>
    <dbReference type="GeneID" id="9664417"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_31759"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_31759"/>
    <dbReference type="eggNOG" id="KOG3359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008438_0_0_1"/>
    <dbReference type="InParanoid" id="C7YGZ8"/>
    <dbReference type="OMA" id="NCHLNAP"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097586">
        <property type="term" value="C:dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p homodimer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900101">
        <property type="term" value="P:regulation of endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23285">
        <property type="entry name" value="beta-trefoil_MIR_PMT4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000044">
        <property type="entry name" value="Dolichyl-phosphate-mannose-protein mannosyltransferase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF51">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="597"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="639"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="669"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="723"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="331"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="398"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEU47828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="772" mass="88607" checksum="1F7C5C2B650BD0FC" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHR4</accession>
    <name>C7YHR4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_73400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054398.1">
        <property type="nucleotide sequence ID" value="XM_003054352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YHR4"/>
    <dbReference type="FunCoup" id="C7YHR4">
        <property type="interactions" value="254"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YHR4"/>
    <dbReference type="GeneID" id="9664629"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_73400"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_73400"/>
    <dbReference type="eggNOG" id="KOG3429">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089470_0_0_1"/>
    <dbReference type="InParanoid" id="C7YHR4"/>
    <dbReference type="OMA" id="GGQNVNC"/>
    <dbReference type="OrthoDB" id="270639at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016150">
        <property type="term" value="F:translation release factor activity, codon nonspecific"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070126">
        <property type="term" value="P:mitochondrial translational termination"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052104">
        <property type="entry name" value="Mito_Release_Factor_mL62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075:SF54">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110916">
        <property type="entry name" value="Peptidyl-tRNA hydrolase domain-like"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="2">
        <location>
            <begin position="64"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU48685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="192" mass="22500" checksum="8B8B1E962BDEFF63" modified="2009-10-13" version="1">MMLRRQLTAVLRLRIRPLLSPPFDPRFKRYQAFDADLDQDALAEARTWFRSESELSRLPKGNTTYARSSGPGGQHVNKTETKATTAYPVRELLSTLPRLLHRSIRESKYYTTKSDSLTFHTQDSRSRDANAKENWKKLLKEILSIYDQVVPNETSKEKLQKHQDSQKNWDNQRLKMKKQLSQKKKDRRGPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>C7YI49</accession>
    <name>C7YI49_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">NECHADRAFT_90292</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053746.1">
        <property type="nucleotide sequence ID" value="XM_003053700.1"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YI49"/>
    <dbReference type="GeneID" id="9664503"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90292"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90292"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_5_1"/>
    <dbReference type="InParanoid" id="C7YI49"/>
    <dbReference type="OMA" id="EIEKWFG"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000003">
        <property type="entry name" value="Histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000099">
        <property type="entry name" value="Sensory box sensor histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF74">
        <property type="entry name" value="HISTIDINE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="PAS" evidence="17">
        <location>
            <begin position="507"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="15">
        <location>
            <begin position="804"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="16">
        <location>
            <begin position="1105"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="195"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="311"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1058"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1259"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1279"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1340"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="13">
        <location>
            <position position="1160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEU48033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1371" mass="152383" checksum="762B1E40518B0D41" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIB0</accession>
    <name>C7YIB0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_103215</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053778.1">
        <property type="nucleotide sequence ID" value="XM_003053732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIB0"/>
    <dbReference type="STRING" id="660122.C7YIB0"/>
    <dbReference type="GeneID" id="9676407"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_103215"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_103215"/>
    <dbReference type="eggNOG" id="KOG4628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031409_1_0_1"/>
    <dbReference type="InParanoid" id="C7YIB0"/>
    <dbReference type="OMA" id="TKYKQWK"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16473">
        <property type="entry name" value="RING-H2_RNF103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000539">
        <property type="entry name" value="Ring finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051826">
        <property type="entry name" value="E3_ubiquitin-ligase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765:SF434">
        <property type="entry name" value="GB|AAD18119.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765">
        <property type="entry name" value="RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="280"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="332"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU48065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="462" mass="50177" checksum="76266F4A2DD2D65D" modified="2009-10-13" version="1">MAVINQLLTEVTHIVARAAAPEDSSSTTTSSASAQTSETENRDNNNSNNGSSSPLLFFVALGFGVVFTNLWIIVGVKYCFRYNARNRAMRMNEDGEPITLENMPRPHRRRREKKLMTMDEVNDKFPMMKYKTWVSDRAREGLPTTGGVSAPPTRPNSIREADGIVPDFSAKERDSTDGRPSTSAVARGEGEATGATDTTETPTPITAAAVVADEKPKDAKPKDEKPRETTATPAENGQTSTEQTTNNNQLQRISSEDSDDDDHIDGALPPECLEAPGDTCAICIDTLEDDDDVRGLTCGHAFHAVCVDPWLTSRRACCPLCKADYYVPKPRPVPEASNDANANNGSSFDPRNNPRFNLPAAIRSAWVRGPRSANNATSTPEVPQRRRSERRPEGTEQATQPDQTPQSPEAARTSNGGVLSSVRGAFRFGRRRQEQPPNQNGAAETVTPSQLEAANRPAAAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7YID1</accession>
    <name>C7YID1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription initiation factor TFIID subunit 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_75277</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF9 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053790.1">
        <property type="nucleotide sequence ID" value="XM_003053744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YID1"/>
    <dbReference type="FunCoup" id="C7YID1">
        <property type="interactions" value="478"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YID1"/>
    <dbReference type="GeneID" id="9676416"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75277"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75277"/>
    <dbReference type="eggNOG" id="KOG3334">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068315_0_0_1"/>
    <dbReference type="InParanoid" id="C7YID1"/>
    <dbReference type="OMA" id="WNMKDEW"/>
    <dbReference type="OrthoDB" id="341924at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07979">
        <property type="entry name" value="HFD_TAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000069">
        <property type="entry name" value="Transcription initiation factor TFIID subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003162">
        <property type="entry name" value="TFIID-31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051431">
        <property type="entry name" value="TFIID_subunit_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068">
        <property type="entry name" value="TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068:SF4">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02291">
        <property type="entry name" value="TFIID-31kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="202"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU48077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="26036" checksum="81621B28A57A2039" modified="2009-10-13" version="1">MASSQPQTNGVPASSAGTSQTVPNTQTTTTSQPSASSQNAPPPAPSSSAPRPRDSRLVELLLTSQGVTAYEQRVPLLLLDFAYRHTSSVLNDALHLSGDPYVTHAGSKPSANSGAISAPAGDAAVTANAVKLAIAARLSYQFRGGSGGGGISKDYMQELARERNKVALPKIVPSEWGVRLPSERFVLSGTSWGLKDMWDEADDDEDMEGDAMEGIEGPEPEDIGGDGVEGGTVEDMFGEDVDEEMAEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIH8</accession>
    <name>C7YIH8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_31484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053811.1">
        <property type="nucleotide sequence ID" value="XM_003053765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIH8"/>
    <dbReference type="FunCoup" id="C7YIH8">
        <property type="interactions" value="1375"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YIH8"/>
    <dbReference type="GeneID" id="9676442"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_31484"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_31484"/>
    <dbReference type="eggNOG" id="KOG1889">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003016_7_4_1"/>
    <dbReference type="InParanoid" id="C7YIH8"/>
    <dbReference type="OMA" id="ITKAQPV"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072517">
        <property type="term" value="C:host cell viral assembly compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052629">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061909">
        <property type="term" value="P:autophagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="599"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="630"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="124"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU48098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="709" mass="80342" checksum="F32E89E30E1A643A" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIU8</accession>
    <name>C7YIU8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_75449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054581.1">
        <property type="nucleotide sequence ID" value="XM_003054535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIU8"/>
    <dbReference type="GeneID" id="9664703"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75449"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75449"/>
    <dbReference type="HOGENOM" id="CLU_1349271_0_0_1"/>
    <dbReference type="InParanoid" id="C7YIU8"/>
    <dbReference type="OMA" id="WAMILPI"/>
    <dbReference type="OrthoDB" id="5030096at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU48868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="203" mass="22566" checksum="31EE36E716CAD13B" modified="2009-10-13" version="1">MATTNLTTRVRLFRACTFGLWAVQFGFLLGSIAYWAFSTPASNNPKAVPSASLIILLPGLTLETVLILKTASYTPYLSSHMQWFDTSFDESTLALEILQLIWLTATIVVSRAVYMDVVVQGGPIRDIISFLRQHPPLTDSALAPRICLVYFLLSYASLVIWVWWTGFAAMVRRSIRPVQVREKEASVALTSSPAPDDKDNHGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7YK90</accession>
    <name>C7YK90_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_57229</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC10 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053414.1">
        <property type="nucleotide sequence ID" value="XM_003053368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YK90"/>
    <dbReference type="FunCoup" id="C7YK90">
        <property type="interactions" value="800"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YK90"/>
    <dbReference type="GeneID" id="9664125"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_57229"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_57229"/>
    <dbReference type="eggNOG" id="KOG3745">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008002_1_0_1"/>
    <dbReference type="InParanoid" id="C7YK90"/>
    <dbReference type="OMA" id="PLCKHHY"/>
    <dbReference type="OrthoDB" id="125856at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048625">
        <property type="entry name" value="Sec10_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20667">
        <property type="entry name" value="Sec10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec10 N-terminal" evidence="7">
        <location>
            <begin position="58"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec10-like alpha-helical bundle" evidence="6">
        <location>
            <begin position="191"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU47701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="844" mass="94631" checksum="BD1283510807FD90" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7YKF1</accession>
    <name>C7YKF1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7707 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_98720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054158.1">
        <property type="nucleotide sequence ID" value="XM_003054112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YKF1"/>
    <dbReference type="GeneID" id="9664164"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_98720"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98720"/>
    <dbReference type="eggNOG" id="ENOG502SSWV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084512_1_1_1"/>
    <dbReference type="InParanoid" id="C7YKF1"/>
    <dbReference type="OMA" id="CSAQRNT"/>
    <dbReference type="OrthoDB" id="2121879at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056124">
        <property type="entry name" value="DUF7707"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38118:SF3">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38118">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24808">
        <property type="entry name" value="DUF7707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988446" description="DUF7707 domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7707" evidence="3">
        <location>
            <begin position="31"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU48445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="204" mass="21062" checksum="E72D3BA2AA00B097" modified="2009-10-13" version="1">MRSTLAFLALAVSAVTAQTTTVQDYDSSLNMTIDPGTVEFGTRAGWCNAQQDTCDTLCKDDTEENDCTAETLVWECACSSNSSTPGLQYYTQTMPTFICQELFAQCISQNAGSQSGQRDCKSKIQALCATQSPPKNTASDDDDDDATTTLTSATRSATGTAASASATEDTVTSTSSDGFAAPTMAPAGGAAAAAAALGMLAYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7YKF8</accession>
    <name>C7YKF8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_74594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053439.1">
        <property type="nucleotide sequence ID" value="XM_003053393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YKF8"/>
    <dbReference type="STRING" id="660122.C7YKF8"/>
    <dbReference type="GeneID" id="9676771"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74594"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74594"/>
    <dbReference type="eggNOG" id="KOG2483">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017046_0_0_1"/>
    <dbReference type="InParanoid" id="C7YKF8"/>
    <dbReference type="OMA" id="MAHASTD"/>
    <dbReference type="OrthoDB" id="8964853at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU47726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="361" mass="38680" checksum="0C825B2560995BFE" modified="2009-10-13" version="1">MDAHSQQRPPAPKSAGLTNILNSEHASASAPNGPPHMRDSGFYSNADASTSFNVNGLSPSGSGYQSSSQDKTPSPIASNMVPHALVSPSTTNMSVAAMVSPSTPGNLDPRRDRPTSIESNGTGPVMGETLAPGMGGLRRESVDSRINQGFSDMRLGNSPYTSNNPSTTSIQNTLHTQRNPHHLSVHRISNGYQPSADRNPESKTIKTAPAITGPATGHIARAAEPTKGQAWAFPEEEIQPFRDRGANTAAAIAEHQRLNDHNRLLQSHYNTAMADNEILRRELNALRMEGVQLRGDINTSSGHPPPPPPAAPHSGPYPSDPYASSTRPELPPIRSLNNGPDSMTGVQYDTPRVNGYRQERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7YKJ0</accession>
    <name>C7YKJ0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Post-GPI attachment to proteins factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_74627</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the lipid remodeling steps of GPI-anchor maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PGAP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054174.1">
        <property type="nucleotide sequence ID" value="XM_003054128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YKJ0"/>
    <dbReference type="FunCoup" id="C7YKJ0">
        <property type="interactions" value="178"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YKJ0"/>
    <dbReference type="GeneID" id="9676791"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74627"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74627"/>
    <dbReference type="eggNOG" id="KOG2970">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032917_1_1_1"/>
    <dbReference type="InParanoid" id="C7YKJ0"/>
    <dbReference type="OMA" id="DFMIEDC"/>
    <dbReference type="OrthoDB" id="419770at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007217">
        <property type="entry name" value="Per1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148">
        <property type="entry name" value="PER1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148:SF0">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04080">
        <property type="entry name" value="Per1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 7" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016484744" description="Post-GPI attachment to proteins factor 3" evidence="7">
        <location>
            <begin position="29"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU48461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="312" mass="36374" checksum="D679D1ED54118A56" modified="2009-10-13" version="1">MAAQRGRPWTQVLSLTVLILAFVATVGASTGDKWPEFQNCLKVCNSQNCAPNKPQTPIPVLHRLLFWNCASECDYACQHIITNKRMAKGLSVEQFYGKWPFYRFLGMQEPFSVLFSLGNLWAHWDGWNKVRAQIPKSYSMLPFYEWLAGIGVASWVFSSIFHTRDFPVTEELDYFGAGASVLYGLYYTTVRVFRLDKRTPRRRTVLRCWTLVCVFLYICHVCYLKFIHWDYTYNMAANVAAGIGQNALWTWFSIDRYRKSRRIWAAWPGFVVAWVIFAMSMELFDFPPWLGCIDAHSLWHLMTIGPTILWYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>C7YKN6</accession>
    <name>C7YKN6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_31723</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053484.1">
        <property type="nucleotide sequence ID" value="XM_003053438.1"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YKN6"/>
    <dbReference type="GeneID" id="9676816"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_31723"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_31723"/>
    <dbReference type="eggNOG" id="KOG0059">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001640_2_0_1"/>
    <dbReference type="InParanoid" id="C7YKN6"/>
    <dbReference type="OMA" id="TYFEEHT"/>
    <dbReference type="OrthoDB" id="8061355at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF36">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="955"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="999"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1031"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1063"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1096"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1139"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="437"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="1210"/>
            <end position="1433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU47771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1537" mass="169233" checksum="CA6209CF1A21B2D5" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7YKY4</accession>
    <name>C7YKY4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_36802</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052413.1">
        <property type="nucleotide sequence ID" value="XM_003052367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YKY4"/>
    <dbReference type="GeneID" id="9670945"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_36802"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_36802"/>
    <dbReference type="eggNOG" id="ENOG502SK2W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027816_3_0_1"/>
    <dbReference type="InParanoid" id="C7YKY4"/>
    <dbReference type="OMA" id="WIGINAC"/>
    <dbReference type="OrthoDB" id="294730at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF479">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="54"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU46700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="471" mass="50868" checksum="F1F7F3DB51CC003B" modified="2009-10-13" version="1">MEKNEIAEQNQGDHSDTTDHEGLDHKPVYSDADEGEVDVFGGEGGANFRTMGRFDTVFALLTNQFGLGALALPSVFKTLGLIPGLITLIGGALITYFSGVEIFWYYVAHPKVTNIAEMMKIVGGRPAEIFCGIGLLLQLIMTAASAVVTISIALNAISEHAVCTVGYIAIACILCFMLCIPRTAKFLAQSGLPCILSILAAALSTIIGLGIKNPPGAPEGWKPEIELFGTPTLREVLNGVLKILFALAGNYAFVTYMAEMKDPKKDFIYSLRWLMVASVVFYAFIAIAVYCLAAEFTSSPALSSAPIVAAKVAYGLVLPAILTDGLACGHIGTKYVYITIMRQINALKEVTANTPKAWGTWIGSNAAFWVIVFILSNTIPVFDSIVAVSSATTYAWFTYGISAFLWLHLYKGRYFEDWWSIMLFIANIGFIVFSLFLNGGGTWSSITALLDIFATSDNIRGCFSCGDNAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLB4</accession>
    <name>C7YLB4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ABC transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NECHADRAFT_77470</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052471.1">
        <property type="nucleotide sequence ID" value="XM_003052425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YLB4"/>
    <dbReference type="GeneID" id="9663634"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77470"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77470"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_17_2_1"/>
    <dbReference type="InParanoid" id="C7YLB4"/>
    <dbReference type="OMA" id="CIHGGTL"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001530">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000967">
        <property type="entry name" value="ABC multidrug transporter mdr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000057">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF11">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="674"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="716"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="785"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="816"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="901"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="933"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="28"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="354"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="677"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="998"/>
            <end position="1239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU46758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1244" mass="135413" checksum="37B07EB06099198A" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLN4</accession>
    <name>C7YLN4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Nuclear transport factor 2</fullName>
            <shortName evidence="4">NTF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_67151</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Facilitates protein transport into the nucleus. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053011.1">
        <property type="nucleotide sequence ID" value="XM_003052965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YLN4"/>
    <dbReference type="FunCoup" id="C7YLN4">
        <property type="interactions" value="1195"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YLN4"/>
    <dbReference type="GeneID" id="9671055"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_67151"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_67151"/>
    <dbReference type="eggNOG" id="KOG2104">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131642_0_0_1"/>
    <dbReference type="InParanoid" id="C7YLN4"/>
    <dbReference type="OMA" id="QFVEYYY"/>
    <dbReference type="OrthoDB" id="6507044at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000005">
        <property type="entry name" value="Nuclear transport factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="5">
        <location>
            <begin position="8"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00053082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU47298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="125" mass="14053" checksum="3AB05334208498D3" modified="2009-10-13" version="1">MANNFEEVAKQFIEFYYNTFDSDRKALAALYRPESMLTFESASVLGAEPIIEKLTSLPFEKVKHQVNTLDAQPSNGEGGIIILITGALLVDEEQRPMNFSQSFQLARDAGGNYFVYNDIFKLVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLW0</accession>
    <name>C7YLW0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-structural maintenance of chromosomes element 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_5514</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the SMC5-SMC6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NSE4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053054.1">
        <property type="nucleotide sequence ID" value="XM_003053008.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YLW0"/>
    <dbReference type="STRING" id="660122.C7YLW0"/>
    <dbReference type="GeneID" id="9663895"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_5514"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_5514"/>
    <dbReference type="eggNOG" id="KOG2866">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041037_4_0_1"/>
    <dbReference type="InParanoid" id="C7YLW0"/>
    <dbReference type="OMA" id="FMGINRT"/>
    <dbReference type="OrthoDB" id="361242at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027786">
        <property type="entry name" value="Nse4/EID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014854">
        <property type="entry name" value="Nse4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029225">
        <property type="entry name" value="Nse4_Nse3-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15412">
        <property type="entry name" value="Nse4-Nse3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08743">
        <property type="entry name" value="Nse4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nse4/EID protein Nse3/MAGE-binding" evidence="10">
        <location>
            <begin position="62"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Non-structural maintenance of chromosome element 4 C-terminal" evidence="9">
        <location>
            <begin position="262"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="109"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU47341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="368" mass="42042" checksum="8DF8FCD6746D5671" modified="2009-10-13" version="1" fragment="single">YDPDQPLEERRKVQQGFRDLLREVTENTEEYLQSDSRGLHDAILRADELSKKVRQTTEATIDSRLLVSTTDLSYRKTLRLTQGSLSQGLDVDEFVSKCITYMRQGRGIIDDNAPELSSTQRQRRRPTRGDEDGEDDVGDDGDMMNWPHLGRFASLPYIRRPALPGFLLGPLSVEKKARKITKRSAPFRPNNLTETRPEVLNVEDLAKRENDLTAICGKILHQLQNIQADIQQTVMDLIDDDMDEDEKTRIMHNHGLRSTGGIDLMRFVVNPKSFGQTIENMFYVSFLIRDGRVEIDFDEFGLPALAPVDREVEEEEPTRHGAAKHQAILSMDMETWRDIIDTFGLQEPMIAHRKEATNTGPGARGWYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7YM83</accession>
    <name>C7YM83_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_59142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052612.1">
        <property type="nucleotide sequence ID" value="XM_003052566.1"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_59142"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UNVRSLSTRESS"/>
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            <begin position="441"/>
            <end position="638"/>
        </location>
    </feature>
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        <location>
            <begin position="20"/>
            <end position="142"/>
        </location>
    </feature>
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            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
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            <begin position="250"/>
            <end position="335"/>
        </location>
    </feature>
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            <begin position="525"/>
            <end position="556"/>
        </location>
    </feature>
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        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
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        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
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        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU46899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="670" mass="72603" checksum="94BACD339539C329" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="6">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">NECHADRAFT_78229</name>
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        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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            <taxon>Fusarium vanettenii</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <text evidence="3">Belongs to the SSK1 family.</text>
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    <dbReference type="GeneID" id="9664406"/>
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    </dbReference>
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    <dbReference type="InParanoid" id="C7YNH2"/>
    <dbReference type="OMA" id="STEYDTH"/>
    <dbReference type="OrthoDB" id="21225at2759"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0000156">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
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        <property type="entry name" value="PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK1-RELATED"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="801"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <begin position="283"/>
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        </location>
    </feature>
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        <location>
            <begin position="509"/>
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        </location>
    </feature>
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        <location>
            <begin position="564"/>
            <end position="644"/>
        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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        <location>
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    </feature>
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            <position position="698"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEU47119.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="851" mass="90897" checksum="321ADDFE31B102CB" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNN3</accession>
    <name>C7YNN3_FUSV7</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_73622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052316.1">
        <property type="nucleotide sequence ID" value="XM_003052270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNN3"/>
    <dbReference type="GeneID" id="9670838"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_73622"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_73622"/>
    <dbReference type="eggNOG" id="ENOG502T6ZE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_172699_0_0_1"/>
    <dbReference type="InParanoid" id="C7YNN3"/>
    <dbReference type="OMA" id="SRSWFKA"/>
    <dbReference type="OrthoDB" id="5089392at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU46603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="94" mass="10417" checksum="ED93BB47256FEA6B" modified="2009-10-13" version="1">MTFGRTRTSSSEEQRGRNPEPVPIMDDKQRTNSYSSEASFPESPASSPPKSSHSWFKPAPQAVNVYTTCGRHTNQLLFGGPSLTELARSMLKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7YP93</accession>
    <name>C7YP93_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_92458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051972.1">
        <property type="nucleotide sequence ID" value="XM_003051926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YP93"/>
    <dbReference type="GeneID" id="9673125"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_92458"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_92458"/>
    <dbReference type="eggNOG" id="ENOG502REFA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1038450_0_0_1"/>
    <dbReference type="InParanoid" id="C7YP93"/>
    <dbReference type="OMA" id="VTPACHI"/>
    <dbReference type="OrthoDB" id="4978182at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU46259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="260" mass="28889" checksum="9836A80712953025" modified="2009-10-13" version="1">MDSFVNHPSSLSLSPSAMDVDASRRTPSPVPSLGHDSLSTPTTEMTTPPIFSSAFAVVKGSEPAGRLSIMEQPDMRNPVNGWASPSFPKDQKPRLPVIGGTPDFLILYCFNIRRAADFYSRCFGWKFYGDMNAREIDDPSKRQWGSSFFDVQPMNFFNSSEDKGQLKITGALVQMRTTPDSQARLEHKRQMARFGAATPTCHLRVPDLGDAEELIEQNFGEVKHLRYGIRQFIMDVGEFIDTEGNLVGLISLHPENANAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPB0</accession>
    <name>C7YPB0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_103997</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051980.1">
        <property type="nucleotide sequence ID" value="XM_003051934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YPB0"/>
    <dbReference type="FunCoup" id="C7YPB0">
        <property type="interactions" value="746"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YPB0"/>
    <dbReference type="GeneID" id="9673133"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_103997"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_103997"/>
    <dbReference type="eggNOG" id="KOG0832">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040318_4_2_1"/>
    <dbReference type="InParanoid" id="C7YPB0"/>
    <dbReference type="OMA" id="TNTGHEH"/>
    <dbReference type="OrthoDB" id="2320368at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_uS2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_uS2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S2 PROKARYOTIC AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU46267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="59127" checksum="876C3EBE02305742" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPJ6</accession>
    <name>C7YPJ6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Selenoprotein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_68134</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SELO family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051571.1">
        <property type="nucleotide sequence ID" value="XM_003051525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YPJ6"/>
    <dbReference type="FunCoup" id="C7YPJ6">
        <property type="interactions" value="338"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YPJ6"/>
    <dbReference type="GeneID" id="9673249"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_68134"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_68134"/>
    <dbReference type="eggNOG" id="KOG2542">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010245_2_1_1"/>
    <dbReference type="InParanoid" id="C7YPJ6"/>
    <dbReference type="OMA" id="YGPYGWL"/>
    <dbReference type="OrthoDB" id="10254721at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070733">
        <property type="term" value="F:AMPylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00692">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057:SF14">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="270"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU45858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="641" mass="72531" checksum="D0D3AF7AC94D6D8A" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPP6</accession>
    <name>C7YPP6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_78826</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052041.1">
        <property type="nucleotide sequence ID" value="XM_003051995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YPP6"/>
    <dbReference type="STRING" id="660122.C7YPP6"/>
    <dbReference type="GeneID" id="9668754"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78826"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78826"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011025_2_1_1"/>
    <dbReference type="InParanoid" id="C7YPP6"/>
    <dbReference type="OMA" id="KIFTHPP"/>
    <dbReference type="OrthoDB" id="413885at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.10">
        <property type="entry name" value="Cholesterol Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053208">
        <property type="entry name" value="GMC_Oxidoreductase_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190:SF4">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988194" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU46328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="551" mass="59118" checksum="16B2E3B5E4C20576" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQ86</accession>
    <name>C7YQ86_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_100057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052141.1">
        <property type="nucleotide sequence ID" value="XM_003052095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQ86"/>
    <dbReference type="ESTHER" id="nech7-c7yq86">
        <property type="family name" value="Haloperoxidase"/>
    </dbReference>
    <dbReference type="GeneID" id="9673444"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100057"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100057"/>
    <dbReference type="eggNOG" id="ENOG502RZTA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_12_0_1"/>
    <dbReference type="InParanoid" id="C7YQ86"/>
    <dbReference type="OMA" id="HWCYWEK"/>
    <dbReference type="OrthoDB" id="2498029at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="35"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU46428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="306" mass="33855" checksum="00E78AE67737500D" modified="2009-10-13" version="1">MHLETFTTNDGCKIAYQSSLPLSAAAGNASSRHCVVLMHGFSGSSDYFNRNIGPLSESLWVVAPDMRGHGRSDRTRGGYHVARLAADLAGLVAHLRKAVPDTRIVPVGCSIGAAVLWTYIELFGCTEFAGFVFVDQAPLQDRSTFDDWDKSKAHTGCYDEATMLVAQKSWIEESKSAHIDLVKGCLGYRHAPQHEDGVSAEQAASDEAFFTEISALCDQTWLARLLADHTRYDHREAIETITVPTLVMAGRRSGCFPLEGMLETAKRVEKTRPGLAKSSVFESGHWLFYEEPDRFNKEIDDFVRSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQD5</accession>
    <name>C7YQD5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_100079</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052161.1">
        <property type="nucleotide sequence ID" value="XM_003052115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQD5"/>
    <dbReference type="FunCoup" id="C7YQD5">
        <property type="interactions" value="128"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YQD5"/>
    <dbReference type="GeneID" id="9668949"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100079"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100079"/>
    <dbReference type="eggNOG" id="KOG3140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041954_0_0_1"/>
    <dbReference type="InParanoid" id="C7YQD5"/>
    <dbReference type="OMA" id="KWQALET"/>
    <dbReference type="OrthoDB" id="166803at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="12">
        <location>
            <begin position="149"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU46448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="382" mass="41539" checksum="184F4F4464A0BEF5" modified="2009-10-13" version="1">MPADYHSTAQALALSPDRSTPSPSPNRPPWATDSTSHTRRLSNPLMRRRRSSVVAGASPGFARRIWASVNLLGEQTLKVYLRMSPLQRLLAALGAVVIAVLGVLAIIFSHAFFKWLDPVAEKWRALPGGWILAFLLVFVTSFPPVMGYSTASTIAGYVYGFPWGWPIVASGCTLGALCAFLASRTVLSGYVDRMVGRDHRFIALGQVLRQEGIWYLTAIRFCPLPFSLSNGFLATIPSITPLSFTLSTALSSPKLLVHVFIGSRIALLAEKGDTMTAGDKAINYLSMLIGATVGLVVGLVIYRRTMARAAELAREEGLDPAALATTEEGEAGYLDSDNSPLMDPEDAAVLMSDDDISLWERDGLENGYHDDDDDEESSKRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7YS41</accession>
    <name>C7YS41_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_93753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051286.1">
        <property type="nucleotide sequence ID" value="XM_003051240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YS41"/>
    <dbReference type="GeneID" id="9668133"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_93753"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_93753"/>
    <dbReference type="eggNOG" id="ENOG502SQ4J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057711_1_0_1"/>
    <dbReference type="InParanoid" id="C7YS41"/>
    <dbReference type="OMA" id="DPFHTNF"/>
    <dbReference type="OrthoDB" id="3009728at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU45573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="341" mass="37971" checksum="D017D446057CCFAC" modified="2009-10-13" version="1">MPRPTLHTGRLGLLFVVLIILSWDSIIKEQLKNDCVPEITNYRNRSETKPQTGYQVIDCILRTTPEFRKAELAASTVILGLAPAVLQLLSASYVDTAVLAFRRPGLALLLAMSSSGVRPLSATEYEDFIAKMGTDPFRTNFGNPHSFWAPRAVSAVEYFIVCASVANNAYLAYQLSVWAVCTFAPANDFLPAIWTAASVVIHLIGYLVARLRIKVEGKDDISLRSSEWRWLWNELTPTPWQSRLEVKSDTKETGWFLVLISVLYVGTALQAFYGTIILSSLVFLSVRDSAIVVLRLLASALFARGILIYELAGFRTDREGHGPSEKSEYTMVEMRALARSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSB9</accession>
    <name>C7YSB9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein BZZ1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NECHADRAFT_41749</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a role in endocytosis and trafficking to the vacuole. Functions with type I myosins to restore polarity of the actin cytoskeleton after NaCl stress.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the BZZ1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051322.1">
        <property type="nucleotide sequence ID" value="XM_003051276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSB9"/>
    <dbReference type="FunCoup" id="C7YSB9">
        <property type="interactions" value="347"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YSB9"/>
    <dbReference type="GeneID" id="9666178"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_41749"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_41749"/>
    <dbReference type="eggNOG" id="KOG3565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015390_1_0_1"/>
    <dbReference type="InParanoid" id="C7YSB9"/>
    <dbReference type="OMA" id="YADGWWE"/>
    <dbReference type="OrthoDB" id="8783038at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045010">
        <property type="term" value="P:actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20824">
        <property type="entry name" value="C1_SpBZZ1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11912">
        <property type="entry name" value="SH3_Bzz1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000060">
        <property type="entry name" value="Actin polymerization protein Bzz1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000161">
        <property type="entry name" value="Actin polymerization protein Bzz1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000296">
        <property type="entry name" value="Actin polymerization protein Bzz1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000040">
        <property type="entry name" value="Actin polymerization protein Bzz1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035459">
        <property type="entry name" value="Bzz1_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF21">
        <property type="entry name" value="PROTEIN NERVOUS WRECK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="F-BAR" evidence="14">
        <location>
            <begin position="8"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="13">
        <location>
            <begin position="405"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="575"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="677"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="452"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="635"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="128"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="321"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="459"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="482"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="506"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="635"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU45609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="735" mass="81513" checksum="EFC93281098E96AF" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSE3</accession>
    <name>C7YSE3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosducin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_41038</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051334.1">
        <property type="nucleotide sequence ID" value="XM_003051288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSE3"/>
    <dbReference type="FunCoup" id="C7YSE3">
        <property type="interactions" value="499"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YSE3"/>
    <dbReference type="GeneID" id="9666190"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_41038"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_41038"/>
    <dbReference type="eggNOG" id="KOG3170">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072604_1_0_1"/>
    <dbReference type="InParanoid" id="C7YSE3"/>
    <dbReference type="OMA" id="FCEIRAN"/>
    <dbReference type="OrthoDB" id="45518at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071444">
        <property type="term" value="P:cellular response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903333">
        <property type="term" value="P:negative regulation of protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02988">
        <property type="entry name" value="Phd_like_VIAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051498">
        <property type="entry name" value="Phosducin-like_chap/apop_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809:SF3">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="3">
        <location>
            <begin position="71"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU45621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="260" mass="29294" checksum="7166281A195BB741" modified="2009-10-13" version="1">MAAPSEQRIAVPIDDPNADTEWNDILRKHGVIPEKPPSPTPMIEEAILEGRRLAHENRLEGKDLDELDELEDEEDEAFLELYRQKRMAELSNLQKKALHGSVYPISKPEYQREVTDASKNGPVFVNLTSSMGTNVESRVLTELWRQAAKEYGEIKFCEIRASQAIENYPDRNCPTILVYKNGDIVKQIVTLMTIGGVRTNMSKIDNLLVEVGAVPDSDMRVIKRRQAAEDAEEERLAGKTIKTGTAGKSRNVDSDDDDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSI5</accession>
    <name>C7YSI5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_80748</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050964.1">
        <property type="nucleotide sequence ID" value="XM_003050918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSI5"/>
    <dbReference type="STRING" id="660122.C7YSI5"/>
    <dbReference type="GeneID" id="9668282"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_80748"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_80748"/>
    <dbReference type="eggNOG" id="ENOG502SMC3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_3_4_1"/>
    <dbReference type="InParanoid" id="C7YSI5"/>
    <dbReference type="OMA" id="WATVDIA"/>
    <dbReference type="OrthoDB" id="3936451at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF96">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="27"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="319"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU45251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="392" mass="44048" checksum="EC4A970F19CEAB39" modified="2009-10-13" version="1">MAVENRGPELQAVCYTLATAAIISTLLRCFVRVRLVKNFGFDDWCMCTALCSFLLFVICALIGVHYGTGRHHKDLDPEDIKQAMKYWWWCYLWYCTSMIASKISIGYFLLRITVRKMDVWIIYGVMMITVCTGLVFFFVTLFQCRPISFFWNKDQNGTCVNVEVIIALTYLYSVFSVISDFTCAILPMFLVWKLNMGRKTKIALIPIMAMACVASSAVVVRFAFVKDFKSPDFLWATLDIAIWSTTEQGLAVTAGSLATLRPLLRLLGHKLGISTSGPSVLQDTDQPIASGGFKSKGTDGSGNRHRSLFSLTTFTREDDLNGHGRDSEAAYAGRSHFDRPGPEKSVWGTRTSVENESEEELTRMGQQHNKGLSGDSQRIVKVTTFQVQEDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C7YU63</accession>
    <name>C7YU63_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U3 small nucleolar RNA-associated protein 13 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_96240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ASTRA complex involved in chromatin remodeling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698900">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003050413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YU63"/>
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        <property type="interactions" value="1052"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YU63"/>
    <dbReference type="GeneID" id="9665432"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_96240"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_96240"/>
    <dbReference type="eggNOG" id="KOG0319">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009276_0_0_1"/>
    <dbReference type="InParanoid" id="C7YU63"/>
    <dbReference type="OMA" id="PYVQRHF"/>
    <dbReference type="OrthoDB" id="5414888at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013934">
        <property type="entry name" value="Utp13_C"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF15">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08625">
        <property type="entry name" value="Utp13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="107"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="221"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="269"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="419"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="533"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="608"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="659"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="682"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 13 C-terminal" evidence="8">
        <location>
            <begin position="735"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU44746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="899" mass="97895" checksum="F020E61F7A4543DF" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7YUB5</accession>
    <name>C7YUB5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sacsin/Nov domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_84864</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050487.1">
        <property type="nucleotide sequence ID" value="XM_003050441.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9674882"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84864"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84864"/>
    <dbReference type="eggNOG" id="ENOG502QPMA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001744_1_0_1"/>
    <dbReference type="InParanoid" id="C7YUB5"/>
    <dbReference type="OMA" id="VYWWVIL"/>
    <dbReference type="OrthoDB" id="10031156at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022155">
        <property type="entry name" value="DUF3684"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
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        <property type="entry name" value="SACS/Nov_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047352">
        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12449">
        <property type="entry name" value="DUF3684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25794">
        <property type="entry name" value="SACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacsin/Nov" evidence="2">
        <location>
            <begin position="27"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1414"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1508"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1738"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1414"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1431"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1527"/>
            <end position="1536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU44774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1765" mass="195483" checksum="AA805212CB054F5B" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7YUR2</accession>
    <name>C7YUR2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GTPase-activating protein GYP7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">GAP for YPT7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_48931</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050169.1">
        <property type="nucleotide sequence ID" value="XM_003050123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YUR2"/>
    <dbReference type="FunCoup" id="C7YUR2">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YUR2"/>
    <dbReference type="GeneID" id="9674954"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_48931"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_48931"/>
    <dbReference type="eggNOG" id="KOG2197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004457_0_0_1"/>
    <dbReference type="InParanoid" id="C7YUR2"/>
    <dbReference type="OMA" id="WWREQRG"/>
    <dbReference type="OrthoDB" id="10264062at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000032">
        <property type="entry name" value="GTPase activating protein (Gyp7)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TBC1 domain family member 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021935">
        <property type="entry name" value="SGSM1/2_RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF502">
        <property type="entry name" value="SMALL G PROTEIN SIGNALING MODULATOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12068">
        <property type="entry name" value="PH_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="446"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="746"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="751"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00072091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00082648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU44456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="821" mass="93379" checksum="D1272513F08AE70F" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVF9</accession>
    <name>C7YVF9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ysc84 actin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_85262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050684.1">
        <property type="nucleotide sequence ID" value="XM_003050638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVF9"/>
    <dbReference type="STRING" id="660122.C7YVF9"/>
    <dbReference type="GeneID" id="9674714"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85262"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85262"/>
    <dbReference type="eggNOG" id="KOG1843">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015320_1_0_1"/>
    <dbReference type="InParanoid" id="C7YVF9"/>
    <dbReference type="OMA" id="PTATGDH"/>
    <dbReference type="OrthoDB" id="10255128at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11524">
        <property type="entry name" value="SYLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF8">
        <property type="entry name" value="DUF500 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G07310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84 actin-binding" evidence="1">
        <location>
            <begin position="80"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU44971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="229" mass="24116" checksum="32D0EA1B6E415439" modified="2009-10-13" version="1">MGFFKAADIRHECDKAAQILKSFVEKSKIPSDVIAGAQGLAIFTGFRAGMYLAGAGGSGIVVARLPDGTWSPPSAFSVRSGSIGLVYGLDVYDCVCVLNTQAAVDAYKTSEMSLGGAVALAAGPIGGTANVKEVKPVWTYTKSRGLYGGLTVDGTIIKERRDANADFYGSSVSSKQILEGHAEIVDGFHDWRAGAKQLIEVLKTAEGKQGDVKILQEISDQPTPGDLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVP0</accession>
    <name>C7YVP0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_89599</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU43825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049538.1">
        <property type="nucleotide sequence ID" value="XM_003049492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVP0"/>
    <dbReference type="GeneID" id="9677320"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89599"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89599"/>
    <dbReference type="eggNOG" id="ENOG502SJEB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011777_2_0_1"/>
    <dbReference type="InParanoid" id="C7YVP0"/>
    <dbReference type="OMA" id="EVRKWVF"/>
    <dbReference type="OrthoDB" id="5344325at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF6">
        <property type="entry name" value="PROLINE UTILIZATION TRANS-ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="369"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="94"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="190"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU43825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="778" mass="85837" checksum="253133522949469C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C7YW09</accession>
    <name>C7YW09_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase PEP5</fullName>
            <ecNumber evidence="9">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_102948</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex. Component of the class C core vacuole/endosome tethering (CORVET) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the VPS11 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="9"/>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU43884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049597.1">
        <property type="nucleotide sequence ID" value="XM_003049551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YW09"/>
    <dbReference type="FunCoup" id="C7YW09">
        <property type="interactions" value="581"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YW09"/>
    <dbReference type="GeneID" id="9677172"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102948"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102948"/>
    <dbReference type="eggNOG" id="KOG2114">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001287_0_0_1"/>
    <dbReference type="InParanoid" id="C7YW09"/>
    <dbReference type="OMA" id="ENENECP"/>
    <dbReference type="OrthoDB" id="26184at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033263">
        <property type="term" value="C:CORVET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16688">
        <property type="entry name" value="RING-H2_Vps11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000440">
        <property type="entry name" value="E3 ubiquitin-protein ligase PEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057308">
        <property type="entry name" value="CHCR_PEP5_VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057307">
        <property type="entry name" value="PEP5_VPS11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016528">
        <property type="entry name" value="VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024763">
        <property type="entry name" value="VPS11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF24">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23341">
        <property type="entry name" value="PEP5_VPS11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23356">
        <property type="entry name" value="TPR_PEP5_VPS11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12451">
        <property type="entry name" value="VPS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007860">
        <property type="entry name" value="VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0926">Vacuole</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="CHCR" evidence="11">
        <location>
            <begin position="407"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="848"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR007860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU43884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="940" mass="105270" checksum="BC4547CA3F45C501" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWG6</accession>
    <name>C7YWG6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_89795</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049888.1">
        <property type="nucleotide sequence ID" value="XM_003049842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWG6"/>
    <dbReference type="FunCoup" id="C7YWG6">
        <property type="interactions" value="896"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YWG6"/>
    <dbReference type="GeneID" id="9677486"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89795"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89795"/>
    <dbReference type="eggNOG" id="KOG0373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_8_3_1"/>
    <dbReference type="InParanoid" id="C7YWG6"/>
    <dbReference type="OMA" id="MCLKVKY"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903432">
        <property type="term" value="P:regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="206"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="104"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU44175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="404" mass="44469" checksum="1CB7286D9852962F" modified="2009-10-13" version="1">MAASVPRPGPANLGPNAGLDEWLEEAKQCHYLPERAMKELCEKVKEILMEESNIQPVCTPVTVCGDIHGQFYDLLELFRVSGGMPGESNVQAPKTATTVITSDDIEPPTEITNPKLRKKIKASGDGAATSGAEGEEGEGDDAEEDPDATVADRLDSGVAVTASSSQSADTRYIFLGDFVDRGYFSLETFTLLMCLKAKYPDRIVLVRGNHESRQITQVYGFYEECQQKYGNASVWKACCHVFDFLVLAAIIDGEILCVHGGLSPEIRTIDQIRVVARAQEIPHEGAFCDLVWSDPEDVETWAISPRGAGWLFGDKVATEFNHVNGLKLIARAHQLVNEGYKYHFPENSVVTVWSAPNYCYRCGNVASIMAVDKDLNPKFSIFSAVPDDQRHVPANRRGPGDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWI6</accession>
    <name>C7YWI6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">IPT/TIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_89812</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the NRARP family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU43964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049677.1">
        <property type="nucleotide sequence ID" value="XM_003049631.1"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YWI6"/>
    <dbReference type="GeneID" id="9677252"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89812"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89812"/>
    <dbReference type="eggNOG" id="KOG3836">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002768_0_0_1"/>
    <dbReference type="InParanoid" id="C7YWI6"/>
    <dbReference type="OMA" id="HPMMRRI"/>
    <dbReference type="OrthoDB" id="71307at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019208">
        <property type="term" value="F:phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00102">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051226">
        <property type="entry name" value="PP1_Regulatory_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057962">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179:SF21">
        <property type="entry name" value="MYOSIN BINDING SUBUNIT, ISOFORM O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25603">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1333"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="7">
        <location>
            <begin position="776"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="962"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="995"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="47"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="159"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="401"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="580"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1047"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1082"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="580"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="653"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1055"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1092"/>
            <end position="1110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU43964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1389" mass="150953" checksum="C135F657E462DC3F" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWS3</accession>
    <name>C7YWS3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_82765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049168.1">
        <property type="nucleotide sequence ID" value="XM_003049122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWS3"/>
    <dbReference type="GeneID" id="9666555"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82765"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82765"/>
    <dbReference type="eggNOG" id="ENOG502T0CR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090390_0_0_1"/>
    <dbReference type="InParanoid" id="C7YWS3"/>
    <dbReference type="OMA" id="ACFCTQE"/>
    <dbReference type="OrthoDB" id="5398531at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988323" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU43455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="28109" checksum="45E7E748F3AE6822" modified="2009-10-13" version="1">MLLFTRPAVALTLVLSSLTVCHGAVFKAPKCVGDITEFPNCMKADEIARKCSNKSKQETIDCFCTQELLDAYVGCKGEFRQCVLGNSYDSFVEDEIANWQDACGPYLPDDITTPTAIAATRTLDEDTCQTIAESCAQMTKSITSCSSEYTKGAELTSCRCQESIVALASVCIIDGPESCIGTSVASKDIWEYQNCAAATGVFETSTDKGPVTVTAGATTAGDAPPTTLTFGPGATAATTTSGSSCLKCSKTGRGALGAVLLMVAYASFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7YX50</accession>
    <name>C7YX50_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_82893</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049236.1">
        <property type="nucleotide sequence ID" value="XM_003049190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YX50"/>
    <dbReference type="GeneID" id="9666218"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82893"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82893"/>
    <dbReference type="eggNOG" id="ENOG502QQ29">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015161_3_0_1"/>
    <dbReference type="InParanoid" id="C7YX50"/>
    <dbReference type="OMA" id="REYWGPW"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="73"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU43523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="601" mass="67182" checksum="FF2009CFE0BE5226" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXS4</accession>
    <name>C7YXS4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_45251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049108.1">
        <property type="nucleotide sequence ID" value="XM_003049062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXS4"/>
    <dbReference type="STRING" id="660122.C7YXS4"/>
    <dbReference type="GeneID" id="9666405"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45251"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45251"/>
    <dbReference type="eggNOG" id="ENOG502RZSA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036110_1_2_1"/>
    <dbReference type="InParanoid" id="C7YXS4"/>
    <dbReference type="OMA" id="RVYAGCG"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052988">
        <property type="entry name" value="Oryzine_lactonohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064:SF2">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002986639" description="SMP-30/Gluconolactonase/LRE-like region domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="2">
        <location>
            <begin position="203"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU43395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="400" mass="42878" checksum="E7C5D81E311FBEC3" modified="2009-10-13" version="1">MSSSLAVVALGALVQSGLGLAAKVPSTAQVVDWKSFNVLENVLPPAEANDSTTFIWPGVTEKSLLEKPFHIYDDEFLDVIGSDPSLTLIATSDTDPIFHEAVVWHAPKDEVFFVQNAGAPAAGTGLNKSSIIQKISLKEAEAVRKGKLDEVAVTVVPSNPQVINPNGGTNYKGNIVFAGEGQGDDITSALYLMNPNAPYNTTVLLNNYFGRQFSSLNDVVIHPRNKELYFTDTLYGYLQDFRPPPGLRNQVYRYNFETGAVAVAADDFALPNGLTFSPDGKKAYVTDTGIALGFYGRNLSAPASVYSFDVSSDGTWGNRKTFAYTASFIPDGVHTDSAGRVYSGCGDGVHVWNPSGKLIGKIYTGAVAANFQFAGKGRMIITGQTKLFYVTLAASGVKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C7YY03</accession>
    <name>C7YY03_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CxC6 like cysteine cluster associated with KDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_82710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049138.1">
        <property type="nucleotide sequence ID" value="XM_003049092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YY03"/>
    <dbReference type="GeneID" id="9677030"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82710"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82710"/>
    <dbReference type="eggNOG" id="ENOG502RN5I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109888_0_0_1"/>
    <dbReference type="InParanoid" id="C7YY03"/>
    <dbReference type="OMA" id="CKFMELE"/>
    <dbReference type="OrthoDB" id="5099658at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU43425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24533" checksum="472B12B45DD22DCC" modified="2009-10-13" version="1">MCQFVELEFSCGESGGRHRKRTEAVWRCDTPVGCIINEMNKSIAETVVDVQDMDASSFKILYVGGHCDECAWRMGKEQVEKMILREDIETKLTKFKEHFEALCSKSSPTESLTQELVLEKTLLQRAVYDPKNICSSGPCTKPVISINSCRGLFCEEHTCAARKWGCLMDAVTKKNSPQSAMYCSAHTCEEFGCGMRVTQRDAIHCEKHRLSTVKGQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZ44</accession>
    <name>C7YZ44_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_46870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049014.1">
        <property type="nucleotide sequence ID" value="XM_003048968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZ44"/>
    <dbReference type="GeneID" id="9665675"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_46870"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_46870"/>
    <dbReference type="eggNOG" id="ENOG502SNKW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013866_2_1_1"/>
    <dbReference type="InParanoid" id="C7YZ44"/>
    <dbReference type="OMA" id="IWPLYTL"/>
    <dbReference type="OrthoDB" id="5429770at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DBAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="72"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU43301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="642" mass="69466" checksum="58985F4CBBDDADA6" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZJ9</accession>
    <name>C7YZJ9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">UBZ4-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_95752</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048527.1">
        <property type="nucleotide sequence ID" value="XM_003048481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZJ9"/>
    <dbReference type="FunCoup" id="C7YZJ9">
        <property type="interactions" value="844"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YZJ9"/>
    <dbReference type="GeneID" id="9667409"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95752"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95752"/>
    <dbReference type="eggNOG" id="KOG2028">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017985_0_1_1"/>
    <dbReference type="InParanoid" id="C7YZJ9"/>
    <dbReference type="OMA" id="RIILSQC"/>
    <dbReference type="OrthoDB" id="10265467at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:G-quadruplex DNA binding"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18139">
        <property type="entry name" value="HLD_clamp_RarA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3710.10:FF:000005">
        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000001">
        <property type="entry name" value="Putative AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000029">
        <property type="entry name" value="Replication-associated recombination protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000137">
        <property type="entry name" value="Replication-associated recombination protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3710.10">
        <property type="entry name" value="DNA polymerase III clamp loader subunits, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051314">
        <property type="entry name" value="AAA_ATPase_RarA/MGS1/WRNIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779:SF7">
        <property type="entry name" value="ATPASE WRNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779">
        <property type="entry name" value="WERNER HELICASE-INTERACTING PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBZ4-type" evidence="13">
        <location>
            <begin position="2"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="167"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="30"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU42814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="547" mass="59563" checksum="5A36EC06450AB180" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZM6</accession>
    <name>C7YZM6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U three protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_95767</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048347.1">
        <property type="nucleotide sequence ID" value="XM_003048301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZM6"/>
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        <property type="interactions" value="1055"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YZM6"/>
    <dbReference type="GeneID" id="9667616"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95767"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95767"/>
    <dbReference type="eggNOG" id="KOG1272">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022996_1_1_1"/>
    <dbReference type="InParanoid" id="C7YZM6"/>
    <dbReference type="OMA" id="EFLPYHW"/>
    <dbReference type="OrthoDB" id="10251154at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000378">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012952">
        <property type="entry name" value="BING4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040315">
        <property type="entry name" value="WDR46/Utp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085">
        <property type="entry name" value="WD-REPEAT PROTEIN BING4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08149">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01033">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="291"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="BING4 C-terminal" evidence="11">
        <location>
            <begin position="378"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="527"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="527"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU42634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="552" mass="63237" checksum="D4E1D7260D8C3A6E" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZN0</accession>
    <name>C7YZN0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Dicer-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">DCL2102</name>
        <name evidence="22" type="ORF">NECHADRAFT_95770</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048541.1">
        <property type="nucleotide sequence ID" value="XM_003048495.1"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YZN0"/>
    <dbReference type="GeneID" id="9667426"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95770"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95770"/>
    <dbReference type="eggNOG" id="KOG0701">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000907_4_6_1"/>
    <dbReference type="InParanoid" id="C7YZN0"/>
    <dbReference type="OMA" id="HFCAVIP"/>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050688">
        <property type="term" value="P:regulation of defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18034">
        <property type="entry name" value="DEXHc_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000032">
        <property type="entry name" value="Dicer-like protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-0930">Antiviral protein</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11 15" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="23"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="367"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="21">
        <location>
            <begin position="551"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="18">
        <location>
            <begin position="902"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="18">
        <location>
            <begin position="1092"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="17">
        <location>
            <begin position="1301"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="506"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EEU42828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="24">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1381" mass="157247" checksum="AFE35D8A884A5F38" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z068</accession>
    <name>C7Z068_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_101462</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048447.1">
        <property type="nucleotide sequence ID" value="XM_003048401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z068"/>
    <dbReference type="STRING" id="660122.C7Z068"/>
    <dbReference type="GeneID" id="9667524"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101462"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101462"/>
    <dbReference type="eggNOG" id="ENOG502QSWP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025694_1_2_1"/>
    <dbReference type="InParanoid" id="C7Z068"/>
    <dbReference type="OMA" id="CGFYWSG"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988405" description="Mannan endo-1,6-alpha-mannosidase" evidence="13">
        <location>
            <begin position="23"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="404"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU42734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="465" mass="51159" checksum="7FFBDAE7024BE0B2" modified="2009-10-13" version="1">MLSLKSAALVALSGGLFQAVDAQYKIGTKAEIKDTAAKLAYDLMLQYDGNTTGMIPGILPGPPTEFKGDYYWWEGGAMMGTYIDYWKLTGDSSYNHVIMEGMLHQTGDGHDYMPENHTASLGNDDQGFWGMSAMLAAENKFPNPPEDKAQWLALAQAVWTTQAHPNRHDKECNGGLRWQIPFTNAGYNYKNTIANGCFFNLGARLARYTGNSTYAKYAEETWDWLWDVQYIDHDDWRVYDGGHVEKNCTDINKATFSYNAAIMLQGAAFMYNYTNGSEVWETRVNNLTDSLLKNFFPKGIAWEVPCEGRKGACSTDMLSFKGYVHRWLSVVTQIVPHLKEKILPVLQTSTEAAVKQCTGGKSGRACGFYWSDGEFVDPAVDETSGAGEQMNVLAAVSSLLIGDAEPPVTNRTGGISKGDPDAGKESHDMPEPDPITQADKAGAGVLTFLILSSALGTFVWMCAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z097</accession>
    <name>C7Z097_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_95899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048463.1">
        <property type="nucleotide sequence ID" value="XM_003048417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z097"/>
    <dbReference type="GeneID" id="9667540"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95899"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95899"/>
    <dbReference type="eggNOG" id="ENOG502RZ1N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025462_2_1_1"/>
    <dbReference type="InParanoid" id="C7Z097"/>
    <dbReference type="OMA" id="NWTIQTH"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU42750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="343" mass="38810" checksum="8A6B9B74FCBE913E" modified="2009-10-13" version="1">MAAFDLASILPQLGLCLILATLLLALNRRLVKLVQPLNDFDWTVQQPQKFRPFKSIYHITMAIKSDTASELITIDRDYLDRIQLRKSLIQTQGQMVHGCVPAGVDAVDELYTYLVAQYLPKRYPTMFKLSADDSKLENLVTGDAHSTTPPVDHDTALRIMGTTVEEDLFILKPTPEGHQCVAFVCCFPSGWNPASKLGKHMGQIHFNVPSYNKIGPSMERFFTKLEVGKNVKRTNWTVQTHGELFNAKGNHVTGEEKVESEQIDPEKTYLRIELQTLSRLPRTHSILFSFKTYLYPLREIKEEGLGEEFATAIEGLEKGNAPGMWKYKGAVRWGASVCEYLRS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-24" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0Q8</accession>
    <name>RSSA_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small ribosomal subunit protein uS2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">40S ribosomal protein S0</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">RPS0</name>
        <name type="ORF">NECHADRAFT_68978</name>
    </gene>
    <organism>
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with RPS21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047956.1">
        <property type="nucleotide sequence ID" value="XM_003047910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0Q8"/>
    <dbReference type="SMR" id="C7Z0Q8"/>
    <dbReference type="FunCoup" id="C7Z0Q8">
        <property type="interactions" value="1278"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z0Q8"/>
    <dbReference type="EnsemblFungi" id="NechaT68978">
        <property type="protein sequence ID" value="NechaP68978"/>
        <property type="gene ID" value="NechaG68978"/>
    </dbReference>
    <dbReference type="GeneID" id="9667311"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_68978"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_68978"/>
    <dbReference type="eggNOG" id="KOG0830">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058171_0_1_1"/>
    <dbReference type="InParanoid" id="C7Z0Q8"/>
    <dbReference type="OMA" id="VKNFFEP"/>
    <dbReference type="OrthoDB" id="414863at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000010">
        <property type="entry name" value="40S ribosomal protein S0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03015">
        <property type="entry name" value="Ribosomal_S2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032281">
        <property type="entry name" value="Ribosomal_uS2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027498">
        <property type="entry name" value="Ribosomal_uS2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_uS2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16122">
        <property type="entry name" value="40S_SA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000389279" description="Small ribosomal subunit protein uS2">
        <location>
            <begin position="1"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="263"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="296" mass="31775" checksum="3A6A4EFF21CB8227" modified="2009-10-13" version="1">MAPSNLPSVFNATSQDIEMLLAAQCHLGSKNLQVHMENYLWKTRADGVNVLNVGKTWEKIVLAARIIAAIDNPADVCVISARPYGQRAVLKFASHTGATAIAGRFTPGSFTNYITRSFKEPRLIVVTDPRTDAQAIKEASYVNIPVIALTDTDSPTEYVDVAIPTNNKGRHAIGCVWWMLAREVLRLRGTIYSRETPWDVMVDLYFYRDPEAEAEEKVEEEKVPGAEEEGPAAIESGFAATGGDWEAPAAGFAGATGTGWDGAAGDEWGAAPATTEWAASAAPAAASGEAAKETTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1L0</accession>
    <name>C7Z1L0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cation efflux protein cytoplasmic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_50754</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU41841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047554.1">
        <property type="nucleotide sequence ID" value="XM_003047508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1L0"/>
    <dbReference type="GeneID" id="9671689"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_50754"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_50754"/>
    <dbReference type="eggNOG" id="KOG1485">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_2_2_1"/>
    <dbReference type="InParanoid" id="C7Z1L0"/>
    <dbReference type="OMA" id="CWALRNQ"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000003">
        <property type="entry name" value="Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF12">
        <property type="entry name" value="CATION DIFFUSION FACILITATOR 1 (AFU_ORTHOLOGUE AFUA_1G14440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="170"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="9">
        <location>
            <begin position="380"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU41841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="50428" checksum="DE25C860C60CE950" modified="2009-10-13" version="1">MSPDNSSTVIHHPHAIHLQSIDIARSSSRSSNNHHASSTAFEPVTADDNETIARNPSHMTDVESQVTATGRRHPSCLDPDPYGLSRAYKTDSDLDEIKANTSRKRGGAVGRKCIPDKVGSKVTARKLQGFYKNQNAAIERMLKSVEEHRDEARQEHGDDQLKFRIAVWGSFAANVVLSAVQLYAAISSGSLSLFTTMADSIFDPLSNLTLILSARAIRRVDPRRFPAGKARLETVGNIIFCFLMIAVSLIIIAFACQELVQEKDDKKFYLPSVVAVCCAFATKFALFLYCWALKDKYSQINILWQDHRNDLLINGFGILTSVGGAKLLWWIDPMGAILLSVLISGIWLGTAFGEFLLVVGVTGSVEMQQLITYVCVTHSDAIQGIDTVRVYHSGPRLIAEVDIVMDPTQTLQDSHDVAEALQFKLEDLPDIERAYVHIDYETTHKPEHKFKKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1L1</accession>
    <name>C7Z1L1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">glycogenin glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.186</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NECHADRAFT_123235</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Self-glucosylating initiator of glycogen synthesis. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-glucosyl-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23360"/>
            <dbReference type="Rhea" id="RHEA-COMP:14604"/>
            <dbReference type="Rhea" id="RHEA-COMP:14605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140573"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56560"/>
            <dbReference type="Rhea" id="RHEA-COMP:14606"/>
            <dbReference type="Rhea" id="RHEA-COMP:14607"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140574"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.186" evidence="10"/>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU41842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047555.1">
        <property type="nucleotide sequence ID" value="XM_003047509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1L1"/>
    <dbReference type="STRING" id="660122.C7Z1L1"/>
    <dbReference type="GeneID" id="9671690"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_123235"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_123235"/>
    <dbReference type="eggNOG" id="KOG1950">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017171_2_0_1"/>
    <dbReference type="InParanoid" id="C7Z1L1"/>
    <dbReference type="OMA" id="MVHFIGP"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008466">
        <property type="term" value="F:glycogenin glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000092">
        <property type="entry name" value="Glycogenin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="264"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="386"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="462"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="538"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="599"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="644"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="683"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="709"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="738"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU41842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="762" mass="84314" checksum="22660AA412DB0845" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1N2</accession>
    <name>C7Z1N2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_9477</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU42027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047740.1">
        <property type="nucleotide sequence ID" value="XM_003047694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1N2"/>
    <dbReference type="GeneID" id="9671705"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_9477"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_9477"/>
    <dbReference type="HOGENOM" id="CLU_000134_45_5_1"/>
    <dbReference type="InParanoid" id="C7Z1N2"/>
    <dbReference type="OMA" id="HWAARRQ"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF194">
        <property type="entry name" value="INVERSIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="7"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="40"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU42027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="73" mass="7794" checksum="0DAF82FA7B29D911" modified="2009-10-13" version="1" fragment="single">IDTFDSTGSTPLHLAARMNRTRDAEMLVAAGVDVDIKAYHGRTALMFAANCGDVDTVKVILKAGCNPNITEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z266</accession>
    <name>C7Z266_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_72550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU42118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047831.1">
        <property type="nucleotide sequence ID" value="XM_003047785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z266"/>
    <dbReference type="FunCoup" id="C7Z266">
        <property type="interactions" value="354"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z266"/>
    <dbReference type="GeneID" id="9671616"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_72550"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_72550"/>
    <dbReference type="eggNOG" id="KOG1505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041844_3_2_1"/>
    <dbReference type="InParanoid" id="C7Z266"/>
    <dbReference type="OMA" id="RMVMIAN"/>
    <dbReference type="OrthoDB" id="189226at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="6">
        <location>
            <begin position="138"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU42118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="415" mass="47961" checksum="556F7D0E777A2A0C" modified="2009-10-13" version="1">MADLKNADPSEASLPGPDLTAGLTEKPNVAPKVAHPSGREGYGTLMQILRGALFSFYFMTCCIIIHITQFIGAPLYFFNRDWYYAYMAMTKRSFCLTTTVMTQIWGPTTIRISGDESVAGQIKLRPDGGVQFEFPERLVLIANHQIYTDWLYLWWVGYANSPGMHGHIYIILKESLKMIPLIGWGMMFYGFIFMSRKMATDQPRLAYRLSKLKQRKVDPNGKSYMDPMWLLLFPEGTNLSRNGRRKSAGWAAKNDLKDPDHVMLPRSTGMFFCLNELKGTMDYVYDCTVAYEGIPRDGYGEELFGLSSTYFQGRPPKSVNFHWRRFRMADIPLDDQKEFDLWLREQWYQKDALMEQYMTTGRFPRMAGSKVDYIETEIKTRQPWEILQIFAVVGTAGLIWHNIKKTFVTATSMFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z286</accession>
    <name>C7Z286_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_86063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU41958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047671.1">
        <property type="nucleotide sequence ID" value="XM_003047625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z286"/>
    <dbReference type="GeneID" id="9671628"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86063"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86063"/>
    <dbReference type="eggNOG" id="ENOG502RNND">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_627062_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z286"/>
    <dbReference type="OMA" id="TETWESK"/>
    <dbReference type="OrthoDB" id="5097448at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002986736" description="Ig-like domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU41958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="40222" checksum="CC55A5383F1410FB" modified="2009-10-13" version="1">MGFTSLLIHLLAVGISTTVALEGPIVPARPTKTTLTVDCLWCTNTEVFDTSFTTSIEEHFSFPGFPPEVSKTTVCAQKCSVVTLSTVTWKSGMSKASPFTPSAVSTSCVTIYDDTPIPSLVTLSSMTASTSCSTSSEEMMISWEWVTPSSSSVWGIPPGERTWSLGTPIGTPMWSQASSFHFSQATDEASGSEPCTTELTVTMTKTITETWQSQTPMTTTLVRTRSTTIETIVVETYSTSTGERVVDGTRTETTTVQAVSSGKDCVQVGECPCSATVAPGESGTASILSVGSVSTDEEYVSSSEGSISWTSGSPSGSLVPNSTEDSVFETSETGWETGSEVSETDSEWSSGSETVVPTSIQTAGGAQVKAALGIGALLGLMGLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z317</accession>
    <name>C7Z317_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lysophospholipase</fullName>
            <ecNumber evidence="6">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_53807</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the lysophospholipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="6"/>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047293.1">
        <property type="nucleotide sequence ID" value="XM_003047247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z317"/>
    <dbReference type="STRING" id="660122.C7Z317"/>
    <dbReference type="GeneID" id="9676210"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_53807"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_53807"/>
    <dbReference type="eggNOG" id="KOG1325">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013227_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z317"/>
    <dbReference type="OMA" id="IRHERPW"/>
    <dbReference type="OrthoDB" id="6121437at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF40">
        <property type="entry name" value="PATATIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLA2c" evidence="7">
        <location>
            <begin position="118"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU41580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="723" mass="80965" checksum="E22C9C75944E6B9A" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z387</accession>
    <name>C7Z387_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TTL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_102179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047504.1">
        <property type="nucleotide sequence ID" value="XM_003047458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z387"/>
    <dbReference type="STRING" id="660122.C7Z387"/>
    <dbReference type="GeneID" id="9675936"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102179"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102179"/>
    <dbReference type="eggNOG" id="KOG2157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031301_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z387"/>
    <dbReference type="OMA" id="LARKDHM"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027746">
        <property type="entry name" value="TTL"/>
    </dbReference>
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        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU41791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="53471" checksum="69F25D9437CF8040" modified="2009-10-13" version="1">MHVYIQGANSWLNEHVEAYIRRHVPDAICYDNFASFPEDADTVFQLCDGWHMNRHFAALNKASNGLLNAYPNSDALARKDHLARVVDYWTTKRPDSILKGHVPATVRLSLDYSEYVDDALAAADDLTLLYSLEDNEQKDAAERDWWILKPAMIDCGHGIRIFSTIEELACNLELAANISEEEEEETDEDAESISTKPQGDDEPEFSPSLSIPGLSSLDALITATGKLSVDVTEQPRIKEPPLVIDEHERIPSAWMREFVAQQYIVSIPPLDGRKWHVRAYVLSIGRLKVHVFREMLALLALQDYEPPWKNPSLKSSLTNTALQDEDEFTSKESMREFWEISDDLLPGDWKNSIFNQACEISAELFRAAAHTMADKFTPLDKCFELFAIDFLIDSNGSAWLLEVNETPAFYQYGYAGALALRLMESLICVTMEHMGKAKLEDEKNAVAKERFIEVLDATNELAKSNITEIMPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z484</accession>
    <name>C7Z484_FUSV7</name>
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        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_101213</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047150.1">
        <property type="nucleotide sequence ID" value="XM_003047104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z484"/>
    <dbReference type="FunCoup" id="C7Z484">
        <property type="interactions" value="419"/>
    </dbReference>
    <dbReference type="GeneID" id="9675635"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101213"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101213"/>
    <dbReference type="eggNOG" id="ENOG502RZJP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027207_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z484"/>
    <dbReference type="OMA" id="RDRVEIM"/>
    <dbReference type="OrthoDB" id="5348546at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="117"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU41437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="537" mass="59033" checksum="2F8CF77A6D2ADE6C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4A3</accession>
    <name>C7Z4A3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_83535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046992.1">
        <property type="nucleotide sequence ID" value="XM_003046946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4A3"/>
    <dbReference type="STRING" id="660122.C7Z4A3"/>
    <dbReference type="GeneID" id="9675645"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83535"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83535"/>
    <dbReference type="eggNOG" id="ENOG502SQPH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_509088_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z4A3"/>
    <dbReference type="OMA" id="MARHTVP"/>
    <dbReference type="OrthoDB" id="5426775at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU41279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="535" mass="59607" checksum="E0517202F2EA171C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6K6</accession>
    <name>C7Z6K6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="2 11">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NECHADRAFT_76134</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 11">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="2 11"/>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045861.1">
        <property type="nucleotide sequence ID" value="XM_003045815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6K6"/>
    <dbReference type="FunCoup" id="C7Z6K6">
        <property type="interactions" value="621"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z6K6"/>
    <dbReference type="GeneID" id="9668695"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76134"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76134"/>
    <dbReference type="eggNOG" id="KOG2711">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033449_2_3_1"/>
    <dbReference type="InParanoid" id="C7Z6K6"/>
    <dbReference type="OMA" id="NRMFGNM"/>
    <dbReference type="OrthoDB" id="10263760at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000004">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000294">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF8">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0520">NAD</keyword>
    <keyword evidence="3 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="13">
        <location>
            <begin position="12"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="14">
        <location>
            <begin position="264"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="17"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="341"/>
            <end position="342"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU40148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="417" mass="45442" checksum="6D7C65BF6C50E804" modified="2009-10-13" version="1">MTNLGGHSKKHKVTIVGSGNWGSTIAKIVAENTRANKDVFEEEVQMWVYEEDVTISKDSKYYDETIGDKPQKLTEVINKHHENVKYLPGIALPPNIVANPDIRAAVKDSTILVFNLPHQFIANVCKQINGHILPFARGISCIKGVNVTDDGVSLFSEWIGDGLGIYCGALSGANLAREIAEEKWSETTIAYDPPALDNSRAPSPRDGSPNPTIGELPEIRHKDVRGRTSKTKLTAMPADYPPLDQDCFRTLFHRHYFHVQMVSDVAGVSLSGALKNVVALAAGFVDGRGWGDNAKAAIMRVGLMEMVKFGKEFFGETVHTATFTESSAGVADLITSCSGGRNFRCAKKSVEKGISVQEVEQQELNGQKIQGTTTAEEVNSFLKARGLESEYPLFTAVHAILNGQAKVDDIPNLVQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7E3</accession>
    <name>C7Z7E3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Mitochondrial import inner membrane translocase subunit Tim21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_103421</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the TIM21 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045999.1">
        <property type="nucleotide sequence ID" value="XM_003045953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7E3"/>
    <dbReference type="FunCoup" id="C7Z7E3">
        <property type="interactions" value="243"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z7E3"/>
    <dbReference type="GeneID" id="9668357"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_103421"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_103421"/>
    <dbReference type="eggNOG" id="KOG4836">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089407_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z7E3"/>
    <dbReference type="OMA" id="HFHVEGP"/>
    <dbReference type="OrthoDB" id="436405at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.320:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.320">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit Tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013261">
        <property type="entry name" value="Tim21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038552">
        <property type="entry name" value="Tim21_IMS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032:SF6">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08294">
        <property type="entry name" value="TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="12" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU40286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="231" mass="25946" checksum="F7C60597AFDDF716" modified="2009-10-13" version="1">MKPTTSLIPIRSTIFVGCPSKLQPLLLSRCYATHKGVGATPQGPKRRAVTPFNDTGYVPWSQLSVAEKAGRATQQTVNFGMILIGLVLTGGVTYFMWTEVFSPDSKISNFNRAVDRIKDDPRCLELLGDAKKISAHGDETFNKWRRARPVASTESVDAQGNQHLLMHFYVEGPLNNGVARLHMIRHRGQGDYEYKYFFVDVRGHERVYLEHEETAASKLGKKLSFFGVKWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7Q0</accession>
    <name>C7Z7Q0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_100265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045440.1">
        <property type="nucleotide sequence ID" value="XM_003045394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7Q0"/>
    <dbReference type="GeneID" id="9672480"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100265"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100265"/>
    <dbReference type="eggNOG" id="ENOG502RJ0A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164879_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z7Q0"/>
    <dbReference type="OMA" id="NNDAHPQ"/>
    <dbReference type="OrthoDB" id="4467949at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU39727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="114" mass="13542" checksum="F36A1F8B2B28E548" modified="2009-10-13" version="1">MTFRNLNETWRDVVFRTYAQDHQDDVPFPIKYLIHAPEWKRDILIEVPKKIDVKAYRHSVLKCTIDLRFQDPVYDDEYISVRPRVRKYNIDKGREKALEGEASQGDASVERSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7W7</accession>
    <name>C7Z7W7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10 13">Catalase</fullName>
            <ecNumber evidence="3 10 13">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">NECHADRAFT_60561</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 13">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10 13"/>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045611.1">
        <property type="nucleotide sequence ID" value="XM_003045565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7W7"/>
    <dbReference type="STRING" id="660122.C7Z7W7"/>
    <dbReference type="PeroxiBase" id="8419">
        <property type="entry name" value="NhaeKat01"/>
    </dbReference>
    <dbReference type="GeneID" id="9667898"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_60561"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_60561"/>
    <dbReference type="eggNOG" id="KOG0047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010645_3_0_1"/>
    <dbReference type="InParanoid" id="C7Z7W7"/>
    <dbReference type="OMA" id="WQMSDRA"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000003">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821:SF1">
        <property type="entry name" value="CATALASE-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18011">
        <property type="entry name" value="Catalase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 13" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="15">
        <location>
            <begin position="38"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEU39898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="738" mass="82904" checksum="3D5674A4E444076C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7W8</accession>
    <name>C7Z7W8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_79584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045476.1">
        <property type="nucleotide sequence ID" value="XM_003045430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7W8"/>
    <dbReference type="ESTHER" id="nech7-c7z7w8">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="9672512"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79584"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79584"/>
    <dbReference type="eggNOG" id="ENOG502QS8H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_49_0_1"/>
    <dbReference type="InParanoid" id="C7Z7W8"/>
    <dbReference type="OMA" id="YLPWHAR"/>
    <dbReference type="OrthoDB" id="294702at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45763:SF46">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45763">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="32"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="319" mass="35197" checksum="EB22042535DABB06" modified="2009-10-13" version="1">MGASPRTLLIFRLPSTKRLISWAEFGSPNGRPIIYLHGTPSSRLECAGFHQELHDRNIRLIAPDRPGFGRSEVQPGRTIGGYASDVRALAKQLNLSGYAVMGQSGGGPYALACARYIRPEDGLRAVAVLGGLSPFESEFEGAHWATSFSLKMAKWAPGLLGFFLRLPIPSRKGNFTGPLEEWTVDPSMLAEAEKTQQAFVNTMKGREKEVMSEPGVVHHLTTTFVEATIQGVDAHLYESKLFAQGWDFKLQDITFASEGKRPLIMWYGAKDVNTTVHMGKWIAERVAGSQLREVDGETHNTLVVKFVDYCDELLKVSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9N8</accession>
    <name>C7Z9N8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FMP27 GFWDK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_70370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045246.1">
        <property type="nucleotide sequence ID" value="XM_003045200.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="C7Z9N8">
        <property type="interactions" value="473"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z9N8"/>
    <dbReference type="GeneID" id="9673832"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_70370"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_70370"/>
    <dbReference type="eggNOG" id="KOG1910">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000592_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z9N8"/>
    <dbReference type="OMA" id="IQLKWNN"/>
    <dbReference type="OrthoDB" id="1562405at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019441">
        <property type="entry name" value="FMP27/BLTP2/Hobbit_GFWDK_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019415">
        <property type="entry name" value="FMP27_SW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019449">
        <property type="entry name" value="FMP27_WPPW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045167">
        <property type="entry name" value="Hobbit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678">
        <property type="entry name" value="ANTIGEN MLAA-22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678:SF6">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10344">
        <property type="entry name" value="Hobbit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01214">
        <property type="entry name" value="Fmp27_GFWDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01215">
        <property type="entry name" value="Fmp27_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01216">
        <property type="entry name" value="Fmp27_WPPW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMP27 SW motif-containing RBG unit" evidence="3">
        <location>
            <begin position="1145"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27/BLTP2/Hobbit GFWDK motif-containing RBG unit" evidence="2">
        <location>
            <begin position="1265"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27 WPPW motif-containing RBG unit" evidence="4">
        <location>
            <begin position="1671"/>
            <end position="2190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="830"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1076"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1911"/>
            <end position="1930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2005"/>
            <end position="2040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2529"/>
            <end position="2677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2785"/>
            <end position="2924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2943"/>
            <end position="3049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="718"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2560"/>
            <end position="2571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2645"/>
            <end position="2659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2667"/>
            <end position="2677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2838"/>
            <end position="2853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2908"/>
            <end position="2924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2964"/>
            <end position="2973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU39533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3049" mass="344231" checksum="801BBE42DBFA72C3" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9S6</accession>
    <name>C7Z9S6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_22286</name>
    </gene>
    <organism evidence="4 5">
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        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045266.1">
        <property type="nucleotide sequence ID" value="XM_003045220.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9S6"/>
    <dbReference type="GeneID" id="9672221"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_22286"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_22286"/>
    <dbReference type="eggNOG" id="ENOG502QQIE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012066_2_0_1"/>
    <dbReference type="InParanoid" id="C7Z9S6"/>
    <dbReference type="OMA" id="GYDWEPS"/>
    <dbReference type="OrthoDB" id="415532at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025340">
        <property type="entry name" value="DUF4246"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049192">
        <property type="entry name" value="DUF4246_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049207">
        <property type="entry name" value="DUF4246_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119">
        <property type="entry name" value="IFI3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14033">
        <property type="entry name" value="DUF4246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21666">
        <property type="entry name" value="DUF4246_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4246" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4246" evidence="2">
        <location>
            <begin position="54"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU39553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="571" mass="65934" checksum="62146BABD150035B" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZA33</accession>
    <name>C7ZA33_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">UEV domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_62245</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044916.1">
        <property type="nucleotide sequence ID" value="XM_003044870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZA33"/>
    <dbReference type="FunCoup" id="C7ZA33">
        <property type="interactions" value="574"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZA33"/>
    <dbReference type="GeneID" id="9672277"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_62245"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_62245"/>
    <dbReference type="eggNOG" id="KOG2391">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017548_2_1_1"/>
    <dbReference type="InParanoid" id="C7ZA33"/>
    <dbReference type="OMA" id="YMNFPQP"/>
    <dbReference type="OrthoDB" id="306304at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072666">
        <property type="term" value="P:establishment of protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052070">
        <property type="entry name" value="ESCRT-I_UEV_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017916">
        <property type="entry name" value="SB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008883">
        <property type="entry name" value="UEV_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306:SF3">
        <property type="entry name" value="TUMOR SUPPRESSOR PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306">
        <property type="entry name" value="TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05743">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09454">
        <property type="entry name" value="Vps23_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51312">
        <property type="entry name" value="SB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51322">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UEV" evidence="10">
        <location>
            <begin position="6"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="SB" evidence="9">
        <location>
            <begin position="450"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="148"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="289"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU39203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="56691" checksum="4ECEF2ABC4EC7CD8" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZA51</accession>
    <name>C7ZA51_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_43561</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044927.1">
        <property type="nucleotide sequence ID" value="XM_003044881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZA51"/>
    <dbReference type="STRING" id="660122.C7ZA51"/>
    <dbReference type="GeneID" id="9672284"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_43561"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_43561"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="InParanoid" id="C7ZA51"/>
    <dbReference type="OMA" id="WSTENYW"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF190">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU39214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="55412" checksum="8D90FB137F70B6F2" modified="2009-10-13" version="1">MESSISIYVLSVLFIAFLVRFLVQFIRSPLRTVPGPFLARFTDGWYFWNVRKGSFQDVNVELHKKYGTIVRYGPNRYSFNDPEAAKIIYGLGNHFPKSSWYSSWASPGQWAIFSDQSIKRHAQNRRLYQATYAMSSLVHYEPFVDECSDLFTQRLAEMSRSNMLVDMRHWFQCYAFDVIGLITYAKRLGFLDRGDDIRGVISALEEHLGYATLVGIFPSLHRYLFPLKNYLAGAKGAGRAYVLSFTNERIREAQVTPKPVAEESAVTMEDFLTKFLAKHAADPDVFTSFHVLAGCTSNMVAGSDTTAISLSAVLYYLLKHPACLQKLRDEIDGLTAKGGLSKSPTFKESQQLPYLQAVIKEAQRDDLTTVGINTWVAHRDHRVFGDDAETFNPDRWLVDDAARLSIMNRYYMPFGLGSRTCIGRHVSMLEMSKLIPRIVRDFDFGLDPSLQREKWHTQNYWFVKPLDFKVRVEMRQAEKSDMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZA92</accession>
    <name>C7ZA92_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_82017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044947.1">
        <property type="nucleotide sequence ID" value="XM_003044901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZA92"/>
    <dbReference type="GeneID" id="9672129"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82017"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82017"/>
    <dbReference type="eggNOG" id="ENOG502S51T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024934_0_4_1"/>
    <dbReference type="InParanoid" id="C7ZA92"/>
    <dbReference type="OMA" id="IHYLRFR"/>
    <dbReference type="OrthoDB" id="3546279at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU39234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="43706" checksum="978743507F69296E" modified="2009-10-13" version="1">MVESENLPTQPLSVQTIPSRPRKRIGFRKSRNGCLRCKTRKVKTCVPSQSPLGDDGPLASTTGTPLVPFPFLSVDPADAPECWLSNAELIFHYTNVTCRSILSGHAMPTYQVVIPQEGLSHPYLMRMIMALSSFHLAYLNKDKRPHYLALANKQQSLAVRGLRGTLGQAVTQQNCHALWVSSIFLAISKFAFSPSCDHRQDGCCSALLNLVDIFSMINGMMAIMRSSLHLIQTGPLKAIFNKRQGFRYARENLQELLQRLSDLDGVLKSMELDLDPSVHLALTSALERLISCVTDIIKPPDSGSCSMDIKILFIWPSEVSQGFFDLVRARHPLAVIILAHYCCLIRWSASAYWFCRCWGRPLADSVLSILEDSDLAHWAEWSVKVMREDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAH0</accession>
    <name>C7ZAH0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_82095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045389.1">
        <property type="nucleotide sequence ID" value="XM_003045343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAH0"/>
    <dbReference type="STRING" id="660122.C7ZAH0"/>
    <dbReference type="ESTHER" id="nech7-c7zah0">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="9672344"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82095"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82095"/>
    <dbReference type="eggNOG" id="KOG4389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_14_0_1"/>
    <dbReference type="InParanoid" id="C7ZAH0"/>
    <dbReference type="OMA" id="KMYQVVA"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="7"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU39676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="506" mass="56467" checksum="BDC6A9C90C9A4637" modified="2009-10-13" version="1">MTDSFVTLQTSSSTVQGIQDERFERHVWHFRGIPYGRIPERFHKPAYDALPRELDATKFGPQCPQPKVDVGHLLRLPRNLESPTIEEDEFNCLNLNISRPTSADIKDKGLLPVLVWIHAPGGSQCVTFASAASPVCDPTRFVAESVDSDRPIIIVTFNYRLNIFAFGDGEGERNLALQDQRLALQWVSDNIRDFGGDPGKITLAGESAGAVYVHAHVLSKTAPKCVSQAILASGSLHLSPPQPLEVGQGLLKRITTELQARGETLHNSSADSLVQALINCGVTSMWLQEDPDIDGWENRTEEIDGIMVSDVEYESAIWRSGVDLLKPEEILEIIRSCSQDAPKLEELYHIYSERPVSSRLGVLDIINDTRFALPALEISERWRKINKKVYQYIVDEANPWQASSRAHHAVDLIFLFGGVDLSFNPGADRVGKEMRQAWMTFMYGGSPWPESSIQGYGPYGNVEELDMQKYKARRRVHCFDHLQTMGAAQCRLLSGRLGAGRVSLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAY3</accession>
    <name>C7ZAY3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_45720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044386.1">
        <property type="nucleotide sequence ID" value="XM_003044340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAY3"/>
    <dbReference type="GeneID" id="9670808"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45720"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45720"/>
    <dbReference type="eggNOG" id="ENOG502QSKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZAY3"/>
    <dbReference type="OMA" id="WTWNEDS"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU38673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="43404" checksum="E2C026F29C7871AC" modified="2009-10-13" version="1">MSDKNEAKKPRNATQGTVEAPASPGSPPLAAQAVSTEASHGSGILPPQHWQQAAIVSTNHHLTFASWLSNFNGTTNADSALEDNISSTASIASSILKYRTILGRTFHSEQGDAHYWGANDERQNEAMDINHHCQTIRLDGKVFLAPLSNDIKASIPFVLDNSSQCSDFADQFPGCEVIGTDISPIQPSWTPPNLQFQIDDCTKEWTFPEASLDYVHVRFLTGCIADWEALIKAAYRCLKPDSYIQSMEPSAYIQSDDNTIEPDSAMGQWGKIFVEGGNKMGRPFTVVEDELQNKALEKAGFVDIQEKKHKSPIGSWPKDEKLREIGQYAQLSMEQDFEGLILFMTNVLGGWSREDIQVYTTHLRREIRSGKKHGWYWQKVVWARKPVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZB08</accession>
    <name>C7ZB08_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phenylacetyl-CoA ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_45761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044422.1">
        <property type="nucleotide sequence ID" value="XM_003044376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZB08"/>
    <dbReference type="STRING" id="660122.C7ZB08"/>
    <dbReference type="GeneID" id="9672725"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45761"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45761"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="InParanoid" id="C7ZB08"/>
    <dbReference type="OMA" id="PEFWIAG"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="78"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="475"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU38709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="577" mass="63971" checksum="762CB2308A634618" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBN8</accession>
    <name>C7ZBN8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="2">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_55169</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="2"/>
    <dbReference type="EMBL" id="GG698915">
        <property type="protein sequence ID" value="EEU38547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044260.1">
        <property type="nucleotide sequence ID" value="XM_003044214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBN8"/>
    <dbReference type="GeneID" id="9670635"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55169"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55169"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010365_8_1_1"/>
    <dbReference type="InParanoid" id="C7ZBN8"/>
    <dbReference type="OMA" id="KQDTMEL"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF26">
        <property type="entry name" value="FAD-BINDING 8 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="7">
        <location>
            <begin position="260"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU38547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="425" mass="48173" checksum="07D7C6EEE84D6BB0" modified="2009-10-13" version="1">MKLDFSITDWYAFGLAIILSLLALRRAIATVFRFICPLAFQIWNFQAFYRIRKRVSQWSVKHLVYRSFFRHGSSLDTFTRAHTILFLSYLVSNLGYVLINTLDTAEAFSRAGVLAVINAVLLYVGPCLDFVATVLHLRLRIQKQIHATAGYMVAVLCTIHAAGIFSRYGWSAMDETHNLLAALVVALLGVYLMLIPMKALPAVFPYEFLLFTHHSMSVMIGYAIWRHIPADNHRIRVFLYGIAGIFLSSLALQTLVTLYRNHFWFQSVSLSKNGSFDYIQVKLTLRKPVKVEPGQYINLWIPLGPISSIQSHPFTVANWSPDAQKELKLFVEVNNGLTKTLRGRVELGLTSNIGIFTGPYGSRITVENYETIILIATGLGVVALTPYLQWLVHAARMREVRIAPVHLVWQIPSWSRLFSFSLCIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBV3</accession>
    <name>C7ZBV3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_88559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698916">
        <property type="protein sequence ID" value="EEU38476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044189.1">
        <property type="nucleotide sequence ID" value="XM_003044143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBV3"/>
    <dbReference type="GeneID" id="9670577"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88559"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88559"/>
    <dbReference type="eggNOG" id="ENOG502RVMB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1877023_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZBV3"/>
    <dbReference type="OMA" id="AVSDWIF"/>
    <dbReference type="OrthoDB" id="2332199at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU38476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="161" mass="17103" checksum="085E89C054C2D4C9" modified="2009-10-13" version="1">MLHVKSADCVGWMIFWNGNNLKVSNVFVVINSVAQLYYVSRRLPPMDTSSANSILTHIVSKTFAGIGVLDLLHNFSAAYFVSTQPSAAVKVAIGVGFGLLSAASDWIFGGCLVYDLVALAVGQSVYGNVGWSRLLGIYAGGAAAIVGMKNFSGSRWGYESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZD34</accession>
    <name>C7ZD34_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_48313</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698919">
        <property type="protein sequence ID" value="EEU38151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043864.1">
        <property type="nucleotide sequence ID" value="XM_003043818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZD34"/>
    <dbReference type="STRING" id="660122.C7ZD34"/>
    <dbReference type="GeneID" id="9670226"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_48313"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_48313"/>
    <dbReference type="eggNOG" id="ENOG502RZ21">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_18_0_1"/>
    <dbReference type="InParanoid" id="C7ZD34"/>
    <dbReference type="OMA" id="QFFFVYF"/>
    <dbReference type="OrthoDB" id="9975416at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050832">
        <property type="entry name" value="Bact_Acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43877">
        <property type="entry name" value="AMINOALKYLPHOSPHONATE N-ACETYLTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="16"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU38151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="186" mass="20622" checksum="8625C1868B1E587A" modified="2009-10-13" version="1">MAVKESQPIAATNKPVTIRPASVKDAGRVAELGAHVFTITFGHSVEPHELEAFLEESYTPSAITKDINDHDKDVIVATDANNDILGFAYLTRGTTEPCVQHVEKTVELQRIYVHPLAHGKGVGRALERATETMAREQGFKNIWLGVWEENPRAIKAYEKWGYTQVGDHDFVIGTVVQTDNIMLKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEG4</accession>
    <name>C7ZEG4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_87485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698921">
        <property type="protein sequence ID" value="EEU37591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043304.1">
        <property type="nucleotide sequence ID" value="XM_003043258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEG4"/>
    <dbReference type="GeneID" id="9669291"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87485"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87485"/>
    <dbReference type="eggNOG" id="ENOG502SEJU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059589_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZEG4"/>
    <dbReference type="OMA" id="VSNPLCE"/>
    <dbReference type="OrthoDB" id="3204049at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU37591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="324" mass="35801" checksum="A73AE83BFCD66F72" modified="2009-10-13" version="1">MHLDHKIPWKTAASHFNLVPSNTEGRFDVVALDLPSQASTLGHFSRVVSATIKEFSETELTKVPSAPSSAKLFSDDVLVFPERHFGLGPHDTNSALHNPLSTSHQDVKYWQRRAEGGDFCTSDGDLADAVKMLVVIAAVAPKKPLRIEALAALLRLASETPLSQLRSLSWGHAFGANLVASVALQAYVLLNLTEAVQCRQKEHISLLKIDPLMGVLNRDALQDYDYPAQNIPHRAFWSSIGVLDLSRGAGGDECVVVDPLAQENDEIHQEARSGLRQYLKDCFAILYVYDVVLRQACGSNEAEEFWAYEMGGVFWRLGCKMKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEJ1</accession>
    <name>C7ZEJ1_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_106525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698921">
        <property type="protein sequence ID" value="EEU37705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043418.1">
        <property type="nucleotide sequence ID" value="XM_003043372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEJ1"/>
    <dbReference type="GeneID" id="9669303"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_106525"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_106525"/>
    <dbReference type="HOGENOM" id="CLU_1540468_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZEJ1"/>
    <dbReference type="OrthoDB" id="5088079at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988772" evidence="2">
        <location>
            <begin position="20"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU37705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="174" mass="18083" checksum="5BC486A029B260A3" modified="2009-10-13" version="1">MKVTAAVTILAFAANTVMAVPVAPREEAGIFDAVKTGLDAAGNIFGTGIGSAASLFGMAFDGAICTIDSFFGGRRPTCGGRATLGNNGKITATTTTTKGDTKGDTKGNTNTNTNTNVNQESNDDSFSFKYSTEEDGRLKVTIIPDAKGKSQCVTIVKKEGEIKDIIAREADKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEK3</accession>
    <name>C7ZEK3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_53466</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698921">
        <property type="protein sequence ID" value="EEU37711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043424.1">
        <property type="nucleotide sequence ID" value="XM_003043378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEK3"/>
    <dbReference type="STRING" id="660122.C7ZEK3"/>
    <dbReference type="GeneID" id="9669309"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_53466"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_53466"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_3_1"/>
    <dbReference type="InParanoid" id="C7ZEK3"/>
    <dbReference type="OMA" id="MVPEREI"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF33">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU37711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="474" mass="50458" checksum="42D12FA90379C0F2" modified="2009-10-13" version="1">MLIIKGTFLGSSDNSLVMATHPTIASEFDALGMSSWLLTAFSLGGATTQITVSKLGEVFGRKQVVLTAHVAFALGCGVGQSMWHVILARLLSGSAGAGLGVLTSLVITDLVPLREVAVWRSYVNVAGTLGRSVGAPLGGWLADAVSWRWSFIGQGPLVLLAALCVWISFPGQLSQAEPRQTSLALSTRIARIDWAGAFTLAVTIASLLLPLEIGGVNVPWSHPLILCLFAGHHVLLAGFIYIETRLVREPIIDLSIFRDKHVLGCFGIMFLQISAQIGLMFSVPLYFKVTAGASNAEAGARLFPAAFGNTVAGIMAGIFIKRTGNHRALLITGTLLSIFGYLLIILRWRGNTGWLGSLYILLSGFGTGFVQSAVFISLQSAVEKTKLTAAISCLYLSVALASTQGLAMINAVLQIAVRRNLGRRLADIGLDTVQRDKIIADALDDVGYIRDAPAQIAKAITTSYIHALESTHCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFT0</accession>
    <name>C7ZFT0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_86664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698924">
        <property type="protein sequence ID" value="EEU37089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042802.1">
        <property type="nucleotide sequence ID" value="XM_003042756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFT0"/>
    <dbReference type="STRING" id="660122.C7ZFT0"/>
    <dbReference type="GeneID" id="9664830"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86664"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86664"/>
    <dbReference type="eggNOG" id="ENOG502R122">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058270_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZFT0"/>
    <dbReference type="OMA" id="KCCKLHQ"/>
    <dbReference type="OrthoDB" id="3766406at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU37089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="41342" checksum="BD74D5E5279FD431" modified="2009-10-13" version="1">MDMSCIEIKDHCCRCQRVAAWPGVTMKRVASHAKRIICRLRPSPGQNLDCRLLQLPVDIFVAVIDHLSEVDRHVLAKTCRAFWTDIRRRYEPISSLSKNQYLRYLINISRSNPDVWVCELCAKLHPARNQTCPRHARKSYYLAGSSVKLSLQHRHVQLALKLDRLGNLNKRQRKLLDQLTMSHRATLSTCSTIRGAVRCRYDAYPKIIQGRYMALSVWTYEQWSEPISQQVIELFSICRHQGLTFTMAFTEMSFWDYEKENLETGGRPSKVRHALRFAFELARQRPGTAVDGSCASCPVDFSVNFSPEKMIIRAWHDFGPEGSPLDPAWMVHARHPLCSPNEALTLDHVEGSVRELYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZG46</accession>
    <name>C7ZG46_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Antigenic cell wall galactomannoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_106471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698924">
        <property type="protein sequence ID" value="EEU37015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042728.1">
        <property type="nucleotide sequence ID" value="XM_003042682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZG46"/>
    <dbReference type="GeneID" id="9664932"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_106471"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_106471"/>
    <dbReference type="eggNOG" id="ENOG502SR1T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091392_0_1_1"/>
    <dbReference type="InParanoid" id="C7ZG46"/>
    <dbReference type="OMA" id="DINQGTR"/>
    <dbReference type="OrthoDB" id="2422134at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021054">
        <property type="entry name" value="Cell_wall_mannoprotein_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123:SF4">
        <property type="entry name" value="CELL WALL GALACTOMANNOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123">
        <property type="entry name" value="CELL WALL SERINE-THREONINE-RICH GALACTOMANNOPROTEIN MP1 (AFU_ORTHOLOGUE AFUA_4G03240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12296">
        <property type="entry name" value="HsbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988082" description="Antigenic cell wall galactomannoprotein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="18372" checksum="6C79C53ACAAFD7C6" modified="2009-10-13" version="1">MRLSILPVLALAGSALASGATIIAAINDIGNATLSLNKTIADWPKTLIGTLPIITKSTILLAEIHNGTKTARASRELSVDETIAVAQATTKLGGQVNMTLETVIRAKPDFDRLLLRPVILLNLELQRDLTEDFSDAVIAKVPDELQANAKELVKGIGESFEKAIKTYSSLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZGB4</accession>
    <name>C7ZGB4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_42279</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698925">
        <property type="protein sequence ID" value="EEU36886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042599.1">
        <property type="nucleotide sequence ID" value="XM_003042553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZGB4"/>
    <dbReference type="STRING" id="660122.C7ZGB4"/>
    <dbReference type="GeneID" id="9670099"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_42279"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_42279"/>
    <dbReference type="eggNOG" id="ENOG502RZKF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055491_3_0_1"/>
    <dbReference type="InParanoid" id="C7ZGB4"/>
    <dbReference type="OMA" id="CNCFDCR"/>
    <dbReference type="OrthoDB" id="428768at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF8">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="26"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU36886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="181" mass="20074" checksum="9A6BACFED7FDB16E" modified="2009-10-13" version="1">MADKSDKPTASFPLAGLADDGWFKDDEATVTCFCGAVQIAFPTSGPGFVNTFVCHCTDCRKVTASMFASNFTVKNDAINFIRGRETLKSFGQAKTVGTHNTMTNYFCSTCGTLMWRESSGFPNVKFMRIGTVDDFHLHETKLRPQVEQFVESRVGWLEPIEGVKQVHGQSTGKRNKIRVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZH05</accession>
    <name>C7ZH05_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_86555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698927">
        <property type="protein sequence ID" value="EEU36727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042440.1">
        <property type="nucleotide sequence ID" value="XM_003042394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZH05"/>
    <dbReference type="STRING" id="660122.C7ZH05"/>
    <dbReference type="GeneID" id="9669680"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86555"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86555"/>
    <dbReference type="eggNOG" id="ENOG502SS8J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002639_9_0_1"/>
    <dbReference type="InParanoid" id="C7ZH05"/>
    <dbReference type="OMA" id="WTISEHS"/>
    <dbReference type="OrthoDB" id="2958217at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="227"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU36727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="736" mass="83053" checksum="08834EE6C4CA1FAF" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZH22</accession>
    <name>C7ZH22_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_51989</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698927">
        <property type="protein sequence ID" value="EEU36736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042449.1">
        <property type="nucleotide sequence ID" value="XM_003042403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZH22"/>
    <dbReference type="GeneID" id="9669524"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51989"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51989"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_0_1"/>
    <dbReference type="InParanoid" id="C7ZH22"/>
    <dbReference type="OMA" id="WKREGWR"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF12">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="487"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="68"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU36736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="549" mass="59791" checksum="4D83E7AB0B9DC0AD" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZH29</accession>
    <name>C7ZH29_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_51927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698927">
        <property type="protein sequence ID" value="EEU36648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042361.1">
        <property type="nucleotide sequence ID" value="XM_003042315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZH29"/>
    <dbReference type="GeneID" id="9669527"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51927"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51927"/>
    <dbReference type="eggNOG" id="ENOG502SPBH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_9_3_1"/>
    <dbReference type="InParanoid" id="C7ZH29"/>
    <dbReference type="OMA" id="HAWVQRC"/>
    <dbReference type="OrthoDB" id="184880at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF110">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU36648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="30498" checksum="6E5C5496040F5F3E" modified="2009-10-13" version="1">MSTEADPQYLLKESNREVERLQKQHAWFQRCLNNQIVFAPVNLNKQGLRVLDVGCADGILLRDLQKQVAPSAQLVGVDIMNSFMPSSPQGNISYEVYDVCEPPSGELEGAFDFTHVRYVLPGCAKVGYEQAVSNLAATLAPGGWLQVQEMDLDYNRSEVGQATNDANQVFSGIFDKIGLGARFPSKLDKAFEAAGLVNVSIQNVDLPMGKRLGDDKAAQDSWEPFAITIPSVVETAKSLGADIPNSVYDNLAERFEKEVKEQGSLWRSFIIIGKKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHI3</accession>
    <name>C7ZHI3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_81254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698928">
        <property type="protein sequence ID" value="EEU36548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042261.1">
        <property type="nucleotide sequence ID" value="XM_003042215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHI3"/>
    <dbReference type="GeneID" id="9669217"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_81254"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_81254"/>
    <dbReference type="HOGENOM" id="CLU_1563277_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZHI3"/>
    <dbReference type="OrthoDB" id="10326256at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU36548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="171" mass="19280" checksum="71E53CB7329A1860" modified="2009-10-13" version="1">MPMHGWHVKSRNGERLTASRLIPTNANAARPGLALGAMRWRPPWRCRPAGMSPGIDPFSPPLPTPFQGVEADERALIPLMPECLTKEPVSNLPQAASLGRRSYTLAEARRSLQTLLRTVRRIHFKLPAFDDGYYSAVLNSPAKQIDEVQAARQTRDRFIQFMHELILSSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZIE7</accession>
    <name>C7ZIE7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBM21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_106502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698930">
        <property type="protein sequence ID" value="EEU36249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041962.1">
        <property type="nucleotide sequence ID" value="XM_003041916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZIE7"/>
    <dbReference type="STRING" id="660122.C7ZIE7"/>
    <dbReference type="GeneID" id="9674318"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_106502"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_106502"/>
    <dbReference type="eggNOG" id="KOG3986">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048912_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZIE7"/>
    <dbReference type="OrthoDB" id="1881at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF36">
        <property type="entry name" value="GLYCOGEN-BINDING SUBUNIT 76A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM21" evidence="2">
        <location>
            <begin position="259"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU36249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="390" mass="43462" checksum="E550DDE041E3FCCC" modified="2009-10-13" version="1">MPFSSTSSTSCYGLTLDHPLRPGSPSFKHYRLPTSHSRQANYAQPLHNTTAGILTLTGLGAEPSIMVTGSSGMRVRSPALVGYRERDDTCNGNENKTAPEALERQPKESPEVAKASNQDSGGESSPPCAPTKTSPGTGSVDDRGKLGNESPSCQETSTSQGPGERLQRPRSESSERVRPALRPRHHRSSSMPSFSKTVHFDTKLNNVCYFHKADRPLAVSAGSSPVIGHLEANEYPFYADNDEDLFEWQLFTPNFPRNSLDRESMPVRLERLYLSHDNKHILGSVIVANLAFEKSVICRFTLDYWTTTSETMAVHCCPVPGQMGKYDRFIFSIRLTETVNIESKPIFLCIRYSVNGQEFWDNNLGTNFQSEKIDISVRMQRTRIYAITKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZIK8</accession>
    <name>C7ZIK8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_16945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698931">
        <property type="protein sequence ID" value="EEU36041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041754.1">
        <property type="nucleotide sequence ID" value="XM_003041708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZIK8"/>
    <dbReference type="GeneID" id="9674210"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_16945"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_16945"/>
    <dbReference type="eggNOG" id="ENOG502S3P0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061751_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZIK8"/>
    <dbReference type="OMA" id="GLHAGTW"/>
    <dbReference type="OrthoDB" id="191037at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF30">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="116"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU36041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="350" mass="39589" checksum="9E6F7F2089B1B31D" modified="2009-10-13" version="1" fragment="single">AIASSDPLPVTTEELTPSWFSKVLGKRVKDASIVETIHGTASKILVQLTYEDPADSPTAICVKGGFNPAILALQPSLSQMYQLEAEFYHYIGPTVQMRLPDAHYCAIDEAHQQGIVVLADLKATGYRFGNPLEAWSVERVRAGVEQLAILHARTWGGEPKDFPWLNREFSIRDIMRSLLSAESWEARFGSDSRPPVPDELADRERMARAFETLWSNTDTKMNCIVHGDPHIGNTFITPTGEPGFLDWQCIYRGSAIHDVAYFIAGSLSLNDRRKNDEQLFQHYLDTLHQKGGPRFNKEELWEEYRKHTLHGFIWSLALSEMQPRELVDAMAKRYCAAIIDLKTLDLLESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJY9</accession>
    <name>C7ZJY9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_18558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698936">
        <property type="protein sequence ID" value="EEU35675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041388.1">
        <property type="nucleotide sequence ID" value="XM_003041342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJY9"/>
    <dbReference type="STRING" id="660122.C7ZJY9"/>
    <dbReference type="GeneID" id="9676259"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_18558"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_18558"/>
    <dbReference type="eggNOG" id="ENOG502SX1Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071678_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZJY9"/>
    <dbReference type="OMA" id="HEIWAQH"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU35675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="189" mass="22377" checksum="972B3E0C7A107C7A" modified="2009-10-13" version="1" fragment="single">HDRRFTWGFTIFRTVYTPESDETFPRVIEELNQLARQYVFDDLRSRREPGQEPFDPRPNEELARRFYCDIIQDAASLDGASPDEVGRRFDAWVTEHHLQPPQPVIKMGRFCVCIMLDQQGIDHFLQVNRDKKSFDRAQYDLYVKVVTEFSHENEEGEDRLWMRVGIRGQLWSFACDWPDMDITEIGVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZK02</accession>
    <name>C7ZK02_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_87996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698936">
        <property type="protein sequence ID" value="EEU35680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041393.1">
        <property type="nucleotide sequence ID" value="XM_003041347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZK02"/>
    <dbReference type="GeneID" id="9676267"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87996"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87996"/>
    <dbReference type="eggNOG" id="ENOG502QW87">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011148_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZK02"/>
    <dbReference type="OMA" id="ELNSWWH"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU35680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="454" mass="50338" checksum="4130B9212853BBD0" modified="2009-10-13" version="1">MPGRVSNWPAWSEFLTPPQTVSEDTFAPSATAKGEVIAQYGQDALRQGWLRACKDLETVTERLASLGSDAIPVLELADISREGLSDEQRFILKSSGCCVIRGVLSEEEATDQYQDLKAFLTNNEGAIPGWPSESRVIINVYNSPTQVAIRTHPNHILVQRALNSLYHDKSGETSPEPLSYTDAARIRPPGQSFLGLGPHIDAGSLCRWADPQYRKVYGEILSGHPELHDPYDLDVRKNADQFLFKAQAHSVVFRSFQGWTALTQTSATKGTLLLYPEVKVTVAYLILRPFFAPPPNPEDVMDAEKWTFDPDSNWFPGTIKEQSQRLSPSSHPHLRLKECLSYIPDMKPGDTVWWHTDVGNYQAVWNEEANTAQMCHAVDPDQLGDQDASVVYIASCPTTPINKRYIKEQLEAALAGRSPPDCTSVETDESKLKGYAGFSQVSEEGKSVLGFGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZK20</accession>
    <name>C7ZK20_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_52369</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698937">
        <property type="protein sequence ID" value="EEU35602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041315.1">
        <property type="nucleotide sequence ID" value="XM_003041269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZK20"/>
    <dbReference type="GeneID" id="9675987"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_52369"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_52369"/>
    <dbReference type="eggNOG" id="ENOG502RYZ8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009377_1_1_1"/>
    <dbReference type="InParanoid" id="C7ZK20"/>
    <dbReference type="OMA" id="RILFWHI"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="266"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU35602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="643" mass="71051" checksum="7F9A55B566B5843D" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKH3</accession>
    <name>C7ZKH3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_88966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698939">
        <property type="protein sequence ID" value="EEU35485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041198.1">
        <property type="nucleotide sequence ID" value="XM_003041152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKH3"/>
    <dbReference type="STRING" id="660122.C7ZKH3"/>
    <dbReference type="GeneID" id="9675827"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88966"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88966"/>
    <dbReference type="HOGENOM" id="CLU_1147445_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZKH3"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="242" mass="26788" checksum="72A6FC9F732AB28B" modified="2009-10-13" version="1">MYMVYIRPLTDRWEADRWELYGKMAPPSDFIWHNETGPWESSRSRSKTGAISLSLSARSMLATGGPLGQTLRTATTMTSRSTANYGVTIDVLKRLTAESLDIFGQVSRRWHKFLGCDAQQQSALEPPLLTSSSKRKGAAESGGEEKKCYPPRKRAKIASLETLRAVSVTPARRGRQVGRGEAEPAGCRAANGRREELGLYGPGYASRCRRDHRGGSVRRVEEAAGHTLRRCRPRLQVLARGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZM61</accession>
    <name>C7ZM61_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_39656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698949">
        <property type="protein sequence ID" value="EEU34939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040652.1">
        <property type="nucleotide sequence ID" value="XM_003040606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZM61"/>
    <dbReference type="GeneID" id="9679062"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_39656"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_39656"/>
    <dbReference type="eggNOG" id="ENOG502S44G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020416_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZM61"/>
    <dbReference type="OMA" id="AMKSRLW"/>
    <dbReference type="OrthoDB" id="3437405at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU34939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="638" mass="73170" checksum="001D4DFABC976940" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMY0</accession>
    <name>C7ZMY0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tse2 ADP-ribosyltransferase toxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_34809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698959">
        <property type="protein sequence ID" value="EEU34662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040375.1">
        <property type="nucleotide sequence ID" value="XM_003040329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMY0"/>
    <dbReference type="GeneID" id="9678766"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_34809"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_34809"/>
    <dbReference type="eggNOG" id="ENOG502RPI0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113396_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZMY0"/>
    <dbReference type="OMA" id="HEFRDHY"/>
    <dbReference type="OrthoDB" id="10266325at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041018">
        <property type="entry name" value="ADPRTs_Tse2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18648">
        <property type="entry name" value="ADPRTs_Tse2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tse2 ADP-ribosyltransferase toxin" evidence="1">
        <location>
            <begin position="15"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="165" mass="18902" checksum="93EEB6EBFEFB8336" modified="2009-10-13" version="1">MSTSNLISLFKKFPKELFRVNNDPLVKLRVLRPNRHIYDIVLQNGLALPKALNPSSYIAPNGASLRPNSQYQQSLVSWRFRGNDTIVYSVPEGTTLPDNLLLVHERSDHYSLQPAMAMTTKLLHLDLNTKITQFLMNNAMVFAREEWLEVYPKATETSESKGRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMZ7</accession>
    <name>C7ZMZ7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Plastocyanin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_82322</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698960">
        <property type="protein sequence ID" value="EEU34604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040317.1">
        <property type="nucleotide sequence ID" value="XM_003040271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMZ7"/>
    <dbReference type="STRING" id="660122.C7ZMZ7"/>
    <dbReference type="GeneID" id="9678734"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82322"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82322"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_696552_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZMZ7"/>
    <dbReference type="OMA" id="CTETHPE"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF488">
        <property type="entry name" value="LACCASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="98"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="269"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU34604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="43690" checksum="CFC21D2309304192" modified="2009-10-13" version="1">MTVFRASRSIRSNLEITTHTALLYNSSTGVTSTTVTLVQPSLMHKGAQYGSLPHHGDHDRTRLCHLRWKTSRVWSEPTEGPSEAITAEEGADWIWISFIHSGAHHELQISVDEHEVHVVAADGEFVYPQKVHAANCNLGERIGILVHLNKKPGDYAIRVASLRTEQIIQGLGILRYPSPPKGNAANVPTTKPWVHLNGSLISPTLTAMDETKLAPYLHRPPPAKSDNTVKFLANMTGSGAWALGVGSHQAFRQQLPPLLWDESSRANVTSQHPFHKHNNKAWIIGTGEGGFPWETVADAMEGGAVKNFNSDNPPIRDGCRLGNGTGDWTVIRYEIAFPAVSMLHCHMIHHFGTDRKQAGQQVVLLEGVESMNKVPSYVKDRVHAELVPPFRYGPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZP18</accession>
    <name>C7ZP18_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_96614</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039946.1">
        <property type="nucleotide sequence ID" value="XM_003039900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZP18"/>
    <dbReference type="STRING" id="660122.C7ZP18"/>
    <dbReference type="GeneID" id="9677600"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_96614"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_96614"/>
    <dbReference type="eggNOG" id="ENOG502SKMH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_0_1"/>
    <dbReference type="InParanoid" id="C7ZP18"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF314">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU34233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="38102" checksum="D3F6A26FDABBCAC0" modified="2009-10-13" version="1">MAESKLNIIIVGSGLAGLGAATATGGQGICLFSNCVKILQSMGLDADRSGGVPCHDYRLFDKAGKRLKDFPIDFKGRYGVDTLTMKRSYFREELLMLATAPPADGIKGEPVRMVFNTAVAEVNPEAASATLHDGSVVRGDAVIIADGVHSRLRKRITGDETHRAKKNGDTCYRIASSFAKLKEALGYLPEWWDPETADSRISALQTLDDMNRLVAEESWYANGDRKELISTFADFYELIRKILRELTAIALPKRSRFGTFRTWVLSQTDTEDVPSIRLLLPGMDEDDIKSVLSKIDAVRRPRAAKVLQDTRLQADEITREERLANMDYNCGYNGVYEALKELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZP62</accession>
    <name>C7ZP62_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_96668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040006.1">
        <property type="nucleotide sequence ID" value="XM_003039960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZP62"/>
    <dbReference type="STRING" id="660122.C7ZP62"/>
    <dbReference type="GeneID" id="9677531"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_96668"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_96668"/>
    <dbReference type="eggNOG" id="ENOG502SH5I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012235_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZP62"/>
    <dbReference type="OMA" id="GHFMFWP"/>
    <dbReference type="OrthoDB" id="5416609at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13207">
        <property type="entry name" value="AAA_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12710">
        <property type="entry name" value="HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="1">
        <location>
            <begin position="506"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="724" mass="81287" checksum="280FA7929F8B80D5" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPC7</accession>
    <name>C7ZPC7_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_101813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039832.1">
        <property type="nucleotide sequence ID" value="XM_003039786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZPC7"/>
    <dbReference type="GeneID" id="9677560"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101813"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101813"/>
    <dbReference type="eggNOG" id="ENOG502SKGQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027514_2_2_1"/>
    <dbReference type="InParanoid" id="C7ZPC7"/>
    <dbReference type="OMA" id="CAFVNKL"/>
    <dbReference type="OrthoDB" id="3251507at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU34119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="457" mass="52590" checksum="2285782923914FF1" modified="2009-10-13" version="1">MTVRGIHKFYEPAVLLNALNFTEREAAPPGDFDATIDTTDPRQLFQAFVYKLGHICDSVKGNYGATITSFCVLKDEEKDEAAHYWFTSNQRTREDLETTAEYVRELLGKVGDPDEDLASLKRGLLSDVLWFNRPRLEYYFRQMSDRATKCRGSCLDTDDDEVVHLGTRAIKLLEQLCRSPEGKIIAERAREGRKYGVPSQKCWPDLQHMINRTTAYSESVRFILAAKVRWPGLFDKFKVSFIESSQRMERPFRNKSQTADGIVGRMTRKQKMIDTFREFARDLQRFNLDELIMGVWKDPNFRPIVHAEVLLLDHLDKKGLLEPRFFFNEWMYIGSSKPTCKLCHHYFTLHHVSNVGHRPSHGNLYLHWRFPDVLKSQGETGIQRRQIMVDRVLGEVRKEAFDIVSRKGTSSYKGDDSFTYSAAMPDRSTVAGSVVDLGDLASMIGHMDLSDRAGDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPV4</accession>
    <name>C7ZPV4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_55819</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698974">
        <property type="protein sequence ID" value="EEU33946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039659.1">
        <property type="nucleotide sequence ID" value="XM_003039613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZPV4"/>
    <dbReference type="FunCoup" id="C7ZPV4">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="GeneID" id="9667170"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55819"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55819"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="InParanoid" id="C7ZPV4"/>
    <dbReference type="OMA" id="THGAWEM"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000489">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002989037" description="Major facilitator superfamily (MFS) profile domain-containing protein" evidence="10">
        <location>
            <begin position="21"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="365"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="474"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="8"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU33946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="507" mass="53611" checksum="61AD58D11C6B69B3" modified="2009-10-13" version="1">MGIKLALITISLMLAVLCVALDNTIIAVAIPHITDQFHNLNDVGWYASAYLLTTCALQLLFGKLYALFSVKIVFLSALFVFELGSLICGIAPTSTALIIGRAIAGLGSAGIFTGALVTIAHTVAREKRPIFFGLLGGMYGIASVAGPLMGGAFTDHASWRWCFYINLPLGGVTAAVILLILKLPAKPASKRASFLQVLKGLDPIGTAVFIPSIICLLLALQWGGVKYQWSNARIIVLFVLFGALLVGFVAVQLIMKDDATVPPRIAGNRTIASAALFGFCIGGSFFILTYYIPIWFQVIKNTSAVRSGIYSLPMILANVVGIVGAGSLTTKFGHYAPFFIASAVIMSIGAGLITTFTVHTAQAKWVGYLFIYGFGVGLGFQQGGVAAQAVLPLKDVSIGTAMVMFVQMLGGALFVSVAQNLFTNQLVNNLMALDIPDLHPEAIVHAGATSLRSMIDPEALPEVLTAYNMALVKTFQLALIMSCLSILGALGIEWKSVKGKELAPGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQH7</accession>
    <name>C7ZQH7_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_56187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698995">
        <property type="protein sequence ID" value="EEU33731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039444.1">
        <property type="nucleotide sequence ID" value="XM_003039398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQH7"/>
    <dbReference type="STRING" id="660122.C7ZQH7"/>
    <dbReference type="GeneID" id="9666963"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_56187"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_56187"/>
    <dbReference type="HOGENOM" id="CLU_175959_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZQH7"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU33731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="73" mass="8727" checksum="70F97CEAF6370B1A" modified="2009-10-13" version="1" fragment="single">WRSRCLLDAAWEAYTITLSMVSKMREAIVKTFYEHRELLDEDFVKEFLLEMPYLTLDIMIYMNKPPAVTGVRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQI1</accession>
    <name>C7ZQI1_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_89207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698996">
        <property type="protein sequence ID" value="EEU33719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039432.1">
        <property type="nucleotide sequence ID" value="XM_003039386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQI1"/>
    <dbReference type="GeneID" id="9666956"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89207"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89207"/>
    <dbReference type="HOGENOM" id="CLU_1454801_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZQI1"/>
    <dbReference type="OrthoDB" id="10293280at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU33719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="186" mass="22207" checksum="7292E957ABF81C07" modified="2009-10-13" version="1">MSSDNSDLARLSQTLNIDLDTPAMRARDLTVDLLEPCTPEAYRQAVHYQITEIVKINRPKKIPKPGNQWYLQEMEVQHDKYTLWTQLQDEQAEEFWWFLPWLFGQEAPRDWERFFVWFQQKLTEPVANLAAVRALLAMAKELVFVTLMNAKHRNIYLERYPFAYDTIEDRYTHELWVAEARQRAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZR29</accession>
    <name>C7ZR29_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_56534</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG699027">
        <property type="protein sequence ID" value="EEU33525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039238.1">
        <property type="nucleotide sequence ID" value="XM_003039192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZR29"/>
    <dbReference type="GeneID" id="9666759"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_56534"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_56534"/>
    <dbReference type="eggNOG" id="ENOG502SH5J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006524_0_2_1"/>
    <dbReference type="InParanoid" id="C7ZR29"/>
    <dbReference type="OMA" id="ACEACQA"/>
    <dbReference type="OrthoDB" id="3365636at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF39">
        <property type="entry name" value="TRANSCRIPTION FACTOR PBCR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="7"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU33525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="544" mass="60682" checksum="4816FC533EBF315C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZRC2</accession>
    <name>C7ZRC2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Xaa-Pro dipeptidyl-peptidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_89452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699059">
        <property type="protein sequence ID" value="EEU33437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039150.1">
        <property type="nucleotide sequence ID" value="XM_003039104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZRC2"/>
    <dbReference type="STRING" id="660122.C7ZRC2"/>
    <dbReference type="GeneID" id="9666670"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89452"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89452"/>
    <dbReference type="eggNOG" id="ENOG502SH88">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1235321_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZRC2"/>
    <dbReference type="OrthoDB" id="416441at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase C-terminal" evidence="1">
        <location>
            <begin position="117"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU33437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="224" mass="25492" checksum="057F17A3557E6C5E" modified="2009-10-13" version="1">MACYWAGMFQPPHLAAIAPYEGLTDMYGETWRSEGPWPVFDRTRDLSKLKVPILSAGNWMDSEVHFPGNLAAFERSSSRWKFLEIHTGNHIASYYEPAQTERQLIFFDYFLKGKTDNGLEATPRIDLLIRRGTNNSYRVEESWPPQDTIYTSLYLAPDEALSFDEFAASSEDDAISSAGLTGKDLFQSAPLKDFEILGYPNLDLAVSTDAKDMDIFIYFCHRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7YGY2</accession>
    <name>C7YGY2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_74781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053536.1">
        <property type="nucleotide sequence ID" value="XM_003053490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YGY2"/>
    <dbReference type="GeneID" id="9676868"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74781"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74781"/>
    <dbReference type="eggNOG" id="ENOG502S78G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065222_1_0_1"/>
    <dbReference type="InParanoid" id="C7YGY2"/>
    <dbReference type="OMA" id="MGNHIAD"/>
    <dbReference type="OrthoDB" id="408760at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00229">
        <property type="entry name" value="SGNH_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF19">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU47823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="241" mass="27675" checksum="572021ADDFD54FF0" modified="2009-10-13" version="1">MGRKTLRILCFGDSLTSGYFCWGMGSHPYALKLEDRLTGAFPDVDFEVVADGQPGDVASFERFRKRMEAAWSKKTYDWTIILGGTNDIAYAIPPVQIFEALKEVYDIALSREHKVLALTVPECEAKGERGIESRHELNQMILNNKDTNYYSFDLHAHIPFHSLSEADREKYWDDGLHLRDDGYDWMGNHIANALIDILRREDTLGSPSQLEFEDDFVFEEEEGNPRKISEGYVVVRKKDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7YH55</accession>
    <name>C7YH55_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_98809</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053572.1">
        <property type="nucleotide sequence ID" value="XM_003053526.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9664443"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_98809"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98809"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003548_0_0_1"/>
    <dbReference type="InParanoid" id="C7YH55"/>
    <dbReference type="OMA" id="ETDWTEM"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF48">
        <property type="entry name" value="PROTEIN VAPYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="531"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="564"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="693"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="875"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1475"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="591"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1039"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1171"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1834"/>
            <end position="1863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="598"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="630"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="663"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1171"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1840"/>
            <end position="1860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU47859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1877" mass="212431" checksum="CC87D3E83990F7B8" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7YH93</accession>
    <name>C7YH93_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_90127</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad21 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054307.1">
        <property type="nucleotide sequence ID" value="XM_003054261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YH93"/>
    <dbReference type="FunCoup" id="C7YH93">
        <property type="interactions" value="187"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YH93"/>
    <dbReference type="GeneID" id="9664463"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90127"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90127"/>
    <dbReference type="eggNOG" id="KOG1213">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015775_0_1_1"/>
    <dbReference type="InParanoid" id="C7YH93"/>
    <dbReference type="OMA" id="HTDLYEP"/>
    <dbReference type="OrthoDB" id="10071381at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030892">
        <property type="term" value="C:mitotic cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21788">
        <property type="entry name" value="Rad21_Rec8_M_SpRad21p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.580:FF:000004">
        <property type="entry name" value="Double-strand-break repair protein rad21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF69">
        <property type="entry name" value="FI11703P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="5">
        <location>
            <begin position="509"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU48594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="595" mass="65378" checksum="032CEC90920A5359" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIF7</accession>
    <name>C7YIF7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 25">tRNA-dihydrouridine(47) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="4 25">1.3.1.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">tRNA-dihydrouridine synthase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">NECHADRAFT_75304</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>5,6-dihydrouridine(47) in tRNA + NAD(+) = uridine(47) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53364"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="20">
            <dbReference type="Rhea" id="RHEA:53366"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>5,6-dihydrouridine(47) in tRNA + NADP(+) = uridine(47) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53360"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="23">
            <dbReference type="Rhea" id="RHEA:53362"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="22">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 25">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="25">Belongs to the dus family. Dus3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.89" evidence="4 25"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053802.1">
        <property type="nucleotide sequence ID" value="XM_003053756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIF7"/>
    <dbReference type="FunCoup" id="C7YIF7">
        <property type="interactions" value="894"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YIF7"/>
    <dbReference type="GeneID" id="9676430"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75304"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75304"/>
    <dbReference type="eggNOG" id="KOG2333">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013299_7_0_1"/>
    <dbReference type="InParanoid" id="C7YIF7"/>
    <dbReference type="OMA" id="WSYIAEC"/>
    <dbReference type="OrthoDB" id="259935at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106414">
        <property type="term" value="F:mRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102265">
        <property type="term" value="F:tRNA-dihydrouridine47 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000145">
        <property type="entry name" value="tRNA-dihydrouridine(47) synthase [NAD(P)(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25585">
        <property type="entry name" value="zf-CCCH_DUS3L"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 25" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 25" id="KW-0288">FMN</keyword>
    <keyword evidence="11 24 25" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="17 25" id="KW-0520">NAD</keyword>
    <keyword evidence="15 25" id="KW-0521">NADP</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16 25" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 25" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="14 24 25" id="KW-0862">Zinc</keyword>
    <keyword evidence="13 24 25" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="27">
        <location>
            <begin position="171"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="24">
        <location>
            <begin position="171"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="26">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="59"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="26">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="26">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="RuleBase" id="RU291113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="EEU48089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="770" mass="86328" checksum="B206AEA4ECE17012" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIR3</accession>
    <name>C7YIR3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_75415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053852.1">
        <property type="nucleotide sequence ID" value="XM_003053806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIR3"/>
    <dbReference type="GeneID" id="9676486"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75415"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75415"/>
    <dbReference type="eggNOG" id="ENOG502T382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062863_0_0_1"/>
    <dbReference type="InParanoid" id="C7YIR3"/>
    <dbReference type="OMA" id="WIVWINI"/>
    <dbReference type="OrthoDB" id="4818293at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU48139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="373" mass="42366" checksum="7D83C282F68A2E53" modified="2009-10-13" version="1">MGIEEKWNVLRPQQKRARRSFISIIGFGVNIHRTSAHMSLPMMLSSLVRPTRKGISDGLLILAMIGGVISLILAFIVFIAGTTIIPGSGDNPDHLFWKPLALVTFDGLVPNNDTSKFLVQLNWYASSFGWEYPNAPKNLPKAGITSSGLRWSSNIVNDLHQIARDLNLPQDTWDCPKFGAYEDPCGNIFFEAWRTYMVHNGLPISSWLLWVMVTSALVLGSWTMVQEWMIQKRPHWMRCRCIIGKRWCPCPKGTKEEIENHDDFVWDKVRLSYWTLSAAYFGTAATHACVTSVFFVKFLGFFEERLPEGISMRPRRRIASEVLLWVAFGIRCFSALCMAIRWKLSRRPKGWLDGQSVGLDGDSGRPGDARYTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJT7</accession>
    <name>C7YJT7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Delta-1-pyrroline-5-carboxylate dehydrogenase</fullName>
                <shortName evidence="8">P5C dehydrogenase</shortName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
                <ecNumber evidence="7">1.2.1.88</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_31765</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamate 5-semialdehyde + NAD(+) + H2O = L-glutamate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="7"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU49032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054745.1">
        <property type="nucleotide sequence ID" value="XM_003054699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJT7"/>
    <dbReference type="STRING" id="660122.C7YJT7"/>
    <dbReference type="GeneID" id="9663978"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_31765"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_31765"/>
    <dbReference type="eggNOG" id="KOG2455">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_4_1_1"/>
    <dbReference type="InParanoid" id="C7YJT7"/>
    <dbReference type="OMA" id="VIHERSW"/>
    <dbReference type="OrthoDB" id="5322683at2759"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:L-glutamate gamma-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000006">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000005">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050485">
        <property type="entry name" value="Proline_metab_enzyme"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862:SF1">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="39"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU49032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="527" mass="57866" checksum="83F86A535D7BE6E8" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLX6</accession>
    <name>C7YLX6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cysteine proteinase 1, mitochondrial</fullName>
            <ecNumber evidence="8">3.4.22.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_35505</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.</text>
    </comment>
    <comment type="function">
        <text evidence="6">The normal physiological role of the enzyme is unknown, but it is not essential for the viability of yeast cells. Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. Acts as a repressor in the GAL4 regulatory system, but this does not require either the peptidase or nucleic acid-binding activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred.</text>
            <dbReference type="EC" id="3.4.22.40"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homohexamer. Binds to nucleic acids. Binds single-stranded DNA and RNA with higher affinity than double-stranded DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.40" evidence="8"/>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053065.1">
        <property type="nucleotide sequence ID" value="XM_003053019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YLX6"/>
    <dbReference type="FunCoup" id="C7YLX6">
        <property type="interactions" value="719"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YLX6"/>
    <dbReference type="MEROPS" id="C01.085"/>
    <dbReference type="GeneID" id="9663906"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_35505"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_35505"/>
    <dbReference type="eggNOG" id="KOG4128">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038600_0_1_1"/>
    <dbReference type="InParanoid" id="C7YLX6"/>
    <dbReference type="OMA" id="QSYTFFW"/>
    <dbReference type="OrthoDB" id="2666448at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070005">
        <property type="term" value="F:cysteine-type aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043418">
        <property type="term" value="P:homocysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00585">
        <property type="entry name" value="Peptidase_C1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000021">
        <property type="entry name" value="Bleomycin hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004134">
        <property type="entry name" value="Peptidase_C1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363:SF2">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03051">
        <property type="entry name" value="Peptidase_C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005700">
        <property type="entry name" value="PepC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0788">Thiol protease</keyword>
    <feature type="active site" evidence="9">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005700-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU47352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="499" mass="55883" checksum="1B8C809C4DD98AFC" modified="2009-10-13" version="1">MGAQQSKTEPTLHEKAVLERLQNLRVQDQDDYVEVTSDAEKAFVGPLIRDAEGLPLHVLESWQAAIIKDPKNNSANPRQVLTSLPTQIADQQIYNVKIPFEGDPITNQRSSGRCWLFASTNVFRVALMKRFDLESFELSQQYLFYWDKLEKANWFLEQIIDTATEDLEGRVVQTLLSDLVSDGGQWDMVYNLVEKYGLVPQTLYPDSWNAMSSGILNSLVKTKLREFALRLRALANSKDGVSAAAISSAKDKMLREISLIMTLLLGPPPNPEETFTWQYNDKNGKAHQLKTTPKEFAKNIYSPSFPVTSSTVSGMISLVHDPRHEPLSHLTVSRLGNIVGGRGISYVNVDIDTLKGACVKMLKAGLPIFFGSDVGQFSDSRSGIMDLNLYNYELGFNTSLLGMTKAQRLMTGESQMTHAMVLTAVHLDEQTGKPVRWRVQNSWGTTAGDKGWFVMSDAWLDEFVYQAVVDPRVLSKEVRDVLKKEAIVLPLWDPMGSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7YMW0</accession>
    <name>C7YMW0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DJ-1/PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_36000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053229.1">
        <property type="nucleotide sequence ID" value="XM_003053183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YMW0"/>
    <dbReference type="STRING" id="660122.C7YMW0"/>
    <dbReference type="GeneID" id="9664220"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_36000"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_36000"/>
    <dbReference type="eggNOG" id="ENOG502S46I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_44_8_1"/>
    <dbReference type="InParanoid" id="C7YMW0"/>
    <dbReference type="OMA" id="MDGTFNT"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd03139">
        <property type="entry name" value="GATase1_PfpI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF15">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="1">
        <location>
            <begin position="10"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU47516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="230" mass="25187" checksum="13D5B51931C9C691" modified="2009-10-13" version="1">MAQTPKKYGVVLYEGFQLIDVCGPVDVLNVLTTHVEGISLSVISESLQPTSTFPKTWPDKMGMPPFTTSQLITPTHTFETAPQLDVLIIPGGMGCFDPDPNNAGQPNPAVVNPIIKFIQKQYPGLKYLVTVCTGSGITSLSGLLDGKKATTFKGAWKVIPAWRPQVEWVPSARWVVDGNIWTSSGVCSGIDLMFGFVKEVYGERIAQEIAVWMEYQRHEDPTIDPFGIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNF2</accession>
    <name>C7YNF2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase S8/S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_36288</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052823.1">
        <property type="nucleotide sequence ID" value="XM_003052777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNF2"/>
    <dbReference type="STRING" id="660122.C7YNF2"/>
    <dbReference type="GeneID" id="9671355"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_36288"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_36288"/>
    <dbReference type="eggNOG" id="ENOG502S098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006016_4_0_1"/>
    <dbReference type="InParanoid" id="C7YNF2"/>
    <dbReference type="OMA" id="DEEWISH"/>
    <dbReference type="OrthoDB" id="5093543at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07491">
        <property type="entry name" value="Peptidases_S8_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="6">
        <location>
            <begin position="257"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU47110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="559" mass="62586" checksum="1BBA97CE3D82EF88" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPB3</accession>
    <name>C7YPB3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_122473</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051527.1">
        <property type="nucleotide sequence ID" value="XM_003051481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YPB3"/>
    <dbReference type="GeneID" id="9668604"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_122473"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_122473"/>
    <dbReference type="eggNOG" id="ENOG502SE9H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007974_0_1_1"/>
    <dbReference type="InParanoid" id="C7YPB3"/>
    <dbReference type="OMA" id="LWNVYYH"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024119">
        <property type="entry name" value="TF_DEAF-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237">
        <property type="entry name" value="DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG SUPPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237:SF15">
        <property type="entry name" value="LD37257P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="1135"/>
            <end position="1176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU45814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1179" mass="130433" checksum="8B147A1C63D02AF1" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPZ8</accession>
    <name>C7YPZ8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_38032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052093.1">
        <property type="nucleotide sequence ID" value="XM_003052047.1"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YPZ8"/>
    <dbReference type="GeneID" id="9668880"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_38032"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_38032"/>
    <dbReference type="eggNOG" id="KOG0929">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001772_0_0_1"/>
    <dbReference type="InParanoid" id="C7YPZ8"/>
    <dbReference type="OMA" id="FYTSIQK"/>
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    </dbReference>
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        <property type="entry name" value="PH AND SEC7 DOMAIN-CONTAINING PROTEIN C11E3.11C"/>
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            <end position="766"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="131"/>
        </location>
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        </location>
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            <end position="1226"/>
        </location>
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            <begin position="1357"/>
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        </location>
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        </location>
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            <end position="209"/>
        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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            <end position="431"/>
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        </location>
    </feature>
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        </location>
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        </location>
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    </feature>
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    </feature>
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        </location>
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        </location>
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        <location>
            <begin position="1363"/>
            <end position="1381"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEU46380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1381" mass="150501" checksum="4EA49C4EB97070A8" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQJ0</accession>
    <name>C7YQJ0_FUSV7</name>
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        <recommendedName>
            <fullName evidence="9">40S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">NECHADRAFT_9492</name>
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        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
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            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
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    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uS13 family.</text>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
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            <position position="1"/>
        </location>
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            <position position="131"/>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="15260" checksum="5D9B7996724ABC18" modified="2009-10-13" version="1" fragment="single">ILRLLNTNVDGKQKVMYALTKIKGVGRRYSNLVCKKADVDLNKRAGELTSEELERIVTIIQNPTQYKIPTWFLNRQRDIVDGKDSHILANGVDSKLREDLERLKKIRAHRGLRHYWGLRVRGQHTKTTGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQP4</accession>
    <name>C7YQP4_FUSV7</name>
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        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="1" type="ORF">NECHADRAFT_79176</name>
    </gene>
    <organism evidence="1 2">
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        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051771.1">
        <property type="nucleotide sequence ID" value="XM_003051725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQP4"/>
    <dbReference type="GeneID" id="9673597"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79176"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79176"/>
    <dbReference type="eggNOG" id="ENOG502RQ1J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_721697_0_0_1"/>
    <dbReference type="InParanoid" id="C7YQP4"/>
    <dbReference type="OMA" id="VCIFINS"/>
    <dbReference type="OrthoDB" id="5050657at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU46058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="48782" checksum="92812AA210FE9F5F" modified="2009-10-13" version="1">MAKRKLTFHELPQDCYNAIAGFTDGASLDSLTRASKRYYDAFAQSNFEEIRFDDTQGYLSCKLRAFLLLKTNTNMNQIRQHIRVATINLRYTHLDSSMAGDYPLANDEEDEHLVSRIVDALTRMTALQNLTLDLEGFSAQQSLSFSVQLGPTRRWDIIHTLRLNAPSVDGPPAIDIRPVGVRLPPPQPWEDNYNLPPGVFSAVLDHCDAKVLKAIHLYKWYGSREYDAVKRKYRDRTGDDPHNPPSRQLHKLHLYHDHPKSAYHKCTPTFDVDVLDSIIEDFPYLQWLILSEKPYTIRGVSRDRRGILSKAETLAQRVQSSRLKRLAFDLRRTRFHGRVIRKDFAAAFVEEGPREISEEEVDDWYSTLIRLMFEHAPRLEQLVIFDNFPIYHIGTRSSSGPMLVRRETLVGTKHSSAFPRGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQW6</accession>
    <name>C7YQW6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-aminobutyrate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GABA aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-amino-N-butyrate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_68543</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23352"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="2.6.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.19" evidence="3"/>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051803.1">
        <property type="nucleotide sequence ID" value="XM_003051757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQW6"/>
    <dbReference type="STRING" id="660122.C7YQW6"/>
    <dbReference type="GeneID" id="9673712"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_68543"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_68543"/>
    <dbReference type="eggNOG" id="KOG1405">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_12_0_1"/>
    <dbReference type="InParanoid" id="C7YQW6"/>
    <dbReference type="OMA" id="ERIMTTW"/>
    <dbReference type="OrthoDB" id="10260828at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034386">
        <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000029">
        <property type="entry name" value="4-aminobutyrate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004631">
        <property type="entry name" value="4NH2But_aminotransferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00699">
        <property type="entry name" value="GABAtrns_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206:SF1">
        <property type="entry name" value="4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU46090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="463" mass="51614" checksum="63E064DEEDA1D84A" modified="2009-10-13" version="1">MPAFVETPKTTVTTEIPGPVSKASTKRLDAIFDARAVHFVVDYDKSHDNYIVDVDGNKYLDVYAQIASIPVGYNNETLIEAAKSPEMASALVNRPAMGNFPSDQWVDILRNGLMKVAPKGLSYIFTAQSGSEANELAYKAAFMLYRRRQRGEGVDWNDEEINSCLENSKPGSPELAIMSFSNSFHGRGFGSLSTTRSKAVHKLDIPSFNWPQAPFPALKYPLEEHTEENAAEEKRCLEEVERLITSWHCPVAGLIVEPIQSEGGDNHASPAFFQGLRDITKRHGTCLIADEVQTGFGATGSFWGHDHWNLTSPPDMVTFSKKAQTAGYFFGNEMLIPDKAYRQFNTWIGDPARVIMCKAVIQEILDKKLVEQTARVGHHLYNELARLATKYPEYIKNLRGKDQGTFIAFDTKDPAALVRSMRHIGVNIGTCGKNTVRLRPMLIFEEKHVPILVNAFDKVIGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRY8</accession>
    <name>C7YRY8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Imidazole glycerol phosphate synthase hisHF</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="12">Glutaminase</fullName>
                <ecNumber evidence="12">3.5.1.2</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="12">Cyclase</fullName>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="17" type="ORF">NECHADRAFT_41455</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">In the C-terminal section; belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="12"/>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051260.1">
        <property type="nucleotide sequence ID" value="XM_003051214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YRY8"/>
    <dbReference type="FunCoup" id="C7YRY8">
        <property type="interactions" value="290"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YRY8"/>
    <dbReference type="GeneID" id="9666034"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_41455"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_41455"/>
    <dbReference type="eggNOG" id="KOG0623">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037550_0_0_1"/>
    <dbReference type="InParanoid" id="C7YRY8"/>
    <dbReference type="OMA" id="GNYGHFV"/>
    <dbReference type="OrthoDB" id="10254903at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000094">
        <property type="entry name" value="Imidazole glycerol phosphate synthase hisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000039">
        <property type="entry name" value="Imidazole glycerol phosphate synthase hisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050064">
        <property type="entry name" value="IGPS_HisA/HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014640">
        <property type="entry name" value="IGPS_HisHF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235:SF2">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISF/H IGP SYNTHASE SUBUNIT HISF/H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036936">
        <property type="entry name" value="IGPS_HisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51274">
        <property type="entry name" value="GATASE_COBBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 12 15" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="16">
        <location>
            <begin position="6"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="359"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="397"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="469"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="495"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="518"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="14">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR036936-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR036936-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEU45547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="549" mass="59982" checksum="9878EBFEC5EBEC25" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7YS21</accession>
    <name>C7YS21_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small ribosomal subunit protein bS18m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_80585</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050882.1">
        <property type="nucleotide sequence ID" value="XM_003050836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YS21"/>
    <dbReference type="FunCoup" id="C7YS21">
        <property type="interactions" value="138"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YS21"/>
    <dbReference type="GeneID" id="9668124"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_80585"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_80585"/>
    <dbReference type="eggNOG" id="KOG3162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082177_0_0_1"/>
    <dbReference type="InParanoid" id="C7YS21"/>
    <dbReference type="OMA" id="WDAGDVY"/>
    <dbReference type="OrthoDB" id="21463at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_bS18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_bS18_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="28"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU45169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="212" mass="24292" checksum="6BC1F6FDEDB10F30" modified="2009-10-13" version="1">MPPRLPTTTAAEAVRAFVRPFSCTASAALPPRDPFTGSTHTSRLANLNSNRRGADRSPRVQPGDAAARMMERYKARDASFVREKTAQMEFLRNQKMSSDFLKQMPRRWEVGDVYSPHDLSPVEMQKWRKRSVRNVDVVDALGISPLDMYKNFSLIEHFTSPSGMINHSQLTRLRPVNQRKVAKMVRRVQGMGIYPTIHAHPEMLRDQFFGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7YS70</accession>
    <name>C7YS70_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphotyrosine protein phosphatase I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_102677</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050910.1">
        <property type="nucleotide sequence ID" value="XM_003050864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YS70"/>
    <dbReference type="FunCoup" id="C7YS70">
        <property type="interactions" value="598"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YS70"/>
    <dbReference type="GeneID" id="9668145"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102677"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102677"/>
    <dbReference type="eggNOG" id="KOG3217">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071415_2_0_1"/>
    <dbReference type="InParanoid" id="C7YS70"/>
    <dbReference type="OMA" id="YQQVTRF"/>
    <dbReference type="OrthoDB" id="3388at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004726">
        <property type="term" value="F:non-membrane spanning protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16343">
        <property type="entry name" value="LMWPTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000105">
        <property type="entry name" value="Low molecular weight phosphotyrosine protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050438">
        <property type="entry name" value="LMW_PTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002115">
        <property type="entry name" value="Tyr_Pase_low_mol_wt_mml"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717:SF7">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00720">
        <property type="entry name" value="MAMMALPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="Phosphotyrosine protein phosphatases I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphotyrosine protein phosphatase I" evidence="9">
        <location>
            <begin position="5"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR617867-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU45197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="162" mass="18209" checksum="30238A0D266E0DCA" modified="2009-10-13" version="1">MSEPVAVLFVCLGNICRSPMAEGIFQNLAKQPEVGGRIGRIDSCGTAAYHSGEPPDDRTMATLEANGITDYDHLARRFHPSDFNKFDYIFAMDRSNLSDLHRLQKNNPDSKAKVMLFGEFSGTKRPEIVNDPYYGGNEGFSKAFEQCSRFSKNFLKEILEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7YS80</accession>
    <name>C7YS80_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_80644</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051302.1">
        <property type="nucleotide sequence ID" value="XM_003051256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YS80"/>
    <dbReference type="STRING" id="660122.C7YS80"/>
    <dbReference type="GeneID" id="9668149"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_80644"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_80644"/>
    <dbReference type="eggNOG" id="ENOG502SKP9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_8_5_1"/>
    <dbReference type="InParanoid" id="C7YS80"/>
    <dbReference type="OMA" id="VRMKAMD"/>
    <dbReference type="OrthoDB" id="300709at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU45589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="333" mass="35888" checksum="1D2FE2EB23800FBF" modified="2009-10-13" version="1">MSSPQLITVYGATGAQGGSVVQSLLQNKSQAFKIRGITRNPDSDKAKALKEQGVEVVKADGLVKKEVVEAFKDSWGVFVNTNSDDPAVSQPGGPSETDLGKSIVDAAAEAGVRHFVYSGMASASEITGGAVPNKAFEEKHAIGEYAKNKGVFDTVNIVSPGWYMENHLVEEVAPVLGGFPFTPDEEGYLTLHIPRWGGNDEIPFIAIGDDYGDIVHGIFLDPSKHNGRLTQGISSSSKPEQLVSDFEKLTGKKARFVSIEDWKTMETYGVEAFETVKYMFGFCQHSGGLYYGVPNDVVTTGELKAKAAEAKGESGDNAKLMTLERFLGKYFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSK1</accession>
    <name>C7YSK1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_41392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050973.1">
        <property type="nucleotide sequence ID" value="XM_003050927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSK1"/>
    <dbReference type="STRING" id="660122.C7YSK1"/>
    <dbReference type="GeneID" id="9666216"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_41392"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_41392"/>
    <dbReference type="eggNOG" id="ENOG502S5SG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065859_1_0_1"/>
    <dbReference type="InParanoid" id="C7YSK1"/>
    <dbReference type="OMA" id="RTHLNPW"/>
    <dbReference type="OrthoDB" id="5041285at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01821">
        <property type="entry name" value="Rhamnogalacturan_acetylesterase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695:SF2">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988247" description="SGNH hydrolase-type esterase domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="29"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU45260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="242" mass="25978" checksum="D780DE1D95AA80DC" modified="2009-10-13" version="1">MKFSSAFLYVLSSLGVAQAAKPPYFILTGDSTVAVNGGWGDGFLADLKSPASGVNSGKSGATIPSFRAEGRWNTAIEAVKSHKGAHESIVTIQFGHNDQKTYTLEQYSNNLIGLVNEVKAAGGTPIVITSLTRRTFSGGHVVENLAEWRDAAIAVANDLNVKYLDLNTASTNYVNAIGQANADYYNLSQGDRTHLNPAGEIVFGRLVADLLLEKRPDLKKYVVPNEALSKKIRDGEFATGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSN6</accession>
    <name>C7YSN6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_80798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051384.1">
        <property type="nucleotide sequence ID" value="XM_003051338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSN6"/>
    <dbReference type="GeneID" id="9666309"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_80798"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_80798"/>
    <dbReference type="HOGENOM" id="CLU_1283559_0_0_1"/>
    <dbReference type="InParanoid" id="C7YSN6"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU45671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="215" mass="22891" checksum="A8D4C3D0C7B46682" modified="2009-10-13" version="1">MGPKLIAVISEPSEDARRGSPVPGTSKTDAEVTTKKSVLGSAVTPDVTTVPQNQVDGSATLNHKNSSQESSKTGKISGSKKDSASSSGDSSKSTIGSDDQVFVKPPPEAGSESDISSSRASSQLSDESHPTAEVLGVIERYLKGFLKALAWHRFARGIQRKVAAHHSESSILDPGRSELREVITNMKIENWVTMATEALRSRTQTDDQALYNQGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSV5</accession>
    <name>C7YSV5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative phospholipase</fullName>
            <ecNumber evidence="4">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_61471</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30909"/>
            <dbReference type="ChEBI" id="CHEBI:36707"/>
            <dbReference type="EC" id="3.1.1.47"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine esterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.47" evidence="4"/>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051015.1">
        <property type="nucleotide sequence ID" value="XM_003050969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSV5"/>
    <dbReference type="STRING" id="660122.C7YSV5"/>
    <dbReference type="GeneID" id="9668427"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_61471"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_61471"/>
    <dbReference type="eggNOG" id="KOG3847">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022501_3_0_1"/>
    <dbReference type="InParanoid" id="C7YSV5"/>
    <dbReference type="OMA" id="KYWEVHV"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016715">
        <property type="entry name" value="PAF_acetylhydro_eukaryote"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF11">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018169">
        <property type="entry name" value="PAF_acetylhydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR018169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR018169-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU45302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="521" mass="57993" checksum="89A38015A19A34FF" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7YTC2</accession>
    <name>C7YTC2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell wall biogenesis protein Mhp1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_104404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050723.1">
        <property type="nucleotide sequence ID" value="XM_003050677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YTC2"/>
    <dbReference type="STRING" id="660122.C7YTC2"/>
    <dbReference type="GeneID" id="9665741"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_104404"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_104404"/>
    <dbReference type="eggNOG" id="ENOG502QYHN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004016_0_0_1"/>
    <dbReference type="InParanoid" id="C7YTC2"/>
    <dbReference type="OMA" id="ECPSLCH"/>
    <dbReference type="OrthoDB" id="8436363at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="990"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU45010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1148" mass="125165" checksum="8A4FEA93FC178D07" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>C7YTS2</accession>
    <name>C7YTS2_FUSV7</name>
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        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_49386</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050007.1">
        <property type="nucleotide sequence ID" value="XM_003049961.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="C7YTS2">
        <property type="interactions" value="950"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YTS2"/>
    <dbReference type="GeneID" id="9674792"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_49386"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_49386"/>
    <dbReference type="eggNOG" id="KOG0920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_4_0_1"/>
    <dbReference type="InParanoid" id="C7YTS2"/>
    <dbReference type="OMA" id="LFRVCNM"/>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEAD/DEAH box helicase, putative"/>
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    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001214">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056328">
        <property type="entry name" value="DSRM_DHX29"/>
    </dbReference>
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        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059023">
        <property type="entry name" value="RNA_hel_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
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        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24385">
        <property type="entry name" value="DSRM_DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="8">
        <location>
            <begin position="278"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="591"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="828"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU44294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1349" mass="149664" checksum="5D6E38ABF99159D9" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7YU50</accession>
    <name>C7YU50_FUSV7</name>
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        <recommendedName>
            <fullName evidence="7">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_84803</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050454.1">
        <property type="nucleotide sequence ID" value="XM_003050408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YU50"/>
    <dbReference type="STRING" id="660122.C7YU50"/>
    <dbReference type="GeneID" id="9674850"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84803"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84803"/>
    <dbReference type="eggNOG" id="KOG0779">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007693_0_0_1"/>
    <dbReference type="InParanoid" id="C7YU50"/>
    <dbReference type="OMA" id="GWDKDWH"/>
    <dbReference type="OrthoDB" id="442460at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070139">
        <property type="term" value="F:SUMO-specific endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057501">
        <property type="entry name" value="DeUb_enz_PH"/>
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    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051947">
        <property type="entry name" value="Sentrin-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896:SF3">
        <property type="entry name" value="FI06413P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25424">
        <property type="entry name" value="PH_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="7">
        <location>
            <begin position="511"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="435"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="655"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="819"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="894"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1025"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="205"/>
            <end position="227"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="435"/>
            <end position="454"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="662"/>
            <end position="674"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="830"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="983"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1037"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU44741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1046" mass="116826" checksum="E91908BDFC2A1140" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>C7YUK1</accession>
    <name>C7YUK1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ABC transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NECHADRAFT_96330</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="EEU44424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050137.1">
        <property type="nucleotide sequence ID" value="XM_003050091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YUK1"/>
    <dbReference type="GeneID" id="9665581"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_96330"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_96330"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_17_8_1"/>
    <dbReference type="InParanoid" id="C7YUK1"/>
    <dbReference type="OMA" id="NYDNHKQ"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000057">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF11">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="690"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="734"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="811"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="837"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="919"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="952"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="43"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="368"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="694"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1016"/>
            <end position="1265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU44424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1270" mass="138919" checksum="B0D3F8D6243F007B" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVE2</accession>
    <name>C7YVE2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase small domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_48542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050677.1">
        <property type="nucleotide sequence ID" value="XM_003050631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVE2"/>
    <dbReference type="GeneID" id="9675069"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_48542"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_48542"/>
    <dbReference type="eggNOG" id="KOG2793">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030437_1_0_1"/>
    <dbReference type="InParanoid" id="C7YVE2"/>
    <dbReference type="OMA" id="ESHYELF"/>
    <dbReference type="OrthoDB" id="433955at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF147">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE OF THE SEVEN BETA-STRAND FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU44964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="43050" checksum="1D765DD1B1AE6B0A" modified="2009-10-13" version="1">MSSSSALQPPSSSLPPLFTLTKLAEADVINALHQLAAIYCPLSFPFSQELSSQAKHDITQLDVDSGYTSGNEDEDTNNSKQTITTLRADAFERSFVERWLTGFISRAETLSIFSSEESSQRAVDQAAYIFESLFTPAVDEDEQDTSFMRSFSFDTQIPGQAKGKIKVQLNDELAGTTDTDYQDVGLQSWGASIVFSEIMCASPARFGLQNIPSTSDTRIIELGAGTGLVSLALGKLLPSLGVRDSKIIATDYHPAVLDNLQSNIALNYPKDGSSSISAFPLDWASPSHEHPFDVPATMLLATDVVYALEHARLLCHCATQILAEGGTFWMLITIRSEGKFAGILNTVEDAFGASDRPRGKSGRRLEILEHEKLDKRSGVGRGDESGYELFRIGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVF4</accession>
    <name>C7YVF4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_96488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050680.1">
        <property type="nucleotide sequence ID" value="XM_003050634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVF4"/>
    <dbReference type="GeneID" id="9675078"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_96488"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_96488"/>
    <dbReference type="eggNOG" id="ENOG502SJGS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_2_3_1"/>
    <dbReference type="InParanoid" id="C7YVF4"/>
    <dbReference type="OMA" id="IQPEYTP"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU44967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="35810" checksum="7552470F283F10C2" modified="2009-10-13" version="1">MTGRNAPDHDTASSTESLRSSIIDYRQENGRTYHRYKDGKYNLPNDELENERLDLQHHMFLLTFDNKLGLSPPNLPDSKPARILDLGTGTGLWAIDFGDEHPEAEAFDLSPIQPGFVPPNVQFLVDDIDEEWNYSEPFDYIHSRMMNFSIQNWTEYLQKMFQNLVPGGYAELQEMDGFYASDDGTLSDDHALSRWCTLLGEAAVKLGRSFQPTDQLAAIMKQVGFIDVVETRFKWPINRWPKEKKYKELGAWNNQNASQVLESATLAPFTRVLGWSAEEVNLFLIDVRKDLNNPDIHAYSQVRSVYGRKPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVI8</accession>
    <name>C7YVI8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_89566</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049715.1">
        <property type="nucleotide sequence ID" value="XM_003049669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVI8"/>
    <dbReference type="GeneID" id="9677458"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89566"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89566"/>
    <dbReference type="eggNOG" id="ENOG502RX9H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027816_3_1_1"/>
    <dbReference type="InParanoid" id="C7YVI8"/>
    <dbReference type="OMA" id="HYDSENQ"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF683">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="45"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU44002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="468" mass="50393" checksum="9B727E5E6D8618A6" modified="2009-10-13" version="1">MSHYDSENRVPEAPTKAHHVEDEPGVTNDAVFGTIHQDGPNYRNVGWLGTSVLMMKSQIGLGVLSIPASFDVLGLIPGVVCLLVIAVLTTWSDYIVGRFKLRHPEVYGIDDAAGLMFGRVGKEVYGISYALYTICIAGSGMLGISIALNTLSTHATCTAVYVAVACIVAFITASVRTLDRVSWLAWIGLVTLVSAIFVVTVAVGVQDRPDAAPQVGEWKSDYKLVNSPSFADAISAISAFVFAYAGTPVFFPIAAEMREPRHYKKALFLCQAVVTVTYIVVGIVVYYYCGTYVASPALGSAGKTIKKISYGLALPGLIVSACLYTHVPAKYAFIRFLRGSKHLTANTFTHWSTWLGCTFAMAVIAYIIASGIPVFGGLVSLVGALLGTFQCLQPMGCMWLFDNWHKGKNKEQRTIKWTLMAIWSVFIIVIGTFLMIGGTYGSIVGIINSYNKSGGSAAWSCADNSNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVP3</accession>
    <name>C7YVP3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">NECHADRAFT_56813</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049745.1">
        <property type="nucleotide sequence ID" value="XM_003049699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVP3"/>
    <dbReference type="MEROPS" id="S53.010"/>
    <dbReference type="GeneID" id="9677116"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_56813"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_56813"/>
    <dbReference type="eggNOG" id="ENOG502QR6D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013783_3_3_1"/>
    <dbReference type="InParanoid" id="C7YVP3"/>
    <dbReference type="OMA" id="PEIAWEG"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000015">
        <property type="entry name" value="Tripeptidyl peptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF34">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE SED4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase S53" evidence="16">
        <location>
            <begin position="152"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="445"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="524"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="526"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEU44032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="546" mass="58757" checksum="B6C618ABDBE64816" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVV2</accession>
    <name>C7YVV2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WLM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_98512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU43853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049566.1">
        <property type="nucleotide sequence ID" value="XM_003049520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVV2"/>
    <dbReference type="STRING" id="660122.C7YVV2"/>
    <dbReference type="MEROPS" id="M80.A04"/>
    <dbReference type="GeneID" id="9677141"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_98512"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98512"/>
    <dbReference type="eggNOG" id="KOG4842">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056790_0_0_1"/>
    <dbReference type="InParanoid" id="C7YVV2"/>
    <dbReference type="OMA" id="GMQKHPF"/>
    <dbReference type="OrthoDB" id="49605at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
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        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47795:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47795">
        <property type="entry name" value="UBIQUITIN AND WLM DOMAIN-CONTAINING METALLOPROTEASE SPCC1442.07C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WLM" evidence="2">
        <location>
            <begin position="127"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU43853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="352" mass="39475" checksum="4866EE0D99670E1C" modified="2009-10-13" version="1">MANSPMADDASTSESAWLTLSVKHRQIIYDLSFPEDATVTDLFHEIEASLNIPVANQKILAPKCPLLKFPPKNPDMPLLDLKGKPLTLMGAPAAEVQQIQDMAERVAKRNAARMAQRSRARHAPTRKTAEDSQYTFLQVRPLQGLPNPDRSQKLLLRLKEDPGIRAAMKKHKFTVGLLTEMEPLSHTQTTHEGTSRILGLNRNQGEVIELRLRTDAHDGYRDYKTIRKTLCHELAHNVHSPHDRNFWDLCHQIEREVQAADWKSGGHTIGETSRYTISGVDEEEFEEDHGGWTGGEFVLGGASNAATAGLSRREVLAQAALERQRKEVEAERKVLEAAEKTRRHTPPGDDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7YW25</accession>
    <name>C7YW25_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SDA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_56912</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for 60S pre-ribosomal subunits export to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SDA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU43892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049605.1">
        <property type="nucleotide sequence ID" value="XM_003049559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YW25"/>
    <dbReference type="FunCoup" id="C7YW25">
        <property type="interactions" value="1131"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YW25"/>
    <dbReference type="GeneID" id="9677180"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_56912"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_56912"/>
    <dbReference type="eggNOG" id="KOG2229">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009161_2_1_1"/>
    <dbReference type="InParanoid" id="C7YW25"/>
    <dbReference type="OMA" id="AMYKTYK"/>
    <dbReference type="OrthoDB" id="2196187at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007089">
        <property type="term" value="P:traversing start control point of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027312">
        <property type="entry name" value="Sda1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048292">
        <property type="entry name" value="SDA1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007949">
        <property type="entry name" value="SDA1_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012977">
        <property type="entry name" value="SDA1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730">
        <property type="entry name" value="HSDA/SDA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730:SF0">
        <property type="entry name" value="PROTEIN SDA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21638">
        <property type="entry name" value="SDA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05285">
        <property type="entry name" value="SDA1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08158">
        <property type="entry name" value="SDA1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SDA1 N-terminal" evidence="9">
        <location>
            <begin position="70"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 middle" evidence="8">
        <location>
            <begin position="535"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 C-terminal" evidence="10">
        <location>
            <begin position="688"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="509"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="617"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="570"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="628"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="653"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="675"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="715"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU43892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="740" mass="83885" checksum="341C34CD1391C83F" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWF5</accession>
    <name>C7YWF5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pentatricopeptide repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_74284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU43950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049663.1">
        <property type="nucleotide sequence ID" value="XM_003049617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWF5"/>
    <dbReference type="STRING" id="660122.C7YWF5"/>
    <dbReference type="GeneID" id="9677483"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74284"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74284"/>
    <dbReference type="eggNOG" id="ENOG502SDIM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_390868_0_0_1"/>
    <dbReference type="InParanoid" id="C7YWF5"/>
    <dbReference type="OMA" id="HRCGCRA"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="61"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU43950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="721" mass="82241" checksum="D690AC86883AE882" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWI1</accession>
    <name>C7YWI1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase II subunit RPB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_30000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049900.1">
        <property type="nucleotide sequence ID" value="XM_003049854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWI1"/>
    <dbReference type="FunCoup" id="C7YWI1">
        <property type="interactions" value="985"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YWI1"/>
    <dbReference type="GeneID" id="9677249"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_30000"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_30000"/>
    <dbReference type="eggNOG" id="KOG1522">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038421_1_1_1"/>
    <dbReference type="InParanoid" id="C7YWI1"/>
    <dbReference type="OMA" id="FYFEVES"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07031">
        <property type="entry name" value="RNAP_II_RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="9">
        <location>
            <begin position="26"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="276"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU44187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="335" mass="37176" checksum="DEA9BFDB48273D03" modified="2009-10-13" version="1">MDYDPMVMDGEPEQPQVKISAADHTHVDFELSKTNLAFANALRRVIQAEVPTIAIDLVEIEINSSVLADEFIAHRLGLIPLDSKGVGELNNSRDCDCEQYCEQCSVTLNLHAKCTSDEIMKVYARDLVVDGRHANSVGSPVITDPEGYGCLIAKLRKDQELKITCIAKKGIAKEHAKWMPTSAVGFEYDPHNKLHHLDMWFENDTDPEVEWPKSKYAQWEDPPQEGEPFDYDAVPNRFYFEVETSGSMEPDQIVQSGIRVLQQKIGGLLKGLDPRKYGGDEAEFDGPRSPDMNMDGGTTPWQDGGYTTPYGGNATAYGGGMTAYGTTPYGQSSWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXQ5</accession>
    <name>C7YXQ5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_82612</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049098.1">
        <property type="nucleotide sequence ID" value="XM_003049052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXQ5"/>
    <dbReference type="ESTHER" id="nech7-c7yxq5">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="9666396"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82612"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82612"/>
    <dbReference type="eggNOG" id="KOG1516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_14_4_1"/>
    <dbReference type="InParanoid" id="C7YXQ5"/>
    <dbReference type="OMA" id="SWPQFDY"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="19"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU43385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="552" mass="60296" checksum="AC3BA6F503FF5032" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXT0</accession>
    <name>C7YXT0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_101086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049352.1">
        <property type="nucleotide sequence ID" value="XM_003049306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXT0"/>
    <dbReference type="GeneID" id="9677003"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101086"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101086"/>
    <dbReference type="eggNOG" id="ENOG502QQYU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058489_0_0_1"/>
    <dbReference type="InParanoid" id="C7YXT0"/>
    <dbReference type="OMA" id="RPYHAAG"/>
    <dbReference type="OrthoDB" id="1523883at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.270">
        <property type="entry name" value="Methyltransferase, alpha-helical capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005299">
        <property type="entry name" value="MeTrfase_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042086">
        <property type="entry name" value="MeTrfase_capping"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31009">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE:CARBOXYL METHYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03492">
        <property type="entry name" value="Methyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU43639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="361" mass="40170" checksum="6605B98518E4B5C8" modified="2009-10-13" version="1">MTDTAHINDVPMQGKGLYSSHAALQHEAMLKALPLLTQATNTVVTNVNRNSRPITVVEYGSAHGNNSIQPMVTILGSTPPGDIQLIFSDRPENDFNTLSTTVTTWAEGLDKAKFSHSIFPAMIPRSFYHQVVPSRSANLGFSLAALHHLDHVPKGEDGVDHQALLKRQAHLDLLRFLKLRADEIVPGGSLVLSFVSQSSSGRENYAGLVDACRSAMIDMVKDGTLLGAVAGSFYVPTYNRTLQDVQKVIEEMIPTWIAHEVFEQECLHPAKKDLELQKSSDGQNSNDASHRYADIVVDWLMAVCAGYFLKAVKVGSDNTFTHEDAEKFLVDWVKRTKEFFFKDHRDEDVVCSFIFVRLERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXT2</accession>
    <name>C7YXT2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_45085</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049354.1">
        <property type="nucleotide sequence ID" value="XM_003049308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXT2"/>
    <dbReference type="STRING" id="660122.C7YXT2"/>
    <dbReference type="GeneID" id="9666410"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45085"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45085"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_1"/>
    <dbReference type="InParanoid" id="C7YXT2"/>
    <dbReference type="OMA" id="LWTDEVF"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07106">
        <property type="entry name" value="ALDH_AldA-AAD23400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044086">
        <property type="entry name" value="LUC3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU43641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="462" mass="49514" checksum="25830D37A8C1B279" modified="2009-10-13" version="1">MDFSTFHNIIGGKPRGSDNSHSGVDPLTRTPLWPVPTASPQDVDDAVEAAQRALPTWSKTSYDERIGLLERFADLYLSRAGEFCKLLASECGRTVSVITESARDALNWSLYKLSEEQVEDDTKTAIVTYEPLGVVAAICPWNFPLMLAIGKIAPALATGNCVILKPSPFTPYTSLKLVELAQEVFPPSVIQVLSGENDLGPALVRHPGIQKISFTGSTATGKQILKDGADTMKRITLETAGNNPAIILPDINVTATVPHISGGLWFNAGQVCIAPRRLYIHADIFDAFVDALVETTKEATKEMTKIGPVQNELQFRKLVKTLDDAKSAGHDMATGGPLAESETGGFFLRPTIIKDASPESSIVSGEHFGPIVTCVRFSDADEAVRLANAGESGLAASIWTTDSTAAKALASRLDVGSVYINGPPQPDPRVPFGGHKQSGLGVEYGLQGLLSFCQTKAVYLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7YY19</accession>
    <name>C7YY19_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_16178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049147.1">
        <property type="nucleotide sequence ID" value="XM_003049101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YY19"/>
    <dbReference type="STRING" id="660122.C7YY19"/>
    <dbReference type="GeneID" id="9666536"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_16178"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_16178"/>
    <dbReference type="eggNOG" id="KOG1371">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_10_1"/>
    <dbReference type="InParanoid" id="C7YY19"/>
    <dbReference type="OMA" id="CVILRYF"/>
    <dbReference type="OrthoDB" id="9402762at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005996">
        <property type="term" value="P:monosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000418">
        <property type="entry name" value="UDP-glucose 4-epimerase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF3">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU43434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="380" mass="41964" checksum="FF1BACBA13B6B49A" modified="2009-10-13" version="1" fragment="single">FILVTGGLGFIGSHTTLELLKVGYNVIIVDDLSNSYHGVFSRIRILAEKYCEEQGRKMPALHFHKLDYRSKAMQFLLESYSTLVPVSDDTTGESIRRESRVAGVIHFAAFKSVSESIERPFQYYRNNVCGLVDFVELLGKHNIRKFVFSSSATVYGTKAEEGRPLQEEDLVHHSTTYQDEMGNQRVAEPVVSGLQSPYARSKYFCEAILADIAHADPSWRIVALRYFNPIGCHPSGLLGEDPKGIPTNLFPVITQVLTGERAQLDIFGTDWETRDGTAIRDFIHVADLARGHAAALGAEISAPFRTFNLGTGTGTTVAEALQSLEAASSRRIPVKLAPRRGGDVGFCVAANDRAASELNWTAQESIQQCASDLWNFVTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYR4</accession>
    <name>C7YYR4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cell division control protein 48</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_71084</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048760.1">
        <property type="nucleotide sequence ID" value="XM_003048714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYR4"/>
    <dbReference type="FunCoup" id="C7YYR4">
        <property type="interactions" value="1319"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YYR4"/>
    <dbReference type="GeneID" id="9665532"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_71084"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_71084"/>
    <dbReference type="eggNOG" id="KOG0730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_12_0_1"/>
    <dbReference type="InParanoid" id="C7YYR4"/>
    <dbReference type="OMA" id="VWPAYPE"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19519">
        <property type="entry name" value="RecA-like_CDC48_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19528">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000004">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000001">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000003">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000048">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="7">
        <location>
            <begin position="42"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48" evidence="6">
        <location>
            <begin position="142"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="254"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="528"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="794"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU43047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="820" mass="90105" checksum="F62D531DC6B61ACA" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZD6</accession>
    <name>C7YZD6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_83993</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048499.1">
        <property type="nucleotide sequence ID" value="XM_003048453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZD6"/>
    <dbReference type="GeneID" id="9667576"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83993"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83993"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035052_0_0_1"/>
    <dbReference type="InParanoid" id="C7YZD6"/>
    <dbReference type="OMA" id="GLQWGST"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF47">
        <property type="entry name" value="ENDOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01220)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988685" description="Peptidase A1 domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="105"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU42786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="452" mass="49632" checksum="071561F3C89519BD" modified="2009-10-13" version="1">MAWIYRFLLFISTLAFHVLAAAVETEPDKADLDLTTPWNGFHLKRAVPIVARSPDVLSTRVSKLKKLNRKHQLHPRSAASLLAKRNEGPFSLKKGIQNISAVGDFSTSYAIECVWDSTPVWLTFDTASSDTWAVKSGFRCENNLGDKQDQDWCGFGQPHIKDFGLGSLTEIHLHRSYASGENVSGPMGVSDITCGDVAVHNQQVGLVNRTYWHGDNVTVGVLGLAYPSLTSGYLGGPKDETEWNNYPYTPWLTKAIAQGETSPMFSVWLDRNSSDGMLTWGGLPRPAASKLGQLTTTGLIIAKLDDREKTAWKPSFYTIIPDGLRWGSRTDTGKYPYIVDTATTMIHVPPPLAEAIAAAFEPQAVYLYQWGSYFVPCDSIAPSFAITISGLNLWVNPADMIFKDLVDPGTGYCATAITTGGSGPYILGDVFLQNVLAVFDVGNAEMRFYARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZL8</accession>
    <name>C7YZL8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_84073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048537.1">
        <property type="nucleotide sequence ID" value="XM_003048491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZL8"/>
    <dbReference type="GeneID" id="9667418"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84073"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84073"/>
    <dbReference type="HOGENOM" id="CLU_742047_0_0_1"/>
    <dbReference type="InParanoid" id="C7YZL8"/>
    <dbReference type="OrthoDB" id="5096971at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="373" mass="39976" checksum="E9DAEC1CC674E335" modified="2009-10-13" version="1">MEVANAIILFDSVDQGNLSSPASYPRLTLSVVPQRSRDQVRARLQITLVGLLATATAGYITAVGRSAIWSWEETNSGKRILDWQGGIDHYIIEAGVLGAGIDEGKGLCGEEERLIQKAIQGQGAEASEQLDKDNTTGDKDPGVDKDPGVDKDLGVDKDLGVDKDLRGDERQTVVKSNGLRTTPACSVRCEGTVGSVIFTATNGQAKLIICNQRSLRSSRSGRSSPRGPRGLRLPLHCPVPLPSPLSFQRPKSSTFTGHITPSWRQPFSLLVNCYLPVLDSSAGQYRLPLMTVDSSPTETGRVHDNLPAGRDFSMLLPFIYDTSSFSDRQVQVANAGTIVASTVVEGQAPARRHTSINAADPAMGKKGGKAVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZS7</accession>
    <name>C7YZS7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_84131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048564.1">
        <property type="nucleotide sequence ID" value="XM_003048518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZS7"/>
    <dbReference type="GeneID" id="9667450"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84131"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84131"/>
    <dbReference type="eggNOG" id="ENOG502TD9H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_912443_0_0_1"/>
    <dbReference type="InParanoid" id="C7YZS7"/>
    <dbReference type="OrthoDB" id="5431013at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU42851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="33921" checksum="32806CD34C2C5921" modified="2009-10-13" version="1">MAEPLAVVGVVASLVQLTDASIRTCLCLYGFFLGLRNSQPEFHRHATVIRDVHDAIQSIRGTVVSQNLSEAEKKGLVSHLNSMDQELSTLEKETAAKDPAKLKARIILALKSAETERALQRLENHKTTLLLYLQALSFNRAEKILCSQNSAEARLQSLIEQQDRHESAIRSDIENGIEDLSEKMGILDSAVGISQECLREGFFTISREIQVSGEHLRSIFRQELQRQLQPLVEEAMTRSEMRRAATPRQLCLDVGAATTSVTTVRVIRGRDVPGLLLSRIDRTDIVHFFGWVAVGYVGTMAAAMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZV7</accession>
    <name>C7YZV7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_95819</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048389.1">
        <property type="nucleotide sequence ID" value="XM_003048343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZV7"/>
    <dbReference type="STRING" id="660122.C7YZV7"/>
    <dbReference type="GeneID" id="9667466"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95819"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95819"/>
    <dbReference type="eggNOG" id="ENOG502STRK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031300_0_0_1"/>
    <dbReference type="InParanoid" id="C7YZV7"/>
    <dbReference type="OMA" id="FPIDEMF"/>
    <dbReference type="OrthoDB" id="4330117at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="49"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="186"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU42676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="448" mass="49868" checksum="30F71C82BA2EFF69" modified="2009-10-13" version="1">MAETVIRKACDRCHAQKLSCKRYNDEPCERCVRLKTECKSSPSLRYRKQQQQQQLVDNNSNHLQGQQLSTSSTPAPTGRRSPKRRRTDSQGDASLVPPDAVCPSESTDSLPLCRKAVPISHVPVTPDPVLDAGDFGFTFDQLAFFPQHLSHPELPGGVVVNDPHLVHHPPANVFADSWNPRLALQQQPLRSRSCVPEHGSSDKRSRPRTKQRPRQITLRHDADHLSPLHPEAPPIHWMAQLSDINARLLDLASALPSPQEVAQNGPSLGRPVDERFRSQGFPIEDMFKLTRRVADILEKPPTDTPDRDGVRGHHSTIDGTDPGNAMFILSTYVRLLDMYQRVFSLVHAELSRADSGATFSFWKLPAVTVGSFAVESSPFLQMSLTIQLAEEFLCRLRGSTARWSGAGNAASMFAGVVDVSFQAFRDREEALAKHLVELRSEIEPLLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z088</accession>
    <name>C7Z088_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_63227</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048457.1">
        <property type="nucleotide sequence ID" value="XM_003048411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z088"/>
    <dbReference type="GeneID" id="9667534"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_63227"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_63227"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_0_1"/>
    <dbReference type="InParanoid" id="C7Z088"/>
    <dbReference type="OMA" id="FTVQYWN"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF12">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="471"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="71"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU42744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="574" mass="62989" checksum="7B4B2FE6F0AE1E69" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0F0</accession>
    <name>C7Z0F0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_79869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048084.1">
        <property type="nucleotide sequence ID" value="XM_003048038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0F0"/>
    <dbReference type="GeneID" id="9671888"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79869"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79869"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038958_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z0F0"/>
    <dbReference type="OMA" id="AYPECHA"/>
    <dbReference type="OrthoDB" id="5062850at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU42371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="528" mass="61527" checksum="EC7FA3F45C658D20" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0J9</accession>
    <name>C7Z0J9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_68927</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047931.1">
        <property type="nucleotide sequence ID" value="XM_003047885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0J9"/>
    <dbReference type="FunCoup" id="C7Z0J9">
        <property type="interactions" value="1099"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z0J9"/>
    <dbReference type="GeneID" id="9667277"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_68927"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_68927"/>
    <dbReference type="eggNOG" id="KOG0004">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010412_2_0_1"/>
    <dbReference type="InParanoid" id="C7Z0J9"/>
    <dbReference type="OMA" id="GVFMAFH"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000008">
        <property type="entry name" value="Ubiquitin-40S ribosomal protein S27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_eS31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038582">
        <property type="entry name" value="Ribosomal_eS31_euk-type_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU42218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="153" mass="17611" checksum="CA0CB310C80DC077" modified="2009-10-13" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGAKKRKKKVYTTPKKIKHKRKKTKLAVLKYYKVDSDGKIERLRRECPSDTCGAGVFMAAMQDRQYCGRCHLTYVFDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z131</accession>
    <name>C7Z131_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NECHADRAFT_69103</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048007.1">
        <property type="nucleotide sequence ID" value="XM_003047961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z131"/>
    <dbReference type="FunCoup" id="C7Z131">
        <property type="interactions" value="451"/>
    </dbReference>
    <dbReference type="MEROPS" id="A01.018"/>
    <dbReference type="GeneID" id="9671992"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_69103"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_69103"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_3_4_1"/>
    <dbReference type="InParanoid" id="C7Z131"/>
    <dbReference type="OMA" id="KYDHDAS"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097718">
        <property type="term" value="F:disordered domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070492">
        <property type="term" value="F:oligosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016237">
        <property type="term" value="P:microautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000036">
        <property type="entry name" value="Vacuolar aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000002">
        <property type="entry name" value="Vacuolar aspartic proteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988729" description="Peptidase A1 domain-containing protein" evidence="13">
        <location>
            <begin position="18"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="14">
        <location>
            <begin position="86"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="117"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU42294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="396" mass="42876" checksum="F9E52722091248CF" modified="2009-10-13" version="1">MKSALLAAAALLGSAQAGVHKMKIQKVPLAEQLATTSIETHIQNLGQKYLGSARPKNQADYAFSTEAINVEGGHPVPISNFMNAQYFSEITIGNPPQSFKVVLDTGSSNLWVPSQECGSIACYLHSKYDSSASSTYKQNGSEFEIHYGSGSLSGFISNDDVSIGDLKIKGQDFAEATKEPGLAFAFGRFDGILGLGYDTISVNHIVPPFYQMVNQKLLDDPVFAFYLADQEGESEVVFGGVDKSHYEGDIEYIPLRRKAYWEVDLDAIALGDEVAEQENTGAILDTGTSLNVLPSALAELLNKEIGAKKGYNGQYTVECDKRQTLPDITFTLAGSNYSLPATDYILEVSGSCISTFQGMDFPEPVGPLVILGDAFLRRYYSVYDLGKNAVGLARSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1E7</accession>
    <name>C7Z1E7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_97011</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU41990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047703.1">
        <property type="nucleotide sequence ID" value="XM_003047657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1E7"/>
    <dbReference type="STRING" id="660122.C7Z1E7"/>
    <dbReference type="GeneID" id="9671657"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_97011"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_97011"/>
    <dbReference type="eggNOG" id="ENOG502RMIF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096868_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z1E7"/>
    <dbReference type="OMA" id="QNDSTWE"/>
    <dbReference type="OrthoDB" id="433924at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="156"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU41990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="241" mass="27025" checksum="05FE07D5E7645D8D" modified="2009-10-13" version="1">MATDTPSKDGDVVNARDKAVDGHKAGTPRGTPRATPKIATPANDEKPDRSTPAAAEPTEPKSIDKRNGDKDAQVNGDAPAASADKPAEFRDDVEIDEFIDHRVDEATSTVDIQVKWEGGETTWETEWSLQEQVPTLVFKYWDKLEGRDAVTNLDIYHVFKILKRTSLPGKSKKPQYMYQVQWVGYRRTDSTWEHEDKLREIAPAELEKFEAKELANGTGPQKRKNARGPGRPRKRARADSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z205</accession>
    <name>C7Z205_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_51095</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU42090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047803.1">
        <property type="nucleotide sequence ID" value="XM_003047757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z205"/>
    <dbReference type="GeneID" id="9671588"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51095"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51095"/>
    <dbReference type="eggNOG" id="ENOG502QRQD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027816_0_1_1"/>
    <dbReference type="InParanoid" id="C7Z205"/>
    <dbReference type="OMA" id="DIGQMIW"/>
    <dbReference type="OrthoDB" id="294730at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF20">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="76"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU42090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="506" mass="56780" checksum="60FF6027EB7D0D0F" modified="2009-10-13" version="1">MSSRPIHPDLENASPPRSSSWLASAFGGRNLVIGPRIEPLPNDNLPKTIHDSDSQTADLVDTQSDSEVGNTIQYRTCSWQKTAGLLFSEYIVLSIMSFPWSYSLLGLVPGLILTAVIAGVVLYTSLILWEFCLRHPEVRDICDIGQILFWDKKWAWWCTAVMFTLNNTFIQALHILVGAIYLNTMTVSDPIRACRTVAFAIVVTSISWLGSLPRTFDMMAKIGAISTFFTFISVILATAFTAAQGEPAGYPSLGEPIISIWTPKTTTLVTGMSAFLNISFTFMGQLTLPSFIAEMREPRDFPKALWVCTIAEIITFSVVGTVIYVYTGNQYMVTPAFGALETVYKKVSYSFMVPTIVFVGCLYASVTGRFIFFRMFQDSRHLTEHTFKGWFWWVFVLLMTWVFAFLISGIIPFFESLLSVMASLFNCWFGFIFWGLAYFRMRNADQRVGKARKSLLDYMSIVLNVTLILIGFLYLTLGTYVSVQGIIDQFKEGNVSGVFSCRSNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z2L3</accession>
    <name>C7Z2L3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycoside hydrolase family 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_53871</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047209.1">
        <property type="nucleotide sequence ID" value="XM_003047163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z2L3"/>
    <dbReference type="STRING" id="660122.C7Z2L3"/>
    <dbReference type="GeneID" id="9676051"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_53871"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_53871"/>
    <dbReference type="eggNOG" id="KOG1066">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000631_7_3_1"/>
    <dbReference type="InParanoid" id="C7Z2L3"/>
    <dbReference type="OMA" id="HQGEWSF"/>
    <dbReference type="OrthoDB" id="10070917at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06591">
        <property type="entry name" value="GH31_xylosidase_XylS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051816">
        <property type="entry name" value="Glycosyl_Hydrolase_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43863">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43863:SF2">
        <property type="entry name" value="MALTASE-GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="4">
        <location>
            <begin position="251"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="5">
        <location>
            <begin position="598"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU41496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="681" mass="77371" checksum="CFAD1630394E8E52" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z3H7</accession>
    <name>C7Z3H7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_83253</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046851.1">
        <property type="nucleotide sequence ID" value="XM_003046805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z3H7"/>
    <dbReference type="GeneID" id="9675764"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83253"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83253"/>
    <dbReference type="eggNOG" id="ENOG502RZ2S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006926_1_1_1"/>
    <dbReference type="InParanoid" id="C7Z3H7"/>
    <dbReference type="OMA" id="IVETECW"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU41138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="623" mass="69234" checksum="1C8B4B28E6CAAC42" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z3K2</accession>
    <name>C7Z3K2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_83278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046863.1">
        <property type="nucleotide sequence ID" value="XM_003046817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z3K2"/>
    <dbReference type="GeneID" id="9675759"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83278"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83278"/>
    <dbReference type="eggNOG" id="ENOG502RN9T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_763103_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z3K2"/>
    <dbReference type="OMA" id="ESSCANY"/>
    <dbReference type="OrthoDB" id="3766406at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU41150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="41624" checksum="68BA8D61B2A5BBF7" modified="2009-10-13" version="1">MSEEFTKISLEEVANEKIELIDERWQFQPATLTPTHWTPLTLQGLPRGVLIKIATYLNITNKACLAFTCQILCETCSKFHLPRRDRTWNKYEGPRRCIQYGNGRALEYLESPYLPRQVHFDIVAAITRSYRFDSGLYDTNSFFSTEKYTAGRAKITSNVSARLYKGSIVLKAELVLSAGKVAFASENVDKLEKMLQKSTKLENVCQHVKWAEVLPFIFRPQLPTVQKSGQSCLGKHSSQKCKISRQDLHTCLWTHSQKCWSRCDAYSRLGSDLQRLWSCNLCSTDYKISLSRKQGKSSETNSLVFTSWKNLGRCTSVYNEDWAGHMNPGLSDYQKRGTDLYDVARSFENPAKGLFDFEYYPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4D5</accession>
    <name>C7Z4D5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CT20 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_66483</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046616.1">
        <property type="nucleotide sequence ID" value="XM_003046570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4D5"/>
    <dbReference type="STRING" id="660122.C7Z4D5"/>
    <dbReference type="GeneID" id="9669027"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_66483"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_66483"/>
    <dbReference type="eggNOG" id="KOG4051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050564_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z4D5"/>
    <dbReference type="OMA" id="QHTRIPY"/>
    <dbReference type="OrthoDB" id="5595141at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012423">
        <property type="entry name" value="Eaf7/MRGBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581">
        <property type="entry name" value="MRG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581:SF5">
        <property type="entry name" value="MRG_MORF4L-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07904">
        <property type="entry name" value="Eaf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="151"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU40903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="31775" checksum="A350502E3F2666AF" modified="2009-10-13" version="1">MAPRKRARASTQTAATPTPARDDDAMDVDTPQAGDQEEAAEQKEPDNNFNDHWTDDQVASLFKGVIRWKPAGMHRHFRMIAISEHLRNHGFDPDLYPHTRIPYIWQKLRTYYNLEVIDERENFDEDETEDRYVEFSLPRAQFFDAMMQRAVADPSEAPTSPAQLDLSPAPSSPAKKRKRGDTKTRGTSVEDTEEGTDAPSPAPKTKRGSRQKKKGATQTKAEKQEKAETTEEEEAEEGSSSSSSEEEEGSADEGGTPVSKATRGAKKGQKSAPAKTRARARRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4I0</accession>
    <name>C7Z4I0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_76528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046063.1">
        <property type="nucleotide sequence ID" value="XM_003046017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4I0"/>
    <dbReference type="GeneID" id="9668501"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76528"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76528"/>
    <dbReference type="eggNOG" id="ENOG502SUCX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162804_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z4I0"/>
    <dbReference type="OMA" id="IRGDICI"/>
    <dbReference type="OrthoDB" id="2279190at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU40350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="124" mass="12281" checksum="B57BFDFACF6CBE15" modified="2009-10-13" version="1">MSAPTSTPPPASDSPIAQPPSPAPAPAAPAPAPAAPTLAKPAYASDSDSDGQARGGRRGPKQQFVVPLPTSTGLSQPAGQLLKGATDDAGAQKSAALLVGIKLDLEAEVHLTARVKGDIVVGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z5P6</accession>
    <name>C7Z5P6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCT-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_57766</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU39985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045698.1">
        <property type="nucleotide sequence ID" value="XM_003045652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z5P6"/>
    <dbReference type="FunCoup" id="C7Z5P6">
        <property type="interactions" value="1404"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z5P6"/>
    <dbReference type="GeneID" id="9678381"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_57766"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_57766"/>
    <dbReference type="eggNOG" id="KOG0363">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_6_2_1"/>
    <dbReference type="InParanoid" id="C7Z5P6"/>
    <dbReference type="OMA" id="CAEMVMS"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03336">
        <property type="entry name" value="TCP1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000002">
        <property type="entry name" value="T-complex protein 1 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012716">
        <property type="entry name" value="Chap_CCT_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02341">
        <property type="entry name" value="chap_CCT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU39985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="528" mass="56882" checksum="6F27F047F1482CEE" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z677</accession>
    <name>C7Z677_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_76006</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045793.1">
        <property type="nucleotide sequence ID" value="XM_003045747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z677"/>
    <dbReference type="STRING" id="660122.C7Z677"/>
    <dbReference type="GeneID" id="9668552"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76006"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76006"/>
    <dbReference type="eggNOG" id="ENOG502QR47">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004835_2_0_1"/>
    <dbReference type="InParanoid" id="C7Z677"/>
    <dbReference type="OMA" id="GMECNYP"/>
    <dbReference type="OrthoDB" id="4356994at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="30"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="133"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU40080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="673" mass="76285" checksum="0C98777E846A234F" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6H5</accession>
    <name>C7Z6H5_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_76103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046408.1">
        <property type="nucleotide sequence ID" value="XM_003046362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6H5"/>
    <dbReference type="STRING" id="660122.C7Z6H5"/>
    <dbReference type="GeneID" id="9667968"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76103"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76103"/>
    <dbReference type="eggNOG" id="ENOG502T1T9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_924663_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z6H5"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU40695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="301" mass="34235" checksum="D7E6701A4065BFBE" modified="2009-10-13" version="1">MGSQGSYSTVRRTPVPEEIRLEIEDSYRRSPTARQIIDLLERNYGLKLEDNPIFGTSTVDTTIAELVRAILRIEWNTLSGAASDPPRDASNLAAICPLSRYGLDSTISGASPRKLTPPTTEWGRIATDDGTTNRAVHVIYRKMLTYRLTQSNPTLKEVALNQAYFTLKDVESDRPLRDFSARIFDVSRVVGKATDLELLTRFYAKLHPELRQLYRAPVESDERSKYINMVDSKRKTLREKLKAARNGKTGNGAKKLQYGEKHAYTTNERDNKGSEPEDSALWGNDRPWNRGYRDRNRPPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6Q7</accession>
    <name>C7Z6Q7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_32323</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EIF1AD family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045887.1">
        <property type="nucleotide sequence ID" value="XM_003045841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6Q7"/>
    <dbReference type="STRING" id="660122.C7Z6Q7"/>
    <dbReference type="GeneID" id="9668083"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_32323"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_32323"/>
    <dbReference type="eggNOG" id="KOG2925">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106477_4_0_1"/>
    <dbReference type="InParanoid" id="C7Z6Q7"/>
    <dbReference type="OMA" id="WRKQSYW"/>
    <dbReference type="OrthoDB" id="1738325at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039294">
        <property type="entry name" value="EIF1AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21641:SF0">
        <property type="entry name" value="RNA-BINDING PROTEIN EIF1AD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21641">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="3">
        <location>
            <begin position="25"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU40174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="104" mass="11999" checksum="686878DC5777496E" modified="2009-10-13" version="1">MGRPKRNVLAAAEESMTPPDVLGPGQSIVRVVKPEGNNLYTCELPDTKPLILELAQRFRNTIWIKRGGFVLAERYQESREDTRAMGEIVNVVRDEKLWRKQAYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6Z8</accession>
    <name>C7Z6Z8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_66258</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046497.1">
        <property type="nucleotide sequence ID" value="XM_003046451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6Z8"/>
    <dbReference type="FunCoup" id="C7Z6Z8">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="GeneID" id="9668838"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_66258"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_66258"/>
    <dbReference type="eggNOG" id="KOG0770">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_3_2_1"/>
    <dbReference type="InParanoid" id="C7Z6Z8"/>
    <dbReference type="OMA" id="FFGVYEF"/>
    <dbReference type="OrthoDB" id="415315at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000095">
        <property type="entry name" value="Mitochondrial carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="13"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="108"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="212"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="248"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="261"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU40784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="38484" checksum="773E27AFCB55A731" modified="2009-10-13" version="1">MTNQEDVEAEGRPPYLHAMIAGGIGGSTGDLLMHSLDTVKTRQQGDPHVPSKYTSLGQSYYTIWRQEGIRRGLYGGWIPALGGSFPGTVMFFGTYEWSKRFLIDHGVQQHLSYLSAGFLGDLAASIVYVPSEVLKTRLQLQGRYNNPHFISGYNYRGTLDAARTIVRSEGIPALFYGYKATLYRDLPFSALQFMFWEQFTTWARKYKQSRDIGVPLELLTGAAAGGLAGVITCPLDVVKTRLQTQVNTPAEARASKDHHASSQVRHISTSSPNTHRPRPGAIALETSSVFTGLRVIYRTEGVAGWFRGVGPRGVWTFIQSGCMLFLYQRILRQLEVLMPLEHEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z719</accession>
    <name>C7Z719_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Altered inheritance of mitochondria protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">AIM41</name>
        <name evidence="2" type="ORF">NECHADRAFT_33425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM41 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046505.1">
        <property type="nucleotide sequence ID" value="XM_003046459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z719"/>
    <dbReference type="FunCoup" id="C7Z719">
        <property type="interactions" value="102"/>
    </dbReference>
    <dbReference type="GeneID" id="9668215"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_33425"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_33425"/>
    <dbReference type="eggNOG" id="ENOG502SDB7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079430_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z719"/>
    <dbReference type="OMA" id="RWNSTGP"/>
    <dbReference type="OrthoDB" id="538640at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="entry name" value="Uncharacterised protein YqeY/AIM41 PF09424, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU40792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="195" mass="21015" checksum="4FF19C2D38DA2F34" modified="2009-10-13" version="1">MHLLRALRAFQPCSAYRQPANRLSSASLCRFYSTPAGDAPPPLLSKLKSELKTAMRAKDAPRLAVLRAIMSANLNASKTSTPIKTDVQLVALIRKIQKGAFDAVAEAKAAGREDLVQKEEEQIKVLDEYISNSGVQTLGEAELKALVQDAVEASKAAGIQAKAIMGDVMKRLSGALEGKDVDRKELAKLVKELTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z784</accession>
    <name>C7Z784_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">CPC2103</name>
        <name evidence="15" type="ORF">NECHADRAFT_90946</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC2 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="EEU40257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003045924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z784"/>
    <dbReference type="FunCoup" id="C7Z784">
        <property type="interactions" value="1062"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z784"/>
    <dbReference type="GeneID" id="9668252"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90946"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90946"/>
    <dbReference type="eggNOG" id="KOG0933">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001042_9_0_1"/>
    <dbReference type="InParanoid" id="C7Z784"/>
    <dbReference type="OMA" id="THNKIAM"/>
    <dbReference type="OrthoDB" id="10255539at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="ABC_SMC2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027120">
        <property type="entry name" value="Smc2_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="14">
        <location>
            <begin position="514"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="382"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="676"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="807"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU40257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1173" mass="131609" checksum="A25843FC2EC81C35" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7R0</accession>
    <name>C7Z7R0_FUSV7</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_39231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045583.1">
        <property type="nucleotide sequence ID" value="XM_003045537.1"/>
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    </dbReference>
    <dbReference type="GeneID" id="9672599"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_39231"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_39231"/>
    <dbReference type="eggNOG" id="ENOG502QUXN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019029_3_0_1"/>
    <dbReference type="InParanoid" id="C7Z7R0"/>
    <dbReference type="OMA" id="RITRIWY"/>
    <dbReference type="OrthoDB" id="10267139at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07187">
        <property type="entry name" value="YvcK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="entry name" value="CofD-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240:SF0">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CofD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="495" mass="53562" checksum="9C34992432E92C0C" modified="2009-10-13" version="1">MAQINIQQNGLGLQLPSSSGSSALTTPRRTATPNPGPPSGLVVFSGGSAANNLVDVFESVREANQCTLSYVIPISDNGGSSSEIIRVFGGPGIGDVRSRLVRLIPNDGSPETAAIKRFFNHRLPKAYTEARSEWFEILEATHSLWDDISSPKRELIRSYLNSFNLEVVKRMRPSSRFDFSGASIGNLFLTGARLFTGSFEAAIYLLSSICSVPDRIAVLPALNTNFASHIAAGLEDGTIITGQNDISHPSAPTAAVPGTSAGLHSPTVSRHEVWDHHHVEDANLPGTLPALRRPAIAFSKEQEEDLPARISRLWYINPYGEEIKMPANPRVLDALRSVHSIVYSIGSLFTSLIPSLVLRGVGDAIASPQIRNKILILNGTTDRETGPSTVPFTGLDFVRAIANACAESRGLLKIEQDEFSQYVTHVIYIEGPNSPKVDKQQFGLLGIDATRLYGPKDETGRGGKYDAKALTQALESIIGRKDARSDRSRRNTLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8P8</accession>
    <name>C7Z8P8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SRT2104</name>
        <name evidence="7" type="ORF">NECHADRAFT_81543</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045116.1">
        <property type="nucleotide sequence ID" value="XM_003045070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8P8"/>
    <dbReference type="FunCoup" id="C7Z8P8">
        <property type="interactions" value="85"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z8P8"/>
    <dbReference type="GeneID" id="9673202"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_81543"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_81543"/>
    <dbReference type="eggNOG" id="KOG2684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005935_0_1_1"/>
    <dbReference type="InParanoid" id="C7Z8P8"/>
    <dbReference type="OMA" id="FYTFATS"/>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF8">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="6">
        <location>
            <begin position="7"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="65"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="328"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="589"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="675"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="792"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="366"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="381"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="679"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="694"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="708"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="730"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="749"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="794"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU39403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1017" mass="110582" checksum="47CCCB3D345C0838" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8U9</accession>
    <name>C7Z8U9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_81637</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044748.1">
        <property type="nucleotide sequence ID" value="XM_003044702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8U9"/>
    <dbReference type="GeneID" id="9673324"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_81637"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_81637"/>
    <dbReference type="eggNOG" id="ENOG502S7CY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044876_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z8U9"/>
    <dbReference type="OMA" id="IGGWIPN"/>
    <dbReference type="OrthoDB" id="10000533at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="5"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU39035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="304" mass="33277" checksum="0018AAB9A7344DC0" modified="2009-10-13" version="1">MAVGAVAGGIGGVGKTMVSQLEFSKDHTVFVLSRTVPENQAPGTARVIKVDYNDTTSLTRCLEENKVEAVVSTINLQDEAASNAQLRLIEAADASKTTTKRFIPSEFAFANSPDGVEDEPSVRFAMESVDALRRSNLQFTRSANGFFMDYWGLPHIPSNLWTYTWAIDIANKRAAIPGTGDDLLSLTYSVDVAKFVVRMLESSDKWSETSILSGFDLTFHQLLAIAERIQGCKFDVKYDSLEALEKNEATLLQVGYGGGGWASEDEAKQMASLFGKMTISGTFRLPDDNRINDKFSGWVTPNDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8V7</accession>
    <name>C7Z8V7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Autophagy-related protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_81645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045166.1">
        <property type="nucleotide sequence ID" value="XM_003045120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8V7"/>
    <dbReference type="GeneID" id="9673663"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_81645"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_81645"/>
    <dbReference type="eggNOG" id="ENOG502RNMW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098352_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z8V7"/>
    <dbReference type="OMA" id="RMGIIAN"/>
    <dbReference type="OrthoDB" id="4750690at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045702">
        <property type="entry name" value="DUF6060"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19535">
        <property type="entry name" value="DUF6060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002987956" description="Autophagy-related protein 27" evidence="2">
        <location>
            <begin position="20"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU39453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="27376" checksum="36787EB159F65269" modified="2009-10-13" version="1">MKSIIGVALLSLFPTGALCLSKRSCTSFEPQGQYGNKGYTMPSPRTFRTSEYINCTTELARKEGNNEVCEVDRYTMGLTLNSTVNVSVSDIQPVLDAVKEAAASDTRAKINLNETVLTPYRVTKPGIPAGEAGYLAFTPIMRCWEGLLGDCSDDDEKLNGTTIEACGYEYEDHRAIGPDQLIVGKENVVQSNSDELKGKPQPTWEEVQEKAEKNKDDDKDNSASSLMGNVLGSGIWGCVVWTVIGTLWGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9B5</accession>
    <name>C7Z9B5_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_81695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045187.1">
        <property type="nucleotide sequence ID" value="XM_003045141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9B5"/>
    <dbReference type="STRING" id="660122.C7Z9B5"/>
    <dbReference type="GeneID" id="9673348"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_81695"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_81695"/>
    <dbReference type="eggNOG" id="ENOG502RQT6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045149_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z9B5"/>
    <dbReference type="OMA" id="NDSQDKA"/>
    <dbReference type="OrthoDB" id="4850022at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="478" mass="55249" checksum="5ADF3542D92B32C3" modified="2009-10-13" version="1">MSHGGHVPALPRPVASDKTSRDHEPPSFRTTHHEPDASHLTWDSHGSQLVVWGRHTHAATFVDFFFYLPCFAGSLCRQLCDLESLQLGDAVERRSDDDVAATHDSVSRIDPEIKQEVDDDKVDLGQLETRVEDKCQTTRASDVEEVGFEDRVNCDNEQDLDDGYDSDDEGHLCSLLLYFISKTVLHHLTESSKANNMDRFAEQFFGRPERDSNSRARPPENTSFMETFAKNLAKSAARSAAKRAMGESSGNRTRDRTRGGVGAGGVGEINLEDFRGLGSFVLGMLNGGNDDGRKGEERKKDKKRKRDRDRDRDGHRSRGFEDEGDRYASDKERRKKKRHRVTFAEPYYEFQGETYPPPYEPEPQYEPDPREHRRSSHRHHRRDSREREEREERRRRRRQRRYRRDLDLKTLKTELEAMSSTIISLNARGAKHRDCEFYDRFVRKGGRLQDVIGSTLGQIRGFEEGGGDDDRKRRHRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9L2</accession>
    <name>C7Z9L2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_43475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044831.1">
        <property type="nucleotide sequence ID" value="XM_003044785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9L2"/>
    <dbReference type="GeneID" id="9673472"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_43475"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_43475"/>
    <dbReference type="eggNOG" id="ENOG502QQ9Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006273_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z9L2"/>
    <dbReference type="OMA" id="ATIWIGE"/>
    <dbReference type="OrthoDB" id="10258955at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="3">
        <location>
            <begin position="356"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU39118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="960" mass="103508" checksum="401955A3639FC6F8" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9N5</accession>
    <name>C7Z9N5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_70366</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045245.1">
        <property type="nucleotide sequence ID" value="XM_003045199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9N5"/>
    <dbReference type="GeneID" id="9673830"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_70366"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_70366"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_11_5_1"/>
    <dbReference type="InParanoid" id="C7Z9N5"/>
    <dbReference type="OMA" id="RTGANWT"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000023">
        <property type="term" value="P:maltose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF5">
        <property type="entry name" value="ALPHA-GLUCOSIDES PERMEASE MPH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="88"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU39532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="590" mass="65969" checksum="2A0DD1CBE45EC3F1" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAB9</accession>
    <name>C7ZAB9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="18">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">NECHADRAFT_70548</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="function">
        <text evidence="17">This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="18"/>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044960.1">
        <property type="nucleotide sequence ID" value="XM_003044914.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="C7ZAB9">
        <property type="interactions" value="467"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZAB9"/>
    <dbReference type="GeneID" id="9672319"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_70548"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_70548"/>
    <dbReference type="eggNOG" id="KOG0204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_9_3_1"/>
    <dbReference type="InParanoid" id="C7ZAB9"/>
    <dbReference type="OMA" id="CFVLWFG"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000039">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 18" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 18" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1009"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1047"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1084"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1116"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="22">
        <location>
            <begin position="195"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="20">
        <location>
            <begin position="295"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="21">
        <location>
            <begin position="966"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="34"/>
            <end position="71"/>
        </location>
    </feature>
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            <begin position="158"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1220"/>
            <end position="1281"/>
        </location>
    </feature>
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        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="1220"/>
            <end position="1238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00059328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EEU39247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1281" mass="139593" checksum="51707D950094CF1D" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAF6</accession>
    <name>C7ZAF6_FUSV7</name>
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        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">NECHADRAFT_43678</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_43678"/>
    <dbReference type="eggNOG" id="ENOG502SJKS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008719_1_2_1"/>
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    <dbReference type="OrthoDB" id="4525710at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="564" mass="63914" checksum="BF23F960E7EDC47A" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBT8</accession>
    <name>C7ZBT8_FUSV7</name>
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        <recommendedName>
            <fullName evidence="4">Gag protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_88541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698916">
        <property type="protein sequence ID" value="EEU38468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044181.1">
        <property type="nucleotide sequence ID" value="XM_003044135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBT8"/>
    <dbReference type="STRING" id="660122.C7ZBT8"/>
    <dbReference type="GeneID" id="9670570"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88541"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88541"/>
    <dbReference type="HOGENOM" id="CLU_053170_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZBT8"/>
    <dbReference type="OMA" id="WITTWEM"/>
    <dbReference type="OrthoDB" id="5034228at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="338"/>
        </location>
    </feature>
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        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="45514" checksum="420F894E66D623EB" modified="2009-10-13" version="1">MTDNAVYYNDAKDWEDWQMEFRKRAEGEDVWQYIEPTSDLPWPQEPTPPNIADYQSNTIHANTESNSSGRSGRSQTTGSAVPQGLGDLSDAGRLSFQQHWNEYTVAIRRYETIKKSLRTLREWVLKTVNKSIQKTDLPPNGNLNKWYAILAQSGEEYASHRMEDARIAFKNHLRSAPKKEAGLEKWIVRWKELMAEGQRQGVPETTEPRAWALDFVNAVEETAPLWASNYRLNKLDAVNNREVSYREVATNLLREIANRRNRSAVPRGSYKAGFLTLHGKQADQDDTDQDDRDTQPPEPANLRGKAGSKGSSSGRGGKKTDQKRKRKESDAETESGRRCKACLAPGHSISSCFYVFPEKAPEGFRFNEAAARFVKIQIESDTAIKEEVNRLSKKAKLESDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCC8</accession>
    <name>C7ZCC8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_77006</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698918">
        <property type="protein sequence ID" value="EEU38237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043950.1">
        <property type="nucleotide sequence ID" value="XM_003043904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCC8"/>
    <dbReference type="GeneID" id="9670387"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77006"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77006"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022088_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZCC8"/>
    <dbReference type="OMA" id="GGAWKRW"/>
    <dbReference type="OrthoDB" id="4772757at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF48">
        <property type="entry name" value="PROTEIN VAPYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="104"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU38237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="466" mass="52267" checksum="71DC8B256F04A7F6" modified="2009-10-13" version="1">MSTTPPHESDLPVPTYSATDDGDLLNRIERATAVEFPILHSPIAKTTNLQRLTSDSDWTSYHEAYRLERDIVDSFFTSIENGHDDLVAEFISRGWVSPDTTSRVKETPLLAAVRAGKTPMVSRLVALGATVNAFGRPDTSKTLSDDERPERTPLMLAAERGHLALVKVLVKDYGADDGLVAPDGAIALRLAAINGHREIVDFLPSRRGGAWLRWKAAHHKQMERIRRAWNHIGGFLKVLFWDCPVLLFCEIPKELAKGIWKRRHRMAAACKRMAKELPAQIVKGVVELPGNIKRCGKAVWEGIKEIPPILKAIAVAIWKTIKEIPGAVMVFLKWIGRGFKRVGEAIIDVFSRLLSLLHTAIMAVVSFFKNITLQDIWDGFCSLVRAIFVDAPKAIGAFIKSFGQMTYDILKALFGTLGQCVWYLVTGILWLIQYVPHRIWTIFEALGTSIVRGYQEMMSYLNPKRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCW7</accession>
    <name>C7ZCW7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_122795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698919">
        <property type="protein sequence ID" value="EEU37990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043703.1">
        <property type="nucleotide sequence ID" value="XM_003043657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCW7"/>
    <dbReference type="GeneID" id="9670193"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_122795"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_122795"/>
    <dbReference type="eggNOG" id="ENOG502SZ09">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083066_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZCW7"/>
    <dbReference type="OMA" id="EHENGWT"/>
    <dbReference type="OrthoDB" id="5431298at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988723" description="Ubiquitin 3 binding protein But2 C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="21879" checksum="A8CABAB6C3D957E1" modified="2009-10-13" version="1">MPLINNIFTSLACLMAVTNAMPANIAARQPSNDECPSGSGQTVITPSAIYNIFPKHPEVAQPAVSGVRLESYDGASQVEQVVVFSGIPAGAKTCSFGWKQGEKLDRVFIVRGSDGVSDVRQLSGFPEGKDVTYNFIKPFDDAEKNVGGIDFANWDDLDAATHDAGGVDCAETLYFKVSLRNGDSGSKVYLGQDENNGYDVYYSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZD00</accession>
    <name>C7ZD00_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_84398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698919">
        <property type="protein sequence ID" value="EEU38133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043846.1">
        <property type="nucleotide sequence ID" value="XM_003043800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZD00"/>
    <dbReference type="GeneID" id="9670008"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84398"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84398"/>
    <dbReference type="eggNOG" id="ENOG502RKQX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082779_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZD00"/>
    <dbReference type="OrthoDB" id="5095207at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002989156" description="Ubiquitin 3 binding protein But2 C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU38133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="24777" checksum="CE89F61B6446A8BE" modified="2009-10-13" version="1">MHTSYLASAFVAVASLFSGSSAGLCRPSSSLLSSDTATVPSSTTEIASTTTDVTSSSNAASPTTTEVASTDVSSSTSDAPSSTSSLPEPITTFDLKGANSELEAVNGQSLSYRQQSGYSLFLVVPDSVADQYGPGEFHLEEGTNRLMVGDFHVFASSFSTSYSLTGYMQHIKSPYSVFISCVPPTARGQRLECMVEGTSRTEFKVALAEFTNGHSLYIYAPGLAPPTHVDVDMIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDD6</accession>
    <name>C7ZDD6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8004 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_63321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698919">
        <property type="protein sequence ID" value="EEU38081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043794.1">
        <property type="nucleotide sequence ID" value="XM_003043748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZDD6"/>
    <dbReference type="STRING" id="660122.C7ZDD6"/>
    <dbReference type="GeneID" id="9670156"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_63321"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_63321"/>
    <dbReference type="eggNOG" id="ENOG502RYFW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_702160_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZDD6"/>
    <dbReference type="OMA" id="HEAFAHA"/>
    <dbReference type="OrthoDB" id="5302380at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058317">
        <property type="entry name" value="DUF8004"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601">
        <property type="entry name" value="CHORIOGENIN HMINOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601:SF2">
        <property type="entry name" value="CHORIOGENIN HMINOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26013">
        <property type="entry name" value="DUF8004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8004" evidence="2">
        <location>
            <begin position="7"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU38081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="383" mass="43540" checksum="AFF968B913672577" modified="2009-10-13" version="1">MFLSVEMCKDYKSLTPISRALLEKASLEMQDRVNAAEERLVGFEYDDMWTHYGEAGQARGAAERLREMLYCHYQQVYGSWPPSPLARSRNQSVTSETSAEEDTWLTRSLVKALQKDFGALYDFLVNRDIIWDVSEARSGRKWMMVPENRSSMFEADTDEVPMTDMLIEFDNKHRFPHIPHPYPLLPESISPLEMPSRSKRSETPSGGRMGALERRVQLAYTESTNIFKLGSEFAANKLVEAFQRFEKSGRADDVDPARARRGRWVLIYGILQTLASVSVDDEMVVHTDRVEYHLSPRLSGAKIPPWKGGEGDRIGQGSHERSYCWVADEKWETDEDDEPREVRGWRGTGTAGDASPVLGGSLSPGPGTPWRRSPDRRGGREDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDI4</accession>
    <name>C7ZDI4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alginate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_54751</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043544.1">
        <property type="nucleotide sequence ID" value="XM_003043498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZDI4"/>
    <dbReference type="GeneID" id="9669862"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_54751"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_54751"/>
    <dbReference type="eggNOG" id="ENOG502QVUY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1202334_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZDI4"/>
    <dbReference type="OMA" id="VIGQMAW"/>
    <dbReference type="OrthoDB" id="5091525at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU37831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="25629" checksum="BC3F578F3AB3CFAA" modified="2009-10-13" version="1" fragment="single">GITKLLVDVFYEASERFLRTKNGQPPDHYWANWDLASLCNIHAIGVLSNNRSMIHRAVDYFKTANGMGAIENAIWKIHKEEGTGKDLGQNQEAGRDQGHATLVFAHLSVLAQQSYNQGEDLFALLENRILAGSEYMAKYNLGHDVPYSTYTNKHGTMTQTSDYGRGIVRPIGELLYGHYNGVKNLEAPWTRAYRDYVLENSGGAEGGGGDYGSTSGGYDQLGFGILLFRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDV9</accession>
    <name>C7ZDV9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Succinate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_64833</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>succinate semialdehyde + NAD(+) + H2O = succinate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13217"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 8">
            <text>succinate semialdehyde + NADP(+) + H2O = succinate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13213"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="8"/>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043588.1">
        <property type="nucleotide sequence ID" value="XM_003043542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZDV9"/>
    <dbReference type="STRING" id="660122.C7ZDV9"/>
    <dbReference type="GeneID" id="9669614"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_64833"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_64833"/>
    <dbReference type="eggNOG" id="KOG2451">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_5_4_1"/>
    <dbReference type="InParanoid" id="C7ZDV9"/>
    <dbReference type="OMA" id="FMEAKYI"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="UniPathway" id="UPA00733"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036243">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000005">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010102">
        <property type="entry name" value="Succ_semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01780">
        <property type="entry name" value="SSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF11">
        <property type="entry name" value="SUCCINATE SEMIALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU37875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="502" mass="53865" checksum="D6DE6F4D25F6C221" modified="2009-10-13" version="1">MPYSAPKLKDPSLFVGKNYVDGQWIESVSGKRFDVHDPASGALIGSCPESVAQDAEQAIKIAAAALPEWRSRTGRNRSRILRRWYELVIENKEDLATLITWENGKAGPDAAGEVLFAASFLEWFAEEAPRVYGDVIPHSAPGFRVSVIKEPVGVVGLITPWNFPAAMITRKLGPALAAGCTAVVKTAGETPFTANALLVLGERAGVPKGVINSIAALENTPEIGQTLCASDVVRKISFTGSTRVGKILMNQSSDTLKKLSLELGGNAPFIVFDDADLDLAIAGAIASKFKCSGQTCVCSNRIFVQKGIYSQFVEKLKAVVSKFQVGHGFDSKTTHGPLVTAAAAERVDDLVKEAVKAGAKVEVGGKRRTDLGKSRPNFFEPTILTNVTTDMRLVRDEIFGPLAPIFSFDNEDEVVDIANKCDVGLASYIFTQDVNRVARVTELLHFGMVAVNTGIMSDAAAPFGGVKHSGMGREGSKYGIEDYLHVKTIVTGNVNVVHRALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEQ8</accession>
    <name>C7ZEQ8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_86311</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043084.1">
        <property type="nucleotide sequence ID" value="XM_003043038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEQ8"/>
    <dbReference type="STRING" id="660122.C7ZEQ8"/>
    <dbReference type="GeneID" id="9665281"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86311"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86311"/>
    <dbReference type="eggNOG" id="KOG0256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_1_2_1"/>
    <dbReference type="InParanoid" id="C7ZEQ8"/>
    <dbReference type="OMA" id="NPQGRCY"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF39">
        <property type="entry name" value="AMINOTRANSFERASE CLASS I_CLASSII DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="50"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU37371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="449" mass="49827" checksum="9F2C496F78F5466C" modified="2009-10-13" version="1">MAQNFPPSARASATLDQGPAWTLMQRVKSRPKYDSQNKPDGLINLSGALNGLMEDWMKAYADKNLHFTSEALSYGPLSGSQDLLSAAAAFFNRFFDPAEPVAAEQVLAANGVTSLLNMMAWTLCDEGDGALYTTPRFYMLDFDLSVRTGLATVPVSMTGLKDPFGADGLDEFIEALEAAADNAQDKLNVKCRMLCLTNPSNPQGRWYSKETLEALASWCAQRQMHLVVDEIYALSTFSNEDDHNNPNGDNLVPMTSILSVSARENVHCLYGLSKDFNMGGVRMAFLVSRNAQVRAAVSKITWFTWLSVMSDNFVTRFLQQLDLVQEYLDVYRPRLSHAYRQVSTALETNRIPFERAEAGLFVFIDLSAWIHHFQDPAGKPPATDNALSPELQLCEWLIDHGVFLNAGQFTGCDLPGHFRLVFTQDLDATLLGIRRIRSALDQLDHACGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZES7</accession>
    <name>C7ZES7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_86250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043055.1">
        <property type="nucleotide sequence ID" value="XM_003043009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZES7"/>
    <dbReference type="STRING" id="660122.C7ZES7"/>
    <dbReference type="GeneID" id="9665247"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86250"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86250"/>
    <dbReference type="eggNOG" id="KOG1535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_2_1_1"/>
    <dbReference type="InParanoid" id="C7ZES7"/>
    <dbReference type="OMA" id="YMHYECE"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="81"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU37342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="294" mass="31342" checksum="F1ADFA5726C4DEAB" modified="2009-10-13" version="1">MASIPAFSRLVRFVPKSDPSRILIGQPQQSGLDVGVATRRGENVSVDVFSGTSILSPGKETGVVEMIDRVLSPLAQDEVGTIRCIGLNYKQHAAEVQMDIPSIPTVFLKPANAVGDPWPAPTILPKLTQLDDCGDYESELAVIIGKAAKNVSEADALDYVLGYTAVNDISSRTSQLNQSQWSFSKGFDGACPLGPVIVSTSVIPDVSNLWLRGLKNGKVVQNCGINDLIFGVPKLVSFLSQSTTLPSGTVIITGTPAGVGLGRTPKETLRHGDEFAVEILPHIGTLFNVFENEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZF98</accession>
    <name>C7ZF98_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_78390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698923">
        <property type="protein sequence ID" value="EEU37183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042896.1">
        <property type="nucleotide sequence ID" value="XM_003042850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZF98"/>
    <dbReference type="STRING" id="660122.C7ZF98"/>
    <dbReference type="GeneID" id="9665040"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78390"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78390"/>
    <dbReference type="eggNOG" id="ENOG502RJ7F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123440_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZF98"/>
    <dbReference type="OMA" id="NRAEWEV"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU37183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="178" mass="20542" checksum="A5BD1998BF6ADD20" modified="2009-10-13" version="1">MYVTTYYTDELATTLPKHYHISPFTMGYDCGFDIYPRLEVTVENKDAYQQFLDDIIAIYEGVHDDEGRRDDGKILEMPGDTAHSDKVNICFMVGECPRMPASPDRCNYFLRFSSKISGRLTAPAEPYIRSVYIIAKRNFGSRVHFWNDLHGQSGCYGWKQVNDAEKELRELEAAKWST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFD8</accession>
    <name>C7ZFD8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AttH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_37099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698923">
        <property type="protein sequence ID" value="EEU37322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043035.1">
        <property type="nucleotide sequence ID" value="XM_003042989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFD8"/>
    <dbReference type="STRING" id="660122.C7ZFD8"/>
    <dbReference type="GeneID" id="9664987"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_37099"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_37099"/>
    <dbReference type="eggNOG" id="ENOG502SPEU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046730_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZFD8"/>
    <dbReference type="OMA" id="WAIDENT"/>
    <dbReference type="OrthoDB" id="5295747at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.370.10">
        <property type="entry name" value="AttH-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023374">
        <property type="entry name" value="AttH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053112">
        <property type="entry name" value="Fungal_Dehydratase/Hydratase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40617:SF1">
        <property type="entry name" value="ATTH DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40617">
        <property type="entry name" value="TERPENE CYCLASE ASQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17186">
        <property type="entry name" value="Lipocalin_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159245">
        <property type="entry name" value="AttH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU37322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="32420" checksum="B0849E77946E03B3" modified="2009-10-13" version="1" fragment="single">GSSWWMSSFITSTRGKQYLAIDHILTAPKNVCRSSVLDLDTLDYWVDLVYCSAKSDRTINSGGPINADFGTHGFVSTSEDSVTEMYAYADTNASFAFNISWQATSKLLLNGGAGTIAFGPGPTNATEWGLPAGKTTGSLTLNGTDVKIDPKNSFTWYDRQISYGAPRNWTWFQLHFPGSEIKASIWAWKMPDDTIYQFATVRVGDSQLVLAYDLIPDMTNTWTSPNSGLVYPLSWRLEFENGDYINVKSVRPDQEMYGPDDLVDSAYEGFITASGKFLGQKKGFGVVELVTIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZGL1</accession>
    <name>C7ZGL1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_42137</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698925">
        <property type="protein sequence ID" value="EEU36911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042624.1">
        <property type="nucleotide sequence ID" value="XM_003042578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZGL1"/>
    <dbReference type="STRING" id="660122.C7ZGL1"/>
    <dbReference type="GeneID" id="9670124"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_42137"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_42137"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002220_2_1_1"/>
    <dbReference type="InParanoid" id="C7ZGL1"/>
    <dbReference type="OMA" id="QNMGYAQ"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="564"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU36911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1043" mass="115414" checksum="6875B0E3C4C66182" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZH79</accession>
    <name>C7ZH79_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DOMON domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_102006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698927">
        <property type="protein sequence ID" value="EEU36617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042330.1">
        <property type="nucleotide sequence ID" value="XM_003042284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZH79"/>
    <dbReference type="GeneID" id="9669496"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102006"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102006"/>
    <dbReference type="eggNOG" id="ENOG502T39P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076658_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZH79"/>
    <dbReference type="OMA" id="RIQWHME"/>
    <dbReference type="OrthoDB" id="4755186at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002987101" description="DOMON domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU36617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="26428" checksum="B9E9E35A6BE942C1" modified="2009-10-13" version="1">MIHKIPLVFGVTWLYLGGALAKHNCDNRLCMTSFRWCDSSPCNFPNNILSIHSDLDDRNTGYGVILGTGEYNITWIHADSDYPVSIEWRFLVGETEPDYGGKTLSWGVNTTDSHYVFKPYDLFAKMASSPKFNLTQTEIRSLASGMINVIFIRQPGKGDAQDGWQDVSSQFSVQNGWAITAAQAQYDIGKKKEADRWKLGIGIGVGLGVPFVMTVTGLLTWWFTKKRLTSEAPKTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHF9</accession>
    <name>C7ZHF9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_104626</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698928">
        <property type="protein sequence ID" value="EEU36463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042176.1">
        <property type="nucleotide sequence ID" value="XM_003042130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHF9"/>
    <dbReference type="STRING" id="660122.C7ZHF9"/>
    <dbReference type="GeneID" id="9669207"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_104626"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_104626"/>
    <dbReference type="eggNOG" id="KOG3275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZHF9"/>
    <dbReference type="OMA" id="EIGQWLP"/>
    <dbReference type="OrthoDB" id="1915375at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF2">
        <property type="entry name" value="HIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="34"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="127"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU36463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="219" mass="24058" checksum="8D4BA89B96A07927" modified="2009-10-13" version="1">MFDPSTPPTACCPFCTICTIFKPYDPLNPPPQSSPSIDPELVSPASFIVLSTPTLIAFLDILPLSRGHLLLCPRPHRPKLTDVTDSESAELGRYLRVLSKATARATGVEDWNVVQNNGAAAAQVVPHMHFHIIPRPEIRASGRFSESFTMFGRGKREELDDDEAAQLAEELRQSVAAVLKEEEEETAVSCCLIGHSSDQRAILGSLYYILISLSNTHDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHN7</accession>
    <name>C7ZHN7_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_94113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698928">
        <property type="protein sequence ID" value="EEU36448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042161.1">
        <property type="nucleotide sequence ID" value="XM_003042115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHN7"/>
    <dbReference type="GeneID" id="9669191"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94113"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94113"/>
    <dbReference type="eggNOG" id="ENOG502SQEJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_692780_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZHN7"/>
    <dbReference type="OMA" id="EKRSKWK"/>
    <dbReference type="OrthoDB" id="4779541at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU36448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="398" mass="43625" checksum="73FE6CC7632902CA" modified="2009-10-13" version="1">MFIHEESANHKDKEKKSRWKIFSSKDKEKHSSLEPPVPDVEANSGDSTYGSSEPNNSLTTEAETSAPRSTNNTNAEIQNPSSYTSPTIRRETHTNPNTGQTTTTTTTTTTTTTTVSNANGTVSTIEEPRPPSELPTVSNQDLPRTATPKQPDQQPDQQPTSQDQTMLTPTSRRPSVETPGRRVIPPREPIPVPSPIENTPIIPERDARRKSSEVQPNNTEGLYPAPLSSPRSSVNFSHPSPKSTIQNLKCAAAGIHGAGETLRGTLNSTVDKHFGSNPQAMEKDQAAIDKGRYEVENMRFFRPNEYWQQDHESRPYTNEAPYVQGPHNEPPIAISSSTVDMGDQSHRGKLASFFKGSSYSSGQPAMNNPSKSPPPERARLKKRSSSRLAHARLGAVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZIC4</accession>
    <name>C7ZIC4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_87094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698930">
        <property type="protein sequence ID" value="EEU36180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041893.1">
        <property type="nucleotide sequence ID" value="XM_003041847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZIC4"/>
    <dbReference type="GeneID" id="9674272"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87094"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87094"/>
    <dbReference type="eggNOG" id="ENOG502S8UP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_549919_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZIC4"/>
    <dbReference type="OrthoDB" id="5082423at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42057">
        <property type="entry name" value="F-BOX DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42057:SF2">
        <property type="entry name" value="F-BOX DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00200)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU36180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="56085" checksum="6C193E5159F0CD62" modified="2009-10-13" version="1">MADPIFAPLPPELIIKILGYLSAISKSTLLNLRLVDQRTCSLATPVAFQSLFLGPNEGSPHHRALPKLRCPSSSPNLQNADRHSRTQARVSFLSALPLIRCLPNLKSLRLCFTTEMELEGFPWVEELLDYRTKVLQTIFKTLAGDWSAIEAPIIRQELETGEHPACVPDWGVRDEADQPTGPTRLDRLTLHNVPDDAWSWTAGSEHVKMAIASGSLVDLRLSIATEGPDWNTAMHGISEELHVSFNTLTSTWLSRSVAQNLKILSLSCPGGGGGFPNLKVLALKKYVFSHQWQIDWFASLGLEELELDTCAIIYEAKGHIRLSEGTTIVGQDNDGVSIKVSNKDYPIKNWMNSLQRGPVPNHLFPIRWHNILSEWRQSMTTLKSFQITAGELYARHESGLGMSFAEAHRQEHEDFRRKLFPQPSGVKVSQDHGFYYKQPLRYLYFDDMEFWNEWNSWDRSRSEDEGRGVEDGVEARDKAALLDFLETIRQRNLANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJE7</accession>
    <name>C7ZJE7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Erythromycin biosynthesis protein CIII-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_35090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698933">
        <property type="protein sequence ID" value="EEU35891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041604.1">
        <property type="nucleotide sequence ID" value="XM_003041558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJE7"/>
    <dbReference type="GeneID" id="9673975"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_35090"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_35090"/>
    <dbReference type="eggNOG" id="KOG1192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031484_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZJE7"/>
    <dbReference type="OMA" id="GANCFYE"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002989329" description="Erythromycin biosynthesis protein CIII-like C-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="4">
        <location>
            <begin position="403"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU35891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="508" mass="56670" checksum="1B5859DE7C58F6A0" modified="2009-10-13" version="1">MLRKGLFTGAILIALLGLWAANRPSTPLPPLNHGRKNVVLFVTSAHDGFCNVHLATSHALLEKYPDLEVHYASFPDLKPKVDRVSAKHPKSKPVVWHELPPPGFTDVLLRYLGSVAGLMNVPGLKGLKRAVKDIQNVVAPWNADEHWTLYKTVFDVIKEVDPAVVVLDILFKPAIEATQDLNYKHMFVTPNSFVDTCLHKEPWAAMLWKFPSTGTGYPYPVPWHLIPANIYFEIRVDYAIITGARARDMVPYLKEKGIKNPIDSLAWDRPDVPLLSGTLPEASLPLQAVPENAKYCGPIVLETAPLKEQDAEMAEWLSKAPTILVNLGSGVRFDETQARSMAQAFVPVLEKTDAQILWKRQKHDEYDDSFLQPVKQYIDSGRLRIESWIKADPTSLLATGNVKLAVHHGGANCYNEAILYGIPQVVLPVWFDTYTYAATAEYRGVGIWPTKDTAPAWEAKSLGKALLDALSDETMREKAEKLGEVARKYEGRYLVARDIAEMAAKGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJF6</accession>
    <name>C7ZJF6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_77240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698933">
        <property type="protein sequence ID" value="EEU35895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041608.1">
        <property type="nucleotide sequence ID" value="XM_003041562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJF6"/>
    <dbReference type="STRING" id="660122.C7ZJF6"/>
    <dbReference type="GeneID" id="9673927"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77240"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77240"/>
    <dbReference type="eggNOG" id="ENOG502SWNS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035152_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZJF6"/>
    <dbReference type="OMA" id="YNRWTTI"/>
    <dbReference type="OrthoDB" id="2590365at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002987156" evidence="1">
        <location>
            <begin position="21"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="574" mass="63390" checksum="BD93CDC632FFE9F2" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZK67</accession>
    <name>C7ZK67_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_52364</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698937">
        <property type="protein sequence ID" value="EEU35621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041334.1">
        <property type="nucleotide sequence ID" value="XM_003041288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZK67"/>
    <dbReference type="FunCoup" id="C7ZK67">
        <property type="interactions" value="160"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZK67"/>
    <dbReference type="GeneID" id="9676006"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_52364"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_52364"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="InParanoid" id="C7ZK67"/>
    <dbReference type="OMA" id="FCDPLTM"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF5">
        <property type="entry name" value="2-DEHYDRO-3-DEOXY-D-GLUCONATE 5-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="12"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU35621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="255" mass="26572" checksum="7809D2AA3F2801D6" modified="2009-10-13" version="1">MPALDLFSLKGKNAFVTGGSRGIGAAIAIALADAGASVCVAQRDTTSTDTMDAIRARGVRAEIVSCDLGDMDAVKKVFQQALDAMDGRIDILVNCGGILKRKEVLSVSEEEWDAVMDVNLKAVFFICQAAGNHMVPRRSGKIVNIASINSFIGGENYAPYSSSKGGVSQLTKALSNEWAKHNVQVNAIAPGYVATDMNTALRPNAELTAAAITGCPAGRWGTPADYAGPAVFLCSDASQYVTGEVLVVDGGLLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKA1</accession>
    <name>C7ZKA1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-binding enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_88739</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698938">
        <property type="protein sequence ID" value="EEU35489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041202.1">
        <property type="nucleotide sequence ID" value="XM_003041156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKA1"/>
    <dbReference type="STRING" id="660122.C7ZKA1"/>
    <dbReference type="GeneID" id="9675957"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88739"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88739"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1190182_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZKA1"/>
    <dbReference type="OMA" id="EFTIVPP"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="137"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU35489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="233" mass="25698" checksum="F6FBC9DDC4DD773F" modified="2009-10-13" version="1">MYGPGTVYWMPKFNFEDFLKDNKKHGITSFFTVPPIYMLIAHSPKVSLGTSLIAPAASLSSFQTSECGYSMTRDVTFKMVNRATFSSKALHSQLDTGMTPRPQPEPLPAADIDSKLEIKKVLSDDPVYKGLQVAPAELEATLVSHILIHVAAVIGVPDLSLANNEVPRAFVVADSTRISTKDIQTFIKNELAPQKQLRAGVVFLKQIPKSTTRKILRKVLRDQSNQTNEAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKX2</accession>
    <name>C7ZKX2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Intradiol ring-cleavage dioxygenases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_92188</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698942">
        <property type="protein sequence ID" value="EEU35274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040987.1">
        <property type="nucleotide sequence ID" value="XM_003040941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKX2"/>
    <dbReference type="GeneID" id="9675391"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_92188"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_92188"/>
    <dbReference type="eggNOG" id="ENOG502QW1S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027719_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZKX2"/>
    <dbReference type="OMA" id="PYYVWGE"/>
    <dbReference type="OrthoDB" id="121380at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03457">
        <property type="entry name" value="intradiol_dioxygenase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF2">
        <property type="entry name" value="ANCHORED DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01800)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988204" description="Intradiol ring-cleavage dioxygenases domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="3">
        <location>
            <begin position="156"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU35274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="395" mass="42161" checksum="EB4C1ABF40B935F8" modified="2009-10-13" version="1">MARLTSLLAIGLGLCSSVMSHPGEAHDPKHMAREIHARNNMAAIGRRSLESCSGSTAAQALKARSIQRRTSRVRALRAKRGITTPSKKYRRDTDDLTSWEDVNHNMTGSVSYDMFTPLADIFDANSSCILSPEITAGPYYVVGEFLRSNVIESEYCDGVPLFLEVQYVDVASCQPVPVAAVDIWNANATGVYSGISVSGNEAAGGVNSTYLRGVQITDHDGVVQFETIFPGHYQGRATHTHLLTHTNATVMPNGTISVWDAPVSHIGQLFWPETLRSAVEATYPYNTNTQDVTSNEEDMWSVLQADASFDPFPQYVYLGDKVEDGIFAWIQIGVNASVDYSTDDYYGVAGYLGEDGGHALDSGIGGGGDGGEGGGAGGPPSGAQSGMMPTGTMAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKX7</accession>
    <name>C7ZKX7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7924 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_18425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698942">
        <property type="protein sequence ID" value="EEU35276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040989.1">
        <property type="nucleotide sequence ID" value="XM_003040943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKX7"/>
    <dbReference type="STRING" id="660122.C7ZKX7"/>
    <dbReference type="GeneID" id="9675416"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_18425"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_18425"/>
    <dbReference type="eggNOG" id="ENOG502RS92">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1286013_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZKX7"/>
    <dbReference type="OMA" id="PVDECIS"/>
    <dbReference type="OrthoDB" id="5424149at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057684">
        <property type="entry name" value="DUF7924"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25545">
        <property type="entry name" value="DUF7924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7924" evidence="1">
        <location>
            <begin position="40"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="215" mass="24065" checksum="53D1FC3E1BAB2DFF" modified="2009-10-13" version="1" fragment="single">IERALNEASVVFESNSRLLKSYSDKNYNRAFNKAFTGFPKNADFNDGLSAPQPDFVEGLGVKEFHPLPIKDYVDGAVLHKDHPHSITLPHLAGEFKGPGKNLRHARLQSAYDGATLVHGRNQALDSLGEPAIAGHAKVTTFTTDGTNLNLFAHYAAPSEDGTTKYHQYPINSTILTNSLQDFKQGYRQLRNAQDCAREESYKLRDQLKEHWKARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKY8</accession>
    <name>C7ZKY8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_103897</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLT11 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698942">
        <property type="protein sequence ID" value="EEU35280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040993.1">
        <property type="nucleotide sequence ID" value="XM_003040947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKY8"/>
    <dbReference type="FunCoup" id="C7ZKY8">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZKY8"/>
    <dbReference type="GeneID" id="9675509"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_103897"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_103897"/>
    <dbReference type="eggNOG" id="KOG0153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027112_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZKY8"/>
    <dbReference type="OMA" id="CPLRVQW"/>
    <dbReference type="OrthoDB" id="10259600at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12265">
        <property type="entry name" value="RRM_SLT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000396">
        <property type="entry name" value="Putative Pre-mRNA-splicing factor slt11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034356">
        <property type="entry name" value="Slt11_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048995">
        <property type="entry name" value="STL11/RBM22-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF6">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21369">
        <property type="entry name" value="STL11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="231"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="312"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU35280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="370" mass="40058" checksum="EEB1C127D3F2DCA5" modified="2009-10-13" version="1">MPPQIKQDLNRSGWESTDFPSVCETCLPENPYVKMIKEDYGAECKLCTRPFTVFAWSATRAHGRKKRTNICLTCARLKNCCQCCMLDLSFGLPIVVRDAALKMVAPGPQSDINREYFAQNNEKLIEEGKAGTEEYEKTDEKARELLRRLANSKPYFRKGKAIEDAGEGSKGGNAAVGAGVGGPGPIRTRDTKAAIAAGAKTSVKGRQVFPSAAQLPPSPRDWQPPADKNVMSLFVTGIEDDLPEYKLREFFKVHGKIKSLVCSHMSHCAFVNYETREAAEKAAEACQGRAVIAGCPLRVRWGQPKAIGTMDKEQRAQMLKDAKQRQAGGQGQRAIEGGRGAGTRPAALPAPVAAPPGASDTPAYASLTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZL94</accession>
    <name>C7ZL94_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_87315</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698944">
        <property type="protein sequence ID" value="EEU35157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040870.1">
        <property type="nucleotide sequence ID" value="XM_003040824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZL94"/>
    <dbReference type="STRING" id="660122.C7ZL94"/>
    <dbReference type="GeneID" id="9679295"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87315"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87315"/>
    <dbReference type="eggNOG" id="KOG0684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018012_4_2_1"/>
    <dbReference type="InParanoid" id="C7ZL94"/>
    <dbReference type="OMA" id="WSEVVQM"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11040">
        <property type="entry name" value="CYP7_CYP8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053007">
        <property type="entry name" value="CYP450_monoxygenase_sec-met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47582">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47582:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="4 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU35157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="59215" checksum="563E04F8D105AB73" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMR3</accession>
    <name>C7ZMR3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_82338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698958">
        <property type="protein sequence ID" value="EEU34664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040377.1">
        <property type="nucleotide sequence ID" value="XM_003040331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMR3"/>
    <dbReference type="GeneID" id="9678807"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82338"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82338"/>
    <dbReference type="eggNOG" id="ENOG502T65X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_660716_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZMR3"/>
    <dbReference type="OrthoDB" id="5098322at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="416" mass="46642" checksum="E66851C1F6D5AC8A" modified="2009-10-13" version="1">MAPPVQSWLHRRLRWLRYFLTALDSQNDDQQPLLQQTTSSGSKSSVSCPPDFTSSPYRAEKKPGITTPSPSNQLEEDMNEPPLPFFYCRACKQARLSNEYNERVARLIDRLYCAGCQTQHPAILFSHSYRNAEPSTRLCIGHQGHYAVCCHLKLSLSDIEAWKAANQEIKLSCPLSTCPCTNVTVTYDPGWFDDPNLNHVWVKWRAPIQHTLPGNTFWDRSISKAAQLYGSCPYLFCAALQVTPGRLFRLGYFKDDTFGDGRKNRKCLKINGSFFKCDLQNEIIESSRCIPQGKDPRTLLPRDWIENLDPESYGHFTDPETKHITWCSDRSCATTLEYDLPIPTAGAVAPVILANEDNQGKGPFTHCISAGCLHPLPTMDFKTAFGTLLPINTHEAMATGPITKGPSSESSTMKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZN92</accession>
    <name>C7ZN92_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">nitrilase</fullName>
            <ecNumber evidence="4">3.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_54453</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a nitrile + 2 H2O = a carboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18379"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="EC" id="3.5.5.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.5.1" evidence="4"/>
    <dbReference type="EMBL" id="GG698964">
        <property type="protein sequence ID" value="EEU34527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040240.1">
        <property type="nucleotide sequence ID" value="XM_003040194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZN92"/>
    <dbReference type="STRING" id="660122.C7ZN92"/>
    <dbReference type="GeneID" id="9678062"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_54453"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_54453"/>
    <dbReference type="eggNOG" id="KOG0805">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_6_0_1"/>
    <dbReference type="InParanoid" id="C7ZN92"/>
    <dbReference type="OMA" id="PWANNFI"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF14">
        <property type="entry name" value="ARYLACETONITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00920">
        <property type="entry name" value="NITRIL_CHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="6">
        <location>
            <begin position="14"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00036406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU34527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="353" mass="39198" checksum="4EBC3B2F0D3F61C4" modified="2009-10-13" version="1">MAESVVDNDPNHPIKVAVVQAEPCWFNVEAAVEKTCALIAEAGANGAELVAFPELWIPGYPNFIYAHAQKTCNEYIRKYFRNSVSVDSKHMGQIRLAARRAKMTVVVLGIAEREKGSLYMAQSFIGPDGQILLHRRKFKPTSYERILFGDASGDCTTNVIQTPLGRVGGLQCFEHLQPLLKYHSYFQQEQIHVASWPNLFPLVGKMPFFNSVEACTMATHTYAIEGGAFVLLASHTQSEKVHEGGVELPDDECHTAVTGGGFTEVIAPDGRTIAKAPSPSFEGLIYAELDFNEIYLAKNIVDPVGQYSRTDLFTLQVNSNVNRHCVYREKTTEFAHTTRYPDLEPPEPENASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQ44</accession>
    <name>C7ZQ44_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_44538</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698982">
        <property type="protein sequence ID" value="EEU33872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039585.1">
        <property type="nucleotide sequence ID" value="XM_003039539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQ44"/>
    <dbReference type="STRING" id="660122.C7ZQ44"/>
    <dbReference type="GeneID" id="9667108"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_44538"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_44538"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_9_2_1"/>
    <dbReference type="InParanoid" id="C7ZQ44"/>
    <dbReference type="OMA" id="VRFCDSK"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006144">
        <property type="entry name" value="PRK08294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF10">
        <property type="entry name" value="2-MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="6"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="7">
        <location>
            <begin position="395"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU33872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="574" mass="63759" checksum="6BD8AA8F8FC765CA" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQD3</accession>
    <name>C7ZQD3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_56106</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698988">
        <property type="protein sequence ID" value="EEU33781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039494.1">
        <property type="nucleotide sequence ID" value="XM_003039448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQD3"/>
    <dbReference type="GeneID" id="9667016"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_56106"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_56106"/>
    <dbReference type="eggNOG" id="ENOG502SQ5T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024934_0_1_1"/>
    <dbReference type="InParanoid" id="C7ZQD3"/>
    <dbReference type="OMA" id="FCYSESA"/>
    <dbReference type="OrthoDB" id="5295362at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU33781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="383" mass="43321" checksum="913B2E9DAAFEC5C6" modified="2009-10-13" version="1">MSETIQCDEVRPTCFNCNRHGIPCSLSQTAPPDLKLPGPYHREASSTLLSHSSSSHSSAVDLVAPLPSDKLWYQGFELMHHWCTATADTLSSRQDVSYVWRVAVPREGYKHPFVFHGIQAFAAVHKVYLTQSQSNKDRYLELCDYHSMLGLKLFRRELQDITEHNWLALFSFASVLVLYAFTLPLRSAHQTLADPISGFLELVSLLQGMKTTLGPLRPRVYRSELAPLVYGIWPGEVKEVTGGYPSLDNTFLPPDLWDATRQLRFFLETEVPPESLTHYRDAVNSLEYSARLVALAGAQAESGTVIAAFWTLNEKILVDIGCRKPYTLVLVAYYCVYLAGLNRTFWYARGWVEQVFDQVERSLASHAAFKSMLEWPRTHVSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQR8</accession>
    <name>C7ZQR8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chromate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_73264</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG699009">
        <property type="protein sequence ID" value="EEU33640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039353.1">
        <property type="nucleotide sequence ID" value="XM_003039307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQR8"/>
    <dbReference type="GeneID" id="9666873"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_73264"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_73264"/>
    <dbReference type="eggNOG" id="ENOG502QRJG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018106_0_2_1"/>
    <dbReference type="InParanoid" id="C7ZQR8"/>
    <dbReference type="OMA" id="VWGMART"/>
    <dbReference type="OrthoDB" id="2160638at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014047">
        <property type="entry name" value="Chr_Tranpt_l_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33567">
        <property type="entry name" value="CHROMATE ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33567:SF3">
        <property type="entry name" value="CHROMATE ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004810">
        <property type="entry name" value="ChrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="211"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU33640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="53017" checksum="14F5D34DF325777E" modified="2009-10-13" version="1">MVVNNWEYTARRVGRRTWETIQVNWHLGFTAFGGPPVHFKIFHDKFVSKLAWIDEQLYQELFSISQALSGPASTKMLYCINLIHDGLLGAVLAFFIWSLPGTLGMFGLSIGVSNIGETLPRPVYALLSGLNAATVGIIALAAVELSNKAITDKLTRILVFLTAAAGMLYNALWYFPVLMFAAGFAAVVYDYRWFHRPIRAVKQLVSRMQGTTPTQGENIAGDESGPSRETNATSITLNDQDRYGTRESEPRIVPHEYRLNFSWKSGTALIAAFFVTFIIVMVLRGVLPDPPLLYKLFANLYLAGTIIFGGGPVVIPLLREYIVAEGWVSPRDFLIGLAIAQAFPGPNFNFAVFLGGLTAIHSGYSSIAGALIAFCGIFFPGIVLVHGTMGVWGVLRSRRWVKSGVRGVNAGAVGLIYTAVYRIWQIGYIDEGFQSGKSLADDPWWVVVTAAAYVGGRYFSIAAPLAILLGAVLGLVRYGVVIGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-04-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>H6D5C9</accession>
    <name>H6D5C9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LAGLIDADG intron encoded protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nad5-i1</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="2"/>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="2" last="14">
            <title>Comparative analysis of Fusarium mitochondrial genomes reveals a highly variable region that encodes an exceptionally large open reading frame.</title>
            <authorList>
                <person name="Al-Reedy R.M."/>
                <person name="Malireddy R."/>
                <person name="Dillman C.B."/>
                <person name="Kennell J.C."/>
            </authorList>
            <dbReference type="PubMed" id="22178648"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2011.11.008"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
            <strain evidence="2">MpVI</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JN041209">
        <property type="protein sequence ID" value="AEJ72905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H6D5C9"/>
    <dbReference type="STRING" id="660122.H6D5C9"/>
    <dbReference type="InParanoid" id="H6D5C9"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.28.10:FF:000010">
        <property type="entry name" value="LAGLIDADG homing endonuclease I-LtrII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051289">
        <property type="entry name" value="LAGLIDADG_Endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36181">
        <property type="entry name" value="INTRON-ENCODED ENDONUCLEASE AI3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36181:SF4">
        <property type="entry name" value="LAGLIDADG ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00961">
        <property type="entry name" value="LAGLIDADG_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homing endonuclease LAGLIDADG" evidence="1">
        <location>
            <begin position="139"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Homing endonuclease LAGLIDADG" evidence="1">
        <location>
            <begin position="299"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEJ72905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="429" mass="48829" checksum="88E40EAB532E72AB" modified="2012-04-18" version="1" fragment="single">RGYVRGKRNCGDKLPNSGELLKLKVPSYSWKTISGWSNYSGMVTSLKICENKMDNRGSKSTVYKNTVVKEQRVDGSWSINKNLIGLRCTLTGFERNRGINLGFNLQPSWNFCVKVPSKQFDIRKFSTYNSTGLIHPWVWSGLIDGEGSFGIIVDRNKTRKLGWRSQLKFQIGLHTKDLNVLQLLQQYLGGIGSIHLARNREIVNYSIDSIEGLNKLMDHFEKYPLLTQKAADLLLFKQAIKLVNDKAHLTVEGLNQIINIKASMNLGLSDMLKLEFPEYTSVERPVINNDNILLDPNWISGFVSAEGNFDVRMPSTNSKLGTRVQLRFRISQHSRDNRLLEKIAEYFGSGKVYKYSGKSAVSYSTVDFTNITNVIIPFFNNNSIIGIKLYDYLDWCKIHSLMINRSHLTAEGIISIREIKSCMNTGREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-04-18" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>H6D5D0</accession>
    <name>H6D5D0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 17">Cytochrome b</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">cob</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="20"/>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="2" last="14">
            <title>Comparative analysis of Fusarium mitochondrial genomes reveals a highly variable region that encodes an exceptionally large open reading frame.</title>
            <authorList>
                <person name="Al-Reedy R.M."/>
                <person name="Malireddy R."/>
                <person name="Dillman C.B."/>
                <person name="Kennell J.C."/>
            </authorList>
            <dbReference type="PubMed" id="22178648"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2011.11.008"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
            <strain evidence="20">MpVI</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="17">Binds 2 heme groups non-covalently.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="16">Binds 2 heme groups non-covalently.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14 17">Belongs to the cytochrome b family.</text>
    </comment>
    <dbReference type="EMBL" id="JN041209">
        <property type="protein sequence ID" value="AEJ72896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H6D5D0"/>
    <dbReference type="FunCoup" id="H6D5D0">
        <property type="interactions" value="639"/>
    </dbReference>
    <dbReference type="STRING" id="660122.H6D5D0"/>
    <dbReference type="InParanoid" id="H6D5D0"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00290">
        <property type="entry name" value="cytochrome_b_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00284">
        <property type="entry name" value="Cytochrome_b_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.810.10:FF:000002">
        <property type="entry name" value="Cytochrome b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="entry name" value="Cytochrome Bc1 Complex, Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005798">
        <property type="entry name" value="Cyt_b/b6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036150">
        <property type="entry name" value="Cyt_b/b6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005797">
        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030689">
        <property type="entry name" value="Cytochrome_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048260">
        <property type="entry name" value="Cytochrome_b_C_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048259">
        <property type="entry name" value="Cytochrome_b_N_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19271">
        <property type="entry name" value="CYTOCHROME B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19271:SF16">
        <property type="entry name" value="CYTOCHROME B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00032">
        <property type="entry name" value="Cytochrom_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00033">
        <property type="entry name" value="Cytochrome_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038885">
        <property type="entry name" value="COB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81648">
        <property type="entry name" value="a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="Transmembrane di-heme cytochromes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51003">
        <property type="entry name" value="CYTB_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51002">
        <property type="entry name" value="CYTB_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 16 17" id="KW-0349">Heme</keyword>
    <keyword evidence="11 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17 20" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 17" id="KW-0813">Transport</keyword>
    <keyword evidence="20" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="290"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b/b6 N-terminal region profile" evidence="18">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b/b6 C-terminal region profile" evidence="19">
        <location>
            <begin position="212"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <label>b562</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <label>b566</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <label>b562</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <label>b566</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>a ubiquinone</name>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR038885-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR038885-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AEJ72896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="390" mass="43985" checksum="637BD638C17F351B" modified="2012-04-18" version="1">MRILKNHPLLKLANGYLIDASQPSNISYLWNFGSLLLVCLVIQIVTGVTLAMHYNPSVLEAFNSVEHIMRDVNNGWLVRYLHSNTASAFFFLVYLHIGRGIYYASYRAPRTLTWVIGTIILIVMIVTGFLGYVLPYGQMSLWGATVITNLISAVPWIGQDIVEFIWGGFSVNNATLNRFFALHFVLPFILAALVLMHMIALHDTAGSSNPLGVPVYYDRMPMAPYFLFKDLITIFIFIFVLGMFVFFMPNVLGDSDNYIMANPMQTPPAIVPEWYLLPFYAILRSIPNKLLGVIAMLAAILIILILPKTDLGLTKGLQFRPLSKIVFYIFLINFLMLMQLGAKHVESPFIEIGQLSTALYFSHFLFILPAVSILENTLVDLELQNNTKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7YH88</accession>
    <name>C7YH88_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_90126</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053588.1">
        <property type="nucleotide sequence ID" value="XM_003053542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YH88"/>
    <dbReference type="STRING" id="660122.C7YH88"/>
    <dbReference type="GeneID" id="9664460"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90126"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90126"/>
    <dbReference type="eggNOG" id="ENOG502QVAF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017851_2_0_1"/>
    <dbReference type="InParanoid" id="C7YH88"/>
    <dbReference type="OMA" id="KKVHTEQ"/>
    <dbReference type="OrthoDB" id="644067at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416:SF8">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="240"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="231"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU47875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="611" mass="68025" checksum="BBEE156B8905FB23" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHF6</accession>
    <name>C7YHF6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUF726 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_65677</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054338.1">
        <property type="nucleotide sequence ID" value="XM_003054292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YHF6"/>
    <dbReference type="FunCoup" id="C7YHF6">
        <property type="interactions" value="82"/>
    </dbReference>
    <dbReference type="GeneID" id="9664569"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_65677"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_65677"/>
    <dbReference type="eggNOG" id="KOG2385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001695_1_0_1"/>
    <dbReference type="InParanoid" id="C7YHF6"/>
    <dbReference type="OMA" id="KEVGWEV"/>
    <dbReference type="OrthoDB" id="277931at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035650">
        <property type="term" value="F:AP-1 adaptor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035652">
        <property type="term" value="P:clathrin-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF3">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="482"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="526"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="344"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="934"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="348"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="946"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="956"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="978"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="999"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1040"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1053"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1074"/>
            <end position="1084"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU48625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1084" mass="118651" checksum="E81FD958C4969FBB" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C7YI42</accession>
    <name>C7YI42_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_90287</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054455.1">
        <property type="nucleotide sequence ID" value="XM_003054409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YI42"/>
    <dbReference type="STRING" id="660122.C7YI42"/>
    <dbReference type="GeneID" id="9664761"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90287"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90287"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002833_1_2_1"/>
    <dbReference type="InParanoid" id="C7YI42"/>
    <dbReference type="OMA" id="NPMTYDF"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000677">
        <property type="entry name" value="Chitinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF228">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00551">
        <property type="entry name" value="2SGLOBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="3">
        <location>
            <begin position="6"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU48742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="345" mass="37413" checksum="728029626A8F179A" modified="2009-10-13" version="1">MSNVMFTNAVYFPNYRIYQGDTPGMLNYSCINHVYYAYASVSADGGVFLSDEWADAGAPVDGVQGGLGSLMHLKQKHPHLRVVLSVGGGNSSEVFPLVASNTLLRDNFARSARGLVEASGLDGIDIAWEYPCDAQQGYDFLALLAAIRIHLPEEHYILTAALPANKAILQFLDLKLVTEYLDFINLMAYDFFGSWTPKAGHHSQLYAMNKEETSGSAGVSYLMSKGFPPKKILLGIPTFGRSFLHCSGAGHKFKGVGGAEDGTFEYNQLPRKGCKEVVDKRHVAAQCVGADGGFVTYDNPDTVKIKAGFCKQKGLGGLFYWNGPADAKEKSRSLIAAGFRALHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIC9</accession>
    <name>C7YIC9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LNS2/PITP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_57597</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lipin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053789.1">
        <property type="nucleotide sequence ID" value="XM_003053743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIC9"/>
    <dbReference type="FunCoup" id="C7YIC9">
        <property type="interactions" value="462"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YIC9"/>
    <dbReference type="GeneID" id="9676415"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_57597"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_57597"/>
    <dbReference type="eggNOG" id="KOG2116">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002546_3_0_1"/>
    <dbReference type="InParanoid" id="C7YIC9"/>
    <dbReference type="OMA" id="QDYSMKL"/>
    <dbReference type="OrthoDB" id="4567at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000063">
        <property type="entry name" value="Nuclear elongation and deformation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007651">
        <property type="entry name" value="Lipin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057124">
        <property type="entry name" value="Ned1-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF12">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04571">
        <property type="entry name" value="Lipin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24565">
        <property type="entry name" value="Ned1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="4">
        <location>
            <begin position="428"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="95"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="319"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="636"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="681"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="638"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="703"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU48076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="766" mass="84244" checksum="16A95EB24A3D03DD" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7YID8</accession>
    <name>C7YID8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_75284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054499.1">
        <property type="nucleotide sequence ID" value="XM_003054453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YID8"/>
    <dbReference type="STRING" id="660122.C7YID8"/>
    <dbReference type="GeneID" id="9676420"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75284"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75284"/>
    <dbReference type="eggNOG" id="ENOG502RIU6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021593_0_0_1"/>
    <dbReference type="InParanoid" id="C7YID8"/>
    <dbReference type="OMA" id="CPLIHFG"/>
    <dbReference type="OrthoDB" id="5428138at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU48786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="790" mass="89718" checksum="BC3240C5D241CF75" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJZ5</accession>
    <name>C7YJZ5_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Expressed protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_103043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053364.1">
        <property type="nucleotide sequence ID" value="XM_003053318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJZ5"/>
    <dbReference type="GeneID" id="9676696"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_103043"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_103043"/>
    <dbReference type="HOGENOM" id="CLU_2270173_0_0_1"/>
    <dbReference type="InParanoid" id="C7YJZ5"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002986274" evidence="2">
        <location>
            <begin position="20"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU47651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="103" mass="11191" checksum="4A4667899217F097" modified="2009-10-13" version="1" fragment="single">MTLLAAPAATLILPPCCRFACIAELCCPPPALHPQPNNSPPPSSSRPRPRPRPRRTQLDKIERCSLRPSSSHSACDPTTDVAFLTLKQPAPLRASLPPPRVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C7YK55</accession>
    <name>C7YK55_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <ecNumber evidence="3 11">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_31997</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="3 11"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054102.1">
        <property type="nucleotide sequence ID" value="XM_003054056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YK55"/>
    <dbReference type="FunCoup" id="C7YK55">
        <property type="interactions" value="570"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YK55"/>
    <dbReference type="GeneID" id="9664033"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_31997"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_31997"/>
    <dbReference type="eggNOG" id="KOG0563">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013524_2_3_1"/>
    <dbReference type="InParanoid" id="C7YK55"/>
    <dbReference type="OMA" id="ERAGYYE"/>
    <dbReference type="OrthoDB" id="60984at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000015">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000111">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF0">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 11" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="6 11" id="KW-0521">NADP</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="12">
        <location>
            <begin position="10"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="13">
        <location>
            <begin position="189"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU48389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="495" mass="57044" checksum="B311F77DF87D8950" modified="2009-10-13" version="1">MELKQNTTIVVLGASGDLAKKKTYPALFGLYRNQFLPQDVKIVGYARTKMDHEEYIRRIKSYMKTPTKESEQQLEEFCNLCTYVSGQYDKDESFQVLEQHLQDIEKGRAEAHRLFYMALPPSVFTIVSQHLKKVCYPSKGIARVIVEKPFGKDLASSRELQKSLEPDWNEQELFRIDHYLGKEMVKNILILRFGNSFLGATWNRHHIDNVQISFKEPFGTEGRGGYFDEFGIIRDVMQNHLLQVLTLLAMERPISFNAEDIRDEKVRVLRAIPAIEPKNVIIGQYGKSLDGSKPAYREDDTVPKDSRCPTFCAMVAYIKNERWDGVPFIIKAGKALNEQKTEIRIQFKDVTSGIFKDIPRNELVMRIQPNESVYIKMNSKLPGLSMQTVVTELDLTYRRRFSDLKIPEAYESLVLDCLKGDQSNFVRDDELDASWRVFTPLLHYLDENKEIIPMEYPYGSRGPAVLDDFTASYGYKFSDAAGYQWPTTNATPNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7YKY1</accession>
    <name>C7YKY1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_77334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052869.1">
        <property type="nucleotide sequence ID" value="XM_003052823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YKY1"/>
    <dbReference type="STRING" id="660122.C7YKY1"/>
    <dbReference type="GeneID" id="9670944"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77334"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77334"/>
    <dbReference type="eggNOG" id="ENOG502S18D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_616900_0_0_1"/>
    <dbReference type="InParanoid" id="C7YKY1"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU47156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="49616" checksum="1F4EED71BDFA557D" modified="2009-10-13" version="1">MEAPDKIVGPFTQWNPDIQRSDTIKLDDLEITFNRFTPAAGGSSRDDMPPSIGSFPLFNASDHTAKVAQRGDRVITMSQREAMSVSFSSQKEYTIKIYSGSVNAISGELTVDTTEPPLHRLNLIQGGSFAQNYTLVLPPGCESQDAGHDTMGMLRFEISRLDRSPTESYEGRFKSPRYAIKLHGLFSNVFFSVHDGTPITDLIFTLRTAGCKSRDNRDNMTPTYTIRHNGKFLGPDDTLGDHKVQDGDTIYASTDRHRIVGLSGYPEYGDSAREMNTVAFDIHILNKTHTHFPLSIHTIFKTPLAHHKNIARKLLKTAQDLTQWDPKIPLSDTIKLDGLEITFHRTVRLPDNFDENKLPPSLGQFPLFNVGEYAAKLPSVMAQKGGLFFPMFQREAMWIGFSSQKKYAVKIYSGNVNVISGETAVETANTSLHRSRLLKKGKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLQ2</accession>
    <name>C7YLQ2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">4-dimethylallyltryptophan N-methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.261</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_91762</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>4-(3-methylbut-2-enyl)-L-tryptophan + S-adenosyl-L-methionine = 4-(3-methylbut-2-enyl)-L-abrine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:34435"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58209"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:67248"/>
            <dbReference type="EC" id="2.1.1.261"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Alkaloid biosynthesis; ergot alkaloid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.261" evidence="8"/>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053022.1">
        <property type="nucleotide sequence ID" value="XM_003052976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YLQ2"/>
    <dbReference type="STRING" id="660122.C7YLQ2"/>
    <dbReference type="GeneID" id="9671062"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_91762"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_91762"/>
    <dbReference type="eggNOG" id="ENOG502SNB7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049766_0_1_1"/>
    <dbReference type="InParanoid" id="C7YLQ2"/>
    <dbReference type="OMA" id="IWAAYHS"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017804">
        <property type="entry name" value="MeTrfase_EgtD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017805">
        <property type="entry name" value="SAM_MeTrfase_EasF-type_put"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03439">
        <property type="entry name" value="methyl_EasF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF1">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018005">
        <property type="entry name" value="UCP018005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0017">Alkaloid metabolism</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="10">
        <location>
            <begin position="40"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU47309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="357" mass="40568" checksum="6BC214774FA708FC" modified="2009-10-13" version="1">MHSKTSVATNGTVVDIGGSKMYDSVAERLAETLNAPYSSTSKPVLPDELLYDDVGLPIWNQIIFTPEFYQTHDEIALFDKHGADIAKRVQAGVTVIDLGAGDTRKVGHLLAAFDKAKVPTKYLALDISKSSLVHNIRYLVDKHSKANSSVTCAGIWGTFQDGMEYVQKIETPRLFLSLGSVLCNDPWPEALSHLKYWASALRPDDLLLIGMDGHILPNNREKIWDAYHSCDDLYHTFFLNGFKHANQLAGEEWFREEDWEFLAQLEHEPTTRHRFFFRANKDVKLKMGRTIKKGEEFDWFDSHKYGEDSVRLMCYKAGLSVLDVWQAPNSEFRQYLVRRRGDKDEQDDADSAVSGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7YMA4</accession>
    <name>C7YMA4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein N-terminal and lysine N-methyltransferase EFM7</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Elongation factor methyltransferase 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">EFM7</name>
        <name evidence="2" type="ORF">NECHADRAFT_103780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono- and dimethylation of 'Lys-3'.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053129.1">
        <property type="nucleotide sequence ID" value="XM_003053083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YMA4"/>
    <dbReference type="GeneID" id="9671157"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_103780"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_103780"/>
    <dbReference type="eggNOG" id="KOG2920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_482486_0_0_1"/>
    <dbReference type="InParanoid" id="C7YMA4"/>
    <dbReference type="OMA" id="GHEIFTR"/>
    <dbReference type="OrthoDB" id="2106152at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03223">
        <property type="entry name" value="Methyltr_EFM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025784">
        <property type="entry name" value="EFM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40470">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G15850)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40470:SF1">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G15850)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51560">
        <property type="entry name" value="SAM_MT_NNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="81"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU47416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="609" mass="68489" checksum="C3A6289C3F7262CD" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>C7YMM2</accession>
    <name>C7YMM2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein kinase MEC1</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">ATR homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">DNA-damage checkpoint kinase MEC1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Mitosis entry checkpoint protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">NECHADRAFT_92026</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053184.1">
        <property type="nucleotide sequence ID" value="XM_003053138.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="C7YMM2">
        <property type="interactions" value="1172"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YMM2"/>
    <dbReference type="GeneID" id="9671220"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_92026"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_92026"/>
    <dbReference type="eggNOG" id="KOG0890">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000178_4_1_1"/>
    <dbReference type="InParanoid" id="C7YMM2"/>
    <dbReference type="OMA" id="SMYIGWC"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00892">
        <property type="entry name" value="PIKKc_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000017">
        <property type="entry name" value="Inositol kinase kinase (UvsB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000031">
        <property type="entry name" value="Phosphatidyl inositol 3-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056802">
        <property type="entry name" value="ATR-like_M-HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058681">
        <property type="entry name" value="HEAT_MEC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012993">
        <property type="entry name" value="UME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF125">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MEC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25385">
        <property type="entry name" value="HEAT_MEC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25030">
        <property type="entry name" value="M-HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08064">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00645">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00802">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0469">Meiosis</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FAT" evidence="25">
        <location>
            <begin position="1293"/>
            <end position="1860"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="24">
        <location>
            <begin position="1974"/>
            <end position="2283"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="26">
        <location>
            <begin position="2280"/>
            <end position="2311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="2490"/>
            <end position="2704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="2516"/>
            <end position="2526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="2545"/>
            <end position="2554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="2648"/>
            <end position="2658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="2659"/>
            <end position="2668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="2674"/>
            <end position="2688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="2692"/>
            <end position="2704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00029679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00030459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00033001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="EEU47471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="2704" mass="304133" checksum="3D4C2972CA93404C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C7YMR5</accession>
    <name>C7YMR5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_92059</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052711.1">
        <property type="nucleotide sequence ID" value="XM_003052665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YMR5"/>
    <dbReference type="GeneID" id="9671243"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_92059"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_92059"/>
    <dbReference type="eggNOG" id="KOG1812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025203_1_0_1"/>
    <dbReference type="InParanoid" id="C7YMR5"/>
    <dbReference type="OMA" id="GEFIPPR"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="211"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="215"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="678"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="412"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="490"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU46998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="699" mass="78736" checksum="C3BAE9A0D2EDD1FF" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNK5</accession>
    <name>C7YNK5_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_92907</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052297.1">
        <property type="nucleotide sequence ID" value="XM_003052251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNK5"/>
    <dbReference type="STRING" id="660122.C7YNK5"/>
    <dbReference type="GeneID" id="9672857"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_92907"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_92907"/>
    <dbReference type="eggNOG" id="ENOG502SS3N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042086_0_0_1"/>
    <dbReference type="InParanoid" id="C7YNK5"/>
    <dbReference type="OMA" id="MTFFNFQ"/>
    <dbReference type="OrthoDB" id="2830640at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU46584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="483" mass="56201" checksum="A9F83AEC0CC5B7F6" modified="2009-10-13" version="1">MDDYMFRYYVNECRTVYEDTGYVEIFNYSDPLYNSSEEHPLPDDEFDNFLHRRGAFAPPDNLRHGTKLLSGVRLIVQKNAKHNDTFLSKVISLPCDRYASMVRELRLPFRGIETTSVVGPFFWCAYDQDDDDPHLQIIHRKSDVLKKGKTRGWEMLLSYSFKTGITTGFIKGTPSSEVEKTLVHLQACAAEVGHPMLLPIIILSYDLSPENDNKQRKARHWLRRLENAVSLRNEVEEQEQYFQDGLIDVDGLNRDLVECHGNVMWKRPQAYMALAKEMEKAMENFRYLWNTTASEDMCEAERKYRKELDKLHRSMVARLDFYKVKLTGLENYIHTTLERLKVQREAREARLNLEIAGEQRRIAHASKRDSTAMKTLSLMGALFLPGTYLASVFSMTFFDFGKGADPVVSIQLWVYFAIAVPVTALIVGCWMYLDRRRREQHKKDDADLEKNIDKMEKEIMFALRKRTMSKANTWNTANPPPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>C7YP85</accession>
    <name>C7YP85_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Translation initiation factor IF-2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_99904</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051966.1">
        <property type="nucleotide sequence ID" value="XM_003051920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YP85"/>
    <dbReference type="FunCoup" id="C7YP85">
        <property type="interactions" value="512"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YP85"/>
    <dbReference type="GeneID" id="9668592"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_99904"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_99904"/>
    <dbReference type="eggNOG" id="KOG1145">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006301_8_3_1"/>
    <dbReference type="InParanoid" id="C7YP85"/>
    <dbReference type="OMA" id="TIVCYQI"/>
    <dbReference type="OrthoDB" id="361630at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03692">
        <property type="entry name" value="mtIF2_IVc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000007">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000008">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000001">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000019">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF20">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01176">
        <property type="entry name" value="IF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="478"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="130"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="454"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="748"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="748"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="782"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU46253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1002" mass="109235" checksum="7DE8E5F30FD743CD" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPJ1</accession>
    <name>C7YPJ1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_102529</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052018.1">
        <property type="nucleotide sequence ID" value="XM_003051972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YPJ1"/>
    <dbReference type="STRING" id="660122.C7YPJ1"/>
    <dbReference type="GeneID" id="9668646"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102529"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102529"/>
    <dbReference type="eggNOG" id="ENOG502S36W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075131_0_0_1"/>
    <dbReference type="InParanoid" id="C7YPJ1"/>
    <dbReference type="OMA" id="YILPRMP"/>
    <dbReference type="OrthoDB" id="5366541at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.70">
        <property type="entry name" value="Get5 dimerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049256">
        <property type="entry name" value="Get5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024737">
        <property type="entry name" value="Get5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047154">
        <property type="entry name" value="UBL4A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46555">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46555:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17183">
        <property type="entry name" value="Get5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12754">
        <property type="entry name" value="Get5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="61"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU46305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="203" mass="22259" checksum="F59976B7D624E135" modified="2009-10-13" version="1">MSETAFAQTFLGSLQSRPLRLSADHVEDPKTFPARPPYIIPRMPKAMSKPTHLAPGSERSVTVSLKSLRNPPLSIKLTSQPLDTSVLDIKSSVQKQTRIPVAKMKLLHNKKPVPDSKILKDLLGDTDMSIEFTVMVIGGAAAIPPEEPEAAPEVLPTGKDALETEEFWSDLKGFLMQRLKDEAQAEELSGLFKSSWQSSQASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPQ6</accession>
    <name>C7YPQ6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">NECHADRAFT_78838</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052046.1">
        <property type="nucleotide sequence ID" value="XM_003052000.1"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YPQ6"/>
    <dbReference type="GeneID" id="9673274"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78838"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78838"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001037_0_0_1"/>
    <dbReference type="InParanoid" id="C7YPQ6"/>
    <dbReference type="OMA" id="QLPGYTW"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000003">
        <property type="entry name" value="Histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000044">
        <property type="entry name" value="Putative sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000285">
        <property type="entry name" value="Putative sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000579">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF46">
        <property type="entry name" value="HISTIDINE KINASE_RESPONSE REGULATOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="113"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="16">
        <location>
            <begin position="1947"/>
            <end position="2172"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="17">
        <location>
            <begin position="2221"/>
            <end position="2345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="57"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="475"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="687"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2179"/>
            <end position="2208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2347"/>
            <end position="2437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2457"/>
            <end position="2578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="510"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="540"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="687"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="2366"/>
            <end position="2375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="2377"/>
            <end position="2390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="2391"/>
            <end position="2408"/>
        </location>
    </feature>
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        <location>
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</entry>
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                <person name="Rodriguez-Carres M."/>
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                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
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                <person name="Zhou S."/>
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                <person name="Freitag M."/>
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                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
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                <person name="Gribskov M."/>
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                <person name="Kroken S."/>
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</entry>
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        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
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                <person name="Rodriguez-Carres M."/>
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                <person name="Grimwood J."/>
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                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
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                <person name="Gribskov M."/>
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                <person name="Kroken S."/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU46373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="485" mass="52746" checksum="543B7C368FA9C930" modified="2009-10-13" version="1">MDGFPESRRQHSPASSASPQIERSKLSEAPAEGYEFNATQPPAPDVAQYATSPSPPSMIDYASTGALNTNSASTGSAVTQLTPNDDTSTGKSYTRERVPREPKHHKNKAAHRLSALSSSGSEPHSVGHDGGFVSASQELSYFKSKSRSPQAPMLEYPSPGISAPNEPYSQEQPYSQEASYPPEPPYSQPPVNPGWGPNYSGPAYPPYPYPPPPGQQPGLRPLSQQYPSGYGYLDPKATTLSTAFANRSSFHESQYPDAQDMMAGNRNGPGGNIDIPFADLTGYARIASAITGQVLPGVRPLYRRFEWLHHRLLLSYQDQLVELEDELIDLDAVSTVTRRREQGRRDLPCSEREERTEDSPYKRDKTRTMRDIGHVLDAYTQRNLIVQPETEFLRAADLVCVAREPPADAPRAADDNAEAGGDEAAPQPEVPLRALINGFSAGFACLAVSLVALPDLTSRLIVVLCFVVLAAVVMMATGNARHLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRN8</accession>
    <name>C7YRN8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_41158</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051207.1">
        <property type="nucleotide sequence ID" value="XM_003051161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YRN8"/>
    <dbReference type="GeneID" id="9665912"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_41158"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_41158"/>
    <dbReference type="eggNOG" id="KOG2615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_54_5_1"/>
    <dbReference type="InParanoid" id="C7YRN8"/>
    <dbReference type="OMA" id="RTIGPMV"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF6">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="70"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU45494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="593" mass="64363" checksum="3CB8CAD591F56521" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRT0</accession>
    <name>C7YRT0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kinetochore protein mis13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_61231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050841.1">
        <property type="nucleotide sequence ID" value="XM_003050795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YRT0"/>
    <dbReference type="STRING" id="660122.C7YRT0"/>
    <dbReference type="GeneID" id="9666009"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_61231"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_61231"/>
    <dbReference type="eggNOG" id="ENOG502S2VJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021697_1_0_1"/>
    <dbReference type="InParanoid" id="C7YRT0"/>
    <dbReference type="OMA" id="FQFTRAG"/>
    <dbReference type="OrthoDB" id="3364649at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013218">
        <property type="entry name" value="Dsn1/Mis13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14778">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14778:SF2">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08202">
        <property type="entry name" value="MIS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU45128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="58438" checksum="CAA60E23770108C8" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRV5</accession>
    <name>C7YRV5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 13">Chitin synthase</fullName>
            <ecNumber evidence="2 13">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">NECHADRAFT_61264</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chitin synthase family. Class III subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 13"/>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051243.1">
        <property type="nucleotide sequence ID" value="XM_003051197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YRV5"/>
    <dbReference type="STRING" id="660122.C7YRV5"/>
    <dbReference type="GeneID" id="9668014"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_61264"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_61264"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004760_0_1_1"/>
    <dbReference type="InParanoid" id="C7YRV5"/>
    <dbReference type="OMA" id="WHLTYIK"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF11">
        <property type="entry name" value="CHITIN SYNTHASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 13" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="566"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="619"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="652"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="703"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="735"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="831"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="871"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="15">
        <location>
            <begin position="138"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEU45530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="906" mass="101832" checksum="718D31776A312FDE" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7YS38</accession>
    <name>C7YS38_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_41873</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051284.1">
        <property type="nucleotide sequence ID" value="XM_003051238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YS38"/>
    <dbReference type="GeneID" id="9666060"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_41873"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_41873"/>
    <dbReference type="eggNOG" id="ENOG502QS4K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036005_1_0_1"/>
    <dbReference type="InParanoid" id="C7YS38"/>
    <dbReference type="OMA" id="HYQPAFN"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF10">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="58"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU45571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="379" mass="42260" checksum="80604AEA73FDC5B9" modified="2009-10-13" version="1">MSPPAAEIDVQTTAPAVQPVTKTVVGTKSSGTKSNSASRLDGPLTYSGSLDSEEQFDVTAVIGREFPKLQLSEILKDDTKLRDLAVLISQRGVVFFRNQDINIEDQKYLGQRLGELTGKPETSKLHRHALSNSKRGIAVDENGKLDDEVSVISSEQNRKFYSDRFSSLSRSLAGEGWHADITFENIPSDYAILKIIQPPEDVGGDTLWASGYELYDRLSPPIQKLAESLTATHHQPNFVRVKNEFGQELIDENRGSPENNGLDFKAEHPVIRTNPVTGWKSLFAAGHQLTAGHINGVTETESEILKNYFRQLITENHDLQVRFRWGKNDLAIWDNRSVFHTATNDYIGKRQGNRVVSLGERPYFDPASKSRREALGVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7YT68</accession>
    <name>C7YT68_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="13">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NECHADRAFT_41824</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
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        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
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            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
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    </comment>
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        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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    </comment>
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    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="10 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="14">
        <location>
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</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7YU91</accession>
    <name>C7YU91_FUSV7</name>
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        <recommendedName>
            <fullName evidence="3">RNB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_71907</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the RNR ribonuclease family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome 9"/>
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        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="C:cytoplasmic stress granule"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
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    </dbReference>
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        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0008298">
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:mRNA catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903450">
        <property type="term" value="P:regulation of G1 to G0 transition"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="Cell wall biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000002">
        <property type="entry name" value="Cell wall biogenesis protein"/>
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    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000100">
        <property type="entry name" value="Cell wall biogenesis protein phosphatase"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041093">
        <property type="entry name" value="Dis3l2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF9">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17877">
        <property type="entry name" value="Dis3l2_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="3">
        <location>
            <begin position="474"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="226"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="330"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="824"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="931"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="834"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="931"/>
            <end position="943"/>
        </location>
    </feature>
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        <location>
            <begin position="944"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="971"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1000"/>
            <end position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU44762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1091" mass="121340" checksum="F2FE8EEC9D69EBE6" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7YUV5</accession>
    <name>C7YUV5_FUSV7</name>
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        <recommendedName>
            <fullName evidence="1">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_85054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="660122.C7YUV5"/>
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    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85054"/>
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    </dbReference>
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    <dbReference type="InParanoid" id="C7YUV5"/>
    <dbReference type="OMA" id="LICIKEV"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="1">
        <location>
            <begin position="590"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU44475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="906" mass="100934" checksum="D7220967D498C2D3" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVE1</accession>
    <name>C7YVE1_FUSV7</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_85243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003050237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVE1"/>
    <dbReference type="GeneID" id="9675068"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85243"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85243"/>
    <dbReference type="eggNOG" id="ENOG502RC62">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093912_0_0_1"/>
    <dbReference type="InParanoid" id="C7YVE1"/>
    <dbReference type="OMA" id="AVCATIT"/>
    <dbReference type="OrthoDB" id="5146670at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988706" evidence="2">
        <location>
            <begin position="20"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU44570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="266" mass="27254" checksum="34F00DDAFAE963A4" modified="2009-10-13" version="1">MQSTLLWGLLASSPLLADALGRSTTKTATKTVFLPPRQTGTVKNIYASIITEEESKTEYLLACQTNFKSPYTCGGEFTGITVTYEKSMVDISFNTTTYDCELGTAAVCATKTQSSGDAATTTLAPSESSAWMTPITVLEVQKKKTIKKKKTTATAAPTAGSSSKLCKRKVHHGSSGGDSSSGSSGSSGSSGSSGSSSSDSDSSDGTSSGTKTGSGSSTSDDDDTTTSQSSKSKSKNNDDDCSGASRLTGTWGFLGLALSGYIVANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVL5</accession>
    <name>C7YVL5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_73999</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU43814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049527.1">
        <property type="nucleotide sequence ID" value="XM_003049481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVL5"/>
    <dbReference type="GeneID" id="9677306"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_73999"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_73999"/>
    <dbReference type="eggNOG" id="ENOG502SNVB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015493_0_2_1"/>
    <dbReference type="InParanoid" id="C7YVL5"/>
    <dbReference type="OMA" id="HYFNTMA"/>
    <dbReference type="OrthoDB" id="5130013at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF39">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU43814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="55287" checksum="17F5BFF4A696B46E" modified="2009-10-13" version="1">MSQRGYRKVLCDRTLPTCTRCARAGRRCDGYGTRLSWPREGDARRAVIGPAPIERRRYDARHFVNTSTGDIEMHALISGVDFGYATSGQNPTMRQLILNNLENQPTESMQVFQPVLSPAISLASYSLMAFGHDASKIREVLVRMALSDNSPCATAILKSALALASYHRDRDHSHADRLKIAALRALAASTQGVIGADESIRHVAAGMLLCTLEIYQMSAASSHWLWYVCGSKLIIKNAKLDEITGSNDMTTLIGWVHYSDVLARFSLRHWQPDLLEGTGSPIGAHFEPFRPTVCAEVQPAHLVGPPHEVLYLLSEVCDAVVEPSDPRFHTHDYQQYLKLLEWKLRKIDISTDDNNTLTDGSRSDSDKAVELYQLATLIYLKRASPDNPKERSRLPEWIERSFEILSQLEHCQRPFPLLILGCEARTDDQRAMVLDLISRTERSIHFRNPGSIKMMIQRIWVQNDLIEEEFNYVHKLGVVLSSANRSIPALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7YW08</accession>
    <name>C7YW08_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ca2+-modulated nonselective cation channel polycystin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_89674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU43883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049596.1">
        <property type="nucleotide sequence ID" value="XM_003049550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YW08"/>
    <dbReference type="GeneID" id="9677380"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89674"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89674"/>
    <dbReference type="eggNOG" id="ENOG502SFF8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035522_0_0_1"/>
    <dbReference type="InParanoid" id="C7YW08"/>
    <dbReference type="OMA" id="AKNNPYP"/>
    <dbReference type="OrthoDB" id="5377012at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988310" description="Ca2+-modulated nonselective cation channel polycystin" evidence="2">
        <location>
            <begin position="20"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU43883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="45313" checksum="A9F1B11EA909F0A0" modified="2009-10-13" version="1">MSMLLQLRLLHFPLPFRHSLLFSTVIVSPPPSAAQHRCPAFDLNISDSPKRFSNSMATTDAISQEHDRQGQRRRPFTTWVKKLTNFKSSDGERHKRHKKRTHKKNNPYPESGHVGNDVPDGTSACTFTTTQTGTSNTSVNGSSRVSTENQAPPTVGRRSLAGTVLTDHEASRSITAPSHGASSLAGTSRTVGGGVESRRGGDSTFSSPAPSVRSLTTTLTTIQSMAPNGAGQGHNNGNAHAQSTTQSIQFSQPFPTTAAPASAIPAHLAPTGNPTTYTSATANNLLTDNASILTLASSSKRRRRRSLDTDASVRALAPSSLWGGSRESLPLSVLSANIDATGMPPTPGLHGGPRMGTERTSIYSATGVGPAISSDRNSFYAKQGDGASVRSGLLGHGRAESVSGSIGGLSSPLITPREKENTPTTSTTKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWC9</accession>
    <name>C7YWC9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_30478</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049870.1">
        <property type="nucleotide sequence ID" value="XM_003049824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWC9"/>
    <dbReference type="GeneID" id="9677227"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_30478"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_30478"/>
    <dbReference type="eggNOG" id="ENOG502SRJN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055491_1_1_1"/>
    <dbReference type="InParanoid" id="C7YWC9"/>
    <dbReference type="OMA" id="TLYCYFC"/>
    <dbReference type="OrthoDB" id="5290969at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF3">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="6">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="118"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU44157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="171" mass="18543" checksum="4A9D81C93752C5F6" modified="2009-10-13" version="1">MEARCQCGSVSFKTPLPQPLALYICHCNACRRQTGSAFGTSAIFPRFNLPETDQLSCYSRPTESGHQLYCYFCRNCGTRLIHSTPTKNVVSVKGGCLEGLDWKRAIHIWTKSAMVPIPEGSETHSEESGFTDYGTTQEDLDQPGDLVGSGGCNDPPKKSEDVVVGGCDLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWI5</accession>
    <name>C7YWI5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_57056</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU43963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049676.1">
        <property type="nucleotide sequence ID" value="XM_003049630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWI5"/>
    <dbReference type="STRING" id="660122.C7YWI5"/>
    <dbReference type="GeneID" id="9677251"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_57056"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_57056"/>
    <dbReference type="eggNOG" id="KOG3752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2278188_0_0_1"/>
    <dbReference type="InParanoid" id="C7YWI5"/>
    <dbReference type="OMA" id="DVSWHWV"/>
    <dbReference type="OrthoDB" id="407198at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09280">
        <property type="entry name" value="RNase_HI_eukaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="8">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU43963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="102" mass="11258" checksum="2D33E6078145EEFD" modified="2009-10-13" version="1">MAILRALQIAPLDQAVQIFTDSQYSIKCVTQWARSWEAKGWKTANGAEVKNQDIIRQLLAKKREREKAGGATYFEWVKGHASSRGNIAADKLAVDGADLSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7YX66</accession>
    <name>C7YX66_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_45187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049243.1">
        <property type="nucleotide sequence ID" value="XM_003049197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YX66"/>
    <dbReference type="STRING" id="660122.C7YX66"/>
    <dbReference type="GeneID" id="9676923"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45187"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45187"/>
    <dbReference type="eggNOG" id="KOG1072">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004253_10_0_1"/>
    <dbReference type="InParanoid" id="C7YX66"/>
    <dbReference type="OMA" id="HGEMIYL"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU43530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="36604" checksum="9E2031051F546294" modified="2009-10-13" version="1">MPISVDKPCQHWTTLAKLPRLRQEHSTVSVDDNTIAVIGGATPIGNASLFTVFTTVDWPHLYDIPPNSWRTGAPSPYRVNHPNVATKNGSIYLLGGLVDASDPPKPLPEWVASGESHVYDSQTDTWTQLESMPPGTERGSAILGVHHELIYVAGGMTILDGAYQDAVTTVTAFNTTSGKWERLVDVAANIPEGRQHAAGAIVDETLYITGGRWFEKTNVRDDVFMLDLNNLTAGWKTGKTHMPTARGGISGAAVGAKLYTFGGETNQHAATGVFDNVEVFDKWEELTPMQVPRHGTSAATVGNKIYIPGGGLQQDGLMIMVDGVGHFLNTTDHFEVLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXH5</accession>
    <name>C7YXH5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SUI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_45519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049053.1">
        <property type="nucleotide sequence ID" value="XM_003049007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXH5"/>
    <dbReference type="FunCoup" id="C7YXH5">
        <property type="interactions" value="495"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YXH5"/>
    <dbReference type="GeneID" id="9666286"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45519"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45519"/>
    <dbReference type="eggNOG" id="KOG2522">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012487_1_0_1"/>
    <dbReference type="InParanoid" id="C7YXH5"/>
    <dbReference type="OMA" id="MFLKPYR"/>
    <dbReference type="OrthoDB" id="199771at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11608">
        <property type="entry name" value="eIF2D_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000008">
        <property type="entry name" value="eukaryotic translation initiation factor 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039757">
        <property type="entry name" value="EIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039759">
        <property type="entry name" value="eIF2D_SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048248">
        <property type="entry name" value="PUA_eIF2d-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057429">
        <property type="entry name" value="WH_eIF2D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26292">
        <property type="entry name" value="PUA_elF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25304">
        <property type="entry name" value="WHD_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="2">
        <location>
            <begin position="548"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU43340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="641" mass="69963" checksum="92ACCF80B68B3D7F" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXZ1</accession>
    <name>C7YXZ1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_45282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049390.1">
        <property type="nucleotide sequence ID" value="XM_003049344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXZ1"/>
    <dbReference type="GeneID" id="9677026"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45282"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45282"/>
    <dbReference type="HOGENOM" id="CLU_004184_6_0_1"/>
    <dbReference type="InParanoid" id="C7YXZ1"/>
    <dbReference type="OMA" id="ASERILW"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="128"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU43677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="271" mass="30920" checksum="01DEA68F212F1069" modified="2009-10-13" version="1" fragment="single">MHEELEKQVRSYAPVSWTQDGSLKGISSRRLPLRESPATAPKTFHEFDYQRFINKKRETISISIVPAFGTLPFELQPASSLQGEETGKRYRYKPLAKDEIRLLEIQPGPAGPITVSISHASLRNPPKYRALSYVWGDATRQMPVECTNGQKVWVTENCYAALKRLRLSDKSVTFWIDAICINQRDTPERNSQVQIMATIYRKAQGITIYLGEEDQEGSLAMETLEKATFSPTCTIRAKSTDPARSQDPDVVALRNLFARPWFRRVWVLQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYT2</accession>
    <name>C7YYT2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-mRNA-splicing factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_6115</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in spliceosome maturation and the first step of pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the SPP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048962.1">
        <property type="nucleotide sequence ID" value="XM_003048916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYT2"/>
    <dbReference type="STRING" id="660122.C7YYT2"/>
    <dbReference type="GeneID" id="9665539"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_6115"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_6115"/>
    <dbReference type="eggNOG" id="ENOG502RZY8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047291_1_0_1"/>
    <dbReference type="InParanoid" id="C7YYT2"/>
    <dbReference type="OMA" id="AWGKSAM"/>
    <dbReference type="OrthoDB" id="5577072at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045166">
        <property type="entry name" value="Spp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026822">
        <property type="entry name" value="Spp2/MOS2_G-patch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818">
        <property type="entry name" value="G PATCH AND KOW-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818:SF2">
        <property type="entry name" value="G-PATCH DOMAIN AND KOW MOTIFS-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12656">
        <property type="entry name" value="G-patch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Spp2/MOS2 G-patch" evidence="6">
        <location>
            <begin position="205"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="227"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="274"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU43249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="304" mass="34095" checksum="D37DC2CDC2E79590" modified="2009-10-13" version="1" fragment="single">RIAIKFGAPSNNNSKKLSRPNPPSALGKRPRSHALGGASDSESADDDQHRGRHEKITGFGADGAETERKAKDARTEKKEYVIARQANRDWRSEVKAQKKGKNLLPEEARAQQAGVSVETEPADQDKGLKWGLTIKEKTAGDEQGDAEPETEDTAPKDDASKEPPQKRTADDEAMDALLGNKVEDEKVIHLNEEDAYLRDIKETGEASTLDDYEAMPVEEFGAALLRGMGWDGKPRGAVKEVKRRPNRLGLGAKELKEAEDLGGWNQGGKKNRRPRLDEYRREESKRKDSRRNEDSYKRERERER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYX2</accession>
    <name>C7YYX2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_83836</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Vacuole membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048787.1">
        <property type="nucleotide sequence ID" value="XM_003048741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYX2"/>
    <dbReference type="STRING" id="660122.C7YYX2"/>
    <dbReference type="GeneID" id="9665979"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83836"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83836"/>
    <dbReference type="eggNOG" id="KOG0232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085752_1_2_1"/>
    <dbReference type="InParanoid" id="C7YYX2"/>
    <dbReference type="OMA" id="IMSNNIK"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="123"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="14"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="90"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU43074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="162" mass="17022" checksum="CE895F3487D57C26" modified="2009-10-13" version="1">MDRCPMYASFFGAMGCAVSIVFTTFGAAYGTAKSAGAIFQSGILRPDMLMQNTLCAIMAQILSIYGLVASVIMSNGIKEKMPIHTGFLQLGAGIAVGLCGMAAGFAIGIVGDAGVRASAQQPRLYVGMVLILIFAEVLGLYGVIVSILMLTRSKMDVTECRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZH8</accession>
    <name>C7YZH8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Class II aldolase/adducin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_47568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048320.1">
        <property type="nucleotide sequence ID" value="XM_003048274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZH8"/>
    <dbReference type="STRING" id="660122.C7YZH8"/>
    <dbReference type="GeneID" id="9667771"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_47568"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_47568"/>
    <dbReference type="eggNOG" id="KOG3699">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_1_2_1"/>
    <dbReference type="InParanoid" id="C7YZH8"/>
    <dbReference type="OMA" id="FRIIAHL"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF25">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 14 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="2">
        <location>
            <begin position="50"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU42607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="289" mass="31513" checksum="6DA184A7D074794F" modified="2009-10-13" version="1">MSSTATITATAAPQSQSSLNVSTDKDGKVKRLQKIPQFATKEATRRWQLEQMAGAFRVFARLGYADGSSGHISLRDPVQPNTFWINPYGVHFGLIKVSDLVHIDEEGNRIGGADKLVNKAGFIIHAAIHKRRPDINAACHLHSPYGRAWSTFGKPIEMINQDSCMFYKDLAVYANFGGVVFAKEEGARLADALGATKKNIILQNHGLLTSGGTIGEAAAFFIALERACQAQLLVESAVAPDGSQLAKTLVSDEEAQYTKDGTGTPEVMYLQFEPEYQYELKRSGGDFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z065</accession>
    <name>C7Z065_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">NECHADRAFT_71472</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048444.1">
        <property type="nucleotide sequence ID" value="XM_003048398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z065"/>
    <dbReference type="FunCoup" id="C7Z065">
        <property type="interactions" value="863"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z065"/>
    <dbReference type="GeneID" id="9667521"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_71472"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_71472"/>
    <dbReference type="eggNOG" id="KOG1147">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001882_1_2_1"/>
    <dbReference type="InParanoid" id="C7Z065"/>
    <dbReference type="OMA" id="ANRYFFV"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000037">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000004">
        <property type="entry name" value="Glutamyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02076">
        <property type="entry name" value="Glu_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF5">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="13">
        <location>
            <begin position="116"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="14">
        <location>
            <begin position="432"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="15">
        <location>
            <begin position="534"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEU42731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="631" mass="71386" checksum="60A8EAE4A53F7CB6" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z089</accession>
    <name>C7Z089_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_47366</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048458.1">
        <property type="nucleotide sequence ID" value="XM_003048412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z089"/>
    <dbReference type="GeneID" id="9667535"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_47366"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_47366"/>
    <dbReference type="eggNOG" id="KOG2633">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029822_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z089"/>
    <dbReference type="OMA" id="RWPNEEL"/>
    <dbReference type="OrthoDB" id="6077599at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02908">
        <property type="entry name" value="Macro_OAADPr_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF121">
        <property type="entry name" value="ADP-RIBOSE 1''-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Macro" evidence="10">
        <location>
            <begin position="88"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="9">
        <location>
            <begin position="293"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU42745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="592" mass="65623" checksum="664A66C01D3D3FA4" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0F9</accession>
    <name>C7Z0F9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chloramphenicol phosphotransferase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_79879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047908.1">
        <property type="nucleotide sequence ID" value="XM_003047862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0F9"/>
    <dbReference type="STRING" id="660122.C7Z0F9"/>
    <dbReference type="GeneID" id="9667260"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79879"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79879"/>
    <dbReference type="eggNOG" id="ENOG502SD2T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092496_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z0F9"/>
    <dbReference type="OMA" id="VPIYWIN"/>
    <dbReference type="OrthoDB" id="5426988at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="27368" checksum="FCDA5DBD767765B1" modified="2009-10-13" version="1">MIKHKLLMVIGHLRPIADARKRGVSSTSNDATPNPTSVNPQRPPMRAATPSQQALRGKIIVLNGFPGTGKLPILKKVKELLPTETACLLDNHLLIDPVAAVIPGRSQEHHELRRKIRAPIFEKLQERAQKGHTILMTACLVEDDERDASVLQEHLDMAHEADVPIFWINVHCSQEILQQRVASIERCSGTKTKLTDPTLACDLVDKHRLIKPHKTDNSMEGLLFATLDVSGSVELSVSGLMRIIKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0V5</accession>
    <name>C7Z0V5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial export translocase Oxa2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_93302</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048162.1">
        <property type="nucleotide sequence ID" value="XM_003048116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0V5"/>
    <dbReference type="STRING" id="660122.C7Z0V5"/>
    <dbReference type="GeneID" id="9671965"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_93302"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_93302"/>
    <dbReference type="eggNOG" id="KOG1239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029282_1_1_1"/>
    <dbReference type="InParanoid" id="C7Z0V5"/>
    <dbReference type="OMA" id="WAHSVGV"/>
    <dbReference type="OrthoDB" id="2148490at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF65">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX18, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU42449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="32743" checksum="19BE51150CE871FE" modified="2009-10-13" version="1">MSLFKRTAHVLSPHARPFLPISTTRRQASTPCAGRRSFHLASTVGDTIRMTADAFSWIHVNAGMPWYVAIPLLAIGVNATLRFPLQLYTARLRQRRAELQPLLMAWAARHTKTIMQEQRHVPEPVQRVRTAGLVEKSRRRIYKNWGTQRWKGMAPMISIVPFLTISEALRRKCGAPVGWISNSVGLGNPDSATAGLGAASSMFDESLVNGGCLWFNDLSSMDPYFGLPIICSGILVWNTWGKMSKEHLQSLLTINLPDSKKDVASDANLSAPLCGSPERHLHLLGFFICPHRHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0W1</accession>
    <name>C7Z0W1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Asparaginase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_40402</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048165.1">
        <property type="nucleotide sequence ID" value="XM_003048119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0W1"/>
    <dbReference type="STRING" id="660122.C7Z0W1"/>
    <dbReference type="MEROPS" id="T02.004"/>
    <dbReference type="GeneID" id="9671968"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_40402"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_40402"/>
    <dbReference type="eggNOG" id="KOG1592">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021603_5_2_1"/>
    <dbReference type="InParanoid" id="C7Z0W1"/>
    <dbReference type="OMA" id="MKHRGRI"/>
    <dbReference type="OrthoDB" id="77601at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04514">
        <property type="entry name" value="Taspase1_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.30:FF:000007">
        <property type="entry name" value="Similar to threonine aspartase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037464">
        <property type="entry name" value="Taspase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF8">
        <property type="entry name" value="THREONINE ASPARTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="170"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="278"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="2">
        <location>
            <begin position="356"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU42452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="57120" checksum="E0F1AEEA2C859CA3" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z275</accession>
    <name>C7Z275_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_51034</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU42123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047836.1">
        <property type="nucleotide sequence ID" value="XM_003047790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z275"/>
    <dbReference type="GeneID" id="9671621"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51034"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51034"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="InParanoid" id="C7Z275"/>
    <dbReference type="OMA" id="IMAICNG"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF10">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="55"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU42123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="508" mass="55760" checksum="97366088C9D899BB" modified="2009-10-13" version="1">MPDARDDGDNDPAQPLLTSSCHGEQIPPRQALSPQEANPDTEAAREVLRKIDRTIIPLLFITYMLSFMDKIILSSAAVFGLREDNKLEGQQYSWVGSVFYMGYLQWTYPTNLLVTRLPAGKYLSANTLFWGSVVTLTAACNSFGGLLTVRFLLGAAEATITPGFMFLTSTWYTRDEMPTRVGIWFAGNSVGGLVASLLAFGVGHIDNTAIRPWRWMYIILGSATLLWAIPMFILLPDNISKAKFLTPKERQVAAQRIASAGTGTTENTHWKQDQFHECLADPKTWFIVGIELLTQIPNGGSQSFANIVVASFGFTNLQSTLINIPYSLLSAGIISGSGYLAGHFRTWNCILIIGVILPCVFGSALIYNRSHLPHGLHLFAYFLLSSGSAAMPLNMALVQSNYRGVTKKSTITVMLFIAYCIGNMVGPHFFRESEDPLYETAFKAIIVCYSLAIICAVALRVYLGRLNAKRTREEGILGSAGSGGVSRGVGDAPEDITDWQAVGFRYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z2T1</accession>
    <name>C7Z2T1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_54014</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047245.1">
        <property type="nucleotide sequence ID" value="XM_003047199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z2T1"/>
    <dbReference type="GeneID" id="9671445"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_54014"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_54014"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="C7Z2T1"/>
    <dbReference type="OMA" id="RYAIFWA"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF86">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="44"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU41532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="494" mass="54491" checksum="AF7B92E88D1BA2C2" modified="2009-10-13" version="1">MLHQTSEHAGIIIDEAINVPGYDATLNIEPGETRRALLKVDFGILPFIVLCFCFLQFDRTNVGNALTDTLREDINIDNSDINLAQTLFTVGFIVTELPFNLISRYMGPERFLPITMFLWGIATWSQMFLKNAAGLYAARFFVGALEGGYIPGFALYISKYYTNNELALRYSIFWASNSFAGALGGPLSIGLLSLRGRGGLQGWQWLFLIGKFTKSPGVLTCFLGVLAYLYFPHSAAKPKSFFGRSFNIFTEREASILVTRVIRNDPTKALRYGKPVLPSHILETFMDWRLYGHLVAALLSMVMISPMNTYAPSIIKSLGFTSLQANGLNSVGSVCALIWSVSLAFSSDKFRERGFHIAVGYLWGAAGLLWLALAPDNVSKWTLYGGVVWTQMGMGCVQAISAAWLTTKMQDYKRPIALAAYVMSIQLANFPGNQLFRAQDAPRYTRGLSIAAGCTIAAAVVILVWKLLYRLFDHGDAGVEAEFQVAPAEETGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z3R6</accession>
    <name>C7Z3R6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_46071</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046896.1">
        <property type="nucleotide sequence ID" value="XM_003046850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z3R6"/>
    <dbReference type="GeneID" id="9675737"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_46071"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_46071"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012970_1_1_1"/>
    <dbReference type="InParanoid" id="C7Z3R6"/>
    <dbReference type="OMA" id="FLIWDGR"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore-iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF87">
        <property type="entry name" value="SIDEROPHORE IRON TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="532"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU41183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="587" mass="63882" checksum="9F87637052B4CCD1" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z3S2</accession>
    <name>C7Z3S2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Indoleamine 2,3-dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_70795</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046900.1">
        <property type="nucleotide sequence ID" value="XM_003046854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z3S2"/>
    <dbReference type="STRING" id="660122.C7Z3S2"/>
    <dbReference type="GeneID" id="9675741"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_70795"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_70795"/>
    <dbReference type="eggNOG" id="ENOG502SIY6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033932_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z3S2"/>
    <dbReference type="OMA" id="TYELGPA"/>
    <dbReference type="OrthoDB" id="10262710at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.480:FF:000005">
        <property type="entry name" value="Indoleamine 2,3-dioxygenase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF3">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU41187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="56560" checksum="9C8F49DA10E4C4EB" modified="2009-10-13" version="1">MAAVNTLFPYLRKDPSELPAGEDPFTITTRMGYLPFALPLKRLPSQFDALYNILNDMPILKEDGAPGLLATFELGPLIDNGAIPDLTDEIDKLVIPGTDKRDMAAITAAFRDYSFVASSYLLEPCWETYSADRSNGYGLGRRVLPKCIAGPLVKCAEILDIPAFMSYAASYALYNYWLVHPEQGHDDYNNIRLVRAFEKGLDPKSSEAGFILTHIHMVAQTGGLIEGAVDLLEAVEKESKDGSKDSKTITDAKASLELILNAMQIIEANMEGMWTQSLPKDYMTYRTFIYGITNQSMFPNGVIYEGQYDNKPQFFRGESGANDAIIPLLDHICEIPMPKNPLTDILVEFREYRPKPHRAFLKYVRETASELGVRRFMTESGDLSLVVLYLRVLDHVRSFRWRHWMFTREYIIKHTLHPTATGGSPIITWLPNQLGAVMDLMEEVAKGSGLWAVLEEGVWNGGGSLSEEDFILVKKIMDNVVTKKAQLKKEVAKYCQDRGVESSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4A5</accession>
    <name>C7Z4A5_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_83537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047160.1">
        <property type="nucleotide sequence ID" value="XM_003047114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4A5"/>
    <dbReference type="GeneID" id="9675330"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83537"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83537"/>
    <dbReference type="HOGENOM" id="CLU_1518285_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z4A5"/>
    <dbReference type="OrthoDB" id="4998165at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU41447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="177" mass="20206" checksum="929459F986F4A314" modified="2009-10-13" version="1">MSSVASVQYLVNCILEQCDFKFMTMTLFNENEFWISAIERVAGGWEEAIPPYHFIRLVKAILTARYNHIEAHGFQLPDGDVACSADILLFNFLLYSIDHQTVSGIPRVPVPGWDTDTIEYRLACSRLHKAQRWARVHGSTLRSDPAVFDELAAMILTRGPPTKTLQSLQEEYEDWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4P4</accession>
    <name>C7Z4P4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcium-binding protein NCS-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_58324</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046670.1">
        <property type="nucleotide sequence ID" value="XM_003046624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4P4"/>
    <dbReference type="FunCoup" id="C7Z4P4">
        <property type="interactions" value="141"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z4P4"/>
    <dbReference type="GeneID" id="9678475"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_58324"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_58324"/>
    <dbReference type="eggNOG" id="KOG0044">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072366_1_2_1"/>
    <dbReference type="InParanoid" id="C7Z4P4"/>
    <dbReference type="OMA" id="EYVFNVF"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000009">
        <property type="entry name" value="Visinin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF178">
        <property type="entry name" value="NEUROCALCIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU40957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="190" mass="22013" checksum="77A5677400680C24" modified="2009-10-13" version="1">MGKSQSKLSQDQLVELQKSTHFDKKELQQWYKGFLKDCPSGTLTKEEFQKIYRQFFPFGDPSSFADYVFNVFDSDKSGNIDFKEFICALSVTSRGKMEDKLDWAFQLYDIDGDGKISYDEMLKIVEAIYKMVGSMVKLPEDEDTPEKRVKKIFRMMDKDENGSLDMEEFKEGSKRDETIVSALSLYDGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6R5</accession>
    <name>C7Z6R5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RTA1 like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_66202</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046453.1">
        <property type="nucleotide sequence ID" value="XM_003046407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6R5"/>
    <dbReference type="GeneID" id="9668724"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_66202"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_66202"/>
    <dbReference type="eggNOG" id="ENOG502QU4U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033465_6_1_1"/>
    <dbReference type="InParanoid" id="C7Z6R5"/>
    <dbReference type="OMA" id="LAPTFIC"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF8">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU40740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="35410" checksum="CB49ACF09C96426B" modified="2009-10-13" version="1">MLDAVLNELARRRPASFDDCSEISALCPVDATVLGYVPNRGSSIFFALAFGILCISSVGLGVWKKTWTYAATLGVGLLLETLGYIGRALMNPNPWNSAAFQLQICCIIIAPTFICAAIYLTLKHVALALNPSLSRFHPRWYPRVFLPADLSCLIIQAIGGGVAAAAKRDQPGVAESGNRTIIAGVVLQVIVLLGFGVMGTDYYLRVRKYIHSSEVDPAALRVWTDTKFRRFTFAVVGAYCSILTRCIYRIAEMAGGWGNHIMQDEPSFLVLDSSLVLITGFLLTAFHPGLFFPQMATGLSEKNVTEAEMTAESSDERKVENSQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7D0</accession>
    <name>C7Z7D0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_66366</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045994.1">
        <property type="nucleotide sequence ID" value="XM_003045948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7D0"/>
    <dbReference type="FunCoup" id="C7Z7D0">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z7D0"/>
    <dbReference type="ESTHER" id="nech7-c7z7d0">
        <property type="family name" value="CGI-58_ABHD5_ABHD4"/>
    </dbReference>
    <dbReference type="GeneID" id="9668349"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_66366"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_66366"/>
    <dbReference type="eggNOG" id="KOG4409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017361_3_0_1"/>
    <dbReference type="InParanoid" id="C7Z7D0"/>
    <dbReference type="OMA" id="ADQHLVM"/>
    <dbReference type="OrthoDB" id="7457040at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042171">
        <property type="term" value="F:lysophosphatidic acid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF29">
        <property type="entry name" value="PUMMELIG, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="118"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="243"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU40281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="476" mass="53973" checksum="DF4C2F271C990E7A" modified="2009-10-13" version="1">MSTADGAVRPPRAADAPEEFKHQPELKPSSAFLFPLGYKDAAYQWWTSLAPQAVERNLLKLMPHLKEANDSITNIDTPDRPDPYGTRVWRRTMVHLSGKNRALNEVTVERVGEETEDALVMIHGYGAGLGFFYKNFEPLSRMRGLKLYALDMLGMGNSTRPPFKIHAKKKEDQVLEAESWFVDALEEWRKARKLEQFTLLGHSLGGYLAVSYAIKYPGRLKKLILASPVGVPEDPYAVNADMPDPNSSSMANEFTEDQQSTTEPTGTLSKHKPASNVLRRPLPGWFVWLWDQNISPFSIVRMSGPLGPRFVSGWSYRRFNHLPQLESQALHDYSFSIFKQKGSGEYALAYILAPGAYARRPVINRIQEVGRQLIPQPDGAPPKRETGLPIVFMYGENDWMDVAGGLAAQEKLNERRLKALLHGTEEEKRNENGTTKVHLVPKAGHHLYLDNPDEFNDLIRKELEETRADERRKREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7D9</accession>
    <name>C7Z7D9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NDT80 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_33281</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045997.1">
        <property type="nucleotide sequence ID" value="XM_003045951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7D9"/>
    <dbReference type="GeneID" id="9668355"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_33281"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_33281"/>
    <dbReference type="eggNOG" id="ENOG502RY09">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026383_1_1_1"/>
    <dbReference type="InParanoid" id="C7Z7D9"/>
    <dbReference type="OMA" id="VWTCYRR"/>
    <dbReference type="OrthoDB" id="2288358at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1390">
        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052605">
        <property type="entry name" value="Fungal_trans_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144:SF2">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NDT80" evidence="4">
        <location>
            <begin position="67"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="2">
        <location>
            <begin position="67"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="313"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU40284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="499" mass="54269" checksum="48F4E0303957B985" modified="2009-10-13" version="1" fragment="single">SSSTSSTGMAHPYPPSHRTAALPHPGPQISTRDQYTPATPSFRRPSEHATRSPSFATQHRGRHPLSPTTSPNTVFSTAAPSMGSSGYTSRPAPNNIPPLQAVHMMGNLQYADGAGTPVKAEIQGVIDKGFFLSENEWTCYRRNYFSCICSFSLNPHLPGVSIQYTATGSNQPVQVYGFAMCISAVVSDNEQHNIELVQHTPKRDKGPIMKPEKVRLGVKPPQASHHHHMGMYPDVASRPVYSDSFSSQPGGQQLPTEHTFERIQFKQATQNNGKRRAAQQYYQLVVELWADVGSNGSNGDSFVKVATRKSAKMIVRGRSPGHYQNDRRGSQSSGPGGSAGNLGPFGPIGGMDFNTNPMMNPPGYGGGGGAFDNRGHVYGVRQHDIPPESMITTEEAKAINSVREYQYYPGPIYEAQNERVELFNPRTERNDVVPPHMATGLDVGSKIKTDYDSTTLPSIFQPPAHLGDRTPAPFEGKSTSTGYYPTSMVPSSGINMTMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7E8</accession>
    <name>C7Z7E8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_58149</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046573.1">
        <property type="nucleotide sequence ID" value="XM_003046527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7E8"/>
    <dbReference type="FunCoup" id="C7Z7E8">
        <property type="interactions" value="430"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z7E8"/>
    <dbReference type="GeneID" id="9668987"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_58149"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_58149"/>
    <dbReference type="eggNOG" id="KOG0817">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118853_2_0_1"/>
    <dbReference type="InParanoid" id="C7Z7E8"/>
    <dbReference type="OMA" id="RYKFEAW"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="5"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU40860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="105" mass="11593" checksum="C9AD62424FAE9104" modified="2009-10-13" version="1">MAAPQSDAFKKAIEDSKKLTSKPGPDELLQLYALYKVGTGEDFSKATAPGTFDFKGKAKYNAWKKVVDEGVTPDAAQEQYVKLVEELKEKYGYDENKVPEAVGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z879</accession>
    <name>C7Z879_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_79694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045533.1">
        <property type="nucleotide sequence ID" value="XM_003045487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z879"/>
    <dbReference type="GeneID" id="9672434"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79694"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79694"/>
    <dbReference type="eggNOG" id="ENOG502RME3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_496136_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z879"/>
    <dbReference type="OrthoDB" id="3431997at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="2">
        <location>
            <begin position="301"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU39820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="549" mass="61360" checksum="E60BA2C2AFDA43DC" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8A0</accession>
    <name>C7Z8A0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_79715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045546.1">
        <property type="nucleotide sequence ID" value="XM_003045500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8A0"/>
    <dbReference type="GeneID" id="9672574"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79715"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79715"/>
    <dbReference type="eggNOG" id="ENOG502SCUT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082466_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z8A0"/>
    <dbReference type="OMA" id="AWGNEII"/>
    <dbReference type="OrthoDB" id="3780330at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988584" evidence="1">
        <location>
            <begin position="26"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="270" mass="30874" checksum="63024ED8687EF71D" modified="2009-10-13" version="1">MAGLTFSHPLVLLVLLLAFSHFLEAADFSRNRQPKGDLKVRLDYALATNGGRNKRLKSETAHKWVFSTYLVFNEPVSSITSGQLKQIAFDAFDEMAEDIMQYDPENEARTGRPRRLPGVMTIMAFDNEIILASSQKGSVAFLSRYPDNPVSQTLDLCQTAWRDQVLSQEPENEQKATQDHFRQRKCGEVSTFFQYYQIHDKKIADLAPKARDVWGCNLLVKHANIDVDYFQNDVQEEPYDLDEIAGGIKKIGQIQMHPCNDNEKVLWSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8A1</accession>
    <name>C7Z8A1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_79716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045674.1">
        <property type="nucleotide sequence ID" value="XM_003045628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8A1"/>
    <dbReference type="GeneID" id="9672448"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79716"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79716"/>
    <dbReference type="eggNOG" id="ENOG502RMC1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047750_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z8A1"/>
    <dbReference type="OMA" id="FTWPAAH"/>
    <dbReference type="OrthoDB" id="4191831at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="440" mass="49387" checksum="28B4A6A6F832E26C" modified="2009-10-13" version="1">MGLLDFPTEAQLAIAELLPLCDLSALSMTSKGLRHVVEPRIYSSIKMKWTLQDHPPIMLLLRTILKRPDLGGHIRRLELDGEGFLLPSRQWIPQNPAALPNIVHLQVEDLYRVANSAGAEENTSSWVHEAQSGSPNAVVAFLLSLSPNLQWLSLSCNWTNEIKYIGLVFRSALCKTAMDDLSPQLPTYDLLKHVEFAPRVDTENFPGPENTLEALSLFYLPNLEHLTVCIDNPIEFSWPCSAPPNPLLLTSLELDRIRETRLEPLLSALKNLRKLQYNWFFQADMDPKVSNSVVRLDTMATALAVLKDTLTELTITGETQPALSLSEYDPPDVTFQGSLGQLSQLHRLKRMHIPWVFVMGMSDPSPGRIGSILPPSLECLRLPAYVWCTDDNEWHDELIFAAVKSELESGGLSGMEHLKRITLPGSYHMNEEENPGTRNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8M7</accession>
    <name>C7Z8M7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M50B-like-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_70119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045103.1">
        <property type="nucleotide sequence ID" value="XM_003045057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8M7"/>
    <dbReference type="STRING" id="660122.C7Z8M7"/>
    <dbReference type="GeneID" id="9673189"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_70119"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_70119"/>
    <dbReference type="eggNOG" id="ENOG502QPXP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066780_0_1_1"/>
    <dbReference type="InParanoid" id="C7Z8M7"/>
    <dbReference type="OMA" id="LSVNHTQ"/>
    <dbReference type="OrthoDB" id="40823at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049500">
        <property type="entry name" value="Peptidase_M50B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979">
        <property type="entry name" value="OS02G0221600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979:SF2">
        <property type="entry name" value="PEPTIDASE M50B-LIKE-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13398">
        <property type="entry name" value="Peptidase_M50B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="28838" checksum="DF3C488928956B7F" modified="2009-10-13" version="1">MAPAPSSEPYGIGHGVANSLLRRDLSSPTHTQQVTLGIIAVYVVVIAILWNVPYVRMVLWPFKMLVIAFHEFGHAITAVLTGGKVKSISLDPNEGGVTHMIGGKSAITLPAGYLGSSIIGALLIFCGFNIVASKVASIVLGVCFLLTLWWGKRDWLTILTILLAVGLLIACWFISHAQALRFVVLFIGVMSSLYSVWDICDDLILRKVNSSDASVFAKRYGGSSQCWGVIWSIISVCFMAAGIVAGLAAFSQSFEQQEKDSQKFIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8P7</accession>
    <name>C7Z8P7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotransferase class V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_94344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045115.1">
        <property type="nucleotide sequence ID" value="XM_003045069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8P7"/>
    <dbReference type="STRING" id="660122.C7Z8P7"/>
    <dbReference type="GeneID" id="9673614"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94344"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94344"/>
    <dbReference type="eggNOG" id="KOG1549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_3_0_1"/>
    <dbReference type="InParanoid" id="C7Z8P7"/>
    <dbReference type="OMA" id="VCIFDVV"/>
    <dbReference type="OrthoDB" id="5978656at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092:SF2">
        <property type="entry name" value="HERCYNYLCYSTEINE SULFOXIDE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092">
        <property type="entry name" value="L-CYSTEINE DESULFHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="68"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU39402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="441" mass="49571" checksum="8514263071AACFA9" modified="2009-10-13" version="1">MGSVTQELPLRGKPSASVFGAAMKDEFLFDPEWRNLNHGSFGTYPKAIKAKFRDEARPDVFIRYEYPKLLDESRVAVAKILNAPEDGVVFVSNATVGVNTVFRNMAWNKDGKDVIISFSTIYEACGKVADYLADYYEGNVTHREIEITYPIDDDVILKRFEDTVKKIEEEGKRARICTFDVVSSRPGVVFPWEEMIKTCRRLNVLSMVDGAQGIGMVKLDLSAADPDFFVSNCHKWLHVPRGCAVFYVPQRNQALLPTTLATSHGYVPKLANRISPLPPSSKPRFVTNFEFVGTLDNSPYLCVKDAIKWRQDVLGGEDAVLKYLWDLNKKGTDIVAKALNTPVMENSTGTLRNCGMGNVALPLWAGEGEGTVVPADETQKAFQWMLTTLIDDYKTFLSLFIHGGRFWARISAQVYLGIEDYEWAGKVLKELCERVAKKEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8Y7</accession>
    <name>C7Z8Y7_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_81674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044770.1">
        <property type="nucleotide sequence ID" value="XM_003044724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8Y7"/>
    <dbReference type="STRING" id="660122.C7Z8Y7"/>
    <dbReference type="GeneID" id="9673680"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_81674"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_81674"/>
    <dbReference type="eggNOG" id="ENOG502T43H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_858045_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z8Y7"/>
    <dbReference type="OMA" id="TEDSDYW"/>
    <dbReference type="OrthoDB" id="5041951at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="348" mass="39493" checksum="4B34BF90D5CFE448" modified="2009-10-13" version="1">MSSRQTPASHLAQDGPSTESILAMLRTPRDEVYTLSQDGNTYIRPQCLRDTPVAKLTENSPYWRSTWHSLDEYLAQEEEEERLKKETGARLKLDPSNKSVAAAHKLHQDNVSKHRRIRDIFGPNTRYHPNQLVAKHHLPDDGLCQKEIMYRLACKISDLRVLHEKNELAMDPWDFMRWRISKKILSFIPFPGSSARDNIRTIVYKICEDCGSSPNMKQYEDVLLRAAILRSANYQNRIASFTTKGDKIKAGSSGSAQPRSRVASGGRPRTGSFSSVVSNTSSRPRTGSFSNAASNTSSRPTLPPPRVDKHRPQPSAYMGINAWREQKRRQEAEKNKESNQDSNKESEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9U3</accession>
    <name>C7Z9U3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">L-type lectin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_62153</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045275.1">
        <property type="nucleotide sequence ID" value="XM_003045229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9U3"/>
    <dbReference type="STRING" id="660122.C7Z9U3"/>
    <dbReference type="GeneID" id="9672055"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_62153"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_62153"/>
    <dbReference type="eggNOG" id="ENOG502QR1C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053733_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z9U3"/>
    <dbReference type="OMA" id="WSAEFQF"/>
    <dbReference type="OrthoDB" id="10265193at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06903">
        <property type="entry name" value="lectin_EMP46_EMP47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035661">
        <property type="entry name" value="EMP46/EMP47_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF28">
        <property type="entry name" value="LECTIN, MANNOSE BINDING 1 LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988646" description="L-type lectin-like domain-containing protein" evidence="9">
        <location>
            <begin position="19"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="10">
        <location>
            <begin position="25"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="240"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="252"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU39562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="434" mass="48242" checksum="48DB2C30EEE071C9" modified="2009-10-13" version="1">MRFSLSLAALLAAGLSEAQYLISELSFGHAGRISPPESRGEIPNFALQGIPQMPEVLSNRIILTPLAPGNQRGAVWGQQPLLRNQWIADFDFRANGPDRGRGNLNIWLVRNGPASVGSGSIYTVGKFDGLALVVDTHGGAGGMVRGFLNDGTVDFTRQNNVDELSFGHCGYNYRNLGRPSQIKLRQTSTSFRVEVDGNLCFESGSFSIPTGYQFGVTAATPDNPDSFEVFKVVVMADNSDSAPVRNNDPPKKQQQQQQTPNKSPPSRGAPPKRETAEGDYADEDPDIFQTSKTQFMDLHNRLQNTNHQLSSLHRTSSRHQQEDVKRHEEVTNLIGQLRADMRKLDDITALQTRVIELEKEVKGLRKDLTRKLQSTERSVRDVLSSHHNSLSQAVMASTPGHRFLVLFFLGTQLALVAAYVIYKRRRDTMPKKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9X1</accession>
    <name>C7Z9X1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase MRP protein 1 RNA binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_81900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045289.1">
        <property type="nucleotide sequence ID" value="XM_003045243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9X1"/>
    <dbReference type="STRING" id="660122.C7Z9X1"/>
    <dbReference type="GeneID" id="9672069"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_81900"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_81900"/>
    <dbReference type="eggNOG" id="ENOG502S2QW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031977_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z9X1"/>
    <dbReference type="OMA" id="RAKWMMR"/>
    <dbReference type="OrthoDB" id="5414547at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000294">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, RNase MRP-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047205">
        <property type="entry name" value="RMP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047204">
        <property type="entry name" value="RMP1_RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37792">
        <property type="entry name" value="RIBONUCLEASE MRP PROTEIN SUBUNIT RMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37792:SF1">
        <property type="entry name" value="RIBONUCLEASE MRP PROTEIN SUBUNIT RMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20945">
        <property type="entry name" value="RMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase MRP protein 1 RNA binding" evidence="2">
        <location>
            <begin position="24"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU39576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="250" mass="27319" checksum="A477283480A1B977" modified="2009-10-13" version="1">MTSPHPSAALLSTANESLAPVLPILNAFAHRHRNQHHSSHWWSSFSLVRRAARNLSTDLTSRPRPIKSKNKPGNVEGDNHPALARAKWMIRHVVPRTYIAFSQLAADNQHAPLGLLLLSILARINRILSDLVPADQNTIPTASAPTKPTTTGPILSSNYQTSTPAETDSPDIDMGVTISRNEVLPIRKTTTSQPETKPDAHLTDPPPKERKLKSLTKDTKKTSSKDPAKDKPKKKKKKGGDALSSLFGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZA69</accession>
    <name>C7ZA69_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_43285</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045339.1">
        <property type="nucleotide sequence ID" value="XM_003045293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZA69"/>
    <dbReference type="STRING" id="660122.C7ZA69"/>
    <dbReference type="GeneID" id="9672294"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_43285"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_43285"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_7_1_1"/>
    <dbReference type="InParanoid" id="C7ZA69"/>
    <dbReference type="OMA" id="LSWWFIP"/>
    <dbReference type="OrthoDB" id="10054429at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF13">
        <property type="entry name" value="THIAMINE TRANSPORTER THI9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU39626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="53965" checksum="FBDFC507420DE035" modified="2009-10-13" version="1" fragment="single">VLHRSFNQFHNFATTFAALYFIGGVRVTFSTGIAAGGNLAYWTSYIVTCVFTFITAAVIAEICSSLPLAGSIYLWAAEAGGPRFGRLFGFVVAWWSTTAWTTFCASNTQAAVNYMLSEIVVFNTDFPSDSTSVKFRAVQWICTEVMLALAAIWNLLPPRYFKWIFTLSSSVVVLDFVLNLIWLPITTSKTIGFRSTHDAFMTTYNGTGAPPAWNWCLSYLATAGILIGFDASGHVAEETKNASVAAARGIFWSTVVSGLGGFAVVILFLFCVPDAETLFSFGGAQPFVSVYAAILGEGGHIVMNIVCVMALWFNTAIAVLAASRLVFAVARDGVLPWSSWTSRVVAGQPRNAVLVVWGVAAVITCTILPSSVAFTSLVSAAGVPSAAAYGLICLARLFLTPKNFPKPAWSLGRLSKPFQVIAVFWNGWVVAVLYSPYIFPVSGETLNYAPVIMGGTTILALLSWWFVPADRWLPSQRIQQTLDADKHARQQTEAQSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZA90</accession>
    <name>C7ZA90_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_82015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045349.1">
        <property type="nucleotide sequence ID" value="XM_003045303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZA90"/>
    <dbReference type="GeneID" id="9672304"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82015"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82015"/>
    <dbReference type="eggNOG" id="ENOG502RP6G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1166108_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZA90"/>
    <dbReference type="OMA" id="WVASMVI"/>
    <dbReference type="OrthoDB" id="5106854at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU39636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="238" mass="26165" checksum="0E9F7F9B908001E1" modified="2009-10-13" version="1">MVNSADNMTCILPRRWLLLLPTPIKAHSRPSPDNDPLTPLLLEKGLLLSPASHDDEMGCATQFTKKTLPMALALPWVASMLMSWIPFTKIGLSEAPTFLTLAAGVSTLEVLSIIAVFIYTSLSPAALNAEPVENGRSSTLQEKFLRAWFWFLFVSPLVSSIVVVLMASDISCDEDEILDVHQPICKVGIRLIKATALFRAAIIAIFLFAMSSWLDSKSPKSIELKSPRKPSNDTPRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAA5</accession>
    <name>C7ZAA5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_70543</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044954.1">
        <property type="nucleotide sequence ID" value="XM_003044908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAA5"/>
    <dbReference type="STRING" id="660122.C7ZAA5"/>
    <dbReference type="GeneID" id="9672136"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_70543"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_70543"/>
    <dbReference type="eggNOG" id="KOG0069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZAA5"/>
    <dbReference type="OMA" id="VQMAEYV"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12160">
        <property type="entry name" value="2-Hacid_dh_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333">
        <property type="entry name" value="2-HACID_DH_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="3">
        <location>
            <begin position="103"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU39241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="314" mass="34057" checksum="91B5838EE4B1D7CD" modified="2009-10-13" version="1">MKLLYPTSLKLDVPSLEGFSVELKPYDVKKPIPEDLIDAEALVTWTNSAENLKDAAARMKNLRWIQSLAAGPNDVLSAGFDTSKITVTTGSGLHDRTVAEHALGLLLNAARRFYEMRDYQLQGKWPGHLGGPQPDRPAGAFTTLRDARVLIWGFGNIAKTLTPHLLGLGAEVRGIARRRGVRDGIEVYGEDSLAELLPETDALVMILPGSDSTRHALNAERLKLLPKHAWVVNVGRGTSIDEDALVDALEKGEIGGAALDVFETEPLPEPSKLWKAPNVIVSPHAAGGRPQGSEGLIADNLRRLRAGQELKNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAY4</accession>
    <name>C7ZAY4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">NECHADRAFT_83060</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044387.1">
        <property type="nucleotide sequence ID" value="XM_003044341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAY4"/>
    <dbReference type="GeneID" id="9670809"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83060"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83060"/>
    <dbReference type="eggNOG" id="ENOG502SFDE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126663_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZAY4"/>
    <dbReference type="OMA" id="NSISCCV"/>
    <dbReference type="OrthoDB" id="3065412at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF2">
        <property type="entry name" value="GPI ANCHORED CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G10580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002989084" description="CFEM domain-containing protein" evidence="17">
        <location>
            <begin position="18"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="18">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="90"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="90"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="24"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="47"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEU38674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="202" mass="19461" checksum="D4484673763FECED" modified="2009-10-13" version="1">MKSVLIAAVLASAGALAQSPLPSCAQSCALNILASSGCGSTDVACVCKSKVFVEGYTSCVTKACSSEDAAKAEQYGVQLCGSAGVSVGGEAPATEAPAASSEAPSAPSTPTEAPSAPSAPAVPSAPEAPSAPSAPSPPYPPKPSEEVPPVVPPESKPAEVPTAPATPATPTAVVPTAGAGIVQVSNAVILSVGLSMMLVLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZB09</accession>
    <name>C7ZB09_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_45887</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044423.1">
        <property type="nucleotide sequence ID" value="XM_003044377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZB09"/>
    <dbReference type="STRING" id="660122.C7ZB09"/>
    <dbReference type="GeneID" id="9672726"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45887"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45887"/>
    <dbReference type="eggNOG" id="KOG1290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_81_1_1"/>
    <dbReference type="InParanoid" id="C7ZB09"/>
    <dbReference type="OMA" id="HTSLVHR"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="68"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU38710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="412" mass="46739" checksum="B2D41F296DE85D3A" modified="2009-10-13" version="1">MASTWSKLASSLGRLRQGQKTPEEPRSLPTSGFSLIDQSQKVEEEELPDYVADRFYPVRLGEVFHGRYQTIAKLGFGSSSTIWLARDLNDHPYVALKVYVHTSRFHRELPLYKDMDQKLSTTENPGRKNIRQLLDSFNIDGPHGQHVALVFQPAQMSLRDMKLVFRKDGGFDEMFVKGAVEELLKALDFLHNEAHVVHTVDVHSGNLLLGLNDDSILRPLEDQEFSSPVARKGVSPDRTIYLSRLMRPKPGPMLLSGFGEARSGPGPHAGDIMPIQYRAPETIMCISWSYPVDIWSVGLTAWDLLGPKRLFTAQDEDGDMYDAAHLAQLIAALGPPPLEFLRRNPERAADFWDKNGNWLGLAPIPPNRTLEELETRLKDPSRFIAFLRRVLTWVPEERPTAKELLQDPWLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZB93</accession>
    <name>C7ZB93_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_6775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044368.1">
        <property type="nucleotide sequence ID" value="XM_003044322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZB93"/>
    <dbReference type="STRING" id="660122.C7ZB93"/>
    <dbReference type="GeneID" id="9672868"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_6775"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_6775"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_6_3_1"/>
    <dbReference type="InParanoid" id="C7ZB93"/>
    <dbReference type="OMA" id="FPEAIHT"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="22"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU38655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="270" mass="29715" checksum="8DE7C83B9E27D14B" modified="2009-10-13" version="1" fragment="single">RDGHVHEVGVYKPESLATGALVVLIHGGGFCLGHYSHISFYSRALIALYDVTVVNIAYRLAPEFPFPTAPQDVWDSLGALTSSTVAEELGLDLSRGFFIGGTSAGANLAAVAVQQWTTQELSPPILGVWLDIPMIFDAAIVPEEQKALWLSRKQNANAMVINAKSREYVYRVYKPDIRSPDFSPFNSPNPHTGFPPVYIQVCGQDPLRDDGLVYERVLREHGVKTRLDAYPGVPHGSANLFPTLTSSKKHQVDVLQGFGWLLGREARDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBF0</accession>
    <name>C7ZBF0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">NECHADRAFT_7448</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Dual chitinase/transglycosylase that plays a role in cell wall architecture. Chitinase and transglycosylase activities are coupled. Required for the polysaccharide cross-linking at the septa and the cell wall. More specifically, transfers chitin to 1,6-beta-glucan in the cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044556.1">
        <property type="nucleotide sequence ID" value="XM_003044510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBF0"/>
    <dbReference type="STRING" id="660122.C7ZBF0"/>
    <dbReference type="GeneID" id="9672744"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_7448"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_7448"/>
    <dbReference type="eggNOG" id="ENOG502QQ71">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027506_3_0_1"/>
    <dbReference type="InParanoid" id="C7ZBF0"/>
    <dbReference type="OMA" id="DDDNWEG"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000152">
        <property type="entry name" value="Cell wall glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF68">
        <property type="entry name" value="GLYCOSIDASE CRH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GH16" evidence="15">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="243"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="268"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEU38843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="283" mass="30336" checksum="FA71569CD52558DD" modified="2009-10-13" version="1" fragment="single">AGLIASATAQTYSDCNPMEKSSCSADEALSSSSYSVDFTKGADDDAWESIGSGDVDYTSKGAEFTINEKGDAPTIQTNWYIFFGRLEVHLKAASGTGIVSSAVLLSDVLDEVDWEWLGGSSEEVQTNYYGKGNSTSDTRSETLAAAGSQTASHNYTIYWTKETCVWYVDGTAVRTLNYADALGGENYPQTPMRIKLGIWAGGDSDNAEGTITWAGGETDYSDAPFTMIVESVKIENFNPAESYTYGDQTGDYGSIELDETDKSETKSKTSTKTTTSTGSSTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCH7</accession>
    <name>C7ZCH7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="10">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_77056</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 13">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="GG698918">
        <property type="protein sequence ID" value="EEU38371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044084.1">
        <property type="nucleotide sequence ID" value="XM_003044038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCH7"/>
    <dbReference type="GeneID" id="9670409"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77056"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77056"/>
    <dbReference type="eggNOG" id="ENOG502SH94">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014819_3_2_1"/>
    <dbReference type="InParanoid" id="C7ZCH7"/>
    <dbReference type="OMA" id="RYTISFC"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF15">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU38371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="458" mass="49588" checksum="AE2DC762069F64B7" modified="2009-10-13" version="1">MSPDLQVTCVASFFPIPTLFGAEIYSLNATWTKNYSYEIDQGRYASSHAFSVQGLNFCNVSIWYIHPGYDDHVNVQVLLPERWNGRFQGTGGGGFVIGLSEPAMVGGMTQGYAVASSDGGHKTTATEEWVLKSPGNINWPNVFNFGSTSLYDFTIIGKQATTAYYGKPPEYSYFTGCSTGGRQALALAQRWPELYDGILSGAPGINYAELATWILYPIMNWSGEYPQLCETTAITRAAIEACDHLDGAVDVALAAWTGARSINGTLLWHGLAKDAPLSGLANTTCDYQGSGECSGVPYAIAKDWIQYFIYKGLSSTMSPMNNTYASSLGTTDPDVRGVRENGGKILTRHGVADQLVPINGTRQYYEIATAIDPNITDYFRYSEAPGVYHCRGGVGPCPGDILAKLVGWVEKDSVPETLAAKSLPNDKGVSIERDLCPHPKVQKYKGGDLTKGSSHECV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCM3</accession>
    <name>C7ZCM3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_34566</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698918">
        <property type="protein sequence ID" value="EEU38288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044001.1">
        <property type="nucleotide sequence ID" value="XM_003043955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCM3"/>
    <dbReference type="GeneID" id="9670431"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_34566"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_34566"/>
    <dbReference type="eggNOG" id="KOG4157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014722_3_1_1"/>
    <dbReference type="InParanoid" id="C7ZCM3"/>
    <dbReference type="OMA" id="DRVSFAC"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF3">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002986992" description="WSC domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="372"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="488"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="596"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="704"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU38288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="899" mass="95437" checksum="3692CCC5E8590A73" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCQ0</accession>
    <name>C7ZCQ0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ecp2 effector protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_91512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698918">
        <property type="protein sequence ID" value="EEU38407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044120.1">
        <property type="nucleotide sequence ID" value="XM_003044074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCQ0"/>
    <dbReference type="STRING" id="660122.C7ZCQ0"/>
    <dbReference type="GeneID" id="9670445"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_91512"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_91512"/>
    <dbReference type="eggNOG" id="ENOG502SHR0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084275_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZCQ0"/>
    <dbReference type="OMA" id="TWYADSH"/>
    <dbReference type="OrthoDB" id="4831122at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988716" description="Ecp2 effector protein domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="28769" checksum="BD19F73D879AC92B" modified="2009-10-13" version="1">MYHLGLVGLFLASVAGAMPLEAGAETFPGAVKWTSGYEIKSIDVIVPVDGVEYVVKEDVYLASLKAAGIKIGAPELDPSWVSYNASDIPDLEDVEAAEGGHKKRASCDNTNYIVTDKTETFVDWDMQMSPVVCAVGDMDISVSSGYSISNTVGGSAGVDIKFVKDRLGSSLGINYSRTWTTQTSVITKGTVKNGNCGVMITKPITTRRSGRQFRGCIGSARQIGTWYADSRKDGSYNGIKWIEGAISMCVKRGNNPPLSRCHGQGNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCS2</accession>
    <name>C7ZCS2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Epoxide hydrolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_48156</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698919">
        <property type="protein sequence ID" value="EEU38092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043805.1">
        <property type="nucleotide sequence ID" value="XM_003043759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCS2"/>
    <dbReference type="GeneID" id="9670260"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_48156"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_48156"/>
    <dbReference type="eggNOG" id="KOG2565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019414_0_2_1"/>
    <dbReference type="InParanoid" id="C7ZCS2"/>
    <dbReference type="OMA" id="SSARWYW"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="5">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU38092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="409" mass="46795" checksum="4EA137E99CD66740" modified="2009-10-13" version="1">MSDIKPYQIHVSDFRVDRLNQKLALTDFPSQNYDPTSASWKLGPPVNEIERLARVWQSSFDWRQVEARLNQLPQFTVPIETADFGAFDVHFVHKQSSQAHAIPLLFLHGWPGSFYEVSKIIDPLVQGESHEDQVFHVVAPSLIDFGFSSPSKVCGFEFEHHADVYDKLMQKLGYDRYVIQAGDVGCLVMRYMAKLYGPSRCMACHTNTPVPREPTKDTHPELHAKTSATQLTETEQKALERTGVFYNEGSGYYKLQSTRPFTIGYSLRDSPVGLLAWIYEKLREWSDDYPWSDEDILTWVSIYYFSTPGPEATSNVYYAIEHGELPAFAVAAEYMDVPLGISRFSNDLVLLPKLWNQTLGPIMYEADHAKGGHFAAWERPDAIVQDLRAMFELFKHGRETYVDGMRKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDR4</accession>
    <name>C7ZDR4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">L29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_73956</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043509.1">
        <property type="nucleotide sequence ID" value="XM_003043463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZDR4"/>
    <dbReference type="FunCoup" id="C7ZDR4">
        <property type="interactions" value="1004"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZDR4"/>
    <dbReference type="GeneID" id="9669729"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_73956"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_73956"/>
    <dbReference type="eggNOG" id="KOG1742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109163_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZDR4"/>
    <dbReference type="OMA" id="WGRVGQH"/>
    <dbReference type="OrthoDB" id="61900at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="8">
        <location>
            <begin position="72"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00080124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU37796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="149" mass="16809" checksum="706AF93767B687AD" modified="2009-10-13" version="1">MPTRLSKTRKHRGHVSAGKGRVGKHRKHPGGRGLAGGQHHHRTNMDKYHPGYFGKVGMRYFHKQQNHFWKPIINLDKLWSLVPVETRDAYVSGEKKDTVPVLDLLPLGYSKVLGKGRLPEIPLVVRARWVSRLAEKKITEAGGVVELVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEH2</accession>
    <name>C7ZEH2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phenylacetate 2-hydroxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_102133</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Aromatic compound metabolism; phenylacetate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698921">
        <property type="protein sequence ID" value="EEU37697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043410.1">
        <property type="nucleotide sequence ID" value="XM_003043364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEH2"/>
    <dbReference type="STRING" id="660122.C7ZEH2"/>
    <dbReference type="GeneID" id="9669295"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102133"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102133"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_4_1"/>
    <dbReference type="InParanoid" id="C7ZEH2"/>
    <dbReference type="OMA" id="DPRAYWQ"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11066">
        <property type="entry name" value="CYP_PhacA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000072">
        <property type="entry name" value="3-hydroxyphenylacetate 6 hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF9">
        <property type="entry name" value="P450, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU37697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="57782" checksum="F9580BFCBD837917" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEI1</accession>
    <name>C7ZEI1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Terpene cyclase/mutase family member</fullName>
            <ecNumber evidence="7">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_53474</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the terpene cyclase/mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="7"/>
    <dbReference type="EMBL" id="GG698921">
        <property type="protein sequence ID" value="EEU37600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043313.1">
        <property type="nucleotide sequence ID" value="XM_003043267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEI1"/>
    <dbReference type="FunCoup" id="C7ZEI1">
        <property type="interactions" value="135"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZEI1"/>
    <dbReference type="GeneID" id="9669299"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_53474"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_53474"/>
    <dbReference type="eggNOG" id="KOG0497">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009074_2_1_1"/>
    <dbReference type="InParanoid" id="C7ZEI1"/>
    <dbReference type="OMA" id="YRYRHIS"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000250">
        <property type="term" value="F:lanosterol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02892">
        <property type="entry name" value="SQCY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000003">
        <property type="entry name" value="Terpene cyclase/mutase family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002365">
        <property type="entry name" value="Terpene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764:SF20">
        <property type="entry name" value="LANOSTEROL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="TERPENE CYCLASE/MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01074">
        <property type="entry name" value="TERPENE_SYNTHASES"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Squalene cyclase N-terminal" evidence="10">
        <location>
            <begin position="89"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene cyclase C-terminal" evidence="9">
        <location>
            <begin position="392"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU37600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="738" mass="84266" checksum="394F29A482786A78" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZER0</accession>
    <name>C7ZER0_FUSV7</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_97068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043133.1">
        <property type="nucleotide sequence ID" value="XM_003043087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZER0"/>
    <dbReference type="GeneID" id="9665361"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_97068"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_97068"/>
    <dbReference type="eggNOG" id="ENOG502RE1J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008240_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZER0"/>
    <dbReference type="OMA" id="VENELMY"/>
    <dbReference type="OrthoDB" id="3235083at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU37420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1140" mass="123952" checksum="463723F8033992E4" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEW5</accession>
    <name>C7ZEW5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_86321</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
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        <property type="protein sequence ID" value="EEU37376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043089.1">
        <property type="nucleotide sequence ID" value="XM_003043043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEW5"/>
    <dbReference type="GeneID" id="9665286"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86321"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86321"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_4_2_1"/>
    <dbReference type="InParanoid" id="C7ZEW5"/>
    <dbReference type="OMA" id="TSMIPAC"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="457"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU37376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="56501" checksum="FDD649E90FAB92C1" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFD7</accession>
    <name>C7ZFD7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_78471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698923">
        <property type="protein sequence ID" value="EEU37227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042940.1">
        <property type="nucleotide sequence ID" value="XM_003042894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFD7"/>
    <dbReference type="STRING" id="660122.C7ZFD7"/>
    <dbReference type="GeneID" id="9665081"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78471"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78471"/>
    <dbReference type="eggNOG" id="ENOG502RZSA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036110_1_3_1"/>
    <dbReference type="InParanoid" id="C7ZFD7"/>
    <dbReference type="OMA" id="PIYGSKQ"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052988">
        <property type="entry name" value="Oryzine_lactonohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064:SF2">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="1">
        <location>
            <begin position="148"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="333" mass="36434" checksum="EE43FECC1F69BE9F" modified="2009-10-13" version="1">MPSQATIVASRQSPVATHLTPMTDPANIWRIFQDEFRDILGEEPSLQLLLQIDEFPFAHEAGVFLPKANELFITSNQFKDHAGEKTVQISKISLSSDSDSVKLQKISCELIHMANGGVNYQDGILICAQGSATHPSGLFKLQTTYPYEAKPVITSYMGRPFNAVNDVVVHSDGSIWFTDPSYGHDQGYRPRPSLPNAVYRYDPVTESIRAVADGLGRPNGICFSPDYSTVYITDTDQRHGQPFLTNKRLFALASTGIPDGIKCDTRGNVYSGCGDGINIWSPGGVLLGKIIIPGGVANFCFGSEGQILALNEHRLWRVQLDKCVRGALLDGQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFH2</accession>
    <name>C7ZFH2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_78322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698923">
        <property type="protein sequence ID" value="EEU37150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042863.1">
        <property type="nucleotide sequence ID" value="XM_003042817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFH2"/>
    <dbReference type="GeneID" id="9665140"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78322"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78322"/>
    <dbReference type="HOGENOM" id="CLU_1741039_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZFH2"/>
    <dbReference type="OrthoDB" id="5101140at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU37150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="150" mass="16857" checksum="3490C765871A3AD0" modified="2009-10-13" version="1">MSHNPRTTGDDESDTYSELNRAAVLLKEAEDFEALKLPPVATRSGAPEEALWRVLEFLRVTTFGLNRDLSHPDSTVVLSGKTRSDYPEGERQKELVFKAGMLLWTCSMVRDLIVELSEIYVPGKDLSSIGEIIALLKKHIPVLEKDAKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZG73</accession>
    <name>C7ZG73_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_52245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698924">
        <property type="protein sequence ID" value="EEU37114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042827.1">
        <property type="nucleotide sequence ID" value="XM_003042781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZG73"/>
    <dbReference type="STRING" id="660122.C7ZG73"/>
    <dbReference type="GeneID" id="9664860"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_52245"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_52245"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_138_0_1"/>
    <dbReference type="InParanoid" id="C7ZG73"/>
    <dbReference type="OMA" id="ITRIHIG"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="22"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="301" mass="34124" checksum="4F4802DD07911667" modified="2009-10-13" version="1" fragment="single">MRLINVRTMELEEFHGDQVPWYAILSHTWGQGEVTFQDWKDPNLASQKAGFAKILGACQQAREDSLEYLWVDTNCIDKSSSAELSEAINSMFAWYRDAVVCYAFLIDVPTIPTSGQDRFTGFCKSRWFTRGWTLQELLAPKEVIFFDQNWQKVGTRSGSLGERISAITQINVHIITDPSTMIHASVAQKMSWLSRRVTTRVEDMAYCMLGIFDINMPLLYGEGRNAFLRLQEEIVKISTDHTIFCWNWVESVPGSWTSMLAPTPAAFESSGCYVEPIRDASSPELSPYSFTNAGLSIRLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZGT9</accession>
    <name>C7ZGT9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YCII-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_55699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698926">
        <property type="protein sequence ID" value="EEU36772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042485.1">
        <property type="nucleotide sequence ID" value="XM_003042439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZGT9"/>
    <dbReference type="GeneID" id="9669808"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55699"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55699"/>
    <dbReference type="HOGENOM" id="CLU_3112018_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZGT9"/>
    <dbReference type="OMA" id="ADREDMW"/>
    <dbReference type="OrthoDB" id="5519740at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1060">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU36772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="51" mass="5945" checksum="D9982223225A596D" modified="2009-10-13" version="1" fragment="single">PQITGSAMLVFASRRDDVVARLKDDPLVKERVWDLENAQIYPFFRPRRSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZH07</accession>
    <name>C7ZH07_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gfo/Idh/MocA-like oxidoreductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_51937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698927">
        <property type="protein sequence ID" value="EEU36729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042442.1">
        <property type="nucleotide sequence ID" value="XM_003042396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZH07"/>
    <dbReference type="STRING" id="660122.C7ZH07"/>
    <dbReference type="GeneID" id="9669682"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51937"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51937"/>
    <dbReference type="eggNOG" id="KOG2741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2090532_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZH07"/>
    <dbReference type="OrthoDB" id="446809at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU36729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="117" mass="13200" checksum="6193204F81E616D8" modified="2009-10-13" version="1" fragment="single">DNAIGMMEFHDDRMVSLFASRTMAADAEDSTEIIGTKGKLVVNMMPRVNHVHVYQTGVVLQEMPQNYWERFQDAFVTQANRFAETVLDDKPSRIELESAVEVAKIGVALQERGKDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHQ2</accession>
    <name>C7ZHQ2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_94120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698928">
        <property type="protein sequence ID" value="EEU36456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042169.1">
        <property type="nucleotide sequence ID" value="XM_003042123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHQ2"/>
    <dbReference type="STRING" id="660122.C7ZHQ2"/>
    <dbReference type="GeneID" id="9669347"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94120"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94120"/>
    <dbReference type="eggNOG" id="KOG0069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_2_1"/>
    <dbReference type="InParanoid" id="C7ZHQ2"/>
    <dbReference type="OMA" id="IPYYPFD"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000203">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase (SerA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF129">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE C1773.17C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="31"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="130"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU36456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="345" mass="38479" checksum="B801FBFB83EB7419" modified="2009-10-13" version="1">MSLAPKSERKPRVVCLGKPKFIGDDYLKEFQKDFDYDVLDVTNHQQAMEQLPLMIAEHGPIDAFVIRMGRPPFRPFNEKLFGPLTPHCRIIASASAGYDDFDLDWLTQNNIYLSNTIDAVAEATADMSFFLTLAVIRDAYRGERDARNGTWNRIVVPSRDPTGMTLGIIGMGTIGKYVAKRAAVFNMKIKYYNRRQLSPEDEAKYSASYCSSLNELLAESDVVSVNCPLNKETTNLISAKEFAMMKDGAFIVNTARGPIINEDALIEALESGKITRAGLDVFLGEPNINDYFRKSDKVVIQPHIAGLTDLSFQKGEREAFDNIKALFKTGKPLSPVNEIKSTQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHQ3</accession>
    <name>C7ZHQ3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_94121</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698928">
        <property type="protein sequence ID" value="EEU36457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042170.1">
        <property type="nucleotide sequence ID" value="XM_003042124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHQ3"/>
    <dbReference type="GeneID" id="9669348"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94121"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94121"/>
    <dbReference type="eggNOG" id="KOG2820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_2_1_1"/>
    <dbReference type="InParanoid" id="C7ZHQ3"/>
    <dbReference type="OMA" id="SQTRLCW"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF15">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="11"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU36457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="464" mass="50381" checksum="E684707666A49689" modified="2009-10-13" version="1">MSTPPAKADAIIIVGAGIFGLSTAIHLARRGYTNVTVFDKQPYEKTLYSYTEGCDAASADINKIIRSAYGAQTEYQGLSAEALKAWDSWNAELKAGGSSVPPGMTSNDVVWINNGFLSLSNSTTLPDFERATVDNMEAAGQKGTQLINNDENHLRLAAEKGRTSAMQPFSKKALGVLDTTGGIAVADKACLFALHKAKSLGVRFILDPAAGRLISTIQDANGKVTGIRTGDGKSHSSIITIIAAGGWTPTLVPSLDNLAETTAGSVIILKIPESSPLRERFSPSRFPSFSFNMREGAEGGIYGFPVDEHGHLKIGYRGTKYTNPKVQADGRERSEPVTRWTEKEQITKIPEQALRVLRKFLAEYLPELEAEGIDIWLTRLCWYNDSFDNHYVIDRVPGQESLVVATAGSGHAFKYLPNIGNWAWRWREKQPGQEVVNSLMEGSKGERALGNIPLVSADVSSSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZI29</accession>
    <name>C7ZI29_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_97427</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698929">
        <property type="protein sequence ID" value="EEU36328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042041.1">
        <property type="nucleotide sequence ID" value="XM_003041995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZI29"/>
    <dbReference type="GeneID" id="9674378"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_97427"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_97427"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012970_2_2_1"/>
    <dbReference type="InParanoid" id="C7ZI29"/>
    <dbReference type="OMA" id="LAPKPMM"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF58">
        <property type="entry name" value="LOW AFFINITY HEME TRANSPORTER STR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="40"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU36328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="604" mass="65876" checksum="780163F80674DA8C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZI61</accession>
    <name>C7ZI61_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alanyl-transfer RNA synthetases family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_86981</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698929">
        <property type="protein sequence ID" value="EEU36401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042114.1">
        <property type="nucleotide sequence ID" value="XM_003042068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZI61"/>
    <dbReference type="FunCoup" id="C7ZI61">
        <property type="interactions" value="251"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZI61"/>
    <dbReference type="GeneID" id="9674384"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86981"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86981"/>
    <dbReference type="eggNOG" id="KOG2105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004485_7_1_1"/>
    <dbReference type="InParanoid" id="C7ZI61"/>
    <dbReference type="OMA" id="KYDTTSW"/>
    <dbReference type="OrthoDB" id="288942at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002196">
        <property type="term" value="F:Ser-tRNA(Ala) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051335">
        <property type="entry name" value="Alanyl-tRNA_Editing_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462:SF1">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN AARSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU36401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="434" mass="46865" checksum="C947C3F55E0662A3" modified="2009-10-13" version="1">MAVTESVSTGRVVGALACQSDSYLKTLDTEVVSCVKAPAEPSKGSKKKKQEAAPQDEWLIECADSVLFPEGGGQPSDHGTITLLSGSDQTPISIKNVQRHGLRCVIYSPQPLSPGDKIRQEVDWARRWDHMQQHTGQHLLSAIMMNDHGLKTLGWGMGAAGTMNYVDIPRKPTEEEMQSIQSRCSELIRDNLSIKVETPDDAKHEKLPGDYDKSEGVVRVIHIGDIDINTCCGTHLSQTSHVSLVILGSTQSVHGKNCRLSFMTGDRAVSLANASVGAVGSIAKLMSSSSVPTEVLAKTSTMCDTVTELRRVERKLMLEIAKYESDRVNAVIRGGKNAYVYRSDGGMDFINKIVGETKEAAQGTGHVVVFAIGESKSTGPVVIVGDKEAVEDMATKVKGMVKDIKGGGGAGKWQGKVKEWQKSELAALKELVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZI84</accession>
    <name>C7ZI84_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Maltase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_52845</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="GG698930">
        <property type="protein sequence ID" value="EEU36215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041928.1">
        <property type="nucleotide sequence ID" value="XM_003041882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZI84"/>
    <dbReference type="FunCoup" id="C7ZI84">
        <property type="interactions" value="893"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZI84"/>
    <dbReference type="GeneID" id="9674342"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_52845"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_52845"/>
    <dbReference type="eggNOG" id="KOG0471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_1_1_1"/>
    <dbReference type="InParanoid" id="C7ZI84"/>
    <dbReference type="OMA" id="HATRFAN"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11333">
        <property type="entry name" value="AmyAc_SI_OligoGlu_DGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000064">
        <property type="entry name" value="Oligo-1,6-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000087">
        <property type="entry name" value="Oligo-1,6-glucosidase IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000003">
        <property type="entry name" value="Probable alpha-glucosidase (Maltase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF222">
        <property type="entry name" value="MALTASE MALT (AFU_ORTHOLOGUE AFUA_8G07070)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="9">
        <location>
            <begin position="26"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU36215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="604" mass="69874" checksum="DF159917424E7353" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZIR1</accession>
    <name>C7ZIR1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase S33 tripeptidyl aminopeptidase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_87232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698931">
        <property type="protein sequence ID" value="EEU36072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041785.1">
        <property type="nucleotide sequence ID" value="XM_003041739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZIR1"/>
    <dbReference type="GeneID" id="9674232"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87232"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87232"/>
    <dbReference type="eggNOG" id="ENOG502QXCY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1061350_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZIR1"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="1">
        <location>
            <begin position="194"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU36072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="294" mass="32375" checksum="CC761B7BF7EDF2E9" modified="2009-10-13" version="1">MTGPLMDHLDTIQVVKDLEAVRAALGNEKMNWLGMSYGTMIDTQYDEASMLLSEATTYETTLKRFFNWFETGNKPTCVLSGRNVENIGKIFLLKQPRSPSRHLGAAQFAGQTSTPRRFALEHRFSYSKLQLDATEGDATALSTYLATGDAFGDSMLFTFLATTCNDFPTEAEAFADLWVKQIEASVFAPLTGGASATYMVQSACIGWKHKNRNRPKMVKIRGTPKVLVVNGIYDPSTSYAWAMGVSRQFGEFGVLLTRNGAGHISYHIGGETSRAMDRYLVNLTVPAPGTVFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJ56</accession>
    <name>C7ZJ56_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_85367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698932">
        <property type="protein sequence ID" value="EEU35955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041668.1">
        <property type="nucleotide sequence ID" value="XM_003041622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJ56"/>
    <dbReference type="GeneID" id="9674073"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85367"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85367"/>
    <dbReference type="eggNOG" id="ENOG502RWZE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1038615_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZJ56"/>
    <dbReference type="OrthoDB" id="5095531at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU35955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="268" mass="29619" checksum="4D8823EEC5319B60" modified="2009-10-13" version="1">MAWMTDASKAGSAGQYELRVWRSWTIGETAPAIVRRCHQPLRVFNVAVRCSRLAEHEPDTIVKANRLLLLRSQTLAPGKAPPSAVVGFSGITAQPVTARAPGNENTEHLDAGDNANGIYFKTEPGSKLCGGNVIWHESMTVPGNIAAIKGQVVHNDRNFPNDTDPIQTLRQEHAKLAEGFPFTPLSFTTPTDQDSSRQPALAKLYTGDFSESIDSHFRLKIPFLGILVILKKFSTRVNTFLWAFPYDPMPQNLAIQAVLVYEHLKDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJ58</accession>
    <name>C7ZJ58_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA2/NAM7 helicase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_49767</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698932">
        <property type="protein sequence ID" value="EEU35957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041670.1">
        <property type="nucleotide sequence ID" value="XM_003041624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJ58"/>
    <dbReference type="STRING" id="660122.C7ZJ58"/>
    <dbReference type="GeneID" id="9674009"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_49767"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_49767"/>
    <dbReference type="eggNOG" id="KOG1802">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099122_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZJ58"/>
    <dbReference type="OMA" id="HREVYND"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="5">
        <location>
            <begin position="53"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU35957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="245" mass="27103" checksum="598626FEC86D76F3" modified="2009-10-13" version="1">MAKGLFDLSKRFVYPDVNCNYGPGCRIELEAHRIGRDLEAFVFVRHPELDAAPTGSLQPIFIHCENSHCHIDPITKSKSNRDQVIVALDFILEFISSTSGRVDASQIAIITPYTANVDVIKSVRRGPKYAALASMKPAKTIYSFQGQESDIIIAIMATTKQAGPGMTTDEHHLNVMLSRHRSGLIIVGDINVTGRLDDERSKRHGHVGLDKFQVVGANGEVSWVNGTMLRSVHQALWESKRVITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKZ1</accession>
    <name>C7ZKZ1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ABC transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_36975</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698942">
        <property type="protein sequence ID" value="EEU35319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041032.1">
        <property type="nucleotide sequence ID" value="XM_003040986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKZ1"/>
    <dbReference type="GeneID" id="9675426"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_36975"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_36975"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_17_8_1"/>
    <dbReference type="InParanoid" id="C7ZKZ1"/>
    <dbReference type="OMA" id="YEMCLGQ"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000057">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000251">
        <property type="entry name" value="ABC transporter B family member 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF11">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="664"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="709"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="780"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="809"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="892"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="926"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="70"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="394"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="669"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="994"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU35319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1239" mass="136050" checksum="40AC976947CAF708" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZL13</accession>
    <name>C7ZL13_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_78288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698942">
        <property type="protein sequence ID" value="EEU35296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041009.1">
        <property type="nucleotide sequence ID" value="XM_003040963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZL13"/>
    <dbReference type="GeneID" id="9675518"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78288"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78288"/>
    <dbReference type="eggNOG" id="ENOG502SVSU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040823_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZL13"/>
    <dbReference type="OMA" id="VEADNWE"/>
    <dbReference type="OrthoDB" id="25129at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU35296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="45769" checksum="2EC0335BA295994C" modified="2009-10-13" version="1">MEADYGKYLSSLYAGTSWSVTRLSGGLVNTTLRATQTSPVQPDAPTSVILKHAKPYVEVAGPEWAFSTKRQEVEAIFLDLFSEHGALSYLRREPFWNSPRCLHHREGKESDLGLSSSDQEASVLILSDLGNLVNIFDFLRQQSNQSWDDIHPKIEKLGYDLGRIFAAIHSPERVIRVQTSNPLAAAKLTHSLTRDIVRTAAIEPLRTRLASTPNADKLFARVKEGFRAQEGAHPWSLAMGDFTQGSVLMRDPSEAEQDWTPTLVDWEFGQLNGRGVDGDLAQFLAHLHCELLSHPQTSALHRAVSALSLRFCAGYASRAGLRLTRRVDDETLRLMRWTFITHGREMVNQACESYKGNERFDEIFKVGVWYLERAGDNVEEFLEEDNWKELEKEDGMMLQSLFEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZL40</accession>
    <name>C7ZL40_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_54591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698943">
        <property type="protein sequence ID" value="EEU35248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040961.1">
        <property type="nucleotide sequence ID" value="XM_003040915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZL40"/>
    <dbReference type="GeneID" id="9675356"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_54591"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_54591"/>
    <dbReference type="eggNOG" id="ENOG502S5BH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030508_0_2_1"/>
    <dbReference type="InParanoid" id="C7ZL40"/>
    <dbReference type="OMA" id="TCCNRIC"/>
    <dbReference type="OrthoDB" id="276515at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09083">
        <property type="entry name" value="EEP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF36">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002989379" description="Endonuclease/exonuclease/phosphatase domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="28"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU35248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="303" mass="34612" checksum="4F87AB3B8845F6F0" modified="2009-10-13" version="1">MKLLWLLVGAVASVAAVPYQRTTNLRLMTYNIRYQVEPSRAEDGEELWPLRRPHMAAQLNYELAGRPDSLVCMQEVTYPQALDLMDDFGEDWALIGGGRRDGAKKGELSPIFYRRSIWNLEQTKTYWLSRTPDKAGSKGWDAELPRVVTVGRFRHLHTGARVVYMCTHFDWKGKKSQGHSAAMIIDLADRWSSHKRESLPVFVAGDLNATPDSPAYNLLATQLYDLKYQVPSSKRFGHQKTYTGFSVDESDDMDLDHMFVRDPMDISFKSFAVLNTRYDDGIFISDHRPVVVDMEITQIARKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLR6</accession>
    <name>C7ZLR6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ran-interacting Mog1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_37417</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MOG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698947">
        <property type="protein sequence ID" value="EEU35035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040748.1">
        <property type="nucleotide sequence ID" value="XM_003040702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLR6"/>
    <dbReference type="FunCoup" id="C7ZLR6">
        <property type="interactions" value="254"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZLR6"/>
    <dbReference type="GeneID" id="9679136"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_37417"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_37417"/>
    <dbReference type="eggNOG" id="KOG3329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081345_1_2_1"/>
    <dbReference type="InParanoid" id="C7ZLR6"/>
    <dbReference type="OMA" id="IDTVKVW"/>
    <dbReference type="OrthoDB" id="10255285at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.10">
        <property type="entry name" value="Mog1/PsbP, alpha/beta/alpha sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007681">
        <property type="entry name" value="Mog1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016123">
        <property type="entry name" value="Mog1/PsbP_a/b/a-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837:SF0">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04603">
        <property type="entry name" value="Mog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55724">
        <property type="entry name" value="Mog1p/PsbP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU35035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="21866" checksum="57F1D57FED8A0542" modified="2009-10-13" version="1">MPEFVSTPLFGGAIVVDLPSNFADVSKLRQVPDNQEVWIDQDGFTSIIFDITERVGSSGSGPEVDGRAMTTHLEDMVGSDINTVKIWNTAETEFSRLEEGTPAYTLISTQTPHVNQSRDTTSAPDFTAIILTLLRLEKQKTDILITINVPHIKGEYDEDEVDLELGRQGKLIGDAVEYSARIWSTFKIKDWGLFGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMA5</accession>
    <name>C7ZMA5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_55064</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698950">
        <property type="protein sequence ID" value="EEU34857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040570.1">
        <property type="nucleotide sequence ID" value="XM_003040524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMA5"/>
    <dbReference type="GeneID" id="9678993"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55064"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55064"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1305150_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZMA5"/>
    <dbReference type="OMA" id="PNITEVY"/>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF13">
        <property type="entry name" value="RESPIRATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="136"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU34857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="211" mass="23622" checksum="AB1E95F5C2AED42C" modified="2009-10-13" version="1">MSTFLDKYTPTSDILGLFADPFERPRQSCASLGPNDPAEPSIAECYSRAHSPPLDRDKLSVRDHNASRTEGRLEFPDMTGFTAEELDREDYAYVEAFDLARFQPVVDLAEKINASAFFPQWAQLNLPPGEVLHVFIQLYFENFHPMFPLIHLPTCSSPETHSLLLFAMAAIGAKYSKLKGAHKCSLAMHELVRQQTQYLVGSRTPVSITSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNP3</accession>
    <name>C7ZNP3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_72158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039738.1">
        <property type="nucleotide sequence ID" value="XM_003039692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNP3"/>
    <dbReference type="GeneID" id="9677578"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_72158"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_72158"/>
    <dbReference type="eggNOG" id="KOG4300">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_6_0_1"/>
    <dbReference type="InParanoid" id="C7ZNP3"/>
    <dbReference type="OMA" id="VWEHGAS"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052356">
        <property type="entry name" value="Thiol_S-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036:SF1">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU34025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="29599" checksum="36A7A53CC34604D8" modified="2009-10-13" version="1">MIGSILRPWGIMSISTFYLFVTVTKLAVSGDLRTLFSWEAFHDAWFGNFWVYMGPKSKAGAEGWVVPLLEGRVKDGKIHEEAQGPPIDGVILEIGAGSGMWTQVLADKSSSKIYGVEPNPISAAALTRRVDETGLVGTYEVLPFGIQDLKDETSIGPGSVDCIITVQCLCSIPEPEKNIRLLYNYLKPGGRWYVYEHVKSEQGTVIPLIQRLTNIPWEYLVGSCKLCRPTLRSILKVGDWDRFNVAPLSGESWLEVIPHIAGTLTKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZP14</accession>
    <name>C7ZP14_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavodoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_101787</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)H dehydrogenase (quinone) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039758.1">
        <property type="nucleotide sequence ID" value="XM_003039712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZP14"/>
    <dbReference type="STRING" id="660122.C7ZP14"/>
    <dbReference type="GeneID" id="9677879"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101787"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101787"/>
    <dbReference type="eggNOG" id="ENOG502QWY5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058643_2_1_1"/>
    <dbReference type="InParanoid" id="C7ZP14"/>
    <dbReference type="OMA" id="HGILHYP"/>
    <dbReference type="OrthoDB" id="26889at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051545">
        <property type="entry name" value="NAD(P)H_dehydrogenase_qn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10204">
        <property type="entry name" value="NAD P H OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10204:SF34">
        <property type="entry name" value="NAD(P)H DEHYDROGENASE [QUINONE] 1 ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like fold" evidence="3">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU34045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="261" mass="29332" checksum="EE9776C85FD54BA5" modified="2009-10-13" version="1">MKVFIVFAHPEPQSLTGSLLKVAVEELEAQGHEVKVSDLYAMKWKAQVDREDFPQQPADERLRVTKASAVATYGGTLTDDVKQEQEKLKWADFIIFQYPLWWYSMPAILKGWVERVLSLGFGYGVGEHSDKHWGDRYGEGVLLGKRGMVVLTVGGMKEHYSARGIGGPLEDLLYPVTHGTLYYTGVEVLPSFAMYKTDRASDEQFQEAAEELRQRMRTLSTAKPIAYRRQNGGDYEIPALTLKPGLEDPGTSGFSLHSRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPB8</accession>
    <name>C7ZPB8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD synthase</fullName>
            <ecNumber evidence="2">2.7.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">FAD pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_49845</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>FMN + ATP + H(+) = FAD + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.2" evidence="2"/>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040037.1">
        <property type="nucleotide sequence ID" value="XM_003039991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZPB8"/>
    <dbReference type="FunCoup" id="C7ZPB8">
        <property type="interactions" value="187"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZPB8"/>
    <dbReference type="GeneID" id="9677556"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_49845"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_49845"/>
    <dbReference type="eggNOG" id="KOG2644">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056971_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZPB8"/>
    <dbReference type="OMA" id="LPYCCLY"/>
    <dbReference type="OrthoDB" id="270728at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23948">
        <property type="entry name" value="FAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293:SF9">
        <property type="entry name" value="FAD SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293">
        <property type="entry name" value="FAD SYNTHETASE-RELATED FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="13">
        <location>
            <begin position="60"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU34324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="198" mass="22337" checksum="12B0949AE2D11A7C" modified="2009-10-13" version="1">MTQAPPPRSLRDKCIEIKDKVDAFLAEVPDTQILRDVQAQLRVSIGVVDEALEKYRPEQISLSYNGGKDCLVLLIVILACMGKRYSQTTATNGTSNSATPEKLQAVYIVASYPFPEIDEFVESSSAEYNLEVARYVLSMKKGLEIYLEERPSIKAIFVGTRRTDPHGENLTHFDPTDSGWPAFMRVHPVIDWHYGTWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQW9</accession>
    <name>C7ZQW9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Xaa-Pro dipeptidyl-peptidase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_55197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699018">
        <property type="protein sequence ID" value="EEU33581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039294.1">
        <property type="nucleotide sequence ID" value="XM_003039248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQW9"/>
    <dbReference type="STRING" id="660122.C7ZQW9"/>
    <dbReference type="GeneID" id="9666822"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55197"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55197"/>
    <dbReference type="eggNOG" id="ENOG502QTIK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015590_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZQW9"/>
    <dbReference type="OMA" id="INHASVC"/>
    <dbReference type="OrthoDB" id="2578740at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00976">
        <property type="entry name" value="CocE_NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF10">
        <property type="entry name" value="COCE_NOND FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase-like" evidence="1">
        <location>
            <begin position="104"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU33581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="252" mass="27526" checksum="8943F5519CAA36D9" modified="2009-10-13" version="1">MRRLLPTDVPRARCTELKQQSVILKKGTTRREVTKPFSSGILFARDVPVTLPDGIPIYTDVFSTRGGPMSSNGGSLESIPEVGGQSLDDLTSRSNVPLSHVSELQKFEAPDLAYWVCQGYAVLNPDARGAYEFNGNITNWGRQLAEDGCDIIEWATAKPWSSGRTGMTGNLFLAISQWHVTASNPPCLAAIAPWEGATDILRAAATSLSIGNLGFKEAIITTLLGNNSVEDSPRMYLNGKFYDKYQKNRTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZR55</accession>
    <name>C7ZR55_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_89423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699034">
        <property type="protein sequence ID" value="EEU33502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039215.1">
        <property type="nucleotide sequence ID" value="XM_003039169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZR55"/>
    <dbReference type="GeneID" id="9666737"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89423"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89423"/>
    <dbReference type="eggNOG" id="ENOG502S9D9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068301_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZR55"/>
    <dbReference type="OMA" id="RCEEGEN"/>
    <dbReference type="OrthoDB" id="5095609at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU33502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="349" mass="38077" checksum="86C1835DB7292A28" modified="2009-10-13" version="1">MEDGSAIASAKGAPQGTLEAAKEVLKGSPFSLNLAKSKEKAIEDLKLEGLKALGTYISPIRPKRTFLQEKLATLQEALEALQDLPKQHSLLLLRGSIQLLLRHLQRQLDPTGLEDLWEEADTLIREAIIALVARSPSESPKEPNSSLIALPVREGGLGIPLHKDLAHELFLAAREASQPTLGLIRKPLAQPTLDQSQPNQGQPRLGKTAQQVLKEANKARLAGFLEDLPASYRHARLENASYLGPISKDSAKEDPYSTLREATEEKRRKYRSLGAFFQPLIISAGGLMDLETAKTYQKLQDLIGPLAANQLDSSISLALMRTRATSAASIARDTPSNLARSIWNTPRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZRD7</accession>
    <name>C7ZRD7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Beta-xylosidase C-terminal Concanavalin A-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_89525</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG699064">
        <property type="protein sequence ID" value="EEU33418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039131.1">
        <property type="nucleotide sequence ID" value="XM_003039085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZRD7"/>
    <dbReference type="GeneID" id="9666654"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89525"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89525"/>
    <dbReference type="eggNOG" id="ENOG502SIVT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016508_3_0_1"/>
    <dbReference type="InParanoid" id="C7ZRD7"/>
    <dbReference type="OMA" id="FYLITAW"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18833">
        <property type="entry name" value="GH43_PcXyl-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF17">
        <property type="entry name" value="BETA-XYLOSIDASE C-TERMINAL CONCANAVALIN A-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002989498" description="Beta-xylosidase C-terminal Concanavalin A-like domain-containing protein" evidence="7">
        <location>
            <begin position="17"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="8">
        <location>
            <begin position="345"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU33418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="588" mass="64504" checksum="2B1D30E27667D8CD" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZRF0</accession>
    <name>C7ZRF0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_56692</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699071">
        <property type="protein sequence ID" value="EEU33409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039122.1">
        <property type="nucleotide sequence ID" value="XM_003039076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZRF0"/>
    <dbReference type="STRING" id="660122.C7ZRF0"/>
    <dbReference type="GeneID" id="9666643"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_56692"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_56692"/>
    <dbReference type="eggNOG" id="ENOG502RJRW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082154_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZRF0"/>
    <dbReference type="OMA" id="IGCQRSE"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="40"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU33409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="200" mass="22639" checksum="FB333C088739BC1D" modified="2009-10-13" version="1">MPSTDLTTPATHSLGQNGPPKRSPAGLDLLPIRRVSDSYLQSFWGIVHPVFPVLHKPTFTQFYQLFWEPADIERVDSTVDDPVMLAKLNLVLAIGCRFTESVDLDSRAIQADEFYQRARRLVPIDSLDAASLPIIQMLLLTAIHLQSTTYSSRCWNMVGLATRVAQSLGLHLNRGESETGNQLEREMRRRVWYTCVTLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7YGR8</accession>
    <name>C7YGR8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_74717</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053501.1">
        <property type="nucleotide sequence ID" value="XM_003053455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YGR8"/>
    <dbReference type="FunCoup" id="C7YGR8">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YGR8"/>
    <dbReference type="GeneID" id="9664302"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74717"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74717"/>
    <dbReference type="eggNOG" id="KOG0752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_10_3_1"/>
    <dbReference type="InParanoid" id="C7YGR8"/>
    <dbReference type="OMA" id="MYVCYGA"/>
    <dbReference type="OrthoDB" id="18574at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090422">
        <property type="term" value="F:thiamine pyrophosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000011">
        <property type="entry name" value="Mitochondrial thiamine pyrophosphate carrier 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF10">
        <property type="entry name" value="SLC (SOLUTE CARRIER) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="107"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="200"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU47788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="311" mass="34223" checksum="48BE208C6F81866A" modified="2009-10-13" version="1">MRLQTVSAGAIAGLVSRFVVAPLDVVKIRLQLQPFSLSDPLAPLREAPAYRGAFATLQHILKHEGITGLWKGNVPAELLYVCYGAVQFTTYRSTTVFLQTAFPTRLPDAAESFIAGAASGAAATGVTYPLDLLRTRFAAQGRHRIYRSLRSAIWDIQRDEGWRGFFRGIGPGLGQIVPFMGLFFVSYESLRTSLEGLHMPWGSGDATAGMMASILAKTAVFPLDLVRKRIQVQGPSRNRYVYENIPEYSTARGAIRSILRTEGFRGLYKGLPISLIKAAPASAVTLWTYEQTMQFMLGWNSGAEAVIREEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7YH66</accession>
    <name>C7YH66_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_74864</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054291.1">
        <property type="nucleotide sequence ID" value="XM_003054245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YH66"/>
    <dbReference type="FunCoup" id="C7YH66">
        <property type="interactions" value="549"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YH66"/>
    <dbReference type="GeneID" id="9674452"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74864"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74864"/>
    <dbReference type="eggNOG" id="KOG3998">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056195_0_0_1"/>
    <dbReference type="InParanoid" id="C7YH66"/>
    <dbReference type="OMA" id="RHRHFPW"/>
    <dbReference type="OrthoDB" id="7859621at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002995">
        <property type="entry name" value="Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF1">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02077">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01339">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU48578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="302" mass="33811" checksum="CFD574581EAD6EB6" modified="2009-10-13" version="1">MSQRFNSGYGLGGPAPYGAAQSVDTQQSEGALEQIRLYTSKIEDALDNLSEPVKPYLPAIGRFLIVVTFFEDALRIITQWSDQLLYLRDYRHIPSGITHLFLLANILAMFSCSILVIIRKHSDYAVAGLMGVVVTQALGYGLIFDLNFFLRNLSVIGGLVMVLSDSWVRKTKAFAGLPQIDEKDRKMYFQLAGRVLLIFLFVGFVFSGQWSLWRVLVSILGGVACVMVVVGFKAKYSATLLVVILSIFNLLVNNFWTLHEHHPHKDFAKYDFFQILSIVGGLLLLVNSGPGQFSIDEKKKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7YH77</accession>
    <name>C7YH77_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_74875</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054297.1">
        <property type="nucleotide sequence ID" value="XM_003054251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YH77"/>
    <dbReference type="STRING" id="660122.C7YH77"/>
    <dbReference type="GeneID" id="9664453"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74875"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74875"/>
    <dbReference type="eggNOG" id="ENOG502RY0W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026939_1_0_1"/>
    <dbReference type="InParanoid" id="C7YH77"/>
    <dbReference type="OMA" id="LGPKFMW"/>
    <dbReference type="OrthoDB" id="26203at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053247">
        <property type="entry name" value="GPCR_GPR1/git3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42058:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42058">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="56"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU48584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="492" mass="54441" checksum="044BC56004F35942" modified="2009-10-13" version="1">MTNTSVGLNLCPPPFFDQTLFPDEGGFVDGRLCQTVGTMQCCLPCPMTDWVYPDRFETLTAVANWVAAFSVLCCVFLLLSWAFLPVDKTNRHYLSICLTFAVLLMNLGFVIPLAARPDQCYNEITPHSMKTSQVCGASGAFLLLGGWAGVMWVFLRSVSLHLQICWQVLVGRNFMIFAQAAGWGVPILGIILALVFSGVSFRFGATCHINHANSLADFWIPLLLFAGLTVIITFATFGYCIKVYLTALGDNGASSEGSSLPTYTQSIKTMSPRQAYRRVRRVIALQWRGIAIVLIIIADVIFFSVIFVFQDNVVQSVTDDPTLAEDWVKCLVLENGKKANCLDEATALVLNEATITAVLLLLALNGLWLLFFLGRWSMAQGWLELFSKPFKNKNKKEFVSVDAHIDAKNSTRSYEMLSRDSSAAVTPITPVKSPESGRRTPDYFGRTARYHAPARSFSSPRPPPAASWDAGETFALPTYKDKDMHPLSMNQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHB5</accession>
    <name>C7YHB5_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_74913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054315.1">
        <property type="nucleotide sequence ID" value="XM_003054269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YHB5"/>
    <dbReference type="GeneID" id="9674477"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74913"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74913"/>
    <dbReference type="eggNOG" id="ENOG502S8YJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1305149_0_0_1"/>
    <dbReference type="InParanoid" id="C7YHB5"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846:SF1">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU48602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="211" mass="23461" checksum="076D14511540FFF2" modified="2009-10-13" version="1">MPTVTPLLALYLGSFLLTLLLTSLLNLDPRTHPLLRTHPLLKTHLHPAWKMYQLRRFATAMLRLAKMDATGEGAKGSAGLTVTATAPPDPKDKAGRRDQQNGDGQKNGLNDFQRLCVDLGLSGKLGSKNKCRKVCQPQTRQKGTGIDLCQEIKNVNVNIGQFLKSKNKPGDVKFFEDKRALVKYTKETNSFYPKKQLPKGDSLRALLKQSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHQ9</accession>
    <name>C7YHQ9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_103177</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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            <begin position="559"/>
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    <sequence length="658" mass="74469" checksum="76124E158EB8D90F" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7YI50</accession>
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            <fullName evidence="18">Meiotically up-regulated gene 190 protein</fullName>
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        <name evidence="16" type="ORF">NECHADRAFT_98912</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
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            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
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            <strain evidence="17">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
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            <dbReference type="EMBL" id="EEU48744.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
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    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1214" mass="136362" checksum="76FB30F73D54E1E5" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIG2</accession>
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        <recommendedName>
            <fullName evidence="8">MYND-type domain-containing protein</fullName>
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        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beclin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054511.1">
        <property type="nucleotide sequence ID" value="XM_003054465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIG2"/>
    <dbReference type="FunCoup" id="C7YIG2">
        <property type="interactions" value="539"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YIG2"/>
    <dbReference type="GeneID" id="9664562"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_30705"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_30705"/>
    <dbReference type="eggNOG" id="KOG2751">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_356810_0_0_1"/>
    <dbReference type="InParanoid" id="C7YIG2"/>
    <dbReference type="OMA" id="EWDVYKA"/>
    <dbReference type="OrthoDB" id="20368at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.40:FF:000005">
        <property type="entry name" value="Autophagy protein Apg6, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.40">
        <property type="entry name" value="Autophagy protein 6/Beclin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007243">
        <property type="entry name" value="Atg6/Beclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038274">
        <property type="entry name" value="Atg6/Beclin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041691">
        <property type="entry name" value="Atg6/beclin_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040455">
        <property type="entry name" value="Atg6_BARA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768">
        <property type="entry name" value="BECLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768:SF4">
        <property type="entry name" value="BECLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04111">
        <property type="entry name" value="APG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17675">
        <property type="entry name" value="APG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="8">
        <location>
            <begin position="484"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="28"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="153"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU48798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="786" mass="88531" checksum="6D4A0E619206A454" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIJ7</accession>
    <name>C7YIJ7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7721 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_75348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054532.1">
        <property type="nucleotide sequence ID" value="XM_003054486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIJ7"/>
    <dbReference type="GeneID" id="9664651"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75348"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75348"/>
    <dbReference type="eggNOG" id="ENOG502S2II">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063290_2_2_1"/>
    <dbReference type="InParanoid" id="C7YIJ7"/>
    <dbReference type="OMA" id="KFTQGET"/>
    <dbReference type="OrthoDB" id="2290255at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056138">
        <property type="entry name" value="DUF7721"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477:SF1">
        <property type="entry name" value="BETA-FLANKING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24845">
        <property type="entry name" value="DUF7721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7721" evidence="2">
        <location>
            <begin position="74"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU48819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="229" mass="24818" checksum="1EAF771AA11A6E03" modified="2009-10-13" version="1">MDKLVSAAKDFLDDDKDKRQEQSQQQQYGGGQQYGQQQQYGQEQYGQQQQYPPPGGVQSHGGGSGISSFFGNLDFDHAKEEANKNAGSSGDKDLFSNILGSLGQKQNKLANEDLDEEDAIKKHKKTYEDSEDEEDDKSMGTAAAMQALKLFNKGETKSSSSSQSAFLGLAMAEASKLFDDKAAKGKVTSDASKESVVQQAGEVALKMYLKNQGEQQGGLLGMASKFMNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJ69</accession>
    <name>C7YJ69_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">fumarate reductase (NADH)</fullName>
            <ecNumber evidence="7">1.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NADH-dependent fumarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_65946</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="7"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053929.1">
        <property type="nucleotide sequence ID" value="XM_003053883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJ69"/>
    <dbReference type="FunCoup" id="C7YJ69">
        <property type="interactions" value="64"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YJ69"/>
    <dbReference type="GeneID" id="9676565"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_65946"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_65946"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011398_4_5_1"/>
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        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
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    </dbReference>
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        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
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    </dbReference>
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        <property type="entry name" value="CYTOCHROME_B5_2"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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            <end position="622"/>
        </location>
    </feature>
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            <end position="543"/>
        </location>
    </feature>
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            <end position="543"/>
        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00050832"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00067004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEU48216.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="630" mass="67912" checksum="F3027191D112B051" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJ82</accession>
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        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_75588</name>
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    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75588"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_446236_0_0_1"/>
    <dbReference type="InParanoid" id="C7YJ82"/>
    <dbReference type="OrthoDB" id="4772970at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="132"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="612"/>
        </location>
    </feature>
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        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
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        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU48934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="612" mass="67298" checksum="03B5C6E5799305E2" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJX8</accession>
    <name>C7YJX8_FUSV7</name>
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        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_31015</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
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                <person name="Selker E.U."/>
                <person name="Salamov A."/>
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                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
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            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
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            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
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    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053355.1">
        <property type="nucleotide sequence ID" value="XM_003053309.1"/>
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    <dbReference type="FunCoup" id="C7YJX8">
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    </dbReference>
    <dbReference type="STRING" id="660122.C7YJX8"/>
    <dbReference type="GeneID" id="9676686"/>
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    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_31015"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_5_11_1"/>
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    <dbReference type="OMA" id="APVHDFV"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="probable ATP-dependent RNA helicase DHX40"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
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        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF118">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="120"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="336"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU47642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="779" mass="86349" checksum="AD1D46EF776BA6AB" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7YKI2</accession>
    <name>C7YKI2_FUSV7</name>
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        <recommendedName>
            <fullName evidence="7">Kelch repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_65530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054171.1">
        <property type="nucleotide sequence ID" value="XM_003054125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YKI2"/>
    <dbReference type="GeneID" id="9676786"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_65530"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_65530"/>
    <dbReference type="eggNOG" id="KOG0379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012508_0_0_1"/>
    <dbReference type="InParanoid" id="C7YKI2"/>
    <dbReference type="OMA" id="ATFTQMN"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF3">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="665"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="748"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="775"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU48458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="831" mass="89107" checksum="46762E7E6782A8C0" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7YKL7</accession>
    <name>C7YKL7_FUSV7</name>
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        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_74653</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053474.1">
        <property type="nucleotide sequence ID" value="XM_003053428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YKL7"/>
    <dbReference type="STRING" id="660122.C7YKL7"/>
    <dbReference type="GeneID" id="9664267"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74653"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74653"/>
    <dbReference type="eggNOG" id="KOG0226">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_29_0_1"/>
    <dbReference type="InParanoid" id="C7YKL7"/>
    <dbReference type="OMA" id="FTAFQPR"/>
    <dbReference type="OrthoDB" id="1749473at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF11">
        <property type="entry name" value="RNA-BINDING PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="225"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="305"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU47761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="364" mass="38292" checksum="F242BDB2C2F91F6F" modified="2009-10-13" version="1">MAYPPPPGISNNSLPPRPPASKGGFKPAFSSAAQSSKPAYSSAPPTYSGPSSYPATTAAPAAQYAPSYSSYPTGSAPGAVSSGAPTSYSYPQQPQQQQQSYGPQSYGAQNYGPQSYEPQSYGAASYGAAPQIRNPFPTPGTASNDYDPEMAAQIAQWQSAYVSRDATEGKTDKPAGPSAPRPDIQPAGAANAASAAQEKKKTVVREGGGKKWTDDTLLEWDPSHLRLFVGNLAGETTDDALLKAFSRWRSVQKARVIRDKRTSKSKGYGFVSFSDADDFFQAAKEMNGKYIQSHPVVVRKANTEIKVANAKDKDRNNRKNKNHKKGGHGGGNGGGGYEPSLGPIGGGGVVKPGQKTKNGLRLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLI6</accession>
    <name>C7YLI6_FUSV7</name>
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        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_103675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052983.1">
        <property type="nucleotide sequence ID" value="XM_003052937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YLI6"/>
    <dbReference type="STRING" id="660122.C7YLI6"/>
    <dbReference type="GeneID" id="9663749"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_103675"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_103675"/>
    <dbReference type="eggNOG" id="ENOG502S19D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074138_0_0_1"/>
    <dbReference type="InParanoid" id="C7YLI6"/>
    <dbReference type="OMA" id="TQEMKPR"/>
    <dbReference type="OrthoDB" id="7763451at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343:SF10">
        <property type="entry name" value="RNA-BINDING REGION RNP-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343">
        <property type="entry name" value="SERINE/ARGININE-RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="5"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU47270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="279" mass="30023" checksum="BE9DCC9DA0899211" modified="2009-10-13" version="1">MASNATVHVKNIAVATSDSEIKDFFSFCGKIADLKVTTEGETKSADVTFEKETAKKTALLLHNTQLGPNHLEVTSAGEDVDDDAAHPTKNADRDSDEITQEEKPRARILAEYLAHGYVIGDAAIQRGIELDSKHNVSNRFLTTLQNLDTKYHATDRAKATDQSYGITQRANSLWLGLSSYFEKASHTPTGKKIAQFYTDGSRQVQEVHAEARRLADLKTEEAGGSAYKAAGLEKVFGKEKTSGTTAPESGPGDSTGTSTQPAPTENIPSVSAPEGGEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLU8</accession>
    <name>C7YLU8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_35639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053047.1">
        <property type="nucleotide sequence ID" value="XM_003053001.1"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YLU8"/>
    <dbReference type="GeneID" id="9671083"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_35639"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_35639"/>
    <dbReference type="eggNOG" id="ENOG502QRPA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002643_0_0_1"/>
    <dbReference type="InParanoid" id="C7YLU8"/>
    <dbReference type="OMA" id="DETMTPR"/>
    <dbReference type="OrthoDB" id="5423926at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="857"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="562"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="766"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="857"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="878"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="970"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1201"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1287"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1307"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1369"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1503"/>
            <end position="1519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU47334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1519" mass="165106" checksum="4F6EC968B3259568" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7YM84</accession>
    <name>C7YM84_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_77791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052613.1">
        <property type="nucleotide sequence ID" value="XM_003052567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YM84"/>
    <dbReference type="STRING" id="660122.C7YM84"/>
    <dbReference type="GeneID" id="9671145"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77791"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77791"/>
    <dbReference type="eggNOG" id="ENOG502SJRE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_441481_0_0_1"/>
    <dbReference type="InParanoid" id="C7YM84"/>
    <dbReference type="OMA" id="RYIVAGK"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="21"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU46900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="624" mass="71532" checksum="CD7CF23339ECCA64" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7YM93</accession>
    <name>C7YM93_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_67396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052619.1">
        <property type="nucleotide sequence ID" value="XM_003052573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YM93"/>
    <dbReference type="FunCoup" id="C7YM93">
        <property type="interactions" value="1104"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YM93"/>
    <dbReference type="GeneID" id="9671151"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_67396"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_67396"/>
    <dbReference type="eggNOG" id="KOG0687">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031814_1_0_1"/>
    <dbReference type="InParanoid" id="C7YM93"/>
    <dbReference type="OMA" id="RLHCKVD"/>
    <dbReference type="OrthoDB" id="1452at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005838">
        <property type="term" value="C:proteasome regulatory particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000013">
        <property type="entry name" value="Proteasome regulatory particle subunit (RpnG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000021">
        <property type="entry name" value="Putative proteasome regulatory particle subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049549">
        <property type="entry name" value="RPN7_PSMD6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21154">
        <property type="entry name" value="RPN7_PSMD6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="229"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU46906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="485" mass="53641" checksum="FBC4C9C9591EE56D" modified="2009-10-13" version="1">MGSDPQYAKWPLLPLSQHVFTLTNAYASKTAQQAAVKVLQDAIAEDKMAPFYRYLAHPLDGVLNTIGEGGASAPGRPLSRKSSLVGMVATKPAATVISLPWDEGLYNQLKEDNDRELQEFQKEEDEAVEQAGDTEIMAAKGKRAEFWARVGDKDKAIAAYESVFEKTGILGTKIDLVLAIIRMGLFYGDKPLVKKHVERAKTLVETGGDWDRRNRLKAYEGLHLLTVRSYNLAAPLLLDSLSTFTSYELCTYSNLVVYSVLAGSVSLKRVDFKSKVVDAPEIKAILGDGEDKLLALSGALSAGPGADDTTGVKAPKTAAVNLTTLGTSTDQPEAELAIDFSPLALLVSSLYNGNYKTFFRSLAEVEEQFLNQDRYLHEHKSWFIREMRLRAYQQLLQSYRVVGLESMANDFGVTVDFLDRDLARFIAAGRIPCTIDRVTGKGVIETNRPDDKNKQYQDVVRQGDQLITKLQKYGQAVRLRGSERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7YMJ1</accession>
    <name>C7YMJ1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_35927</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053168.1">
        <property type="nucleotide sequence ID" value="XM_003053122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YMJ1"/>
    <dbReference type="FunCoup" id="C7YMJ1">
        <property type="interactions" value="491"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YMJ1"/>
    <dbReference type="GeneID" id="9671205"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_35927"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_35927"/>
    <dbReference type="eggNOG" id="KOG2906">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093932_3_0_1"/>
    <dbReference type="InParanoid" id="C7YMJ1"/>
    <dbReference type="OMA" id="MEFCDEC"/>
    <dbReference type="OrthoDB" id="282152at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10509">
        <property type="entry name" value="Zn-ribbon_RPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034014">
        <property type="entry name" value="Zn_ribbon_RPC11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF12">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="12">
        <location>
            <begin position="82"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU47455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="126" mass="14415" checksum="372B08B67660AB56" modified="2009-10-13" version="1">MLLCKTHSVPNTNLTNKLAVCPHCANILTVSFTNTRTNRLECRTCPFEHHITEPVFSRRMYERVEKEDVFGGPGAWDNAQKGRVQCPNDGCNGDEAAFFQVQIRSADEPMTSFYKCMTCGHRWREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7YMU1</accession>
    <name>C7YMU1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MYND-type zinc finger protein samB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_35531</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698897">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003052678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YMU1"/>
    <dbReference type="GeneID" id="9664208"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_35531"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_35531"/>
    <dbReference type="eggNOG" id="ENOG502RVVP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_302681_0_0_1"/>
    <dbReference type="InParanoid" id="C7YMU1"/>
    <dbReference type="OMA" id="DIEMHDW"/>
    <dbReference type="OrthoDB" id="5424793at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="508"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="994"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1002"/>
            <end position="1016"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU47011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1042" mass="117796" checksum="D9E8A2DFD09CD06A" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7YN38</accession>
    <name>C7YN38_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SDG2111</name>
        <name evidence="2" type="ORF">NECHADRAFT_105995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053266.1">
        <property type="nucleotide sequence ID" value="XM_003053220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YN38"/>
    <dbReference type="STRING" id="660122.C7YN38"/>
    <dbReference type="GeneID" id="9671304"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_105995"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_105995"/>
    <dbReference type="eggNOG" id="KOG1337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041939_3_2_1"/>
    <dbReference type="InParanoid" id="C7YN38"/>
    <dbReference type="OMA" id="ISHMKDE"/>
    <dbReference type="OrthoDB" id="441812at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF137">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="19"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU47553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="371" mass="42105" checksum="875F2B43D9E21C22" modified="2009-10-13" version="1">MSIDEAFLPWAEGKGVKLKGIEPRILPGRGIGVVATRDIRENEAILTVPMKALRTIDTVPKQISKALHGVSVHGILAAEIALDKSDDFAVWKTVLPTKEDLESGMPMMWPSELQLLLPRRAKNLLDKQTTTFRRECEIVLNAFPNLTRDDYLYAWVLINTRTFYNSMPKMKAYAQADRLVCMPAADLFNHADQGCQLSFSPLGYTIKADRVYRQGEEVYVSYGPHSNDFLLTEYGFILGPNRWDEVYLDDVILPLLNKTQRAELASVDFLGRFTLDDQTLGCHRTQVALRMLCCTPGQWQRFFDAVDDGHASQDEVNELLLMALKDFLGMIAKTMDEIDETEGGLGNQRELLRQRWQQIQAMVTKTIETLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNJ7</accession>
    <name>C7YNJ7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin carboxyl-terminal hydrolase 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_79331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EEU46136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003051803.1"/>
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    <dbReference type="eggNOG" id="ENOG502RVVW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019318_0_0_1"/>
    <dbReference type="InParanoid" id="C7YNJ7"/>
    <dbReference type="OMA" id="REDIWRV"/>
    <dbReference type="OrthoDB" id="5369841at2759"/>
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        <location>
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            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEU46136.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="617" mass="66951" checksum="E6867E74A0FD93C1" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPG0</accession>
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            <fullName evidence="4">Genetic interactor of prohibitins 3, mitochondrial</fullName>
        </recommendedName>
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        <name evidence="2" type="ORF">NECHADRAFT_37842</name>
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        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
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                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
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                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
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            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EEU46292.1"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
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        <property type="entry name" value="Mito_lipid_metab_GTPase"/>
    </dbReference>
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    </dbReference>
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    </feature>
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        <location>
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        <location>
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        <location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEU46292.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="733" mass="81280" checksum="3565006F3885295A" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQ50</accession>
    <name>C7YQ50_FUSV7</name>
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            <fullName evidence="17 18">Pyruvate carboxylase</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="27" type="ORF">NECHADRAFT_100039</name>
    </gene>
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        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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            <taxon>Fusarium</taxon>
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            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
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                <person name="Kroken S."/>
                <person name="Molnar I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="28">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="function">
        <text evidence="3">Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>hydrogencarbonate + pyruvate + ATP = oxaloacetate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 18">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
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    <dbReference type="GeneID" id="9668904"/>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.600.10">
        <property type="entry name" value="pyruvate carboxylase f1077a mutant domain"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="PCB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005930">
        <property type="entry name" value="Pyruv_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006761">
        <property type="entry name" value="PRK09282.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009554">
        <property type="entry name" value="PRK12999.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01235">
        <property type="entry name" value="pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778">
        <property type="entry name" value="PYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778:SF2">
        <property type="entry name" value="PYRUVATE CARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
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    </dbReference>
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        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="11 18 20" id="KW-0547">Nucleotide-binding</keyword>
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        <location>
            <begin position="16"/>
            <end position="463"/>
        </location>
    </feature>
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        <location>
            <begin position="133"/>
            <end position="330"/>
        </location>
    </feature>
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        <location>
            <begin position="549"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="23">
        <location>
            <begin position="1087"/>
            <end position="1162"/>
        </location>
    </feature>
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        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="558"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="630"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="21">
        <location>
            <position position="726"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="756"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="758"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="891"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="22">
        <location>
            <position position="726"/>
        </location>
    </feature>
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        <location>
            <position position="1128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00002380"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013057"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
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            <dbReference type="ARBA" id="ARBA00072910"/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEU46408.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1164" mass="127698" checksum="4951D78DE6612817" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQ88</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">NECHADRAFT_79019</name>
    </gene>
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        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreomycetidae</taxon>
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        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU45979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="205" mass="23085" checksum="8355B4555518F10D" modified="2009-10-13" version="1">MDPEVKIEQEALTADFPLFPGFYDHDQDAEGQEEFATVADSLSLKGQVWPGMGKMDLANDEMRRTRNQRKPKSVIDKMKRASEGIVPNQVIMTPDFKVERVKDVYDDSSSPIPGQEESTPPRKVPKPRRKKATPLAEVSANVPKQRRNTARGLKSNTGKRAEVKPTIDGQDDSGIATSPFHFRHGHDVFRDDDEHLEGLIYVIDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQ99</accession>
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        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit M</fullName>
            <shortName evidence="5">eIF3m</shortName>
        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">NECHADRAFT_68360</name>
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    <organism evidence="8 9">
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            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit M family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051697.1">
        <property type="nucleotide sequence ID" value="XM_003051651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQ99"/>
    <dbReference type="STRING" id="660122.C7YQ99"/>
    <dbReference type="GeneID" id="9668926"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_68360"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_68360"/>
    <dbReference type="eggNOG" id="KOG2753">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035254_0_0_1"/>
    <dbReference type="InParanoid" id="C7YQ99"/>
    <dbReference type="OMA" id="FNDEHKG"/>
    <dbReference type="OrthoDB" id="10267031at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03012">
        <property type="entry name" value="eIF3m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027528">
        <property type="entry name" value="eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040750">
        <property type="entry name" value="eIF3m_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF2">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18005">
        <property type="entry name" value="eIF3m_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="187"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="398"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU45984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="449" mass="50938" checksum="76B5693DA498315A" modified="2009-10-13" version="1">MAAPKTAGQPTLVFVDGAFEDLAAEMADYLKAEDAKQLLSNEKAPSTEDVVAKLVSASAALNTVPEKEYTAASNLMIHLVLQSAEPKKHLPTLCTTFAKPLINSPVHGVGLSLNALTTVFNLLDPNDPVRARVFMEILKFLRSHGMYDGLRTYLDKLPEWLAAWGTDVDFQRKIYEEVAEVALEAGEETQGYEYILKALRTFEGDEKDDVSSEDAQRLSLRAVKMALLSSTHFLFQDLRGIPSVQALSDSHPVYSQLLDIFAEQDLEDYNDFNEEHEGWVEKEKLSHERLHRKMRLLTFASLAAATPSREIEYSKITRALQIPSEEIEMWAIDVIRAGLVEGKLSQQRQHFLVHKVTYRVFGQKQYQELATRVDHWRSTLQNVLSVLRQEQANAKAQKEREIQDLERKVANAGLGGNQEGGNRRRQGQQREQREPREQQPPRERTENDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRJ7</accession>
    <name>C7YRJ7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWR1-complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SWRCA2101</name>
        <name evidence="11" type="ORF">NECHADRAFT_93602</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SWC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051185.1">
        <property type="nucleotide sequence ID" value="XM_003051139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YRJ7"/>
    <dbReference type="FunCoup" id="C7YRJ7">
        <property type="interactions" value="935"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YRJ7"/>
    <dbReference type="GeneID" id="9665893"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_93602"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_93602"/>
    <dbReference type="eggNOG" id="KOG2656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018539_3_1_1"/>
    <dbReference type="InParanoid" id="C7YRJ7"/>
    <dbReference type="OMA" id="GNTTMYQ"/>
    <dbReference type="OrthoDB" id="19740at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032563">
        <property type="entry name" value="DAMP1_SANT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027109">
        <property type="entry name" value="Swc4/Dmap1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855:SF10">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16282">
        <property type="entry name" value="SANT_DAMP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="144"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="61"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="329"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="500"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="516"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="533"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU45472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="565" mass="62993" checksum="879F82940CB3DDBF" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRK5</accession>
    <name>C7YRK5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_40581</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051188.1">
        <property type="nucleotide sequence ID" value="XM_003051142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YRK5"/>
    <dbReference type="STRING" id="660122.C7YRK5"/>
    <dbReference type="GeneID" id="9665898"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_40581"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_40581"/>
    <dbReference type="eggNOG" id="ENOG502QT5J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004835_0_1_1"/>
    <dbReference type="InParanoid" id="C7YRK5"/>
    <dbReference type="OMA" id="RDKGTEC"/>
    <dbReference type="OrthoDB" id="5244761at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="261"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="469"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="543"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="625"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1102"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU45475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1126" mass="124291" checksum="F5CC1E198611620D" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRN0</accession>
    <name>C7YRN0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Leukotriene A(4) hydrolase</fullName>
            <shortName evidence="14">LTA-4 hydrolase</shortName>
            <ecNumber evidence="14">3.3.2.10</ecNumber>
            <ecNumber evidence="14">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">NECHADRAFT_104478</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an epoxide + H2O = an ethanediol</text>
            <dbReference type="Rhea" id="RHEA:19037"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32955"/>
            <dbReference type="ChEBI" id="CHEBI:140594"/>
            <dbReference type="EC" id="3.3.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.10" evidence="14"/>
    <dbReference type="EC" id="3.4.11.-" evidence="14"/>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051204.1">
        <property type="nucleotide sequence ID" value="XM_003051158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YRN0"/>
    <dbReference type="FunCoup" id="C7YRN0">
        <property type="interactions" value="1076"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YRN0"/>
    <dbReference type="MEROPS" id="M01.034"/>
    <dbReference type="GeneID" id="9667975"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_104478"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_104478"/>
    <dbReference type="eggNOG" id="KOG1047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014505_1_1_1"/>
    <dbReference type="InParanoid" id="C7YRN0"/>
    <dbReference type="OMA" id="CTALQWM"/>
    <dbReference type="OrthoDB" id="79562at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09599">
        <property type="entry name" value="M1_LTA4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000009">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.320:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000004">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.30:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.320">
        <property type="entry name" value="Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012777">
        <property type="entry name" value="LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049980">
        <property type="entry name" value="LTA4H_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038502">
        <property type="entry name" value="M1_LTA-4_hydro/amino_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034015">
        <property type="entry name" value="M1_LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015211">
        <property type="entry name" value="Peptidase_M1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02411">
        <property type="entry name" value="leuko_A4_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726:SF3">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09127">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01263">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 14" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal" evidence="15">
        <location>
            <begin position="496"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="166"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="296"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="592"/>
            <end position="594"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEU45491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="636" mass="72034" checksum="03C8F1A5C92E49D9" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRP6</accession>
    <name>C7YRP6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_104483</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050822.1">
        <property type="nucleotide sequence ID" value="XM_003050776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YRP6"/>
    <dbReference type="STRING" id="660122.C7YRP6"/>
    <dbReference type="GeneID" id="9665915"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_104483"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_104483"/>
    <dbReference type="eggNOG" id="ENOG502SFKU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055491_3_5_1"/>
    <dbReference type="InParanoid" id="C7YRP6"/>
    <dbReference type="OMA" id="IWTAGKL"/>
    <dbReference type="OrthoDB" id="5320223at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU45109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="137" mass="14949" checksum="84AE0324B4CE99C1" modified="2009-10-13" version="1">MPLAGHCLCKAVTYTVDMDEPLLVGYDHCDDCQRQSGSTYSLVAVVKKDKLTINGPVKTYSGSKGSSGKIVHRLFCSECGSPIAHDPDAAPEIIALKAGTFESELKQKLKPDTEIWTVGKLPFCQEHLAKPFTHMPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRZ0</accession>
    <name>C7YRZ0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_61308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050867.1">
        <property type="nucleotide sequence ID" value="XM_003050821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YRZ0"/>
    <dbReference type="FunCoup" id="C7YRZ0">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="GeneID" id="9666035"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_61308"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_61308"/>
    <dbReference type="eggNOG" id="ENOG502RJPB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024079_4_0_1"/>
    <dbReference type="InParanoid" id="C7YRZ0"/>
    <dbReference type="OMA" id="FWPGDIA"/>
    <dbReference type="OrthoDB" id="188042at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009291">
        <property type="entry name" value="Vps62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48172">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48172:SF2">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING PROTEIN 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06101">
        <property type="entry name" value="Vps62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU45154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="492" mass="57615" checksum="8357ECE9B87ED704" modified="2009-10-13" version="1">MLLISFGAWLAPRVLDPTDKGPEKRLRDRRWVDSSPYFWDRQACRWIGVCGLHHLRSDPAARKNHDEDEPEWGELKRRSLSWEPENIPRQDRKRNLHHRRRILRDIPDYVMKHAPLVHLYSGEEFWPSDIREHVEHMTVQVDDTPLNSTEKWTLHNLHKLNKVTGNVILQSNDDVEDRPNWLHSHHNIPKPFPDEEEGNHDNNPTPPGNPEQNPELREPTTWYDIDKSHPLHRINDPRNRKFQKDRRSEQEPIRTNGHKPDKNGFSNAPAVLIVVDKGSGIVDAFWFFFYSYNLGQTVLNIRFGNHVGDWEHCMVRFEHGKPRGVFFSEHEGGQAYAFEAVEKRGDRPVIYSAVGSHAMYALPGVHAYILPFKLLKDVTDKGPLWDPALNNYAYHYDYTREVDDDDDDPREPQSLIPAASNPHAPTSWFHFGGRWGDEVYSLADPRQWRFFGQYHYVTGPDGPRFKGLDRAKMCQTRKCKILYKLDPKGTWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSS2</accession>
    <name>C7YSS2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_69715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051408.1">
        <property type="nucleotide sequence ID" value="XM_003051362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSS2"/>
    <dbReference type="GeneID" id="9668331"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_69715"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_69715"/>
    <dbReference type="HOGENOM" id="CLU_1959769_0_0_1"/>
    <dbReference type="InParanoid" id="C7YSS2"/>
    <dbReference type="OMA" id="WVLCYVN"/>
    <dbReference type="OrthoDB" id="5091764at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988254" evidence="1">
        <location>
            <begin position="20"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU45695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="144" mass="15929" checksum="6F8653890B991C03" modified="2009-10-13" version="1">MHFTTLIAATAALASTATARFLPPDAMEMLKRTMVPNHVSAKVVAVNGFGKDQTKHTILVPLGRLTHVSRTQITELRVEGVDHVAEAPKPAEDNIVCQRYLNQYASKIGSERFTNKAPAHISTNPVDFGWILCYVTNEQWNSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSV2</accession>
    <name>C7YSV2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_41535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051425.1">
        <property type="nucleotide sequence ID" value="XM_003051379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSV2"/>
    <dbReference type="GeneID" id="9666334"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_41535"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_41535"/>
    <dbReference type="eggNOG" id="ENOG502QWD2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073157_0_0_1"/>
    <dbReference type="InParanoid" id="C7YSV2"/>
    <dbReference type="OMA" id="GADTMCL"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF22">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU45712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="331" mass="36141" checksum="9DDFEDD76A5AB904" modified="2009-10-13" version="1">MSSSSRKVCVTAADGNTGFLIAELILKNRDFSRKVSGVVGLALDPDSDHAKELKELGATIVRHEPGRLRVMIKALKETGCDTICLVPPAHEHKIEICEELARAAKKADIPNVCLISSAGCDYAERDKQPRLREFIDLESLVLEAKGDPSTSTGTSACVIRAGFYAENLLLYAPQAKEEGILPLPIGEKHKFAPVALGDVAHVAAHVLTGKGKHGFDDKHRGQMMVVTGPTLCAGKELAAAASKALGRELQFEHIAQAEAKKVLKAQSDIDQSEQQYILEYYSLVREGKTNYVATTAFHDVTGEHPTDAENFFQMYQSEMRPKKKAKHEHKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSW5</accession>
    <name>C7YSW5_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_122604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051433.1">
        <property type="nucleotide sequence ID" value="XM_003051387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSW5"/>
    <dbReference type="GeneID" id="9666339"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_122604"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_122604"/>
    <dbReference type="HOGENOM" id="CLU_1928160_0_0_1"/>
    <dbReference type="InParanoid" id="C7YSW5"/>
    <dbReference type="OrthoDB" id="5004027at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988256" evidence="1">
        <location>
            <begin position="19"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU45720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="122" mass="13700" checksum="88B38B48BD2C746C" modified="2009-10-13" version="1">MKFTTILAAAALTLTVSAKSPLPPPRPLLEGTVNSDRDCKKSITKWTIDENAHDRCVVFDEELEGVEDYAVKSLRVDALNNDKCGLWVYSDHGCHMAARRVEPKTCVVADRWGWRSYAIFCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSX8</accession>
    <name>C7YSX8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_69757</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the methylcitrate cycle that catalyzes the synthesis of (2S,3S)-2-methylcitrate from propionyl-CoA and oxaloacetate. Plays an important role in detoxification of propionyl-CoA, an inhibitor of both primary and secondary metabolism. Also has citrate synthase activity using as substrates acetyl-CoA and oxaloacetate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>propanoyl-CoA + oxaloacetate + H2O = (2S,3S)-2-methylcitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23780"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:58853"/>
            <dbReference type="EC" id="2.3.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051027.1">
        <property type="nucleotide sequence ID" value="XM_003050981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSX8"/>
    <dbReference type="STRING" id="660122.C7YSX8"/>
    <dbReference type="GeneID" id="9668438"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_69757"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_69757"/>
    <dbReference type="eggNOG" id="KOG2617">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022049_2_0_1"/>
    <dbReference type="InParanoid" id="C7YSX8"/>
    <dbReference type="OMA" id="IDHGFNA"/>
    <dbReference type="OrthoDB" id="8017587at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050440">
        <property type="term" value="F:2-methylcitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019629">
        <property type="term" value="P:propionate catabolic process, 2-methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF15">
        <property type="entry name" value="CITRATE SYNTHASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU45314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="472" mass="52058" checksum="665DD052A0D54BB9" modified="2009-10-13" version="1">MALNLTTSRRALGSLKPLTRAAFVGARGYATAEPDLKATLREAIPAKRELLKKVKAHANKTIGEVKVENTLGGMRGLKAMVWEGSVLDANEGIRFHGRTIKDCQKELPKGKTGTEMLPEAMFWLLLTGQVPSTNQIRGFSRELAEKAQIPEFVAKMLDNFPKDLHPMTQFAMAVSALNYESKFAKAYEQGLNKADYWEPTFDDCISLLAKLPTIAAKIYQNSYRGGGALPAEVDLEQDWSYNFAAMLGKGGKENENFQDLLRLYLALHGDHEGGNVSAHATHLVGSALSDPFLSYSAGLQGLAGPLHGLAAQEVLRWILQMKEAIPAKYTEQDVNDYLWSTLNSGRVVPGYGHAVLRKPDPRFEALMDYAAARPEIAQDPVFQLVQKNSRIAPEVLKKHGKTKNPYPNVDSSSGVLFHHYGFHETLYYTATFGVSRGLGPLAQLVWDRALGLPIERPKSINLEGILKQVEGQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-01-11" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7YTF5</accession>
    <name>CYNS_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyanate hydratase</fullName>
            <shortName evidence="1">Cyanase</shortName>
            <ecNumber evidence="1">4.2.1.104</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cyanate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Cyanate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">CYN1</name>
        <name type="ORF">NECHADRAFT_102802</name>
    </gene>
    <organism>
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cyanate + hydrogencarbonate + 3 H(+) = NH4(+) + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:11120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29195"/>
            <dbReference type="EC" id="4.2.1.104"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyanase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.104" evidence="1"/>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049949.1">
        <property type="nucleotide sequence ID" value="XM_003049903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YTF5"/>
    <dbReference type="SMR" id="C7YTF5"/>
    <dbReference type="STRING" id="660122.C7YTF5"/>
    <dbReference type="EnsemblFungi" id="NechaT102802">
        <property type="protein sequence ID" value="NechaP102802"/>
        <property type="gene ID" value="NechaG102802"/>
    </dbReference>
    <dbReference type="GeneID" id="9665728"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102802"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102802"/>
    <dbReference type="eggNOG" id="ENOG502RY7W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103452_0_0_1"/>
    <dbReference type="InParanoid" id="C7YTF5"/>
    <dbReference type="OMA" id="YELVMIN"/>
    <dbReference type="OrthoDB" id="10019422at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008824">
        <property type="term" value="F:cyanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00559">
        <property type="entry name" value="Cyanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1160.10">
        <property type="entry name" value="Cyanate lyase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00535">
        <property type="entry name" value="Cyanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008076">
        <property type="entry name" value="Cyanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003712">
        <property type="entry name" value="Cyanate_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036581">
        <property type="entry name" value="Cyanate_lyase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00673">
        <property type="entry name" value="cynS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186">
        <property type="entry name" value="CYANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186:SF2">
        <property type="entry name" value="CYANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02560">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001263">
        <property type="entry name" value="Cyanate_hydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01693">
        <property type="entry name" value="CYANASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01116">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55234">
        <property type="entry name" value="Cyanase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000403255" description="Cyanate hydratase">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03139"/>
        </source>
    </evidence>
    <sequence length="164" mass="18108" checksum="C3CF6A30EDF9E601" modified="2009-10-13" version="1">MANEGRIATLDSTVADRLPVYSKLLFDGKAAKGLSFETIAKHLDRSEVACAALFYGQATASPEDIDRLSDLLEISKETLTTQMTGFPNRGQASPMPPVEPLIYRLYEIVQNYGYAYKAILNEKFGDGIMSAICFSTTVDKEVDEAGAPWVVITLKGKWLPFSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7YU32</accession>
    <name>C7YU32_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_48479</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050445.1">
        <property type="nucleotide sequence ID" value="XM_003050399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YU32"/>
    <dbReference type="STRING" id="660122.C7YU32"/>
    <dbReference type="GeneID" id="9674841"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_48479"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_48479"/>
    <dbReference type="eggNOG" id="KOG4373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016103_0_0_1"/>
    <dbReference type="InParanoid" id="C7YU32"/>
    <dbReference type="OMA" id="DVRSSNW"/>
    <dbReference type="OrthoDB" id="1920326at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06141">
        <property type="entry name" value="WRN_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051132">
        <property type="entry name" value="3-5_Exonuclease_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620">
        <property type="entry name" value="3-5 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620:SF104">
        <property type="entry name" value="EXONUCLEASE 3'-5' DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="4">
        <location>
            <begin position="166"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU44732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="542" mass="61466" checksum="1A16A0FF9ECCA389" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7YV41</accession>
    <name>C7YV41_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PWI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_48591</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050227.1">
        <property type="nucleotide sequence ID" value="XM_003050181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YV41"/>
    <dbReference type="STRING" id="660122.C7YV41"/>
    <dbReference type="GeneID" id="9674663"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_48591"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_48591"/>
    <dbReference type="eggNOG" id="KOG2253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009938_0_0_1"/>
    <dbReference type="InParanoid" id="C7YV41"/>
    <dbReference type="OMA" id="DGCVNKK"/>
    <dbReference type="OrthoDB" id="6275295at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052768">
        <property type="entry name" value="RBM25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806">
        <property type="entry name" value="RBM25 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806:SF4">
        <property type="entry name" value="RNA-BINDING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="497"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="370"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU44514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="590" mass="66960" checksum="3294CA96E1B461F2" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVH0</accession>
    <name>C7YVH0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF2961 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_48881</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050689.1">
        <property type="nucleotide sequence ID" value="XM_003050643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVH0"/>
    <dbReference type="GeneID" id="9675085"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_48881"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_48881"/>
    <dbReference type="eggNOG" id="ENOG502SKR2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039495_0_0_1"/>
    <dbReference type="InParanoid" id="C7YVH0"/>
    <dbReference type="OMA" id="WPTICGT"/>
    <dbReference type="OrthoDB" id="3426554at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021345">
        <property type="entry name" value="DUF2961"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11175">
        <property type="entry name" value="DUF2961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU44976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="52333" checksum="BA858E551C7E1755" modified="2009-10-13" version="1">MNFSSSLGSDLLSNAAKLKTARTGRVSSWDHSGLNEDAWVIQPGETAVLADLEGPGSITHLWFVQTCRRIVGPGLIPYSKSGVAMMEVHNALGLNYEVSDPDYYRKVLIKMYWDDSETPNVVAPIGDFFCVGHSMAANFQSLPFTVSVKPSEEKKFGGAAAFNCYLPMPFNKRARIEIENQNDQAYFQYFYIDYELFPEPLSKDTLFFHAHWRRENPTNGWAPESIQTNSLETQVPNLDGKGNYVILETEGAGQYIGCNQSVAHFQATWWGEGDDMIFIDDDTWPPSMHGTGGEDYFSQGWGMQKNAYPFCGTIIHEEDVPNHQVSYRWHLADPVRFSKKIRVTMETGHANHLRDDWSTTAYWYQTLPGPKLEILPVEGRIPRKPDFPAGTHPALPQLENLDPQKKAMVEQSKERMDAFVQDRDVWLERRARDSRERAKKNIEHAKDIRRRFLEGLKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVQ5</accession>
    <name>C7YVQ5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Activator of Hsp90 ATPase homologue 1/2-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_74041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049751.1">
        <property type="nucleotide sequence ID" value="XM_003049705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVQ5"/>
    <dbReference type="GeneID" id="9677122"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74041"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74041"/>
    <dbReference type="eggNOG" id="ENOG502T4MY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108923_0_0_1"/>
    <dbReference type="InParanoid" id="C7YVQ5"/>
    <dbReference type="OMA" id="RLPRWFL"/>
    <dbReference type="OrthoDB" id="5004612at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="ASHA1/2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Activator of Hsp90 ATPase homologue 1/2-like C-terminal" evidence="2">
        <location>
            <begin position="40"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU44038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="203" mass="22443" checksum="3D2629532B2CB2AD" modified="2009-10-13" version="1">MNLDQQLTAVSRTVERTTLESGDEGRIITISQTFDIDAPTLWETCTKPDKIKQFFSPVSGNLSVNGRFQVENNASGIIEKCVPPSNFRMSWEFGGSTSWVEVCIRKVSETQSRLELSHTAPVDKHWEEYGAGAGGVGWEMSFAGLAYHLKGVKVRPEWFGQDETKTYLAKCSEAWGGAAVLGGEDPEVVKERVERTTGFYVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7YW40</accession>
    <name>C7YW40_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_29800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU43901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049614.1">
        <property type="nucleotide sequence ID" value="XM_003049568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YW40"/>
    <dbReference type="GeneID" id="9677189"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_29800"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_29800"/>
    <dbReference type="eggNOG" id="ENOG502RS6K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007446_0_0_1"/>
    <dbReference type="InParanoid" id="C7YW40"/>
    <dbReference type="OMA" id="KEPRWLH"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="602"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="643"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="237"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="547"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="550"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU43901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="731" mass="81358" checksum="9919086654CC46B5" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7YX85</accession>
    <name>C7YX85_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_82927</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049256.1">
        <property type="nucleotide sequence ID" value="XM_003049210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YX85"/>
    <dbReference type="STRING" id="660122.C7YX85"/>
    <dbReference type="GeneID" id="9666238"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82927"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82927"/>
    <dbReference type="eggNOG" id="ENOG502SUCM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_774081_0_0_1"/>
    <dbReference type="InParanoid" id="C7YX85"/>
    <dbReference type="OMA" id="SECANIG"/>
    <dbReference type="OrthoDB" id="2328572at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF31">
        <property type="entry name" value="MONODICTYPHENONE CLUSTER TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU43543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="358" mass="38219" checksum="462CF7CF4D7EA5D9" modified="2009-10-13" version="1">MSNIQHESHNRAPRLQTRFRSSCDACGQAKIKCDRGRPACSRCIAQGLGCVYGVSRKAGKPPRRRLASPLQVRSSPGMPEIPEIGLTCNDQGDLDMMLGLAESNLILDDPFSTSHDIFQPWLSLNNLESPAILEPAERSTATTPPITAARQFCTQESKDIMRRLYCANPSAPISDGVPARTLDLDSVLTRNRDVVGRLGLLLKCPLSRVLLWYKQAISNTNDTGMSYPPTPGAPGSTTSSTSGDSLSSSGAGATSDKMGVSVLRTALTVGTFQSHDHDLQAALTNTLIQSELKRVGSLITVFLSLGTETYDPGAACPAAEELGTNLADKNLVASLGAWLQTEYRGIVAKARSSSTAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYA9</accession>
    <name>C7YYA9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_83627</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU42973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048686.1">
        <property type="nucleotide sequence ID" value="XM_003048640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYA9"/>
    <dbReference type="GeneID" id="9665792"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83627"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83627"/>
    <dbReference type="eggNOG" id="ENOG502T5ZM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042074_0_0_1"/>
    <dbReference type="InParanoid" id="C7YYA9"/>
    <dbReference type="OMA" id="CETVAMA"/>
    <dbReference type="OrthoDB" id="5060470at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="11"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU42973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="441" mass="48630" checksum="9209F83E4D82359D" modified="2009-10-13" version="1">MSSPNQLAPGSCFTCRRQKQRCDRLLPQCSRCTSKAIACDYKATTTSQTSPFSPGTQIEAAVLVHLRDSCSFDLTPLAERYLIWAACASDSVGDEGSHAQPTLSTLAQDIFSAGGANLHTMIETYFAIAHSWLPILDKEQLYLDTDHLFRYPGYQNDVTALLLVCIYIFIQQPCQHPNHSVRSALYRTARRLFFLLQTSAHVSKIALLQSGILLVAYELGHGMSKDAYGTLGVCTSLAQQLSLEPTGCDRDMIQRPEITQLDLCWSGIVLLDRTIMLSDFEYHVPQSVGFNHHFASAAVAKASDEDLYGDDLARKFLARAKVALHIGKILDAVGKSFPLCEALAMSLSALAILYCLRDKQISTLSSPATRSAVQCVHNIVFDTFHTEGEIGAAIRMDRLYVDGLAGEDLKELRSTLESFSTRWKLGESFIEALNAGREDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYB5</accession>
    <name>C7YYB5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Very-long-chain 3-oxoacyl-CoA reductase</fullName>
            <ecNumber evidence="12">1.1.1.330</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">3-ketoacyl-CoA reductase</fullName>
            <shortName evidence="12">3-ketoreductase</shortName>
            <shortName evidence="12">KAR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Microsomal beta-keto-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_47054</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="EC" id="1.1.1.330"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endoplasmic reticulum membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.330" evidence="12"/>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048873.1">
        <property type="nucleotide sequence ID" value="XM_003048827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYB5"/>
    <dbReference type="FunCoup" id="C7YYB5">
        <property type="interactions" value="810"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YYB5"/>
    <dbReference type="GeneID" id="9665795"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_47054"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_47054"/>
    <dbReference type="eggNOG" id="KOG1014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_38_0_1"/>
    <dbReference type="InParanoid" id="C7YYB5"/>
    <dbReference type="OMA" id="LVAPGMM"/>
    <dbReference type="OrthoDB" id="5545019at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045703">
        <property type="term" value="F:ketoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141040">
        <property type="term" value="F:very-long-chain 3-oxoacyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000317">
        <property type="entry name" value="Very-long-chain 3-oxoacyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03107">
        <property type="entry name" value="3_ketoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027533">
        <property type="entry name" value="3_ketoreductase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086:SF2">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086">
        <property type="entry name" value="VERY-LONG-CHAIN 3-OXOOACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0521">NADP</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU43160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="334" mass="36653" checksum="DB2F21B46CED70D8" modified="2009-10-13" version="1">MDAISNFFQRVPQPLQWSLAGIGALVLGSKLLSYLQLVLSAFVLGGTNLRKYGKPGTWAVVTGASDGLGKEYALQLAAKGFNLVLVSRTLSKLESLAAEIQEKFPGKGLEIKSLAMDFSQNNDADYERLAELIQGLDVGILINNVGQSHSIPVSFLDTAKEELQNIITINCIGTLRVTQTVAPILKQRKRGLILTMGSFGGWTPTPYLATYSGSKAFLQQWSNALSSELADDNVDVYLVLSHLVTTAMSKVRRPSLLVPNARNFVKAALGKVGLGGYQTAPNTYTPWWSHSFMLWLIENVPGVNSPITIFYNKKMHVDIRRRALRKAAREAKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYQ1</accession>
    <name>C7YYQ1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_83765</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 22 family. PIGB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048753.1">
        <property type="nucleotide sequence ID" value="XM_003048707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYQ1"/>
    <dbReference type="FunCoup" id="C7YYQ1">
        <property type="interactions" value="859"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YYQ1"/>
    <dbReference type="GeneID" id="9665942"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83765"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83765"/>
    <dbReference type="eggNOG" id="KOG1771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012353_1_1_1"/>
    <dbReference type="InParanoid" id="C7YYQ1"/>
    <dbReference type="OMA" id="HHMVFNN"/>
    <dbReference type="OrthoDB" id="416834at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF4">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU43040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="607" mass="68675" checksum="30D229DBD68DC191" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYU2</accession>
    <name>C7YYU2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_47027</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048771.1">
        <property type="nucleotide sequence ID" value="XM_003048725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYU2"/>
    <dbReference type="STRING" id="660122.C7YYU2"/>
    <dbReference type="GeneID" id="9665618"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_47027"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_47027"/>
    <dbReference type="eggNOG" id="ENOG502QR2H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009768_0_0_1"/>
    <dbReference type="InParanoid" id="C7YYU2"/>
    <dbReference type="OMA" id="HQNMLFL"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF27">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="175"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="94"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="285"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="817"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1055"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="852"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1064"/>
            <end position="1074"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU43058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1074" mass="117517" checksum="56621E16B1257477" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYZ7</accession>
    <name>C7YYZ7_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_71164</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048801.1">
        <property type="nucleotide sequence ID" value="XM_003048755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYZ7"/>
    <dbReference type="FunCoup" id="C7YYZ7">
        <property type="interactions" value="911"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YYZ7"/>
    <dbReference type="GeneID" id="9665990"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_71164"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_71164"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_21_3_1"/>
    <dbReference type="InParanoid" id="C7YYZ7"/>
    <dbReference type="OMA" id="GDEPYTF"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01874">
        <property type="entry name" value="Cdc42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000236">
        <property type="entry name" value="Cell division control protein 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037874">
        <property type="entry name" value="Cdc42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU43088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="198" mass="21938" checksum="C5D5FC536E70F967" modified="2009-10-13" version="1">MTVVATIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGDEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVTSPASFENVREKWFPEVRHHCPGVPCLIVGTQVDLRDDPSVRDKLSKQKMAPVRREDGERMAKDLGAVKYVECSALTQYKLKDVFDEAIVAALEPPVPKKAGSRGHKCLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZI8</accession>
    <name>C7YZI8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_95742</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048326.1">
        <property type="nucleotide sequence ID" value="XM_003048280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZI8"/>
    <dbReference type="GeneID" id="9667599"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95742"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95742"/>
    <dbReference type="eggNOG" id="ENOG502SYFF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055491_7_0_1"/>
    <dbReference type="InParanoid" id="C7YZI8"/>
    <dbReference type="OMA" id="VTWHNDS"/>
    <dbReference type="OrthoDB" id="2993351at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052355">
        <property type="entry name" value="CENP-V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620:SF1">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620">
        <property type="entry name" value="CENTROMERE PROTEIN V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="12"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU42613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="156" mass="17552" checksum="81897D66E5F1B904" modified="2009-10-13" version="1">MATEEPKAEATYEAGCHCGYISLSVTLSPPLPEHEVLHCNCSICRRGGYLLVYPFHSKVTWHHDSEKRVSRYEFNTKSRDHMFCPKCGASIGIDFERFKPDKPYYGISVRQFNDVDLDSLKYKKFDGIHKMVPAGDLSGVEINAETGEPTSSGSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1J2</accession>
    <name>C7Z1J2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH TFE/IIEalpha-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_72382</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU41830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047543.1">
        <property type="nucleotide sequence ID" value="XM_003047497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1J2"/>
    <dbReference type="FunCoup" id="C7Z1J2">
        <property type="interactions" value="141"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z1J2"/>
    <dbReference type="GeneID" id="9671678"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_72382"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_72382"/>
    <dbReference type="eggNOG" id="KOG2593">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035744_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z1J2"/>
    <dbReference type="OMA" id="DAIKWKV"/>
    <dbReference type="OrthoDB" id="361102at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF7">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="228"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="322"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="334"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="369"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU41830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="384" mass="43394" checksum="F8D73C1727C20765" modified="2009-10-13" version="1">MDLAVTLIKSVMRAFYQTRDILVIDALILHEALRDDDLAYLMAINTKDLHKICGKLREDRFLTVHTRSELREGNPRPSNRTWYYINYRNTIDAIKWRVYTIDKEVQGTTQVASEKKEFFCSFCKAEWTMMEVLDNSGPDGFLCHRCHHTLTFEADRTSTGHEQSTRLNSQFKFISELLPKIDAVHIPECDFDRAFANARPVKRDATHQRAQTVAADAGANRPMAVKGLTNTGPQSIAVNISTSDGPTDAEKAEEQARKEKIAKQNALPSWMSNSTVTGESFSATGTPGTTTTIKKEAAANSSLATAPNTKATTQIDDIFEKLKAEQAAERAREEDEFGSEEEDEDEDEFEDRQAKRVKVEPEPVIKKEEEEDEDSEEEIEFEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1U1</accession>
    <name>C7Z1U1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Succinate dehydrogenase cytochrome b subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_50762</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU42060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047773.1">
        <property type="nucleotide sequence ID" value="XM_003047727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1U1"/>
    <dbReference type="SMR" id="C7Z1U1"/>
    <dbReference type="FunCoup" id="C7Z1U1">
        <property type="interactions" value="395"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z1U1"/>
    <dbReference type="GeneID" id="9671731"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_50762"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_50762"/>
    <dbReference type="eggNOG" id="KOG0449">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094691_0_1_1"/>
    <dbReference type="InParanoid" id="C7Z1U1"/>
    <dbReference type="OMA" id="KVGQVWF"/>
    <dbReference type="OrthoDB" id="588261at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018495">
        <property type="entry name" value="Succ_DH_cyt_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01001">
        <property type="entry name" value="SDH_CYT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU42060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="20407" checksum="66A2B63E9A00FF77" modified="2009-10-13" version="1">MNLQRVGLSAIRAGTARPNVFFSQDVPKLAVARLLSQHSRPPTIVRMSAKDGHDILVKQRLNRPVTPHLSIYKIGQVWFSASAWTRITGIALGGTAYLTLCAYAVAPLLGLPFDSAAVASAFGSLPFVVKAAVKFGLLGFPFSYHFVNGVRHLVFDLGFGYKKAQFRKSEAATWTLSIIGGLVLAFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z2E4</accession>
    <name>C7Z2E4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_97716</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047178.1">
        <property type="nucleotide sequence ID" value="XM_003047132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z2E4"/>
    <dbReference type="STRING" id="660122.C7Z2E4"/>
    <dbReference type="GeneID" id="9676350"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_97716"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_97716"/>
    <dbReference type="eggNOG" id="ENOG502QUV4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_4_2_1"/>
    <dbReference type="InParanoid" id="C7Z2E4"/>
    <dbReference type="OMA" id="VHNTGHD"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988770" description="FAD-binding PCMH-type domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="186"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU41465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="654" mass="70658" checksum="A2984E2CAB39B572" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z3D5</accession>
    <name>C7Z3D5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_54105</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047349.1">
        <property type="nucleotide sequence ID" value="XM_003047303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z3D5"/>
    <dbReference type="STRING" id="660122.C7Z3D5"/>
    <dbReference type="GeneID" id="9676038"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_54105"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_54105"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_4_1"/>
    <dbReference type="InParanoid" id="C7Z3D5"/>
    <dbReference type="OMA" id="WCELYIA"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU41636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="57856" checksum="066758834B7746A0" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z458</accession>
    <name>C7Z458_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_83489</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046972.1">
        <property type="nucleotide sequence ID" value="XM_003046926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z458"/>
    <dbReference type="STRING" id="660122.C7Z458"/>
    <dbReference type="GeneID" id="9675620"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83489"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83489"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_4_1_1"/>
    <dbReference type="InParanoid" id="C7Z458"/>
    <dbReference type="OMA" id="KGWVKLR"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF213">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="128"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="4">
        <location>
            <begin position="490"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="614"/>
            <end position="615"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU41259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="634" mass="68431" checksum="E96C08DFCE5E57AB" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z459</accession>
    <name>C7Z459_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_46163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047135.1">
        <property type="nucleotide sequence ID" value="XM_003047089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z459"/>
    <dbReference type="GeneID" id="9675309"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_46163"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_46163"/>
    <dbReference type="eggNOG" id="ENOG502RYZ8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009377_1_1_1"/>
    <dbReference type="InParanoid" id="C7Z459"/>
    <dbReference type="OMA" id="NLFVEQH"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="2">
        <location>
            <begin position="334"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU41422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="700" mass="77467" checksum="2B88905E08F92D6D" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z498</accession>
    <name>C7Z498_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="16">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">NECHADRAFT_45968</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="16"/>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046990.1">
        <property type="nucleotide sequence ID" value="XM_003046944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z498"/>
    <dbReference type="STRING" id="660122.C7Z498"/>
    <dbReference type="GeneID" id="9675642"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45968"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45968"/>
    <dbReference type="eggNOG" id="KOG0538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020639_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z498"/>
    <dbReference type="OMA" id="SKAPFIM"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF104">
        <property type="entry name" value="CYTOCHROME B2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 19" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="21">
        <location>
            <begin position="27"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="106"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EEU41277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="408" mass="44384" checksum="15B46BB004F89D50" modified="2009-10-13" version="1">MSDLAAMESETPNIPPPRVVELPPSVPKLEEILSANDFALAAQKALTPKAWAFYSSAATDLITVNKNRELIRRVMLRPRILRNVSSVRIDRKILGLDSRAPFIMCPAAMATLAHPDGELGWSRAAASEGIFEIISSNASYSLPSIIAAAPPGHPFFLQLYVNSNRPKTIELLRRARSLGIKAIFVTVDAPVPGKREADERAAQDVVIKSEMSGSESSKDNKGSGLGRLMGQYIDKSLNWEDLKWIREESSVPIVLKGVQTVEDVKLAVEYGVDGVMLSNHGGRSLDGAQASILILLEVRKRFPEAFQHLEIFIDGGFERGSDILKAIALGATAVGIARPFLYSLVYGQKGVEHLSQILKDELETSLRLAGLTSLDQATPDLVNTLDVDYLVPSRGAESCPMSGMRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4I8</accession>
    <name>C7Z4I8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_76537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046644.1">
        <property type="nucleotide sequence ID" value="XM_003046598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4I8"/>
    <dbReference type="GeneID" id="9668504"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76537"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76537"/>
    <dbReference type="HOGENOM" id="CLU_2250786_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z4I8"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU40931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="104" mass="10875" checksum="8F1ED4AF5990F375" modified="2009-10-13" version="1">MSCDPTACLARVKLGQQHPRAFTKQARLHVQHGIFAAAIPSPHEVLRPAKPGASLGSANDLGAPPELSGPLDGARLQASACLLVSRVVAVIVLFIMYDATPIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4U4</accession>
    <name>C7Z4U4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_76639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046120.1">
        <property type="nucleotide sequence ID" value="XM_003046074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4U4"/>
    <dbReference type="GeneID" id="9678503"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76639"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76639"/>
    <dbReference type="HOGENOM" id="CLU_1321207_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z4U4"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU40407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="208" mass="20349" checksum="9DB23A89D52216A2" modified="2009-10-13" version="1">MLGGGGGGGNLDLSKLTPAQLHALGAGLAGRPSGPAAGVTKTQTTAQPGLGTSKFARARREKAAAKAASSSSSSTTSVSTSSASAEKEAIRPASAAEVPESEPEPKPEAAAAKSSEAVPEVAVDYIDCNLGPGSNPSLPASSSAALKTSPVIIPVFEKTAAAATSSAAVEVPKPEATAAKSSEAMPEAAVDFVDCSLGEKVDEEMTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z561</accession>
    <name>C7Z561_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">D-3-phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="10">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_99347</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="10"/>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046178.1">
        <property type="nucleotide sequence ID" value="XM_003046132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z561"/>
    <dbReference type="STRING" id="660122.C7Z561"/>
    <dbReference type="GeneID" id="9678284"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_99347"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_99347"/>
    <dbReference type="eggNOG" id="KOG0068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_8_1_1"/>
    <dbReference type="InParanoid" id="C7Z561"/>
    <dbReference type="OMA" id="NIAGMQV"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04902">
        <property type="entry name" value="ACT_3PGDH-xct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12173">
        <property type="entry name" value="PGDH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.90:FF:000003">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000021">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006236">
        <property type="entry name" value="PGDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045626">
        <property type="entry name" value="PGDH_ASB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01327">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938:SF22">
        <property type="entry name" value="D-3-PHOSPHOGLYCERATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19304">
        <property type="entry name" value="PGDH_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="Serine metabolism enzymes domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="11">
        <location>
            <begin position="483"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU40465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="568" mass="60082" checksum="B7C98760E7E84044" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z5E9</accession>
    <name>C7Z5E9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_33795</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046221.1">
        <property type="nucleotide sequence ID" value="XM_003046175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z5E9"/>
    <dbReference type="STRING" id="660122.C7Z5E9"/>
    <dbReference type="GeneID" id="9678607"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_33795"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_33795"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_14_0_1"/>
    <dbReference type="InParanoid" id="C7Z5E9"/>
    <dbReference type="OMA" id="KEPWFTK"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="4">
        <location>
            <begin position="14"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="5">
        <location>
            <begin position="105"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU40508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="29776" checksum="05AE9D9BD6EE48A4" modified="2009-10-13" version="1">MSRPTGLIASKGVELLTWGTPNGVKATVLLEELRDAYGKDYTMQAVNISQNIQKEPWFTALNPNGRIPVLVDHDNSDLAVFEGNAILSYLTRKYDPEHKFSFNIDDDDYTRAESWIGWQHGGLGPMMGQAGHFLNAKEVIPYGIQRYVGETERLIGILNDRLTSRDFVVGPDRGRYSIADIAMVGWVNGLPRSTISWEQFPHVRDWLARLLERPAVRRGLALPSGEEKPTGLDPVSDKVQKERDELKKVVDKAKEQYGYKYSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z5H1</accession>
    <name>C7Z5H1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mandelate racemase/muconate lactonizing enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_66837</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046231.1">
        <property type="nucleotide sequence ID" value="XM_003046185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z5H1"/>
    <dbReference type="STRING" id="660122.C7Z5H1"/>
    <dbReference type="GeneID" id="9678619"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_66837"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_66837"/>
    <dbReference type="eggNOG" id="ENOG502QU7C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030273_2_0_1"/>
    <dbReference type="InParanoid" id="C7Z5H1"/>
    <dbReference type="OMA" id="SGAIDVC"/>
    <dbReference type="OrthoDB" id="14161at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050023">
        <property type="term" value="F:L-fuconate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03324">
        <property type="entry name" value="rTSbeta_L-fuconate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000007">
        <property type="entry name" value="Mitochondrial enolase superfamily member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034610">
        <property type="entry name" value="L-fuconate_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046945">
        <property type="entry name" value="RHMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794">
        <property type="entry name" value="ENOLASE SUPERFAMILY, MANDELATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794:SF58">
        <property type="entry name" value="MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00111">
        <property type="entry name" value="L-fuconate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00270">
        <property type="entry name" value="L-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="5">
        <location>
            <begin position="200"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU40518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="450" mass="50115" checksum="634A8401C51A7325" modified="2009-10-13" version="1">MAEITITGWRTRDVRFPTSLDGTGSDAMNAAGNYSSAYCILETDSKYTGHGMTFTIGRGNDIICAAINHVAERLKGKTLSSLVLDWGKTWRYLVNDSQLRWIGPEKGVIHLALGAVVNAVWDLWAKTLNKPVWRIVADMSPEEFVSCIDFRYITDAITPEEAVAMLKEQEATKPQRLEDALNSRAVPAYTTSAGWLGYGEDKMKSLLQETLNAGYRHFKVKVGGDIERDRKRLGIAREVIGYDKGNVLMTDANQVWSVPEAIDYMKQLADFKPWFIEEPTSPDDVLGHKAVRDALKPYGIGVATGEMCQNRVIFKQLLQTGAIDVCQIDACRMGGVNEVLAVLLMAKKFGVPIVPHSGGVGLPEYTQHLSTIDYVVVSGKLSVLEYVDHLHEHFLHPSVIKDGYYTTPTEPGYSVEMKPESMDRYLYPGEKGVSWWTSEEARVILDGEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z5Q1</accession>
    <name>C7Z5Q1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_66003</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU39990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045703.1">
        <property type="nucleotide sequence ID" value="XM_003045657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z5Q1"/>
    <dbReference type="GeneID" id="9678118"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_66003"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_66003"/>
    <dbReference type="eggNOG" id="ENOG502QQNB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033094_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z5Q1"/>
    <dbReference type="OMA" id="FYLFHNY"/>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="3">
        <location>
            <begin position="135"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU39990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="478" mass="53713" checksum="AA077B99A9EAA8B2" modified="2009-10-13" version="1">MASTAVPRQNPALRRTVTSTTATDSETSAAVSPSDSPRPSASSTSLSSLSEVDIAKPKSSYGRLIDTYGNEFEVPDFTIKDIHDAIPKHCFKRSAIRGYGYILRDIVLLTTTFTIWHNFVTPEYIPSTPARAGLWAVYTVLQGLFGTGLWVIAHECGHGAFSDSRLVNDITGWVLHSSLLVPYFSWQISHRKHHKATGNMERDMVFVPRTREQQATRLGKMAHELAHLTEETPAFTLLMLVMQQLVGWPNYLLTNVTGHNFHERQREGRGKGKKNGLGGGVNHFDPRSPLYENRDAKLIVLSDIGIGLVATGLYFLVQKFGFYNMAIWYFVPYLWVNHWLVAITFLQHTDPTLPHYHNEEWNFVRGAAATIDREMGFIGRHLLHGIIETHVLHHYVSSIPFYNADEATEAIKPVMGKHYRADVKDGPRGFIRAMYNSARMCQWVEPSAEAEGAGKNILFFRNRNNLGTKPAIIDPPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6B5</accession>
    <name>C7Z6B5_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_76044</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the synembryn family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046379.1">
        <property type="nucleotide sequence ID" value="XM_003046333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6B5"/>
    <dbReference type="GeneID" id="9668573"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76044"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76044"/>
    <dbReference type="eggNOG" id="KOG4464">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_397450_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z6B5"/>
    <dbReference type="OrthoDB" id="5585685at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019318">
        <property type="entry name" value="Gua_nucleotide_exch_fac_Ric8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425:SF5">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10165">
        <property type="entry name" value="Ric8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="208"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="624"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU40666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="693" mass="76704" checksum="03F2C9EED9EE6319" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6F6</accession>
    <name>C7Z6F6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_76085</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046398.1">
        <property type="nucleotide sequence ID" value="XM_003046352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6F6"/>
    <dbReference type="STRING" id="660122.C7Z6F6"/>
    <dbReference type="GeneID" id="9667958"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76085"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76085"/>
    <dbReference type="eggNOG" id="KOG3857">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007207_0_2_1"/>
    <dbReference type="InParanoid" id="C7Z6F6"/>
    <dbReference type="OMA" id="GTRIGMQ"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08192">
        <property type="entry name" value="MAR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF107">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06800)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="2">
        <location>
            <begin position="29"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="3">
        <location>
            <begin position="211"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU40685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="416" mass="45101" checksum="4D2E0E69888C3735" modified="2009-10-13" version="1">MSFEFGIETFRPAFDDRETPKISYGLRFPEACLRHCRDTFSSSRVYIICSKSLSQATDALDRLTAALGDRVAGVRIGISPHTPIAQVLEVVKDARHRDVDCLVTLGAGSLTDAAKLVRLALANSAATEEAMNTLWGTAESNLALRKDIVKPTIPLIHIPTSLSGGEYQAIAGGTESQGHAKRTFHCERVDPELVIQDPELCLTTPEWVWLSTGIRSVDHCVETLCSLLSNEKGDTWAKRGLPKLISGLLESKANPKSLQARHLCQLGVIEAMCAVSSGVPLGASHAIGHQLGPLGVGHGETSCILLPAVCKFNLKYKANVDRQAMVKDLLLGQEEVKQLLKSKALDGKEPDLGDILAAVISALEMPRSLEEVGIGQESLDTLARNSLEDIWIRTNAVPITEESQVREILDMCAKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z887</accession>
    <name>C7Z887_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_1681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045539.1">
        <property type="nucleotide sequence ID" value="XM_003045493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z887"/>
    <dbReference type="STRING" id="660122.C7Z887"/>
    <dbReference type="GeneID" id="9672568"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_1681"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_1681"/>
    <dbReference type="eggNOG" id="ENOG502QR47">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004835_2_2_1"/>
    <dbReference type="InParanoid" id="C7Z887"/>
    <dbReference type="OMA" id="MNSECAD"/>
    <dbReference type="OrthoDB" id="4356994at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU39826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="603" mass="68019" checksum="A51A18A53D6B0AF1" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8A6</accession>
    <name>C7Z8A6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_39190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045677.1">
        <property type="nucleotide sequence ID" value="XM_003045631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8A6"/>
    <dbReference type="STRING" id="660122.C7Z8A6"/>
    <dbReference type="GeneID" id="9672577"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_39190"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_39190"/>
    <dbReference type="eggNOG" id="KOG0733">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004471_6_2_1"/>
    <dbReference type="InParanoid" id="C7Z8A6"/>
    <dbReference type="OMA" id="DDLICFP"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF2">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="1">
        <location>
            <begin position="347"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="597" mass="67128" checksum="FE9B06C49BB79EBB" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8N9</accession>
    <name>C7Z8N9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_70137</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the complex I NDUFS4 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045112.1">
        <property type="nucleotide sequence ID" value="XM_003045066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8N9"/>
    <dbReference type="STRING" id="660122.C7Z8N9"/>
    <dbReference type="GeneID" id="9673534"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_70137"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_70137"/>
    <dbReference type="eggNOG" id="KOG3389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077196_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z8N9"/>
    <dbReference type="OMA" id="YDATIDH"/>
    <dbReference type="OrthoDB" id="3089at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.190:FF:000001">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 21 kDa subunit mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.190">
        <property type="entry name" value="atu1810 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006885">
        <property type="entry name" value="NADH_UbQ_FeS_4_mit-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038532">
        <property type="entry name" value="NDUFS4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219:SF8">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04800">
        <property type="entry name" value="NDUS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="32"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU39399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="197" mass="22158" checksum="0991CC55C1F694D4" modified="2009-10-13" version="1">MASLRSQRAAQLLRGAIAPRVALSATPRRFQSSVTQASGTVPAPTTNEPDYNIQADKATSTYTPVPKSLQEGSEEILPAATISGAPMELQARTVRIYQETKPATQSGEWRGQRWRMDWDILPKGHRWENPLMGWQSSGDFMQGTHINFKSKEDAIHFAEKQGYEYFVQEPNSRKFAPKAYANNFLYSAGKLKHIRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z904</accession>
    <name>C7Z904_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-protein ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_94222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU38916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044629.1">
        <property type="nucleotide sequence ID" value="XM_003044583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z904"/>
    <dbReference type="STRING" id="660122.C7Z904"/>
    <dbReference type="GeneID" id="9673011"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94222"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94222"/>
    <dbReference type="eggNOG" id="ENOG502S2K4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006057_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z904"/>
    <dbReference type="OMA" id="ETEWESY"/>
    <dbReference type="OrthoDB" id="66726at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="435"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="734"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU38916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="883" mass="96173" checksum="0A5F78DFAEDCE587" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z955</accession>
    <name>C7Z955_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_100832</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045078.1">
        <property type="nucleotide sequence ID" value="XM_003045032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z955"/>
    <dbReference type="GeneID" id="9673164"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100832"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100832"/>
    <dbReference type="eggNOG" id="ENOG502SPDF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055491_3_6_1"/>
    <dbReference type="InParanoid" id="C7Z955"/>
    <dbReference type="OMA" id="FTELDIM"/>
    <dbReference type="OrthoDB" id="2212170at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF30">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03180)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="3"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU39365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="137" mass="14798" checksum="C52505E6CC9B467B" modified="2009-10-13" version="1">MPLSGSCMCGAIAYKSTSDPAVTALCHCLDCQKWTGGPYTTNAVVPEDSFSVTKGTPKHCDITGASGKNNRHFFCPDCGSSLYTRLDVMPGNIVIKAGGLDEGKTNLNNKIDVEFYCRDRLDFVKPIEGAKQEHLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9A5</accession>
    <name>C7Z9A5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="14">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">NECHADRAFT_43706</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:27695"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IlvD/Edd family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14"/>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045182.1">
        <property type="nucleotide sequence ID" value="XM_003045136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9A5"/>
    <dbReference type="STRING" id="660122.C7Z9A5"/>
    <dbReference type="GeneID" id="9673763"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_43706"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_43706"/>
    <dbReference type="eggNOG" id="KOG2448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014271_4_1_1"/>
    <dbReference type="InParanoid" id="C7Z9A5"/>
    <dbReference type="OMA" id="LAWQFNT"/>
    <dbReference type="OrthoDB" id="3851628at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.80:FF:000001">
        <property type="entry name" value="Dihydroxy-acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050165">
        <property type="entry name" value="DHAD_IlvD/Edd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002068">
        <property type="entry name" value="PRK00911.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000:SF13">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="18">
        <location>
            <begin position="70"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="19">
        <location>
            <begin position="412"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EEU39469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="608" mass="65058" checksum="A9AD8565250D7FCB" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9D9</accession>
    <name>C7Z9D9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_81720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045203.1">
        <property type="nucleotide sequence ID" value="XM_003045157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9D9"/>
    <dbReference type="GeneID" id="9673776"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_81720"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_81720"/>
    <dbReference type="HOGENOM" id="CLU_1586922_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z9D9"/>
    <dbReference type="OrthoDB" id="62952at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU39490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="168" mass="19347" checksum="AF8285461DCEB0FF" modified="2009-10-13" version="1">MHPQTNSRFFSLPLKIRIIIQREYLKQHPEIKATGHLLPPIEGRVIKWYKGVSIAHPLMLTCIKMYKEMCPTAFEDLTIRFQPWLKEQLPLRMVLPPPRRCLRNLTLIVDAHYEEMREYQGLALHLLGSPSLEKFTIKGDHGSDWFNGYTSEHGAVAAAPLVLDEGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9Z8</accession>
    <name>C7Z9Z8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_43042</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044898.1">
        <property type="nucleotide sequence ID" value="XM_003044852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9Z8"/>
    <dbReference type="FunCoup" id="C7Z9Z8">
        <property type="interactions" value="232"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z9Z8"/>
    <dbReference type="GeneID" id="9672260"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_43042"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_43042"/>
    <dbReference type="eggNOG" id="KOG2022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005271_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z9Z8"/>
    <dbReference type="OMA" id="CLASIGK"/>
    <dbReference type="OrthoDB" id="2016913at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057942">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF33">
        <property type="entry name" value="IMPORTIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24140">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU39185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1003" mass="109656" checksum="E4586EF519FE1D56" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZA75</accession>
    <name>C7ZA75_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_82001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045342.1">
        <property type="nucleotide sequence ID" value="XM_003045296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZA75"/>
    <dbReference type="GeneID" id="9672120"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82001"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82001"/>
    <dbReference type="eggNOG" id="ENOG502T4GQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075384_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZA75"/>
    <dbReference type="OMA" id="GNICHPL"/>
    <dbReference type="OrthoDB" id="3700556at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU39629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="228" mass="26040" checksum="7B5879A0113B2EA5" modified="2009-10-13" version="1">MAVTRLSVALRPLKAIAWGDLAVASLKVGLVCENYMLVVDDEDLDAATQKLKKNGFREAPWSYGSRDDPTLYTDPKMKQIHRLMAQEYSNLDNHSLKFRFPTDKQAKARVVLLPSSYAHISTTSTTDRFTQKDNIFYPDAPLLLKSFVHTIVKEPEMSQWTSNLEMWAITYLYGDLMLDDGVLDSCDDEEVKAWFNENIQREEGGMDRITCTKRLGKAGYDESLARQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZB01</accession>
    <name>C7ZB01_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_45772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044539.1">
        <property type="nucleotide sequence ID" value="XM_003044493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZB01"/>
    <dbReference type="GeneID" id="9672721"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45772"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45772"/>
    <dbReference type="eggNOG" id="ENOG502QSKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_7_1_1"/>
    <dbReference type="InParanoid" id="C7ZB01"/>
    <dbReference type="OMA" id="RETHAKP"/>
    <dbReference type="OrthoDB" id="184880at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF106">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="36269" checksum="682302FA8AA074EB" modified="2009-10-13" version="1">MLKPHRSAVTDTQSLRSSILNYKWENGRRYHAYQEGSYWAPNDDRQQEAEDLMHEVYRIILNDKLYEAPIGDKPQNVLDLGCGTGIWAIEFADMHPSADVLGVDLSPIQPNFVPPNCRFEVDDISQDWTYPENKFDFVHLRGLTGCIPDWTKFYEGAIKHVKPGGWIEHVELWGTAKSDDDTLRADSPLKTWVEIFTKLGEMTGKTFFWDHKAAESVREGGFINVTERRIKVPIGTWPKDKQLKQWGAWNRQFLLQALEGFSIRGLTEMLGWKYKDAQLYLSDMRKELTNPKLHSYLEVTVVYGQRPEATGEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBK4</accession>
    <name>C7ZBK4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_88457</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698915">
        <property type="protein sequence ID" value="EEU38584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044297.1">
        <property type="nucleotide sequence ID" value="XM_003044251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBK4"/>
    <dbReference type="STRING" id="660122.C7ZBK4"/>
    <dbReference type="GeneID" id="9670620"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88457"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88457"/>
    <dbReference type="eggNOG" id="KOG0653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020695_4_2_1"/>
    <dbReference type="InParanoid" id="C7ZBK4"/>
    <dbReference type="OMA" id="QRMRDHY"/>
    <dbReference type="OrthoDB" id="5003985at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044843">
        <property type="term" value="P:cell cycle G1/S phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20537">
        <property type="entry name" value="CYCLIN_CCNO-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000010">
        <property type="entry name" value="G1/S-specific cyclin Cln1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="83"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
        <location>
            <begin position="183"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="187"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU38584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="295" mass="33572" checksum="2E6DFF278DCCBAF3" modified="2009-10-13" version="1">MGYGLNQQCNTQSRQGRDQIPIESSDHERQTIISSKLSLQTESLYLEEIIQHLEYMQDITLPDDAMIDTQKEITWSMRSCLVDFLVEAHGHFGLAPQALFLSINLVDRYCSRREVRRDHYWLLASAALLIASKYGDKTCGDTKRNHPSIREISGLCCGVFNAATIIQMEMSVLNTLDWVIGHPTIDCFVEMLLSVGEHDDEFRNMVAYICEMALYHRDLISTKPSIIAEASFLLAQEILWQDATSHVGTSDHVRGTLQTLSAHLRHARPVLANKFSTPKRSRVAQRLLNFCHQHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBR1</accession>
    <name>C7ZBR1_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_88498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698915">
        <property type="protein sequence ID" value="EEU38562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044275.1">
        <property type="nucleotide sequence ID" value="XM_003044229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBR1"/>
    <dbReference type="GeneID" id="9670598"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88498"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88498"/>
    <dbReference type="eggNOG" id="ENOG502RPHD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_809139_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZBR1"/>
    <dbReference type="OrthoDB" id="5096715at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="343" mass="38295" checksum="DFDDB549EBE54AEA" modified="2009-10-13" version="1">MDQVVRRVAMLEATPFPEAHHPNVMDCSSRAVRLQDSISNWDQDLKGIQEPDAAFHDELAILRDRSRRRLEQFALYPSQDDISLVQLALLSDGRQIKELELNHAATRAQKQEAYDHGMEVLVGKIIGDLINLFGLPTMQRLAPELFSPNGDQGHIARLSGDFNKLFPPDQPDAAAEELVLQPNGSHTRRAGRLRPMPLPSADSSVAKSGAVKRKQDANIGITRDKRRCLAVVKREPEPEIPRPAFPTSTEPALAVTESLYQHDDRQKAIIRKRGRTLTKKSVEFGVYGHTACVLVYRNPIRHKWVCAMHIPEGQDVPSLDAIVADHLRSEMATESQPSIEAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCV9</accession>
    <name>C7ZCV9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_47960</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698919">
        <property type="protein sequence ID" value="EEU37987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043700.1">
        <property type="nucleotide sequence ID" value="XM_003043654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCV9"/>
    <dbReference type="GeneID" id="9670188"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_47960"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_47960"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_0_1_1"/>
    <dbReference type="InParanoid" id="C7ZCV9"/>
    <dbReference type="OMA" id="TKATFDW"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000024">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000026">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF2">
        <property type="entry name" value="ASPERGILLOPEPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002986998" description="Peptidase A1 domain-containing protein" evidence="7">
        <location>
            <begin position="22"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="8">
        <location>
            <begin position="98"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU37987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="410" mass="43919" checksum="3F801D5FD401B2F8" modified="2009-10-13" version="1">MAPLLVTFLSACLAFGAVVSGCPFRASQDQQFSVEQIKNPGYVANCPKALARAYLKYGAALPEGLAEVMRNTKSHKAKRAGTGTGTVVTTPEDGDVEWLTPIQIGTPGQVLNLDLDTGSSDLWVFTNSTQGASQRTSYNPGKSSTSRKLNGYTFSIQYGDGSSSTGDVYLDKVSAGRLSVNNQAVETASRVDSSFNSEPNLDGLMGLGFSSLNTVRPKQQKTFFDNAIPQLRSPVFTANLKRQRPGTYNFGYIDNSTYTGNIGYVPVDSSRGWWQFTSNGYAVGNDKIGRTSINGIADTGTTLLLLPNTVNQAYYAKVSGSRFDSRMNAYTFRCSTSLPTFSFAVGGVTITIPGTYLNFGAATNDGQTCYGSLQPSDSIGINIFGDIALKAAFVVFDGGQKRIGWARKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZE77</accession>
    <name>C7ZE77_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_87471</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698921">
        <property type="protein sequence ID" value="EEU37685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043398.1">
        <property type="nucleotide sequence ID" value="XM_003043352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZE77"/>
    <dbReference type="GeneID" id="9669283"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87471"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87471"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003864_4_0_1"/>
    <dbReference type="InParanoid" id="C7ZE77"/>
    <dbReference type="OMA" id="HYQRHIR"/>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU37685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="881" mass="99302" checksum="1A9B1D6FE2ADD005" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFK5</accession>
    <name>C7ZFK5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_78355</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698923">
        <property type="protein sequence ID" value="EEU37259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042972.1">
        <property type="nucleotide sequence ID" value="XM_003042926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFK5"/>
    <dbReference type="STRING" id="660122.C7ZFK5"/>
    <dbReference type="GeneID" id="9665018"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78355"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78355"/>
    <dbReference type="eggNOG" id="KOG0660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_627127_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZFK5"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="187"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU37259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="437" mass="48598" checksum="4FB756A27CB8CD54" modified="2009-10-13" version="1">MALPEHSLLFSLIPQNLAAETAIGNLGNKPFVSELPIPRGQNGSIRVVCVRSNPSSASGLEPSFPGHRNGPDQPDRTFRFILNKRTGEVLLEDFSDGQAFRFTGPNAIPFPNPPHPRRLIMDCHHNLEFECLEEPGSWSRWAVFWHQTPPAHPPQRPASTILADDDGSEVYTKYKTTPNSGGDLIRYTDRDWSFASKFGAPRVVVDIGTGQYLAVRKVSYPFKIEARRSMLERIISDSRLSHETPTSIDILMPVQEGDLLWLMEHYQNPTDNFHPLVNTDEMGQLLLGQMLLALDYLESKSVIHHKVCPGNILVNIGLGRGENATFQLSNFEYGGFKGTSLYANDPCFRAPEACGLTDARESPRTDIWGLCATMAYFLDPDFRGFVSSKPLDGLVANAVCLASDMFFALRGMGEWDANNRPSARQKLEEVFGEGVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFN1</accession>
    <name>C7ZFN1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_78425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698923">
        <property type="protein sequence ID" value="EEU37198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042911.1">
        <property type="nucleotide sequence ID" value="XM_003042865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFN1"/>
    <dbReference type="GeneID" id="9665058"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78425"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78425"/>
    <dbReference type="HOGENOM" id="CLU_1704708_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZFN1"/>
    <dbReference type="OrthoDB" id="4526786at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988808" description="Cyanovirin-N domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU37198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="17472" checksum="C73DB0096DCE517F" modified="2009-10-13" version="1">MKPVMFATALATLLTPVVSRCSMDNRWCYWIGTAPFCESTKFKIGEIDETGKVLKAWTKDKDRADLCTTFNHDGDRPSMSCWSGYKRLWCEVDEIHLLCWGKGVLRHFGLLGNFLVRRKDHRGRWLPTIIVFIAVNGKGAALGSFLGQIFILIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFY7</accession>
    <name>C7ZFY7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Manganese lipoxygenase</fullName>
            <ecNumber evidence="3">1.13.11.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_72762</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(9Z,12Z)-octadecadienoate + O2 = (11S)-hydroperoxy-(9Z,12Z)-octadecadienoate</text>
            <dbReference type="Rhea" id="RHEA:18993"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:57467"/>
            <dbReference type="EC" id="1.13.11.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.13.11.45" evidence="3"/>
    <dbReference type="EMBL" id="GG698924">
        <property type="protein sequence ID" value="EEU37060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042773.1">
        <property type="nucleotide sequence ID" value="XM_003042727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFY7"/>
    <dbReference type="GeneID" id="9664889"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_72762"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_72762"/>
    <dbReference type="eggNOG" id="ENOG502QVKD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009802_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZFY7"/>
    <dbReference type="OMA" id="FHNYAYA"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050584">
        <property type="term" value="F:linoleate 11-lipoxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043651">
        <property type="term" value="P:linoleic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034440">
        <property type="term" value="P:lipid oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.245.10">
        <property type="entry name" value="Lipoxygenase-1, Domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000907">
        <property type="entry name" value="LipOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013819">
        <property type="entry name" value="LipOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036226">
        <property type="entry name" value="LipOase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11771">
        <property type="entry name" value="LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00305">
        <property type="entry name" value="Lipoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48484">
        <property type="entry name" value="Lipoxigenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51393">
        <property type="entry name" value="LIPOXYGENASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoxygenase" evidence="9">
        <location>
            <begin position="242"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU37060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="726" mass="82644" checksum="A26E59344D5F76C0" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZH11</accession>
    <name>C7ZH11_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 13">Chitin synthase</fullName>
            <ecNumber evidence="2 13">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">NECHADRAFT_102013</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chitin synthase family. Class III subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 13"/>
    <dbReference type="EMBL" id="GG698927">
        <property type="protein sequence ID" value="EEU36638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042351.1">
        <property type="nucleotide sequence ID" value="XM_003042305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZH11"/>
    <dbReference type="STRING" id="660122.C7ZH11"/>
    <dbReference type="GeneID" id="9669517"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102013"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102013"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004760_0_1_1"/>
    <dbReference type="InParanoid" id="C7ZH11"/>
    <dbReference type="OMA" id="WQRITVA"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF11">
        <property type="entry name" value="CHITIN SYNTHASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 13" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="635"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="680"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="713"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="766"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="801"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="895"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="935"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="16">
        <location>
            <begin position="197"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="839"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEU36638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="970" mass="109873" checksum="28BDFBB09810DE83" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZH14</accession>
    <name>C7ZH14_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_51830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698927">
        <property type="protein sequence ID" value="EEU36732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042445.1">
        <property type="nucleotide sequence ID" value="XM_003042399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZH14"/>
    <dbReference type="GeneID" id="9669520"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51830"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51830"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006909_5_3_1"/>
    <dbReference type="InParanoid" id="C7ZH14"/>
    <dbReference type="OMA" id="GHYNIPW"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU36732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="54717" checksum="CA38D0C29B6CA196" modified="2009-10-13" version="1">MPSQIRRVAVIGAGPAGAIATDALVKEGAFDTIRVFDRRAGVGGTWIHTPHLPAGIPSLKKVLAGDADTAVPIPENLPAVTTVSEAVNSHQYRFSDTAIHENLHSNITPAIMSFTQEPFPDKLSQRSLDEYGPNAPFRHHTTIREWIEGIFSRGGHEKLLELDTTVERAVKENGEWVLTLRKVVNGRNYWWRETFDALVVASGHYNVPWFPEVTGLIEFDKRFPGVVQHSKHFREGPKYTGKRVIVVGASVSSHEIIHEILDFTEGPVYASIRGDPIPAFGWEPFTHPKIAIKPAISRLDPETGKVHFTDGTQLDKVDHIIYGTGYTFSFPFLPEVQSRVKNAYRRLPGVYQHTWNIEDPTLTFVGMLGGGFTFRAYEWQAVAVARTLSGRAKPLPSVPEQLEWERKRVAEKKGGKDYYSIAPDYDKYLEFLRDIAGEPAQGTNGRTLPPFDPKWLEIWAGMVAPKLEGWRRKRKLAEEKQALRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHB5</accession>
    <name>C7ZHB5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_86550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698927">
        <property type="protein sequence ID" value="EEU36723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042436.1">
        <property type="nucleotide sequence ID" value="XM_003042390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHB5"/>
    <dbReference type="GeneID" id="9669515"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86550"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86550"/>
    <dbReference type="eggNOG" id="ENOG502RB81">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039268_2_1_1"/>
    <dbReference type="InParanoid" id="C7ZHB5"/>
    <dbReference type="OMA" id="LNFCDTG"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23132">
        <property type="entry name" value="D-ALANINE--D-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23132:SF23">
        <property type="entry name" value="D-ALANINE--D-ALANINE LIGASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="4">
        <location>
            <begin position="103"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU36723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="359" mass="40124" checksum="615E6CBAED5474E0" modified="2009-10-13" version="1">MRTREWPLTVAFIYDRKVEHIAHAESPDEYSDLADDVTIGGITEALERLGHRVVHAPGLKALIKDIAANKHKNWDVVFNYSKGSHGTARESQVPAILEEYQIPFTFSDAEIRTSPYVVVPKFDDDPLDYSELKKLSYPLFVKPTSCPQCNGITCANKILKPKDLEHEVDQLRSQFKDQEILIENFLGGREFTLAIAGTGEDAHVVGIAELIWNPHTLRAKDMIPVDFSIALARMARSVSKGFSLEDVPLSDPLWDELADLSLKAYTALGCRDGGRVDIRLTSEEQGSAPCVIEVPSSCQAVSLLSTDAIQVDPIFGMRPDRSRYAFIAKSNGVEYPEMIQDFLDIAIQTYEQAERNLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHF7</accession>
    <name>C7ZHF7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GPN-loop GTPase</fullName>
            <ecNumber evidence="7">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_61599</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="7"/>
    <dbReference type="EMBL" id="GG698928">
        <property type="protein sequence ID" value="EEU36462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042175.1">
        <property type="nucleotide sequence ID" value="XM_003042129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHF7"/>
    <dbReference type="FunCoup" id="C7ZHF7">
        <property type="interactions" value="866"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZHF7"/>
    <dbReference type="GeneID" id="9669352"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_61599"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_61599"/>
    <dbReference type="eggNOG" id="KOG1532">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037460_1_2_1"/>
    <dbReference type="InParanoid" id="C7ZHF7"/>
    <dbReference type="OMA" id="MIIVFNK"/>
    <dbReference type="OrthoDB" id="243313at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17870">
        <property type="entry name" value="GPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000579">
        <property type="entry name" value="GPN-loop GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="321"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU36462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="386" mass="42700" checksum="86C37E8739E33829" modified="2009-10-13" version="1">MASSSTADAPAASSPPVAIVCVGMAGSGKTTFMRRINAHLHQKETPPYVINLDPAVLSVPFESNIDIRDSVNYEEVMKQYNLGPNGGILTSLNLFATKVDQIVNLLEKRAQPDPEKPDRKPIDRILVDTPGQIEVFVWSASGTILLESLASSFPTVIAYVIDTPRTASTSTFMSNMLYACSILYKTKLPMILVFNKTDVKDAEFAKEWMTDFEAFQEALRRDEDSDALGGVEGGGHGGSGYMGSLLNSMSLMLEEFYAHLSVVGVSSRLGTGVDEFFEAVEEKKQEFLRDYLPELERRRAERDEQKKAAREKELDKMMQGMTVGAQPAPKKDDDDDVDVPSDDDDTDSDDEAKKESLQERYQAAMGDNEDSIMADASFAKYLHTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHH2</accession>
    <name>C7ZHH2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dolichol-phosphate mannosyltransferase subunit 1</fullName>
            <ecNumber evidence="13">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NECHADRAFT_94136</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP</text>
            <dbReference type="Rhea" id="RHEA:21184"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 13">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="13"/>
    <dbReference type="EMBL" id="GG698928">
        <property type="protein sequence ID" value="EEU36467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042180.1">
        <property type="nucleotide sequence ID" value="XM_003042134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHH2"/>
    <dbReference type="FunCoup" id="C7ZHH2">
        <property type="interactions" value="883"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZHH2"/>
    <dbReference type="GeneID" id="9669361"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94136"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94136"/>
    <dbReference type="eggNOG" id="KOG2978">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_13_3_1"/>
    <dbReference type="InParanoid" id="C7ZHH2"/>
    <dbReference type="OMA" id="KCFRREV"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006720">
        <property type="term" value="P:isoprenoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000036">
        <property type="entry name" value="Dolichol-phosphate mannosyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="14">
        <location>
            <begin position="9"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU36467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="240" mass="26837" checksum="0E371512561BF51B" modified="2009-10-13" version="1">MASKANKYSVILPTYNERKNLPIMTWLLNRMFTENNLEWELIIVDDGSPDGTQEVALQLVEAYSPHVVLKTRTGKLGLGTAYVHGLQFVTGNFVVIMDADFSHHPKFIPQMVALQEKGNYDIVTGTRYAGDGGVYGWDLKRKFVSRGANLFADTVLRPGVSDLTGSFRLYKRSVLEKVISSTESKGYSFQMEMMVRAKAMGCTVAEVPISFVDRLYGESKLGGDEIVQYAQGVFNLWLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZI01</accession>
    <name>C7ZI01_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatidylethanolamine-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_72804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698929">
        <property type="protein sequence ID" value="EEU36305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042018.1">
        <property type="nucleotide sequence ID" value="XM_003041972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZI01"/>
    <dbReference type="FunCoup" id="C7ZI01">
        <property type="interactions" value="1392"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZI01"/>
    <dbReference type="GeneID" id="9674419"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_72804"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_72804"/>
    <dbReference type="eggNOG" id="KOG3346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043994_3_1_1"/>
    <dbReference type="InParanoid" id="C7ZI01"/>
    <dbReference type="OMA" id="EFKHWVV"/>
    <dbReference type="OrthoDB" id="2506647at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030162">
        <property type="term" value="P:regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046578">
        <property type="term" value="P:regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF85">
        <property type="entry name" value="INHIBITOR (TFS1), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU36305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="21781" checksum="342819967D59EBF3" modified="2009-10-13" version="1">MPLKEHAKALSASLAEAKLVPGVAASLIPEDFKPTTKLDVAFDGNALKLGNLFRASQCRLAPSIRFSKEPDSPSDATYMLLLVDPDAPTPDDPKFAFWRHWVLPGLMPLSGDEGMVAQVQPALTEYLGPGPKDDSKPHRYLFLLFRQPTTLDLTKEDVGGEEFVQRRSFDPAKFVEKHNLHLVGLNWMLGAGDGWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZI38</accession>
    <name>C7ZI38_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_64545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698929">
        <property type="protein sequence ID" value="EEU36399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042112.1">
        <property type="nucleotide sequence ID" value="XM_003042066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZI38"/>
    <dbReference type="GeneID" id="9669040"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_64545"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_64545"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_5_1"/>
    <dbReference type="InParanoid" id="C7ZI38"/>
    <dbReference type="OMA" id="EAYGQHW"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF274">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU36399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="26594" checksum="30A2FAFBC6B0FA89" modified="2009-10-13" version="1">MVRVFITGSSDGIGQAAAKLLAEQGHQVTLHARNADRAASAQAAIPKAKAVLIGDLSSIAETKKLAQEANAAGPFDAIIHNAGIGYGATSSRQITPDKISAVFAVNTLAPYILTCLMDKPTSRLLFMSSDSHYSGDETLRNATQSHSYGDSKLHDVMLGKAFARRWGDIQVLSMHPGWVRTKMGGRAAPGGTDRPAVALADWAAGEGVLAKIKSGAFVSTSRESTSHPGADVVSKQEELLDICKQVSGVSVPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZIZ8</accession>
    <name>C7ZIZ8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_49769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698932">
        <property type="protein sequence ID" value="EEU35988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041701.1">
        <property type="nucleotide sequence ID" value="XM_003041655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZIZ8"/>
    <dbReference type="GeneID" id="9674042"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_49769"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_49769"/>
    <dbReference type="eggNOG" id="ENOG502SHAD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064039_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZIZ8"/>
    <dbReference type="OMA" id="WHLQFLI"/>
    <dbReference type="OrthoDB" id="2135488at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052358">
        <property type="entry name" value="Aro_Compnd_Degr_Hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35563">
        <property type="entry name" value="BARREL METAL-DEPENDENT HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35563:SF2">
        <property type="entry name" value="BARREL METAL-DEPENDENT HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="20"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="316" mass="36081" checksum="5BE41A8442567627" modified="2009-10-13" version="1">MAPEALVETNNADLFPRGGWDTHHHIFEPQAFPYSPTRHLTPPAATIKAFENFRARLGITNSVLTHGLSYGDDCTSLKAFVTKLGRQSTSGVGVIEPDKTTDDEIRDLQKAGVRGLRVNLYPNGAMEDVELQKEKLRAYLQRIINLSLDWSLTMTTIRTEFWDELEPFVRSEVGPTGRPLITDHFGLLKAPSMLPPEYRNDPTKQPGFAAIMRLVRDGLLFVKLSAPYRVSELSPRYDDLKFLVRAFVDANKHQALWGSDWPHTPRMRVRSHEEAMKETPFLEVDDEAWLRSLRGWLSDEEWDLLMVQNPQHIFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJV4</accession>
    <name>C7ZJV4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_87947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698936">
        <property type="protein sequence ID" value="EEU35697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041410.1">
        <property type="nucleotide sequence ID" value="XM_003041364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJV4"/>
    <dbReference type="GeneID" id="9676165"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87947"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87947"/>
    <dbReference type="eggNOG" id="ENOG502SS3M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097601_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZJV4"/>
    <dbReference type="OMA" id="MDTHYAS"/>
    <dbReference type="OrthoDB" id="512662at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="91"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="238" mass="27027" checksum="46E34F23C6658AB8" modified="2009-10-13" version="1">MAPYLQAHLRRSRFPGQVHPGPSVIVSAFSMAKTVRPTVHMRPLSLGPGWGTLEPALQRWQEARVRDHTVRGIGMEAVAEGKIPSSVGVCFLFPPQPQRRWLNPLWWPAYLRVLWDQYWAKPKEPFTDEERIGIMMDGHYASAKKIKSRYPPNSLYYLEIAAVKPDTQGMGVGGAIMSWVVDRLGKSPCFLECTNERNIAFYEKYGFKLLEEKTLFHGANQSSATLFYMVRDKASLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKH4</accession>
    <name>C7ZKH4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_86156</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="GG698940">
        <property type="protein sequence ID" value="EEU35405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041118.1">
        <property type="nucleotide sequence ID" value="XM_003041072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKH4"/>
    <dbReference type="ESTHER" id="nech7-c7zkh4">
        <property type="family name" value="Carb_B_Bacteria"/>
    </dbReference>
    <dbReference type="GeneID" id="9675826"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86156"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86156"/>
    <dbReference type="eggNOG" id="KOG1516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_16_4_1"/>
    <dbReference type="InParanoid" id="C7ZKH4"/>
    <dbReference type="OMA" id="PAEPWIF"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="17"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU35405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="552" mass="59569" checksum="F71F9285E5BA80B7" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKW0</accession>
    <name>C7ZKW0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Beta-coat protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NECHADRAFT_69963</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1 10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasmic vesicle</location>
            <location evidence="10">COPI-coated vesicle membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698941">
        <property type="protein sequence ID" value="EEU35399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041112.1">
        <property type="nucleotide sequence ID" value="XM_003041066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKW0"/>
    <dbReference type="FunCoup" id="C7ZKW0">
        <property type="interactions" value="1278"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZKW0"/>
    <dbReference type="GeneID" id="9675534"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_69963"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_69963"/>
    <dbReference type="eggNOG" id="KOG1058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006949_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZKW0"/>
    <dbReference type="OMA" id="IYKNFDW"/>
    <dbReference type="OrthoDB" id="10261439at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000260">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011710">
        <property type="entry name" value="Coatomer_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016460">
        <property type="entry name" value="COPB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029446">
        <property type="entry name" value="COPB1_appendage_platform_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635:SF0">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07718">
        <property type="entry name" value="Coatamer_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14806">
        <property type="entry name" value="Coatomer_b_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005727">
        <property type="entry name" value="Coatomer_beta_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="12">
        <location>
            <begin position="25"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit C-terminal" evidence="13">
        <location>
            <begin position="679"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit appendage platform" evidence="14">
        <location>
            <begin position="820"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="496"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU35399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="957" mass="106540" checksum="982E07EC4DCCC77B" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZL38</accession>
    <name>C7ZL38_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_73077</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698943">
        <property type="protein sequence ID" value="EEU35222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040935.1">
        <property type="nucleotide sequence ID" value="XM_003040889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZL38"/>
    <dbReference type="GeneID" id="9675366"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_73077"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_73077"/>
    <dbReference type="eggNOG" id="ENOG502SRJN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055491_1_1_1"/>
    <dbReference type="InParanoid" id="C7ZL38"/>
    <dbReference type="OMA" id="HIWCKEA"/>
    <dbReference type="OrthoDB" id="5290969at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF3">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="6">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU35222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="145" mass="15737" checksum="A88835EBE9CB21F6" modified="2009-10-13" version="1">MNVSCQCGAVQMTASRPEPIDVYCCHCLECQKQSASAFGTSAIFPADSMWPLPAEVQSQLGLWTRPADSGNTVECYFCKTCGVRVIHRSILPDGNPKPYLSIKGGLVEGLKWDAPKHIFTRTARVPFPEGSDPGSPTSHPVVKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLQ7</accession>
    <name>C7ZLQ7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_82472</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698946">
        <property type="protein sequence ID" value="EEU35072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040785.1">
        <property type="nucleotide sequence ID" value="XM_003040739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLQ7"/>
    <dbReference type="GeneID" id="9679219"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82472"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82472"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_6_2_1"/>
    <dbReference type="InParanoid" id="C7ZLQ7"/>
    <dbReference type="OMA" id="SEFSNCH"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="155"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU35072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="335" mass="37355" checksum="66E9978F17D05D39" modified="2009-10-13" version="1">MATEIFPVIDLSTGDDWPQALGPKIVEACQVWGFMILTGHGIPQQKIDRMFDLHKEFCAQPLEVKSECRVDERQIGYDVKNSKIGVNECMVFGGTRGDVAQGKNIPSWWDAKKRADVEDFKSQAHGLGLKLLEVFATHFSLPADYFSAAHNDERGPGSVLRMLHYPTMDERPDKNFPRLYSHTDWGSVTFVWPQGGGLEVETPSKKWMPVPLIPGSIVVNIGDALSLWSGKTLKSTLHKISFDNLPIDQDHAKLEIIKRDHEGKLVKDDGSIELTAGEYHQVRHYMSEKEDAKNNWVGKTKGSSKFDPRVIHAVESLGIANGSGLVNFSPIAVNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLY8</accession>
    <name>C7ZLY8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">(S)-ureidoglycine aminohydrolase cupin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_37399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698948">
        <property type="protein sequence ID" value="EEU34978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040691.1">
        <property type="nucleotide sequence ID" value="XM_003040645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLY8"/>
    <dbReference type="GeneID" id="9679124"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_37399"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_37399"/>
    <dbReference type="HOGENOM" id="CLU_141740_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZLY8"/>
    <dbReference type="OMA" id="MLYKPAA"/>
    <dbReference type="OrthoDB" id="4985585at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010424">
        <property type="entry name" value="EutQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008579">
        <property type="entry name" value="UGlyAH_Cupin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36169:SF1">
        <property type="entry name" value="ACETATE KINASE EUTQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36169">
        <property type="entry name" value="ETHANOLAMINE UTILIZATION PROTEIN EUTQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05899">
        <property type="entry name" value="Cupin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="(S)-ureidoglycine aminohydrolase cupin" evidence="1">
        <location>
            <begin position="46"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="121" mass="12963" checksum="1A0F8A825D6F10ED" modified="2009-10-13" version="1">MSGSFLTPIVHFPNAQDSFQCPQVAGTKNAFLGDIYGTDASSVDPLSCGFFRMTAGESLTGKYPYNETLVVLDGVFEMVDGAGSKSVAKKGDVYFFPAGSMVTFSTSQEGLAFYTVQRARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZM10</accession>
    <name>C7ZM10_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_123123</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698948">
        <property type="protein sequence ID" value="EEU34994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_003040707.1">
        <property type="nucleotide sequence ID" value="XM_003040661.1"/>
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    <dbReference type="STRING" id="660122.C7ZM10"/>
    <dbReference type="GeneID" id="9679130"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_123123"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_123123"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_31_1_1"/>
    <dbReference type="InParanoid" id="C7ZM10"/>
    <dbReference type="OMA" id="PNNRCIW"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:polyketide biosynthetic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Polyketide synthase Pks12"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF49">
        <property type="entry name" value="SYNTHASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="20"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="918"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="9">
        <location>
            <begin position="918"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="9">
        <location>
            <begin position="1063"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="9">
        <location>
            <position position="950"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="9">
        <location>
            <position position="1124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU34994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2513" mass="275090" checksum="9B49342358F5B843" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZN57</accession>
    <name>C7ZN57_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_88837</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698963">
        <property type="protein sequence ID" value="EEU34540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040253.1">
        <property type="nucleotide sequence ID" value="XM_003040207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZN57"/>
    <dbReference type="GeneID" id="9678075"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88837"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88837"/>
    <dbReference type="HOGENOM" id="CLU_483190_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZN57"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="343"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="494"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="524"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="447"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU34540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="564" mass="63306" checksum="1B7392298C703E59" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNI4</accession>
    <name>C7ZNI4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_87053</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698968">
        <property type="protein sequence ID" value="EEU34429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040142.1">
        <property type="nucleotide sequence ID" value="XM_003040096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNI4"/>
    <dbReference type="GeneID" id="9677976"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87053"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87053"/>
    <dbReference type="eggNOG" id="KOG0759">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1695979_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZNI4"/>
    <dbReference type="OMA" id="RMCADGS"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU34429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="155" mass="16904" checksum="3419AB957E189211" modified="2009-10-13" version="1">MSLTNNAVKVRLQSTLMPAQASIIGMTTHVIATEGYFGLYSGLSAALLRQFTYSTLRFGVYEDLKSRLPHHEDKTAHSPLALISLSALSGFLGGVAGSPADIVNSRHLVASFTAGVIATTMFKGWVPSFLRLGPQTVLTLLILEQHKRLYNKMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNV1</accession>
    <name>C7ZNV1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kelch repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_50289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039779.1">
        <property type="nucleotide sequence ID" value="XM_003039733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNV1"/>
    <dbReference type="STRING" id="660122.C7ZNV1"/>
    <dbReference type="GeneID" id="9677908"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_50289"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_50289"/>
    <dbReference type="eggNOG" id="KOG1072">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004253_10_0_1"/>
    <dbReference type="InParanoid" id="C7ZNV1"/>
    <dbReference type="OMA" id="FPYPVHH"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002989002" description="Kelch repeat-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="36517" checksum="E64ED9596B2D9093" modified="2009-10-13" version="1">MRLALTAISTLWAATLASPTPHAQGTWEILSPIPIAPRQEHSVAALSENTLAIVGGIIPNPDGEGINTTSIVQLYDIPTDTWRSVAPAPIQVNHPNVVAADGKIYLLGGLSVASDGAWRAFPDSWVYYAERDEWLPLDPIPDGQERGSAAMGVYGSTIYMAGGMRTLVPGPGGEQDTVDFVSAFDTVSSKWIRLPKPARKIPEGRDHAGVAVVGNKFYVLGGRLRGQHNVKDTVFILDPKNLHKGWTTSKSRMPTPRGGVVSGTIGCEVYIMGGEGNTAAGAEGIFNDVEVFDTKAEAWRKLDAMRLPRHGGSAVAVNDGIYLPGGGTRLGGSPVDVLDVYWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPH0</accession>
    <name>C7ZPH0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_49987</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040059.1">
        <property type="nucleotide sequence ID" value="XM_003040013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZPH0"/>
    <dbReference type="FunCoup" id="C7ZPH0">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZPH0"/>
    <dbReference type="GeneID" id="9677791"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_49987"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_49987"/>
    <dbReference type="eggNOG" id="ENOG502S535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061619_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZPH0"/>
    <dbReference type="OMA" id="DCPTFTT"/>
    <dbReference type="OrthoDB" id="5394411at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024624">
        <property type="entry name" value="Pyridox_Oxase_Alr4036_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243">
        <property type="entry name" value="AGL049CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE ALR4036 FAMILY FMN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12766">
        <property type="entry name" value="Pyridox_oxase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding" evidence="2">
        <location>
            <begin position="10"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU34346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="256" mass="28517" checksum="CB87466B7B669D1F" modified="2009-10-13" version="1">MSSSRPTQAAPWRSAFLTHVNELDSPTFMLSTLHHDSSTTVTPRSRTVVFRGLWAELPANPKNKAPLNPSVYESDLLTITTDARMEKIPELSPDGSSPAQSGGGGPVEAVFWAVPSRTQWRLRGRAYLLGPDINDPSGAQVREVLEKHMRRKNSDDSSSWDWAKEVTAHFGNMSPMMRGSFRNPAPGTPKTEKPGPGLGLGQKVEDLDDEIARKNFRVVVIVPEEVDRVDLSDPEEGKRWNYRLAGDSWEETELWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQ13</accession>
    <name>C7ZQ13_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_88818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698978">
        <property type="protein sequence ID" value="EEU33892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039605.1">
        <property type="nucleotide sequence ID" value="XM_003039559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQ13"/>
    <dbReference type="GeneID" id="9667124"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88818"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88818"/>
    <dbReference type="HOGENOM" id="CLU_674536_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZQ13"/>
    <dbReference type="OrthoDB" id="10460875at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU33892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="408" mass="45048" checksum="3AC48A4E2D20B93A" modified="2009-10-13" version="1">MAEHFGSNGFDFGGGGFEFRDSSFGGSGFGHWSFPSSSPILNNHSTFDFFRDCNPYSGSSLDRPKPSAYSSVPKGPGNHEYDFFVSNLREGDASSSSEPPMAPTSDTTFMPRTFTTQRGSSNDSPGYNAPLNFIDQSWVTWSASGSGLPKLDIQLKTPRWAKAGRLEYDHSFTFDPHADLTFPCTTKRLVYKSPLERVEFGLGSYGDLPTWTTTQDAWIAFDVTGSRSKTIFSLASVADLVWMVLELQLTITGIATQRPRTCFVEHHHKVDGCGEGKVKVQHRTKSSDERGAHRDASMLPNWLLDPDRSTVLTACGPHEVAIEPRFDGQRHGALSHLLLKVLEGVGRKYRSTASKIINHYPSVTRPSSIYVRKRAFVNLLVTLPCTYIISTDMPGIQDIILAPLPLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQS1</accession>
    <name>C7ZQS1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_19942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699009">
        <property type="protein sequence ID" value="EEU33635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039348.1">
        <property type="nucleotide sequence ID" value="XM_003039302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQS1"/>
    <dbReference type="GeneID" id="9666868"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_19942"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_19942"/>
    <dbReference type="HOGENOM" id="CLU_184135_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZQS1"/>
    <dbReference type="OMA" id="HRARHKE"/>
    <dbReference type="OrthoDB" id="4505928at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42070">
        <property type="entry name" value="FILAMENT ASSOCIATED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42070:SF1">
        <property type="entry name" value="FILAMENT ASSOCIATED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU33635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="64" mass="7476" checksum="2442581B4D389FBF" modified="2009-10-13" version="1" fragment="single">ENKRRYRARRKEYVSDLERRLAEAREQGVKATTEVQSAARKVVEENGQLRDLLRLAGFADEDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>C7YH63</accession>
    <name>C7YH63_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ABC transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_90112</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054290.1">
        <property type="nucleotide sequence ID" value="XM_003054244.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9664446"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90112"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90112"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_17_0_1"/>
    <dbReference type="InParanoid" id="C7YH63"/>
    <dbReference type="OMA" id="HIRSMGN"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000057">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="748"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="796"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="866"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="896"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="977"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1015"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="44"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="385"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="752"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1096"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="699"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1057"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="587"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="714"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU48577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1338" mass="144076" checksum="E6E402AF92DA5F0E" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHR6</accession>
    <name>C7YHR6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_75061</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054399.1">
        <property type="nucleotide sequence ID" value="XM_003054353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YHR6"/>
    <dbReference type="GeneID" id="9674619"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75061"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75061"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019268_1_0_1"/>
    <dbReference type="InParanoid" id="C7YHR6"/>
    <dbReference type="OMA" id="GREVWWH"/>
    <dbReference type="OrthoDB" id="10006946at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF28">
        <property type="entry name" value="FRP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="275"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU48686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="561" mass="62705" checksum="26AEB36CF8E692E5" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHU2</accession>
    <name>C7YHU2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_31392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <dbReference type="InParanoid" id="C7YJJ9"/>
    <dbReference type="OMA" id="QDANIRS"/>
    <dbReference type="OrthoDB" id="5106806at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002986265" evidence="2">
        <location>
            <begin position="19"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU48287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="662" mass="64552" checksum="A91E26D1DD09A595" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJL9</accession>
    <name>C7YJL9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_103286</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Mediates the transfer of lipids between membranes at organelle contact sites. May play a role in mitochondrial lipid homeostasis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the VPS13 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EEU49000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054713.1">
        <property type="nucleotide sequence ID" value="XM_003054667.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="C7YJL9">
        <property type="interactions" value="760"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YJL9"/>
    <dbReference type="GeneID" id="9676634"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_103286"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_103286"/>
    <dbReference type="eggNOG" id="KOG1809">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000135_0_0_1"/>
    <dbReference type="InParanoid" id="C7YJL9"/>
    <dbReference type="OMA" id="SGWRPIR"/>
    <dbReference type="OrthoDB" id="428159at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056748">
        <property type="entry name" value="VPS13-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056747">
        <property type="entry name" value="VPS13-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017148">
        <property type="entry name" value="VPS13_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25033">
        <property type="entry name" value="VPS13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037235">
        <property type="entry name" value="VPS13_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3 4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="VPS13-like middle region" evidence="8">
        <location>
            <begin position="1098"/>
            <end position="1902"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding" evidence="9">
        <location>
            <begin position="1969"/>
            <end position="2544"/>
        </location>
    </feature>
    <feature type="domain" description="Intermembrane lipid transfer protein VPS13-like C-terminal" evidence="10">
        <location>
            <begin position="3066"/>
            <end position="3169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="833"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1561"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1730"/>
            <end position="1800"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="415"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="861"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1576"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
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            <end position="1599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1735"/>
            <end position="1751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1757"/>
            <end position="1768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU49000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="3196" mass="359504" checksum="2CDE8BC570887C02" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJM8</accession>
    <name>C7YJM8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_75734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054015.1">
        <property type="nucleotide sequence ID" value="XM_003053969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJM8"/>
    <dbReference type="GeneID" id="9676638"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75734"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75734"/>
    <dbReference type="eggNOG" id="ENOG502SSBS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023254_1_0_1"/>
    <dbReference type="InParanoid" id="C7YJM8"/>
    <dbReference type="OMA" id="MWIDVIH"/>
    <dbReference type="OrthoDB" id="4158087at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF9">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU48302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="521" mass="59954" checksum="C1ADFC215124C46E" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7YK22</accession>
    <name>C7YK22_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit D</fullName>
            <shortName evidence="5">eIF3d</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_89901</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit D family.</text>
    </comment>
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        <property type="protein sequence ID" value="EEU48373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054086.1">
        <property type="nucleotide sequence ID" value="XM_003054040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YK22"/>
    <dbReference type="STRING" id="660122.C7YK22"/>
    <dbReference type="GeneID" id="9676711"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89901"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89901"/>
    <dbReference type="eggNOG" id="KOG2479">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024521_2_0_1"/>
    <dbReference type="InParanoid" id="C7YK22"/>
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    <dbReference type="OrthoDB" id="16538at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098808">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002191">
        <property type="term" value="P:cap-dependent translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03003">
        <property type="entry name" value="eIF3d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007783">
        <property type="entry name" value="eIF3d"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05091">
        <property type="entry name" value="eIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016281">
        <property type="entry name" value="EIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="114"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA gate" evidence="5">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU48373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="577" mass="63804" checksum="41B44E04C97868DE" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7YK83</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_103068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053411.1">
        <property type="nucleotide sequence ID" value="XM_003053365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YK83"/>
    <dbReference type="GeneID" id="9676743"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_103068"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_103068"/>
    <dbReference type="eggNOG" id="ENOG502QPI7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010671_2_1_1"/>
    <dbReference type="InParanoid" id="C7YK83"/>
    <dbReference type="OMA" id="DRWSPHM"/>
    <dbReference type="OrthoDB" id="20669at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991:SF12">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="627"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU47698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="807" mass="88701" checksum="CCD06CC4E6586517" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7YKQ9</accession>
    <name>C7YKQ9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_90031</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053494.1">
        <property type="nucleotide sequence ID" value="XM_003053448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YKQ9"/>
    <dbReference type="STRING" id="660122.C7YKQ9"/>
    <dbReference type="GeneID" id="9676826"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90031"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90031"/>
    <dbReference type="eggNOG" id="KOG0605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_19_2_1"/>
    <dbReference type="InParanoid" id="C7YKQ9"/>
    <dbReference type="OMA" id="LRWIHRD"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF400">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="272"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="12">
        <location>
            <begin position="615"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="106"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU47781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="780" mass="89359" checksum="2AE778760D957EE6" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7YKU1</accession>
    <name>C7YKU1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_35890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052390.1">
        <property type="nucleotide sequence ID" value="XM_003052344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YKU1"/>
    <dbReference type="GeneID" id="9670919"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_35890"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_35890"/>
    <dbReference type="eggNOG" id="ENOG502QSKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_0_0_1"/>
    <dbReference type="InParanoid" id="C7YKU1"/>
    <dbReference type="OMA" id="FILFMAH"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU46677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="34651" checksum="4B2D0C4EC18AAA49" modified="2009-10-13" version="1" fragment="single">DSIVDADNNSSTASVTSSILEYRTIHGRTYNSEQGNAQYWSLPPSHHILTLGLGNKLHLAPLEKDKVHRAIDIGCGTGIWAIDFADDYPNAEITGTDISPIQPSWVPPNLQFEIEDCTREWTFKSNSTDYVHMRWLMGSIRDWDFLSSEAFRVCKPGGWVESHEASSNIDSDDNTVDGNSAMGQWGKLFIEGSKKIGTSFTVVEDGTQRKALEKAGFINIQEFDFKNPIGGWSSDPTEKEMGPYTKYGLETDTEGFVLFMAHTLGWSRDEIQLYIDQFRRELRSEKHHGYFKQKVVWGQKPDTSSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C7YKY5</accession>
    <name>C7YKY5_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_77338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052414.1">
        <property type="nucleotide sequence ID" value="XM_003052368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YKY5"/>
    <dbReference type="GeneID" id="9670946"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77338"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77338"/>
    <dbReference type="HOGENOM" id="CLU_2250788_0_0_1"/>
    <dbReference type="InParanoid" id="C7YKY5"/>
    <dbReference type="OrthoDB" id="5052928at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU46701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="104" mass="11939" checksum="F5658E2DFB04E758" modified="2009-10-13" version="1">MASVWPGYFTTHKIPIEWIYDQKVFTDALTKIYGPNYMLTWGPALMTVDTTQREPEKLKQKLVDEDIIRDPSCKCTNCQRMIQELKPKEPEVTGEASGSNQGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLA1</accession>
    <name>C7YLA1_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_77457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052465.1">
        <property type="nucleotide sequence ID" value="XM_003052419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YLA1"/>
    <dbReference type="GeneID" id="9663627"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77457"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77457"/>
    <dbReference type="HOGENOM" id="CLU_869025_0_0_1"/>
    <dbReference type="InParanoid" id="C7YLA1"/>
    <dbReference type="OrthoDB" id="5102543at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU46752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="320" mass="36017" checksum="54C8B58528815E1A" modified="2009-10-13" version="1">MASTPTQTQHDPKKPSASSDSKSKAKFAARNLRIDTHLPYKDDDPSTCTLARGSPVTAIPPLPPKSEKRKKGPSGVPMDSLLAPKSVFTPPLPFRRDEPGWRPPRFDRGSRPHCPEKLYLSDIHRWRYIDKYGRRVYATRNTALLSPQAIPADVPLIKPTARAPQAKVSEEKVPETAIPPTQVSPMKASPSMVSTEPESVLSRMPFTDPSSPISSASSDSLPEIMTRQRRKRREEMKQATHSEEDFSEEDFRQIYQANYPRLRVTETPRNQEAVFWDGDGNLTYSVYCHVKGWRLADGYNSSRGISTLLKIWGLSELDCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLG3</accession>
    <name>C7YLG3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_77521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052494.1">
        <property type="nucleotide sequence ID" value="XM_003052448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YLG3"/>
    <dbReference type="STRING" id="660122.C7YLG3"/>
    <dbReference type="GeneID" id="9663660"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77521"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77521"/>
    <dbReference type="eggNOG" id="ENOG502RXKN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017444_1_0_1"/>
    <dbReference type="InParanoid" id="C7YLG3"/>
    <dbReference type="OMA" id="PAHREFQ"/>
    <dbReference type="OrthoDB" id="1911848at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF3">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="243"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU46781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="565" mass="63270" checksum="C345CAADF4026D7D" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLI2</accession>
    <name>C7YLI2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cation-transporting P-type ATPase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_103674</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052981.1">
        <property type="nucleotide sequence ID" value="XM_003052935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YLI2"/>
    <dbReference type="GeneID" id="9663747"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_103674"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_103674"/>
    <dbReference type="eggNOG" id="KOG0203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_4_1_1"/>
    <dbReference type="InParanoid" id="C7YLI2"/>
    <dbReference type="OMA" id="QQPPIFN"/>
    <dbReference type="OrthoDB" id="158672at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000114">
        <property type="entry name" value="H /K ATPase alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF21">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="790"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="819"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="860"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="923"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="961"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="992"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="10">
        <location>
            <begin position="28"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU47268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1031" mass="114171" checksum="5C1B5B5612E161FC" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLJ4</accession>
    <name>C7YLJ4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bud22 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_36200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052505.1">
        <property type="nucleotide sequence ID" value="XM_003052459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YLJ4"/>
    <dbReference type="STRING" id="660122.C7YLJ4"/>
    <dbReference type="GeneID" id="9663755"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_36200"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_36200"/>
    <dbReference type="eggNOG" id="ENOG502S6Z4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029647_0_0_1"/>
    <dbReference type="InParanoid" id="C7YLJ4"/>
    <dbReference type="OMA" id="ALWEKKF"/>
    <dbReference type="OrthoDB" id="3364872at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037393">
        <property type="entry name" value="Bud22/SRFB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015158">
        <property type="entry name" value="Bud22_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325:SF1">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09073">
        <property type="entry name" value="BUD22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bud22" evidence="3">
        <location>
            <begin position="16"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="357"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU46792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="454" mass="50561" checksum="8D20C62122DB468E" modified="2009-10-13" version="1">MPKRKRGEPSLEDKLEKQCNEVFRALKSAKGFERQRLSKRLREDGIGPDKKERLEREVTVLKSLDLHQTARAHMYSSLLKVKTLAASPDLPEEIRAGVPKPELSPDEQAALHNVTSGLYNREPVKQAVDRAVTAVCQALNVPLPEKAKRSRKSKREEKEDQPSDRIEKATKTEEEAPEDDVLVSVEEEEDAYDEESEFEGFSDVDAAAQDIEEMDSGDEADEEKELSKYDDLLGGSSDEDEDFDDERFAQFRGKEKVNLDDISVSGSDAEPGLDSDSDSEPEARKQVSVSLSPSPPPAKKKKKDKTAPARPRDSTFLPSLMGGYISGSESASDVDVAPSKKRLGQRQRQAIWEKKFGTRAKHLQRPAKQRGGRDSGWDMKRGAVEGGDDQQRTPWKKGIRNPLTRQAADSKPEVQRPPTKKDDEGPLHPSWAARKQAKASEKTAAFAGSKITFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLK3</accession>
    <name>C7YLK3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_67121</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052508.1">
        <property type="nucleotide sequence ID" value="XM_003052462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YLK3"/>
    <dbReference type="FunCoup" id="C7YLK3">
        <property type="interactions" value="336"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YLK3"/>
    <dbReference type="GeneID" id="9663761"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_67121"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_67121"/>
    <dbReference type="eggNOG" id="KOG3996">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048602_0_0_1"/>
    <dbReference type="InParanoid" id="C7YLK3"/>
    <dbReference type="OMA" id="KARFWLF"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF3">
        <property type="entry name" value="HOLOCYTOCHROME-C SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00821">
        <property type="entry name" value="CYTO_HEME_LYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU46795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="322" mass="36325" checksum="ADD7CC60FEB00939" modified="2009-10-13" version="1">MGWFWAEAAPATVHVPIGHPSVPANADKAPPAGCPMHKKTLDKLNPDAKCQKPQDAPAASGCPVPHAAKTEEKPKSLISQLNPLNYMFPDLSQKPAPNQAFALPTTRDESTIPKGSGDGNWEYPSPQQMYNALLRKGYTDTDITAVEGMVSVHNFLNEGAWQEIIGWEQRFSKGLYKGWQLCKRGEAHFDEELDRQWDGSDSEPTLVRFQGRPKDLTPKATMLQVLGWVYPSKFGTEPPFDRHDWYVSRDINGEKKEVRYVIDYYSGEPEVDGEPVFFLDVRPAMTPQGAAERIIRWSTDVWWKAIGGDRREQDPQPWFRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLV8</accession>
    <name>C7YLV8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_58997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053052.1">
        <property type="nucleotide sequence ID" value="XM_003053006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YLV8"/>
    <dbReference type="GeneID" id="9671088"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_58997"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_58997"/>
    <dbReference type="eggNOG" id="ENOG502S1EZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056292_0_1_1"/>
    <dbReference type="InParanoid" id="C7YLV8"/>
    <dbReference type="OMA" id="IFRDVMA"/>
    <dbReference type="OrthoDB" id="421671at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025638">
        <property type="entry name" value="DUF4336"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835">
        <property type="entry name" value="YALI0C07656P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14234">
        <property type="entry name" value="DUF4336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU47339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="30950" checksum="A662CACBB331240C" modified="2009-10-13" version="1">MSSKLIPSKPEDVMVIRNVTPNIATFSVPFSRYGKIKIGGRGTLVKLTSGSLAVFSPVALTEAAKAKVTEMGGDVRYIVALDFEHHIFVSEWAKAYPSAKLIGPEGLPEKRAKQQDDPKIGNEEFAVVFKKDNKREIRIDPEFDADFDYEYVDGHANLEIVFLYKPERVVIQADLLFNLPPTEQYSKVPEAEVPQDGAIGKVFACVQNPRGDVKWLRRFNWYVASKDKNSFNESMGRIAQWDFATMIPCHGDVMEGDGKEIFQNVFEWHLHGHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7YN52</accession>
    <name>C7YN52_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_67645</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GDT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052777.1">
        <property type="nucleotide sequence ID" value="XM_003052731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YN52"/>
    <dbReference type="FunCoup" id="C7YN52">
        <property type="interactions" value="701"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YN52"/>
    <dbReference type="GeneID" id="9664341"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_67645"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_67645"/>
    <dbReference type="eggNOG" id="KOG2881">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040186_3_0_1"/>
    <dbReference type="InParanoid" id="C7YN52"/>
    <dbReference type="OMA" id="YWWVTIG"/>
    <dbReference type="OrthoDB" id="442680at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015085">
        <property type="term" value="F:calcium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032468">
        <property type="term" value="P:Golgi calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032472">
        <property type="term" value="P:Golgi calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="GDT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049555">
        <property type="entry name" value="GDT1-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN HTP-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="GDT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01214">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988425" description="GDT1 family protein" evidence="9">
        <location>
            <begin position="22"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="498"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="46"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="154"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="380"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="395"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU47064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="55815" checksum="71963C1264D97F4B" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7YN96</accession>
    <name>C7YN96_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_36716</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052797.1">
        <property type="nucleotide sequence ID" value="XM_003052751.1"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YN96"/>
    <dbReference type="GeneID" id="9671329"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_36716"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_36716"/>
    <dbReference type="eggNOG" id="ENOG502QWE7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001023_0_0_1"/>
    <dbReference type="InParanoid" id="C7YN96"/>
    <dbReference type="OMA" id="LHHAHRM"/>
    <dbReference type="OrthoDB" id="2149224at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032065">
        <property type="term" value="P:maintenance of protein location in cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13365">
        <property type="entry name" value="PH_PLC_plant-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053005">
        <property type="entry name" value="Nuclear_Pos-Cytoskel_Interact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024774">
        <property type="entry name" value="PH_dom-Mcp5-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190:SF1">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12814">
        <property type="entry name" value="Mcp5_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="1609"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="358"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="449"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="662"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1297"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1421"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1751"/>
            <end position="1806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1877"/>
            <end position="1912"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="204"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="563"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="664"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="679"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="695"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="728"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1317"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1426"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1443"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1464"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1498"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1524"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1764"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1785"/>
            <end position="1804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1877"/>
            <end position="1894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1901"/>
            <end position="1912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU47084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1912" mass="208889" checksum="7B66E4214AAE08D9" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNV7</accession>
    <name>C7YNV7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Filamentation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_79440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in endocytosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YPP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051896.1">
        <property type="nucleotide sequence ID" value="XM_003051850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNV7"/>
    <dbReference type="STRING" id="660122.C7YNV7"/>
    <dbReference type="GeneID" id="9670878"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79440"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79440"/>
    <dbReference type="eggNOG" id="KOG4162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003276_0_0_1"/>
    <dbReference type="InParanoid" id="C7YNV7"/>
    <dbReference type="OMA" id="KQPPEQD"/>
    <dbReference type="OrthoDB" id="29013at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051722">
        <property type="entry name" value="Endocytosis_PI4K-reg_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083:SF464">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT DOMAIN 7, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN, TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="717"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1066"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="753"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="795"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="857"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="867"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU46183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1194" mass="131799" checksum="FA113D5211327637" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNW3</accession>
    <name>C7YNW3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RTA1 like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_79446</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051899.1">
        <property type="nucleotide sequence ID" value="XM_003051853.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="9672978"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79446"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79446"/>
    <dbReference type="eggNOG" id="ENOG502QU4U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033465_6_1_1"/>
    <dbReference type="InParanoid" id="C7YNW3"/>
    <dbReference type="OMA" id="NCPVEWS"/>
    <dbReference type="OrthoDB" id="4521223at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU46186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="34362" checksum="F8A6574BEF9BD714" modified="2009-10-13" version="1">MPNYNYSIPPEDYFGSDSPCTLDNCKVEWSLLGYRPDLAANIAFIALFGVIGLAHAYLGFRWKAWGFMAGMLMGCLSEVVGYVGRVMMYNNPFSFNAFMIQIVCLTIAPVFYTASIYVTLSKTIVFFAPELSRFKPQLFYWIFIPFDIVCLILQAAGGAMSTSSDNGDVGVDISMAGLILQVIILFLFIVAFSDYMIRYWRSGRAANFGWRLQAFFAGLSAAIILILTRCIYRVAELKDGYDGELIKHEIPFIILEGIMIVLAAIALCFGHPGLVFNKPEYTNAVSESEKGVTLSSLRGSSDGTVINQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7YP22</accession>
    <name>C7YP22_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Conserved oligomeric Golgi complex subunit 6</fullName>
            <shortName evidence="10">COG complex subunit 6</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Component of oligomeric Golgi complex 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_67962</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the conserved oligomeric Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the COG6 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051930.1">
        <property type="nucleotide sequence ID" value="XM_003051884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YP22"/>
    <dbReference type="FunCoup" id="C7YP22">
        <property type="interactions" value="258"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YP22"/>
    <dbReference type="GeneID" id="9673008"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_67962"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_67962"/>
    <dbReference type="eggNOG" id="KOG3758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011361_1_0_1"/>
    <dbReference type="InParanoid" id="C7YP22"/>
    <dbReference type="OMA" id="HSCLDFF"/>
    <dbReference type="OrthoDB" id="272987at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010490">
        <property type="entry name" value="COG6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048369">
        <property type="entry name" value="COG6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048368">
        <property type="entry name" value="COG6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506">
        <property type="entry name" value="COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20653">
        <property type="entry name" value="COG6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06419">
        <property type="entry name" value="COG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01087">
        <property type="entry name" value="COG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric complex COG6 N-terminal" evidence="12">
        <location>
            <begin position="65"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved Oligomeric Golgi complex subunit 6 C-terminal" evidence="13">
        <location>
            <begin position="209"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="661"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="661"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU46217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="695" mass="78154" checksum="01EAE63BBB6D4B1F" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQC2</accession>
    <name>C7YQC2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_79054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051712.1">
        <property type="nucleotide sequence ID" value="XM_003051666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQC2"/>
    <dbReference type="GeneID" id="9668941"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79054"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79054"/>
    <dbReference type="eggNOG" id="ENOG502RKQT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1054069_0_0_1"/>
    <dbReference type="InParanoid" id="C7YQC2"/>
    <dbReference type="OrthoDB" id="5105613at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU45999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="264" mass="29567" checksum="5E8FF92D379DE84F" modified="2009-10-13" version="1">MITGFLQKAIDYGADVWDYRLHSLMAVVLLVTTGAKAADMLRVNEWKGTTDNRCLLWEHIKIYEDRTTGFLRADIQFEFCQNSSQRPSVRCISHLYELRDPSCDHVCPAKLLLVWALRTGAVHEQSWEELKAAIINHPDKTVIWTRPGMPVFVSSTSAKIGNFRNEVSADRSSVFTWLSQVAQSCDDEVIGPKAPKRTRTSKDEGKPATDQFKEPASDAHNNLALDDDEQPSLLVVNARSNVSSRLSLIDASFSEDLCLLEAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQJ6</accession>
    <name>C7YQJ6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_79128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051748.1">
        <property type="nucleotide sequence ID" value="XM_003051702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQJ6"/>
    <dbReference type="GeneID" id="9673572"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79128"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79128"/>
    <dbReference type="eggNOG" id="ENOG502T3GR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_987080_0_0_1"/>
    <dbReference type="InParanoid" id="C7YQJ6"/>
    <dbReference type="OrthoDB" id="5082432at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="2">
        <location>
            <begin position="93"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU46035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="344" mass="39628" checksum="C91EE94CC18E7107" modified="2009-10-13" version="1">MSAIPPPGRAESVPNWIMGLYSETFLKCRGVHPFHASPPQAQTPDSTARVLPQFDEKSQTFIPAEQECVIVALDFRDLCRWKIALNHLGQQNHSYKPITEAGWAYIDARNILRKGIAPGDRGQKLQTLMEQHHWLVEEFRGHWGETCFDREHKPAPYSFAFGKSELVPESKLGHRLNNVFMYLCKLNRTAEEKEQNKLRKVIFLTWDSRLVEMTIERLGLKWFSQPNVEIWDMQQRFVCPGPRLEFALHHLGIRFVDQFFGNLARNSGNVSMFLLQMFLSTFYMADGMRNAFVRGQNLPCLPYSWAGVDLGQVNVPPGQLPTHRPPECKNDNNVPQKSDPKIWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQY8</accession>
    <name>C7YQY8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="2">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NECHADRAFT_37682</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GARS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="2"/>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051814.1">
        <property type="nucleotide sequence ID" value="XM_003051768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQY8"/>
    <dbReference type="STRING" id="660122.C7YQY8"/>
    <dbReference type="GeneID" id="9673723"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_37682"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_37682"/>
    <dbReference type="eggNOG" id="KOG0237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027420_3_0_1"/>
    <dbReference type="InParanoid" id="C7YQY8"/>
    <dbReference type="OMA" id="KATVCKY"/>
    <dbReference type="OrthoDB" id="2018833at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000018">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="entry name" value="Phosphoribosylglycinamide synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PHOSPHORIBOSYLAMINE--GLYCINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINE--GLYCINE LIGASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01209">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="14">
        <location>
            <begin position="115"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU46101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="430" mass="46077" checksum="09271165BC49CEF7" modified="2009-10-13" version="1">MTENLIVLLVGKGAREHALAWKLSQAPSVKKVLVFPGNAGTEGHAKVSNLETNFEATDYRQLAELATEIGVGLVVVGPDDAVVDGIEGFFKDVGIPCFAPTKEAAELEGSKIFAKDFMAKYNIPTATYQNFDDIESAKAYVQGVEHRVVIKADGLAAGKGVVLPETKQEALSELDSIMKADGKFSAAGSSVVIEEFMEGDEVSILTFSDGKTFRSLPPGQDHKRVFEGNKGPNTGGMGVYSPVPFATQEVLDEIDKSILQPTFDGLEKEGRPFVGLLFTGVMITPQGPKVIEYNVRFGDPETQSAMMLLSEDTDLAAVLLACTSGTLSQVNLGIRPGFACNVVVASQGYPGKYATGMPVTLQPCPREVQIFHAGTYRDKGNHDCLRTGGGRVFSVAAWGNTLQEAVEAAYEGARCVQFEGMFSRKDIASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRY6</accession>
    <name>C7YRY6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_100612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050864.1">
        <property type="nucleotide sequence ID" value="XM_003050818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YRY6"/>
    <dbReference type="STRING" id="660122.C7YRY6"/>
    <dbReference type="GeneID" id="9668031"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100612"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100612"/>
    <dbReference type="eggNOG" id="KOG0703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017628_0_0_1"/>
    <dbReference type="InParanoid" id="C7YRY6"/>
    <dbReference type="OMA" id="ASWNMGI"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000081">
        <property type="entry name" value="GTPase activating protein for Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="170"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="516"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU45151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="672" mass="72380" checksum="5F102AB29C24CE04" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7YS07</accession>
    <name>C7YS07_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_69572</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050875.1">
        <property type="nucleotide sequence ID" value="XM_003050829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YS07"/>
    <dbReference type="GeneID" id="9668041"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_69572"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_69572"/>
    <dbReference type="eggNOG" id="KOG0379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030461_1_1_1"/>
    <dbReference type="InParanoid" id="C7YS07"/>
    <dbReference type="OMA" id="FFVHAGC"/>
    <dbReference type="OrthoDB" id="10250130at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019760">
        <property type="term" value="P:glucosinolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435:SF4">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU45162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="515" mass="55629" checksum="8505CAC29C761D49" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSQ1</accession>
    <name>C7YSQ1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_18440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051394.1">
        <property type="nucleotide sequence ID" value="XM_003051348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSQ1"/>
    <dbReference type="GeneID" id="9668317"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_18440"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_18440"/>
    <dbReference type="eggNOG" id="ENOG502SM6F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_6_1_1"/>
    <dbReference type="InParanoid" id="C7YSQ1"/>
    <dbReference type="OMA" id="ACAKTSI"/>
    <dbReference type="OrthoDB" id="2496787at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF160">
        <property type="entry name" value="SAT4 FAMILY MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="3"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU45681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="230" mass="26130" checksum="305AF564FFF05E08" modified="2009-10-13" version="1" fragment="single">LMMIPLNAISIPISRVGLGKDIWNVHPDDITDFLYVSFLFFFWDELLYLGVLPVTKISILLFYLKVFPGKNIRLGCWILIGLNVAYFIAFELVSIFQCTPIEGAWRAWDKEFPAKCNNINMQGWMAAILNIVLDVATLCLPLWELYKLSLSRKKKIQIMLMFSVGFFVTIVSIVRLQSLASYATTSNVTQDYVEIGYWSTIEVPVGILCACMPAIRSLFSLVFPKVFGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSW6</accession>
    <name>C7YSW6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_41345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051434.1">
        <property type="nucleotide sequence ID" value="XM_003051388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSW6"/>
    <dbReference type="STRING" id="660122.C7YSW6"/>
    <dbReference type="GeneID" id="9668433"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_41345"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_41345"/>
    <dbReference type="eggNOG" id="ENOG502QR3J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028760_7_0_1"/>
    <dbReference type="InParanoid" id="C7YSW6"/>
    <dbReference type="OMA" id="HPILVMG"/>
    <dbReference type="OrthoDB" id="444135at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001209">
        <property type="entry name" value="PRK00175.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF16">
        <property type="entry name" value="SERINE O-SUCCINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="128"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="378"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU45721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="511" mass="55985" checksum="4C6655D396BC5C53" modified="2009-10-13" version="1">MRSCRSLAASSRQLRTALAAPAGSLRPVLVQGHRGFAHFGSRQLHCSTVRKSGVASNPAMSFPCLDALETRSAKLSNDDSSDTEPSYTSGATLNYLCKEPLLLDWGGILPEFNIAYETWGELNADKSNVILLHTGLSASSHAHSTEANPKPGWWEKFIGPGGPLDTNKYHVICTNVIGGCNGSTGPSSIDPGNGERYATRFPILTMGDMVRAQFRLLDYLGVDKLYASVGSSMGGMQSLAAGVLFPSRVGRIVSISGCARSHPYSIAMRHTQRQVLMMDPNWNRGFYYGKVPPHAGMKLAREIATVTYRSGPEWEMRFGRRRADSSKPPALCPDFLIETYLDHAGEKWCLNYDPNSLLYVSKAMDLFDLGIENQVATRDRRAEREKQVASGEASTLSSDACSLTLPAQPYEEQPNSHPDPSDETAVPGSRPPEDLIHGLAPLRDIPTLVMGVASDILFPAWQQREVAEAVRLAGNRNVTHMELSEEMSMFGHDTFLLDLKHIGGNLRMFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSZ0</accession>
    <name>C7YSZ0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxymuconolactone decarboxylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_80894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051031.1">
        <property type="nucleotide sequence ID" value="XM_003050985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSZ0"/>
    <dbReference type="STRING" id="660122.C7YSZ0"/>
    <dbReference type="GeneID" id="9668446"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_80894"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_80894"/>
    <dbReference type="eggNOG" id="ENOG502RYNJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070025_3_2_1"/>
    <dbReference type="InParanoid" id="C7YSZ0"/>
    <dbReference type="OMA" id="LVTEMCW"/>
    <dbReference type="OrthoDB" id="104509at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052512">
        <property type="entry name" value="4CMD/NDH-1_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33570">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33570:SF2">
        <property type="entry name" value="CARBOXYMUCONOLACTONE DECARBOXYLASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxymuconolactone decarboxylase-like" evidence="1">
        <location>
            <begin position="47"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU45318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="148" mass="16504" checksum="F228516D26608A3F" modified="2009-10-13" version="1">MSQDSKLDALHKELFEQGLKMRRSVVGDVYVDRALANGSTEFSKPGQELVTEWCWGYAWTRPGLEKKQRSLLNIGMLMALNRGPELAVHVRGARNNGLTELEIREAILHCTTYCGVPAGVEAMKIAERVLDEMSETGEKARELGNKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7YT02</accession>
    <name>C7YT02_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_41526</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051450.1">
        <property type="nucleotide sequence ID" value="XM_003051404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YT02"/>
    <dbReference type="GeneID" id="9666359"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_41526"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_41526"/>
    <dbReference type="eggNOG" id="KOG2820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_0_0_1"/>
    <dbReference type="InParanoid" id="C7YT02"/>
    <dbReference type="OMA" id="DKQPYHE"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF15">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="15"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="450"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="464"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU45737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="479" mass="52608" checksum="4C418CDAECCBA863" modified="2009-10-13" version="1">MATHAVPLAKTDPIIMVGAGIFGLSAAIHLAERGYTNVTIFDKQPYEKTLYSYFEGCDAASADINKIIRAAYGSQTIYQDLSLEAIKGWNSWTEELRRGGSAVPPGMSSTDDLWINNGDLSCTDSDTLPDFEKATIENMNKAGYHDTQLVNNNEDHMRLAKERGFAARLQPFSKRLLGVMDTTGGITLADKACRFALHKAKRLGVRFTLDSVAGKVTSLVQDGSVKIVGVRTADGKTHPAALTIVACGGWTPSLVPSLDGLAETTAGSVVIFKLPEALRQRFSPSNFPAWSFKIADGPDAGLYGFPVDEQGHLKIGYRGTKYTNPRVQLDGRERSVPITRWTEDEQIRKVPTKAVEVICKFTNEYLPELADIDISTTRLCWYTDSFDNHFVIDRVPDKQGLMVVTAGSGHAFKYLPTIGSWIVDIIEGKGMERPTVKAWRWRSLGKDGKPVNELMEGSKGRRALQNTPLTSGQTQVSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7YT09</accession>
    <name>C7YT09_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phenolic acid decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_40690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051453.1">
        <property type="nucleotide sequence ID" value="XM_003051407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YT09"/>
    <dbReference type="GeneID" id="9668452"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_40690"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_40690"/>
    <dbReference type="eggNOG" id="ENOG502RYFT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104261_0_0_1"/>
    <dbReference type="InParanoid" id="C7YT09"/>
    <dbReference type="OMA" id="RYELWCF"/>
    <dbReference type="OrthoDB" id="4415004at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008729">
        <property type="entry name" value="PA_de_COase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40087">
        <property type="entry name" value="PHENOLIC ACID DECARBOXYLASE PADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40087:SF1">
        <property type="entry name" value="PHENOLIC ACID DECARBOXYLASE PADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05870">
        <property type="entry name" value="PA_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988258" description="Phenolic acid decarboxylase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU45740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="22344" checksum="293185DEC3F8BC52" modified="2009-10-13" version="1">MNLKLVFLFLFVTLLKDVIAYPIYQTNGDLDPTFETDIRDTHLIYDYDATDSDGNPEKWRYEIWFFSEDRVVYAIHGGPMAGRKNYQTASYQCVRIGEVWQINWLEETGTIVSLVYDIKGQTISGLLGFSQGHWENAESAHGDKRNPEDFARWRTLAKIGIQTDRFMLTEKANILEQFKGQGELDTIDPTGPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7YT40</accession>
    <name>C7YT40_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_80940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051470.1">
        <property type="nucleotide sequence ID" value="XM_003051424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YT40"/>
    <dbReference type="GeneID" id="9668469"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_80940"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_80940"/>
    <dbReference type="eggNOG" id="ENOG502S5KU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082453_1_0_1"/>
    <dbReference type="InParanoid" id="C7YT40"/>
    <dbReference type="OMA" id="QLGACFE"/>
    <dbReference type="OrthoDB" id="4932428at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU45757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="177" mass="20455" checksum="509D53A7CC90AA86" modified="2009-10-13" version="1">MSSHRSGKKSRRQRPPVRELIRSLTSHQVNTLTELRRIERIAASCEDEDDARAFQEPMTLAWANYVTSNQFLIELHGLTPNYPFCGDIVQDAHLRVLSDPDSNRSWNTAWLCLVKIRDDGLIPLYALLEAGKQEMWGETLPTQEDVEQLASCFELEWRTAVDTMLRHWATPPTWYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7YTB7</accession>
    <name>C7YTB7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_41759</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050720.1">
        <property type="nucleotide sequence ID" value="XM_003050674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YTB7"/>
    <dbReference type="GeneID" id="9668496"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_41759"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_41759"/>
    <dbReference type="eggNOG" id="ENOG502T6FV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026318_0_0_1"/>
    <dbReference type="InParanoid" id="C7YTB7"/>
    <dbReference type="OMA" id="LYVMLQA"/>
    <dbReference type="OrthoDB" id="5217604at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU45007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="55735" checksum="DD05DB74CD8FF303" modified="2009-10-13" version="1" fragment="single">GLVNNNTQVDSPLNSQTLQPPFGLSWPQATLALTTFRRNHTLHFPFITVKEDSAAEDLYKEKPFLFRAIMLVASPLPRSRVVKMKRNTLAYLGYRMLVEEEKTPDLLQGLLVVTAWAHTCYIDEGQVTNLAFLGLGYAHKLGITQMSSPLPEQANIANQSGTSGLTEKMRQVVKTHSLDEQRCVLGLYCILSVISTKQSRSNPLDSAHIDICCNNISASQSPTSSPALEHLVRFIEMSERLSKGFGEPHERTLSRPYAFLLEGNGRRFRADLERLAEVATRNDSASHHQNFQLYHQYTLVRLYEPAVMVADHPDEGVAPFVYLLICLRNCLDAIRSFFDLLLSSSPEDILNRAIITTDQAAFVMVLAARLLLIDAPGWDPAAARQTLNLSTVLGKIQAHIEKAETQNIKAMQEFVAVTGDTLSEEEMTEDSTLGELATKTRPLKEWYETRLEGEYADKMPSMHGFSMEERDGETEEGMTRLGGLLNDIAWNFRPFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7YV48</accession>
    <name>C7YV48_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_85150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050635.1">
        <property type="nucleotide sequence ID" value="XM_003050589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YV48"/>
    <dbReference type="STRING" id="660122.C7YV48"/>
    <dbReference type="GeneID" id="9675017"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85150"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85150"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_4_1"/>
    <dbReference type="InParanoid" id="C7YV48"/>
    <dbReference type="OMA" id="QCVGMPL"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF152">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU44922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="59464" checksum="B2122DDA19C0374C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7YW11</accession>
    <name>C7YW11_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_30036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049805.1">
        <property type="nucleotide sequence ID" value="XM_003049759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YW11"/>
    <dbReference type="GeneID" id="9677174"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_30036"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_30036"/>
    <dbReference type="eggNOG" id="ENOG502QRP4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_0_0_1"/>
    <dbReference type="InParanoid" id="C7YW11"/>
    <dbReference type="OMA" id="CEADIHF"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU44092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="36356" checksum="20890BC89989846C" modified="2009-10-13" version="1" fragment="single">DSASSTASVTASILEYRTIQGRTFHSDRHSTEYFTPNDDQQLQSQDITHHYLTVLLGDKLFLAPIAGGDVKKVLDVGTGSGIWAIDFADQYPQAEVIGSDLSPCQPSWVPPNVQFEVDDATQPWTWKDNEFDFIHIRYLFGAIADWNAIFQQACRCCAPGGWVQSCEADVHFFCDDDTADDPQVAPYLKTWAKLYEAGGAEMKKPFFVQQENLQEKGIEAAGFTDMKVVNYKVGHALYDLNLLPVGGWPKDPKLAEVGRFVKLTMENDIEGYTLFMWHNVLKWPKDEYQIFLMGMRKILANRKVHAYMMVRYVYARKPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7YW36</accession>
    <name>C7YW36_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_74169</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049818.1">
        <property type="nucleotide sequence ID" value="XM_003049772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YW36"/>
    <dbReference type="GeneID" id="9677186"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74169"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74169"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1124816_0_0_1"/>
    <dbReference type="InParanoid" id="C7YW36"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF432">
        <property type="entry name" value="Y, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002987650" evidence="6">
        <location>
            <begin position="21"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU44105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="247" mass="27499" checksum="E7A5E8C6BD12C49C" modified="2009-10-13" version="1">MWSLCKIAFSIQVALGTVSAALIPATRFNQDAVWPQRQAPVEDQLFLSPTTQFTKVQQNDSLCDARSRQWTGKVPVTNGNSLFYWYFESQRYPERAPTILYLTGGPAEASAQPMLTGVGPCLINKHGNDTTFNPFSWTRYYNVIFVDEVAGSGFSKTPEGVDFQPTTAHEVASDVKVFLHKFSTEIFPELGNRAAVPQCETEVLQCRLAETKESCDKAMEACGPIMAAWYPPKHNLVNISGRYDPDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7YW39</accession>
    <name>C7YW39_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_98537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU43900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049613.1">
        <property type="nucleotide sequence ID" value="XM_003049567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YW39"/>
    <dbReference type="GeneID" id="9677188"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_98537"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98537"/>
    <dbReference type="eggNOG" id="KOG4297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_305449_0_0_1"/>
    <dbReference type="InParanoid" id="C7YW39"/>
    <dbReference type="OMA" id="YPAPEHP"/>
    <dbReference type="OrthoDB" id="3565477at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988725" description="Extracellular membrane protein CFEM domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="842"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="926"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU43900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="971" mass="98087" checksum="9E8D01D4C6C4F8A8" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWW2</accession>
    <name>C7YWW2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_45399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049437.1">
        <property type="nucleotide sequence ID" value="XM_003049391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWW2"/>
    <dbReference type="GeneID" id="9666101"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45399"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45399"/>
    <dbReference type="eggNOG" id="ENOG502S6E5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022883_5_0_1"/>
    <dbReference type="InParanoid" id="C7YWW2"/>
    <dbReference type="OMA" id="KHILWLM"/>
    <dbReference type="OrthoDB" id="3061561at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="509"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU43724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="553" mass="63450" checksum="7FA06A236D738853" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWX4</accession>
    <name>C7YWX4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Expressed protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_101117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049444.1">
        <property type="nucleotide sequence ID" value="XM_003049398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWX4"/>
    <dbReference type="GeneID" id="9666106"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101117"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101117"/>
    <dbReference type="eggNOG" id="ENOG502T3G7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135736_1_0_1"/>
    <dbReference type="InParanoid" id="C7YWX4"/>
    <dbReference type="OMA" id="KAVGLEW"/>
    <dbReference type="OrthoDB" id="5043844at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002986606" evidence="1">
        <location>
            <begin position="19"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU43731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="161" mass="17802" checksum="4C359C6796DBE6F4" modified="2009-10-13" version="1">MFTKTVCSLLVLASAAQGFKFTGPEGDTLDVTKNITITWKQENKTTEKELGLFWYTKPDDLLTLSFEIGYNINISAGEYVWSPTDNTRKELGKYKDALTKKSLFRFQAELRDGDEKSQDDVFSDNYTLTGVEEVEANAGSEMMPTWGLVAGGLAAAGLMMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXK9</accession>
    <name>C7YXK9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_94933</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049075.1">
        <property type="nucleotide sequence ID" value="XM_003049029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXK9"/>
    <dbReference type="GeneID" id="9676967"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94933"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94933"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_1_1"/>
    <dbReference type="InParanoid" id="C7YXK9"/>
    <dbReference type="OMA" id="RIMNGIS"/>
    <dbReference type="OrthoDB" id="5667at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF224">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU43362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="407" mass="44002" checksum="FA197E017E3306F9" modified="2009-10-13" version="1">MASNQDSDNHGGFAAWCVVLGAWCTSFCSFGWMNSIGIFQDYYERELLKGYFSSTVAWIPSLEVFFMSAAGPVVGHIYDRHGPRTLIVVGAFMHVFGLMMASISKEYYQLLLAQGVCSAIGAAAIFQPALSSVSGWFDKRRGTAFGVLMTGSSTGGVIFPIVITHLIPKVGYGWAMRIAAFIILFLLVIASLTVKRRVKPTLTKLTAEDLHRPFHELVFLVVLAGFALLSFGLYVPINFLVPSAIADNMSVSLSQYLVSIFNAASLFGRLTAGFLSDKVGRYNMFFIVCNISGILVLALWIPGTRNVANILFAAFFGFFSGAYVSLSPALVAQISPPKEFGYRSGLLFCSSAIPGLVTSPIAGAILSHSHGSYTNMKIYAGVFCLAGTWLVGVARLMKTGPKLLAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7YY17</accession>
    <name>C7YY17_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_62426</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049146.1">
        <property type="nucleotide sequence ID" value="XM_003049100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YY17"/>
    <dbReference type="STRING" id="660122.C7YY17"/>
    <dbReference type="GeneID" id="9666535"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_62426"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_62426"/>
    <dbReference type="eggNOG" id="KOG1695">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039475_3_0_1"/>
    <dbReference type="InParanoid" id="C7YY17"/>
    <dbReference type="OMA" id="SDIYIDW"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF150">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="84"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU43433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="23884" checksum="53A17B8827B890C5" modified="2009-10-13" version="1">MASQSALPVYHYLDIGRLGRGEVVNLFLKDAGIEFKEVRYPYDDTWPAASEKLRQKGITRTGKVPALEYNGLILTQHIPILRYLARELGQYDGETSGDKYFVDAAADVYIDWRYNWVNQLKGVTKDFTNEFLPWYYDVIAQYYAEREGPYLLGDKITYVDFAVYQSLDNDQRIGANPPKLSGPLLKLKEAIEARPKIAAYLKENRVGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7YY64</accession>
    <name>C7YY64_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_46700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU42947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048660.1">
        <property type="nucleotide sequence ID" value="XM_003048614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YY64"/>
    <dbReference type="GeneID" id="9665773"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_46700"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_46700"/>
    <dbReference type="eggNOG" id="ENOG502SIKI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024934_1_1_1"/>
    <dbReference type="InParanoid" id="C7YY64"/>
    <dbReference type="OMA" id="PANQIGW"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF13">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="43693" checksum="93436017FE663C40" modified="2009-10-13" version="1" fragment="single">CDEVKPECGNCRRFGVCCDFSPIPSHVLRPSPASSSGPGRRGRPRSDWASWAEQIRLSSNASNSGLQGAHECLNVTDLELFHNYMTTTANTLHAGDHRERGLWCEGVPRLGFQHPCVLAFLLSLSSYHMARLKPLEARKYLDLAEQHLGTALQTATILLGHINHENSPAAYIISILICFIGFAKGPSPGNLLLISEDQQVPYLNLLRGVRLVISSVGWTSIFSGVLAEYYPKPSVETEMLPLDPTLLEPGIEDWRASLNDVLDLITVFTEDSIAEAYRHEVRVLMGCCEKTFGKGQNATLGAVGKMEVIMMWIYQVGDVYVEGLTRKDPISMLILGHFCVLLRTVERHWFTQGWASHIMNEILAISERSRKWLTWPLAYLSGQSALLNMSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYE3</accession>
    <name>C7YYE3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_47160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048885.1">
        <property type="nucleotide sequence ID" value="XM_003048839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYE3"/>
    <dbReference type="STRING" id="660122.C7YYE3"/>
    <dbReference type="GeneID" id="9665807"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_47160"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_47160"/>
    <dbReference type="eggNOG" id="ENOG502QS5N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_401722_0_0_1"/>
    <dbReference type="InParanoid" id="C7YYE3"/>
    <dbReference type="OMA" id="NWAPINA"/>
    <dbReference type="OrthoDB" id="5370478at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU43172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="772" mass="86344" checksum="413F43C4CB74A1BB" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYK2</accession>
    <name>C7YYK2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphingolipid C(9)-methyltransferase</fullName>
            <ecNumber evidence="14">2.1.1.317</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">NECHADRAFT_47156</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.317" evidence="14"/>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048731.1">
        <property type="nucleotide sequence ID" value="XM_003048685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYK2"/>
    <dbReference type="STRING" id="660122.C7YYK2"/>
    <dbReference type="GeneID" id="9665840"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_47156"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_47156"/>
    <dbReference type="eggNOG" id="ENOG502QS47">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026434_5_0_1"/>
    <dbReference type="InParanoid" id="C7YYK2"/>
    <dbReference type="OMA" id="GFKTWLF"/>
    <dbReference type="OrthoDB" id="412182at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052290">
        <property type="entry name" value="Sphingo_C9-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197:SF1">
        <property type="entry name" value="SPHINGOLIPID C9-METHYLTRANSFERASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197">
        <property type="entry name" value="SYNTHASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEU43018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="521" mass="59864" checksum="D6498FEF9B0E789C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYZ0</accession>
    <name>C7YYZ0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="5">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_62892</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="5"/>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048797.1">
        <property type="nucleotide sequence ID" value="XM_003048751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYZ0"/>
    <dbReference type="FunCoup" id="C7YYZ0">
        <property type="interactions" value="656"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YYZ0"/>
    <dbReference type="GeneID" id="9665644"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_62892"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_62892"/>
    <dbReference type="eggNOG" id="KOG0225">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029393_5_2_1"/>
    <dbReference type="InParanoid" id="C7YYZ0"/>
    <dbReference type="OMA" id="LGYEMPC"/>
    <dbReference type="OrthoDB" id="10256198at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000013">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050642">
        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF60">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="6">
        <location>
            <begin position="83"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU43084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="409" mass="45299" checksum="6F5139D22CB7034D" modified="2009-10-13" version="1">MLSRALRVPRAVPLRAKLAAPSYIAARSVTTNAASASLSHSVPQSDDEPFVVNLSDESFETYELDPPPYSLEVTKKELKQMYYDMVSIRQMEMAADRLYKEKKIRGFCHLSTGQEAVAVGIEHAITKADDIITAYRCHGFALMRGATVKSIIGELLGRREGISYGKGGSMHMFYKGFYGGNGIVGAQVPVGAGLAFAHKYNGNKNASIILYGDGASNQGQVFEAFNMAKLWNLPALFGCENNKYGMGTSAARSSALTDYYKRGQYIPGLKVNGMDVLAVKAAVKYGKEWTAADKGPMVLEYVTYRYGGHSMSDPGTTYRTREEIQRMRSTNDAIAGLKQKILDWEVTTEDELKKIDKEARAHVNEEVAIAEGMAVPDPKPEILYEDTYVKGSEPQYLRGRILEENYYFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZP7</accession>
    <name>C7YZP7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_71372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048358.1">
        <property type="nucleotide sequence ID" value="XM_003048312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZP7"/>
    <dbReference type="STRING" id="660122.C7YZP7"/>
    <dbReference type="GeneID" id="9667626"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_71372"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_71372"/>
    <dbReference type="eggNOG" id="KOG4313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048013_0_0_1"/>
    <dbReference type="InParanoid" id="C7YZP7"/>
    <dbReference type="OMA" id="CIKAEST"/>
    <dbReference type="OrthoDB" id="10261522at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03676">
        <property type="entry name" value="NUDIX_Tnr3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000019">
        <property type="entry name" value="Thiamin pyrophosphokinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF11">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="129"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="309" mass="34117" checksum="5679BBC8ECAEFFD1" modified="2009-10-13" version="1">MTKLLDLVTQIDNAPLNFETDHHPYYRLYLAPDPRPHGYILPDTVSRMPWPADFTISHDDRSVTLSAPPPGETLTTHANAAFQKAVDGAIDGDLFPILHQEHSEPFLVVGARSFVQIERFAAPLFGIATRGAHMTGYARGTDGKIKIWVARRSRHLFSYPGLLDSTVAGGIKASNTPLECILAESVEEACLPVDLVSSKVQAADAVTLANINERSGLHHSDILYVYDLEIPDGVVPKPGDDEVEEFVLMECGEVVKRMLAGEFKPNVCPVLIDFLVRHGEITAENEDDFAEIQARLRRKIPVPMESDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZY8</accession>
    <name>C7YZY8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Expressed protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_101443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048590.1">
        <property type="nucleotide sequence ID" value="XM_003048544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZY8"/>
    <dbReference type="GeneID" id="9667667"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101443"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101443"/>
    <dbReference type="HOGENOM" id="CLU_906402_0_0_1"/>
    <dbReference type="InParanoid" id="C7YZY8"/>
    <dbReference type="OrthoDB" id="5397087at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="307" mass="34416" checksum="368F9C6F9A9EB354" modified="2009-10-13" version="1">MTSSKRSRDDYRERAYVAASRRTDRNVKARMESALMASEIHRKRTGKPLHITEDIVMGDAPYEEEQETWPRPQTYPVVPKSNTNMGVGVVSKESLASAVFAKTEEEWRESEINRLFAEAFPNFGKQSKLLVPTIVPTIPKEDKPPREPTSQNAEGVDKQHQHEHLQNVIPPYQPDEQTGDTPSRPREDSLLGETPSLLGSDSATLTSCSPSFIPDLSNLAAMPSEFFDPNMTEGLFANDYSAIGEGFNFKTDDFAHDGDVNEWLQHVCDSGDMLEMAGWDSQPFDGTMDDWWPMLIDDSAQLVTSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z049</accession>
    <name>C7Z049_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_84252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048624.1">
        <property type="nucleotide sequence ID" value="XM_003048578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z049"/>
    <dbReference type="GeneID" id="9667701"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84252"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84252"/>
    <dbReference type="eggNOG" id="ENOG502RJ9R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_473327_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z049"/>
    <dbReference type="OrthoDB" id="5063409at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="576" mass="63447" checksum="0F28D5E439203C9F" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0G0</accession>
    <name>C7Z0G0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Globin-sensor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_39969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047909.1">
        <property type="nucleotide sequence ID" value="XM_003047863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0G0"/>
    <dbReference type="GeneID" id="9671894"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_39969"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_39969"/>
    <dbReference type="eggNOG" id="ENOG502S0AP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063074_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z0G0"/>
    <dbReference type="OMA" id="RVEVMHM"/>
    <dbReference type="OrthoDB" id="10027058at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Globin-sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42071:SF1">
        <property type="entry name" value="GLOBIN-SENSOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42071">
        <property type="entry name" value="PROTOGLOBIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11563">
        <property type="entry name" value="Protoglobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin-sensor" evidence="1">
        <location>
            <begin position="18"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="237" mass="26661" checksum="89A733571849CA5A" modified="2009-10-13" version="1">MSTEMEHIDRKSLYTSLEARIDYLHKFLDFDDRDLEALAFGSKFVKDLIPAVVHIVYRKLLQFDITARAFEIRDTTSEAPLQSVLDDNSPELQERKNFLNSYLTKICSDQSKMAFWEYLDNVGAMHVGLRRSKPLRVEYIHISATLCVIQHVLTESILSHSVLPMSRRVAMVKALSKVIWIQNDLFAKWCVRDGEEFTGGPAAAARADQLASAGDVPLKESAVSTCPFSGMTSGVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0I2</accession>
    <name>C7Z0I2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_93219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047921.1">
        <property type="nucleotide sequence ID" value="XM_003047875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0I2"/>
    <dbReference type="STRING" id="660122.C7Z0I2"/>
    <dbReference type="GeneID" id="9667270"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_93219"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_93219"/>
    <dbReference type="eggNOG" id="ENOG502SS15">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024110_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z0I2"/>
    <dbReference type="OMA" id="AESYWMT"/>
    <dbReference type="OrthoDB" id="3532430at2759"/>
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        <property type="component" value="Chromosome 5"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="655"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="130"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="488"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="655"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU42208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="715" mass="79967" checksum="090EB3495F9C8DC7" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0L9</accession>
    <name>C7Z0L9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">allantoinase</fullName>
            <ecNumber evidence="6">3.5.2.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_93239</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-allantoin + H2O = allantoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17029"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15678"/>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
            <dbReference type="EC" id="3.5.2.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nitrogen metabolism; (S)-allantoin degradation; allantoate from (S)-allantoin: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.5" evidence="6"/>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047936.1">
        <property type="nucleotide sequence ID" value="XM_003047890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0L9"/>
    <dbReference type="FunCoup" id="C7Z0L9">
        <property type="interactions" value="1264"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z0L9"/>
    <dbReference type="GeneID" id="9671921"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_93239"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_93239"/>
    <dbReference type="eggNOG" id="KOG2584">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015572_4_0_1"/>
    <dbReference type="InParanoid" id="C7Z0L9"/>
    <dbReference type="OMA" id="SRLHVCH"/>
    <dbReference type="OrthoDB" id="10258955at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009442">
        <property type="term" value="P:allantoin assimilation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Allantoinase Dal1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF2">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01137">
        <property type="entry name" value="TATD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="10">
        <location>
            <begin position="74"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase 3" evidence="11">
        <location>
            <begin position="416"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU42223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="526" mass="56645" checksum="14475685C0C8D583" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z156</accession>
    <name>C7Z156_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_40437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048018.1">
        <property type="nucleotide sequence ID" value="XM_003047972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z156"/>
    <dbReference type="STRING" id="660122.C7Z156"/>
    <dbReference type="GeneID" id="9671829"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_40437"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_40437"/>
    <dbReference type="eggNOG" id="ENOG502QTKU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028866_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z156"/>
    <dbReference type="OMA" id="EITQVAH"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000911">
        <property type="entry name" value="Chromosome 8, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF7">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G10190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="19"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="387" mass="42878" checksum="C351D83666E51EE3" modified="2009-10-13" version="1">MGSVPTQQPETSQGDSRILRVGIIGCGEISQVAHIPNINFLSHKFQTTYLCDISKQALAHCAKKVQGGTPKTTIDPAELCSSPDVDVVLIANADAYHVEHGIIALQNDKYCLIEKPAALCFRDLDRLVKAESTSRGKVFVGTMRRYATAFIDAVKEVGGMQNIQYARVRDIIGPNSVFVDQSGTFPQKFSDFTEADGEDRVKRETDIQEQALGKEFDVPITPKSKRMLRVLGGLGTHDLSAMREILGMPKRVAGACLTFPGIFSVLFEYDGFPVSYESGLNGVPQFDAHIEVYSQDKIVRVNYDSPYVKGLPVTLTIREKIGEDGFQERVIRKTYQDPYTLEMLELYDCVVGNKTPKTSAADARNDIELFRMIIKADEGRYKAEASS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-07-27" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z274</accession>
    <name>PFF1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vacuolar membrane protease</fullName>
            <ecNumber evidence="6">3.4.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">FXNA-related family protease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">NECHADRAFT_96958</name>
    </gene>
    <organism>
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in vacuolar sorting and osmoregulation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M28 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="6"/>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU42122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047835.1">
        <property type="nucleotide sequence ID" value="XM_003047789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z274"/>
    <dbReference type="SMR" id="C7Z274"/>
    <dbReference type="FunCoup" id="C7Z274">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z274"/>
    <dbReference type="EnsemblFungi" id="NechaT96958">
        <property type="protein sequence ID" value="NechaP96958"/>
        <property type="gene ID" value="NechaG96958"/>
    </dbReference>
    <dbReference type="GeneID" id="9671620"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_96958"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_96958"/>
    <dbReference type="eggNOG" id="KOG2194">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006412_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z274"/>
    <dbReference type="OMA" id="FCHTFVN"/>
    <dbReference type="OrthoDB" id="76293at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03875">
        <property type="entry name" value="M28_Fxna_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048024">
        <property type="entry name" value="Fxna-like_M28_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053975">
        <property type="entry name" value="PFF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053976">
        <property type="entry name" value="PFF1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF58">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22250">
        <property type="entry name" value="PFF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22251">
        <property type="entry name" value="PFF1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000411725" description="Vacuolar membrane protease">
        <location>
            <begin position="1"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=1" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="topological domain" description="Vacuolar" evidence="1">
        <location>
            <begin position="33"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=2" evidence="3">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="448"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=3" evidence="3">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="topological domain" description="Vacuolar" evidence="1">
        <location>
            <begin position="504"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=4" evidence="3">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="533"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=5" evidence="3">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="topological domain" description="Vacuolar" evidence="1">
        <location>
            <begin position="567"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=6" evidence="3">
        <location>
            <begin position="574"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="595"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=7" evidence="3">
        <location>
            <begin position="709"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="topological domain" description="Vacuolar" evidence="1">
        <location>
            <begin position="730"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=8" evidence="3">
        <location>
            <begin position="746"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="767"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=9" evidence="3">
        <location>
            <begin position="774"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="topological domain" description="Vacuolar" evidence="1">
        <location>
            <begin position="795"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="616"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="616"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="632"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="2">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="812"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P38244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P80561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="1032" mass="115781" checksum="1AD96ED492831F6C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z371</accession>
    <name>C7Z371_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_54281</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047319.1">
        <property type="nucleotide sequence ID" value="XM_003047273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z371"/>
    <dbReference type="GeneID" id="9675928"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_54281"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_54281"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="InParanoid" id="C7Z371"/>
    <dbReference type="OMA" id="MTNGMQV"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="36"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU41606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="510" mass="56938" checksum="796364B25B045B42" modified="2009-10-13" version="1">MAPKVARATEDIQSPIDLKSVPPFWKRKNGVLLYFLLTSSLLASMALGIDGSMTNALQTLESWQEKFGHPTGSKLGFFGASNAIGGVIPFIFLSWIGDVAGRRVPTALGSIVIIAGVIVQFFATSLNMFIGGKIVLGIGSSLIQMGAPVLVTELSHPKERVQITTLYNTNIVLGYVIGAWATYGCFRIESDWSWKLPTLVQIVPSAYQLSLIFFCPESPRWLIAKGKLDKARDILIKYHGECDADSELVKFECTEIQQAIAKEAEQNMTWKDFFSSIPNLKRISLCFATALFSQSSGNLLVSNYLTQILKDTGIEAEKDITLVNGMVTLWQYIVAITMAMLVDRFRRRTFFLFGSGGVLVTFIMWTIAAKQYLDGSLAGGRVVLACIFLFQGFYSSAWTNLVVTYPLEIVTYQMRAKTWAFVLLTIQVASIFGGYVNPIGLEAIGWKFYIYYCVWVAIVFLVVYFFFVETSGPTLEELTYLFEGKDAKQDMAKVIEIKKEEQEFGREKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z3R2</accession>
    <name>C7Z3R2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_83339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046893.1">
        <property type="nucleotide sequence ID" value="XM_003046847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z3R2"/>
    <dbReference type="GeneID" id="9675478"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83339"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83339"/>
    <dbReference type="eggNOG" id="ENOG502SP5N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024934_0_4_1"/>
    <dbReference type="InParanoid" id="C7Z3R2"/>
    <dbReference type="OMA" id="DLELMHQ"/>
    <dbReference type="OrthoDB" id="3546279at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU41180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="44992" checksum="3E0CC962DE2B976E" modified="2009-10-13" version="1">MPRLGYKKSRKGCLRCKQRRLLIVSVTKNNHAPLAQGTALPASFRNIRMQQDRLLDLEILTSQTDLRRDWVSPSMSPDPYPYFAKFVTGQEPVEKSTWLTDLELMHHYTFSTYLTLPRANELQQVWQVEVPKLALAHAFLLHQVLSVSAHHLAYLHPDRPTLSICASQHQNKAVVGLRTAVPTITEENCPEIFVASSLLYICAFASFSTPSRDEQPRIDDLVDVFLLIRGMSDILNSYNDALTASKLGMLFMRGDASEPSPILSAMVEKLRQLEIPNAFDPETTNLCRESILSSINWIENCVATTRMPDLRVAMSWSLSLEPEFMDLVRRHHPIALCVIGHYCVILHHTGLDHWFLRGWGKPILSDIMEKIDPEWKCLLEWPLVAIGANEANGMRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z3T5</accession>
    <name>C7Z3T5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Signal recognition particle 54 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NECHADRAFT_70802</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting. SRP54 binds to the signal sequence of presecretory protein when they emerge from the ribosomes. SRP54 interacts with the scR1 RNA and mediates the association of the resulting SRP-RNC complex with the signal recognition particle receptor (SR) via its alpha subunit SRP101. Both, SRP54 and SRP101, are locked in their GTP bound forms in the SRP-RNC-SR complex, which dissociates upon transferring the signal sequence to the protein-conducting channel (translocon). After signal sequence transfer, SRP54 and SRP101 act as reciprocal GTPase-activating proteins (GAPs), thereby resolving their association.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Fungal signal recognition particle consists of a 7S RNA molecule (scR1) and at least six protein subunits: srp72, srp68, srp54, sec65, srp21 and srp14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The M domain binds the 7SL RNA and the signal sequence of presecretory proteins.</text>
    </comment>
    <comment type="domain">
        <text evidence="13">The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit srp101. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046905.1">
        <property type="nucleotide sequence ID" value="XM_003046859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z3T5"/>
    <dbReference type="FunCoup" id="C7Z3T5">
        <property type="interactions" value="990"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z3T5"/>
    <dbReference type="GeneID" id="9675746"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_70802"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_70802"/>
    <dbReference type="eggNOG" id="KOG0780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_6_1_1"/>
    <dbReference type="InParanoid" id="C7Z3T5"/>
    <dbReference type="OMA" id="GMTGQDA"/>
    <dbReference type="OrthoDB" id="10250817at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.30:FF:000003">
        <property type="entry name" value="Signal recognition particle 54 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000022">
        <property type="entry name" value="Signal recognition particle 54 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006325">
        <property type="entry name" value="SRP54_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01425">
        <property type="entry name" value="SRP54_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="14">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU41192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="518" mass="55861" checksum="0D32D055B0F97042" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4J7</accession>
    <name>C7Z4J7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Activating signal cointegrator 1 complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_76546</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046072.1">
        <property type="nucleotide sequence ID" value="XM_003046026.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="C7Z4J7">
        <property type="interactions" value="616"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z4J7"/>
    <dbReference type="GeneID" id="9678454"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76546"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76546"/>
    <dbReference type="eggNOG" id="KOG0952">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000335_2_0_1"/>
    <dbReference type="InParanoid" id="C7Z4J7"/>
    <dbReference type="OMA" id="MCSATEF"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:nucleic acid binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="DEXHc_ASCC3_1"/>
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    </dbReference>
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        <property type="entry name" value="DEXHc_ASCC3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Activating signal cointegrator 1 complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
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    </dbReference>
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        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
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    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000009">
        <property type="entry name" value="DEAD/DEAH box helicase, putative"/>
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    </dbReference>
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        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
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    </dbReference>
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        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
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    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF13">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="285"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="509"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="1145"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="1350"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1951"/>
            <end position="1970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU40359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1970" mass="220801" checksum="2DEE44D1EE368C25" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4M8</accession>
    <name>C7Z4M8_FUSV7</name>
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        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_33155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046088.1">
        <property type="nucleotide sequence ID" value="XM_003046042.1"/>
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    <dbReference type="AlphaFoldDB" id="C7Z4M8"/>
    <dbReference type="STRING" id="660122.C7Z4M8"/>
    <dbReference type="GeneID" id="9678469"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_33155"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_33155"/>
    <dbReference type="eggNOG" id="ENOG502SJ77">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005936_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z4M8"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF2">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU40375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="708" mass="78775" checksum="E4F60E8C0A076952" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z578</accession>
    <name>C7Z578_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_91279</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU41052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046765.1">
        <property type="nucleotide sequence ID" value="XM_003046719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z578"/>
    <dbReference type="FunCoup" id="C7Z578">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z578"/>
    <dbReference type="GeneID" id="9678293"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_91279"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_91279"/>
    <dbReference type="eggNOG" id="KOG0703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023062_3_3_1"/>
    <dbReference type="InParanoid" id="C7Z578"/>
    <dbReference type="OMA" id="SDCKRNK"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="term" value="F:GTPase activator activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="3">
        <location>
            <begin position="17"/>
            <end position="134"/>
        </location>
    </feature>
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        <location>
            <begin position="161"/>
            <end position="250"/>
        </location>
    </feature>
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        <location>
            <begin position="265"/>
            <end position="548"/>
        </location>
    </feature>
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        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
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        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="360"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="432"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="464"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="516"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU41052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="548" mass="56426" checksum="3268E3096C11C710" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z628</accession>
    <name>C7Z628_FUSV7</name>
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        <recommendedName>
            <fullName evidence="7">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="7">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_57828</name>
    </gene>
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        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
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            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
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        </reaction>
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    <dbReference type="Proteomes" id="UP000005206">
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
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        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
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        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF169">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PLC-like phosphodiesterases"/>
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    </dbReference>
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        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="426"/>
        </location>
    </feature>
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        <location>
            <begin position="267"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU40055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="581" mass="64802" checksum="473C834852F36F41" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8Z7</accession>
    <name>C7Z8Z7_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_43505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045023.1">
        <property type="nucleotide sequence ID" value="XM_003044977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8Z7"/>
    <dbReference type="GeneID" id="9672933"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_43505"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_43505"/>
    <dbReference type="eggNOG" id="ENOG502SE07">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168419_1_1_1"/>
    <dbReference type="InParanoid" id="C7Z8Z7"/>
    <dbReference type="OMA" id="YWNKMTE"/>
    <dbReference type="OrthoDB" id="5395727at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="91" mass="10365" checksum="9E8621746DC27107" modified="2009-10-13" version="1">MEQPINNPQGTEQPVVDQSPVVGSSPQDRRASDAQDRRMSDEWDASKVPPSRFQKRKGSIYATPGSRDGHVDRNYADKYWSKMTEKNWVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9L3</accession>
    <name>C7Z9L3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extradiol ring-cleavage dioxygenase class III enzyme subunit B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_94508</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044832.1">
        <property type="nucleotide sequence ID" value="XM_003044786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9L3"/>
    <dbReference type="STRING" id="660122.C7Z9L3"/>
    <dbReference type="GeneID" id="9673817"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94508"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94508"/>
    <dbReference type="eggNOG" id="ENOG502QS66">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046582_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z9L3"/>
    <dbReference type="OMA" id="AGPCFFM"/>
    <dbReference type="OrthoDB" id="7396853at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF0">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="6">
        <location>
            <begin position="10"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU39119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="284" mass="31238" checksum="40F31BCDC4CCC482" modified="2009-10-13" version="1">MAKVAPVVALSHGGGPMPLLDDPSHKDIIYSLKNRVPKILKLGTPEQPRAIVLVTAHWSTDKPTISSGASHRLLYDYYGFPRETYSLKYPAPGHPEVAREVADALKEEGLEPELDDERGWDHGVFIPLLLVNPKADVPVVQMSVLESEDPEQHLRMGKALARLRASNVAIIGSGFASFHNLGIMRQLMMAGPSQRAQFRGVSDAWNRALTDATVSKDRNEALKGWRKFPHADTMHPPHGGEHFMPLLVCAGAAVEGEETGRYSDEFAGVEINTYYWGADKNGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9V0</accession>
    <name>C7Z9V0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_70420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044877.1">
        <property type="nucleotide sequence ID" value="XM_003044831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9V0"/>
    <dbReference type="FunCoup" id="C7Z9V0">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z9V0"/>
    <dbReference type="GeneID" id="9672233"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_70420"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_70420"/>
    <dbReference type="eggNOG" id="KOG0874">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043293_0_1_1"/>
    <dbReference type="InParanoid" id="C7Z9V0"/>
    <dbReference type="OMA" id="FFIFWDR"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102772">
        <property type="term" value="F:sphingolipid C4-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042284">
        <property type="term" value="F:sphingolipid delta-4 desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="216"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="354"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU39164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="374" mass="42500" checksum="7586CAC0B4F6C249" modified="2009-10-13" version="1">MGNDSSILADGSAMAAPGSPFNQTLFETALPPLPTFSLETRPDLLSWMSDFWLSLVIPVVVYWALSLTFHAIDVYDYFPQYRLHTPEEITKRNHVSRYEVARDVILQQVIQVITGAILAMTEPPEMVGKSEYDVAVWATRIRVAQRVLPTVLGVFGFNATAISKSLLESHPLLAGALAGGYYPSLVTATNEPAFASWEINVAKVIYHFLIPAVQFFVAISIIDTWQYFLHRLMHVNKWLYAHFHSRHHRLYVPYAYGALYNHPVEGFLLDTLGAAISFKATFMTVRQGMWLFAMSTIKTVDDHCGYEFPWDPLQLITSNNAAYHDIHHQHWGIKTNFAQPFFTFWDTLLDTKYKGKRSNHPSGIKKAKTEAKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAS2</accession>
    <name>C7ZAS2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_88920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698913">
        <property type="protein sequence ID" value="EEU38909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044622.1">
        <property type="nucleotide sequence ID" value="XM_003044576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAS2"/>
    <dbReference type="GeneID" id="9672930"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88920"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88920"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_16_1_1"/>
    <dbReference type="InParanoid" id="C7ZAS2"/>
    <dbReference type="OMA" id="IGYHGVT"/>
    <dbReference type="OrthoDB" id="9992527at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF7">
        <property type="entry name" value="ZINC BINDING OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="2"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU38909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="353" mass="38387" checksum="54B64AB5D4480DB1" modified="2009-10-13" version="1">MATMKALVVTPRDKLLYTANPVATQDRRIIGSDFTGVITKVSTDVEKLDDPRTQVGTRVASFVQGACSVNERAGAFAQYVCVEWDLAWHVPDDMPLEEAASISMCGLTAAQGLFSRLKIPCPFSKTEGFDRLNLRSGEEVNFLIYGATASLGLFAAQLVRLSEQVSGTKIRLIGLASASNHDLLREEPYKFDVLIDYHDADWPEQVRKLTESSGGVHYAVDTISISPSVEQVESTLAPDGRFAVYRSPALGKFDINKLHHKPMIGAVWEGLGVEIGYQGASIPANPEARRFAAEFFAFLGSEGSQRKAKLAGNPIRQMPGGLEKIAEGLALVSPNKMPEVRPISAEKAVYTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZB17</accession>
    <name>C7ZB17_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_101148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044543.1">
        <property type="nucleotide sequence ID" value="XM_003044497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZB17"/>
    <dbReference type="GeneID" id="9672733"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101148"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101148"/>
    <dbReference type="HOGENOM" id="CLU_1230232_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZB17"/>
    <dbReference type="OrthoDB" id="5235778at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="225" mass="24705" checksum="648987951975D35D" modified="2009-10-13" version="1">MRLTRSRKSRIDTSLAKTSQEAPTPTSDPSDSTDASSPVIVVLPKSQEESPTHGPADSSLAKQPIVNGNPKLRRRARGSGGTKSDKDSSSLSRDPLSKRPRSIPAKRRVPGLLQRIKDRADIEISRAEDAQERADLQIKWKRTTPTPTPSIGGEAHDKIKDTQTWPDQVALQIRPREDAAYNGDVVYQRKSHGPLLGKLASQGSVITIDGEDYVEYRVLAKLRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZB38</accession>
    <name>C7ZB38_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_83195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044456.1">
        <property type="nucleotide sequence ID" value="XM_003044410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZB38"/>
    <dbReference type="FunCoup" id="C7ZB38">
        <property type="interactions" value="246"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZB38"/>
    <dbReference type="GeneID" id="9670772"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83195"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83195"/>
    <dbReference type="eggNOG" id="KOG3035">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051989_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZB38"/>
    <dbReference type="OMA" id="DSHTQKG"/>
    <dbReference type="OrthoDB" id="671439at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd01838">
        <property type="entry name" value="Isoamyl_acetate_hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045136">
        <property type="entry name" value="Iah1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209:SF19">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="242" mass="27187" checksum="3CCE72710BF791A5" modified="2009-10-13" version="1">MATTYPQLVLFGDSLLQGSIDIQDGFSFQAALQTRLIRRFDVVNRGFAGWNSKNALEYFPKIFPAPSDQSPKLDYLIVLFGANDAIVPHPASTRHVPVDDYKLNLIRLINHAHIRSHRPKFFLVTPTPVDEDKLNSLGHEPRTLAHTGLYAEAVREVAKENPDIILIDLWQAVVEKATHTTTQANKSNLTTESPAANFDGLFTDGLHLSAVAYKLFYDLVTPYLPEGQPSQYIYPDWKDLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBA0</accession>
    <name>C7ZBA0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dynamin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_45679</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        <location>
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            <end position="315"/>
        </location>
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        <location>
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        </location>
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        <location>
            <begin position="669"/>
            <end position="688"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51718"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="688" mass="77937" checksum="E5432FAF6C04113B" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZD88</accession>
    <name>C7ZD88_FUSV7</name>
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        <recommendedName>
            <fullName evidence="1">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_101491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
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        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698919">
        <property type="protein sequence ID" value="EEU38179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003043846.1"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101491"/>
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    <dbReference type="HOGENOM" id="CLU_020027_11_1_1"/>
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    <dbReference type="OrthoDB" id="428260at2759"/>
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        <property type="component" value="Chromosome 9"/>
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        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
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            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="412" mass="45335" checksum="E8783464FF6C4E36" modified="2009-10-13" version="1">MPLDSNVVTKLRGIVDGACADTTAGIPGTSVVVVGKSGEELFAHAAGKRGVNSQEPMTLDNVFWIASCTKMLAGVAVMQLVEQGLLKLDDGEQTEKIVPELKELKVLNKDGKLEDKKRAITLRMLLTHTSGCAYTFFNERLRDWTLPAGYDEFSGRLEDIKMPLVFQPGEGWEYGVGIDWAGLALERVSGLSLNDYLQKHVFQPLGIKNMSMLPGKDMRSRLAYMHARDPDGKLRPRDHLLRLPLVVDPDNKSETAALFNSGGAGMFAQPQEYCKVLAVLLNDGTCPRTGAKILRKETVDEMFRNQIEKFPNASRQFIPAAKPDLTNPIPELYPVSGNPPQGWGLTFMMSNGGGTGRSKGTVHWAGLANLWWWCDRENGVAGMVCTQILPFADAKVLGLWAEVEAEIYKAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDF3</accession>
    <name>C7ZDF3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_88180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043605.1">
        <property type="nucleotide sequence ID" value="XM_003043559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZDF3"/>
    <dbReference type="STRING" id="660122.C7ZDF3"/>
    <dbReference type="GeneID" id="9669706"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88180"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88180"/>
    <dbReference type="eggNOG" id="ENOG502SVVP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_794741_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZDF3"/>
    <dbReference type="OMA" id="HAMIMLR"/>
    <dbReference type="OrthoDB" id="4158087at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="12"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU37892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="349" mass="38394" checksum="73865DD3DAFE8CA7" modified="2009-10-13" version="1">MPQYKFVAVQGDDGKLSKVSSSTRSHAVRAGLRKTKRRPRSKATTASSGSTESRQDVICGFGLSLKSVCPSCVDPFNSLPVPTNLQVDHLVKYHAADRSRAWFPYALQSVPMMHSTLAMAATQWRAECPSLEQSIQVEGLRQKGEAMREIGSRLAQDCSGYDDEMAFLMSTMATLAIVEVSDGSFDAAEIHLEGVQNLFSLRGGYGNLKDYFILCKSINIADILVATALGQGLIFPLMHTDQPQLPPIILEHPFDPPLHDSVPDASACCSRIFAKLRQLLLATQSLMISVDDLRTLLNIVDESILRHLYQNPVDQSDTSRRSRALVLAAQIFILHWAARTRVSGRAVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEJ8</accession>
    <name>C7ZEJ8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_53688</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="GG698921">
        <property type="protein sequence ID" value="EEU37610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043323.1">
        <property type="nucleotide sequence ID" value="XM_003043277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEJ8"/>
    <dbReference type="GeneID" id="9669133"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_53688"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_53688"/>
    <dbReference type="eggNOG" id="KOG0496">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005732_2_1_1"/>
    <dbReference type="InParanoid" id="C7ZEJ8"/>
    <dbReference type="OMA" id="GGCPGDI"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.20.10:FF:000001">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000040">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.390.10">
        <property type="entry name" value="Beta-galactosidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025972">
        <property type="entry name" value="BetaGal_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036833">
        <property type="entry name" value="BetaGal_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13363">
        <property type="entry name" value="BetaGal_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117100">
        <property type="entry name" value="Beta-galactosidase LacA, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002987046" description="beta-galactosidase" evidence="9">
        <location>
            <begin position="29"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase" evidence="10">
        <location>
            <begin position="406"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU37610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1028" mass="115194" checksum="28478B048BD32AAA" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZER4</accession>
    <name>C7ZER4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_86237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043134.1">
        <property type="nucleotide sequence ID" value="XM_003043088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZER4"/>
    <dbReference type="GeneID" id="9665184"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86237"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86237"/>
    <dbReference type="eggNOG" id="ENOG502SPRK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039760_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZER4"/>
    <dbReference type="OMA" id="ECAFALP"/>
    <dbReference type="OrthoDB" id="515692at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF4">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="1">
        <location>
            <begin position="209"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="370" mass="42098" checksum="B2809286D6879F8D" modified="2009-10-13" version="1">MRTYKDPVCPPTVRSQISRYPVLGTQHPTPNTTYSCAFMKKTLKKWVIAKLDKLQGKDPTIPRLPDQRKYALTTEYLLASESPFFKKLPYEIRQGILMFAFGNRLIHIDLSLAHPTRNAINANPTFFITNDHCGRARVVWPLSPIDTGKPKCWQWRGCLCHRIPPDSRGDFHDRARNIPQPGDDRCCMGFGASCDQWPGQLPNKCWIGIMGWLLTCRQSYVEGIQVLYATNTIHIASKALLTHIPSVILPQRLMAISSLEISWNIGAHEHEGIIFLNQDDLESILTILFSHFPALRSLHLALKMQVNIQLPVHLGATLRVLDSFVRNTNLKFTVSVTSSVFRQLYRTVRGGITGGNLLFSDYQLWRHLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZES0</accession>
    <name>C7ZES0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_97074</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043052.1">
        <property type="nucleotide sequence ID" value="XM_003043006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZES0"/>
    <dbReference type="GeneID" id="9665243"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_97074"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_97074"/>
    <dbReference type="eggNOG" id="ENOG502SHGZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070115_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZES0"/>
    <dbReference type="OMA" id="LVAFYWW"/>
    <dbReference type="OrthoDB" id="5421689at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF92">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="23"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU37339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="350" mass="39026" checksum="BEB44A72F0C12535" modified="2009-10-13" version="1">MNINTSIGIQAVLLVLALVVLLLRCWANYLMKQSLLSVPDIFAWLGWVFSLGWFVCSTLALRILIENPAVGSELVVNSVEYLKIVLVAEYFFDTGIYFPKISIVLVYWKLIPGIFGSLRRVLLVTSIYLGCALLASVLTNTLICLPFSDNWSIENQLKSAWNSYPSFCIQWGLNFSTDLLIFFYPFFLLKHLKLRRQQKIALIGVFSLGAITLIVSLSRFIAYNATNFELDDESGNTLSLAEMSTAVIVVCLPGLRRFIIRSKTSTNRSSSNQLSGYGVHTKITGVGQNDNTDKGQALSSQYAKWGVRDDEIELVTHIRVSHELVNPDDTRSASGQSAISQNVKVQGSQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFY1</accession>
    <name>C7ZFY1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_97340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698924">
        <property type="protein sequence ID" value="EEU37056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042769.1">
        <property type="nucleotide sequence ID" value="XM_003042723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFY1"/>
    <dbReference type="GeneID" id="9664967"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_97340"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_97340"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_2_1"/>
    <dbReference type="InParanoid" id="C7ZFY1"/>
    <dbReference type="OMA" id="KANEPFW"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF7">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="29"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU37056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="360" mass="40048" checksum="805B9E39BA314C74" modified="2009-10-13" version="1">MAPPTVRLPKSLLGRHRLLAPTAGVFVSPICLGTMNFGSVMNDSLGECTKETAFEILDYFYKQGGNFLDTASSYQGEESEKWLGEWLSKTGRRDEFQSNFGGNGSKSLHLSVEASLKKLQTTYIDLLYLHFWDMTTDIPEIMQSLNHLVSSGKVLYLGISDTPAWIVVKCNEYARQHGLRQFSVYQGRWSAADRDFERDIIPMCRAEGMGLAPWGTLGRGLFKPKDQIKVGGRNMPSMNNGREVLVSEKLEEIANDKGAPITSVALAYVLHKSPYVFPILGGRKLDHVRGNIEALGLRLTSQDIEDIETAYPFDVGFPHNFLSGNTNRGPRGPGDVRTANVRGLFDYVDDIHPILPSLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZGU5</accession>
    <name>C7ZGU5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyoxalase/fosfomycin resistance/dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_55706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698926">
        <property type="protein sequence ID" value="EEU36756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042469.1">
        <property type="nucleotide sequence ID" value="XM_003042423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZGU5"/>
    <dbReference type="GeneID" id="9669823"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55706"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55706"/>
    <dbReference type="eggNOG" id="ENOG502RMEJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052361_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZGU5"/>
    <dbReference type="OMA" id="CFFHIDR"/>
    <dbReference type="OrthoDB" id="3360610at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07267">
        <property type="entry name" value="THT_Oxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase/fosfomycin resistance/dioxygenase" evidence="1">
        <location>
            <begin position="159"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU36756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="274" mass="31637" checksum="AF03BD7D825157DE" modified="2009-10-13" version="1" fragment="single">SRILLDRLYYCRYGHPDLEKAKEFFTDFGLIPVQEKDDKVYFRGFGIDQFCYVAEKTSDGKRKFRGGAWIVQSMAELEKAAKLPGSTPIHDFDAPGGGKVVIIKDLLGEGVTLIYGQEDRVPEPREVPKPVMWNTWEDKKRLGDFQRPDRDLPSKVHKLGHYGFEVNVDKIHEVFDWYSKTFNMKKTDTLFQPQSKKTVMIFIHLDKGKEYVDHHNIFIAGSPELKEGIKAHHTSFEVDDVDSQVVGHHYLRRKGYINVFGVGRHVLGSQIFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZH61</accession>
    <name>C7ZH61_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_51810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698927">
        <property type="protein sequence ID" value="EEU36583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042296.1">
        <property type="nucleotide sequence ID" value="XM_003042250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZH61"/>
    <dbReference type="STRING" id="660122.C7ZH61"/>
    <dbReference type="GeneID" id="9669394"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51810"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51810"/>
    <dbReference type="eggNOG" id="KOG2820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_0_2_1"/>
    <dbReference type="InParanoid" id="C7ZH61"/>
    <dbReference type="OMA" id="QFMPLED"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF26">
        <property type="entry name" value="L-SACCHAROPINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="8"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="397"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU36583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="426" mass="47474" checksum="76927FBE62C5878F" modified="2009-10-13" version="1">MADTSRPVLILGGGCFGLATAYHLAQNGYSDITVLEKDHEVPSRFSAANDLNKVIRAEYADPFYTELALQAIRKWQTDPLYKPHYHETGFLNVGSNNAPDQTKRVLESYYASVRDNSAFNGKVQRVNGNADIKKLVPAFHHVQRWAGYFNKLAGYGHSANALSAVYAECVKLGVKFQLGSQKGEVESLLYASSRNGTKCVGAKTREGRIYLADKTIVALGADASNLIPRMGKQMTGRCWGVAHIQLTPKEADALRGIPVTNVRDLAFFFEPDKATNKLKFCHMGGAYTNYAWSQDGLSIPYSELSESQFIPEEDEVHIRRLLREVFPQLADRPLIDRHLCWFADTDDSDYIIDFVPGTDSSLVVLSGDSGHGFKMLPIFGQWVQKLLVEEKQSEPKWQWKTSKPKETAAWRSSGSQELASVARAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHY6</accession>
    <name>C7ZHY6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_86908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698929">
        <property type="protein sequence ID" value="EEU36361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042074.1">
        <property type="nucleotide sequence ID" value="XM_003042028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHY6"/>
    <dbReference type="STRING" id="660122.C7ZHY6"/>
    <dbReference type="GeneID" id="9669075"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86908"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86908"/>
    <dbReference type="eggNOG" id="ENOG502SPU6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004184_7_2_1"/>
    <dbReference type="InParanoid" id="C7ZHY6"/>
    <dbReference type="OMA" id="VECHIEE"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF82">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="51"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU36361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="670" mass="75816" checksum="3AFFECAEB56CE7A7" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHZ3</accession>
    <name>C7ZHZ3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Catalase-peroxidase</fullName>
            <shortName evidence="9">CP</shortName>
            <ecNumber evidence="9 10">1.11.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peroxidase/catalase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">katG</name>
        <name evidence="12" type="ORF">NECHADRAFT_52569</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 9 10">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9 10">
            <text>H2O2 + AH2 = A + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:30275"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="9">Binds 1 heme b (iron(II)-protoporphyrin IX) group per monomer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="9">Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the peroxidase family. Peroxidase/catalase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.21" evidence="9 10"/>
    <dbReference type="EMBL" id="GG698929">
        <property type="protein sequence ID" value="EEU36303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042016.1">
        <property type="nucleotide sequence ID" value="XM_003041970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHZ3"/>
    <dbReference type="STRING" id="660122.C7ZHZ3"/>
    <dbReference type="GeneID" id="9669079"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_52569"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_52569"/>
    <dbReference type="eggNOG" id="ENOG502QTDY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025424_2_0_1"/>
    <dbReference type="InParanoid" id="C7ZHZ3"/>
    <dbReference type="OMA" id="GPETTWL"/>
    <dbReference type="OrthoDB" id="407695at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00649">
        <property type="entry name" value="catalase_peroxidase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08200">
        <property type="entry name" value="catalase_peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000002">
        <property type="entry name" value="Catalase-peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000004">
        <property type="entry name" value="Catalase-peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01961">
        <property type="entry name" value="Catal_peroxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000763">
        <property type="entry name" value="Catalase_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00198">
        <property type="entry name" value="cat_per_HPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011635">
        <property type="entry name" value="PRK15061.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555:SF0">
        <property type="entry name" value="CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555">
        <property type="entry name" value="HYDROPEROXIDASE I, BIFUNCTIONAL CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00460">
        <property type="entry name" value="BPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9 10" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="5 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 9 10" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="11">
        <location>
            <begin position="113"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="cross-link" description="Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-94)" evidence="9">
        <location>
            <begin position="221"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU36303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="741" mass="81962" checksum="F4E1E7BF0CC8C0DB" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZI25</accession>
    <name>C7ZI25_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_29451</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698929">
        <property type="protein sequence ID" value="EEU36392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042105.1">
        <property type="nucleotide sequence ID" value="XM_003042059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZI25"/>
    <dbReference type="STRING" id="660122.C7ZI25"/>
    <dbReference type="GeneID" id="9669033"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_29451"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_29451"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000134_45_5_1"/>
    <dbReference type="InParanoid" id="C7ZI25"/>
    <dbReference type="OMA" id="CANDNRN"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="6"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU36392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="81" mass="8497" checksum="1519B580340767EA" modified="2009-10-13" version="1" fragment="single">HAQDAQGRTQLHRAALDGDVDQVRSLLEAGAAVNTQDVTGNTPLHSGVTGQNVEIVDLILRFGADADAINHLGRAPLHLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZI71</accession>
    <name>C7ZI71_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_86991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698929">
        <property type="protein sequence ID" value="EEU36406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042119.1">
        <property type="nucleotide sequence ID" value="XM_003042073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZI71"/>
    <dbReference type="GeneID" id="9669047"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86991"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86991"/>
    <dbReference type="eggNOG" id="ENOG502SPEI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072345_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZI71"/>
    <dbReference type="OMA" id="NIMCLCE"/>
    <dbReference type="OrthoDB" id="3678990at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU36406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="312" mass="35937" checksum="FBB0913869851A65" modified="2009-10-13" version="1">MASVVETHPSAPNLTNLISSYSILTTLSSWISTLDLYHLALTNRTHRSFILASPQIFKVLTRQSLCDGRGLADRQEFRGLYKIYDFDKGCGLIRRDEQVEVRLYNLKCDEAGALPCVKCGINVCEECRYYPRTSPAGKGRDPKRRPHLNASFQIGAIMCLCPSCDAAMENEVKGKFLNELCDCDALRYWICSKCRQEVDDFTGDYRGEHTAMEGEIEGFGPLPTKFIDDAGWIRAVWCMCGASVPRHTRMRCTWCKRRHLPESEWFDEFERIGSKMPWFDDDPDYPHWQTDDHGIYPIPYPRLGYKRPGDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJ89</accession>
    <name>C7ZJ89_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_85397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698932">
        <property type="protein sequence ID" value="EEU35972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041685.1">
        <property type="nucleotide sequence ID" value="XM_003041639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJ89"/>
    <dbReference type="GeneID" id="9674089"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85397"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85397"/>
    <dbReference type="HOGENOM" id="CLU_1682121_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZJ89"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU35972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="157" mass="17568" checksum="46C9C694E166D2E9" modified="2009-10-13" version="1" fragment="single">MSAACLACKTQHLKCVWGEGEQSRACRRSPKEDQTWVQCPRRLRFVDETQDVEAQYLSESPWQIGHQEISFADSPADLELAGADVDAELVNSSRELRLPPAAVSHDVPGHGVDCSFTTVPQSSLLGLANVEAGDVFPLTKPHEVRLMEYYRDYMCTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKA8</accession>
    <name>C7ZKA8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PI-PLC Y-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_14316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698938">
        <property type="protein sequence ID" value="EEU35494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041207.1">
        <property type="nucleotide sequence ID" value="XM_003041161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKA8"/>
    <dbReference type="STRING" id="660122.C7ZKA8"/>
    <dbReference type="GeneID" id="9675962"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_14316"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_14316"/>
    <dbReference type="eggNOG" id="KOG1516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_907812_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZKA8"/>
    <dbReference type="OMA" id="IICTTHE"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="1">
        <location>
            <begin position="111"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="307" mass="33609" checksum="D6FF548C4534A85B" modified="2009-10-13" version="1" fragment="single">SAALLAVSTNAQLWDKTIQTTYGPVKGFEYFNSSTTEKYFNTSTSSVTAYLGIPFAADTGYQNRWKPPQPHEPWNETLLATSFGPACPSPKNPTSSEDCLSLNIWTNANSSSDNLPVLVWNQGSGLSSDNPWWYGGGMAMRDVVFISFNRRDDAFGYLAHPDLNAEGLARDGFNTSGNYGVLDFLEVLKWVQGNIANFGGDLERVTIAGESFGSSQVYHAVNSELFSGLFSGAISQSGIRYPYDTLLAGLATSYVTMDDALFHGQNYTAFHNASSIAEMRELSMEELLVGSDVRLNGTWIWWVTALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKJ1</accession>
    <name>C7ZKJ1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_51180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698940">
        <property type="protein sequence ID" value="EEU35449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041162.1">
        <property type="nucleotide sequence ID" value="XM_003041116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKJ1"/>
    <dbReference type="STRING" id="660122.C7ZKJ1"/>
    <dbReference type="GeneID" id="9675692"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51180"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51180"/>
    <dbReference type="eggNOG" id="ENOG502RSHQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036110_1_3_1"/>
    <dbReference type="InParanoid" id="C7ZKJ1"/>
    <dbReference type="OMA" id="SPECNCI"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052988">
        <property type="entry name" value="Oryzine_lactonohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064:SF2">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="1">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="263" mass="29086" checksum="6FAEA6FC3F598E0E" modified="2009-10-13" version="1">MPWVWRTNLNHTPPVTEKVYPSPPLTMANGAYYHNGSVYWAQEGNWTVPGGIVRMNPLTLETEVVLNNFFGHRFNSPNDIIIKRNGVAFFTDGYYGYDNFNDTLKPELANGVWRWDMHTGSLRVVLGAGGGPFTNPNGVALNLDEDKLFITNRGNTSDNPAGGRTIYQYSISPTDTGLSDDRVFTYVDAGFPDGIKADSEGRIYGAVTGGVHVFDADGTFLGIIRVKTGDVAVNMQWVEDTLYIVGRGHLYRVNLNTTGSQMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKR9</accession>
    <name>C7ZKR9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_69908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698941">
        <property type="protein sequence ID" value="EEU35382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041095.1">
        <property type="nucleotide sequence ID" value="XM_003041049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKR9"/>
    <dbReference type="GeneID" id="9675577"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_69908"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_69908"/>
    <dbReference type="eggNOG" id="ENOG502SSH2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065434_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZKR9"/>
    <dbReference type="OMA" id="PSPHPWY"/>
    <dbReference type="OrthoDB" id="5352400at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="27413" checksum="69E0C72274729EBA" modified="2009-10-13" version="1">MAAPKVPLSLLMVEFTIALMAVILFGLAFPDRFRSRLWENGGEEGWNSNPNNIIYYYANHREPPESNLGIAILGFFIFFARALLSYSGFLYWYISAFYDILLLSLWSLSLTNQASSDFSDPEHPSPTPWYLTRNCSVAWDKNQGYCRIAQASFAVSILAAVLYGSRLLREAMLVAYERGRKHERQLSVQDFDEEMGNKYTDNEHKTAKGLMVLKESWQDVGLGPVLAFLESNYGGYWGIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLV7</accession>
    <name>C7ZLV7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_92359</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698947">
        <property type="protein sequence ID" value="EEU35031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040744.1">
        <property type="nucleotide sequence ID" value="XM_003040698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLV7"/>
    <dbReference type="FunCoup" id="C7ZLV7">
        <property type="interactions" value="1111"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZLV7"/>
    <dbReference type="GeneID" id="9679179"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_92359"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_92359"/>
    <dbReference type="eggNOG" id="KOG2171">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003794_0_1_1"/>
    <dbReference type="InParanoid" id="C7ZLV7"/>
    <dbReference type="OMA" id="PKRFVQE"/>
    <dbReference type="OrthoDB" id="543373at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007088">
        <property type="term" value="P:regulation of mitotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060188">
        <property type="term" value="P:regulation of protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041653">
        <property type="entry name" value="Importin_rep_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040928">
        <property type="entry name" value="Importin_rep_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041389">
        <property type="entry name" value="Importin_rep_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18808">
        <property type="entry name" value="Importin_rep_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18816">
        <property type="entry name" value="Importin_rep_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18829">
        <property type="entry name" value="Importin_rep_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="30"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU35031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1093" mass="121358" checksum="F35F832EA216201B" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZM82</accession>
    <name>C7ZM82_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_55049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698950">
        <property type="protein sequence ID" value="EEU34849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040562.1">
        <property type="nucleotide sequence ID" value="XM_003040516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZM82"/>
    <dbReference type="FunCoup" id="C7ZM82">
        <property type="interactions" value="246"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZM82"/>
    <dbReference type="GeneID" id="9679015"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55049"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55049"/>
    <dbReference type="eggNOG" id="KOG3035">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051989_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZM82"/>
    <dbReference type="OMA" id="KMQQFPG"/>
    <dbReference type="OrthoDB" id="671439at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd01838">
        <property type="entry name" value="Isoamyl_acetate_hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045136">
        <property type="entry name" value="Iah1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209:SF19">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="264" mass="28802" checksum="E49C877F808E25A1" modified="2009-10-13" version="1">MSVELTSETQFPYNQVVLFGDSLLELSCEVQDGFSFQAALQTLCMRRLDVINRGFSGYTTRNALNLLPKIFLPVSPSTPKIDCVVVLLGVNDACVSLPTTSQHVPLEEYKDNLTKIITHRHIVAHNPKILLVVPPPLDQIRITELDLEKGHAQASREAAVSSCYSEAAREVAQRVPGVVLVDLYKAIMDAAVSKTPDFDPTGPPLGFPGGKRGALAHLVPDGLHLSGEAYRIFYDLIQPHFGPFADTPDGYVFPDWLAVNPGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMU9</accession>
    <name>C7ZMU9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_34822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698959">
        <property type="protein sequence ID" value="EEU34630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040343.1">
        <property type="nucleotide sequence ID" value="XM_003040297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMU9"/>
    <dbReference type="GeneID" id="9678768"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_34822"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_34822"/>
    <dbReference type="eggNOG" id="ENOG502QWK1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038069_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZMU9"/>
    <dbReference type="OMA" id="VCSHNAS"/>
    <dbReference type="OrthoDB" id="5819478at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36851:SF1">
        <property type="entry name" value="GLYCO_TRANS_2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36851">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="488"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="60986" checksum="47B67EE59C3F5E49" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZND1</accession>
    <name>C7ZND1_FUSV7</name>
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        <recommendedName>
            <fullName evidence="3">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_55444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698966">
        <property type="protein sequence ID" value="EEU34473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040186.1">
        <property type="nucleotide sequence ID" value="XM_003040140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZND1"/>
    <dbReference type="GeneID" id="9678015"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55444"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55444"/>
    <dbReference type="eggNOG" id="ENOG502S00D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052989_0_1_1"/>
    <dbReference type="InParanoid" id="C7ZND1"/>
    <dbReference type="OMA" id="IWRLNIT"/>
    <dbReference type="OrthoDB" id="9977941at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052998">
        <property type="entry name" value="Hetero-Diels-Alderase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060:SF1">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU34473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="31197" checksum="1A1CD717A55FBF67" modified="2009-10-13" version="1">MQQQAAISTIFQLNSSGSWFENLAIRPDGQIIATRMDVPELWLINPITRKGRSLLTIPGVSGAIGISQQTSNTYIVGAGNVTADPFNFKPRSMKIFLLEFKGGYPDLKLVTELPEAMFINGITPWSKTEVLVSDTVLGAVYQIDIRKGSITSIMSDTDFAGINGIRVQNGFLYYASTSNQTFFRVPITKDFAIAGSVEIILSGIFMDDFALTPEGIAYIATVGRGEIIRVDPDGNAVTVGGAATSLDIAGGTSARLATSKGYGNILYVTTNGGLGAPVNGSVTEPAKVVAVKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNW7</accession>
    <name>C7ZNW7_FUSV7</name>
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        <recommendedName>
            <fullName evidence="3">Inner kinetochore subunit AME1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_50042</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039787.1">
        <property type="nucleotide sequence ID" value="XM_003039741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNW7"/>
    <dbReference type="STRING" id="660122.C7ZNW7"/>
    <dbReference type="GeneID" id="9677705"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_50042"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_50042"/>
    <dbReference type="eggNOG" id="ENOG502SGUR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019416_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZNW7"/>
    <dbReference type="OMA" id="SVMRIKG"/>
    <dbReference type="OrthoDB" id="5377952at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048743">
        <property type="entry name" value="AME1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20994">
        <property type="entry name" value="CENPU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inner kinetochore subunit AME1" evidence="3">
        <location>
            <begin position="473"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="544"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="391"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU34074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="666" mass="74074" checksum="B84BEEF1DAF075AA" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZP25</accession>
    <name>C7ZP25_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_63910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003039907.1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_63910"/>
    <dbReference type="eggNOG" id="KOG0269">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OMA" id="QTWRIVK"/>
    <dbReference type="OrthoDB" id="60955at2759"/>
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        <property type="component" value="Chromosome 10"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:vacuolar membrane"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of TORC1 signaling"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
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    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
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    <dbReference type="InterPro" id="IPR037590">
        <property type="entry name" value="WDR24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="259"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="430"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="475"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="675"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="765"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="803"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="906"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1214"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="477"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="690"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="719"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="830"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="914"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="927"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1214"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1232"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1242"/>
            <end position="1251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU34240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1301" mass="142322" checksum="1F915C03AE8A744B" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPP0</accession>
    <name>C7ZPP0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">6-phosphogluconate dehydrogenase NADP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_105483</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="EEU34171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003039838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZPP0"/>
    <dbReference type="STRING" id="660122.C7ZPP0"/>
    <dbReference type="GeneID" id="9677843"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_105483"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_105483"/>
    <dbReference type="eggNOG" id="KOG0409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035117_5_1_1"/>
    <dbReference type="InParanoid" id="C7ZPP0"/>
    <dbReference type="OMA" id="IFSCIAN"/>
    <dbReference type="OrthoDB" id="435038at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF3">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G11600)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="5">
        <location>
            <begin position="7"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="6">
        <location>
            <begin position="178"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU34171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="32363" checksum="8905B1210691497E" modified="2009-10-13" version="1">MAPTLLWIGLGNMGRGISKNIVEKGKLDGPLLLFNRSVQRAIDHSNSLPQGKSEVVTSLSEGISRADVIFSCVANDEAVQETYKTILEGDVKGKLFIESSTIHPDTTEALAKDVVAKGGEFVAAPIFGTPVMADAGLLIGVLAGPAASVTKAKMWFKGVTAVAEIDMSDEPYSKALKLKVLGNTFILNMVEQLAEAHVVAEKTGLGTDVLHQFVDSLFGGAYAACSAQMLSGDYHKKEPLFAVDLARKDAKHALSLAKDVGATLHNIETVDAHLTQLKEHAGPSVDMTGIYGAVRKEAGLKYETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPZ8</accession>
    <name>C7ZPZ8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PD-(D/E)XK nuclease-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_89043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698976">
        <property type="protein sequence ID" value="EEU33913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039626.1">
        <property type="nucleotide sequence ID" value="XM_003039580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZPZ8"/>
    <dbReference type="STRING" id="660122.C7ZPZ8"/>
    <dbReference type="GeneID" id="9667146"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89043"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89043"/>
    <dbReference type="eggNOG" id="ENOG502SSXD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027219_0_3_1"/>
    <dbReference type="InParanoid" id="C7ZPZ8"/>
    <dbReference type="OMA" id="QWNCAVH"/>
    <dbReference type="OrthoDB" id="4161186at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046797">
        <property type="entry name" value="PDDEXK_12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20516">
        <property type="entry name" value="PDDEXK_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PD-(D/E)XK nuclease-like" evidence="2">
        <location>
            <begin position="299"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU33913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="572" mass="63494" checksum="3348991E71BC3057" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQD5</accession>
    <name>C7ZQD5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_56076</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698988">
        <property type="protein sequence ID" value="EEU33782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039495.1">
        <property type="nucleotide sequence ID" value="XM_003039449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQD5"/>
    <dbReference type="STRING" id="660122.C7ZQD5"/>
    <dbReference type="GeneID" id="9667017"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_56076"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_56076"/>
    <dbReference type="eggNOG" id="KOG0257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_4_1"/>
    <dbReference type="InParanoid" id="C7ZQD5"/>
    <dbReference type="OMA" id="IMAARDY"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510:SF1">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="57"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU33782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="395" mass="43456" checksum="D8A3E2C3A1E66CA8" modified="2009-10-13" version="1">MVRIAPFAVEQYMGKYENTPGVINIAESCADSVSIDDLVRLSKDPQRSPINTGLKLTYGPVPGSQELRELVAAHCSYEATQLSADDVIISQGAIGANFLALYTLVHPGDHVICMYPTYQQLYDVPRAVGAEVSFWKLCAEEGFAYNIQDLKSLIRSNTKMIIINNPNSPTGIFIPTDDLEEIATLAKEKNIILFSDEVYRPLFHGGTSGQIDIPVPATTLGYERAVVTGSMSKGFALAGIRVGWIASRDKNIMEAIASARDYTTISVSQLDDQVASFALSPATRLPLVDRNISLARKNIKILKDFVQQHKSVCHWVEPKAGTTAFVHFSKNGEPVDDFKFCQDVLNKTQVYFCPGSYCFGGNKDFKGYVRIGYVGDTDVLVEGLKRLGAYVQENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQW4</accession>
    <name>C7ZQW4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_56446</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG699016">
        <property type="protein sequence ID" value="EEU33594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039307.1">
        <property type="nucleotide sequence ID" value="XM_003039261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQW4"/>
    <dbReference type="STRING" id="660122.C7ZQW4"/>
    <dbReference type="GeneID" id="9666829"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_56446"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_56446"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_2_1"/>
    <dbReference type="InParanoid" id="C7ZQW4"/>
    <dbReference type="OMA" id="EDAMESC"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="13"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU33594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="335" mass="35792" checksum="3C74958B50EAD7F6" modified="2009-10-13" version="1">MHSFTVYKGSQDGSIKKTTTEKTELTGDQVLVKVTASGLCGTDVHYRNQDMVLGHEGIGIVEATGPAVRQLKEGDRVGWGYEHDSCGLCELCQSGRETFCPSRSMYGFADLDQGSFASGAIWKESFLFKIPDGLTDAEAAPLMCAGATVFNALHMLDDAAIARVGVIGVGGLGHLAIQFAAKMGCDVAVFSGTDSKKAEAMKLGARTFYATKDKKGLDIGEKKLDILLVTSSSPPEWSLYIPLLSPGATIFPLTISFDNFSIPYPALVSMGLRVQGSMVAPRAIQKQMLEFAARNGVKPIVQAFPMTEKGIAEAFEALGSGKMRYRGVLIPGGRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQY9</accession>
    <name>C7ZQY9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Intradiol ring-cleavage dioxygenases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_89356</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG699020">
        <property type="protein sequence ID" value="EEU33565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039278.1">
        <property type="nucleotide sequence ID" value="XM_003039232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQY9"/>
    <dbReference type="GeneID" id="9666809"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89356"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89356"/>
    <dbReference type="eggNOG" id="ENOG502QWDJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046727_2_0_1"/>
    <dbReference type="InParanoid" id="C7ZQY9"/>
    <dbReference type="OMA" id="RCVMRSD"/>
    <dbReference type="OrthoDB" id="5238185at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF7">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catechol dioxygenase N-terminal" evidence="8">
        <location>
            <begin position="115"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="7">
        <location>
            <begin position="209"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU33565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="49078" checksum="A3572B36FA6BBB45" modified="2009-10-13" version="1">MSRAVRPYIFIYVKPAVSFGRSVLLKQRITRLAFPYYMSSHVVFLDNTHRAIPTSGGVARHPLLAHPTFRHIHNSPTAGVQVTISHTRPDIPPLKDLTTENITENVVAINSTCKDPRTRFLFERLAHHLHDFARETRLSTAEWEAAIQFLTSTGKIYSDTRQELILLSNILGLSLLVDSIDHPKPPTSTEGTILGPFHANGAENVASGETISHDPEGEPLLVVCSVRDSQGNPLTDIEVDVWETDSKGFYDMQYADREGFDNRAILHSDPQGKFHFKAIVPVLYPIPDDGPVGQLLKVLGRHPYRPSHIHFKFKKASYDPLITALYLRGDPYETSDAIFGVKESLVVDLTKVSKTPGFAEIYGVSGNTKLLQYDFILVSETEVAALRHAKALKSAGTLGTGLKPWPIRDLCAGRRAWGIVLENIDSKRHVYSIYKCPTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZR13</accession>
    <name>C7ZR13_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">OPT superfamily oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_105765</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="GG699023">
        <property type="protein sequence ID" value="EEU33548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039261.1">
        <property type="nucleotide sequence ID" value="XM_003039215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZR13"/>
    <dbReference type="GeneID" id="9666779"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_105765"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_105765"/>
    <dbReference type="eggNOG" id="KOG2262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004965_3_0_1"/>
    <dbReference type="InParanoid" id="C7ZR13"/>
    <dbReference type="OMA" id="VANMYFT"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="478"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="565"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="629"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="666"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="707"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU33548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="756" mass="84850" checksum="4D0F2CE12F8099A9" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-04-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>H6D5C0</accession>
    <name>H6D5C0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Small ribosomal protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rps3</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="1"/>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="2" last="14">
            <title>Comparative analysis of Fusarium mitochondrial genomes reveals a highly variable region that encodes an exceptionally large open reading frame.</title>
            <authorList>
                <person name="Al-Reedy R.M."/>
                <person name="Malireddy R."/>
                <person name="Dillman C.B."/>
                <person name="Kennell J.C."/>
            </authorList>
            <dbReference type="PubMed" id="22178648"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2011.11.008"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
            <strain evidence="1">MpVI</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JN041209">
        <property type="protein sequence ID" value="AEJ72888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H6D5C0"/>
    <dbReference type="STRING" id="660122.H6D5C0"/>
    <dbReference type="InParanoid" id="H6D5C0"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEJ72888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="511" mass="59333" checksum="86EFD7C7C4C8ED95" modified="2012-04-18" version="1">MKMKIYNNNLKRSSKTILLKKKINDVGITKYLPSYSKEWNNTIYSYNKNTLKNIPVNDLNINKIIKGYFNLYFKDRKYTGSKFILLKRRRNLLRRIHISNAEIKHTNNKAIITLYTINREKNVLKKKYLKINKKISKGLIAKRYFLLYKENIHKIYKILGKYKDQYIFINDIIRKKKFIKYKLQYLNKFIKLKDLYLKKVWGIILNKYARKYLKFLRKYDLLYSLNQYKFNKLVFLPILSNILNKIIGKKLEYNIINLKSVAYHTDLFTNALALKLKKRRINYINSMFSILNRAYLPNINTIKERSKIKGDQKMDNFQGKFKDLKIISSFRLLSKLSSEAHMNNNLSKLLDGAYPSNIKINNASLALMKLAAPPATKAVDEHSLLIPRISKLSDTSAVALASTAAKASQSDNFVAGGAQAIIHDIIYKSIGYKNMGGIRLEVKGRLTKRYRADRSIYSLKWKGGLKNIDSSFRGLSSVLFRGNSKSNVTYSIAKSKRRIGAFAVKGWIGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-04-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>H6D5D3</accession>
    <name>H6D5D3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="13">LAGLIDADG intron encoded protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">cox1-i2</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="13"/>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="2" last="14">
            <title>Comparative analysis of Fusarium mitochondrial genomes reveals a highly variable region that encodes an exceptionally large open reading frame.</title>
            <authorList>
                <person name="Al-Reedy R.M."/>
                <person name="Malireddy R."/>
                <person name="Dillman C.B."/>
                <person name="Kennell J.C."/>
            </authorList>
            <dbReference type="PubMed" id="22178648"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2011.11.008"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
            <strain evidence="13">MpVI</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the LAGLIDADG endonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="JN041209">
        <property type="protein sequence ID" value="AEJ72907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H6D5D3"/>
    <dbReference type="InParanoid" id="H6D5D3"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006314">
        <property type="term" value="P:intron homing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.28.10:FF:000007">
        <property type="entry name" value="Intron-encoded DNA endonuclease aI3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.28.10:FF:000011">
        <property type="entry name" value="Intron-encoded DNA endonuclease aI3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051289">
        <property type="entry name" value="LAGLIDADG_Endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36181">
        <property type="entry name" value="INTRON-ENCODED ENDONUCLEASE AI3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36181:SF6">
        <property type="entry name" value="INTRON-ENCODED LAGLIDADG ENDONUCLEASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00961">
        <property type="entry name" value="LAGLIDADG_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0404">Intron homing</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Homing endonuclease LAGLIDADG" evidence="12">
        <location>
            <begin position="33"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Homing endonuclease LAGLIDADG" evidence="12">
        <location>
            <begin position="153"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEJ72907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="302" mass="35268" checksum="A45C8DC456B56104" modified="2012-04-18" version="1" fragment="single">NKKGSPGGFRLRYNNTFNNIYIKELMYEVKSYLAGLFEGNGYIWIQDIAFNKKKQHNPRFCITFHIKNEPLAEKFKELIGSGYIRYKLQDSACNLVISPVIGLKKVVNLLNGELRTPKICQLYSLIDWLNKNHNSNITKLPLKNDYLYKDSWLSGFIDSDGSFFVQHTKVENGAKKRKISCRLRIEERILDPITKYSNMKILTDISNFLGCTLLTREQKSTGNRYYTLTASKTISLKTIINYLDKYPLLSSKILDYKAWKEIVLLIFKNKHYTEKGISKTEFVRSCMNTKRTHFSWDHLLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-04-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>H6D5E0</accession>
    <name>H6D5E0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">orf150</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="1"/>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="2" last="14">
            <title>Comparative analysis of Fusarium mitochondrial genomes reveals a highly variable region that encodes an exceptionally large open reading frame.</title>
            <authorList>
                <person name="Al-Reedy R.M."/>
                <person name="Malireddy R."/>
                <person name="Dillman C.B."/>
                <person name="Kennell J.C."/>
            </authorList>
            <dbReference type="PubMed" id="22178648"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2011.11.008"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
            <strain evidence="1">MpVI</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JN041209">
        <property type="protein sequence ID" value="AEJ72917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H6D5E0"/>
    <dbReference type="InParanoid" id="H6D5E0"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEJ72917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="150" mass="17009" checksum="193C1CD2D30A7100" modified="2012-04-18" version="1">MKNFTINLLFFYKDIDIPKPHAFVGLPLKSTIVELTEITLKVNELLPQLSDFISQFNNIILTSNINVITDAGGNMSLDVPGTMPDTDTERISRRISIIDRLITTRGQEINDLLQKGLTIEANLSKDNVNYTSQILDKVNEFKRLKASYKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7YGY6</accession>
    <name>C7YGY6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_57378</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054253.1">
        <property type="nucleotide sequence ID" value="XM_003054207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YGY6"/>
    <dbReference type="FunCoup" id="C7YGY6">
        <property type="interactions" value="312"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YGY6"/>
    <dbReference type="GeneID" id="9664334"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_57378"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_57378"/>
    <dbReference type="eggNOG" id="KOG0682">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_33_0_1"/>
    <dbReference type="InParanoid" id="C7YGY6"/>
    <dbReference type="OMA" id="NVMMKNM"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002229">
        <property type="entry name" value="RhesusRHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF10">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00342">
        <property type="entry name" value="RHESUSRHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="13"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU48540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="475" mass="51161" checksum="6B78FDC4E57FC3DE" modified="2009-10-13" version="1">MDVNIWYEPGDIAWMLASTALVLLMVPGVGFFYSGLARRKSALSLVWLSVMSASVTCFQWFFWGYSLTFSHTSGAFIGDLANFGFKDVLARPSVGSAHVPDMLFAVYQGMFSAMTVALATGAVAERGRMLPCVIFIFIWATIVYDPIACWTWNPNGWSNKMGVLDFAGGTPVHIASGSAALAYSMMLGKRRGHGTHELNYRPHNATHIVTGTVFLWVGWFGFNAGSALAANLRGVMAALVTNLAACVGGITWCLLDYRLERKFSTVGFCSGVVAGLVCITPGSGYVPPWAAVIFGVLGASGSNYATKVKFLLGIDDALDIFAVHGVGGLIGNICTAFFASPTIAALDGHSRINGGWTHHHWAQMGYQLADSFCGGLYSFSVTCLILFIMNLIPGLRLRVSEEAEVLGIDDAEIGEFAYDYVELTREVVNDVEGEAGSRYSADPTAFHPYEKHSIPMIDARMFGGQPPPAPLGFPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7YH84</accession>
    <name>C7YH84_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_98817</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable lipid hydrolase.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054301.1">
        <property type="nucleotide sequence ID" value="XM_003054255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YH84"/>
    <dbReference type="STRING" id="660122.C7YH84"/>
    <dbReference type="GeneID" id="9664457"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_98817"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98817"/>
    <dbReference type="eggNOG" id="KOG2214">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009031_5_0_1"/>
    <dbReference type="InParanoid" id="C7YH84"/>
    <dbReference type="OMA" id="SIVPWPH"/>
    <dbReference type="OrthoDB" id="10049244at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07229">
        <property type="entry name" value="Pat_TGL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF44">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="7">
        <location>
            <begin position="165"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="535"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU48588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="560" mass="62634" checksum="6358319E1EC50E28" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHY9</accession>
    <name>C7YHY9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_75135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054432.1">
        <property type="nucleotide sequence ID" value="XM_003054386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YHY9"/>
    <dbReference type="GeneID" id="9674659"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75135"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75135"/>
    <dbReference type="eggNOG" id="ENOG502RNNK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_631758_0_0_1"/>
    <dbReference type="InParanoid" id="C7YHY9"/>
    <dbReference type="OMA" id="EIHRVDW"/>
    <dbReference type="OrthoDB" id="5204927at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU48719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="434" mass="47538" checksum="A325BB62722E145D" modified="2009-10-13" version="1">MTTTMLYTTGASMDEPTNRFASKTNSSGKPRHRPKSIQIEPFDPNELSKKLTGLAVEQDGQPLQQNQLQVPMSANDMGEPSPRTIPAQQPAPATTSTAPKSHKDKKNDKLSTPTQAAPSRRSSIFDHLRFRGSNYTDETERQEEEDAKKKVRYRHVPQVAAQQFARTTTVEPLAQKAQPSPKGMRPVPGPHSMNNGSMSLQEYNRQYRRAQSLCSGRPSGPPGRTRLESTAEVDEENSQQKNPRISVQGWNDLKAGEPGRRMSTGNMWGRGDPQLQVPFRRDSTAVGAVCQNNPTSGRRGSASSSGFSDVSSPFARDSGPASPFKTEFGDANSPNRRGSDNTSTTASRRSSVANMANPQRAAEVHRVDWSQSDQPAKVRRDSKWAGLKQRKASVNQKTNNGEKLSPAGNVTEVQAQPSTSPKSPKAGFLGRFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJ71</accession>
    <name>C7YJ71_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_75577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053931.1">
        <property type="nucleotide sequence ID" value="XM_003053885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJ71"/>
    <dbReference type="GeneID" id="9663713"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75577"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75577"/>
    <dbReference type="eggNOG" id="KOG1812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_427639_0_0_1"/>
    <dbReference type="InParanoid" id="C7YJ71"/>
    <dbReference type="OMA" id="PRCCEPI"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU48218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="640" mass="74940" checksum="25B1E9B3F6E09782" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLY8</accession>
    <name>C7YLY8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="7">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_36534</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="7"/>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053073.1">
        <property type="nucleotide sequence ID" value="XM_003053027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YLY8"/>
    <dbReference type="STRING" id="660122.C7YLY8"/>
    <dbReference type="GeneID" id="9663914"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_36534"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_36534"/>
    <dbReference type="eggNOG" id="KOG0169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002738_3_0_1"/>
    <dbReference type="InParanoid" id="C7YLY8"/>
    <dbReference type="OMA" id="APCGFRE"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08598">
        <property type="entry name" value="PI-PLC1c_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000039">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF82">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="9">
        <location>
            <begin position="448"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="40"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="205"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="407"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="419"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU47360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="730" mass="81281" checksum="700BC83CD3C2E48C" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNR8</accession>
    <name>C7YNR8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_38914</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052337.1">
        <property type="nucleotide sequence ID" value="XM_003052291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNR8"/>
    <dbReference type="STRING" id="660122.C7YNR8"/>
    <dbReference type="GeneID" id="9670859"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_38914"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_38914"/>
    <dbReference type="eggNOG" id="ENOG502QRM1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042553_0_0_1"/>
    <dbReference type="InParanoid" id="C7YNR8"/>
    <dbReference type="OMA" id="WQNHTRD"/>
    <dbReference type="OrthoDB" id="4937900at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU46624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="497" mass="55494" checksum="576DD2F5975FA018" modified="2009-10-13" version="1">MAPPKERKRRFHRRSKNGCQTCKRRHVRCDEQKPLCTNCLQTGSECIYPTPEQTLPSNESSPSPSSSSSAAGPSTELEAFGNSQMTLAEPPAPGLINILNNYVGGSFDALPEPSKRLLQHFSQYTVWGQRPVARELESSAIQKSFENPGYMHMCLMLSACQWAWVTGSMDEVRIPFLYHKAATYQFAREQLQKPDTAQSGDTMLAISALALTEGAIGELDASSRHLKGIRSAVEQWNRDADQVPTLPQRMLKMVGDGLRTGKSGQLVNVPEYQPTFMALLFASIWDITALPPREAPRYGWWEDTDSRAARLWQNHTKDLNLNYEISRGFNPTQYVPRILNGDPKSSRTSFIATFFYLCSELGHKYFDVTLIDWLLEQLIDDVNAGEAHLKTSVWTQALWLWCVMFGAAIASTGRASNMVEERQLAKWRGVYSDKMKLFSRELGINSWQAAKAMLAGVLGRIEGEIERGLEELWNEGIAGGVTGESSASPAVIELDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQA1</accession>
    <name>C7YQA1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GRF-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_79032</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051698.1">
        <property type="nucleotide sequence ID" value="XM_003051652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQA1"/>
    <dbReference type="GeneID" id="9673452"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79032"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79032"/>
    <dbReference type="eggNOG" id="ENOG502SYR7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037645_1_0_1"/>
    <dbReference type="InParanoid" id="C7YQA1"/>
    <dbReference type="OMA" id="WFWTCAQ"/>
    <dbReference type="OrthoDB" id="430051at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="6">
        <location>
            <begin position="39"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="83"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU45985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="378" mass="42229" checksum="84F30555AA0DC7E3" modified="2009-10-13" version="1">MVSTPRAKSRYQSTQQPETPRSVKKRLHKGRFSDGHWWCNCEPRNKASLRETRKSGPNKGRFYWKCDDCSFFLWWDEAKSRETGLKSSEKGESSRSKAPALTQQSLVSYGYQVTPSRRDSNTDFEDSTESGEESEQDPPMPKSAKTAEAGPSRAAALETPSRGPTKRKRDVFEDDEDEDEFSDLGSDEERQMVAIADKSVEKAAAQRRYETPTNMRSADVISGLPTPVSRTLFPGTDSKRQKQVSFEDTPSRPSVALSSATISAGTTPSRTPAGLQAVPSSSPPDNSYDVTDEIMGLLQDQKVDPSVLRAIKHTLTTAARRTKGIILGRDSARATLKIRDEKIASLQERITALENRERMHHSQMTNIKANLMKMYDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQD0</accession>
    <name>C7YQD0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_68385</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052159.1">
        <property type="nucleotide sequence ID" value="XM_003052113.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="C7YQD0">
        <property type="interactions" value="58"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YQD0"/>
    <dbReference type="GeneID" id="9673537"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_68385"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_68385"/>
    <dbReference type="eggNOG" id="KOG0955">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001514_0_0_1"/>
    <dbReference type="InParanoid" id="C7YQD0"/>
    <dbReference type="OMA" id="WVMDEPP"/>
    <dbReference type="OrthoDB" id="336088at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048189">
        <property type="term" value="C:Lid2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036205">
        <property type="term" value="P:histone catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.490:FF:000018">
        <property type="entry name" value="Lid2 complex component snt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000899">
        <property type="entry name" value="PHD finger and BAH domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
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            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1554" mass="171665" checksum="27D1FF1CB3996962" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQY7</accession>
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        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="3" type="ORF">NECHADRAFT_79271</name>
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            <taxon>Sordariomycetes</taxon>
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        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
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            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
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</entry>
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        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
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                <person name="Grimwood J."/>
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                <person name="Taga M."/>
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                <person name="Zhou S."/>
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                <person name="Freitag M."/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="WD40_rpt"/>
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    <dbReference type="InterPro" id="IPR051858">
        <property type="entry name" value="WD_repeat_GAD-1"/>
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        <property type="entry name" value="GASTRULATION DEFECTIVE PROTEIN 1-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 70"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="99"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="211"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="478"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="547"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU46107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="583" mass="63726" checksum="094C6D9C04728939" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7YR34</accession>
    <name>C7YR34_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_92893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051842.1">
        <property type="nucleotide sequence ID" value="XM_003051796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YR34"/>
    <dbReference type="STRING" id="660122.C7YR34"/>
    <dbReference type="GeneID" id="9673741"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_92893"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_92893"/>
    <dbReference type="eggNOG" id="ENOG502RXR7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025640_2_1_1"/>
    <dbReference type="InParanoid" id="C7YR34"/>
    <dbReference type="OMA" id="RLPWEWY"/>
    <dbReference type="OrthoDB" id="5422510at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032:SF1">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
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            <begin position="167"/>
            <end position="212"/>
        </location>
    </feature>
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        <location>
            <begin position="449"/>
            <end position="485"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU46129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="485" mass="52855" checksum="4AE5C66CC40DE19B" modified="2009-10-13" version="1">MTDENTTSTNGWRPGTGVSSAVSAAPPSGHGLRRAMTVSVAEDAAAARRASASSFPAMDTMPPRRSSNFSEYSLSEARDILNPQPRGPGSADTFSSPGDSSSLASLSLAFALLPALAGVLFKNGSAVVTDVMLLGLAGVFLHWSVTQPWAWYHSAQEVRIQREATAESVIEDDSDLDSSPNMPAHSSPLDHVPEDEETQPESHEDLRERHPTTQQQSALAELYVYEIIALASCFALPLIGAYLLHAIRSQLSRPSEGLVSNYNLTIFLLVSELRVLSHMIKLLQSRTLHLQRIVQGSPSSIQSTRNAEQLEAVLARLDRLECRITAEDIISTQGSRQESSRSKQQDNAVARDVRNAIQPELDALNRAVRRYEKKATLLQFQTESRFSGVESKLDDAIALAASAAKNSASHKNIFLWAIESLTALVLLPFKALLRILLLPLSTLLALTSKSKRKAPTSKSSRGRNGKAAMQPRYNGDRVPTRVSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7YR84</accession>
    <name>C7YR84_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glutamine synthetase</fullName>
            <ecNumber evidence="3 11">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_61028</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3 11"/>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051123.1">
        <property type="nucleotide sequence ID" value="XM_003051077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YR84"/>
    <dbReference type="FunCoup" id="C7YR84">
        <property type="interactions" value="780"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YR84"/>
    <dbReference type="GeneID" id="9666517"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_61028"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_61028"/>
    <dbReference type="eggNOG" id="KOG0683">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036762_1_1_1"/>
    <dbReference type="InParanoid" id="C7YR84"/>
    <dbReference type="OMA" id="DRRPNAN"/>
    <dbReference type="OrthoDB" id="1936100at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019676">
        <property type="term" value="P:ammonia assimilation cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF57">
        <property type="entry name" value="GLUTAMINE SYNTHETASE 2 CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="12">
        <location>
            <begin position="26"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="13">
        <location>
            <begin position="112"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU45410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="356" mass="39788" checksum="95505E5914EED63C" modified="2009-10-13" version="1">MATSAPTTSRTETLAKYLKLDQKGQIMAEYVWVDADGETRSKSRTLPEKEYKPEDLPVWNFDGSSTRQAPGDNSDVYLRPCAVYPDPFRGSPNIIVLAECWNADGTPNKYNYRHDCVKVMDTYADDEPWFGLEQEYTLLGLDNRPYGWPSGGFPAPQGEYYCGVGTGKVVQRDIVEAHYKACLYAGIKISGTNAEVMPAQWEYQVGPCLGIEMGDMLWVSRFFLARISEEFGAKVSLHPKPIAGDWNGAGLHSNFSTKAMREEGGMKVIEEALKKLEPHHAECIAEYGEDNDQRLTGRHETGSIDSFSWGVANRGTSIRVPRETAAKGYGYFEDRRPASNADPYRVTKVLLQFSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7YS31</accession>
    <name>C7YS31_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_100629</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051280.1">
        <property type="nucleotide sequence ID" value="XM_003051234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YS31"/>
    <dbReference type="STRING" id="660122.C7YS31"/>
    <dbReference type="GeneID" id="9666057"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100629"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100629"/>
    <dbReference type="eggNOG" id="ENOG502SFDE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063084_4_2_1"/>
    <dbReference type="InParanoid" id="C7YS31"/>
    <dbReference type="OMA" id="INCIVDG"/>
    <dbReference type="OrthoDB" id="3767534at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012384148" description="CFEM domain-containing protein" evidence="11">
        <location>
            <begin position="16"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="12">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU45567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="138" mass="14134" checksum="17756B6948D91122" modified="2009-10-13" version="1">MRFLFFTTLVTSALAIDSLTELMDQLPKCSIDCLTNALSEQGCSLTDVQCACSNVQAIVESASPCLIIAGCDLDELSNAATSVADICKGQTTRTPTPAASSAPTSTTADTVETNGQPSTFGKGSMWTGAFAAAAVALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSC2</accession>
    <name>C7YSC2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_40555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051323.1">
        <property type="nucleotide sequence ID" value="XM_003051277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSC2"/>
    <dbReference type="FunCoup" id="C7YSC2">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YSC2"/>
    <dbReference type="GeneID" id="9666180"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_40555"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_40555"/>
    <dbReference type="eggNOG" id="ENOG502QPV0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026648_0_0_1"/>
    <dbReference type="InParanoid" id="C7YSC2"/>
    <dbReference type="OMA" id="KQDRTTY"/>
    <dbReference type="OrthoDB" id="2011986at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018810">
        <property type="entry name" value="UPF0662"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086:SF1">
        <property type="entry name" value="CU(2+) SUPPRESSING AND BLEOMYCIN SENSITIVE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086">
        <property type="entry name" value="UPF0662 PROTEIN YPL260W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10303">
        <property type="entry name" value="DUF2408"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU45610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="477" mass="54717" checksum="D6599AE7183253AD" modified="2009-10-13" version="1">MDTPAIPLPRDPRERAILDKLIMTRDHLLLLKQDRTNYIRTQDVMPLFDQTMDQVKELTVVRAETGDSEENRLDKVLESCFQLLSLFYLTIGRNNEAPATYALTSTIKRLLDHLVESDVYSAKDLGSIKSTLEDLCNSIRDAANDESPDKRHPPYMLTLLSNRIKLCNSTLEKLQKRLERVPQSLLETHEKLVSILRSISLANTKSKFSSNEVKKLRNQILEIGESHNGGKFTAEDGSLVEGSEEVRDLYNRCLRWSDLVLERQVELRLVERYVQGEVADQWRPVYTELLQIRNNLEKLSLTQAWSLRETDLYDFQRQLDRIDESRDAGNWLDDRGRTADLWTQRTLLYLIRRSYAYIYSFMLASEPVSEALLPVYNQLQTLKRCLVEVKKNGGVSSVRELYPYSMKLNSLDNMKVDGKFVVNGDVPEGQGSVSELLAECFDLNYELRVAAEEAAENGNGKADGHVEAREVEESKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSF4</accession>
    <name>C7YSF4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_80717</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051339.1">
        <property type="nucleotide sequence ID" value="XM_003051293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSF4"/>
    <dbReference type="STRING" id="660122.C7YSF4"/>
    <dbReference type="GeneID" id="9668186"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_80717"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_80717"/>
    <dbReference type="eggNOG" id="KOG3872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021864_0_0_1"/>
    <dbReference type="InParanoid" id="C7YSF4"/>
    <dbReference type="OMA" id="VEHAGFM"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000127">
        <property type="entry name" value="Uncharacterized protein C3H7.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051176">
        <property type="entry name" value="Cent_Immune-Sig_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715:SF46">
        <property type="entry name" value="TO VACUOLE TARGETING VPS64, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="711"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="182"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU45626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="742" mass="81188" checksum="814763512C8AAFE5" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSH4</accession>
    <name>C7YSH4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_80737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050960.1">
        <property type="nucleotide sequence ID" value="XM_003050914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSH4"/>
    <dbReference type="STRING" id="660122.C7YSH4"/>
    <dbReference type="GeneID" id="9668275"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_80737"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_80737"/>
    <dbReference type="eggNOG" id="ENOG502QTW7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_288215_0_0_1"/>
    <dbReference type="InParanoid" id="C7YSH4"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="459"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU45247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1067" mass="121288" checksum="0D34C4150BC7120B" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSX6</accession>
    <name>C7YSX6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucose 1-dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_100707</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
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        <property type="protein sequence ID" value="EEU45313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003050980.1"/>
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    <dbReference type="AlphaFoldDB" id="C7YSX6"/>
    <dbReference type="GeneID" id="9668437"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100707"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100707"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="InParanoid" id="C7YSX6"/>
    <dbReference type="OMA" id="YMTGTDF"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF63">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU45313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="30887" checksum="17D8980260C84F94" modified="2009-10-13" version="1">MPAVTDSQTRGRLAGKNAIITGAAGGIGLETSILFAKEGASVLLSDISQPALEKAAAKVKQLVPNAPRVEIFKCDVSKEAEVKAMVETLDSWGGLDVMFNNAGIMHAQDDDAVNTPENIWDLTHNINVKGVWFGCKHAVLSLRRHQKTKASIINTASVVALVGAATPQLAYTASKGAVLALTRELAMVHAREGYRFNNLCPAPLNTPLLQDWLGDDKEKRHRREVHFPMGRFGEAVEQAHAVVFLASDESSFVNGHDFAVDGGMTKAYVTAEGPANPPPQNNALKDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7YT62</accession>
    <name>C7YT62_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_41510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051068.1">
        <property type="nucleotide sequence ID" value="XM_003051022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YT62"/>
    <dbReference type="GeneID" id="9666463"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_41510"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_41510"/>
    <dbReference type="eggNOG" id="ENOG502SI9D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006926_3_0_1"/>
    <dbReference type="InParanoid" id="C7YT62"/>
    <dbReference type="OMA" id="THMQEFY"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="359"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU45355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="683" mass="75960" checksum="6CD6956EC30ED9DE" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7YT91</accession>
    <name>C7YT91_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose 1-dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_41350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051087.1">
        <property type="nucleotide sequence ID" value="XM_003051041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YT91"/>
    <dbReference type="STRING" id="660122.C7YT91"/>
    <dbReference type="GeneID" id="9666481"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_41350"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_41350"/>
    <dbReference type="eggNOG" id="KOG1200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="InParanoid" id="C7YT91"/>
    <dbReference type="OMA" id="WEVANVI"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000417">
        <property type="entry name" value="Glucose 1-dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF83">
        <property type="entry name" value="(3R)-3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0684">Rhamnose metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU45374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="28644" checksum="B99720022EE7E5CD" modified="2009-10-13" version="1">MLMPAGLLVNKSAIITGGTTGIGRAICLEFLRQGANVVVNHLGLEKDQKHLDSLIAEADAIRKATPTAGRLAHQEGDVRNPDTATNLVKMAVEHSGPSKRLDVCVSNAGICTFADFLTLESDLLYKTVRTNLDGAFYVTQAAARQMALNQTPKGGSIIGVSSISALVGGGQQTHYTPTKAGVLSLMQSTACALGEHNIRCNALLPGTIRTQLNDADLADDNKRAYMEGRIPLGRTGSPSDMAGPAVFLACPELSGYVTGAQLLVDGGLFVNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7YU01</accession>
    <name>C7YU01_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar protein sorting-associated protein 68</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_102821</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0220 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050428.1">
        <property type="nucleotide sequence ID" value="XM_003050382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YU01"/>
    <dbReference type="FunCoup" id="C7YU01">
        <property type="interactions" value="203"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YU01"/>
    <dbReference type="GeneID" id="9674827"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102821"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102821"/>
    <dbReference type="eggNOG" id="KOG3393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096876_0_0_1"/>
    <dbReference type="InParanoid" id="C7YU01"/>
    <dbReference type="OMA" id="VHITFVD"/>
    <dbReference type="OrthoDB" id="268928at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007919">
        <property type="entry name" value="UPF0220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13180">
        <property type="entry name" value="SMALL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05255">
        <property type="entry name" value="UPF0220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU44715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="18687" checksum="11990AC929505A75" modified="2009-10-13" version="1">MEEERLWKFRKPEWLNSVWARNAGVYAAGAIFSVAFYVMLDSAVWSKSPRNGSDVHVKFVDWLPFVFSSLGMLIINSVEKQRLSADSFSYSGSGVAWKARVVLFLGFAALAGGMAGGVTVFVLKFVVPSVAMPALGMGIENVVSNALVGVSSVVLWVSQNMEDEYSYNLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7YU82</accession>
    <name>C7YU82_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Small nuclear ribonucleoprotein Sm D2</fullName>
            <shortName evidence="12">Sm-D2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 12">snRNP core protein D2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_84833</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050081.1">
        <property type="nucleotide sequence ID" value="XM_003050035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YU82"/>
    <dbReference type="FunCoup" id="C7YU82">
        <property type="interactions" value="1154"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YU82"/>
    <dbReference type="GeneID" id="9665443"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84833"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84833"/>
    <dbReference type="eggNOG" id="KOG3459">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_2_1_1"/>
    <dbReference type="InParanoid" id="C7YU82"/>
    <dbReference type="OMA" id="DVKEMWT"/>
    <dbReference type="OrthoDB" id="437526at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01720">
        <property type="entry name" value="Sm_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000018">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027248">
        <property type="entry name" value="Sm_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12777">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="35"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU44368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="117" mass="13471" checksum="41AE898F1C03D82A" modified="2009-10-13" version="1">MSDPKIQELLTKPRSDLTEYEIAQLEEHEFSAGPLSILQTAVRSHIQVLISIRNNRKLLARVKAFDRHCNMVLENVKEMWTETPRLANGKKGRPVNKDRFISKMFLRGDSVILVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVW7</accession>
    <name>C7YVW7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_89645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049786.1">
        <property type="nucleotide sequence ID" value="XM_003049740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVW7"/>
    <dbReference type="STRING" id="660122.C7YVW7"/>
    <dbReference type="GeneID" id="9677361"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89645"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89645"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_3_3_1"/>
    <dbReference type="InParanoid" id="C7YVW7"/>
    <dbReference type="OMA" id="PRKMLFI"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="91"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU44073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="294" mass="32651" checksum="A12DB61790045634" modified="2009-10-13" version="1">MVSIILHHLHAWFRPTLAALFQRNLPWSYRWRLLVFQPVILLTYSIATIPCLLYRPFTVEYLPIAPGRYVRALIFKAAGVGKGRAKRPLHVNFHAGAFIGGLPEGHARFDDRVAKETGAVVVDVDYRVAPEHVFPAAIDDADATIKWLQEHAEERWGADATLMTTSGFSAGGNIALAATQQETCHAPWPTAIKAVTNFYGAIDLRLSPWEKPHPPTMPKNDPARVFVPLFDAYAGPARAKHFEDPRLSPVLAKKETLPDRILLVVPGIDILVAEQTEFAERVNAEDEASYSMGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVY8</accession>
    <name>C7YVY8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent RNA helicase DOB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_89658</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU43872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049585.1">
        <property type="nucleotide sequence ID" value="XM_003049539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVY8"/>
    <dbReference type="FunCoup" id="C7YVY8">
        <property type="interactions" value="1146"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YVY8"/>
    <dbReference type="GeneID" id="9677371"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89658"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89658"/>
    <dbReference type="eggNOG" id="KOG0948">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002902_0_1_1"/>
    <dbReference type="InParanoid" id="C7YVY8"/>
    <dbReference type="OMA" id="IMLKNYN"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18024">
        <property type="entry name" value="DEXHc_Mtr4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13154">
        <property type="entry name" value="KOW_Mtr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000003">
        <property type="entry name" value="ATP dependent RNA helicase (Dob1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000083">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000141">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.300:FF:000001">
        <property type="entry name" value="Mtr4 exosome RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="164"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="400"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="368"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU43872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1090" mass="123583" checksum="FD752AAE5A988497" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7YW21</accession>
    <name>C7YW21_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_30050</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049811.1">
        <property type="nucleotide sequence ID" value="XM_003049765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YW21"/>
    <dbReference type="ESTHER" id="nech7-c7yw21">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="9677386"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_30050"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_30050"/>
    <dbReference type="eggNOG" id="KOG4389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_10_6_1"/>
    <dbReference type="InParanoid" id="C7YW21"/>
    <dbReference type="OMA" id="NNWYPQF"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000213">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005125773" description="Carboxylic ester hydrolase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="9">
        <location>
            <begin position="53"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU44098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="587" mass="63062" checksum="0574D6E40B160DC3" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7YW78</accession>
    <name>C7YW78_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Vacuolar protein sorting-associated protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_102969</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the VPS29 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU43916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049629.1">
        <property type="nucleotide sequence ID" value="XM_003049583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YW78"/>
    <dbReference type="FunCoup" id="C7YW78">
        <property type="interactions" value="1083"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YW78"/>
    <dbReference type="GeneID" id="9677417"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102969"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102969"/>
    <dbReference type="eggNOG" id="KOG3325">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063749_0_1_1"/>
    <dbReference type="InParanoid" id="C7YW78"/>
    <dbReference type="OMA" id="VRGNMDY"/>
    <dbReference type="OrthoDB" id="10258130at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07394">
        <property type="entry name" value="MPP_Vps29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000024">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028661">
        <property type="entry name" value="Vps29"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN VPS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU43916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="201" mass="22056" checksum="3750DDFDC496387E" modified="2009-10-13" version="1">MAFLILVIGDLHIPDRALDIPAKFKKLLAPGKIGQTLCLGNLTDKHTYEYLRSISPDLKIVKGRYDVEATSLPLTQVVTHGSLRIGFLEGFTLVSNEPDLLLAEANKLDVDVLCWGGTHRFDAFEYMDKFFVNPGSATGAFPGSWGKDGEEPTPSFCLMDVQGISLTLYVYQLRKDDKGNENVAVEKVTYTKPVEPSGGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWX7</accession>
    <name>C7YWX7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_95032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049200.1">
        <property type="nucleotide sequence ID" value="XM_003049154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWX7"/>
    <dbReference type="GeneID" id="9666577"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95032"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95032"/>
    <dbReference type="eggNOG" id="ENOG502QU9Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030671_1_1_1"/>
    <dbReference type="InParanoid" id="C7YWX7"/>
    <dbReference type="OMA" id="QVWVGKP"/>
    <dbReference type="OrthoDB" id="5396at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF8">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU43487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="36210" checksum="31EC72C9819060F9" modified="2009-10-13" version="1">MDPSYMEKSWDELPNPKRVWVGEPGSREEGLGRLVLLTPERVAAAAKQIRTGIRVNLGWDLQKLEYACFNRQPCEFKVVPILGGVAFDDIYVMNPQQSSQWDGLRHFSTPIEGGSSERVFYGGTTKEEILDRSNGRIGIQHWAREGITGRGVLIDYASWAEKKGVKYTTFSLHAIKLTDILEIAQECNITFQRGDILFVRTGVIKEWEKDMDVEAKKAYASSTNPQHAGVEGTLDVLKWVWNTGFAAVAGDAISWEVYPPPPGTILMHEYMLAGWGMPIGELFDLERLAETCKELNRWTFFVSSSPFNMKGGISSPPNAQAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXS8</accession>
    <name>C7YXS8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_82635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049109.1">
        <property type="nucleotide sequence ID" value="XM_003049063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXS8"/>
    <dbReference type="GeneID" id="9666408"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82635"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82635"/>
    <dbReference type="HOGENOM" id="CLU_894550_0_0_1"/>
    <dbReference type="InParanoid" id="C7YXS8"/>
    <dbReference type="OrthoDB" id="5077032at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU43396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="33677" checksum="D2F50AA135FB996C" modified="2009-10-13" version="1">MAVLLQPQKREGPSADDSTFWSEFLETRTEMASLIPTARPKAEETLVGSYMNSGGTVQSFMCREDSSFWTGLRVAGDTRTFARCDKSWEWIATECNDNGYVQFTNVIENTSGTNSCGGDYCTTLTIYDSNAEDEKGAQYMIDCKTFLQAPGSNNPYTRFYREYRTDLTTTDSSTATEAPATTHDSTMAGLATSSASSETGGPGNNDGANGLSSGAIAGIVVGTIAGLCLVACGFYIAYRIGRKRRNDAEKSDRGFMGLQQKFVGDDIQGPREMLGDTKQSAPVVELPAEHLAEMEAPVDNRPISRRTGAQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXX8</accession>
    <name>C7YXX8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_82685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049384.1">
        <property type="nucleotide sequence ID" value="XM_003049338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXX8"/>
    <dbReference type="GeneID" id="9677019"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82685"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82685"/>
    <dbReference type="HOGENOM" id="CLU_943623_0_0_1"/>
    <dbReference type="InParanoid" id="C7YXX8"/>
    <dbReference type="OrthoDB" id="5085482at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU43671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="295" mass="32735" checksum="23FAEE9A92CCE6F6" modified="2009-10-13" version="1">MTSIARTFMGFTPALMNKAKSDMQGTTQSALSVAVLIIPSRRMRQGSAGEIKEQPKHAARNQRHEPSLAVVFIRPEQLSMPTYPTTIVGKRERQRAPKLSSNAEMPQNLVEEAEGKEFPERVSHEKDICALGNSFLAVLNVVALILASLAYSQNKSKKPAELALCVLNDETGIFVPPIFASVWLIISIKRNDRRAVAKLIFVAVVVAFYCLLSFGFGVAFAKRFIKNEEWGPKITFRIASTVINLVNVLVGFVILWFHQRLGAAIPSYPVTPVIASNFVFFEKSFVEKPSSRPDL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-04-05" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZ74</accession>
    <name>ARO1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pentafunctional AROM polypeptide</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="1">3-dehydroquinate synthase</fullName>
                <shortName evidence="1">DHQS</shortName>
                <ecNumber evidence="1">4.2.3.4</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
                <ecNumber evidence="1">2.5.1.19</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
                <shortName evidence="1">EPSP synthase</shortName>
                <shortName evidence="1">EPSPS</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">Shikimate kinase</fullName>
                <shortName evidence="1">SK</shortName>
                <ecNumber evidence="1">2.7.1.71</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">3-dehydroquinate dehydratase</fullName>
                <shortName evidence="1">3-dehydroquinase</shortName>
                <ecNumber evidence="1">4.2.1.10</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">Shikimate dehydrogenase</fullName>
                <ecNumber evidence="1">1.1.1.25</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name type="ORF">NECHADRAFT_47780</name>
    </gene>
    <organism>
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>shikimate + NADP(+) = 3-dehydroshikimate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>shikimate + ATP = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text>Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the 2nd section; belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the 3rd section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the 4th section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="1"/>
    <dbReference type="EC" id="2.5.1.19" evidence="1"/>
    <dbReference type="EC" id="2.7.1.71" evidence="1"/>
    <dbReference type="EC" id="4.2.1.10" evidence="1"/>
    <dbReference type="EC" id="1.1.1.25" evidence="1"/>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048265.1">
        <property type="nucleotide sequence ID" value="XM_003048219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZ74"/>
    <dbReference type="SMR" id="C7YZ74"/>
    <dbReference type="FunCoup" id="C7YZ74">
        <property type="interactions" value="472"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YZ74"/>
    <dbReference type="EnsemblFungi" id="NechaT47780">
        <property type="protein sequence ID" value="NechaP47780"/>
        <property type="gene ID" value="NechaG47780"/>
    </dbReference>
    <dbReference type="GeneID" id="9667391"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_47780"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_47780"/>
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        <property type="entry name" value="SHIKIMATE_KINASE"/>
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    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
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    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
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            <position position="1170"/>
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            <position position="1198"/>
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        <location>
            <begin position="49"/>
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        <ligand>
            <name>NAD(+)</name>
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    <feature type="binding site" evidence="1">
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            <begin position="84"/>
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        <ligand>
            <name>NAD(+)</name>
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    <feature type="binding site" evidence="1">
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        <ligand>
            <name>NAD(+)</name>
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    <feature type="binding site" evidence="1">
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            <position position="120"/>
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        <ligand>
            <name>NAD(+)</name>
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    <feature type="binding site" evidence="1">
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        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
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        <location>
            <begin position="140"/>
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        <ligand>
            <name>NAD(+)</name>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="147"/>
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        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
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        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="162"/>
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        <ligand>
            <name>NAD(+)</name>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="163"/>
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        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
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        </ligand>
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    <feature type="binding site" evidence="1">
        <location>
            <begin position="180"/>
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        <ligand>
            <name>NAD(+)</name>
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    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="191"/>
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        <ligand>
            <name>NAD(+)</name>
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    <feature type="binding site" evidence="1">
        <location>
            <begin position="195"/>
            <end position="198"/>
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        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
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        </ligand>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="195"/>
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        <ligand>
            <name>Zn(2+)</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="248"/>
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        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
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        </ligand>
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    <feature type="binding site" evidence="1">
        <location>
            <begin position="262"/>
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        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
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    <feature type="binding site" evidence="1">
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            <position position="269"/>
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        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
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    <feature type="binding site" evidence="1">
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            <position position="269"/>
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        <ligand>
            <name>Zn(2+)</name>
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        </ligand>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="285"/>
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        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
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    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="285"/>
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        <ligand>
            <name>Zn(2+)</name>
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        </ligand>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="354"/>
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        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="866"/>
            <end position="873"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03143"/>
        </source>
    </evidence>
    <sequence length="1569" mass="169799" checksum="8FAD1A4AA80AC0ED" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZB9</accession>
    <name>C7YZB9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">INO80 complex subunit B-like conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_83976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048287.1">
        <property type="nucleotide sequence ID" value="XM_003048241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZB9"/>
    <dbReference type="STRING" id="660122.C7YZB9"/>
    <dbReference type="GeneID" id="9667569"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83976"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83976"/>
    <dbReference type="eggNOG" id="ENOG502S7M7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036529_1_0_1"/>
    <dbReference type="InParanoid" id="C7YZB9"/>
    <dbReference type="OMA" id="VHARWAD"/>
    <dbReference type="OrthoDB" id="2021186at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029523">
        <property type="entry name" value="INO80B/Ies2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006880">
        <property type="entry name" value="INO80B_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561:SF12">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04795">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01406">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit B-like conserved region" evidence="2">
        <location>
            <begin position="295"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU42574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="397" mass="43701" checksum="9873E78C501D75B9" modified="2009-10-13" version="1">MSSRPRRSAATRANEVISVHARMADSPERNERSERSMSSRRSGRASGVSVSRDAPSPGGDRHLSLTVKMPSNKLRQATRGGRGFEGGEIVSGKRNRGAKKSYVVDSSPDEDEEEEEEAEIEVEEEDDDDMEEDAEGEDDMDVDAEGEDAEGDIDMDLAPPPPTITVSKPSRSKPAPRGSALKVVQDDDDDDDLSDPADSDAGDETMGFGDETMADEDAEGEEIEVAGQEGDEEEEEEEEADSDDEGSQDESPDLTKMTKRQRARFEDEPQQYMKLSDGLTIWAEVQAKKVFTAEELSMRRQEMARRRRNLSEKRNEEVKMETINKLLKKQAPKVSRKAAGNGDGGDDSQKPNPAFVRWVSNKSGVRVAVTEEMLESPAGTIFGPASKPVSRKLVEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZQ4</accession>
    <name>C7YZQ4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_95788</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048552.1">
        <property type="nucleotide sequence ID" value="XM_003048506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZQ4"/>
    <dbReference type="GeneID" id="9667629"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95788"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95788"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_27_2_1"/>
    <dbReference type="InParanoid" id="C7YZQ4"/>
    <dbReference type="OMA" id="YSSFYME"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF11">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="30"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="496"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="496"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="514"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU42839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="526" mass="58303" checksum="BED2836F19427315" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z012</accession>
    <name>C7Z012_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_47843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048601.1">
        <property type="nucleotide sequence ID" value="XM_003048555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z012"/>
    <dbReference type="STRING" id="660122.C7Z012"/>
    <dbReference type="GeneID" id="9667498"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_47843"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_47843"/>
    <dbReference type="eggNOG" id="ENOG502S3EN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070658_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z012"/>
    <dbReference type="OMA" id="CPMNIEA"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016034">
        <property type="term" value="F:maleylacetoacetate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03194">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03043">
        <property type="entry name" value="GST_N_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673:SF4">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU42888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="229" mass="26026" checksum="3D0BB7D3F9AEFF07" modified="2009-10-13" version="1">MTYTLFIGNKRYSSWSMRPWVLLKVLDIPFEEKLHLFKPGPRQPHFIAFSPTGKVPCLQDEDTSILVWDSLAICEYIAEKYPAAWPADAAARAFARSAAAEMHSGFNAIRDECSMNVGLRIELGTPSEALQRDISRFNALFKEGTEKFGGPWLAGDQFTIVDAMYAPIASRCKTYGVELEGEAQEYVDRLFNHPVVQEWVQDGIYETEREPDHEDDCVRGRKILQDLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z056</accession>
    <name>C7Z056_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_47292</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048439.1">
        <property type="nucleotide sequence ID" value="XM_003048393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z056"/>
    <dbReference type="STRING" id="660122.C7Z056"/>
    <dbReference type="GeneID" id="9667516"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_47292"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_47292"/>
    <dbReference type="eggNOG" id="ENOG502R94Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009030_0_1_1"/>
    <dbReference type="InParanoid" id="C7Z056"/>
    <dbReference type="OMA" id="WRILHIP"/>
    <dbReference type="OrthoDB" id="5089701at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF25">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU42726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="733" mass="81914" checksum="15AC02AC18F9843E" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z098</accession>
    <name>C7Z098_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxypeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_47349</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048464.1">
        <property type="nucleotide sequence ID" value="XM_003048418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z098"/>
    <dbReference type="MEROPS" id="S10.016"/>
    <dbReference type="GeneID" id="9667541"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_47349"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_47349"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008523_10_3_1"/>
    <dbReference type="InParanoid" id="C7Z098"/>
    <dbReference type="OMA" id="AAQYICQ"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF131">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988406" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="517"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="520"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU42751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="60419" checksum="E82273BBDD0448AD" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0C3</accession>
    <name>C7Z0C3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Arabinogalactan endo-beta-1,4-galactanase</fullName>
            <ecNumber evidence="3 7">3.2.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_40212</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>The enzyme specifically hydrolyzes (1-&gt;4)-beta-D-galactosidic linkages in type I arabinogalactans.</text>
            <dbReference type="EC" id="3.2.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 53 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.89" evidence="3 7"/>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048067.1">
        <property type="nucleotide sequence ID" value="XM_003048021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0C3"/>
    <dbReference type="STRING" id="660122.C7Z0C3"/>
    <dbReference type="GeneID" id="9671873"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_40212"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_40212"/>
    <dbReference type="eggNOG" id="ENOG502QU6R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011259_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z0C3"/>
    <dbReference type="OMA" id="KYIHDEW"/>
    <dbReference type="OrthoDB" id="110914at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031218">
        <property type="term" value="F:arabinogalactan endo-1,4-beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000077">
        <property type="entry name" value="Arabinogalactan endo-beta-1,4-galactanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011683">
        <property type="entry name" value="Glyco_hydro_53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34983">
        <property type="entry name" value="ARABINOGALACTAN ENDO-BETA-1,4-GALACTANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34983:SF1">
        <property type="entry name" value="ARABINOGALACTAN ENDO-BETA-1,4-GALACTANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07745">
        <property type="entry name" value="Glyco_hydro_53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005125810" description="Arabinogalactan endo-beta-1,4-galactanase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00068680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU42354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="349" mass="38261" checksum="085D613A2DEF104F" modified="2009-10-13" version="1">MVALRFLAFISYCSLALSALTYRGVDWSSLLLEEAKGIKYTNGGSSQSLEKILVANGVNSVRQRVWVNPSNGDYNLDYNLKLAKRAKAAGLSVYLTLHFSDTWADPANQKIPSGWPTGIDDLAWRLYNYTLQVSNAFQSAGVQPSIISIGNEITAGLLFPTGSTKSFYNIGRLLNSASFGIKDSSLNPKPKIMIHLDKGWDWGTQEYFYTNVFNAGGLKTSDIDMMGVSYYPFYGAGATFSALETSLKNLASKWGKEIVVSELNWPTSCPSPAQAFPSDMRNIPFSAAGQTQFIEKVASIVSKVNRGRGLYYWEPAWMNNQALGSSCNSNTLFSWPGAALSSLSVFKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0R2</accession>
    <name>C7Z0R2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_39825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048141.1">
        <property type="nucleotide sequence ID" value="XM_003048095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0R2"/>
    <dbReference type="GeneID" id="9671943"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_39825"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_39825"/>
    <dbReference type="eggNOG" id="ENOG502S4MS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094640_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z0R2"/>
    <dbReference type="OMA" id="MWRSARN"/>
    <dbReference type="OrthoDB" id="9975758at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU42428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="153" mass="17585" checksum="45C56D89268D78B8" modified="2009-10-13" version="1">MWRDARNVRITYKLLPGTADGRPRLDDLVEYEPTSKDGLRKTVEGIDTQATSTGWDWRGKGWLLFVSSHWEILGWGEATTADGVKEKWAVTWFAPTVFTKEGLDIYCDRKEGLSEETYAAIREALKGLEAKKVVEMVEKHMQPVEIRLPWLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z139</accession>
    <name>C7Z139_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_80104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048215.1">
        <property type="nucleotide sequence ID" value="XM_003048169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z139"/>
    <dbReference type="GeneID" id="9671996"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_80104"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_80104"/>
    <dbReference type="HOGENOM" id="CLU_1205064_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z139"/>
    <dbReference type="OrthoDB" id="5061645at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="230" mass="26012" checksum="A9CB96566447C5CA" modified="2009-10-13" version="1">MDTESAEHLFEGMDTDENQPDEDEDEAEGYDPDEDERFLSHIYGPPPADLIPDTPRPSRAEHIPIPRENLNFGIDENAPAFSSIAFLVIMLEPEAPGGKCQWTFAMRNHTTDMWHSQVLYVSPGPEPELSVDVHYHNPTELPNYVETITFKERRIPHRTAARIIDACMAVKIPNCAHRECPSADYVIDVVEELERLGAIDLFDMYELLTQTAKYGINPLDSDEEEAEGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1S8</accession>
    <name>C7Z1S8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_50957</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU41876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047589.1">
        <property type="nucleotide sequence ID" value="XM_003047543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1S8"/>
    <dbReference type="STRING" id="660122.C7Z1S8"/>
    <dbReference type="GeneID" id="9671552"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_50957"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_50957"/>
    <dbReference type="eggNOG" id="KOG3867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_9_2_1"/>
    <dbReference type="InParanoid" id="C7Z1S8"/>
    <dbReference type="OMA" id="ATDEIWR"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004423">
        <property type="term" value="F:iduronate-2-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16150">
        <property type="entry name" value="sulfatase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45953">
        <property type="entry name" value="IDURONATE 2-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45953:SF1">
        <property type="entry name" value="IDURONATE 2-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="4">
        <location>
            <begin position="25"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU41876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="520" mass="59196" checksum="1AF552B3ECA97190" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z224</accession>
    <name>C7Z224_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_85999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU42100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047813.1">
        <property type="nucleotide sequence ID" value="XM_003047767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z224"/>
    <dbReference type="GeneID" id="9671774"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85999"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85999"/>
    <dbReference type="HOGENOM" id="CLU_1825792_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z224"/>
    <dbReference type="OrthoDB" id="5354164at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU42100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="141" mass="15627" checksum="AD55E63D235507E6" modified="2009-10-13" version="1">MAVIHEVLLFPSSISITTTEPAEACFNRLFSCHVLFVVESMTLLAVDCLKNRTTKPSFFSNYFNQSNDQEADEIGQDLDPNMLKEVTAFSVGDSIYSLSILSSDTRTKPQTVFYDNISDTKGTSIVRTFGNMGKHGISILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z230</accession>
    <name>C7Z230_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fido domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_86005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU42103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047816.1">
        <property type="nucleotide sequence ID" value="XM_003047770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z230"/>
    <dbReference type="STRING" id="660122.C7Z230"/>
    <dbReference type="GeneID" id="9671777"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86005"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86005"/>
    <dbReference type="eggNOG" id="ENOG502S5GA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115697_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z230"/>
    <dbReference type="OMA" id="DIPMAHD"/>
    <dbReference type="OrthoDB" id="3049701at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1870">
        <property type="entry name" value="Fic/DOC protein, Fido domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006440">
        <property type="entry name" value="Doc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053737">
        <property type="entry name" value="Type_II_TA_Toxin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01550">
        <property type="entry name" value="DOC_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39426">
        <property type="entry name" value="HOMOLOGY TO DEATH-ON-CURING PROTEIN OF PHAGE P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39426:SF1">
        <property type="entry name" value="HOMOLOGY TO DEATH-ON-CURING PROTEIN OF PHAGE P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="Fic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="1">
        <location>
            <begin position="39"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="171" mass="19317" checksum="24BFB2D2BCB9202C" modified="2009-10-13" version="1">MNAFSRSMHEFQLLSSISTYSLEHSPLRIMSSAAPCRFLTVAQVKRLHMRHIAKASPTQPAMLESAVNSPVNHEHYGQKDLFVLAGVLAEKIALDHSYQDGNKRTALYAADMFLKMNGHQLQKRTNGESEAEFNEELSDAHVLVATRRWTPEDLGNYYRSIAEALVKNQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z238</accession>
    <name>C7Z238_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_86013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU42106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047819.1">
        <property type="nucleotide sequence ID" value="XM_003047773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z238"/>
    <dbReference type="GeneID" id="9671782"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86013"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86013"/>
    <dbReference type="HOGENOM" id="CLU_1008626_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z238"/>
    <dbReference type="OrthoDB" id="5104597at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="276" mass="31093" checksum="9AEB33DCB325F99E" modified="2009-10-13" version="1">MSNINQLNMPNMDNLNSEERRIFAQMRTRAQRDAGRTSTPEVNDVEMSTPTSPPHQMFGQSPHEHLQAQLGLADRVASRFSKPSQDTLPGELYLIQGRLGSSVLRPRQRMGVFKLSLEYLALGIVASYQLTPRTTSTELATTTTDLATAASDENDDDTNTRLEEIERKHRKVLKEYDEKIKEIGEQISVCDQEFSRIEADNDNVNNIMLRHERHVNEQIARQNNRITTLAELARLDGIEARLAQLDGIEASLARLDERVTAIVAHLNTVAMGKMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z241</accession>
    <name>C7Z241_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bacteriophage T5 Orf172 DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_64257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU42107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047820.1">
        <property type="nucleotide sequence ID" value="XM_003047774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z241"/>
    <dbReference type="STRING" id="660122.C7Z241"/>
    <dbReference type="GeneID" id="9671784"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_64257"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_64257"/>
    <dbReference type="eggNOG" id="ENOG502QWMU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024511_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z241"/>
    <dbReference type="OMA" id="AAAYFCW"/>
    <dbReference type="OrthoDB" id="2417614at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053006">
        <property type="entry name" value="Meiosis_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018306">
        <property type="entry name" value="Phage_T5_Orf172_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094:SF2">
        <property type="entry name" value="BACTERIOPHAGE T5 ORF172 DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 113 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10544">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00974">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacteriophage T5 Orf172 DNA-binding" evidence="2">
        <location>
            <begin position="281"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU42107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="399" mass="44215" checksum="7D5E0ABE5FE71B74" modified="2009-10-13" version="1">MPFVANTPESLLSRSDSKNPSSTCRGITSNGRPCRRPVPAKPATSRPSTPDPRDESLYCWQHREQATMSAHSSPGPRATATPILEGRTSLDTLADRLGLIELQDKKKRRQRTDGGGRKTSTPKPKPKQTLSCCFCFSIPLEEVPETRPARPQPRPVQRSSIPVPPKRNSKQHLSASQDTSPGKSSRRTCKSTGSQIKDFIPDSLDTSTVSALLTELARPFVDSEEPGFIYMFWLTPTSDSTSAPVDAARSLLAPPSPSRPSRSRRPSDVVSSFAATDPSTARSTMLLKIGRASNVQRRLNQWQRQCGHEVEMLRYYPYIPGSQESSGVVPHMTTHVHRVERLVHIELAGMGLKANGGKCEACGREHREWFEVEATREGIRAVDGVIRRWIEWDETNPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z2A9</accession>
    <name>C7Z2A9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_72599</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU42141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047854.1">
        <property type="nucleotide sequence ID" value="XM_003047808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z2A9"/>
    <dbReference type="GeneID" id="9671818"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_72599"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_72599"/>
    <dbReference type="eggNOG" id="ENOG502QXCY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_361716_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z2A9"/>
    <dbReference type="OMA" id="TCIGWPA"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03024">
        <property type="entry name" value="DsbA_FrnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887:SF41">
        <property type="entry name" value="THIOREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988875" description="AB hydrolase-1 domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="96"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="4">
        <location>
            <begin position="420"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="3">
        <location>
            <begin position="556"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU42141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="773" mass="84797" checksum="5BB46CF9535CC560" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z2D2</accession>
    <name>C7Z2D2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_50893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU41983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047696.1">
        <property type="nucleotide sequence ID" value="XM_003047650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z2D2"/>
    <dbReference type="GeneID" id="9671481"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_50893"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_50893"/>
    <dbReference type="eggNOG" id="ENOG502R71Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023620_5_0_1"/>
    <dbReference type="InParanoid" id="C7Z2D2"/>
    <dbReference type="OMA" id="IPGPRCL"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01299">
        <property type="entry name" value="Met_dep_hydrolase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057744">
        <property type="entry name" value="OTAase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="117"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU41983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="502" mass="55825" checksum="38518CBA356F73EA" modified="2009-10-13" version="1">MTKDDITKASWPQGAHDSWGKEPIHSQKVPRNVEFINNLKLDKKLQPKDYHIDGTHQRSKILFINVKILDSTGREPYSGDVLIEAGEKIAAVGQIPNKAEIERDPLVRVFEGRGRTLMSGLGDGHTHFTWNGGDLNRLGELDIEEHVLLTIKSAQCFLDSGYTMCFGAAAAKDRLDVVVRDAINAGDIPGPRYLANAREIAKPEGELVAGITRFADGPQEMRDAIKYNIETIGVDNVKLSISGEEITEIRSAQDCYFSDEEIIACVDEAHKRGKRVCAHARARDSVKMCVKHGVDVIYHGSYVDDEVGMDMLEQDKHKNIVVPAINWLYATTYEADAFGYTYEAAEKAGYKRELDIAVAGLREMHRRGIVVLPGGDYGFAWTPHGTYARDLEHFVKMLGFTPHESIIAATAGVAALMMRGHELGRIQPGYFADCILVDGDPLEDISILQDHDKLNIIIMNGRVHKAGRKEYIRDTSGSLSSGIPRHLAEEFPEKRPAMQKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z2U1</accession>
    <name>C7Z2U1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alginate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_97801</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047432.1">
        <property type="nucleotide sequence ID" value="XM_003047386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z2U1"/>
    <dbReference type="GeneID" id="9676094"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_97801"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_97801"/>
    <dbReference type="eggNOG" id="ENOG502QVUY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038125_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z2U1"/>
    <dbReference type="OMA" id="GHAMLDF"/>
    <dbReference type="OrthoDB" id="5302720at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008397">
        <property type="entry name" value="Alginate_lyase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05426">
        <property type="entry name" value="Alginate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988885" description="Alginate lyase domain-containing protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Alginate lyase" evidence="4">
        <location>
            <begin position="53"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU41719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="389" mass="42935" checksum="B116B6AC13B7B8D9" modified="2009-10-13" version="1">MKISLLTAVGIVTSAATFVHPGLLHSEADFSRIKKFVDSGKAPWSVGWEKLVARANPDYQPRPQEILVRGSTPELPENYVLLYRDLASAYALAIRWKITQDTDFAEAAVCIVDAWAASLTDIWGNSDKFLAAGIYGYQFANVVEILRTYPSWKGLEAATEMLLRVFYPMNRRFLIEHNDAHIENYWANWDQCNIASMMSIGVLADNHTIWDEAVEYFKHGAGNGAIEKAIWAIHTEEGTGKKLGQNQEAGRDQGHATLDFALLGVIAQQAHNQGEDLFGYLENRILAGMEYMSKYNVGEDVPFTTYVNAVHGTQTGISSAGRGTIRPMAELFVAHYGSLKGRDVKWTKAYRDLVIEKSGGAEGGGGDYGTTSGGYDQLGFGTLLYRLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z427</accession>
    <name>C7Z427_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_83456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046958.1">
        <property type="nucleotide sequence ID" value="XM_003046912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z427"/>
    <dbReference type="STRING" id="660122.C7Z427"/>
    <dbReference type="GeneID" id="9675294"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83456"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83456"/>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049471_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z427"/>
    <dbReference type="OMA" id="IAYIMVM"/>
    <dbReference type="OrthoDB" id="10252009at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140096">
        <property type="term" value="F:catalytic activity, acting on a protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990444">
        <property type="term" value="F:F-box domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062026">
        <property type="term" value="P:negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070372">
        <property type="term" value="P:regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052449">
        <property type="entry name" value="STYX-Interacting_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588">
        <property type="entry name" value="SERINE/THREONINE/TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588:SF1">
        <property type="entry name" value="SERINE_THREONINE_TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="77"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU41245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="303" mass="33557" checksum="C78023A77AE5B036" modified="2009-10-13" version="1">MAVPSAPYTFRPPSPPFIHIPPTAHGSGGDSIPGLLPSYENVDPQQLTPRDVAIITQNVTHAPTDRASDWSYEQRREAQPLLNFLYLGPNSAARDGEFLRSEGITMVLVARDARMAGMKLMSIEKVAQTLGIVVHYVDMDGYDNMISSFSNTIRAVNDHLLTIYHSQAQGRSKDGSLVVETATFRRGKVLVACETGNDRSAAMAAAYIMALFGKDMITTIQFISVQRFCCCFDEDVKRKLQSWEDILRARSQVASQAKIAGQHGKRHIDEVMETQGNSDQGDSVALDHDRFQGRDAFVPFMDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4W9</accession>
    <name>C7Z4W9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH-ubiquinone oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_66641</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the complex I NDUFA8 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046710.1">
        <property type="nucleotide sequence ID" value="XM_003046664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4W9"/>
    <dbReference type="SMR" id="C7Z4W9"/>
    <dbReference type="STRING" id="660122.C7Z4W9"/>
    <dbReference type="GeneID" id="9678515"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_66641"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_66641"/>
    <dbReference type="eggNOG" id="KOG3458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081931_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z4W9"/>
    <dbReference type="OMA" id="FRTHWQC"/>
    <dbReference type="OrthoDB" id="276296at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016680">
        <property type="entry name" value="NDUFA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017016">
        <property type="entry name" value="NDUA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CHCH" evidence="10">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU40997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="173" mass="19759" checksum="37D1089F0734DDEF" modified="2009-10-13" version="1">MSTRRPQFNQQVLIDTTPLPDDIPAVKEVGASSAPLLSASFFIGARCRDYNDDYMQCKNENPGRGELECLKEGRRVTRCASSVIQDINTHCLAEFRKHWECLDDRNHQLWQCRPAEWKLNKCVFDNLKLEKKVPDQPTNVTPVHLRPKQIFADVRIGPGDGKPFIPGQEEAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z541</accession>
    <name>C7Z541_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_34067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU41034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046747.1">
        <property type="nucleotide sequence ID" value="XM_003046701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z541"/>
    <dbReference type="GeneID" id="9678274"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_34067"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_34067"/>
    <dbReference type="eggNOG" id="ENOG502SPB5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_457112_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z541"/>
    <dbReference type="OMA" id="LRMGETH"/>
    <dbReference type="OrthoDB" id="5134073at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU41034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="556" mass="61282" checksum="7EB739790F3A53CA" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z5J7</accession>
    <name>C7Z5J7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_91373</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU41114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046827.1">
        <property type="nucleotide sequence ID" value="XM_003046781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z5J7"/>
    <dbReference type="FunCoup" id="C7Z5J7">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="GeneID" id="9678350"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_91373"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_91373"/>
    <dbReference type="eggNOG" id="KOG1418">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013394_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z5J7"/>
    <dbReference type="OMA" id="SFEEWAW"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000170">
        <property type="entry name" value="Outward-rectifier potassium channel TOK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000182">
        <property type="entry name" value="Outward-rectifier potassium channel TOK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF342">
        <property type="entry name" value="OUTWARD-RECTIFIER POTASSIUM CHANNEL TOK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="212"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="373"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="488"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="622"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="519"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="551"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="628"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="661"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU41114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="723" mass="82365" checksum="59601E8775AFB092" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z5W9</accession>
    <name>C7Z5W9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_57800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045740.1">
        <property type="nucleotide sequence ID" value="XM_003045694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z5W9"/>
    <dbReference type="GeneID" id="9678147"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_57800"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_57800"/>
    <dbReference type="eggNOG" id="KOG3010">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049344_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z5W9"/>
    <dbReference type="OMA" id="SETMFFE"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF10">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="47"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU40027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="306" mass="34068" checksum="8FA2124AF15BE112" modified="2009-10-13" version="1">MSEKTFRAYSQEQGKTYAQLRLDYNESLYQAILDFQKAGSGQFDTIIDIGCGPGTAVRKLAPNFKNAFGLDPSEGMISTARSLSTSDERIRFEVSSAETLGSELETPIPEESVDVITAATCAHWFDMPSFWERAAKVLKPGGTVAFWTGGDLRVDKTMAEHVALQAVVDELDEQLKDYFEPGNLLTRDLYRRIPLPWTCPTPVPEFDESSFKRLEWNTGPVSPSDCFFVKKQPLPPAVIELMLGTASPVTRWREAHPEAVGTEQDVLRVMRRKLEKILHDSGVEEGAELVHGDMEGALLLVRKKAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-11-30" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z622</accession>
    <name>3DHQ2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Catabolic 3-dehydroquinase 2</fullName>
            <shortName evidence="1">cDHQase 2</shortName>
            <ecNumber evidence="1">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">3-dehydroquinate dehydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">qutE2</name>
        <name type="ORF">NECHADRAFT_57823</name>
    </gene>
    <organism>
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Is involved in the catabolism of quinate. Allows the utilization of quinate as carbon source via the beta-ketoadipate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Aromatic compound metabolism; 3,4-dihydroxybenzoate biosynthesis; 3,4-dihydroxybenzoate from 3-dehydroquinate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homododecamer. Adopts a ring-like structure, composed of an arrangement of two hexameric rings stacked on top of one another.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-II 3-dehydroquinase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="1"/>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045762.1">
        <property type="nucleotide sequence ID" value="XM_003045716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z622"/>
    <dbReference type="SMR" id="C7Z622"/>
    <dbReference type="STRING" id="660122.C7Z622"/>
    <dbReference type="EnsemblFungi" id="NechaT57823">
        <property type="protein sequence ID" value="NechaP57823"/>
        <property type="gene ID" value="NechaG57823"/>
    </dbReference>
    <dbReference type="GeneID" id="9678443"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_57823"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_57823"/>
    <dbReference type="eggNOG" id="ENOG502S1A9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090968_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z622"/>
    <dbReference type="OMA" id="AYTHYSY"/>
    <dbReference type="OrthoDB" id="8191625at2759"/>
    <dbReference type="UniPathway" id="UPA00088">
        <property type="reaction ID" value="UER00178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046279">
        <property type="term" value="P:3,4-dihydroxybenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019631">
        <property type="term" value="P:quinate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00466">
        <property type="entry name" value="DHQase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9100">
        <property type="entry name" value="Dehydroquinase, class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00169">
        <property type="entry name" value="AroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001874">
        <property type="entry name" value="DHquinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018509">
        <property type="entry name" value="DHquinase_II_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036441">
        <property type="entry name" value="DHquinase_II_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01088">
        <property type="entry name" value="aroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003804">
        <property type="entry name" value="PRK05395.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003805">
        <property type="entry name" value="PRK05395.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003806">
        <property type="entry name" value="PRK05395.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003807">
        <property type="entry name" value="PRK05395.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272">
        <property type="entry name" value="CATABOLIC 3-DEHYDROQUINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272:SF3">
        <property type="entry name" value="CATABOLIC 3-DEHYDROQUINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01220">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001399">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52304">
        <property type="entry name" value="Type II 3-dehydroquinate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01029">
        <property type="entry name" value="DEHYDROQUINASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0672">Quinate metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000402368" description="Catabolic 3-dehydroquinase 2">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="102"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03136"/>
        </source>
    </evidence>
    <sequence length="153" mass="16662" checksum="00FC9BF41EEA7CD8" modified="2009-10-13" version="1">MSRRLLLINGPNLNLLGTREPHIYGSTTLQDVETQAKTQAKELSASIDTFQANSEGAIVDRIHAARGEIDAIIINAGAYTHTSVAIRDALTGVDIPFVEIHITNVHTREAFRHHSFLCDKAEAVICGLGVFGYTAAIEYAAKHIKLRGKASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z650</accession>
    <name>C7Z650_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Xylose isomerase-like TIM barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_32792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046350.1">
        <property type="nucleotide sequence ID" value="XM_003046304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z650"/>
    <dbReference type="STRING" id="660122.C7Z650"/>
    <dbReference type="GeneID" id="9668537"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_32792"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_32792"/>
    <dbReference type="eggNOG" id="ENOG502S1RE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035063_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z650"/>
    <dbReference type="OMA" id="HPFYNAE"/>
    <dbReference type="OrthoDB" id="5360893at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF21">
        <property type="entry name" value="XYLOSE ISOMERASE-LIKE TIM BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="1">
        <location>
            <begin position="26"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU40637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="351" mass="39480" checksum="09D7420A3F202E2E" modified="2009-10-13" version="1">MAHKPSICTMSLGRCFAGHSLPHKLDMAQKYGFQGIEVFYEDLVGFAKSYPGGGSPEDQIAAAGAIQQLCAARNLTIICLQPFMHFGGLINRGQHAKRIDELQFWFELVRALETDLILFPSSFLSEDEVTDDMDLIVADFIEAAELGLQQEPVVNFAYESLCWGTRTDTWESSWDLVQRVDRPNFGVCLDSYNILGRIYADPASPTGRTSDCEQATVDSIKRILSDIDITKVFLVQVADGERLSAPLDTSHPFYNPEQPARMSWSRNARLFYGEPQYGGYLPCKQLLRTVIQGLGFEGWLSFEVFNRRLAEPDAAVPEEMARRAAESWVKMKAELGLRTEDEMQPRLQAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6L5</accession>
    <name>C7Z6L5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-lactate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_33929</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046426.1">
        <property type="nucleotide sequence ID" value="XM_003046380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6L5"/>
    <dbReference type="STRING" id="660122.C7Z6L5"/>
    <dbReference type="GeneID" id="9668701"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_33929"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_33929"/>
    <dbReference type="eggNOG" id="KOG0068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_1_1"/>
    <dbReference type="InParanoid" id="C7Z6L5"/>
    <dbReference type="OMA" id="VIVTAHQ"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12183">
        <property type="entry name" value="LDH_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058205">
        <property type="entry name" value="D-LDH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43026">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE HOMOLOG 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43026:SF1">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE HOMOLOG 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="3"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="116"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU40713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="38439" checksum="1DB8022F06D8DDCD" modified="2009-10-13" version="1">MKVAVFSTKPYDKKYLSAVVACDKHASSGIELVFHEFALNEDTVSLVEGADAICVFVNDVVNDNVISALSEFGVKAILLRCAGFNNVDLDAAQRMRIMVANVPSYSPEAVAEFAVALIQTLNRKTHRAYNRVREGNFALDGLLGKTLCGKTVGIVGVGKIGLATARIMKGFGCTLLAYDPFPSPAFEEYGEYRDLEDLLPECDIVSLHCPLMDQTRHIINAESLALMKEGAMLVNTSRGGLIDTEAVIQSLKTNHIGGLALDVYEAEGELFYNDHSSHIIQDDMLMRLMTFPNVVVCGHQAFFTEEALTEIAECTINNLEDWITHKTSKNSLTKDLKMRRRDSLPVRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6R8</accession>
    <name>C7Z6R8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rho GDP-dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_57971</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rho GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045890.1">
        <property type="nucleotide sequence ID" value="XM_003045844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6R8"/>
    <dbReference type="FunCoup" id="C7Z6R8">
        <property type="interactions" value="455"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z6R8"/>
    <dbReference type="GeneID" id="9668091"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_57971"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_57971"/>
    <dbReference type="eggNOG" id="KOG3205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076228_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z6R8"/>
    <dbReference type="OMA" id="YKPTAAK"/>
    <dbReference type="OrthoDB" id="1683373at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005094">
        <property type="term" value="F:Rho GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.30:FF:000001">
        <property type="entry name" value="Rho GDP-dissociation inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.30">
        <property type="entry name" value="Coagulation Factor XIII, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000406">
        <property type="entry name" value="Rho_GDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024792">
        <property type="entry name" value="RhoGDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980:SF3">
        <property type="entry name" value="LD16419P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980">
        <property type="entry name" value="RHO GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02115">
        <property type="entry name" value="Rho_GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00492">
        <property type="entry name" value="RHOGDI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU40177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="198" mass="22290" checksum="9269BE65FE797228" modified="2009-10-13" version="1">MASHDDDTMPEETQGYKLSQPKQSLAEYQQMDAGDESLQRYKESLGLGGGTDISDPNDPRVCIILSLTMDSPGRDPVTIDLSTPGSENTLKDKPFTIKEGAKFTMSAKFKVQHEILSGLHYVQVVKRKGIRVSKDSEMIGSYAPNTDRQTTYEKRFQEEEAPSGMLARGHYNAVSSFVDDDKKKHLEFEWSFDIAKDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z703</accession>
    <name>C7Z703_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pentatricopeptide repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_58033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045932.1">
        <property type="nucleotide sequence ID" value="XM_003045886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z703"/>
    <dbReference type="STRING" id="660122.C7Z703"/>
    <dbReference type="GeneID" id="9668209"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_58033"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_58033"/>
    <dbReference type="eggNOG" id="ENOG502T09I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_323127_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z703"/>
    <dbReference type="OMA" id="FSWLQFC"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="855"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="865"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="892"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU40219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="946" mass="106679" checksum="3912A82A9CFCE3EF" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z767</accession>
    <name>C7Z767_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_90933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045962.1">
        <property type="nucleotide sequence ID" value="XM_003045916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z767"/>
    <dbReference type="STRING" id="660122.C7Z767"/>
    <dbReference type="GeneID" id="9668243"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90933"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90933"/>
    <dbReference type="eggNOG" id="ENOG502S0S8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009124_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z767"/>
    <dbReference type="OMA" id="TVQACVF"/>
    <dbReference type="OrthoDB" id="1749473at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="670"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="450"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="729"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="763"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU40249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="838" mass="92225" checksum="99C8E8AB78EB3B53" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z782</accession>
    <name>C7Z782_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_66336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046540.1">
        <property type="nucleotide sequence ID" value="XM_003046494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z782"/>
    <dbReference type="STRING" id="660122.C7Z782"/>
    <dbReference type="GeneID" id="9668250"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_66336"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_66336"/>
    <dbReference type="eggNOG" id="ENOG502S06P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071891_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z782"/>
    <dbReference type="OMA" id="IHRGVQM"/>
    <dbReference type="OrthoDB" id="5220781at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU40827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="329" mass="35944" checksum="D9E217F66D3DECA9" modified="2009-10-13" version="1">MVSHIRSFAPAFEEVKVAQITESRISNVVAMLPVSLQSGPIRFLRRSISLHTLRPGVVVPAAQSKPRPLSEADAAALNAEPLETGILTQRDEPQYTEAEAARPHGMSRVLYSETKDDEQVVRAASGIHWKFARQGTNLVNISIDGGRPAVTEEDITFERKAFVDGVTYLLKALPQDLDDCELKRVQSALPQDVNPPNLNRGQLQTSSSRAGPSRKRSILHRGVQMTVVNLIFFLSFLMPYLLYLIRCAARLERKYKISEVVVGHGIDFVNSIGKQSASLTETIGQMNDGKVGQALLEAFVWTVDGVTQGISDGLGEGLSIVGSRSVQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7L0</accession>
    <name>C7Z7L0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="9">DOHH</shortName>
            <ecNumber evidence="9">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LIA1</name>
        <name evidence="11" type="ORF">NECHADRAFT_66463</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="9"/>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046606.1">
        <property type="nucleotide sequence ID" value="XM_003046560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7L0"/>
    <dbReference type="FunCoup" id="C7Z7L0">
        <property type="interactions" value="900"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z7L0"/>
    <dbReference type="GeneID" id="9669016"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_66463"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_66463"/>
    <dbReference type="eggNOG" id="KOG0567">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053974_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z7L0"/>
    <dbReference type="OMA" id="LQEPCSI"/>
    <dbReference type="OrthoDB" id="421002at2759"/>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03101">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027517">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU40893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="324" mass="35474" checksum="69D5B20E595787EB" modified="2009-10-13" version="1">METVLKLRESLCSEDTPLPIRFRALFSLKHVAVTQINPEDVKVAAIEAIAAGFTSPSALLKHELAYCLGQTCNTAAVKPLREVLADLKEDPMCRHEAAEALGALGWADNLDILREYRDRKGEDISIVETCEIAIERVEWENSEERQKEKLRPSAFSSIDPAPPMPETDKKAEVAELGRKLMDTKAPLFIRYRAMFALRDLASPPDLPTAVPAVLELAKGFADSSALFRHEIAFVFGQLSHPASIPSLTAALSDVNEASMVRHEAAEALGSLGDEEGVEDTLRRFLHDKEKVVRESVIVALDIADYEKGGETEYALIPEVGGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7X9</accession>
    <name>C7Z7X9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_79595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045482.1">
        <property type="nucleotide sequence ID" value="XM_003045436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7X9"/>
    <dbReference type="GeneID" id="9672517"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79595"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79595"/>
    <dbReference type="HOGENOM" id="CLU_719782_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z7X9"/>
    <dbReference type="OrthoDB" id="10413570at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU39769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="43833" checksum="5B35F51E30BCBC5C" modified="2009-10-13" version="1">MSSLPDHVWYLILCLFEVDIPVERWQSCEPARPHRANLRQATGAISMYNWNLVPRPLQTYLDLVYGRWLMDLLKEARTLLDLPPAVGGRLDAALNPMPSSMGLDTLILALTPRVRLVDVTVPSTVPNNGSSPLPWILGGQEDEPVRHGLSRCCLPLLTEVRLTRDRYRPENFDLVELEPLLLHPTLKILRVCKFECRARHVSELKWPDRVSKLETLELRECFLDSTGMRSILARCSNIRRLAIHLGGEPSQLELWQDHLISRRSRQPTEYRILETLDLTLFSQMLRELAKDLIELGLNTARYRDTNEIPGEIEFLHELGSLRCLKLTPRDLGNPVSLSGKLPPSLESLVLYYHALPGYDRQPTEDLAKVIAADGHPNLRVASWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7Z2</accession>
    <name>C7Z7Z2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_79608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045622.1">
        <property type="nucleotide sequence ID" value="XM_003045576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7Z2"/>
    <dbReference type="STRING" id="660122.C7Z7Z2"/>
    <dbReference type="GeneID" id="9672391"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79608"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79608"/>
    <dbReference type="eggNOG" id="ENOG502SNDZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015092_4_2_1"/>
    <dbReference type="InParanoid" id="C7Z7Z2"/>
    <dbReference type="OMA" id="GMCSKCE"/>
    <dbReference type="OrthoDB" id="5376804at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="631"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU39909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="714" mass="78426" checksum="556642B51E890842" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8D8</accession>
    <name>C7Z8D8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14 17">Homoserine dehydrogenase</fullName>
            <shortName evidence="14">HDH</shortName>
            <ecNumber evidence="5 14 17">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">NECHADRAFT_93154</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of L-aspartate-beta-semialdehyde (L-Asa) to L-homoserine (L-Hse), the third step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine; production of homoserine leads to a branch-point in the pathway as it can either be O-phosphorylated for processing to threonine, or O-acylated for processing to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-homoserine + NADP(+) = L-aspartate 4-semialdehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:15763"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:25213"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 17">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14 18">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="5 14 17"/>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045692.1">
        <property type="nucleotide sequence ID" value="XM_003045646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8D8"/>
    <dbReference type="FunCoup" id="C7Z8D8">
        <property type="interactions" value="378"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z8D8"/>
    <dbReference type="GeneID" id="9672467"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_93154"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_93154"/>
    <dbReference type="eggNOG" id="KOG0455">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009116_0_1_1"/>
    <dbReference type="InParanoid" id="C7Z8D8"/>
    <dbReference type="OMA" id="NICTAKS"/>
    <dbReference type="OrthoDB" id="67851at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000006">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011147">
        <property type="entry name" value="Bifunc_Aspkin/hSer_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022697">
        <property type="entry name" value="HDH_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070:SF5">
        <property type="entry name" value="HOMOSERINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036497">
        <property type="entry name" value="HDH_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 14 17" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="9 14 16" id="KW-0521">NADP</keyword>
    <keyword evidence="10 14 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14 17" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Aspartate/homoserine dehydrogenase NAD-binding" evidence="20">
        <location>
            <begin position="14"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Homoserine dehydrogenase catalytic" evidence="19">
        <location>
            <begin position="156"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>L-homoserine</name>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR036497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF03447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EEU39979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="366" mass="39316" checksum="045D88B54146A4E7" modified="2009-10-13" version="1">MTRSIPEVSIAVIGAGGVGSVFLQQLAWVAKNKTSHSLRLVYVAIIDKALYHADYASIDIVSAVPTLEEKGGPLPTISQTIEYLTGAPGKVIVVDNTSSQAVAEAYPSFLSRGFCVVTPNKKAFSGSWKLWEDIFAAEGTAGSMVYHECSVGAALPIISTLKELIATGDEITRIEGVFSGTMSYLFNNFAPTQGTGGKWSDEVKRAKQLGYTEPDPRDDLNGLDVARKITILARLAGLPIEFVTAFPVQSLIPKELESVKSGDEFLQRLPEFDTHMNEHKEAAKKADKVVRFIGSVDVVTKQLKVGLEAFDKSHPIASLKGSDNIISFYTRRYGDLPLIVQGAGAGGPVTAMGVLGDLLKVLTRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8L5</accession>
    <name>C7Z8L5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="6">2.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_70106</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + acetyl-CoA = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:17017"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="2.3.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="6">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.12" evidence="6"/>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU38977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044690.1">
        <property type="nucleotide sequence ID" value="XM_003044644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8L5"/>
    <dbReference type="FunCoup" id="C7Z8L5">
        <property type="interactions" value="1116"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z8L5"/>
    <dbReference type="GeneID" id="9673525"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_70106"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_70106"/>
    <dbReference type="eggNOG" id="KOG0557">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_10_2_1"/>
    <dbReference type="InParanoid" id="C7Z8L5"/>
    <dbReference type="OMA" id="TMEFESF"/>
    <dbReference type="OrthoDB" id="537444at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000003">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006257">
        <property type="entry name" value="LAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01349">
        <property type="entry name" value="PDHac_trf_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF90">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 6" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="36"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="9">
        <location>
            <begin position="178"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="130"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU38977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="458" mass="48912" checksum="D50941CF987B1E6C" modified="2009-10-13" version="1">MLSVALRRRLLAPTHNALRTGFAAHVVRHYASFPEHQVVKMPALSPTMQHGNIGSWQKKPGDSIAPGDVLVEIETDKAQMDFEFQEEGVIAKILKESGEKDVPVGSPIAVLVEEGTDISAFEKFSIEDAGGAAAPAAPKEEKTESKSEPSSTPASTPEPEQYTSSEGRLQTALDREPNMSAAAKRLARENGISIDSLKGTGQGGKITEEDVKKALSSPVAAAPGATFEDTPISSMRKTIANRLVESTQTNPHFYVTSSVSVSKLLKLRQALNSSADGKYKLSVNDFLIKAMAIASRKVPQVNSSWREGNIRQFNSVDVSVAVSTPTGLITPIVTGVEGRGLEAISSKVKELAKKARDGKLKPEEYQGGTISISNMGMNPAVDHFTAVINPPQAAILAVGTTRKVAVPAQNEDGSAGVEFDDQISLTASFDHKVVDGAIGAEWLRELKKVLENPLELLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAD2</accession>
    <name>C7ZAD2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_82058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045369.1">
        <property type="nucleotide sequence ID" value="XM_003045323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAD2"/>
    <dbReference type="GeneID" id="9672150"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82058"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82058"/>
    <dbReference type="HOGENOM" id="CLU_1777971_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZAD2"/>
    <dbReference type="OrthoDB" id="5105131at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="146" mass="16830" checksum="2693DFD52A7BE2FA" modified="2009-10-13" version="1">MHMAFTLTQKRRARDKTTTRYNKPADAAENVWPRNTGSVAALIRRTLARTGIIGSLASRFVVPVKTKHQKRARKSVKRMQGFKKDLLRKVNYPTDAMDLERAIQKLCYTNTPVKQQSSRHPHAKLRLSRTPMLRPHIPDLPMHPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAK7</accession>
    <name>C7ZAK7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_43272</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045407.1">
        <property type="nucleotide sequence ID" value="XM_003045361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAK7"/>
    <dbReference type="GeneID" id="9672362"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_43272"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_43272"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_4_2_1"/>
    <dbReference type="InParanoid" id="C7ZAK7"/>
    <dbReference type="OMA" id="FQCTSYV"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="512"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU39694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="62649" checksum="4DEDF595C0C553F9" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZB03</accession>
    <name>C7ZB03_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_45735</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044418.1">
        <property type="nucleotide sequence ID" value="XM_003044372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZB03"/>
    <dbReference type="GeneID" id="9670735"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45735"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45735"/>
    <dbReference type="eggNOG" id="ENOG502S5AR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055491_3_6_1"/>
    <dbReference type="InParanoid" id="C7ZB03"/>
    <dbReference type="OMA" id="KYTEMHE"/>
    <dbReference type="OrthoDB" id="9985472at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF30">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03180)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU38705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="139" mass="15024" checksum="63EAA8EBB8EAE7E7" modified="2009-10-13" version="1">MASETTGSCLCGACAYSYAGEPAVKALCYCGPCRRVSGGTNTVNFVIPEEKFTVKKGQTKSYSAQHEYGMTLTIFFCPDCGSTLWKEATAEQFRGVKLIQGGSLDDAKKLNVTIDAEFYAPERASYLAPIENAAQSKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZB95</accession>
    <name>C7ZB95_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_83018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044370.1">
        <property type="nucleotide sequence ID" value="XM_003044324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZB95"/>
    <dbReference type="GeneID" id="9670792"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83018"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83018"/>
    <dbReference type="eggNOG" id="ENOG502SYH5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1434791_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZB95"/>
    <dbReference type="OMA" id="AANTWSC"/>
    <dbReference type="OrthoDB" id="5091578at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988683" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="20195" checksum="A3F049DC5BC0B179" modified="2009-10-13" version="1">MARIFFLLTAFAGMALAKNVSFTSGDATGCISLSHIQALGQTFDWLNANSTSDASLPAVPEHFINAPSECIPESLYDLYFEPIVEMAKKEDLLANLDSVLEFVGGEHSIHKRARNCPQIKDAALKKASSFSCNSAPHPSSCRSCANFSGINFVAACVACAAKANQESVFCCAAAATTFATYYSQVCLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBI9</accession>
    <name>C7ZBI9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_55184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <dbReference type="EMBL" id="GG698915">
        <property type="protein sequence ID" value="EEU38576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044289.1">
        <property type="nucleotide sequence ID" value="XM_003044243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBI9"/>
    <dbReference type="GeneID" id="9670665"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55184"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55184"/>
    <dbReference type="eggNOG" id="ENOG502T5YD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118202_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZBI9"/>
    <dbReference type="OMA" id="GHYESND"/>
    <dbReference type="OrthoDB" id="5235533at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16916" checksum="9FF521E3D3AA424F" modified="2009-10-13" version="1">MILPVCPRSLQKGEPIQTPWSTHVVVKEILVTTQVGNLTFYGVRAETQDSYPWDWLSTESLLWVFDDGTGPRMWQHPAQPVPYSFQEPENNLERIVGHYESRSGECYVAVKWKNCLSPTWELEENMGCLADALTCYFNNISDQSWAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCH5</accession>
    <name>C7ZCH5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_77054</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698918">
        <property type="protein sequence ID" value="EEU38369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044082.1">
        <property type="nucleotide sequence ID" value="XM_003044036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCH5"/>
    <dbReference type="STRING" id="660122.C7ZCH5"/>
    <dbReference type="GeneID" id="9670407"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77054"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77054"/>
    <dbReference type="eggNOG" id="ENOG502RH78">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021599_0_1_1"/>
    <dbReference type="InParanoid" id="C7ZCH5"/>
    <dbReference type="OMA" id="MCLMISE"/>
    <dbReference type="OrthoDB" id="4491390at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF9">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU38369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="497" mass="55733" checksum="DB1360A59A26ACDA" modified="2009-10-13" version="1">MKIRKITTCHTCRARKLACDGKRPSCSQCLFSSKKCAGYDHDLIFRPPVMSNSYPPKATKAKRQRRRVSVDSQKAQPVVTKQVTLPETEFPLTRSLSWPLLDIISLVVQNFSPVGQAPQFVPSQASIFSHRICGGWVEMLPELARGSKADLCLSPAIKTLAVSILARGSQGRAPMSDALAAHTTALESLNSGLDGWATSAPNIVAASIMCLFLSETQMIMPTSPTSAIVHAKGIEDLMKLQKPCFYASGISHHLFVGFRPVLTQVLQALFTRRKHFLSDPAWTSIPFEFYIPSPLQSLFTEVFPLAEILGRIDHLSDIPADQAVARAQKIVEELLEILQNLVRRDETVREETTARRWLPIFPVQEDLPIQFPDIIAGNFFTHLWAFQVICAYNIIKLTSKFPCLSTSTETKVLNDLLDVRMINQLALWTFRSIEFLLKEEFKLFGAASISLPLKTACEVLKAFGGNDPEMVFWFCRVSRFIKETGYYFLIQMLADDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDJ6</accession>
    <name>C7ZDJ6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_54743</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043666.1">
        <property type="nucleotide sequence ID" value="XM_003043620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZDJ6"/>
    <dbReference type="GeneID" id="9669867"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_54743"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_54743"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006937_8_1_1"/>
    <dbReference type="InParanoid" id="C7ZDJ6"/>
    <dbReference type="OMA" id="PFANFPP"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF5">
        <property type="entry name" value="DUAL-FUNCTIONAL MONOOXYGENASE_METHYLTRANSFERASE PSOF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU37953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="59855" checksum="F46E96E49446B81C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDT4</accession>
    <name>C7ZDT4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_102232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043520.1">
        <property type="nucleotide sequence ID" value="XM_003043474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZDT4"/>
    <dbReference type="GeneID" id="9669472"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102232"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102232"/>
    <dbReference type="eggNOG" id="ENOG502SZ3F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012355_0_1_1"/>
    <dbReference type="InParanoid" id="C7ZDT4"/>
    <dbReference type="OMA" id="YENDRYT"/>
    <dbReference type="OrthoDB" id="5273847at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056021">
        <property type="entry name" value="DUF7600"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24539">
        <property type="entry name" value="DUF7600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="224"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="712" mass="80259" checksum="E0A9068CD790D463" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDV2</accession>
    <name>C7ZDV2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycoside hydrolase family 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_123252</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043468.1">
        <property type="nucleotide sequence ID" value="XM_003043422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZDV2"/>
    <dbReference type="STRING" id="660122.C7ZDV2"/>
    <dbReference type="GeneID" id="9669610"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_123252"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_123252"/>
    <dbReference type="eggNOG" id="ENOG502SH4Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073364_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZDV2"/>
    <dbReference type="OMA" id="FEVMVWF"/>
    <dbReference type="OrthoDB" id="89349at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF9">
        <property type="entry name" value="XYLOGLUCAN-SPECIFIC ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU37755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="36767" checksum="D6D1EB5A1D5AEF05" modified="2009-10-13" version="1">MTIRFLVNFGLLALPIAITLGILFGLEKHREATGGPPLFKPQPDPTKPKTPNDNGITVGQYCQKSYGIHPETKGLEFTLNPNQWGVKDGGKGGMCLYVDIHNNKTYDTEFTAPNWASVWAYPIDDVKAPVHAFPNVMVEGDTFPVKLNTIEKIDIDFAWTYAPGNTSAKGSKYITKSDFDDLVDREVNANVAMDMFLDKDKEKSKVSEDASHEIMVWFAAIGAATQPIGFNGGTSPVATKTLHGVKFELYVGVNDETKQKVLTWYVKEPVEKFSGDLSPLINEILSMSDSDYPSPTDYLGYMAWGTEAYSSNNEYVTFNVTQLAIDVETTSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZE01</accession>
    <name>C7ZE01_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_54673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043649.1">
        <property type="nucleotide sequence ID" value="XM_003043603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZE01"/>
    <dbReference type="GeneID" id="9669750"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_54673"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_54673"/>
    <dbReference type="HOGENOM" id="CLU_002341_7_2_1"/>
    <dbReference type="InParanoid" id="C7ZE01"/>
    <dbReference type="OMA" id="NNREDIH"/>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="59"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU37936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="332" mass="38271" checksum="FC8043EAEBA82238" modified="2009-10-13" version="1" fragment="single">LREGVHVSSLDGGIQTQLGELLGLSGKTYDSVRKHRILRSLSFETMHRRIDQVHSAHAGTFDWILREGSFVDWLSHGRGVFHIAGKPGSGKSTLMRFLCYDPRTEERLEQWAAGSRVVRANYFFWRHGESDLQRNLEGLFRGLLHDSLSQCPDLIPDVLPELWEASKSSATPWLTDSSLKLQKDQIRDAFYKMINNRDLYCDHSFCFFIDGLDEYKETTREDYGDLVKLLFEWVDLAPQDVKLCVSSRELNIFETGRFNLDPKLKLRLHQLTKEDIETLVRDRLAELFPSTEEKEKSLDLSPLKRAVIERADGVFLWVALVLKSLREGWADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZE92</accession>
    <name>C7ZE92_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_87546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698921">
        <property type="protein sequence ID" value="EEU37621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043334.1">
        <property type="nucleotide sequence ID" value="XM_003043288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZE92"/>
    <dbReference type="GeneID" id="9669323"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87546"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87546"/>
    <dbReference type="eggNOG" id="ENOG502SUA7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102253_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZE92"/>
    <dbReference type="OMA" id="TAPTDCK"/>
    <dbReference type="OrthoDB" id="5356630at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002987042" description="Ubiquitin 3 binding protein But2 C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="19659" checksum="DB58E76FD8644727" modified="2009-10-13" version="1">MLFKTLVATVFAAASGLAAPLTARDDPFFAPSAIWQYNVRNGAISSATEGLVSKSTSNNGNDITTLLTFTYPSEAEGKQCQFAFYLDDGATLTGSKKLDLFTSNSPAPGPTSGWGPGNQRNIHLGRLSASLGSFATWDATYSTYLTEKTDCKASGTTEGFELVGVYDNDVVSWNPDVAGPRIIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEA0</accession>
    <name>C7ZEA0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_53446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698921">
        <property type="protein sequence ID" value="EEU37729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043442.1">
        <property type="nucleotide sequence ID" value="XM_003043396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEA0"/>
    <dbReference type="GeneID" id="9669327"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_53446"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_53446"/>
    <dbReference type="eggNOG" id="ENOG502S1P2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052213_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZEA0"/>
    <dbReference type="OMA" id="PLCVHWS"/>
    <dbReference type="OrthoDB" id="10005898at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="335" mass="37214" checksum="D9E7095FA29A6D2E" modified="2009-10-13" version="1">MTETRYNGLHSLSTSTQHLTPSSTEPPAPGETTSLATPQNAGIIESTPVPPEKKPVGFKAPVAIKKLDGFISHLNRLIHTRDGHDSVILFAAYVAQLAAAILETSGNANLQKWANKVLTLLPKALASRAPSLPLGSKLFSIFSAAPRLQLRLAERLRALVDMLDDWSVMSRLWGLLTMWMLAKEFITTPNTDDKEPRVRKVKTAISATQITSLIGFFILENISWLSRRKVLSWSDKSQPKLILWCVRSWGVYVFAELGRLLFERLRKKSGETGQEDAESRTQWNKQFVENLAWAPLTVHWTTPGGLLPESVAALLASYAQFISVQGLWKETAETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEB1</accession>
    <name>C7ZEB1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_53697</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698921">
        <property type="protein sequence ID" value="EEU37647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043360.1">
        <property type="nucleotide sequence ID" value="XM_003043314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEB1"/>
    <dbReference type="STRING" id="660122.C7ZEB1"/>
    <dbReference type="GeneID" id="9669170"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_53697"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_53697"/>
    <dbReference type="eggNOG" id="ENOG502QURZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010170_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZEB1"/>
    <dbReference type="OMA" id="IHRKDAN"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF9">
        <property type="entry name" value="TAH-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="246"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="286"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="300"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU37647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="946" mass="103673" checksum="60516468A4B31DE1" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEU5</accession>
    <name>C7ZEU5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_51604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lcsJ thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043147.1">
        <property type="nucleotide sequence ID" value="XM_003043101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEU5"/>
    <dbReference type="FunCoup" id="C7ZEU5">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="GeneID" id="9665167"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51604"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51604"/>
    <dbReference type="eggNOG" id="KOG4366">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040660_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZEU5"/>
    <dbReference type="OMA" id="APAWPMD"/>
    <dbReference type="OrthoDB" id="265761at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="26334" checksum="9A1F77DA5C895784" modified="2009-10-13" version="1" fragment="single">RFLRAFVRRLTDSAPNKHLSPRCLFLPAISATRSPALECDYNLHKSNSTYFTDMDMSRGNFCLVLFSKPFNPIPGPNHFTMILGGTTCTWRKEIKPYAPYELWTRILSWDEKWLYVVTHFVKPGVFHPDEYVMQPKKKTSSKKNKEDVELLKAVYASSVARYVFKSNRRTIPPEQALRDAGLLPEDETELAEVEKTRADALAIGRLEAGWDAVHGCLQPTGAALGWYNSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFT4</accession>
    <name>C7ZFT4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_52191</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698924">
        <property type="protein sequence ID" value="EEU37002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042715.1">
        <property type="nucleotide sequence ID" value="XM_003042669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFT4"/>
    <dbReference type="GeneID" id="9664831"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_52191"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_52191"/>
    <dbReference type="eggNOG" id="ENOG502RYF5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044619_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZFT4"/>
    <dbReference type="OMA" id="HDWETFA"/>
    <dbReference type="OrthoDB" id="3466836at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF27">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="32"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU37002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="317" mass="35507" checksum="5C1775218CCDA8C2" modified="2009-10-13" version="1">MYDFIRLETKPTARLCYSFSPATTSTTEQTLVVFVNGLGLPQAGWASTIARLRELSPQKLPAILTYDRFGQGQSVDRDPADEGAADPSHAHDCMSVVRDMRQLIAQIAKDKMNAEEPDNLRIVFVGNSVGCSLIRLYAQEYPNVVAGILFLDSTLTDTDFVSLFPDPDAKSFDPNLPPGVTAESLRDAREKIRQRFHPDVGSQEGLSRRNLFQLLPRADSPPLYKAREAAPYIQVLGHDFEFFAERAEMDLGIPVAVIQIYMNTYWHRYNQGLAKLTMSERSKGPFQVPGAGHFIQADNPSYVAERLHEMLQLLEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZG26</accession>
    <name>C7ZG26_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Short-chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_52180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698924">
        <property type="protein sequence ID" value="EEU36985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042698.1">
        <property type="nucleotide sequence ID" value="XM_003042652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZG26"/>
    <dbReference type="STRING" id="660122.C7ZG26"/>
    <dbReference type="GeneID" id="9664813"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_52180"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_52180"/>
    <dbReference type="eggNOG" id="KOG1014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103010_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZG26"/>
    <dbReference type="OMA" id="HLIHYLA"/>
    <dbReference type="OrthoDB" id="5336600at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF4">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU36985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="24051" checksum="03BEFE6A1BAAA581" modified="2009-10-13" version="1">MAPNSPVALILGAGSNIGQHVGRAFAAKGYTIALAARSLKEEDSTPNQLHIHSDFSDPESVEKVFSTVKSQLGTPGVVVYNAAAVTPNDAKNPLSLDLKAFTRDLAINTTGAFAAAQQAALAFEELPSSASRTFIYTGNFLNDHTIVSLMDLGVGKSATAHFIKCAAEAYASKGFKFYYADERKADGSSASAAIDGAAHGEFYTKLAEGDSQGPWQQTFVKGQGYTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZH64</accession>
    <name>C7ZH64_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_51832</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698927">
        <property type="protein sequence ID" value="EEU36585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042298.1">
        <property type="nucleotide sequence ID" value="XM_003042252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZH64"/>
    <dbReference type="STRING" id="660122.C7ZH64"/>
    <dbReference type="GeneID" id="9669554"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51832"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51832"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_1_1_1"/>
    <dbReference type="InParanoid" id="C7ZH64"/>
    <dbReference type="OMA" id="QLWGGFT"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF53">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="55"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU36585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="502" mass="54555" checksum="E8F538443033D92D" modified="2009-10-13" version="1">MREFSAPLSSLSSFLLTQTIQCSTLAAVPQLKGKIYVPGSDAYDARLKTYYSANAALEPWCMVLPETTQDVSKIAQVISNKKCPFGIRSGAHSAWKGSNGVENGITIDFSYMNATTYDSKKKIASIQPGSNWGRVYEALNEHGVAAVGGRASVVGVGGFTTGGGYSFHSNARGFACDVVANFEVVLSDGRIVNANKNQHPDLWKALKGGSGNLGFVTRVDQCNANQNRSADVVDSNKLWGGFVSFDLSQRDRVFESYIDFAENMHLDPASQLIVSVQYNGKERILISVVSNSDAIPAAPAFDDFLSLPNVSNTLTTGKIADLVPQFTGPTPLGLYANWMTGMATNDIRVMKFVDEKHAEYVEKMKAVAPGSDFSVLVQFQPFTESMVAHSRKAGGNVLGLEDVVADGPALNWLIAVTVDTAENQKKIAPLTLEYRNAINKYATSISANKNWEYLNYALGDQDPIKHYGTESVRYLQAASKKYDPQQVFQKLRASGFKIPGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHR1</accession>
    <name>C7ZHR1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Expansin-like EG45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_42444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698928">
        <property type="protein sequence ID" value="EEU36558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042271.1">
        <property type="nucleotide sequence ID" value="XM_003042225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHR1"/>
    <dbReference type="GeneID" id="9669375"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_42444"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_42444"/>
    <dbReference type="eggNOG" id="ENOG502S9P9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026963_3_1_1"/>
    <dbReference type="InParanoid" id="C7ZHR1"/>
    <dbReference type="OMA" id="EGTSAHW"/>
    <dbReference type="OrthoDB" id="406505at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd22271">
        <property type="entry name" value="DPBB_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.760">
        <property type="entry name" value="Expansin, cellulose-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036749">
        <property type="entry name" value="Expansin_CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF21">
        <property type="entry name" value="EXPANSIN-LIKE PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49590">
        <property type="entry name" value="PHL pollen allergen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988861" description="Expansin-like EG45 domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU36558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="20638" checksum="067FFD6E59B892CF" modified="2009-10-13" version="1">MKFLSLLLAAPALVFARDLSSEVVKGTSTHYGGNLNGGTCSFVSYSLPAGIYGTAFSGSNWNLAGNCGACIEVTGPNGKKIKTMIVDKCPECDKGHLDLFQNTFDAVGGSNGLWWFSMQVRNSNVPVKSLEVSTDGGKSWKGTTRRDYNFFENPSGFGTQTVDVRVTGSTGATIIVKNVSVEPMKETKAGSNFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJ47</accession>
    <name>C7ZJ47_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_101761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698932">
        <property type="protein sequence ID" value="EEU36013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041726.1">
        <property type="nucleotide sequence ID" value="XM_003041680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJ47"/>
    <dbReference type="STRING" id="660122.C7ZJ47"/>
    <dbReference type="GeneID" id="9674004"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101761"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101761"/>
    <dbReference type="eggNOG" id="ENOG502RS70">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_264194_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZJ47"/>
    <dbReference type="OrthoDB" id="5029321at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF82">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="493"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1046"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1057"/>
            <end position="1070"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU36013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1164" mass="131271" checksum="2FAF3D0B91EAF440" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJD4</accession>
    <name>C7ZJD4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_77217</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698933">
        <property type="protein sequence ID" value="EEU35830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041543.1">
        <property type="nucleotide sequence ID" value="XM_003041497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJD4"/>
    <dbReference type="GeneID" id="9673970"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77217"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77217"/>
    <dbReference type="eggNOG" id="ENOG502SQ3E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011409_12_0_1"/>
    <dbReference type="InParanoid" id="C7ZJD4"/>
    <dbReference type="OMA" id="NLWHARE"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="491"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="510"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="522"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU35830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="606" mass="66688" checksum="EEBC593775A6B0FD" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJD8</accession>
    <name>C7ZJD8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclin-D1-binding protein 1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_34917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698933">
        <property type="protein sequence ID" value="EEU35832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041545.1">
        <property type="nucleotide sequence ID" value="XM_003041499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJD8"/>
    <dbReference type="STRING" id="660122.C7ZJD8"/>
    <dbReference type="GeneID" id="9673972"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_34917"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_34917"/>
    <dbReference type="eggNOG" id="ENOG502QZAU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040328_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZJD8"/>
    <dbReference type="OMA" id="WSKTWLK"/>
    <dbReference type="OrthoDB" id="4088536at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026907">
        <property type="entry name" value="GCIP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049317">
        <property type="entry name" value="GCIP-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492">
        <property type="entry name" value="CYCLIN D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492:SF1">
        <property type="entry name" value="CYCLIN-D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13324">
        <property type="entry name" value="GCIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-D1-binding protein 1-like N-terminal" evidence="1">
        <location>
            <begin position="59"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="366" mass="40198" checksum="E1868F7B8DD1473A" modified="2009-10-13" version="1">MAPTDQEAIKALSTLVETARTLLKQLQSVLTEIQRNPSSSSTSDSPSSDIDALALARDSSSLIRAHGTKISLLVINEPFTPSAVATVIRELVKGPIPGLASAAQACETNLYTAVVRKELAYRAQNVLAELEKLLQRVPKDGKVLSGGNRDGGKGSLALTGMLWSACDDVIGLATMGVGGFFVKKAEQWRDTLKDVMEEMKEWGDEEPDDDEDEDEVDDLADQLGDASISKQDMLDDLMSSGGTIPKSDPDKIRPRLDSTLKRLRMIVLLYQAISKRRFKKLPKDTTKSDMPQRLDKTANVLEGLPDEFGDLAGAFYDLDPEEIDRLMEECFNSAAGVGEVLKLGWQGEKDEFTDWIDKFQVEVKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKB3</accession>
    <name>C7ZKB3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_88750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698938">
        <property type="protein sequence ID" value="EEU35496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041209.1">
        <property type="nucleotide sequence ID" value="XM_003041163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKB3"/>
    <dbReference type="STRING" id="660122.C7ZKB3"/>
    <dbReference type="GeneID" id="9675845"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88750"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88750"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_13_1_1"/>
    <dbReference type="InParanoid" id="C7ZKB3"/>
    <dbReference type="OMA" id="VCPWATD"/>
    <dbReference type="OrthoDB" id="5371740at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU35496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="328" mass="35870" checksum="2AE1D1D19F54E5A6" modified="2009-10-13" version="1">MAEIKLCLDALEAVKGQVVVMTGGSQGIGAATVSMLYKRGAHVYFGDSNEIRGRELVDSLRSNTPNTGGSVHFQKLDVRDYRSQLQLFQTPYKEKGRVDVAVSCAAVTEPSGWFGTDDLNLETVMMEPQPLKDAIEINLTSVVLFCRIALAYMGVKDDSKVPDNITFPTSKSIVLVSSIAGVVEQTGLFSYSSAKHGIIGLMRSLRAWAPAKYNVRINAICPWATDTQMMKTVRSAWLEHGLPINTPDEVSQFILQLATDKTLNGRCVVVGGGRGFDTEGIGNTMSEWFGPELTREFLRAQKVLGMGDDWSSTQKGGKRRDMLHLPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKM7</accession>
    <name>C7ZKM7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aldose 1-epimerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_97055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldose epimerase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698940">
        <property type="protein sequence ID" value="EEU35435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041148.1">
        <property type="nucleotide sequence ID" value="XM_003041102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKM7"/>
    <dbReference type="STRING" id="660122.C7ZKM7"/>
    <dbReference type="GeneID" id="9675709"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_97055"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_97055"/>
    <dbReference type="eggNOG" id="KOG1604">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031753_0_1_1"/>
    <dbReference type="InParanoid" id="C7ZKM7"/>
    <dbReference type="OMA" id="VWDVEPF"/>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000014">
        <property type="entry name" value="Aldose 1-epimerase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF6">
        <property type="entry name" value="1-EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU35435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="43056" checksum="811F4BAC13396FEA" modified="2009-10-13" version="1">MRFNKGEKGPDKDGKYWISGDGIEAAFIPYGASITNLLVNDQYGVSRDVVAGFDNATHYSIDEAHPHFGGVPGRYANRIRNSTFEIDGKKYKVKPNDNPTPEAPEGADTLHGGPDGWDYRNFTVVSHTKSSITFSIVDPDGKEGFPGEVVSYVTYTLTGRDWDIKIVALATTKKTPIMLTSHTYWNLDGFSNNETSTVSNHTLHMPYSGQRVAVDNILIPNGDIIPNKKGSANDFWSEPKHIGDQENNSELKGNCGFNCTGYDNCYIVSREQLGKYDWRTEGPVATLSSSWSGIQLDIYTDQDAFQFYSCTQQNGAIPLKKTQGLHDSSDFPRTIPKYGCVVMEVQDWIDGINHPEWMRDRKQLFEPGGDPYVLQARYSFSLKGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLB1</accession>
    <name>C7ZLB1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_72904</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698944">
        <property type="protein sequence ID" value="EEU35205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040918.1">
        <property type="nucleotide sequence ID" value="XM_003040872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLB1"/>
    <dbReference type="GeneID" id="9675206"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_72904"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_72904"/>
    <dbReference type="eggNOG" id="ENOG502RXW6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033263_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZLB1"/>
    <dbReference type="OMA" id="LHYFARF"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36459:SF1">
        <property type="entry name" value="FATTY ACID DESATURASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36459">
        <property type="entry name" value="ORF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="3">
        <location>
            <begin position="157"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU35205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="450" mass="52557" checksum="106A02D926813EC6" modified="2009-10-13" version="1">MDKYIVFDRQLTKADLVVLQSLTEDLREHTRKEGRDGAAKANGKTLNASTPDADAKASNDGTSPNQHANQLSYEEAVRHLEALNNPNDAHFEPTIINNLDLDQIKLPPVLDKLLLRPFIRIARSLVRVETDVIMLTHLLLYVFTSIPSAVFLFYNFTWIHGVLHFVMQISYMGTYTLMMHQHIHMRGILHKRLALFDHIFPYILDPLMGHTWNSYFYHHVKHHHIEGNGPNDLSSTIRYQRDSLLHFLHYTGRFFFFIWAELPYYFLRKGRASLAFKAAFWELSTYASLYTLYRINPQATVFVFLIPLFLLRLGLMAGNWGQHAFVDADEPDSDYRSSITLIDVASNRHCFNDGYHTSHHLNPMRHWREHPVSFLKTKHIYASQQALVFHDIDYMMVTVSLLTKNYKRLAECLVPIGSQMSLNMDERVKLLQRHTRRFSEEEIKQKFKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLE6</accession>
    <name>C7ZLE6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_53235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698944">
        <property type="protein sequence ID" value="EEU35182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040895.1">
        <property type="nucleotide sequence ID" value="XM_003040849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLE6"/>
    <dbReference type="FunCoup" id="C7ZLE6">
        <property type="interactions" value="160"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZLE6"/>
    <dbReference type="GeneID" id="9675225"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_53235"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_53235"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_1"/>
    <dbReference type="InParanoid" id="C7ZLE6"/>
    <dbReference type="OMA" id="VEAMTHI"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU35182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="259" mass="26895" checksum="094A0EAA35C6A836" modified="2009-10-13" version="1">MAVDTLSLAGKVAIVTGSGRENGIGAGIALALARNGAAVTINYVSDSVTARANALAEKITSIGGRVAVVKTTVDTPEGAKFLVQETLKAFGTDHIDILVNNAGWGTASSSLDMKAEDITRTFDVNVKGPIFVAQATVPHMPSGGRVINITSTASKLGQADIPIYGASKAALDSLTWSWAKEWGRSHGITVNSVAPGPVATDIVPPELQEELHREHVNNTRAAGRVGTIEDIGDAVLLLVSEKSRWITGQYISVSGGVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLN2</accession>
    <name>C7ZLN2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_94888</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698946">
        <property type="protein sequence ID" value="EEU35059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040772.1">
        <property type="nucleotide sequence ID" value="XM_003040726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLN2"/>
    <dbReference type="FunCoup" id="C7ZLN2">
        <property type="interactions" value="247"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZLN2"/>
    <dbReference type="GeneID" id="9679207"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94888"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94888"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_16_1_1"/>
    <dbReference type="InParanoid" id="C7ZLN2"/>
    <dbReference type="OMA" id="GPKFEAK"/>
    <dbReference type="OrthoDB" id="9992527at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF7">
        <property type="entry name" value="ZINC BINDING OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="3"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU35059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="336" mass="35811" checksum="DDAC3F75E59D84EA" modified="2009-10-13" version="1">MGGRVQDNVPVPTITSNEILVKVKAVALNPTDFKHLDVISPPGSTIGCDYAGVVDKVGDAAAATWKVGDRVAGAVHGGLFPDKGAFAEYLKVESDLAWKVPDNVSDTDATTYGVSAVTAMLNINVRHGIPFVDGKTAAPRNETIFIYAGSTSAGLYHIQLAKAAGCTVVTTASPHSFDLVKKYGADAVYNYRSPTVVEEIVKDYPDMTKAVDCFSEGKSTTVCAEVIKKKGGKVITLLPNGKSKFPNVTYDLVMAYTALGHPFQWLPPIGPKFEVQPADREGLVRFYSVLPQVLHIVKPIPTIEEKAGFDGILEGLDKLRGGKVSGGKLVVSFGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLU0</accession>
    <name>C7ZLU0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_37485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698947">
        <property type="protein sequence ID" value="EEU35019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040732.1">
        <property type="nucleotide sequence ID" value="XM_003040686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLU0"/>
    <dbReference type="STRING" id="660122.C7ZLU0"/>
    <dbReference type="GeneID" id="9679134"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_37485"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_37485"/>
    <dbReference type="eggNOG" id="ENOG502SH5I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054423_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZLU0"/>
    <dbReference type="OMA" id="WYLANTF"/>
    <dbReference type="OrthoDB" id="5416609at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="134" mass="14405" checksum="030517EE62B37993" modified="2009-10-13" version="1" fragment="single">QTTIAALMRGREPMALGVNAVFPKARFIHAASVGDIKRHHVDGQCTMLLVDSVVNSGKTLMQFIDHVRGLNANIRIVVVAGVVQAEVVVETHPLAKLMGRHGASLVALRLSENKFTGTKGTDTGNRLFNTTHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZM88</accession>
    <name>C7ZM88_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_102243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698950">
        <property type="protein sequence ID" value="EEU34872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040585.1">
        <property type="nucleotide sequence ID" value="XM_003040539.1"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZM88"/>
    <dbReference type="GeneID" id="9678998"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102243"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102243"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001248_5_1_1"/>
    <dbReference type="InParanoid" id="C7ZM88"/>
    <dbReference type="OMA" id="TEGNYNT"/>
    <dbReference type="OrthoDB" id="5210233at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13245">
        <property type="entry name" value="AAA_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="2">
        <location>
            <begin position="126"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1483"/>
            <end position="1505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU34872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1505" mass="167670" checksum="13898500C9F33479" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMP4</accession>
    <name>C7ZMP4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_87019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698957">
        <property type="protein sequence ID" value="EEU34708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040421.1">
        <property type="nucleotide sequence ID" value="XM_003040375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMP4"/>
    <dbReference type="STRING" id="660122.C7ZMP4"/>
    <dbReference type="GeneID" id="9678858"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87019"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87019"/>
    <dbReference type="eggNOG" id="ENOG502S9YF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033464_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZMP4"/>
    <dbReference type="OMA" id="AICIKCH"/>
    <dbReference type="OrthoDB" id="2311180at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="55854" checksum="A8F2A70BB844C19B" modified="2009-10-13" version="1">MQTCGCGKEKTDTTGSLLSLLIALVFLVTRNDNETQLRFISLKLLHLHDILTLYNNPSNASLIPMQSRISTRAATPRRVEQIRIYIDNSNVWIQGQRTSAEKRGLPEKLDPTWRFDAGKLKNVLTQNCGLPADEDVQAIVDLYGSTPHEIDATWRAIESCDVRVHTFERSSWTKREKKSTLKSSRPRTFIIVSGDKDLIRAVLRIAKREFQVHVWSWRNGISAAYTQPKEECRHLMMDRELIEVHFLDDFMDKFSFHEEVFDPKKSAIPDNSIVILEPSINRDIINQVLENLRISYRLHHLQRRGVSEKDLVIILICELDHETHTEIFQDMREELKRYNLRAMTYFEYNNSASRPQNPKGKFITPNPFDPLRKANGIDSKSGQDNDGFTPVNNGRKKQNKRLKAEQKLVYNRCVWRLYCSEGTRCKYGHTIEETATFEACGTRKAKRYKFCSNGKDCFKKTCNYAHKWDELLCPTCDKTGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZN59</accession>
    <name>C7ZN59_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_88839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698963">
        <property type="protein sequence ID" value="EEU34542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040255.1">
        <property type="nucleotide sequence ID" value="XM_003040209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZN59"/>
    <dbReference type="GeneID" id="9678087"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88839"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88839"/>
    <dbReference type="HOGENOM" id="CLU_2050246_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZN59"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU34542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="120" mass="14048" checksum="6B191BD2A4CB0FEB" modified="2009-10-13" version="1">MSVYWGVISNRHQDFQVRQRSLTQTVPTTSTHSPWHFVQRRDLKPGNGIEEAAAYFRTELIQAVEEKEWYVFGYFPKTGGWRKYYASVPVALVLKCRLDVSQKRWLACKGLIQKQPKDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNX0</accession>
    <name>C7ZNX0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_72215</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039982.1">
        <property type="nucleotide sequence ID" value="XM_003039936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNX0"/>
    <dbReference type="FunCoup" id="C7ZNX0">
        <property type="interactions" value="425"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZNX0"/>
    <dbReference type="GeneID" id="9677707"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_72215"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_72215"/>
    <dbReference type="eggNOG" id="KOG0251">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014248_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZNX0"/>
    <dbReference type="OMA" id="AWTIVFK"/>
    <dbReference type="OrthoDB" id="44015at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16988">
        <property type="entry name" value="ANTH_N_YAP180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.150:FF:000004">
        <property type="entry name" value="ENTH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000025">
        <property type="entry name" value="ENTH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
        <property type="entry name" value="ANTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014712">
        <property type="entry name" value="ANTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045192">
        <property type="entry name" value="AP180-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013182">
        <property type="entry name" value="DUF1720"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951">
        <property type="entry name" value="CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951:SF5">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN LAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08226">
        <property type="entry name" value="DUF1720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ENTH" evidence="8">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="276"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="445"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="487"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="316"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="487"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="562"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU34269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="634" mass="69600" checksum="9518308486B8F32C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPA2</accession>
    <name>C7ZPA2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_85648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040026.1">
        <property type="nucleotide sequence ID" value="XM_003039980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZPA2"/>
    <dbReference type="GeneID" id="9677665"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85648"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85648"/>
    <dbReference type="HOGENOM" id="CLU_850178_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZPA2"/>
    <dbReference type="OrthoDB" id="10623342at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="327" mass="36726" checksum="365F00385D1106DE" modified="2009-10-13" version="1">MALASMAGSQLAWTVHSSMGALDLLELARPKQQKHPEPIQRRQDHDEEIGYITLQVLYPDEEFENPQDEDKRLLPTATYHENDPSRVFLPEPLRTMTHLRPSGIASLRLAPRVLITSQEPERLSPSTSWSETELVLLFVPIDPSPGSSSVSEVSCAMFPTVWPLSEGLRDRARGTDGMILRFIGPIRRRDASGALSIYDALGVFVSFAAPVAECLGWRLRRSGQEVSPFATGRHFEASNVYRERFEALAMAPFSLRDHDHKEAHGGTSTPRKENEYPDPRGIHISDLEPRFPTVDRRVPRAPKPPPFPLLSCGLDDRSTKYRTKLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQ17</accession>
    <name>C7ZQ17_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_88822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698978">
        <property type="protein sequence ID" value="EEU33894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039607.1">
        <property type="nucleotide sequence ID" value="XM_003039561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQ17"/>
    <dbReference type="GeneID" id="9667126"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88822"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88822"/>
    <dbReference type="HOGENOM" id="CLU_1639393_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZQ17"/>
    <dbReference type="OrthoDB" id="3235083at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU33894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="163" mass="17904" checksum="4FB8699643A11DB2" modified="2009-10-13" version="1">MCSLDPDAAQPGFTIFAATQTTATYLASTYAIDPSPSAEAPWTVINFGAQSNKIVDIQPLVLGFQAYTPRSTPGAGNGIAFHQFQNLNDPCLDKDRQIILPDIAFRQVFCKETMLSNPRRYLLSILAVSQDNELYVIDGERDPKNFGLPTFRYSGLPIRGDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQB0</accession>
    <name>C7ZQB0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 105</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_106608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698987">
        <property type="protein sequence ID" value="EEU33788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039501.1">
        <property type="nucleotide sequence ID" value="XM_003039455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQB0"/>
    <dbReference type="GeneID" id="9667024"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_106608"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_106608"/>
    <dbReference type="eggNOG" id="ENOG502QV67">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038720_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZQB0"/>
    <dbReference type="OMA" id="WHYHQGV"/>
    <dbReference type="OrthoDB" id="540611at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052043">
        <property type="entry name" value="PolySaccharide_Degr_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886:SF9">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU33788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="361" mass="41753" checksum="33F53B53953A956C" modified="2009-10-13" version="1">MADSWIRNNHETQRAYWYGRGVVYEGYEAAIELTKNETLSEWYRSQIDDLVIAPNGTIVNYDMTRYSLDNYRIALNLLYWYQKTGEEKYKTGADFIRDRLNQHPRTPTGGFWHRSPTYPDQMWLDGIFMADSFYAVWTSLFDAKNTTAWNDIVLQWDKIQEVTIEKETGLPVHGFDESKTAVWADPETGASPIVWSRAVGWYIWSLIEVLDVFPKSHPGYKRLRTYYKKLATALVKAQDPESHGWWLVMNKQYAGVEGNYLESSASAMFTYGLLAGLRRGYLDERTFAKPATRAYNHLVNDFVTEHANGTITWEGTVEVGSLNSDASFKYYTEVPIVPDDTRGVGPFMMALYEWERRTTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZR32</accession>
    <name>C7ZR32_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_89395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699027">
        <property type="protein sequence ID" value="EEU33528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039241.1">
        <property type="nucleotide sequence ID" value="XM_003039195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZR32"/>
    <dbReference type="GeneID" id="9666763"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89395"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89395"/>
    <dbReference type="eggNOG" id="ENOG502RNZN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057190_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZR32"/>
    <dbReference type="OMA" id="YGLWTTW"/>
    <dbReference type="OrthoDB" id="2823490at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU33528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="324" mass="37503" checksum="AE75778D6D216FD6" modified="2009-10-13" version="1">MSLSQLPRETRQKIFDLAIGSPATPPASPSVSQHARSRGIRHRGIWCIQPENPALSLLLVNRQFNDEVRKVLGFMTADYYVDIMFVKNYGLFPTWHIPILPRTKHIKSINATFRLFDPTDGLDPRFRDSMDFSGGDGGPEGAAWTFYYLLIDVLQKGPGDLGYFDEYFIEDITINILEPTDGAAHKSIACGDRELELGHKPRRRFSRKFFSDETIKPEERLAMYIANNLGTILSLDYHTTNYGMIVWEHVMGGIVLNLSGSEYRQFGMEELIEGHRIRDWGMTPEYIAGRKEKYERWRYWLDERRRRVKGDLELNGKRPVSYIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZR81</accession>
    <name>C7ZR81_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_89445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699041">
        <property type="protein sequence ID" value="EEU33477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039190.1">
        <property type="nucleotide sequence ID" value="XM_003039144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZR81"/>
    <dbReference type="GeneID" id="9666711"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89445"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89445"/>
    <dbReference type="HOGENOM" id="CLU_671012_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZR81"/>
    <dbReference type="OrthoDB" id="5267677at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU33477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="410" mass="45670" checksum="87B5EDF0E701A70E" modified="2009-10-13" version="1">MAKNMRIPPTKGTMKDPNPRIRHYGATTAHGIEAIGTETALLVARDREKSAITPTIIDSDPKGQITRTDKEEGGTKTETGNEEMTEAALANGGEEPRRRNRNDSLSEEGAGESDKSTAYYAEITEREEDSYLVIEAEERRYINFAIDDGQVIEAIRRPDFRRVTNITKSATFDFYLPGTIRGKEVKAHFTVTADIVDQLTPHLLLGIGFLYEHGAKVDFVYPSVSFRSAHSIIIRGEIFKKRISPLNRVVKSAYTVTVKKGETAFIPVTYKNLPATHRSDGSKEAFYFQGKDKRFFDSTIDRSTPRIVIFHNTDGKDIRIHRRQLIGHISNYEGNETTNFIASGSGTVDFPGIIGKDFRPGEEVENVLVTGTLPMTTTELEETIDKDNPIRVDAGLPNYGISRPKGIPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZR97</accession>
    <name>C7ZR97_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_56630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699050">
        <property type="protein sequence ID" value="EEU33461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039174.1">
        <property type="nucleotide sequence ID" value="XM_003039128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZR97"/>
    <dbReference type="STRING" id="660122.C7ZR97"/>
    <dbReference type="GeneID" id="9666696"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_56630"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_56630"/>
    <dbReference type="HOGENOM" id="CLU_2838158_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZR97"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU33461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="66" mass="7295" checksum="CF5788E7CBD3006B" modified="2009-10-13" version="1" fragment="single">IASIIGTNVSFITGKSLADVSVALKISWLSRGVTKRVKDVIYCILRIFSINMPFLYSKGINIFVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-04-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>H6D5E7</accession>
    <name>H6D5E7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Cytochrome c oxidase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">cox3</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="12"/>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="2" last="14">
            <title>Comparative analysis of Fusarium mitochondrial genomes reveals a highly variable region that encodes an exceptionally large open reading frame.</title>
            <authorList>
                <person name="Al-Reedy R.M."/>
                <person name="Malireddy R."/>
                <person name="Dillman C.B."/>
                <person name="Kennell J.C."/>
            </authorList>
            <dbReference type="PubMed" id="22178648"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2011.11.008"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
            <strain evidence="12">MpVI</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:11437"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome c oxidase subunit 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="JN041209">
        <property type="protein sequence ID" value="AEJ72902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H6D5E7"/>
    <dbReference type="FunCoup" id="H6D5E7">
        <property type="interactions" value="224"/>
    </dbReference>
    <dbReference type="STRING" id="660122.H6D5E7"/>
    <dbReference type="InParanoid" id="H6D5E7"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01665">
        <property type="entry name" value="Cyt_c_Oxidase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000082">
        <property type="entry name" value="Cytochrome c oxidase subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.80:FF:000002">
        <property type="entry name" value="Cytochrome c oxidase subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.80">
        <property type="entry name" value="Cytochrome c oxidase, subunit III, four-helix bundle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024791">
        <property type="entry name" value="Cyt_c/ubiquinol_Oxase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033945">
        <property type="entry name" value="Cyt_c_oxase_su3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035973">
        <property type="entry name" value="Cyt_c_oxidase_su3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013833">
        <property type="entry name" value="Cyt_c_oxidase_su3_a-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11403:SF7">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11403">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00510">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81452">
        <property type="entry name" value="Cytochrome c oxidase subunit III-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="199"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Heme-copper oxidase subunit III family profile" evidence="11">
        <location>
            <begin position="10"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEJ72902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="269" mass="30418" checksum="14DC90327E8CDB61" modified="2012-04-18" version="1">MTNLIRSNFQDHPFHLVSPSPWPLYTSISLFSLTVNGALSMHLFNNSYITFYLSLITLIASMSFWFRDIISEGTYLGNHTLAVQKGLNLGVILFIVSEGLFFVAIFWAFFHSALTPTVELGAQWPPMGIEPVNPFELPLLNTVILLSSGATITYAHHSLIKGERKGALYGSIFTVLLALIFTFFQGVEYSVSSFTISDGVFGTCFFFGTGFHGFHVIIGTIFLSVALWRIYSYHLTDHHHLGYEAGILYWHFVDVVWLFLYVSMYYWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIH9</accession>
    <name>C7YIH9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_30551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054521.1">
        <property type="nucleotide sequence ID" value="XM_003054475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIH9"/>
    <dbReference type="STRING" id="660122.C7YIH9"/>
    <dbReference type="GeneID" id="9664644"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_30551"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_30551"/>
    <dbReference type="eggNOG" id="ENOG502RU3A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002712_0_0_1"/>
    <dbReference type="InParanoid" id="C7YIH9"/>
    <dbReference type="OMA" id="RRPRMDW"/>
    <dbReference type="OrthoDB" id="5402622at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038769">
        <property type="entry name" value="MTC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38426">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38426:SF1">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1177"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1203"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="845"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="720"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="908"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="933"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="959"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU48808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1224" mass="137233" checksum="9CD553B03D6C6814" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIJ1</accession>
    <name>C7YIJ1_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_98956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053815.1">
        <property type="nucleotide sequence ID" value="XM_003053769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIJ1"/>
    <dbReference type="STRING" id="660122.C7YIJ1"/>
    <dbReference type="GeneID" id="9676451"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_98956"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98956"/>
    <dbReference type="eggNOG" id="ENOG502S6IQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029955_1_0_1"/>
    <dbReference type="InParanoid" id="C7YIJ1"/>
    <dbReference type="OMA" id="MLWLRTR"/>
    <dbReference type="OrthoDB" id="5377213at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU48102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="470" mass="51269" checksum="AD83711047CD9C2B" modified="2009-10-13" version="1">MAQTSPPLPGHFHTGHGHQHAKITKARSRQAVKPILKKLHSGHSYSHSEKNSLDLNRGWDEQGQFGYSSYTTSGGDEDSHGSYTAGASTLTTPVTRSARDVSFSLSATDLSSGGARSNKYSHARSTSGTSHASIATSTSGGRNGSFVHPFQQTPRTSTPPLSYANSLASLENPNGPRDYSPTITEDDDDIEPQNLQSSGRSYPLPHSGSRPRRPSLASQRTSSLSDINQPLRVTTNGRSTPGISSRKPHNIVTRSRSDLHLNTGSTSALDSASSATPPAGSFISPQMIAASTSSSAMSPLRSSLDMGGFRLRSRSEVDTATRQEHVREARRKFEEKEKAKEEKYAREQIRKQERAESREAHRFNKHGRKGSFGASRISCDRASSTDIRPSMSRKNTGTGLGLGLSTENEKVDFASRGYDTVTTAQTPRARTDDVHFESSRRNNTAKRKTTGAWTAFVLWLRTRLLKLGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIW8</accession>
    <name>C7YIW8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA repair exonuclease rad1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_98993</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054591.1">
        <property type="nucleotide sequence ID" value="XM_003054545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIW8"/>
    <dbReference type="STRING" id="660122.C7YIW8"/>
    <dbReference type="GeneID" id="9676512"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_98993"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98993"/>
    <dbReference type="eggNOG" id="KOG3194">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035332_0_0_1"/>
    <dbReference type="InParanoid" id="C7YIW8"/>
    <dbReference type="OMA" id="WSQAYKF"/>
    <dbReference type="OrthoDB" id="337581at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003011">
        <property type="entry name" value="Cell_cycle_checkpoint_Rad1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003021">
        <property type="entry name" value="Rad1_Rec1_Rad17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02144">
        <property type="entry name" value="Rad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01245">
        <property type="entry name" value="RAD1REC1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01246">
        <property type="entry name" value="RAD1REPAIR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU48878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="35330" checksum="F880FC869FC01834" modified="2009-10-13" version="1">MATEAQPIFRAVATSTRPLFQLLKCINFAPRVHVQITDEGVRFSTDHARVMQGVAFLDKGLFSSFTANVPSQEGPDPPDLPSFQLSLNSILEVLQIFGAVDVATRAQKAEQDPYRSNLRNYRPDAFSNQTLGISGTCTLLYNEEGDPFKITIEESGVKTTASLTTYLPEIPDEIPFDRNDLAFKMIMQSRTLLDSLAEISPTAPTKLTITATKTAPFLSLAGVGDLGSSGVDFARGRDLIESLGIRERWSQCYKFDFIKNSSEAMRIATKVSLRGDGQGVLSLQFMVEMEGGKQSYLDFKFIPFIQHDEDDDEESAEEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJD6</accession>
    <name>C7YJD6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_75641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054673.1">
        <property type="nucleotide sequence ID" value="XM_003054627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJD6"/>
    <dbReference type="STRING" id="660122.C7YJD6"/>
    <dbReference type="GeneID" id="9676594"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75641"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75641"/>
    <dbReference type="eggNOG" id="ENOG502RQIH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_526837_0_0_1"/>
    <dbReference type="InParanoid" id="C7YJD6"/>
    <dbReference type="OMA" id="DERIDHT"/>
    <dbReference type="OrthoDB" id="5382699at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="397"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU48960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="542" mass="59372" checksum="AE33A75C8BCF7D7A" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJT0</accession>
    <name>C7YJT0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_90586</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU49030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054743.1">
        <property type="nucleotide sequence ID" value="XM_003054697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJT0"/>
    <dbReference type="GeneID" id="9663973"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90586"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90586"/>
    <dbReference type="eggNOG" id="ENOG502QU2T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_1_1_1"/>
    <dbReference type="InParanoid" id="C7YJT0"/>
    <dbReference type="OMA" id="TAPNYWH"/>
    <dbReference type="OrthoDB" id="2310150at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU49030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="335" mass="37720" checksum="BA8DDBEDC6D3A50B" modified="2009-10-13" version="1">MANSTNKPRVILGLMTFGPPGSEPNGARITSLSDFKACLDYFQGEGYAEIDTARIYVDGKQEAFTREAEWQQRGLKVATKVYPREPGFHTAAKLRSIFETSLKELGADSIDIFYLHAPDRSVPFAETLEAVNDLYNEGKFRQLGLSNYAAWEVSELWNIANERGYVKPTVYQAMYNAITRDIDTELVPCCRKYGITIIAYNPLAGGVLSGKYKSTDIPSEGRFSSINDRQGQLYRDRFFKDSTFEALRYIEPVVQKHNLTLVEVAFRWVIHHGLLKFNGVGEGSNDGILVGVSSLQQLKDNLDNIYKGPLPEEVVQTLDEAWINITKATSATYWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7YK50</accession>
    <name>C7YK50_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_31103</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054099.1">
        <property type="nucleotide sequence ID" value="XM_003054053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YK50"/>
    <dbReference type="STRING" id="660122.C7YK50"/>
    <dbReference type="GeneID" id="9676726"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_31103"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_31103"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_27_0_1"/>
    <dbReference type="InParanoid" id="C7YK50"/>
    <dbReference type="OMA" id="EMIPGPT"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF5">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0349">Heme</keyword>
    <keyword evidence="8 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU48386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="60986" checksum="05CFC4897E796D71" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7YK93</accession>
    <name>C7YK93_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Molybdopterin synthase sulfur carrier subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Common component for nitrate reductase and xanthine dehydrogenase protein G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Molybdenum cofactor synthesis protein 2 small subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Molybdenum cofactor synthesis protein 2A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Sulfur carrier protein MOCS2A</fullName>
            <shortName evidence="8">MOCS2A</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cnxG</name>
        <name evidence="9" type="ORF">NECHADRAFT_98688</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by UBA4. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="8">C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of UBA4, then thiocarboxylated (-COSH) via the rhodanese domain of UBA4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the MoaD family. MOCS2A subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054121.1">
        <property type="nucleotide sequence ID" value="XM_003054075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YK93"/>
    <dbReference type="STRING" id="660122.C7YK93"/>
    <dbReference type="GeneID" id="9664127"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_98688"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98688"/>
    <dbReference type="eggNOG" id="KOG3502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1610839_0_0_1"/>
    <dbReference type="InParanoid" id="C7YK93"/>
    <dbReference type="OMA" id="ILEERYC"/>
    <dbReference type="OrthoDB" id="5595860at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990133">
        <property type="term" value="C:molybdopterin adenylyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990140">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030366">
        <property type="term" value="F:molybdopterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04457">
        <property type="entry name" value="S1_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00754">
        <property type="entry name" value="Ubl_MoaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000025">
        <property type="entry name" value="40S ribosomal protein S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03051">
        <property type="entry name" value="MOCS2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044672">
        <property type="entry name" value="MOCS2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028887">
        <property type="entry name" value="MOCS2A_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_eS28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33359">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE SULFUR CARRIER SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33359:SF1">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE SULFUR CARRIER SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="modified residue" description="1-thioglycine; alternate" evidence="8">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycyl adenylate; alternate" evidence="8">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU48408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="195" mass="21195" checksum="F37E90D29FEA38A9" modified="2009-10-13" version="1">MDASKQPVKLVKVTRVLGRTGSRGGVTQVRVEFMDDQSRSIIRNVKGPVREDDILCLLESERTASARYGADIVILQFRFTGTQTSFYNSHNSTGTPTSTMASAPKPPPGHFNVLYFATASSFTGKDYDAVPAAMSLKQLFAELELRYPGIKAKILDSCLVTVNLDYVELSSEEGVDDTVIQEADEVAIIPPVSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7YKK5</accession>
    <name>C7YKK5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_98745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054180.1">
        <property type="nucleotide sequence ID" value="XM_003054134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YKK5"/>
    <dbReference type="FunCoup" id="C7YKK5">
        <property type="interactions" value="978"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YKK5"/>
    <dbReference type="GeneID" id="9676800"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_98745"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98745"/>
    <dbReference type="eggNOG" id="KOG2884">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033293_1_0_1"/>
    <dbReference type="InParanoid" id="C7YKK5"/>
    <dbReference type="OMA" id="QMSMQDQ"/>
    <dbReference type="OrthoDB" id="1731724at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01452">
        <property type="entry name" value="VWA_26S_proteasome_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000005">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3990:FF:000001">
        <property type="entry name" value="26S proteasome regulatory subunit S5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="5"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="234"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU48467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="293" mass="31541" checksum="5F65D2EB37C1B52F" modified="2009-10-13" version="1">MVLEAVMVVVDNSESSRNGDYQPTRFDSQVDAVNITFQTITQGNPESSVGLMSMGGKGPEVLVTLTTEQGKILEGLHRTKKKIGGSSHLKTGIQVAALALKHRQNRSQKQRIIVFVCSPIEESEKELTQLAKKMKKANVTIDFVLFGDLDDDTTQKKLQLFIDTVKTSEGSHLVVIPPSPKLLSDQLISTPILLGENAGGSSGAGGAGGSNEEFEFGFDPAMEPELALALRMSMEEEKARQEKAAREEEEAAKKASLEGVKEEDESGEGSGSNDKKGQDKGDKKGDGDKMDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C7YKM3</accession>
    <name>C7YKM3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">NECHADRAFT_57333</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054188.1">
        <property type="nucleotide sequence ID" value="XM_003054142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YKM3"/>
    <dbReference type="FunCoup" id="C7YKM3">
        <property type="interactions" value="1047"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YKM3"/>
    <dbReference type="GeneID" id="9676810"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_57333"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_57333"/>
    <dbReference type="eggNOG" id="KOG2784">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025086_2_0_1"/>
    <dbReference type="InParanoid" id="C7YKM3"/>
    <dbReference type="OMA" id="QIEGWVM"/>
    <dbReference type="OrthoDB" id="238316at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2320:FF:000001">
        <property type="entry name" value="phenylalanine--tRNA ligase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2330:FF:000002">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000028">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003210">
        <property type="entry name" value="PRK04172.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="230"/>
            <end position="505"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015409"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEU48475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="512" mass="57948" checksum="F5EC105205E7A5F9" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLN7</accession>
    <name>C7YLN7_FUSV7</name>
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        <recommendedName>
            <fullName evidence="10">Seipin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_5671</name>
    </gene>
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        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
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            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YLN7"/>
    <dbReference type="STRING" id="660122.C7YLN7"/>
    <dbReference type="GeneID" id="9663780"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_5671"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_5671"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23995">
        <property type="entry name" value="Seipin_BSCL2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009617">
        <property type="entry name" value="Seipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212">
        <property type="entry name" value="BERNARDINELLI-SEIP CONGENITAL LIPODYSTROPHY 2 HOMOLOG BSCL2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212:SF0">
        <property type="entry name" value="SEIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06775">
        <property type="entry name" value="Seipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
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    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
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            <end position="37"/>
        </location>
    </feature>
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        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
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            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="232"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU47301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="26063" checksum="D72C0841DE056E57" modified="2009-10-13" version="1" fragment="single">RIVTSKPVQRAFVNSVLLVSGAVILFCTAAIASALFFQNFLPHEVVTMPVHLQYGYSQQEYDVSLSLTMPRSNPNVERGNFMISLHMLDSKPDFELQAKAGQHAAEHGGFGTTNILFSSRRPALFPYVDPFVSLASRVLFLAYHLFAPGSSSSTMMIPLAERVWFSKGSMVPKSAYIEVEAGQTIQIYHAALQLTAQLRGLRWLMVHYRISTFIAFTFLFWICEIIFMAVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLR8</accession>
    <name>C7YLR8_FUSV7</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_99569</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052534.1">
        <property type="nucleotide sequence ID" value="XM_003052488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YLR8"/>
    <dbReference type="GeneID" id="9663800"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_99569"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_99569"/>
    <dbReference type="eggNOG" id="ENOG502R2UZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007593_1_1_1"/>
    <dbReference type="InParanoid" id="C7YLR8"/>
    <dbReference type="OMA" id="WEMLSSH"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002987384" evidence="3">
        <location>
            <begin position="18"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="709"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="772"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="596"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="488"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="796"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="819"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU46821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="868" mass="94146" checksum="DC4F4F5E55481F59" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLY3</accession>
    <name>C7YLY3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_91827</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47356.1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_31_0_1"/>
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    <dbReference type="OMA" id="AAGNCFE"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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    </dbReference>
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        <property type="entry name" value="Polyketide synthase dehydratase"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
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        <property type="entry name" value="PKS_dehydratase_sf"/>
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        <property type="entry name" value="PKS_DH"/>
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        <property type="entry name" value="PKS_DH_N"/>
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        <property type="entry name" value="PKS_KR"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
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    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
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        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF23114">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PKS_ER"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="7">
        <location>
            <begin position="1"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="8">
        <location>
            <begin position="930"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="930"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1087"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="6">
        <location>
            <position position="962"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="6">
        <location>
            <position position="1152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU47356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2355" mass="258610" checksum="238780F3981C4986" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7YM35</accession>
    <name>C7YM35_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_77746</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053097.1">
        <property type="nucleotide sequence ID" value="XM_003053051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YM35"/>
    <dbReference type="FunCoup" id="C7YM35">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YM35"/>
    <dbReference type="GeneID" id="9671120"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77746"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77746"/>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076142_0_1_1"/>
    <dbReference type="InParanoid" id="C7YM35"/>
    <dbReference type="OMA" id="CDMLDRV"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="127"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU47384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="197" mass="22351" checksum="36713AB81C9E4B54" modified="2009-10-13" version="1">MATQYEVEHNVKFAEPRRSGRRVDMASFFSLLNQLSEPSGDQTPQHNPHATPTPVDTAALFRLLQDQLQTLHVTAPTEGNREFLESLISSLEDDIHDPPTRLRGVSQEFVDSLDRVNRKTLDKDDDCAICKVPYLEDEYCLVVELPCNGAHRFDLECVGPWLRSKGTCPMCRQDLAKKKEVPIVEDSEEEDGDMMYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7YMI8</accession>
    <name>C7YMI8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Expressed protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">NECHADRAFT_99684</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052671.1">
        <property type="nucleotide sequence ID" value="XM_003052625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YMI8"/>
    <dbReference type="STRING" id="660122.C7YMI8"/>
    <dbReference type="GeneID" id="9671203"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_99684"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_99684"/>
    <dbReference type="eggNOG" id="ENOG502S2Z9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101422_0_0_1"/>
    <dbReference type="InParanoid" id="C7YMI8"/>
    <dbReference type="OMA" id="ACQCASD"/>
    <dbReference type="OrthoDB" id="3559948at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF2">
        <property type="entry name" value="GPI ANCHORED CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G10580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013356759" evidence="17">
        <location>
            <begin position="16"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="18">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="91"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="145"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEU46958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="214" mass="21312" checksum="57A7FEE6EF6FDDD5" modified="2009-10-13" version="1">MKATLFLAAAGLVAAQDFTGQPKCALKCLEEYVPKAGCDLEDTACQCDPAFQEKLTPQISPCLMKECEAADLPKALAAAQAACEAFSSAAGKSTGTVTPTATVSATEVETETETASDEEDNTETVTASVDTSITGSVTLPAIFSTTTDVPVTPGPNNRTTTKATGTGASGSDGTGSGSETSETGAAASETGNAAAMTGPAMGGFLAILAAFFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7YMU6</accession>
    <name>C7YMU6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein EFR3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_10759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053220.1">
        <property type="nucleotide sequence ID" value="XM_003053174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YMU6"/>
    <dbReference type="STRING" id="660122.C7YMU6"/>
    <dbReference type="GeneID" id="9664211"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_10759"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_10759"/>
    <dbReference type="eggNOG" id="KOG1877">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003271_0_0_1"/>
    <dbReference type="InParanoid" id="C7YMU6"/>
    <dbReference type="OMA" id="ATHVYYT"/>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039786">
        <property type="entry name" value="EFR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049150">
        <property type="entry name" value="EFR3_HEAT-like_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766:SF1">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21072">
        <property type="entry name" value="EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="876"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="953"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="907"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="981"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="997"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1008"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU47507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1008" mass="110898" checksum="B0F228C52A99E9D6" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNF9</accession>
    <name>C7YNF9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 15">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">NECHADRAFT_36117</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 15"/>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053332.1">
        <property type="nucleotide sequence ID" value="XM_003053286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNF9"/>
    <dbReference type="FunCoup" id="C7YNF9">
        <property type="interactions" value="67"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YNF9"/>
    <dbReference type="GeneID" id="9671359"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_36117"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_36117"/>
    <dbReference type="eggNOG" id="KOG3359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008438_2_2_1"/>
    <dbReference type="InParanoid" id="C7YNF9"/>
    <dbReference type="OMA" id="KNVTPRL"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031502">
        <property type="term" value="C:dolichyl-phosphate-mannose-protein mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23283">
        <property type="entry name" value="beta-trefoil_MIR_PMT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000034">
        <property type="entry name" value="Dolichyl-phosphate-mannose-protein mannosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF50">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="616"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="658"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="687"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="720"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="340"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="417"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="486"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="868"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="911"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="921"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEU47619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="950" mass="106706" checksum="857A5E60824157F3" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNP2</accession>
    <name>C7YNP2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inhibitor of growth protein N-terminal histone-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_79374</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052323.1">
        <property type="nucleotide sequence ID" value="XM_003052277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNP2"/>
    <dbReference type="STRING" id="660122.C7YNP2"/>
    <dbReference type="GeneID" id="9670845"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79374"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79374"/>
    <dbReference type="eggNOG" id="KOG1973">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009357_0_0_1"/>
    <dbReference type="InParanoid" id="C7YNP2"/>
    <dbReference type="OMA" id="EVMIHRE"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <position position="820"/>
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            <position position="830"/>
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            <position position="834"/>
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        <location>
            <position position="873"/>
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    </feature>
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        <source>
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        <source>
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        <source>
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        </source>
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    <sequence length="920" mass="99423" checksum="250A4C81F15905AD" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNQ5</accession>
    <name>C7YNQ5_FUSV7</name>
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        <recommendedName>
            <fullName evidence="15">pH-response transcription factor pacC/RIM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">NECHADRAFT_60425</name>
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    <organism evidence="19 20">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="20">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        <text evidence="14">Belongs to the pacC/RIM101 family.</text>
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        <property type="project" value="UniProtKB-KW"/>
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    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 16" id="KW-0863">Zinc-finger</keyword>
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            <begin position="60"/>
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        <source>
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        <source>
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        <source>
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        <source>
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    </evidence>
    <sequence length="604" mass="65403" checksum="14C963BD4D46BB37" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPN1</accession>
    <name>C7YPN1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_99958</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052036.1">
        <property type="nucleotide sequence ID" value="XM_003051990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YPN1"/>
    <dbReference type="STRING" id="660122.C7YPN1"/>
    <dbReference type="GeneID" id="9668744"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_99958"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_99958"/>
    <dbReference type="eggNOG" id="ENOG502S7ZI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056562_0_0_1"/>
    <dbReference type="InParanoid" id="C7YPN1"/>
    <dbReference type="OMA" id="EFDKFTD"/>
    <dbReference type="OrthoDB" id="1939598at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14705">
        <property type="entry name" value="bZIP_Zip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000075">
        <property type="entry name" value="BZIP transcription factor (MetR)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF14">
        <property type="entry name" value="CRYPTOCEPHAL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="182"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="119"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU46323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="284" mass="31843" checksum="EB4FBD5F4658D6D3" modified="2009-10-13" version="1">MSNYNGRRGPNVSQYLRDLNAINRQESSNDEPFNMEEDLALFTNTQFFDFETGQNTDYQAHPVKADMEAPPSTSPSDGMTPAPSVVGDLSNFDFIQGEFSFPEFTSAYPSTPLNGFADGAQNFQAMQPNPSAAYQPVPQQQQQQQQPAHYGQQPVPQSAEKRKSESGPGAGRSMNFEEASRQAAEEDKRRRNTAASARFRIKKKQREQALEKSAKEMSEKVTSLESKVQQLEMENKWLKNLLVEKNEGNDEIVTLWKEFAASKTGGDKNKPESKSDSPVKEETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQ09</accession>
    <name>C7YQ09_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_100017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052099.1">
        <property type="nucleotide sequence ID" value="XM_003052053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQ09"/>
    <dbReference type="GeneID" id="9673402"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100017"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100017"/>
    <dbReference type="eggNOG" id="ENOG502RPZ4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1240231_0_0_1"/>
    <dbReference type="InParanoid" id="C7YQ09"/>
    <dbReference type="OMA" id="RGMQGYD"/>
    <dbReference type="OrthoDB" id="4809847at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU46386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="227" mass="25046" checksum="C5C24B54E02B68E1" modified="2009-10-13" version="1">MHTSKLNTQPNKAMFIDNIASLSDPLSSMSSIFSLVSLLTMAYQVRTPQPSVQQRLLTLLNTMSPALTTGTQTTPDSPRGYSREEILNSFVHFLSPVLNGMAGMLELLSAVDAFSRPEDFRQFWSLERSNLIRDFIESGGPLRGMEGYDVPFLEAFVKDSSCRIALGKNQGMLLLVPGDAEVGDDVWWDEDEQRLTVSRKGEEDLNAAEAYLDDGSRMAVLAISSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQT9</accession>
    <name>C7YQT9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_92827</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052244.1">
        <property type="nucleotide sequence ID" value="XM_003052198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQT9"/>
    <dbReference type="GeneID" id="9673697"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_92827"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_92827"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_6_1"/>
    <dbReference type="InParanoid" id="C7YQT9"/>
    <dbReference type="OMA" id="PEIHWAV"/>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000266">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="308"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="443"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="77"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU46531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="555" mass="60026" checksum="DBBF6F21388806B4" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7YR14</accession>
    <name>C7YR14_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNA polymerase II-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PAFA2101</name>
        <name evidence="5" type="ORF">NECHADRAFT_106056</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052280.1">
        <property type="nucleotide sequence ID" value="XM_003052234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YR14"/>
    <dbReference type="FunCoup" id="C7YR14">
        <property type="interactions" value="313"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YR14"/>
    <dbReference type="GeneID" id="9672818"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_106056"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_106056"/>
    <dbReference type="eggNOG" id="KOG2478">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021991_1_1_1"/>
    <dbReference type="InParanoid" id="C7YR14"/>
    <dbReference type="OMA" id="GAYYYPI"/>
    <dbReference type="OrthoDB" id="10260285at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007133">
        <property type="entry name" value="RNA_pol_II-assoc_Paf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188:SF12">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03985">
        <property type="entry name" value="Paf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="417"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="435"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU46567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="53123" checksum="9AD7332212641EB6" modified="2009-10-13" version="1">MSSSAPRSGERVIHQDFIARIRFSNALPPPPHPPKLLDIPNTGLASGQYTTPGFASRLAREQPLNIEADAELGMPLDLVGMPGVFDGDERSIQAPAHPPTLHPHDRPLLRPIAALGKLKVAEANVSFLRRTEYISSTVTKRHDGPLPRALLTKANKSRRFVEPAANSPQAIKRKIDKGFDIAEHDLKDPKRVKHPSKRNLTVVDCSPLIPDLDAFPDSGAYVTLKFHQNPVASESTYDKRLLSGLFRPIDRTPQEEEAYELALAAHDQDPVNNPKPQNLMNYDYYLAQSTSAGDRFRRKFDVENPEHNEEELYTHESDAGGCFQYNRLRAYETSQETELDHSTKFEEEIILAYNEDTFYPNQKAVYYYPVMQKSVIRPQRTKNIARKIGIAEEEQIVDQLDITVEDPTEVMKEAMKQYRENPLGWGQGEEEEEEEHGHHDAEGEEDAHHSPAGHRSRSASEDRDAEGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRG4</accession>
    <name>C7YRG4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Semialdehyde dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_41166</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051167.1">
        <property type="nucleotide sequence ID" value="XM_003051121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YRG4"/>
    <dbReference type="STRING" id="660122.C7YRG4"/>
    <dbReference type="GeneID" id="9667862"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_41166"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_41166"/>
    <dbReference type="eggNOG" id="KOG4354">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006384_3_0_1"/>
    <dbReference type="InParanoid" id="C7YRG4"/>
    <dbReference type="OMA" id="PHLTPMI"/>
    <dbReference type="OrthoDB" id="438291at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd23936">
        <property type="entry name" value="AGPR_C_ARG5_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd24149">
        <property type="entry name" value="AGPR_N_ARG5_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000019">
        <property type="entry name" value="Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050085">
        <property type="entry name" value="AGPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023013">
        <property type="entry name" value="AGPR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058924">
        <property type="entry name" value="AGPR_dimerisation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32338:SF10">
        <property type="entry name" value="N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATE REDUCTASE, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32338">
        <property type="entry name" value="N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATE REDUCTASE, CHLOROPLASTIC-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22698">
        <property type="entry name" value="Semialdhyde_dhC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01224">
        <property type="entry name" value="ARGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdehyde dehydrogenase NAD-binding" evidence="7">
        <location>
            <begin position="63"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU45454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="374" mass="40583" checksum="4D64BF7B9F216038" modified="2009-10-13" version="1">MFSATSGAVRISARRIAPRATSGNTHIAQDRFLSSTGRLSYAINTNPNPPLGKKNASNDVPSRIGLIGARGYTGQALIDLLNKHPNMDLRHVSSRELCGQELEGYSKRKIIYENLSPEEVAQLDQDGKVDCWVMALPNGVCQPFVEALGQSSSLIVDLSADYRFDGTWAYGLPELVQRSKIAQATRISNPGCYATGSQLALSPILEHLGGMPTVFGASGYSGAGTKPSPKNDVKLLHDNLIPYSLTGHVHEREISHHLGAPTSFIPHVASWFRGIHLTVNIPLNKTLTSRDIRQMYQDRYAGEKLVKVVGEAPLVKSIQNKHGVEIGGFAVDKTGKRVVVCATIDNLNKGAATQCLQNMNLALGYDEYQGIPIE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-03-04" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7YS90</accession>
    <name>NIT_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Arylacetonitrilase</fullName>
            <ecNumber evidence="2 3">3.5.5.1</ecNumber>
            <ecNumber evidence="2 3">3.5.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">NitNh</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">NECHADRAFT_80653</name>
    </gene>
    <organism>
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2013" name="Biocatal. Biotransformation" volume="31" first="49" last="56">
            <title>Heterologous expression, purification and characterization of arylacetonitrilases from Nectria haematococca and Arthroderma benhamiae.</title>
            <authorList>
                <person name="Vesela A.B."/>
                <person name="Petrickova A."/>
                <person name="Weyrauch P."/>
                <person name="Martinkova L."/>
            </authorList>
            <dbReference type="DOI" id="10.3109/10242422.2012.758117"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Mol. Biotechnol." volume="54" first="996" last="1003">
            <title>A comparative study of nitrilases identified by genome mining.</title>
            <authorList>
                <person name="Kaplan O."/>
                <person name="Vesela A.B."/>
                <person name="Petrickova A."/>
                <person name="Pasquarelli F."/>
                <person name="Picmanova M."/>
                <person name="Rinagelova A."/>
                <person name="Bhalla T.C."/>
                <person name="Patek M."/>
                <person name="Martinkova L."/>
            </authorList>
            <dbReference type="PubMed" id="23475593"/>
            <dbReference type="DOI" id="10.1007/s12033-013-9656-6"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
    </reference>
    <comment type="function">
        <text evidence="2 3">Nitrilase that hydrolyzes preferentially phenylacetonitrile, (R,S)-mandelonitrile, and 3-indolylacetonitrile.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>a nitrile + 2 H2O = a carboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18379"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="EC" id="3.5.5.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>4-chlorophenylacetonitrile + 2 H2O = 4-chlorophenylacetate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20657"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16237"/>
            <dbReference type="ChEBI" id="CHEBI:17346"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.5.5"/>
        </reaction>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="3">8.3 mM for phenylacetonitrile</KM>
            <KM evidence="3">9.9 mM for (R,S)-mandelonitrile</KM>
            <Vmax evidence="3">111.1 umol/min/mg enzyme toward phenylacetonitrile</Vmax>
            <Vmax evidence="3">31.3 umol/min/mg enzyme toward (R,S)-mandelonitrile</Vmax>
        </kinetics>
        <phDependence>
            <text evidence="3">Optimum pH is 5.5-8.5.</text>
        </phDependence>
        <temperatureDependence>
            <text evidence="3">Optimum temperature is 40 degrees Celsius.</text>
        </temperatureDependence>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.5.1" evidence="2 3"/>
    <dbReference type="EC" id="3.5.5.5" evidence="2 3"/>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050920.1">
        <property type="nucleotide sequence ID" value="XM_003050874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YS90"/>
    <dbReference type="SMR" id="C7YS90"/>
    <dbReference type="STRING" id="660122.C7YS90"/>
    <dbReference type="EnsemblFungi" id="NechaT80653">
        <property type="protein sequence ID" value="NechaP80653"/>
        <property type="gene ID" value="NechaG80653"/>
    </dbReference>
    <dbReference type="GeneID" id="9666163"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_80653"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_80653"/>
    <dbReference type="eggNOG" id="KOG0805">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_6_0_1"/>
    <dbReference type="InParanoid" id="C7YS90"/>
    <dbReference type="OMA" id="GYPCWIW"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047428">
        <property type="term" value="F:arylacetonitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000011">
        <property type="entry name" value="Cyanide hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF14">
        <property type="entry name" value="ARYLACETONITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00920">
        <property type="entry name" value="NITRIL_CHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000432172" description="Arylacetonitrilase">
        <location>
            <begin position="1"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="23475593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source ref="2"/>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="23475593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source ref="2"/>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="339" mass="36773" checksum="5CE9EA7B4E06CFFD" modified="2009-10-13" version="1">MACPIRVAVTQAEPVYLDLAASVKKACGLIAEAAQNGAKLVAFSECWLPGYPAWIWARPVDFELQTRYIYNSLPIESEAMELVKATAKEHSIAVALGFSEQSPSHSIYISQAIISPQGEVVMHRRKIKPTHMERTLFGDGSGADLNNVVEVDFGAEHGKIKVGCFACWEHTQPLLKYHSISQGEAIHISMWPPIDPSAGVDHPGLWSMTADGCQNLSQTYAIESTAYVLHSTSVCTQKGIETLKTQDGLSCRQPGGGHSCVIGPDGRRLTAPLGDGSPDAEGIVYADLDLTKVVATRGFLDIVGHYSRPDLLWLGVDREQKENIIAKQHKAAEQEAVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSN8</accession>
    <name>C7YSN8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_41289</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051385.1">
        <property type="nucleotide sequence ID" value="XM_003051339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSN8"/>
    <dbReference type="STRING" id="660122.C7YSN8"/>
    <dbReference type="GeneID" id="9666310"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_41289"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_41289"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000134_18_9_1"/>
    <dbReference type="InParanoid" id="C7YSN8"/>
    <dbReference type="OMA" id="HTRNNCI"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF194">
        <property type="entry name" value="INVERSIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="61"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU45672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="114" mass="12818" checksum="CBA4C7B58CE25582" modified="2009-10-13" version="1" fragment="single">MLWAVRQLLDYTPVSPDDTSLLSATDEDGRQPLHFACLRGHRDVADLLLQRGADIDARGNDRATPIDDACFKGHKDVVELLISRGANTQMVDKNLWSPLRTAVRYENLDIVEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7YT34</accession>
    <name>C7YT34_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dihydrodipicolinate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_80934</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051466.1">
        <property type="nucleotide sequence ID" value="XM_003051420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YT34"/>
    <dbReference type="GeneID" id="9666451"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_80934"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_80934"/>
    <dbReference type="eggNOG" id="ENOG502RTV6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_5_0_1"/>
    <dbReference type="InParanoid" id="C7YT34"/>
    <dbReference type="OMA" id="YWNAISA"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008747">
        <property type="term" value="F:N-acetylneuraminate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42849">
        <property type="entry name" value="N-ACETYLNEURAMINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42849:SF1">
        <property type="entry name" value="N-ACETYLNEURAMINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0704">Schiff base</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002987551" description="Dihydrodipicolinate synthase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="4">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU45753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="31543" checksum="7627DF3FBA5DF5F9" modified="2009-10-13" version="1">MAPQKELTGILVALITPFTADGAVDLPALDVHIQRQIDAGVHGLVPGGSTGEFTALTVDERKAVLEQCIKSAAGRVPVIAGIGDLTTAGVVDLAKHAAKVGADSLMVVPPFYDAPSLAQLRDMFDEIHKASGLPIMYYNIPAASGVSLTPLEIAGLSEVGVKYLKDTSGNAPALTDLLFHHHGSITALNGWDTLTFYGLAAGAKGSVWGTTNVLPELSVQLWNALAVENDLKKGREIWSKIFPICKFLEAHQYGPAVKTGMELRGWKTGGLRKPFHLLPDDERAELAGLLKDAGVPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7YTC3</accession>
    <name>C7YTC3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6536 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_80253</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050724.1">
        <property type="nucleotide sequence ID" value="XM_003050678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YTC3"/>
    <dbReference type="GeneID" id="9665742"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_80253"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_80253"/>
    <dbReference type="eggNOG" id="ENOG502RYAY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010112_3_0_1"/>
    <dbReference type="InParanoid" id="C7YTC3"/>
    <dbReference type="OMA" id="NFMRGET"/>
    <dbReference type="OrthoDB" id="5429634at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046623">
        <property type="entry name" value="DUF6536"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395:SF1">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20163">
        <property type="entry name" value="DUF6536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="522"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="573"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="640"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="674"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6536" evidence="3">
        <location>
            <begin position="193"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU45011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="779" mass="83558" checksum="2E15046288B0508D" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7YTZ1</accession>
    <name>C7YTZ1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_96188</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050421.1">
        <property type="nucleotide sequence ID" value="XM_003050375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YTZ1"/>
    <dbReference type="GeneID" id="9674824"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_96188"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_96188"/>
    <dbReference type="eggNOG" id="KOG1237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004790_4_1_1"/>
    <dbReference type="InParanoid" id="C7YTZ1"/>
    <dbReference type="OMA" id="SNLTQMC"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="539"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="566"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU44708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="621" mass="68780" checksum="D04D973AB98F4848" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7YU29</accession>
    <name>C7YU29_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_101624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050054.1">
        <property type="nucleotide sequence ID" value="XM_003050008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YU29"/>
    <dbReference type="STRING" id="660122.C7YU29"/>
    <dbReference type="GeneID" id="9674839"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101624"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101624"/>
    <dbReference type="eggNOG" id="ENOG502R2IV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054998_0_0_1"/>
    <dbReference type="InParanoid" id="C7YU29"/>
    <dbReference type="OMA" id="TYHEFAQ"/>
    <dbReference type="OrthoDB" id="4838114at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU44341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="398" mass="43449" checksum="83BF35DC7D33AF0A" modified="2009-10-13" version="1">MSRVTQHSPQRELDAPKLDTSFAQRGDQHSQSRAQIEALSVEPPIYSPSADADESSPESTPTTMIPTQRSVSAGGAPALPAKSSLRASRVLDGLLKLTPGEQPPFTTQSAPHDVYLSSEEDASSSADDFSDFESDSGSDESRTSSKRRGSHEDTARVVSVVYSGKPSMIHLPRRSVSPSSSASEASSSRPSSRLSSLSRPPSRLRRTSTLPVLDRRMSLCTSSSGTILHPPRTSSMGSSRLEKQRPEFLSIDPFAIKSEPETKDDQNDRPKTPKTPTGMFKRTLSLVKKRSRPSLNTHHATLSRDNLSLFTPTFHMEQVREEPTATDSDSQQSAPTPILNKAPTYHDIMKTAQRRTSTAPMSPMSPMSEPASPMTPNSTRSRLRRGLEAAARRRSVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7YUC3</accession>
    <name>C7YUC3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">trimethyllysine dioxygenase</fullName>
            <ecNumber evidence="5">1.14.11.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Epsilon-trimethyllysine 2-oxoglutarate dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">TML hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">TML-alpha-ketoglutarate dioxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">NECHADRAFT_49296</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6),N(6),N(6)-trimethyl-L-lysine + 2-oxoglutarate + O2 = (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:14181"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:58100"/>
            <dbReference type="ChEBI" id="CHEBI:141499"/>
            <dbReference type="EC" id="1.14.11.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; carnitine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.8" evidence="5"/>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050493.1">
        <property type="nucleotide sequence ID" value="XM_003050447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YUC3"/>
    <dbReference type="STRING" id="660122.C7YUC3"/>
    <dbReference type="GeneID" id="9665466"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_49296"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_49296"/>
    <dbReference type="eggNOG" id="KOG3889">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021859_2_1_1"/>
    <dbReference type="InParanoid" id="C7YUC3"/>
    <dbReference type="OMA" id="EKVCIQP"/>
    <dbReference type="OrthoDB" id="408743at2759"/>
    <dbReference type="UniPathway" id="UPA00118"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050353">
        <property type="term" value="F:trimethyllysine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000001">
        <property type="entry name" value="Trimethyllysine dioxygenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012776">
        <property type="entry name" value="Trimethyllysine_dOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02410">
        <property type="entry name" value="carnitine_TMLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF51">
        <property type="entry name" value="TRIMETHYLLYSINE DIOXYGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0124">Carnitine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="17">
        <location>
            <begin position="9"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="16">
        <location>
            <begin position="92"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEU44780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="385" mass="44240" checksum="B55DAD514F225BDD" modified="2009-10-13" version="1">MFRRSADGWARDNCQCTQCVNQDTRQRNFDTFQLPEDVHPVNFSETEKHLEVQWSDSHKSQHPWSWLDSWFEGGYAEQTRVFWNSSIEDAPPEVAFDAVMSKSDEKGMADLTRNIWVHGFSFVVDTPPTPDATESLLEKVGPIRTTHYGGFYDFIPDLALADTAYTNLALPAHTDTTYFSEPAGLQAFHLLSHHAPPNAKPSDDALGGQSLLVDGFQVASTLKKESPEAYETLRTIQVPWHASGNKGIAIVPDRTYPVIEEDNGELTRVRWNNDDRGILDVFNAEKWYSAARKWNEIIRRRSSEYWFQLTPGRVVIFDNWRVMHGRSAFEGIRRICGAYTPRDDFMSRYRETNFPHESVIGRNLNMRSRKPTENKQEYEAITRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7YUV7</accession>
    <name>C7YUV7_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_85056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050189.1">
        <property type="nucleotide sequence ID" value="XM_003050143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YUV7"/>
    <dbReference type="GeneID" id="9665710"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85056"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85056"/>
    <dbReference type="eggNOG" id="ENOG502T44S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1489019_0_0_1"/>
    <dbReference type="InParanoid" id="C7YUV7"/>
    <dbReference type="OMA" id="VAWICTW"/>
    <dbReference type="OrthoDB" id="3750908at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU44476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="178" mass="19822" checksum="9C62432F2ACCE107" modified="2009-10-13" version="1">MADYNTNKTSAAGTGSWKDRNCPNMRTCWSFSWRAYDLRTGGDTKALLRRIAMCLTLVIRTFLSILGIVRNSYGSVLVSVIVGTILTILNFFFIGWCLAKVGEATGQRRVFGKLVGRVHFDIFLYFCAVIHIILLLSAFISWRGLGGAGLNGTWLAMWLLIFAVAWITTWAPEGESNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVA3</accession>
    <name>C7YVA3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_48581</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050662.1">
        <property type="nucleotide sequence ID" value="XM_003050616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVA3"/>
    <dbReference type="GeneID" id="9674692"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_48581"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_48581"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_16_5_1"/>
    <dbReference type="InParanoid" id="C7YVA3"/>
    <dbReference type="OMA" id="YCKMPAA"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="16"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU44949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="355" mass="37781" checksum="DB93FEE686E2043E" modified="2009-10-13" version="1">MSLPTTFKAATVAGKGENHITSERSLSPLKSGEVAIKITATAINPVDWKIRDYGVFIQEWPTVLGSDAAGEVVALGPDTSRVSVGDRVFFQGIIGNIESTTFQQYCKMPEALLAKTPSNISDEQAAGIQLTTIAAVTAFYDKTGRGLPAPWDEGGDSVGKGKAIVILGGSSSVGQYAVQLARLSGFERIVTNASSAHHEYLKTLGAHAVLDRTNTSLEDYVSTIGDYPLEFVFDTIGARVTQKLGVKIIQSLKVEGSRVATVSQADSEAKELGETKEPKVVVQGVVGFGSAPHLRYLSEPLAEHLGGEEGWISKGLFTPNRVTVVPGGLDNIEEALAKNKRGVSGEKVVIRPWDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVJ3</accession>
    <name>C7YVJ3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_30210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU43804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049517.1">
        <property type="nucleotide sequence ID" value="XM_003049471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVJ3"/>
    <dbReference type="GeneID" id="9677294"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_30210"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_30210"/>
    <dbReference type="eggNOG" id="ENOG502RZSK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008976_0_0_1"/>
    <dbReference type="InParanoid" id="C7YVJ3"/>
    <dbReference type="OMA" id="PVAQMFK"/>
    <dbReference type="OrthoDB" id="5238236at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046539">
        <property type="entry name" value="DUF6604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795:SF1">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20253">
        <property type="entry name" value="DUF6604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6604" evidence="2">
        <location>
            <begin position="5"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU43804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="810" mass="90527" checksum="F335C7C99BC4380B" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVV3</accession>
    <name>C7YVV3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_30373</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049779.1">
        <property type="nucleotide sequence ID" value="XM_003049733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVV3"/>
    <dbReference type="STRING" id="660122.C7YVV3"/>
    <dbReference type="GeneID" id="9677142"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_30373"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_30373"/>
    <dbReference type="eggNOG" id="KOG0805">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_6_1_1"/>
    <dbReference type="InParanoid" id="C7YVV3"/>
    <dbReference type="OMA" id="GYPKMST"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF12">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU44066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="401" mass="43164" checksum="C790A3F5CFE512B7" modified="2009-10-13" version="1">MATASTIRLGTASPGTQESTPATIALIDTIARRAAASNIDILLLPEAFIGGYPRGSSFGCEIGNRSQEGRDEFVRYFEQAIDLGDTVGPGGGGAGVKWAKRQLGGDDDQVRGDGSREELERIARDTGVFIVVGCIEKAGGSLYCSVVYICPKEGMLGKRRKVLPTGSERLIWAQASPSTLQAVTTIIRGVRINLAAAICWENYMPLLRQSLYAQNINLYLAPTADNRDAWLGLMRTVGVEGRCFVVSSNMCIPKTGGETNGSAPPTTRGRRNSTLTEDGFEIALPKSPTRRRRKSVFDEDGNEIVLGCDEDGEAPAPPSTSSRPQTHKTEFLSRGGSSIVSPFGDVIAGPQWEDPDGLVYADVDFRDCIRGRLDLDAAGSYSRNDAFKFSVEGLNLDPLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7YW61</accession>
    <name>C7YW61_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Cutinase</fullName>
            <ecNumber evidence="3 12">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_30450</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cutinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="3 12"/>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049830.1">
        <property type="nucleotide sequence ID" value="XM_003049784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YW61"/>
    <dbReference type="ESTHER" id="nech7-c7yw61">
        <property type="family name" value="Cutinase"/>
    </dbReference>
    <dbReference type="GeneID" id="9677405"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_30450"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_30450"/>
    <dbReference type="eggNOG" id="ENOG502S3AW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040058_2_2_1"/>
    <dbReference type="InParanoid" id="C7YW61"/>
    <dbReference type="OMA" id="NDARDHI"/>
    <dbReference type="OrthoDB" id="2975078at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043580">
        <property type="entry name" value="CUTINASE_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043579">
        <property type="entry name" value="CUTINASE_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF2">
        <property type="entry name" value="CUTINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00129">
        <property type="entry name" value="CUTINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00155">
        <property type="entry name" value="CUTINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00931">
        <property type="entry name" value="CUTINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 12" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005125809" description="Cutinase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="40"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="173"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU44117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="208" mass="21267" checksum="35944EA432648EE8" modified="2009-10-13" version="1">MPSFTKTILLALAPFAAASPLAARQSGFSGSTQNGLEGACKDVTVIFARGTSEMGNVGSVAGPPFFQALAKEIGSDKLAVQGVEYPASIAGIMDLGSDGGKKMVAVVEQAYKKCPNTKVVLSGYSQGAMLVHNAAKSLPAATTSKIAAVVTFGDPFKSQSFQGIDEGRCKVFCRSGDSVCSGSFVITAAHLQYGQDAQAAADFVAGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXL1</accession>
    <name>C7YXL1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_94934</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049076.1">
        <property type="nucleotide sequence ID" value="XM_003049030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXL1"/>
    <dbReference type="GeneID" id="9666374"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94934"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94934"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_11_0_1"/>
    <dbReference type="InParanoid" id="C7YXL1"/>
    <dbReference type="OMA" id="VMAINIC"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="56"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU43363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="538" mass="58470" checksum="E8E191FEE73A07B0" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXP6</accession>
    <name>C7YXP6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_82603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049092.1">
        <property type="nucleotide sequence ID" value="XM_003049046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXP6"/>
    <dbReference type="GeneID" id="9676984"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82603"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82603"/>
    <dbReference type="eggNOG" id="ENOG502SIYG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_371753_0_0_1"/>
    <dbReference type="InParanoid" id="C7YXP6"/>
    <dbReference type="OMA" id="THIMLCK"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF81">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="301"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU43379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="748" mass="83659" checksum="818AAF6EE81A5D4B" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7YY14</accession>
    <name>C7YY14_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_62422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049144.1">
        <property type="nucleotide sequence ID" value="XM_003049098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YY14"/>
    <dbReference type="GeneID" id="9677036"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_62422"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_62422"/>
    <dbReference type="eggNOG" id="ENOG502SJGS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_1_2_1"/>
    <dbReference type="InParanoid" id="C7YY14"/>
    <dbReference type="OMA" id="PCEAITH"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU43431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="37392" checksum="8C1219371D1C1D01" modified="2009-10-13" version="1">MQEIIEPDDHDSTYGDNEDTASSTASLSSSILDYRKENGRTYHKFHDGKYHFPNDDAENERLDLQHHIFYLTLDGKLGFAPPNKPDAKVGRVLDLGTGTGIWAMDFGDEHPEAEVIGIDLSPSQPQFVPPNVRFEIDDWDEEWTYSQPFDYIHSRMNNSSISDWEDYIRKSFENLKPGGYIELQEFTLPLSDDGTLAPEHALFQSMKHLGEAAAKSGRAFIDLNKLGGLLEKAGFEDVQEYKFKWPSNTWPRDPKYKELGIWNHENIVAGLQGFLMAALTRGLGWQAEEVNVLAAKAKQDMRNKSIHAYWPMIVVTARKPVPKETTAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7YY55</accession>
    <name>C7YY55_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extradiol ring-cleavage dioxygenase class III enzyme subunit B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_83573</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU42942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048655.1">
        <property type="nucleotide sequence ID" value="XM_003048609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YY55"/>
    <dbReference type="STRING" id="660122.C7YY55"/>
    <dbReference type="GeneID" id="9665769"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83573"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83573"/>
    <dbReference type="eggNOG" id="ENOG502S0K5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046582_4_0_1"/>
    <dbReference type="InParanoid" id="C7YY55"/>
    <dbReference type="OMA" id="FDPHFHM"/>
    <dbReference type="OrthoDB" id="7396853at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF1">
        <property type="entry name" value="AROMATIC RING-OPENING DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G00640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="6">
        <location>
            <begin position="8"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU42942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="292" mass="32689" checksum="EB3BE0555D30D44C" modified="2009-10-13" version="1">MAQLTPVHFFSHGSTMMLGEESEAADYWKKAGDQALANKIKGVRPSNKKQGAHWDALGDRIEVATNPQPGKSPVAYVHPSKYVDYKLNPDLETAERCISLLSKAGFDVSGNPTFEWIHDTYLILIRMFPNGCPPTTLISMNGRFDPHYHMKVGKALRCLRSEGYLIIGSGGAVHNLYRNIWGPMVKYTDNFGQETPPEPWALEFRQAVEDVIKNNTGPHLRRAMTRLMKHPLYRDAHATDDHFMAAVFVAGAVGDEEDEGVYGELKAETWELTNMCNSQFTFGSWPRTVATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7YY88</accession>
    <name>C7YY88_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_70932</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU42963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048676.1">
        <property type="nucleotide sequence ID" value="XM_003048630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YY88"/>
    <dbReference type="GeneID" id="9667801"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_70932"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_70932"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006909_5_3_1"/>
    <dbReference type="InParanoid" id="C7YY88"/>
    <dbReference type="OMA" id="GRYNAYF"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU42963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="53557" checksum="86B1EBEE63AFA16E" modified="2009-10-13" version="1">MAIPPVKRVAVIGAGPAGAIAVDALAQEKTFDLIRVFERREGPGGCWIDDKAQPPTVSNLSQLADRTADVPLTIPEKLPAYAPKSSQPRFEESSIYPYLETNVASVAMEFTQEPIPEIRSEWSVGIHGPDTPFRTWKVIRDYIAGLLQRNNYEDLVSYSTTVEHVEKVGEEWKVVLRKEGNEKDYWWTEWFDAVVVASGHYWVPYIPPIDGLDQFEKSRPGSVLHSKHFRGRDYFKGKRVVTVGASVSAADIAVDLVGTAKSPVHSITIGHTVNAYFGDGAFSHPKIKKHPSISKVTGRTVHLIDGTSILDVDHIIFGTGYSWTLPFLPSVPVRNNRVPGIYQHVVWNQDHTLLFVGAVGAGLTFKIFEWQAVYAARLLAGRASPPSVEEMQEWETERIKTHGDGPKFSVVYPDFEDYFDKVRELAGEGEPGVGRKLPPFRREWFRAFNEGSDLRKAMWERSNAKAEAEEVDESRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZH4</accession>
    <name>C7YZH4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_71324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048317.1">
        <property type="nucleotide sequence ID" value="XM_003048271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZH4"/>
    <dbReference type="GeneID" id="9667768"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_71324"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_71324"/>
    <dbReference type="eggNOG" id="ENOG502SAYW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_10_5_1"/>
    <dbReference type="InParanoid" id="C7YZH4"/>
    <dbReference type="OMA" id="CTHFLEE"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051604">
        <property type="entry name" value="Ergot_Alk_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162:SF1">
        <property type="entry name" value="PRESTALK A DIFFERENTIATION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="299" mass="32616" checksum="7B9EFF95AF84A131" modified="2009-10-13" version="1">MAPHITVIPASTKAGRETIRVLLNSESKPLVRGIYRDASKAPSEFVQNSNFKAVQGDVGAGTGLDFGTSDAVFYIPPPIYDGTDSGEFATRAGNNIKNALKASPSVKRLLLFSAIGAQNDHGIGILRLNHIAENILKDAVPEVIIIRPSYFQEDLASVLEEARADPPVITSIFSPADHKIPMVSLKDISEICANSLLAETAKPSPHYFKLFGPRSYSALDLKKAVEEVTGKTVELKLIERDQLSEFFAKQLPEPYVQELVDMTTAGLPGGVIDKDFVYDDDTVQGRVELVDTLRELYTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZI9</accession>
    <name>C7YZI9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NECHADRAFT_71329</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048327.1">
        <property type="nucleotide sequence ID" value="XM_003048281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZI9"/>
    <dbReference type="GeneID" id="9667404"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_71329"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_71329"/>
    <dbReference type="eggNOG" id="KOG1012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002125_2_0_1"/>
    <dbReference type="InParanoid" id="C7YZI9"/>
    <dbReference type="OMA" id="WDSDRNT"/>
    <dbReference type="OrthoDB" id="419768at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04041">
        <property type="entry name" value="C2A_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21676">
        <property type="entry name" value="SMP_Mug190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057349">
        <property type="entry name" value="C2_Mug190_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037767">
        <property type="entry name" value="C2A_Mug190-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348:SF3">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25331">
        <property type="entry name" value="C2_Mug190_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="373"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="14">
        <location>
            <begin position="245"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="470"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="659"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="34"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="697"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1073"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1082"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1127"/>
            <end position="1145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU42614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1209" mass="134779" checksum="85EFE063BE3CC2ED" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZN8</accession>
    <name>C7YZN8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_71364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048544.1">
        <property type="nucleotide sequence ID" value="XM_003048498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZN8"/>
    <dbReference type="STRING" id="660122.C7YZN8"/>
    <dbReference type="GeneID" id="9667621"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_71364"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_71364"/>
    <dbReference type="eggNOG" id="ENOG502RJG3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057150_0_0_1"/>
    <dbReference type="InParanoid" id="C7YZN8"/>
    <dbReference type="OMA" id="EMEHINN"/>
    <dbReference type="OrthoDB" id="4448936at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="263"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU42831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="394" mass="43507" checksum="343257636C2611A6" modified="2009-10-13" version="1">MDLAAIDEDPAAAIAAAEAAAAASVTDEQLIFSTPDRKMPISKSSSGATTPATGYFSYGNDYRSDYRHRYHDDHDSVPDQDLPGMRTPSLLSSPSVASSLGFSTGRLSPLRRELSGSRHSSHHDQEPDDASPTARRGARLSRSNRDTLARRLSQLAHELTSGNDDVDDVDVDLLTAQLDHLEASTRMKKTVSFSSNPSTPSPRPTPRRPLSVDMRSPGDSLFSSPGSSIFRTRFSDLSASIRRDPEPEPEPEPDPPPNMGMTVAQAKKVIQEVTQLNEEMSQLVANLKARQEESEHIQGLLIERAERAAQRIIFLQNRVSHLEQELRENDDELQHLRICLKAVEIQLPPHPDKELQRCLSSFKQDYQAMKRKRVNRTSIASLSSLGSPYPGSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0B5</accession>
    <name>C7Z0B5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_39816</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048063.1">
        <property type="nucleotide sequence ID" value="XM_003048017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0B5"/>
    <dbReference type="GeneID" id="9667235"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_39816"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_39816"/>
    <dbReference type="eggNOG" id="ENOG502QVGN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_10_1_1"/>
    <dbReference type="InParanoid" id="C7Z0B5"/>
    <dbReference type="OMA" id="QVYWDED"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002986697" description="FAD-binding PCMH-type domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="59"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU42350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="492" mass="53327" checksum="BE03409CCE14A935" modified="2009-10-13" version="1">MRSQLLRGLIGLAALVSPSLAVPTKREAVTSCLTNAKVPIDTKGSQTWTQDGTAYNLRLQFEPITIAVPTTVAQISAAVACGSKHGVSVSGKSGGHSYTSLGLGGEDGHLVIELDRLYSVKLAKDGTAKIQPGARLGHVATELYNQGKRALSHGTCPGVGLGGHALHGGYGMVSRKHGLTLDWIIGATVVLYDGKVVHCSKTERSDLFWAIRGAGASFGIVAELEFNTFPAPEKMTYFDIGLNWDQNTAAQGLWDVQEFGKTMPSEITMQVAIRKDSYSIDGAYVGDEAGLRKALQPLLSKLNVQVSASTVGWIDLVTHFAGTSDINPTSASYNAHDTFYATSLTTRELSLEQFRSFVNSVSTTGKSSSHSWWIQMDIQGGQYSAVAKPKPTDMAYVHRDALLLFQFYDSVPQGQKYPSDGFSLLTTLRQSISKSLREGTWGMYANYPDSQLKADRAAEMYWGSNLQKLQKIKAAYDPKNIFRNPQSVKPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0U2</accession>
    <name>C7Z0U2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginyltransferase</fullName>
            <ecNumber evidence="2">2.3.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_93290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the R-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.8" evidence="2"/>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048155.1">
        <property type="nucleotide sequence ID" value="XM_003048109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0U2"/>
    <dbReference type="FunCoup" id="C7Z0U2">
        <property type="interactions" value="611"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z0U2"/>
    <dbReference type="GeneID" id="9667327"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_93290"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_93290"/>
    <dbReference type="eggNOG" id="KOG1193">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020349_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z0U2"/>
    <dbReference type="OMA" id="KYQTAIH"/>
    <dbReference type="OrthoDB" id="74183at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004057">
        <property type="term" value="F:arginyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017137">
        <property type="entry name" value="Arg-tRNA-P_Trfase_1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030700">
        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007471">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367">
        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04376">
        <property type="entry name" value="ATE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037207">
        <property type="entry name" value="ATE1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="N-end aminoacyl transferase N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="7">
        <location>
            <begin position="167"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU42442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="340" mass="39370" checksum="F371547855046CA2" modified="2009-10-13" version="1">MYRPDQRRSCCPHYTIRLDSSQFKPSRDQRQTINRFNRYVMGETYTKEVARLHPKSRDQAKKRDNHFDLIERVHEAEDAQLLNPPEAAHKLVVTLETDDFTEEKFEVYENYQRVVHKEGPSKITAGGFKRFLCSSPLRRETMVDSNGKERRLGSYHHCYRLDGKLLGALYEIALSIEEGYGWWYPGFYIHSCPKMRYKIDYSPQFILDPNSLTWDPLDRKMLDLLDKKAFVSLSLEKQRDNKSDVESEGSKSGDDEDDWLFNVNMPGIPPLSSVADWDLDNIALKIRPDGPLYKTSNLVIWDKRGVEDYPGLKAGVAELVAAVGPDLIDRICLDFTPRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0Y0</accession>
    <name>C7Z0Y0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase III subunit RPC9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_80046</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC9 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047990.1">
        <property type="nucleotide sequence ID" value="XM_003047944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0Y0"/>
    <dbReference type="STRING" id="660122.C7Z0Y0"/>
    <dbReference type="GeneID" id="9667349"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_80046"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_80046"/>
    <dbReference type="eggNOG" id="KOG4168">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092529_3_1_1"/>
    <dbReference type="InParanoid" id="C7Z0Y0"/>
    <dbReference type="OMA" id="WGMHNLA"/>
    <dbReference type="OrthoDB" id="1746530at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038846">
        <property type="entry name" value="RPC9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561">
        <property type="entry name" value="CALCITONIN GENE-RELATED PEPTIDE-RECEPTOR COMPONENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU42277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="142" mass="16287" checksum="534BA6BCDF87F34B" modified="2009-10-13" version="1">MKILESQAAVLSNWEVYEHLTEQKERYKKTKHRGPQNYEDLVRYLLNYLRSNPNPLSEDPIPYTEGCITQLLERLRPFNLAKSEVIMIINLRPSTPPVLGSALEDMYERFTAEQQEEMVTIIAEVLGPFGQEAEADASMADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z137</accession>
    <name>C7Z137_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_80102</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048214.1">
        <property type="nucleotide sequence ID" value="XM_003048168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z137"/>
    <dbReference type="STRING" id="660122.C7Z137"/>
    <dbReference type="GeneID" id="9667386"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_80102"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_80102"/>
    <dbReference type="eggNOG" id="ENOG502S0GT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011409_3_0_1"/>
    <dbReference type="InParanoid" id="C7Z137"/>
    <dbReference type="OMA" id="SPHREGI"/>
    <dbReference type="OrthoDB" id="3172332at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU42501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="460" mass="52122" checksum="A00D953952DC7EC9" modified="2009-10-13" version="1">MSSQVTPPLAPSNRKPRSKVKSGCKTCKVRKVKCDEGRPACRRCTSTGRVCDGYGIWGGGNARGVQRQGGLFESKTKDARVPIYPVTPISRPIQPNLALSLSPQQKIYFDWFKCRTASKLPGTFTSSFWNTLVFQAGSSEPAVLNAILALSSVHKGDAIGVELFRHLYQHPCIILQPAFDPQRTPTGHIRSLSDAWRQMEPILNNIFHLTQQARQHPITAREHTSQQLIKAKLAQWLNMFEAFNKIQPCEGSSDLVKAYQVIRVNHTMATIMADTCLHSDESIYDAYIDQFLLLITQLTRLWVVSAETEDFSLNWDLMYMPRSIIDMGWIAPLYFTAVKCRVHRIRLQAIRLLPCSGHREGIWDSTIAACVARKVMEMEEGDFYQGLDLGDDFDVETLPRPQDLALPLLPESRRLNEVELELSGAPMDRMLLFCKQQQHGVKRRVLISQYSVLLHLWVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1Q9</accession>
    <name>C7Z1Q9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61</fullName>
            <ecNumber evidence="1">2.1.1.220</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">tRNA(m1A58)-methyltransferase subunit TRM61</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_50848</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.220" evidence="1"/>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU42042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047755.1">
        <property type="nucleotide sequence ID" value="XM_003047709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1Q9"/>
    <dbReference type="STRING" id="660122.C7Z1Q9"/>
    <dbReference type="GeneID" id="9671717"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_50848"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_50848"/>
    <dbReference type="eggNOG" id="ENOG502RWWI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029873_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z1Q9"/>
    <dbReference type="OMA" id="NERHATP"/>
    <dbReference type="OrthoDB" id="5585464at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF1">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="290"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU42042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="324" mass="35608" checksum="ED07BD657D8D94B8" modified="2009-10-13" version="1">MASYIINSARYATPIYPHDANIIVSLLDLNLPRPGEEEYDTDHTPPPFEIFEAGTGMGSLTLHLARALHAGNPAIPPSLRNALCSARYKRDEFGLDLSPEVSAEYDTYKNNRRAILHTLDRNPKHSKAAHSLIRQFRRALYFPTVDFHVGSIDEYLSSRLAQTNNEPFLSHAILDLPSAHDHAEPVIQALHSNGLLIIFTPSISQIADFQAWILRSGQPIRPERVIELPVSTTADGVRDTGGGKEWDVKTVIPKDQPDGAPVQVMRPRVGDRIAGGGFVAVMRRWPAGQVPSEAQSLGDEAVSELDELSGTDEVPESEKPSESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1U2</accession>
    <name>C7Z1U2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_85915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU42061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047774.1">
        <property type="nucleotide sequence ID" value="XM_003047728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1U2"/>
    <dbReference type="STRING" id="660122.C7Z1U2"/>
    <dbReference type="GeneID" id="9671559"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85915"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85915"/>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009958_3_0_1"/>
    <dbReference type="InParanoid" id="C7Z1U2"/>
    <dbReference type="OrthoDB" id="2394218at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42749">
        <property type="entry name" value="CELL SHAPE-DETERMINING PROTEIN MREB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42749:SF1">
        <property type="entry name" value="CELL SHAPE-DETERMINING PROTEIN MREB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU42061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="541" mass="59880" checksum="673B95919892E244" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z208</accession>
    <name>C7Z208_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_50742</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU41918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047631.1">
        <property type="nucleotide sequence ID" value="XM_003047585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z208"/>
    <dbReference type="GeneID" id="9671590"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_50742"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_50742"/>
    <dbReference type="eggNOG" id="ENOG502SH4E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019101_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z208"/>
    <dbReference type="OMA" id="GIFIMIC"/>
    <dbReference type="OrthoDB" id="4329349at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF152">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="21"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="324"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="350"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU41918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="365" mass="40354" checksum="829A3528E46A60D4" modified="2009-10-13" version="1" fragment="single">AMPVDKELWGEYAAGAFMIILRFFARWKVIGIENFGIEDAFMGVALVTYSAITALIHLITQYGSTIGQTPESVYLLTDEQVASFAIGQKLTFADWLIYLLYIWSLKSTLLVMFARLAKDLPREELILKIVIGYTAFAFVGAAISHICVCLPVHKSWQVVPYPGDACALRNLNYYLVSFFNASSDLAIIAVPVPIIFKARIPLWRRLLLASLLCSGIFVIIATILRSYYSLKSITLLPVASGWTSRETFVAAVAVSIPGIKPLFSRSRWFRFRSTADNAAYYNGSRGKKGTHELVTFGGSGQRGRTDVEEEGAADWTVSGKEIRGTRLSSDGSEDIILSSRDERGMPSIYVTKSYTPSSEQRGSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z2J8</accession>
    <name>C7Z2J8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_53987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047203.1">
        <property type="nucleotide sequence ID" value="XM_003047157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z2J8"/>
    <dbReference type="GeneID" id="9676380"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_53987"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_53987"/>
    <dbReference type="eggNOG" id="ENOG502SH6F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_34_22_1"/>
    <dbReference type="InParanoid" id="C7Z2J8"/>
    <dbReference type="OMA" id="ERSCENC"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU41490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="324" mass="35142" checksum="2C191C6DD70D2AC5" modified="2009-10-13" version="1">MSRRKFRPEDYTVGWVCALPIELAAAQEVLDEGHPDITHLNPNDTNLYTLGRIGTHNVVIACLPAGQIGTNTAAAVATRMKSTFTSIRFGLMVGIGGGVPSDKADIRLGDVVISQPERGNGGVVQYDLGKTMPRRYERTGSLNSPPEILLNALSKLNTNQILGMSNLAHHLSTLSRSPVFTPQSAGPDILFESTYEHLGGDTCEGCDRNRQVRRYSRDSQEIVVHYGTIASGNQVMRDGQSRDRVSQELGGVLCFEMEAAGLMNSFPCLVLRGICDYADSHKNKTWQAYASATAAACAKEILLIIPRAAVAETRRVPGTILSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z2T9</accession>
    <name>C7Z2T9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_87715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047251.1">
        <property type="nucleotide sequence ID" value="XM_003047205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z2T9"/>
    <dbReference type="GeneID" id="9676092"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87715"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87715"/>
    <dbReference type="eggNOG" id="ENOG502SMA9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_293565_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z2T9"/>
    <dbReference type="OMA" id="FWRNGSK"/>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="275"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU41538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1035" mass="117839" checksum="CA93A78279CD606A" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z436</accession>
    <name>C7Z436_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CPAF-like PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_83467</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047120.1">
        <property type="nucleotide sequence ID" value="XM_003047074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z436"/>
    <dbReference type="STRING" id="660122.C7Z436"/>
    <dbReference type="GeneID" id="9675301"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83467"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83467"/>
    <dbReference type="eggNOG" id="ENOG502S4FW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014251_1_1_1"/>
    <dbReference type="InParanoid" id="C7Z436"/>
    <dbReference type="OMA" id="CLQSMPF"/>
    <dbReference type="OrthoDB" id="27214at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056186">
        <property type="entry name" value="PDZ_CPAF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052766">
        <property type="entry name" value="S41A_metabolite_peptidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049">
        <property type="entry name" value="PEPTIDASE S41 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049:SF4">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23658">
        <property type="entry name" value="PDZ_CPAF_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002986774" description="CPAF-like PDZ domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="CPAF-like PDZ" evidence="3">
        <location>
            <begin position="145"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU41407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="734" mass="78970" checksum="D9D46CA5D8184EE5" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z5V4</accession>
    <name>C7Z5V4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_75882</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046301.1">
        <property type="nucleotide sequence ID" value="XM_003046255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z5V4"/>
    <dbReference type="GeneID" id="9678138"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75882"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75882"/>
    <dbReference type="eggNOG" id="ENOG502SE9E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026660_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z5V4"/>
    <dbReference type="OMA" id="NASCACL"/>
    <dbReference type="OrthoDB" id="4356994at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="56"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="92"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU40588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="381" mass="42041" checksum="4E948E5F532AC09F" modified="2009-10-13" version="1">MHSRTVSTRSSPASDASRARLSCEPCRARKIRCTGEHPVCSKCFSKNRECSYSIQKAAGRPRTRQQSALGRDGRSRRRRAIELVPSPESLLDLSQDTSEPASEPPSSVHETPGSQDNGSESLSGPHHAVPPFLADFESYMHAQPQECSGLMPSLPLGTLNHSECIQPCACLSILYLLLNRIGSDAELVVPNDLSFLRNTVETAMDVLDCVKCPLRFSSVLQNATILGILCVCIAESYVRFVRAIDAKAQAAVEKEESLLVSLSNFEGPPSYPDQSKLGANPAAILVEVSPDQWKSLMHNAVKAEICGVEGHREKCFMHFIERLEERQTDWHRRPLAPDCPPTYQSACTSVDEVPLCLTIIKAARKFLDQIEHILQERAALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6P4</accession>
    <name>C7Z6P4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_102416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046441.1">
        <property type="nucleotide sequence ID" value="XM_003046395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6P4"/>
    <dbReference type="STRING" id="660122.C7Z6P4"/>
    <dbReference type="GeneID" id="9668076"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102416"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102416"/>
    <dbReference type="eggNOG" id="ENOG502SBV5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152072_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z6P4"/>
    <dbReference type="OMA" id="DKFFTHE"/>
    <dbReference type="OrthoDB" id="2391627at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019182">
        <property type="entry name" value="Cytochrome_b-c1_su10_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254:SF1">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09796">
        <property type="entry name" value="QCR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU40728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="88" mass="9825" checksum="ECF121DC60E51849" modified="2009-10-13" version="1">MVSYTPIRMAEFKSAYGPKYQSQPNLAGFTVQSATRIGTRLAFYGAPAVVGVLLFANGIPRVQRDILQKVPFFGDFFRKEIHPADNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7E5</accession>
    <name>C7Z7E5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RecA family profile 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_5950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046000.1">
        <property type="nucleotide sequence ID" value="XM_003045954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7E5"/>
    <dbReference type="STRING" id="660122.C7Z7E5"/>
    <dbReference type="GeneID" id="9668358"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_5950"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_5950"/>
    <dbReference type="eggNOG" id="ENOG502SFQN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043547_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z7E5"/>
    <dbReference type="OMA" id="IACNALR"/>
    <dbReference type="OrthoDB" id="5957327at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000707">
        <property type="term" value="P:meiotic DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052093">
        <property type="entry name" value="HR_Repair_Mediator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3 RAD51C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="310"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU40287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="38849" checksum="AD1253193FD07872" modified="2009-10-13" version="1" fragment="single">MDYHAIHGHDRASFDTSGAHRLPTVSASQALDELGGDASNHVSTGLEDLDHALAGTVSVDSQDSTPKGGVHRGQVTEIWGPPGTGKTALGLKAVIKTIKDDQGDSDVEAHDVEGDAGRFLHYSCLTLPHFVALISRPTAKVIPANTSLVVISSLSALVNSALPKSHDGKAISKSAKGIPFTKRLQALQSIMNALHKLAATRNCAVVILSQCATKMHSERGATLTAAVNATVWEQGVSTRLVVFRDWVWQEGKLASVFLAGLQKVDGKASQETVENVVAFKVELDGVAQIPYEAIQSIELARHKRKLGETELEVPDSEDDEDYGWADEDEAAMPAPPPQWQGSEDILLGQEVGRSEGENSDGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8M5</accession>
    <name>C7Z8M5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_94325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045101.1">
        <property type="nucleotide sequence ID" value="XM_003045055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8M5"/>
    <dbReference type="STRING" id="660122.C7Z8M5"/>
    <dbReference type="GeneID" id="9673531"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94325"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94325"/>
    <dbReference type="eggNOG" id="ENOG502S00D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052989_0_1_1"/>
    <dbReference type="InParanoid" id="C7Z8M5"/>
    <dbReference type="OMA" id="NGGMFLP"/>
    <dbReference type="OrthoDB" id="9977941at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052998">
        <property type="entry name" value="Hetero-Diels-Alderase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060:SF1">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU39388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="30419" checksum="96DB5412FA066FDD" modified="2009-10-13" version="1">MASIKTLFQLSSQPTWFENICIRPNGTILATRLDVPEVWAIDPATSSGSSLFRIPLSKDVPSQALTGICALRPDVFAIGAGIYDMAGGTGAKAGSFSVWLADLTGQEPKVTKVTDIPEIAMINGMATWDENTALVTDCLKGKVYRLDVTSGTYNIALEDETMEIPAGAPFQVGINGLKVHRTTEQIHVYYTTTTRYSVYRMPVTQELKPAGPVETLASGVVPDDLIVAQDGTVYVCTNVTNTVARIPPGGGGVVTVAGEAKAMTLAGSTACVFGEGEKMARLSQPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8T1</accession>
    <name>C7Z8T1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD-dependent oxidoreductase 2 FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_61924</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044738.1">
        <property type="nucleotide sequence ID" value="XM_003044692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8T1"/>
    <dbReference type="STRING" id="660122.C7Z8T1"/>
    <dbReference type="GeneID" id="9673648"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_61924"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_61924"/>
    <dbReference type="eggNOG" id="KOG2404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022946_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z8T1"/>
    <dbReference type="OMA" id="PEDHWPR"/>
    <dbReference type="OrthoDB" id="3345469at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014614">
        <property type="entry name" value="KsdD_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009472">
        <property type="entry name" value="PRK12834.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43260">
        <property type="entry name" value="3-KETOSTEROID-DELTA-1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43260:SF1">
        <property type="entry name" value="KSDD-LIKE STEROID DEHYDROGENASE RV0785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036654">
        <property type="entry name" value="UCP036654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="3">
        <location>
            <begin position="10"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU39025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="580" mass="63523" checksum="12814ED60B89E53D" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z928</accession>
    <name>C7Z928_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_100823</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU38949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044662.1">
        <property type="nucleotide sequence ID" value="XM_003044616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z928"/>
    <dbReference type="STRING" id="660122.C7Z928"/>
    <dbReference type="GeneID" id="9673497"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100823"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100823"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z928"/>
    <dbReference type="OMA" id="LWNDSHQ"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU38949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="332" mass="36803" checksum="1B12073833484DE9" modified="2009-10-13" version="1">MSFGRTVTLNSGHKVPVIGYGTWQSAPGEVGAGVYEALKAGYRHLDLAKIYQNQREVGEGLKKALAEVPGLKREDIFITSKLWNNKHRPEEVAGALDDTLEELGLDYLDLYLIHWPVAFKNGTELFPRKEGDDSQVAIDRGVSLSQTWKAVTELPKSKVRSIGVSNFSIEHLETVIKDTGVVPAVNQVERHPRLPNPELVAYLKEKGIVLTAYSAFGNNSWGLPLLVNVPEVKAIAERLSAAQGKTVTPAQVVLAWSTLDGHLVIPKSVTASRIRENFQEVELDAEAIKELDKLGEKPQRFNIPTTYDPKWDIDVFGDEKEKDATFQVVLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z978</accession>
    <name>C7Z978_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ornithine cyclodeaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_43932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ornithine cyclodeaminase/mu-crystallin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044720.1">
        <property type="nucleotide sequence ID" value="XM_003044674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z978"/>
    <dbReference type="FunCoup" id="C7Z978">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z978"/>
    <dbReference type="GeneID" id="9673630"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_43932"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_43932"/>
    <dbReference type="eggNOG" id="KOG3007">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042088_0_1_1"/>
    <dbReference type="InParanoid" id="C7Z978"/>
    <dbReference type="OMA" id="VKIVNVH"/>
    <dbReference type="OrthoDB" id="41492at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="entry name" value="ornithine cyclodeaminase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812:SF19">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="40213" checksum="691861FA2358C80C" modified="2009-10-13" version="1">MAFTVLSDNNVNHILDNLSSSDVVDLANALERALIQYSCNNEQQYQPHRAVVSRDDQVSLFMPGTTDQLLGVKIVGITPAEKLKPSEPGLKSVLTLCDARGQAIGTLNAAALTAFRTALGSMLPYRFRKNTENIVVFGAGKQALWHIRLALLLKEKDIKSVTIVNRSAQRTQELIESLKSNKNSPWPSHIDLKAFDPQGDRDAALESLVVDADVLFFTTPSTQPLFPAKYLTSEKALSKTRFFAAIGSYRLDMQEIDPELLKLVVDPSSVFASSGYQGGSVAVDSRDGCLQEAGELVKAEIPTDKMLEIGQLLQTKNTEKPADLTKWLETGFVIYKSVGTGVMDLAIGQQLLRLAKERNVGLTAEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9G9</accession>
    <name>C7Z9G9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_94471</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045216.1">
        <property type="nucleotide sequence ID" value="XM_003045170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9G9"/>
    <dbReference type="FunCoup" id="C7Z9G9">
        <property type="interactions" value="252"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z9G9"/>
    <dbReference type="GeneID" id="9673377"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94471"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94471"/>
    <dbReference type="eggNOG" id="KOG0698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013173_9_1_1"/>
    <dbReference type="InParanoid" id="C7Z9G9"/>
    <dbReference type="OMA" id="METDNGY"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF837">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="142"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="276"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="493"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="507"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="538"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="557"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU39503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="570" mass="60370" checksum="5D8627B7BA7A0E3E" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9R1</accession>
    <name>C7Z9R1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_81841</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003045212.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="nhe:NECHADRAFT_81841"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_81841"/>
    <dbReference type="eggNOG" id="ENOG502SSWB">
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    <dbReference type="InParanoid" id="C7Z9R1"/>
    <dbReference type="OMA" id="TECYTIY"/>
    <dbReference type="OrthoDB" id="5100468at2759"/>
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        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988642" description="Mid2 domain-containing protein" evidence="7">
        <location>
            <begin position="25"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="190"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="287"/>
            <end position="357"/>
        </location>
    </feature>
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        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
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        <location>
            <begin position="288"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU39545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="39743" checksum="96194CDE593F50AC" modified="2009-10-13" version="1">MGSSMRWLAVAAVAACALFDKTNASDVPPQGPEPTAPARIRALRPLQGLFRREDGTVTETLDITVAPDTLCGLYTPSTTYSFTCSPGTSCMWENNKYNLAFCGIEDFKTACIGQADATDDDKCDDNCRRDPNIQFCTLDTRPFCFTIYMPNGIKKYPCHTAAGFSSMIFPEGAANYATSTMDVTIYEAATTKPSESTKESTAEESKDETESDAETTKPKAAKTVTVGPTASSDSGSEKDASEDDGNEKSGSSKTNIGAIVGGVVGGIAVIAAVVLAIFLIRRRDKNKAQPVQQVQPPPQQQMQYPVMAQQQQIPYQGWQQTPPPQGFHQTPSPQGFQQSPSTQTSVPGAVEAPDSNAVAVFELPDKVEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9X6</accession>
    <name>C7Z9X6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL23 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_62199</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044889.1">
        <property type="nucleotide sequence ID" value="XM_003044843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9X6"/>
    <dbReference type="FunCoup" id="C7Z9X6">
        <property type="interactions" value="780"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z9X6"/>
    <dbReference type="GeneID" id="9672247"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_62199"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_62199"/>
    <dbReference type="eggNOG" id="KOG1751">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037562_0_1_1"/>
    <dbReference type="InParanoid" id="C7Z9X6"/>
    <dbReference type="OMA" id="RLDHHKV"/>
    <dbReference type="OrthoDB" id="1267328at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000035">
        <property type="entry name" value="60S ribosomal protein L23a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_A">
        <property type="entry name" value="Ribosomal_uL23_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005633">
        <property type="entry name" value="Ribosomal_uL23_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011118">
        <property type="entry name" value="PRK14548.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L23A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03939">
        <property type="entry name" value="Ribosomal_L23eN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL23 N-terminal" evidence="7">
        <location>
            <begin position="16"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU39176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="154" mass="16969" checksum="8CBB758360915472" modified="2009-10-13" version="1">MAGKDTKGKKAPKGLSKANAAAKAALKGANSHKKTKVRYSTSFHRPKTLVVSRTPKYPRKSIPSQPRLDEHKIVIHPLNTESAMKKMEENNTLVFIVDVKANKAQIKLALKKLYDIDTVKINTLIRPDGSKKAYARLTPDVDALDIAANKLSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAJ2</accession>
    <name>C7ZAJ2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_82116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044997.1">
        <property type="nucleotide sequence ID" value="XM_003044951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAJ2"/>
    <dbReference type="GeneID" id="9672179"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82116"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82116"/>
    <dbReference type="eggNOG" id="ENOG502SUPB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080664_6_1_1"/>
    <dbReference type="InParanoid" id="C7ZAJ2"/>
    <dbReference type="OMA" id="QIATWKE"/>
    <dbReference type="OrthoDB" id="42919at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002986935" description="Stress-response A/B barrel domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Stress-response A/B barrel" evidence="2">
        <location>
            <begin position="8"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU39284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="109" mass="11606" checksum="CDBA76DD8DE745B2" modified="2009-10-13" version="1">MAIYHVVLTLAVLFKLKPNVPQQSIDEMRAAGKAMLGVVPGLRSFEFGSPLASTAHRAQGFDLGLIAVLDTEADVLAYGPHPAHQAVNKIREAVAAETLAYDLEVPDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAZ6</accession>
    <name>C7ZAZ6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_83075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044393.1">
        <property type="nucleotide sequence ID" value="XM_003044347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAZ6"/>
    <dbReference type="STRING" id="660122.C7ZAZ6"/>
    <dbReference type="GeneID" id="9670815"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83075"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83075"/>
    <dbReference type="eggNOG" id="ENOG502SN86">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_498828_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZAZ6"/>
    <dbReference type="OrthoDB" id="3789824at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="14"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU38680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="546" mass="61865" checksum="1B471E1C01B4F64A" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZB14</accession>
    <name>C7ZB14_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ester cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_45729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044427.1">
        <property type="nucleotide sequence ID" value="XM_003044381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZB14"/>
    <dbReference type="GeneID" id="9672730"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45729"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45729"/>
    <dbReference type="eggNOG" id="ENOG502SZDA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100997_5_2_1"/>
    <dbReference type="InParanoid" id="C7ZB14"/>
    <dbReference type="OMA" id="AYPDIQW"/>
    <dbReference type="OrthoDB" id="3657563at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436:SF1">
        <property type="entry name" value="ESTER CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="POLYKETIDE CYCLASE SNOAL-LIKE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07366">
        <property type="entry name" value="SnoaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU38714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="15315" checksum="A5FF88FAB23A4C58" modified="2009-10-13" version="1">MSTKKTFDRFVEFINSGDRTLGEQIIDESAEFHVPFDSKPLKGLDGYMQILGMMRGAFPDIQWTVEEIVCEGNKVVARFTTRGTHNGPFLGTPPSGKAIQMTAMNLYKIVNGKIVEEYGLPDMFGLMVQIGAVKIPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBH3</accession>
    <name>C7ZBH3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_83180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044450.1">
        <property type="nucleotide sequence ID" value="XM_003044404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBH3"/>
    <dbReference type="GeneID" id="9670764"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83180"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83180"/>
    <dbReference type="eggNOG" id="KOG0597">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036828_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZBH3"/>
    <dbReference type="OMA" id="HEMSEYD"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="4">
        <location>
            <begin position="129"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="246"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="557"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="557"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="578"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU38737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="606" mass="67418" checksum="99882DDD022580A8" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBP6</accession>
    <name>C7ZBP6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_88484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698915">
        <property type="protein sequence ID" value="EEU38552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044265.1">
        <property type="nucleotide sequence ID" value="XM_003044219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBP6"/>
    <dbReference type="GeneID" id="9670681"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88484"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88484"/>
    <dbReference type="HOGENOM" id="CLU_1461699_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZBP6"/>
    <dbReference type="OrthoDB" id="10364701at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU38552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="185" mass="20792" checksum="EA0EC094CCB4E76C" modified="2009-10-13" version="1">MTAFLETITPYYPIIPLELTRRLQRYHMASMGFATKGCDAVSASERCLIPFILFLGLRAANPPEARNTPLMDEDLNLSMRYAFIELAKLNDALSSLRAGLLAVVVNIYSMDVNEAMRSFDATSRLRSRYGQSQDMACSQAHRLIDWSFSQVEWGLSAFLDTPHWPTNTMLPDEGAFKAAVFTLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBQ4</accession>
    <name>C7ZBQ4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-dependent oxidoreductase 2 FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_55166</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GG698915">
        <property type="protein sequence ID" value="EEU38604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044317.1">
        <property type="nucleotide sequence ID" value="XM_003044271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBQ4"/>
    <dbReference type="STRING" id="660122.C7ZBQ4"/>
    <dbReference type="GeneID" id="9670687"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55166"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55166"/>
    <dbReference type="eggNOG" id="KOG2404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011398_4_2_1"/>
    <dbReference type="InParanoid" id="C7ZBQ4"/>
    <dbReference type="OMA" id="TCECRPF"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF10">
        <property type="entry name" value="3-OXOSTEROID 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="5">
        <location>
            <begin position="12"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU38604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="599" mass="65093" checksum="6173F880116A92DC" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBY1</accession>
    <name>C7ZBY1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_55318</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698916">
        <property type="protein sequence ID" value="EEU38493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044206.1">
        <property type="nucleotide sequence ID" value="XM_003044160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBY1"/>
    <dbReference type="STRING" id="660122.C7ZBY1"/>
    <dbReference type="GeneID" id="9670547"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55318"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55318"/>
    <dbReference type="eggNOG" id="KOG2451">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZBY1"/>
    <dbReference type="OMA" id="WQWVTVK"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07105">
        <property type="entry name" value="ALDH_SaliADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000012">
        <property type="entry name" value="NAD-dependent succinate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF6">
        <property type="entry name" value="CYTOPLASMIC ALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="30"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU38493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="488" mass="51851" checksum="2BAFCCAC534BC104" modified="2009-10-13" version="1">MASSDKANGSSTQTSDTVPFIINGKDVTSTSTFAVNNPSTGKELWNGSSASISEAIGAVEAAQAAFASWSQTKPSFRRGIMFRAADLFVSRKEELFSYQSQETGAGRQFMEININATAQILRDIGGRIEAAVEGSVPVTAEEGSHAIMVKEPYGVVLAIAPWNAPYVLGARSVAFALATGNTTVLKGSELSPRVFWAIGDIFRQAGLPDGCLNIIYHRPADAAAVTEALIAHPAIKKINFTGSTLVGSIIASLAGKHVKPLLLELGGKASAIVLQDADLKKAAASCAVGAFIHGGQVCMSTERILVHKSIAEDFSAALKKATQKLFGSEAPPFVLINSTAVQKNKRLIADAVSKGAVTLLGNAEATEDQPTKMRPIIVSNVFKDMEIYYTESFGPTVSLMTFETEEEALTVANDTDYGLSGAIFSEDLKAAMRVARKYESGAVHINSMTVHDEASLVHGGAKKSGYGRFNAAQGLGEFLRYKTITWRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCW1</accession>
    <name>C7ZCW1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_95927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698919">
        <property type="protein sequence ID" value="EEU37988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043701.1">
        <property type="nucleotide sequence ID" value="XM_003043655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCW1"/>
    <dbReference type="GeneID" id="9670189"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95927"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95927"/>
    <dbReference type="eggNOG" id="ENOG502RS70">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007043_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZCW1"/>
    <dbReference type="OMA" id="LVKRPWF"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="694"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1253" mass="139352" checksum="BA6C9F654844E987" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDD7</accession>
    <name>C7ZDD7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_8905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698919">
        <property type="protein sequence ID" value="EEU38082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043795.1">
        <property type="nucleotide sequence ID" value="XM_003043749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZDD7"/>
    <dbReference type="STRING" id="660122.C7ZDD7"/>
    <dbReference type="GeneID" id="9670157"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_8905"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_8905"/>
    <dbReference type="eggNOG" id="ENOG502S5NQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081911_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZDD7"/>
    <dbReference type="OMA" id="CFALGIM"/>
    <dbReference type="OrthoDB" id="4918558at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU38082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="22448" checksum="70EDE86EB7CDC2AC" modified="2009-10-13" version="1" fragment="single">LFVFFRVLQIVTLIPCMGMLAWFVDGFVKQNALTPDSILILFIVSVLALAWALFTLFSYHRSSTNAHFVAFVDILFFGAFIAAVYYLRYVRYTDCVSIRREEDWDVTLGDVRVIGPNYSLVNNKPCSMLKACWAFGIMNIIFFFTTAVVAFMHGGHMSAYDRSHSSRRSYHSSRHSHRSSRSRSGSRYSGSRPHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZF11</accession>
    <name>C7ZF11_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_101993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043128.1">
        <property type="nucleotide sequence ID" value="XM_003043082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZF11"/>
    <dbReference type="STRING" id="660122.C7ZF11"/>
    <dbReference type="GeneID" id="9665355"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101993"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101993"/>
    <dbReference type="eggNOG" id="ENOG502SN08">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020821_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZF11"/>
    <dbReference type="OMA" id="YGAWEMS"/>
    <dbReference type="OrthoDB" id="5357734at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37576">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37576:SF2">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="583" mass="64111" checksum="D3BA652A9A06AC2B" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFE3</accession>
    <name>C7ZFE3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amine oxidase</fullName>
            <ecNumber evidence="6">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_78478</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:26414"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:58855"/>
            <dbReference type="ChEBI" id="CHEBI:65296"/>
            <dbReference type="EC" id="1.4.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="6"/>
    <dbReference type="EMBL" id="GG698923">
        <property type="protein sequence ID" value="EEU37324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043037.1">
        <property type="nucleotide sequence ID" value="XM_003042991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFE3"/>
    <dbReference type="STRING" id="660122.C7ZFE3"/>
    <dbReference type="GeneID" id="9664990"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78478"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78478"/>
    <dbReference type="eggNOG" id="KOG0029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004498_9_0_1"/>
    <dbReference type="InParanoid" id="C7ZFE3"/>
    <dbReference type="OMA" id="THIAANI"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050703">
        <property type="entry name" value="Flavin_MAO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563:SF1">
        <property type="entry name" value="AMINE OXIDASE [FLAVIN-CONTAINING] B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="7">
        <location>
            <begin position="50"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="70"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU37324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="499" mass="55752" checksum="D45CDB3FBD1E08D7" modified="2009-10-13" version="1">MIPNTSEGYVWTAESGVVQGSLPCKGVIQPPTSIRNSRGVYDCIVIGAGFAGLTAARDLALAKRKVLLIEARDRIGGRTYSIEKDGYTYEMGGTWVSHFQPNLFREMQRYDMDRDLVTTRQGMYENNYYTMNLTGDARKLAHEEAGKLQAKAWDLFVNVDGAGCRKICPLPHQQLGNVMVKREDIERVDAMSCRERFEQIKDQLTEEESALLLSLILHISGGNLDNSSLWDMIRSHALAAHSSDNFEDVWLLYKLREGQSVLAKRMFDEAVNDGLDYAFSTEVASISDWGQQVEVTTPSGERFRASQVISTIPLNVLRHIRFEPPLSPLRQEAVNIGHVNFMNKIHAEVKGSGLASWNGMSFPNILMYGYGDGVLNNGNAHIVAFGTDERATGYVAEKCPEQTIEAFQKLHPMKVEKMIFHNWNTDPYSQGGPAWWAPGYMSRFQDELQSPHGNVRFASADWAHGWRAFIDGAIEQGHLNAKAVLSSLGPISARTLSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFS3</accession>
    <name>C7ZFS3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_97290</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698924">
        <property type="protein sequence ID" value="EEU36996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042709.1">
        <property type="nucleotide sequence ID" value="XM_003042663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFS3"/>
    <dbReference type="FunCoup" id="C7ZFS3">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="GeneID" id="9664825"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_97290"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_97290"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_4_2_1"/>
    <dbReference type="InParanoid" id="C7ZFS3"/>
    <dbReference type="OMA" id="WNIFCWN"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF15">
        <property type="entry name" value="TRANSPORTER SEO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="455"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU36996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="54870" checksum="D65A5D885BF039D8" modified="2009-10-13" version="1">MAGPARRKWYHIQWYSDTDTKEERKFIIKLDTLIVPYAVLAYWVKYIDQSNLNNAYVAGLKEDLGFKGNELVQLQTFYIIGAVVGQIPFFFLLTYIPIHWLLPFLDVAWGIFTLLQYRVTSFAELAAYRFLVGWFEAAFFPVMHYLFGSWYRGDEIGRRGGVFYVGLSLGTLTAGLIQAGASSRLDGVRGLEGWRWMYIICAVITIPIGILGFFVLPGTPDQPNRRVLNQHDIDVGEKRLRRAGHQSHGKMKWRDLKKVIIRPQFWGIILVDVLFWNAGIHASSGSFLLWIKSLNRFSPARVNELGTIAPALGIFYTLFVCFASDLVLGPAWAITMAHVWNIIGLIILVIWRVPEAALWFAFSTIYSAYSMSSVFHGWVNTQLRASPAERSFTLVLINAISQSSTAWTPLLVFKTVEAPRFPKGFAFCLGCAIGLLVATHILHLYLKNRDPQAEQPAALQSEENGTFPVDSKEAPVSQTRKGETSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZG13</accession>
    <name>C7ZG13_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fucose-specific lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_52084</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698924">
        <property type="protein sequence ID" value="EEU36979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042692.1">
        <property type="nucleotide sequence ID" value="XM_003042646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZG13"/>
    <dbReference type="GeneID" id="9664807"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_52084"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_52084"/>
    <dbReference type="eggNOG" id="ENOG502RVY9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028617_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZG13"/>
    <dbReference type="OMA" id="YWSNETI"/>
    <dbReference type="OrthoDB" id="4696326at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988815" description="Fucose-specific lectin" evidence="3">
        <location>
            <begin position="25"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU36979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="53157" checksum="75C25170ADC8A9C9" modified="2009-10-13" version="1">MTFLHCRLVATALYLAFSIKTARSSNLYAFYTQRSIQAAAQDPDTGRILYSNCNSLDEPVFPVENPNVLPTFSSPQNGTALAAAGWWDGTQVLASVFFQNEDGEIANCFYECDMETGRFNRTAESYPSLIARVGSVHERTGLSVELLVDQVGYRQYRLFYHNADRQIMMMSWEQDAKLWTDTGRVSQDTDHGMALASVYHEGKDISVVAPRGSGDIEVARLPQDDLWQLGSFPRPLKGNATNETAPSQMKFDDTASADFSLPFWNPNTKAIGLAVTKNGLREVYYIGTDTTLYQARESSTYGEWILGPNGSQSTWSKADERSGGIAVVSRSKVPGEVWIYYWVDGAIIQVYKSAAGIWEEAKTLPPNTTSTDVARPPVGGNGGENSGPGGWSTAMKAGVGLGVTAGVLTVGVLIWVLFNRHNALSPIFRTRGAHIEGESHSDLPELCIVQRATPISVQSARPSTARRAAELEQPGMAYELSGHTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZGK7</accession>
    <name>C7ZGK7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_42094</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698925">
        <property type="protein sequence ID" value="EEU36909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042622.1">
        <property type="nucleotide sequence ID" value="XM_003042576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZGK7"/>
    <dbReference type="GeneID" id="9670122"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_42094"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_42094"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_3_1"/>
    <dbReference type="InParanoid" id="C7ZGK7"/>
    <dbReference type="OMA" id="YWCAIFL"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF30">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04702)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
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        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
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            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
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            <end position="183"/>
        </location>
    </feature>
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        <location>
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            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="221"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU36909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="58319" checksum="0F0AE25AE0E2E701" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZGS4</accession>
    <name>C7ZGS4_FUSV7</name>
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        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_88944</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EEU36782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003042449.1"/>
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    <dbReference type="STRING" id="660122.C7ZGS4"/>
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    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88944"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="C7ZGS4"/>
    <dbReference type="OMA" id="ERCITAC"/>
    <dbReference type="OrthoDB" id="189997at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="70"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU36782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="588" mass="67148" checksum="7C8FDC691D16C332" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHG0</accession>
    <name>C7ZHG0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_69859</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EEU36535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042248.1">
        <property type="nucleotide sequence ID" value="XM_003042202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHG0"/>
    <dbReference type="STRING" id="660122.C7ZHG0"/>
    <dbReference type="GeneID" id="9669353"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_69859"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_69859"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZHG0"/>
    <dbReference type="OMA" id="TWHHRVQ"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004032">
        <property type="term" value="F:aldose reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019568">
        <property type="term" value="P:arabinose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042843">
        <property type="term" value="P:D-xylose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042180">
        <property type="term" value="P:ketone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000018">
        <property type="entry name" value="Glycerol dehydrogenase Gcy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="7">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU36535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="294" mass="32895" checksum="9525F222FF083BD6" modified="2009-10-13" version="1">MYPSRTFILNTGDEIPAVGLGTWRSNPRQVSTAVETALRAGYRHIDTALAYGNEQEVGNGIRASGVPREEIWVTSKLRNNWHKHVREGLETSLKNLGLDYVDLYLIHWPCSRDADDPANLYRDWDFVDTWAEMQRLLDGGKVRNIGVSNFGIRHLEELLNSPSTKVVPAVNQIELHPCNPSPKLVAYNTSKGIHTEGYSCLGSAHLGLSRNKILVDIANAKGKTPQQVLLQWGLQKGWSVVPKSVTPSRIESNLDLDGWELTDDEMDMLDGIETRFKVVGDGFLPKKVFFGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZI60</accession>
    <name>C7ZI60_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_52495</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GG698929">
        <property type="protein sequence ID" value="EEU36385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042098.1">
        <property type="nucleotide sequence ID" value="XM_003042052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZI60"/>
    <dbReference type="STRING" id="660122.C7ZI60"/>
    <dbReference type="GeneID" id="9674371"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_52495"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_52495"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_3_2_1"/>
    <dbReference type="InParanoid" id="C7ZI60"/>
    <dbReference type="OMA" id="EMRIRAN"/>
    <dbReference type="OrthoDB" id="47494at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF1">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="7"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="306"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU36385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="401" mass="44985" checksum="CD474FF9905B33E9" modified="2009-10-13" version="1">MVVQEKLPVIVAGAGLVGVLLGQLLKQNGIPFEIYDRDEGLGSRYGGWAISLHWIEAELKRALPEDMYERIKAGHVDPESYATGSIPFKYLDLETGEPTVSFTVPSYLRVSRFLVRSVLADGLDIQWATAVRSFESVDEGVLVRLSNGKTTRGSMLIACDGKNSVLKRSIIDPEQLDFTDLPIELVGCKVRLDPPSAKKLLAVNPIMWQGAHPRTRSFFFFSLNSTPRTNGTAETSEEYYEAQFNYSWIAIQGEEQPSTSAVRLRRLKEVGSTFFPPLREAIEAIRDDVQLLDIKIQDWLPVEWDNQGGRVTILGDAAHAMTMYRGEGVNHGMYDAIKLVEQLRLWEEGAKSLAEAVAAYEGEMRPRAREGVLLSRQACLDAHYVERVHLGHRLFGYRDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZII8</accession>
    <name>C7ZII8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_64568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698930">
        <property type="protein sequence ID" value="EEU36270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041983.1">
        <property type="nucleotide sequence ID" value="XM_003041937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZII8"/>
    <dbReference type="GeneID" id="9674305"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_64568"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_64568"/>
    <dbReference type="eggNOG" id="ENOG502S6PS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_7_1_1"/>
    <dbReference type="InParanoid" id="C7ZII8"/>
    <dbReference type="OMA" id="MKHAMLL"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU36270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="37843" checksum="5CD328303D7C3E0B" modified="2009-10-13" version="1">MEAGAFAHAATIEPIESRDRVDEVDEFPTSDYDAESVSFQAASLNSSIYQHFYENGRRYHHYRHGTYPIPNDDAEQNRDDMKHVMMLELTDGKLFFAPVGNNPQKILDLGTGTGSWAIEVADMYPSASVVGVDLSPIQPLWVPPNLKFVVDDIEDSWMLGDGYEFMHMRCISPWLKDQPTVLQQAYEHLNPGGWIEIQELDARANCDDGSLPLDSSLSKFFDTAEAAVRSFGMNFRAGEKLGELLQNVGFINVGCIVLKVPIGAWAKDQKLRLIGLYCRTAVEDMFGAMAAKPFRRIMETKDIEAFLAAARKDLYDTEIHAYEKYYFWMGQKPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJB6</accession>
    <name>C7ZJB6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_35022</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698933">
        <property type="protein sequence ID" value="EEU35875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041588.1">
        <property type="nucleotide sequence ID" value="XM_003041542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJB6"/>
    <dbReference type="STRING" id="660122.C7ZJB6"/>
    <dbReference type="GeneID" id="9673959"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_35022"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_35022"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_5_1"/>
    <dbReference type="InParanoid" id="C7ZJB6"/>
    <dbReference type="OMA" id="INKRRMP"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000156">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF316">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002989221" description="FAD-binding domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="4"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU35875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="405" mass="45098" checksum="AD6A84555AB522BF" modified="2009-10-13" version="1">MSTTKVAIIGAGLSGLTLALALHQQGIEAVAYEQQSAPLDIGGAIMLSPNALRILDKLGVFERMEPRSYKFEESYFLSEDGKTVDVFEFGSVAKYGYSGIRVYRFELINILLELVREAGIQVVYGKKFDRIVTETEDSVTWLFTDGSESTASLLVGADGIHSRVRSYLHPDLQPKFTNMIGVTAAVPTEQLNMEKDEYKLPATFMHNKRGAFVIAPQLADGSEVLIGKQRIFAGEDPGRDAWKAMTSDKTWCIDFLREGSQDFPPIVSNATSKISTDKVNLWPFYLLPKLNKWASTDKHSRVIILGDAAHAIPPTAGQGVNQAFEDVYTFARILGHLKQKGLGGSLKRWQEGRQGRIDRVIELNGEINQRRLPKEGDVEMKPFELDWLYGVDLDNMVEEFVGGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJK4</accession>
    <name>C7ZJK4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyltransferase family 32 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_88959</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698934">
        <property type="protein sequence ID" value="EEU35799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041512.1">
        <property type="nucleotide sequence ID" value="XM_003041466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJK4"/>
    <dbReference type="STRING" id="660122.C7ZJK4"/>
    <dbReference type="GeneID" id="9673876"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88959"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88959"/>
    <dbReference type="eggNOG" id="ENOG502S0TG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036369_2_0_1"/>
    <dbReference type="InParanoid" id="C7ZJK4"/>
    <dbReference type="OMA" id="MWTSYPF"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF15">
        <property type="entry name" value="INOSITOL PHOSPHOCERAMIDE MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU35799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="39686" checksum="E2BC314EA01C4C5E" modified="2009-10-13" version="1">MFPRHVFTRQFVVVGIILLAVLSLWHFQKLLYPAWTLLTLPFSWPRNSAQFLISSESDGFDLSFASYNKFQTTAAQGYSDRVPAILHHITWDSAVARATWNESRNSCLNLHPGWEHHLWTDENANQFVKENFPDFKATWDAYPFPIQRRNALKYLLLYHYGGVILDMDLKCKRALGPLRRFDFVAPAASQTGFSIDFMMASRQNELIGAIIHNLKVYNHRWFGLPYLAVLFSTGGHLASTIHASQRNRAELKILAGPPDNFTLHCLNGRASTPIFDHLHDSTLPSYNSPMSISFMSLDTCIALVLPFLIICIVGVMLVIVDRVHRAVNVWTCSWKNNLDTDLEKANPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZK59</accession>
    <name>C7ZK59_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_86820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698937">
        <property type="protein sequence ID" value="EEU35617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041330.1">
        <property type="nucleotide sequence ID" value="XM_003041284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZK59"/>
    <dbReference type="GeneID" id="9676133"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86820"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86820"/>
    <dbReference type="eggNOG" id="ENOG502SXMX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153361_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZK59"/>
    <dbReference type="OMA" id="WTPKMIR"/>
    <dbReference type="OrthoDB" id="3521506at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU35617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="115" mass="13158" checksum="E4FB3BA9827EC278" modified="2009-10-13" version="1">MGRQCKSTKKLLALFIDEIPDDKLLEFSDTPGEIYSQQNFRLDLQGKTSSGGWNLQIQVNYGAETEALQAMAPDTISGPVLVTLELPMTPEEIREEFRNKIIQPQPQPRKRKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKD8</accession>
    <name>C7ZKD8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_98211</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698938">
        <property type="protein sequence ID" value="EEU35542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041255.1">
        <property type="nucleotide sequence ID" value="XM_003041209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKD8"/>
    <dbReference type="STRING" id="660122.C7ZKD8"/>
    <dbReference type="GeneID" id="9675975"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_98211"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98211"/>
    <dbReference type="eggNOG" id="KOG4245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039329_5_0_1"/>
    <dbReference type="InParanoid" id="C7ZKD8"/>
    <dbReference type="OMA" id="NMHILGI"/>
    <dbReference type="OrthoDB" id="432010at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF31">
        <property type="entry name" value="AMIDOHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G05840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="5">
        <location>
            <begin position="68"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="5">
        <location>
            <begin position="309"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU35542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="357" mass="39991" checksum="30C1E61289D019E7" modified="2009-10-13" version="1">MPGSTIPKIALEEAFTLPELANNSNGFTGPNGGQDLVQDLLDIQVRRLERMKASGVSFMILSLTSPGPQDEADPEKALALARRANDYLAGEIQKNPSCFAGLAALSMHDPKTAAIEARRAIKSLGLVGILVNDFQTVSADGKQIVFYDQPEWDVFWKEITELDVPVYIHPRLTTPDVSKRFLAGRPGLRGSAYFFAVGVSLHVLGLYINGVFERFPNLQIIVGHMGEHLLIQLWRIDHRFSYNTGVLKPKTEKTFKEVMKTVRLTTFSQLAVFQTANEVNNRTSQSLLVGIMVLLHCFMQSRKSGYKGEVMFSIDYPYETMEQGPKWFDEITDLSQEQKEQIAWGNAKRLFKLNCGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKR4</accession>
    <name>C7ZKR4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_69901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698941">
        <property type="protein sequence ID" value="EEU35379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041092.1">
        <property type="nucleotide sequence ID" value="XM_003041046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKR4"/>
    <dbReference type="STRING" id="660122.C7ZKR4"/>
    <dbReference type="GeneID" id="9675575"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_69901"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_69901"/>
    <dbReference type="eggNOG" id="ENOG502RJ7T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022607_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZKR4"/>
    <dbReference type="OMA" id="RDKHFEH"/>
    <dbReference type="OrthoDB" id="5032844at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU35379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="614" mass="68310" checksum="7FF0BB7E8688E436" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKW9</accession>
    <name>C7ZKW9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_100803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698941">
        <property type="protein sequence ID" value="EEU35372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041085.1">
        <property type="nucleotide sequence ID" value="XM_003041039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKW9"/>
    <dbReference type="FunCoup" id="C7ZKW9">
        <property type="interactions" value="105"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZKW9"/>
    <dbReference type="GeneID" id="9675538"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100803"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100803"/>
    <dbReference type="eggNOG" id="ENOG502RNIV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022672_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZKW9"/>
    <dbReference type="OMA" id="WTFDTWN"/>
    <dbReference type="OrthoDB" id="2527403at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018803">
        <property type="entry name" value="Ish1/Msc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10281">
        <property type="entry name" value="Ish1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005669065" evidence="2">
        <location>
            <begin position="19"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU35372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="544" mass="59976" checksum="46A713327FCD9527" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLT3</accession>
    <name>C7ZLT3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_78593</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698947">
        <property type="protein sequence ID" value="EEU35014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040727.1">
        <property type="nucleotide sequence ID" value="XM_003040681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLT3"/>
    <dbReference type="GeneID" id="9679173"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78593"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78593"/>
    <dbReference type="eggNOG" id="KOG0762">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_16_1_1"/>
    <dbReference type="InParanoid" id="C7ZLT3"/>
    <dbReference type="OMA" id="WVTATPF"/>
    <dbReference type="OrthoDB" id="193856at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF10">
        <property type="entry name" value="SLC (SOLUTE CARRIER) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="109"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="208"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU35014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="35301" checksum="9593C62D5B9F1DBC" modified="2009-10-13" version="1">MSADFWAGYLSGAVGIIIGNPLDVIKVRLQAQHNTPVSNTPPNPVLGTTAAAHAISQGPSPYARYFGNSASLVTGTAAPILGYGALNALLFVSYNRTEAALNNAFSTSGNLWNTWIAGAVGGLATWVVSTPTELIKCRAQLASPPLSSWAITKQIWRNEGIRGLYFGGVVTALRDSIGYGFYFWSYELSTRWLATQPGEESSFQHEAAKVLLCGGLAGVATWASIFPLDVIKTRVQAQPWVQQAETSPLLQSNGVSRPSRTGALQIAQQAYREEGARVFFRGLTVCSVRAFMVNAVQWAVYEWVMYELGQGRKQSVSDGMQVELAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLU8</accession>
    <name>C7ZLU8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mandelate racemase/muconate lactonizing enzyme N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_99852</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mandelate racemase/muconate lactonizing enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698947">
        <property type="protein sequence ID" value="EEU35026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040739.1">
        <property type="nucleotide sequence ID" value="XM_003040693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLU8"/>
    <dbReference type="STRING" id="660122.C7ZLU8"/>
    <dbReference type="GeneID" id="9679175"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_99852"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_99852"/>
    <dbReference type="eggNOG" id="ENOG502RS4R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1938710_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZLU8"/>
    <dbReference type="OMA" id="IACWNIF"/>
    <dbReference type="OrthoDB" id="2943660at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.10:FF:000009">
        <property type="entry name" value="Hydrophobic dipeptide epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme N-terminal" evidence="5">
        <location>
            <begin position="38"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU35026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="130" mass="14331" checksum="3251F3731DFECE66" modified="2009-10-13" version="1">MSELKIAKIDVFQAELPYSGGVYRLSGGREYRSFDGTFVRITTNTGIEGWGESTPFGSTYIAAHALGVRAGIAEIAPWLIGLDPRRLDRINEAMDAALVGHEHAKTPIDIACWDIFEMRKQEQAPAHPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZM01</accession>
    <name>C7ZM01_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LamG-like jellyroll fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_78537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698948">
        <property type="protein sequence ID" value="EEU34959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040672.1">
        <property type="nucleotide sequence ID" value="XM_003040626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZM01"/>
    <dbReference type="GeneID" id="9679101"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78537"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78537"/>
    <dbReference type="HOGENOM" id="CLU_003772_2_1_1"/>
    <dbReference type="InParanoid" id="C7ZM01"/>
    <dbReference type="OMA" id="WFIRANS"/>
    <dbReference type="OrthoDB" id="2588159at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF045579">
        <property type="entry name" value="rhamnoside_JR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43817">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43817:SF1">
        <property type="entry name" value="HYDROLASE, FAMILY 43, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17132">
        <property type="entry name" value="Glyco_hydro_106"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU34959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="907" mass="99359" checksum="F09FB6A84237F815" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZM97</accession>
    <name>C7ZM97_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_55084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698950">
        <property type="protein sequence ID" value="EEU34855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040568.1">
        <property type="nucleotide sequence ID" value="XM_003040522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZM97"/>
    <dbReference type="STRING" id="660122.C7ZM97"/>
    <dbReference type="GeneID" id="9678987"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55084"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55084"/>
    <dbReference type="eggNOG" id="ENOG502RTJ4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002341_2_0_1"/>
    <dbReference type="InParanoid" id="C7ZM97"/>
    <dbReference type="OMA" id="IANFRTR"/>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056693">
        <property type="entry name" value="DUF7791"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="294"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU34855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="974" mass="109239" checksum="CC59CA4AFD18B7B0" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZN45</accession>
    <name>C7ZN45_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_88861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698962">
        <property type="protein sequence ID" value="EEU34571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040284.1">
        <property type="nucleotide sequence ID" value="XM_003040238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZN45"/>
    <dbReference type="GeneID" id="9678705"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88861"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88861"/>
    <dbReference type="HOGENOM" id="CLU_897384_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZN45"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="268"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU34571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="310" mass="33523" checksum="64C6809533371625" modified="2009-10-13" version="1">MAVSPAGSVGSTKRSLSLEDEDYFSPVESSDDKIEQTSPVLYPAATRTSTADAETLPPTSSVDIPLAVPAQQTTPNAGTLPSFGSLNTPLASLAQQTTPLAAYFSNTGCPDKPYFSTSASRWCINGPNNISPRRDKAFRDVVLNRDDTDWSPGNQSQPSPSTSRPQPPALGLQHGHGVQKTLEKIVEASNHVERYSPGMPCQKPPPGPSSKLSPLSASKSLPLPPSTPLTPSVKRPRPAADDLGDTPPAKQVGKYLKKYGVRKEYEDYMEHKAKSKMLRKKIEELEDELVQSEDKEQSALERLQAKCNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNT5</accession>
    <name>C7ZNT5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_85535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039963.1">
        <property type="nucleotide sequence ID" value="XM_003039917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNT5"/>
    <dbReference type="GeneID" id="9677691"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85535"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85535"/>
    <dbReference type="eggNOG" id="ENOG502SN86">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002639_3_2_1"/>
    <dbReference type="InParanoid" id="C7ZNT5"/>
    <dbReference type="OMA" id="QAFAESW"/>
    <dbReference type="OrthoDB" id="5362512at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="201"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="705" mass="79056" checksum="CEB903263CC14BB4" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNX5</accession>
    <name>C7ZNX5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_85576</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039987.1">
        <property type="nucleotide sequence ID" value="XM_003039941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNX5"/>
    <dbReference type="GeneID" id="9677922"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85576"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85576"/>
    <dbReference type="eggNOG" id="ENOG502RAIJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029473_3_1_1"/>
    <dbReference type="InParanoid" id="C7ZNX5"/>
    <dbReference type="OMA" id="ETVVEWR"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU34274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="53225" checksum="C594E247B2F1B236" modified="2009-10-13" version="1">MEQLAPEILSSIALCLWEDSEESLAPFATLSRQWQPYIEAQTFRRLFLNPTRLSEAISQSILTPTRLSCLRYLRCEFIFPAHETDSTNPDDADDEIVFVKIVTQLFSLLSKTPPCKDPLVYLCLEIPVPGVFGSSEQYASDYGEPVDYPFVAQGQVRTSYLDFPPGYEEELPELPMVYKMSTNLISRSVVFSPRSICLIASKMPRLRKVNWELSDAEKLDTGLAGTLKRLPMSIEMFHLTYVRELPNNHSFQPPSIIPPDSQQDPLSEALCEFTQRIGLKDFTFSGSVDHTIFWPSSESSDEQPYWPSLKSIDVYPHEVLPSGEWLTMQRPGSRLPPSVMIHLAADIPGEGLERRFRDYPVYSLMDPFFRNMGKCVARMPKVEYCSISFSDAWLSNLHFCTEFPEIPCLVLAGKPEPEVGKETSDIWREAVKVHNKDFRLHFNADDPFSLKHFSGVYEEMDVGENSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPP1</accession>
    <name>C7ZPP1_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_50214</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase e1/e2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039885.1">
        <property type="nucleotide sequence ID" value="XM_003039839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZPP1"/>
    <dbReference type="FunCoup" id="C7ZPP1">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZPP1"/>
    <dbReference type="GeneID" id="9677606"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_50214"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_50214"/>
    <dbReference type="eggNOG" id="ENOG502S76V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170555_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZPP1"/>
    <dbReference type="OMA" id="WAITYLC"/>
    <dbReference type="OrthoDB" id="1508846at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008389">
        <property type="entry name" value="ATPase_V0-cplx_e1/e2_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05493">
        <property type="entry name" value="ATP_synt_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU34172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="71" mass="8006" checksum="4BF5404CD3758CCA" modified="2009-10-13" version="1" fragment="single">YAVFIGLVVIAALCVASWLLAPKGENQVLWRSSLILAIVSCYLMWAITFMAQLHPLIAPRRTGIREEYLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPT7</accession>
    <name>C7ZPT7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_54475</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698973">
        <property type="protein sequence ID" value="EEU33964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039677.1">
        <property type="nucleotide sequence ID" value="XM_003039631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZPT7"/>
    <dbReference type="GeneID" id="9677503"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_54475"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_54475"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_1_1"/>
    <dbReference type="InParanoid" id="C7ZPT7"/>
    <dbReference type="OMA" id="LCGTELF"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF12">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU33964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="59442" checksum="39DFCB5B01DCB4C5" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQB3</accession>
    <name>C7ZQB3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ABC transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_56041</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698987">
        <property type="protein sequence ID" value="EEU33797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039510.1">
        <property type="nucleotide sequence ID" value="XM_003039464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQB3"/>
    <dbReference type="GeneID" id="9667027"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_56041"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_56041"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_17_2_1"/>
    <dbReference type="InParanoid" id="C7ZQB3"/>
    <dbReference type="OMA" id="ADGENRN"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000251">
        <property type="entry name" value="ABC transporter B family member 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000916">
        <property type="entry name" value="ABC transporter B family member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF11">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="698"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="741"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="822"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="846"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="928"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="960"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="55"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="383"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="700"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1026"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="630"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="637"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU33797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1274" mass="138091" checksum="560C8022868AE216" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQK6</accession>
    <name>C7ZQK6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_89231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698999">
        <property type="protein sequence ID" value="EEU33694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039407.1">
        <property type="nucleotide sequence ID" value="XM_003039361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQK6"/>
    <dbReference type="GeneID" id="9666932"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89231"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89231"/>
    <dbReference type="HOGENOM" id="CLU_1384484_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZQK6"/>
    <dbReference type="OrthoDB" id="5028325at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU33694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="197" mass="22004" checksum="0CF1DF5F062F560B" modified="2009-10-13" version="1">MDEPKILLAELADLEELVNPSTADDSDDGGLDSYAGIGFVDELYASVDDEEVRSSNIGRDDFKIRHSSGNFKMKPTVLTLVDHFLAQTNESNFDASQALEMFQRRYTMDYGRRASGSKAADPDDKYFPIFHLGMIGIVGRPLRPITNRSGFFDKVTFTLRYWHSSYVGKHVTTNLPFDIRNRTFRIATAASGNSGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQL9</accession>
    <name>C7ZQL9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycogen debranching enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_56248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699001">
        <property type="protein sequence ID" value="EEU33687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039400.1">
        <property type="nucleotide sequence ID" value="XM_003039354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQL9"/>
    <dbReference type="GeneID" id="9666924"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_56248"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_56248"/>
    <dbReference type="eggNOG" id="ENOG502QV7E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012888_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZQL9"/>
    <dbReference type="OMA" id="WSWQLAM"/>
    <dbReference type="OrthoDB" id="2591256at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002989487" description="Glycogen debranching enzyme" evidence="1">
        <location>
            <begin position="21"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU33687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="751" mass="82254" checksum="EE6698D78DA924EA" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQM2</accession>
    <name>C7ZQM2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Up-regulated during septation protein 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_56263</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699002">
        <property type="protein sequence ID" value="EEU33682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039395.1">
        <property type="nucleotide sequence ID" value="XM_003039349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQM2"/>
    <dbReference type="STRING" id="660122.C7ZQM2"/>
    <dbReference type="GeneID" id="9666920"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_56263"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_56263"/>
    <dbReference type="eggNOG" id="ENOG502S13H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013725_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZQM2"/>
    <dbReference type="OMA" id="HIANCMR"/>
    <dbReference type="OrthoDB" id="5429395at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029191">
        <property type="entry name" value="Uds1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15456">
        <property type="entry name" value="Uds1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Up-regulated during septation protein 1" evidence="3">
        <location>
            <begin position="355"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="479"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="590"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="435"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="479"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="513"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="590"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU33682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="611" mass="67487" checksum="6EE4F43D4D867F40" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7YH16</accession>
    <name>C7YH16_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="8">5.1.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Pentose-5-phosphate 3-epimerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">RPE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NECHADRAFT_74815</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate degradation; pentose phosphate pathway; D-xylulose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="8"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054268.1">
        <property type="nucleotide sequence ID" value="XM_003054222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YH16"/>
    <dbReference type="FunCoup" id="C7YH16">
        <property type="interactions" value="481"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YH16"/>
    <dbReference type="GeneID" id="9664424"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74815"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74815"/>
    <dbReference type="eggNOG" id="KOG3111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054856_0_0_1"/>
    <dbReference type="InParanoid" id="C7YH16"/>
    <dbReference type="OMA" id="CHLMIED"/>
    <dbReference type="OrthoDB" id="1927044at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000130">
        <property type="entry name" value="Ribulose-phosphate 3-epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004076">
        <property type="entry name" value="PRK05581.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="RIBULOSE-5-PHOSPHATE-3-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0170">Cobalt</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU48555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="313" mass="34101" checksum="4C12C4C95D03F18A" modified="2009-10-13" version="1">MAPKTIIAPSILSADFAQFGHDCARTMEQGADWLHVDIMDGHFVPNITFGPPVVASIRGHVDQPTEALGRGTFDCHMMIAEPKKWVKEFKKAGCNLYCFHYEAAFSSDAESPEQKTDDKTNPKALIRYIHDNGLLAGIAIKPDTSVDVLWEILENAKEQERPDMVLIMTVYPGFGGQKFMASELPKVQALREKYPELNIEVDGGLGPGTIDQAADAGANVIVAGSAVFGAKDPSEVISLLRKSVDDRKAKRELSDDCFLSSHLPALIDSFGDQIKAVELSNHHHGSSVSAPVAAPREYNSVQQTETLQTAIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7YI82</accession>
    <name>C7YI82_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_75228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053767.1">
        <property type="nucleotide sequence ID" value="XM_003053721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YI82"/>
    <dbReference type="GeneID" id="9664524"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75228"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75228"/>
    <dbReference type="eggNOG" id="ENOG502T63T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_765238_0_0_1"/>
    <dbReference type="InParanoid" id="C7YI82"/>
    <dbReference type="OrthoDB" id="10420436at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU48054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="362" mass="39933" checksum="DABBA2404A9D1245" modified="2009-10-13" version="1">MANPKEEGSTDPYKITLSHFGDAMKNSPSRRKPVQRVLDLYDKIRRGGNMNQEVQEKFFNDISDIKWATSLKTAVSTHGSYKALKGNGGRHENRRFSNWVIVSACWPDADKLPDIRANMAKYWGLKIFPDGEFPKVAVDKQLTLYLGKLEKKHPSKSKSRTIGSATDPKGKGPQTPNQGGDHGSIDGDSSGGESEDEAIIDEESTTAAQKARDKSLKEEAQKERNSNPDQVEKASGSSGLATMEKIEKARANVSKAYANRGAKRPADPTPATDSPPAKRASTHSALDRQAIALADLLRDLPSNSERLQKLEEENDQLREENRQLKERIDKAEAAHEKETMDTLLVLLDVAQRKVASEATKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C7YID9</accession>
    <name>C7YID9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_75285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054500.1">
        <property type="nucleotide sequence ID" value="XM_003054454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YID9"/>
    <dbReference type="GeneID" id="9676421"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75285"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75285"/>
    <dbReference type="HOGENOM" id="CLU_1503829_0_0_1"/>
    <dbReference type="InParanoid" id="C7YID9"/>
    <dbReference type="OrthoDB" id="10483098at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU48787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="179" mass="19859" checksum="6B6DB518473EA3E5" modified="2009-10-13" version="1">MAVKVVRGLDLASKLFAPGFSASLVCSVPTAGSRGSIGGVEVFKLDVSLQLVDDDVNGRTALQDTSYHRGNDPADVAGLFVDAFVAWISPPLTFIRRVRGRNRSFWIPDIVSLLMEGTYGMERGLTDRTVADRGPPRWDAPGVLQCWTARPSRHHTYERHDYAFDHEQEKDMVVYGMTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIK1</accession>
    <name>C7YIK1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_30904</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053820.1">
        <property type="nucleotide sequence ID" value="XM_003053774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIK1"/>
    <dbReference type="FunCoup" id="C7YIK1">
        <property type="interactions" value="942"/>
    </dbReference>
    <dbReference type="GeneID" id="9676456"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_30904"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_30904"/>
    <dbReference type="eggNOG" id="ENOG502QTEH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011881_1_0_1"/>
    <dbReference type="InParanoid" id="C7YIK1"/>
    <dbReference type="OMA" id="RTFPVCS"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF7">
        <property type="entry name" value="PROTEIN STB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="77"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="137"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU48107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="728" mass="80106" checksum="DB36FD6C4C59B49E" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7YL81</accession>
    <name>C7YL81_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_77437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052925.1">
        <property type="nucleotide sequence ID" value="XM_003052879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YL81"/>
    <dbReference type="GeneID" id="9670988"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77437"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77437"/>
    <dbReference type="HOGENOM" id="CLU_1245687_0_0_1"/>
    <dbReference type="InParanoid" id="C7YL81"/>
    <dbReference type="OMA" id="RDVEMIM"/>
    <dbReference type="OrthoDB" id="5101763at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU47212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="222" mass="24808" checksum="8EFD45D95952E9D0" modified="2009-10-13" version="1">MYAGNVFQEEENGEGESLVRVREERGTRSGKVFKNWSSNQRSNPAPVWRDPKFSETSIEVGVLGVNHPEPGSDIIPEIPLSSARAAGAPTMLGLTLNLEEGSYAFLWRDSNCKFINPKYVRLNDEYTMATARATAIEHYNGRAIARIMSFNTDLIISAARRRIRKWAVSGSQTRADLDEEDIVTAGEVRKLVFASDFLAECQIALQETMQELSGRDPFVLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7YMC7</accession>
    <name>C7YMC7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="8">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NECHADRAFT_91944</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HDDC2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="8"/>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053141.1">
        <property type="nucleotide sequence ID" value="XM_003053095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YMC7"/>
    <dbReference type="FunCoup" id="C7YMC7">
        <property type="interactions" value="487"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YMC7"/>
    <dbReference type="GeneID" id="9664057"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_91944"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_91944"/>
    <dbReference type="eggNOG" id="KOG3197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039453_2_0_1"/>
    <dbReference type="InParanoid" id="C7YMC7"/>
    <dbReference type="OMA" id="VEYREQG"/>
    <dbReference type="OrthoDB" id="10254258at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009159">
        <property type="term" value="P:deoxyribonucleoside monophosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000011">
        <property type="entry name" value="HD domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845:SF13">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0170">Cobalt</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="14">
        <location>
            <begin position="63"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU47428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="243" mass="27047" checksum="AB4ACEFD6F3CDD62" modified="2009-10-13" version="1">MPETAPTGISTSPDAAEPWTVEKALAGNDLVQGSKSPISLFHLLGGLKTTKREGWKRHGINTSPESVADHSYRMGMIAMFAPQGLDQVKCMKMCMIHDVAESVVGDITPFSGVSKTEKARRETATIEYIATRWGGHHTSELRELWHEFEAAETPEAQFAQDIDKIDLMLQAVEYEKDGKGQRDLGEFMGVARKLRTEAGKAWAEEILLEREKLWEGREHVRGEQAEKGGVSTEAQKLQDAYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7YMK5</accession>
    <name>C7YMK5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_35638</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052677.1">
        <property type="nucleotide sequence ID" value="XM_003052631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YMK5"/>
    <dbReference type="STRING" id="660122.C7YMK5"/>
    <dbReference type="GeneID" id="9664094"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_35638"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_35638"/>
    <dbReference type="eggNOG" id="ENOG502SKH5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_8_4_1"/>
    <dbReference type="InParanoid" id="C7YMK5"/>
    <dbReference type="OMA" id="VEPFVRM"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF30">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="5"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU46964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="308" mass="34391" checksum="F10882D261191B34" modified="2009-10-13" version="1">MSDLKVFVCGATGCQGGAVARYLRSKDVEVHALVRDPTSKKAHDLESIGVKLTPGDYDNKEAIETAMAGCTAIFLVLMPDFTDLTKERTWAKNIYSAGKAAGVKHAVFSSGFGANEPDKLTAVKPGSFLDTVMRNKTAIEIETRTAGFEYWTILRPGNFMANYFEPFVMMYPGLVKEGVWTTALTPTTVLPKVDTVTIGRFGGEALLNPERFHEKEILYADEWLTPDEVMEKLSKAVGRELKTNYLTEEEINAQMDTNPFINGQLVMRDMGKFTTLEEVKKWGIPLSSFDEFLEREKDAIRETYHKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7YMW6</accession>
    <name>C7YMW6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_78022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052734.1">
        <property type="nucleotide sequence ID" value="XM_003052688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YMW6"/>
    <dbReference type="GeneID" id="9664223"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78022"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78022"/>
    <dbReference type="eggNOG" id="ENOG502SQ0K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089360_0_0_1"/>
    <dbReference type="InParanoid" id="C7YMW6"/>
    <dbReference type="OMA" id="STVWIKS"/>
    <dbReference type="OrthoDB" id="2326446at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="58"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU47021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="220" mass="25542" checksum="6D0C8295A641BA7A" modified="2009-10-13" version="1">MSLATRQDQLLLVPWDPESPDHVARLFEQRLQCGWNQELVEKKWRDKQRSGHKCIYWITLSPQDPGTQESLQSHFDVFPAPRTPTQEPIYPVGHISLDDENLEAAHLGLDFPETGVFWIKTFYVSKALQSKGIGRAAMDIAEAMAVNEPLCAKTLALDTLHKDSAKRMALEETGQVLKTTNHEWYERRGYRLIHEQHNHYWDAHREAPDMWTVFLRRDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7YN50</accession>
    <name>C7YN50_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_36480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053273.1">
        <property type="nucleotide sequence ID" value="XM_003053227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YN50"/>
    <dbReference type="STRING" id="660122.C7YN50"/>
    <dbReference type="GeneID" id="9671309"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_36480"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_36480"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014280_1_1_1"/>
    <dbReference type="InParanoid" id="C7YN50"/>
    <dbReference type="OMA" id="FGQWTIT"/>
    <dbReference type="OrthoDB" id="63070at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000557">
        <property type="entry name" value="WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051859">
        <property type="entry name" value="DCAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847:SF7">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="357"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="404"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU47560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="640" mass="73072" checksum="781CB756EE027109" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7YN62</accession>
    <name>C7YN62_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ML-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_99752</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052781.1">
        <property type="nucleotide sequence ID" value="XM_003052735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YN62"/>
    <dbReference type="STRING" id="660122.C7YN62"/>
    <dbReference type="GeneID" id="9664347"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_99752"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_99752"/>
    <dbReference type="eggNOG" id="ENOG502R5MY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009253_0_0_1"/>
    <dbReference type="InParanoid" id="C7YN62"/>
    <dbReference type="OMA" id="GCFQAVM"/>
    <dbReference type="OrthoDB" id="5377623at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF7">
        <property type="entry name" value="TRP-LIKE ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002987426" description="ML-like domain-containing protein" evidence="9">
        <location>
            <begin position="27"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="602"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="632"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="665"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="10">
        <location>
            <begin position="51"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="755"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="837"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="867"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="902"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="915"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU47068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="936" mass="103713" checksum="65AD0F55EE0897E3" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>C7YP27</accession>
    <name>C7YP27_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein 14 C-terminal Fig4-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_67966</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAC14 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051932.1">
        <property type="nucleotide sequence ID" value="XM_003051886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YP27"/>
    <dbReference type="FunCoup" id="C7YP27">
        <property type="interactions" value="892"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YP27"/>
    <dbReference type="GeneID" id="9672842"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_67966"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_67966"/>
    <dbReference type="eggNOG" id="KOG0212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007740_0_0_1"/>
    <dbReference type="InParanoid" id="C7YP27"/>
    <dbReference type="OMA" id="QCYQHVS"/>
    <dbReference type="OrthoDB" id="5574975at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026825">
        <property type="entry name" value="Vac14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021841">
        <property type="entry name" value="VAC14_Fig4p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023:SF0">
        <property type="entry name" value="PROTEIN VAC14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023">
        <property type="entry name" value="TAX1 BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12755">
        <property type="entry name" value="Vac14_Fab1_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11916">
        <property type="entry name" value="Vac14_Fig4_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="5">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein 14 C-terminal Fig4-binding" evidence="7">
        <location>
            <begin position="585"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="285"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="419"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="816"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU46219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="890" mass="99729" checksum="2ABA750E2A977B56" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7YP38</accession>
    <name>C7YP38_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THUMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_78627</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051940.1">
        <property type="nucleotide sequence ID" value="XM_003051894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YP38"/>
    <dbReference type="FunCoup" id="C7YP38">
        <property type="interactions" value="852"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YP38"/>
    <dbReference type="GeneID" id="9673093"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78627"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78627"/>
    <dbReference type="eggNOG" id="KOG3943">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039352_2_0_1"/>
    <dbReference type="InParanoid" id="C7YP38"/>
    <dbReference type="OMA" id="MNEKACV"/>
    <dbReference type="OrthoDB" id="367221at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11717">
        <property type="entry name" value="THUMP_THUMPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2300.10">
        <property type="entry name" value="THUMP superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452">
        <property type="entry name" value="THUMP DOMAIN CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452:SF10">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="3">
        <location>
            <begin position="183"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU46227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="298" mass="32746" checksum="87871FC06C38B342" modified="2009-10-13" version="1">MSDGANKRKQGPGGSGQANKKSKGGSAGKWQTPHQKAKQTEKVELGRTLEINDAGIWVTYARGMKGKAVREFRALCDEYGESLFGIKPPAEDGEGEDEDEEPKDIEASIQQELADMSAKKPKTKQFFTPISTNLDCVFFMKLQKPAEPLEMVKRICQDAKDCPDPRQRKVKYINRLTPVFDTDRATDKGIERVARTVMAPFFELKSESGEDTAEKAAASQDDGEGPASCTYAIRHTIRNHTAFKSSVVIKMIADMVSPKHKVNLTSPDKVVLVEIFQLVPQKEEEPAGAEGAAPAEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPD0</accession>
    <name>C7YPD0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hsp70 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_38229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051990.1">
        <property type="nucleotide sequence ID" value="XM_003051944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YPD0"/>
    <dbReference type="STRING" id="660122.C7YPD0"/>
    <dbReference type="GeneID" id="9668613"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_38229"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_38229"/>
    <dbReference type="eggNOG" id="ENOG502SM4S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009958_3_0_1"/>
    <dbReference type="InParanoid" id="C7YPD0"/>
    <dbReference type="OMA" id="FQRLKCA"/>
    <dbReference type="OrthoDB" id="2394218at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42749">
        <property type="entry name" value="CELL SHAPE-DETERMINING PROTEIN MREB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42749:SF1">
        <property type="entry name" value="CELL SHAPE-DETERMINING PROTEIN MREB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU46277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="580" mass="64365" checksum="16BFB1EC1182698C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPR6</accession>
    <name>C7YPR6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferroxidase</fullName>
            <ecNumber evidence="3">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_78848</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the frataxin family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="3"/>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052052.1">
        <property type="nucleotide sequence ID" value="XM_003052006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YPR6"/>
    <dbReference type="FunCoup" id="C7YPR6">
        <property type="interactions" value="427"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YPR6"/>
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    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78848"/>
    <dbReference type="eggNOG" id="KOG3413">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080880_0_0_1"/>
    <dbReference type="InParanoid" id="C7YPR6"/>
    <dbReference type="OMA" id="YSEHYFN"/>
    <dbReference type="OrthoDB" id="1897642at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:ferrous iron binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:ferroxidase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:iron chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial chaperone Frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="entry name" value="Frataxin/CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017789">
        <property type="entry name" value="Frataxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020895">
        <property type="entry name" value="Frataxin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03421">
        <property type="entry name" value="FeS_CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03422">
        <property type="entry name" value="mito_frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821">
        <property type="entry name" value="FRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821:SF2">
        <property type="entry name" value="FRATAXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="Frataxin/Nqo15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01344">
        <property type="entry name" value="FRATAXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0409">Iron storage</keyword>
    <keyword evidence="6" id="KW-0410">Iron transport</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU46339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="205" mass="22689" checksum="64947EA6B9B783C9" modified="2009-10-13" version="1">MSRQVASQASRLASRAIRTSTPLCRSSFRLAPVASRIHLPARAGVLRSYFSTAPARTRGIMPDTENPAKPLDESEDVQPSAAVAELTDGEYHELADEYLDNVVGKFEELQDEREDIDVEFSSGVLTISWPDKGTYVINKQPPNKQIWLSSPISGPKRYDWCIFGEGQNEKEGTAVGDWIYARDGSSLNQVFLEELGVDIDVPGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPX5</accession>
    <name>C7YPX5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U3 small nucleolar RNA-associated protein 6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_60024</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051638.1">
        <property type="nucleotide sequence ID" value="XM_003051592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YPX5"/>
    <dbReference type="FunCoup" id="C7YPX5">
        <property type="interactions" value="287"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YPX5"/>
    <dbReference type="GeneID" id="9673386"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_60024"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_60024"/>
    <dbReference type="eggNOG" id="KOG2396">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026025_3_1_1"/>
    <dbReference type="InParanoid" id="C7YPX5"/>
    <dbReference type="OMA" id="YAKLEMI"/>
    <dbReference type="OrthoDB" id="28112at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013949">
        <property type="entry name" value="Utp6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055347">
        <property type="entry name" value="UTP6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08640">
        <property type="entry name" value="U3_assoc_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 N-terminal" evidence="7">
        <location>
            <begin position="12"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU45925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="394" mass="45380" checksum="DF057710B0474083" modified="2009-10-13" version="1">MAGVAEKARFYLERAVPQLREWEEKEIFSKDEIRTIVQKRNDYEHKVLSPGNKPSDWASYAQWEQSLESLRSKRCKRLKIRHLNSAHAGQTRTLAIYDRGVNRHPGSGALWREYLSYTSSVKASKRWRKTMTNALRMMPTDPELWAMAGRRSAKNGDMAAARGFFMRGCRFCTTNEKLWVEYARSEMEWLEKVDKRKEAAKPGHDVLRPDRIEDGDELRLIDSDDEDDEHLPEPSKSQAKVIDKQSAQQLASNPAMDGAIPMAIFDISRKQAFFNANVAETFFELFASFNKLASQPKISQHVLDVLDQEYPKHPATCNVHIRKPIIGVNPQTAEFPMNLREVLARLNQYLSETTDQAELQRKTVAWIDGYLALENLDESIRLVLEHTKKKMVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQB9</accession>
    <name>C7YQB9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_79051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052154.1">
        <property type="nucleotide sequence ID" value="XM_003052108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQB9"/>
    <dbReference type="STRING" id="660122.C7YQB9"/>
    <dbReference type="GeneID" id="9668940"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79051"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79051"/>
    <dbReference type="eggNOG" id="ENOG502SP0F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048303_0_0_1"/>
    <dbReference type="InParanoid" id="C7YQB9"/>
    <dbReference type="OMA" id="WDGELWK"/>
    <dbReference type="OrthoDB" id="2245989at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF5">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU46441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="449" mass="49769" checksum="D39601BE17ACB977" modified="2009-10-13" version="1">MNNKSAQVKKTKAPAKRNSEARREQNRIASRNYREKRKQKLALLNQILEPSVSELANVVDGQGGSNDTTLPQTTTSGATVVDPIASIDTSAIDQDGFTESLFPDDTWGDLTASAIPASNVPFAQPFPNSLPFPFTPVDDPFAPIGVNPWATNTFRPQQLVQFSGDYVNTGIVQEISEDSPESTDQEGQPESLAPTTQDDRALKSILNGVETLTLSQKRSLLRHLQQETQDTPSKPPRAWPPTRAQMESLNKFTKALYNAANAGPTPLPAQYIVEAGLFGAIYANCYALGMGGIEEILCEEGCSIFSVTADEGHEPSQLPLVRTRFRNVTPDLRPTDLQLTFGHHPYVDVIPFRSFRDNIIKALLHDPPLVDEDILCQDLLAGGFTCWGSRRSPLGMNAGVPWDARSWEPSIWFLIKYRQLTGGWDDEMWKSARWWHSHTQRADQGNPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQF7</accession>
    <name>C7YQF7_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_37905</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052175.1">
        <property type="nucleotide sequence ID" value="XM_003052129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQF7"/>
    <dbReference type="GeneID" id="9673553"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_37905"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_37905"/>
    <dbReference type="eggNOG" id="ENOG502SJP4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003334_1_0_1"/>
    <dbReference type="InParanoid" id="C7YQF7"/>
    <dbReference type="OMA" id="AVWWFLR"/>
    <dbReference type="OrthoDB" id="4356615at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056030">
        <property type="entry name" value="DUF7611"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056031">
        <property type="entry name" value="DUF7612"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056032">
        <property type="entry name" value="DUF7613"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056033">
        <property type="entry name" value="DUF7614"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24586">
        <property type="entry name" value="DUF7611"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24587">
        <property type="entry name" value="DUF7612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24588">
        <property type="entry name" value="DUF7613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24589">
        <property type="entry name" value="DUF7614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7611" evidence="2">
        <location>
            <begin position="520"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7612" evidence="3">
        <location>
            <begin position="677"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7613" evidence="4">
        <location>
            <begin position="813"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7614" evidence="5">
        <location>
            <begin position="968"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU46462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1115" mass="124010" checksum="A61AA1778D476223" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>C7YTL4</accession>
    <name>C7YTL4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Elongation factor 1-gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_48615</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049976.1">
        <property type="nucleotide sequence ID" value="XM_003049930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YTL4"/>
    <dbReference type="FunCoup" id="C7YTL4">
        <property type="interactions" value="1287"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YTL4"/>
    <dbReference type="GeneID" id="9675142"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_48615"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_48615"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_3_0_1"/>
    <dbReference type="InParanoid" id="C7YTL4"/>
    <dbReference type="OMA" id="TQYFSWT"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03181">
        <property type="entry name" value="GST_C_EF1Bgamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03044">
        <property type="entry name" value="GST_N_EF1Bgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000006">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000142">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1010:FF:000001">
        <property type="entry name" value="Elongation factor 1-gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1010">
        <property type="entry name" value="Translation elongation factor EF1B, gamma chain, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001662">
        <property type="entry name" value="EF1B_G_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036433">
        <property type="entry name" value="EF1B_G_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00647">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01183">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89942">
        <property type="entry name" value="eEF1-gamma domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50040">
        <property type="entry name" value="EF1G_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="7">
        <location>
            <begin position="2"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="8">
        <location>
            <begin position="93"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="EF-1-gamma C-terminal" evidence="6">
        <location>
            <begin position="261"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="216"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU44263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="47624" checksum="7096BA27EB096F21" modified="2009-10-13" version="1">MAFGTLFTRENNARSTAIRAVAKANDIELNIVEAEKGNPTVEHLKANGLGKIPAFVGEDGFALSECIAIAIYTLLTPPIVTSQNEKTTLLGKTKQDYASILKWLSFFNSEVLPRLGAWIEPLKGVVPYNKKNVDEASKAALKAFDVVEDHLIRNTYLVGERITLADLFAASITLRGFQYFFDKTYREEHPALTRWFETVRSQPIFSEVAEQVELLETPALTNTPPKKPEQPKKEAAPKKEKEAPAAAAAPAGEDAPAPPKPKHPLELLGKPSFPLDEWKRQYSNIKNHDEAMKYFWENFNFEEWSIWKIDYKYNDELTLTFMSNNLIGGFNNRLEGSRKYIFGCAAVYGENNDSVIQGAFVIRGQEYLPAFDVAPDYESYEFTKLDPTKPEDRQFVEDAWGWEKGIKVGDKEYALADGKVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7YUQ2</accession>
    <name>C7YUQ2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_993</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050163.1">
        <property type="nucleotide sequence ID" value="XM_003050117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YUQ2"/>
    <dbReference type="GeneID" id="9674948"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_993"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_993"/>
    <dbReference type="eggNOG" id="KOG4629">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010480_1_0_1"/>
    <dbReference type="InParanoid" id="C7YUQ2"/>
    <dbReference type="OMA" id="FWWLGIE"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016688">
        <property type="entry name" value="MscS-like_plants/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058650">
        <property type="entry name" value="Msy1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323:SF15">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25886">
        <property type="entry name" value="Msy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017209">
        <property type="entry name" value="Memb_At2g17000_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="367"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="636"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="693"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="712"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU44450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="731" mass="83457" checksum="6E9CB4B492530F9D" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7YV37</accession>
    <name>C7YV37_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_85139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050630.1">
        <property type="nucleotide sequence ID" value="XM_003050584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YV37"/>
    <dbReference type="GeneID" id="9675011"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85139"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85139"/>
    <dbReference type="HOGENOM" id="CLU_618333_0_0_1"/>
    <dbReference type="InParanoid" id="C7YV37"/>
    <dbReference type="OrthoDB" id="5106001at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU44917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="443" mass="49374" checksum="A5F2E871929F133F" modified="2009-10-13" version="1">MFPGGGYGRGGQYFGPAYDLYGEGGSRGGGWGRGRRQRRRRGHGAGWQGGRGGFPAAHLGQNHGQGYGQEDYEEEDYGQEGYDGNQNGGQDLREQLRQRDEALRSKEEEVRSLRRALAEKNEAFQSKVEELESVRGTLAEMNEANKRLEKEKDQVIAQKNGKIRSAEAQRESAIQARSDLRSKAVRIIKDLQGKEAEAKKDAAQARTELQSANEVVAEQTAQIEALQNMLKDHEDGMHRSSTQGAATVPGPEVELLTEASEYTQAHDTITRWKEWFQFVEDDEFHDARTMADLVAILAEAQPRGRLYEFLTVGPLDEWLCLSRVCENKFAITANLCCRAPGGYGVACRAVMVTIIDSMQLVDALERVWHGRAKMMKQSIIGTLSLARDAWKGGCRSMVGVSFSGIKPMPEKESQPRRSTRVWRGTKRRTEGKFSVKTTADRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVI9</accession>
    <name>C7YVI9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">nitrilase</fullName>
            <ecNumber evidence="4">3.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_29975</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a nitrile + 2 H2O = a carboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18379"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="EC" id="3.5.5.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.5.1" evidence="4"/>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049716.1">
        <property type="nucleotide sequence ID" value="XM_003049670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVI9"/>
    <dbReference type="STRING" id="660122.C7YVI9"/>
    <dbReference type="GeneID" id="9677291"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_29975"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_29975"/>
    <dbReference type="eggNOG" id="KOG0805">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_6_0_1"/>
    <dbReference type="InParanoid" id="C7YVI9"/>
    <dbReference type="OMA" id="GAIMNTP"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF14">
        <property type="entry name" value="ARYLACETONITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00920">
        <property type="entry name" value="NITRIL_CHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00921">
        <property type="entry name" value="NITRIL_CHT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="6">
        <location>
            <begin position="9"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00036406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU44003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="248" mass="27192" checksum="2AD2DF6E1E0DDF27" modified="2009-10-13" version="1">MTQFKQKHVRVAVTQAEPIWLDLAGTVQKTCDLITEAASTGAEVISFPECWLSGYPAWIWDRPVDPELAARYIRNSLVVESAEMERIRACAAANKIIVALGFSESRHGSLYISQAIIGADGQILTLRSKIKATHMERTIFGDATAECLDSVVDTPLGRIGALSCWEHVQPLLKYHTYSPGGGYSAVFGPDGRKLSTNIPSDKEGIIYADLDIDNILHSKAFLDVVGHYSRPDLLWLGVDTAVKAHVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWS2</accession>
    <name>C7YWS2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_45043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049423.1">
        <property type="nucleotide sequence ID" value="XM_003049377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWS2"/>
    <dbReference type="GeneID" id="9677060"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45043"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45043"/>
    <dbReference type="eggNOG" id="ENOG502SI27">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019838_0_0_1"/>
    <dbReference type="InParanoid" id="C7YWS2"/>
    <dbReference type="OMA" id="QYAFRPF"/>
    <dbReference type="OrthoDB" id="3522351at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF3">
        <property type="entry name" value="SPRAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU43710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="507" mass="55836" checksum="5D93025AA7F1D365" modified="2009-10-13" version="1">MSGQGRESSPQPYGWLSVCLRWPSLLAFSIFNIALIATVIALTIFSSQNDGFVTVPSSNTAKDGEVGDIPDTPWSLGILWTSLPSFVFSLFGAYWAWIAGSLAERQPYVELRKEGGADARVSILLDYRVVASIWRWWGAFRKSHYMVGATTLLSVFLTYLVAPFAARLFVSQVVTVSTSLPIVYNQTYNVDGIDSTVDWRPVFDTVSATRLYGGNKIAWTDDERAFRPFDADSDLATGTSMAANTTAYSAYLNSKTNLKDIKVISCATGYRQVAGTLRVLPSTDAPIIQSFVETGEPNTSRPKLWRVFEQDIFGAVTFNPKMKWSTTDLGTLMLYTAQRAQPSDPLATDVLMDAIQSVFTAIYVNAVSVHGFKTLSEPEKATGSGFVPTTRLFVVTWVAGIIVAFLAITLCTVAVVHFLLRDAPSILSEEPQGLLSMAAILQKSDLLRVASEIRQEVGLEGEIRERAKGQSDVKDRKWRVVKHPETGYWVVRAARNVEMGAAERLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYE1</accession>
    <name>C7YYE1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_62701</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU42991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048704.1">
        <property type="nucleotide sequence ID" value="XM_003048658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYE1"/>
    <dbReference type="FunCoup" id="C7YYE1">
        <property type="interactions" value="1175"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YYE1"/>
    <dbReference type="GeneID" id="9665806"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_62701"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_62701"/>
    <dbReference type="eggNOG" id="KOG1466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_0_1_1"/>
    <dbReference type="InParanoid" id="C7YYE1"/>
    <dbReference type="OMA" id="GDWESCK"/>
    <dbReference type="OrthoDB" id="10249309at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1070">
        <property type="entry name" value="Translation initiation factor eIF-2B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051501">
        <property type="entry name" value="eIF2B_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042528">
        <property type="entry name" value="elF-2B_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU42991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="332" mass="36198" checksum="08DFD8C49E051026" modified="2009-10-13" version="1">MATVEATPAAPAEQQDQPSSTSDFDIVSTYRGLLESDPHLTKPVAAIESLIALLNAHPSTTVFETLEMVKVHSDRLKDSVANPVPLSAGTDLFLQYLVSSLRQQDGSFDAVRQHLLRNGRLFAARANAAREGIADAGFRLVREGQCILTHGASRSVVGILERAVQELGAAKFKVIYVREETRVEESDRVVRELREKGIPVAEIAEASVAYVMGLLRQVNMVIVGAEAVTSNGGIISRMGTLQISKLAAQASVPFYVAVETHKFARKFVMDQRDIGFKQDVLDFSISTKSKQPVDAVDFTPPDLISKLITENGIKLPGYVFEQLLDIYGSLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYR7</accession>
    <name>C7YYR7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_47179</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048952.1">
        <property type="nucleotide sequence ID" value="XM_003048906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYR7"/>
    <dbReference type="FunCoup" id="C7YYR7">
        <property type="interactions" value="610"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YYR7"/>
    <dbReference type="GeneID" id="9665534"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_47179"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_47179"/>
    <dbReference type="eggNOG" id="KOG1607">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028277_4_0_1"/>
    <dbReference type="InParanoid" id="C7YYR7"/>
    <dbReference type="OMA" id="LCRLCML"/>
    <dbReference type="OrthoDB" id="3053196at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF11">
        <property type="entry name" value="CERAMIDE SYNTHASE LAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="12">
        <location>
            <begin position="188"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="13"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="411"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="411"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="433"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU43239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="461" mass="52164" checksum="5F307B72D5039290" modified="2009-10-13" version="1">MSGSEPFPLLNTANDQLHQRRFAPSSSVSNTTATEASISDARRRRKSSALGGDIRGDTGAPALATSRASLDALQSGHKRLSKRRRARGLLARARQTMIKHTFVLPAVLTLCFLAGYAINPTESNPIHHFIFLSYKLPQDDPNEPAQYGKGRWDIAFVAFYTIVLSFTREFIMQELLSPLARWYNLSRGKKARFMEQVYTAIYFGVLGPFGLWVMSHTPVWYFNTRGMYEGFPHQTHLAPVKFYYLFEAAYWAQQAIVLVLGMEKPRKDFKELVGHHIVTLGLIGLSYRFHFTYIGLAVYVTHDISDFFLATSKTLNYIDSPLVGPYFGVFMVAWIYLRHYLNLKIIWSLLTEFETIGPFELNWETQQYKCRLSQVITTALLSSLQALNLFWLFCIVRIAWRFVVQNQLEDDRSEDEGEGEDDEEDVPAPAPKANGHANGHANGHANGHANGNAVSNGNAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYX0</accession>
    <name>C7YYX0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PEBP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_95580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048980.1">
        <property type="nucleotide sequence ID" value="XM_003048934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYX0"/>
    <dbReference type="STRING" id="660122.C7YYX0"/>
    <dbReference type="GeneID" id="9665634"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95580"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95580"/>
    <dbReference type="eggNOG" id="ENOG502SQR1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083918_1_0_1"/>
    <dbReference type="InParanoid" id="C7YYX0"/>
    <dbReference type="OMA" id="YFFELIA"/>
    <dbReference type="OrthoDB" id="10251855at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00457">
        <property type="entry name" value="PEBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049556">
        <property type="entry name" value="PhiB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289:SF1">
        <property type="entry name" value="PEBP (PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU43267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22495" checksum="147F69ECE9A0DAE5" modified="2009-10-13" version="1">MTAYIEVAASWLFKNAKGRDAKAFFTHPAFASHQEPTLSITSPDCGTDGSTLGKEYMHGGEGRFPELTWDSHEDVKEWLLVSEDPDAPLPTPICHGIYLGIPLQKTSVVNSDFKPVDEKSTRLEGGFYYGASRNGMIYIPPRPLLNHGIHRYWFEIIGLSEPLDEKLVTSKPTTEQVAEAINGKVVVWGRWMGQCERRWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYZ4</accession>
    <name>C7YYZ4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mercuric reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_83855</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="5">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048800.1">
        <property type="nucleotide sequence ID" value="XM_003048754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYZ4"/>
    <dbReference type="STRING" id="660122.C7YYZ4"/>
    <dbReference type="GeneID" id="9665647"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83855"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83855"/>
    <dbReference type="eggNOG" id="KOG1335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_1_2_1"/>
    <dbReference type="InParanoid" id="C7YYZ4"/>
    <dbReference type="OMA" id="SHCLMAV"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43014">
        <property type="entry name" value="MERCURIC REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43014:SF2">
        <property type="entry name" value="MERCURIC REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="8">
        <location>
            <begin position="6"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="7">
        <location>
            <begin position="366"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="464"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="186"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="6">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU43087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="51042" checksum="CD47DAAAC9E56B86" modified="2009-10-13" version="1">MSATHYDVLVLGSGQAGNPVAKAFAKAGHKTAVIERAALGGTCVNVGCTPTKTMIASGRAAYMARRDSDYGVRAGNGHVEIDMARVRQRKRAIVEQWNSGSVKGLAAAGVEVIMGDASFVGDRKLKVALQDGGNKEVSASTVFLNVGERSARPEIPGLDDLEPARVLNSTSIMELAEVPRHLVVLGGGYIGLEFGQLFRRLGADVTIVQRARQLVPREDPDVAECLLDILRQDGITIHLSSTIDSISATKNTETPFSVSIKTPTGQTEVSGSHILLAAGRVPNTDGLNLSEVGIKTTAKGHIVVDDRLGTTAPGVYALGDCHGGPAFTHMSYDDFRIIRTNLLSETMSSTTPTMATTQASISRVLTPYCMYTDPQLGHVGLHARDLANSTREIKMAKMPMSYVARALETAEPRGMMKAAVDAKTGEILGFTCLGIEGGEVMSIVQTAMMGGLKWWDLEAAVYAHPTLAESLNNLWGHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZN1</accession>
    <name>C7YZN1_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_101404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048349.1">
        <property type="nucleotide sequence ID" value="XM_003048303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZN1"/>
    <dbReference type="STRING" id="660122.C7YZN1"/>
    <dbReference type="GeneID" id="9667619"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101404"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101404"/>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046009_1_0_1"/>
    <dbReference type="InParanoid" id="C7YZN1"/>
    <dbReference type="OMA" id="TTDGCIY"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051709">
        <property type="entry name" value="Ub-ligase/GTPase-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45622:SF58">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45622">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="215"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="269"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU42636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="328" mass="35008" checksum="CCEE5CE77B8297DB" modified="2009-10-13" version="1">MELPVRIAQAEDAMELYATGFNAWNQLTFDPSTVKDEPDDIFSFTKILGTQRLDRVVSQMCYTAVQREGTWSLAGLSPGTLVSGNADQRYLFDHSSAISADGRVLTVEGLGRPSQAIVEYPALAAWRANRSTHSWPSESGVRQIAAYDGGFVILREDASLSTMGDPRFGDCLGREVDESNPADVPGLVSDLSDIGEPIKMVAAGGYTLAALTEGGGLYLWGMQSPGSQSRHQAFADLSGIPNYVEVDGEKDVQDIALGESHAIALTTDGCVYVVGDNTNGQLGLGSDSKSPVESWLKVPFNSPQGWNIVGVEAGPRSSFIVTAKAKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZT3</accession>
    <name>C7YZT3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_47412</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048376.1">
        <property type="nucleotide sequence ID" value="XM_003048330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZT3"/>
    <dbReference type="STRING" id="660122.C7YZT3"/>
    <dbReference type="GeneID" id="9667644"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_47412"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_47412"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_1_1"/>
    <dbReference type="InParanoid" id="C7YZT3"/>
    <dbReference type="OMA" id="HVMFGGE"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="31"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU42663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="494" mass="52402" checksum="94E2C49087266E95" modified="2009-10-13" version="1">MAETTITGAGGRKITLPTGLFIDNKFSPAAENKTIAIENPSTGDTIANLSAAQAADVDRAVASSKAAFKNTWRLTGPAKRRALLNKLGDLIEQNAEEFASIEAVDAGMLYTMSMGLSVTQAVECCRYYAGWADKLDGQAIENDQSLSYTRREPIGVCAAIVPWNSPLMITFWKLGPAIAAGNTLVIKTPELAPLYGQKLAQLVTEAGFPPGVINILCGVGSVAGQALADHADVRKISFTGSEGVGRGILASAARSNLKRVSLELGGKGPAIIFKDADFENALMWAGAGITVHNGQICVAGSRIYVQEEIYDKFIAEFSKRTKDAVAGDPLLAETVKGPVISEAQKNRILGFITKAKEEGTKLLHGGEKELSGKGHYIPNTAFVDVSPDATIIKQEVFGPVASIAKFKTEEEVIALANGTDYGLAASIFTNDIARAVRVSEQVEVGIVTINTWGSIHANTPFGGVKQSGFGREMGQDALNDWTQVKCVKLSVPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZT5</accession>
    <name>C7YZT5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histidine kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_105157</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048567.1">
        <property type="nucleotide sequence ID" value="XM_003048521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZT5"/>
    <dbReference type="STRING" id="660122.C7YZT5"/>
    <dbReference type="GeneID" id="9667455"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_105157"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_105157"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002763_0_0_1"/>
    <dbReference type="InParanoid" id="C7YZT5"/>
    <dbReference type="OMA" id="EVIPQPC"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000023">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000083">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative (AFU_orthologue AFUA_4G00660)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF11">
        <property type="entry name" value="HISTIDINE KINASE_RESPONSE REGULATOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="537"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="1028"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="335"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="425"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="975"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="1083"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU42854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1152" mass="126010" checksum="E262833797703684" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z023</accession>
    <name>C7Z023_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_95860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048608.1">
        <property type="nucleotide sequence ID" value="XM_003048562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z023"/>
    <dbReference type="GeneID" id="9667502"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95860"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95860"/>
    <dbReference type="eggNOG" id="ENOG502S1UN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017096_2_1_1"/>
    <dbReference type="InParanoid" id="C7Z023"/>
    <dbReference type="OMA" id="GRIYWFK"/>
    <dbReference type="OrthoDB" id="14339at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332:SF1">
        <property type="entry name" value="ELMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="422" mass="45795" checksum="5E4E3302446A20B0" modified="2009-10-13" version="1">MPPKTPNSTGTPIFSTSIFSSSSNTAASRPTTRDGHGVDPLNTNHPNLLIKDRKPSFSRKSSLSGSRRRGSSFGNGPNAYVTDATAPPALPEYALAAAAKISPRPDLAEGHHLPQAPDLGIQMLNRTATGSTIHLGGGMTSHGTSNGAPGTTGVWQQSEVSIMHQHVTELANKRISTLDYLRKAHEGRVHWFKTYLFERPDLNRMPSFDARKLGRKATNHLLLGLSLPTVVDLYSSTPIEFLRSLNTLLSEYDSFQQLHGDSSTAASLTRARLPSMFRRPGGKSRRSTSAADMHPMVDEMAPVPAAGGPAPAVMNFAASETDLLPGEEYTHLLTPSLPFDPDYFETFATLCDVLIDCYTRFLALVPSPRECSAPVAELFTKADSRVRKIIVQGIVREFEDQSRHHIKTEVASIGKVVLGGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0A3</accession>
    <name>C7Z0A3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_47676</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048468.1">
        <property type="nucleotide sequence ID" value="XM_003048422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0A3"/>
    <dbReference type="STRING" id="660122.C7Z0A3"/>
    <dbReference type="GeneID" id="9667545"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_47676"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_47676"/>
    <dbReference type="eggNOG" id="KOG0159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_2_1"/>
    <dbReference type="InParanoid" id="C7Z0A3"/>
    <dbReference type="OMA" id="ECMDHMA"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF164">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU42755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="49310" checksum="3C4709EA422A5F67" modified="2009-10-13" version="1">MFLLSIPALSIAIAVCALFYVWKCVSSPLWAAPGPFLSRFTPFMLRWNEFNANRTLYIHSLHLKYGPIVRIAPNEMSFSSYEAVKEIYGSKGSGYDKSTFYDLFTVFGRRTLFSTLDKTAHAKRKRLLADRYANSNVLKPASLNGIENRAREFARQCGDSTGSSRLFMLYTPTLYKYSSKILDCFFEPRATPLADNFVTKRSKLDDPEEFTLLSRLRSKLGDELAEGDIASECLDHMVAGIDTTGDVLCFLIWELSQPRSAQFQDELRRELKGNPDMAFDKLPVLDSIVQEGLRCFPAIPMSLPRVVPKDGRVIDDIFVPEDTIVSSQAYSVQRHHAHVFPEPDRFNPHRWMSNENDAEMRRHIFAFSYGGRGCIGKHLAYAEMKLLLREVYSQYQTVPDPSMTEESMRAHDQIISARPFGQKCLLRFVPTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1R1</accession>
    <name>C7Z1R1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_72448</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU42044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047757.1">
        <property type="nucleotide sequence ID" value="XM_003047711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1R1"/>
    <dbReference type="STRING" id="660122.C7Z1R1"/>
    <dbReference type="GeneID" id="9671542"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_72448"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_72448"/>
    <dbReference type="eggNOG" id="KOG0586">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019271_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z1R1"/>
    <dbReference type="OMA" id="IARCEWA"/>
    <dbReference type="OrthoDB" id="410920at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000640">
        <property type="entry name" value="Serine/threonine-protein kinase PRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="395"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="90"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="277"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="348"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU42044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="736" mass="80360" checksum="16A80D192A349BC1" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z2D4</accession>
    <name>C7Z2D4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_86113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU42151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047864.1">
        <property type="nucleotide sequence ID" value="XM_003047818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z2D4"/>
    <dbReference type="GeneID" id="9671483"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86113"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86113"/>
    <dbReference type="HOGENOM" id="CLU_750261_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z2D4"/>
    <dbReference type="OrthoDB" id="4994634at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029167">
        <property type="entry name" value="Mug117"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18647">
        <property type="entry name" value="Fungal_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15474">
        <property type="entry name" value="MU117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU42151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="369" mass="40880" checksum="92B1EBB9A00105E8" modified="2009-10-13" version="1">MELIGGNTIVVLEASKLFELGAHVGRHDLKVILVELRVENCVPLGTGQEPQSEDRDVEEELYIPLASLEPHPDSDRWMIDGDTSGYKPPEPDFPACFGLQTNRYMNRGVLAGNIEHFCEAAQARARPDSGSKFISTVYNGGTPNEVMLIIDYETPDIDYEIGKEDCVFYLKEIVLDRCDSSSKDNPGNWKAGGVAHKDKIRCKFNYGGDGDNREWTAEMNGGSDVEDKCISEAIEKAGGPKVAYEKAAPPPPPPKPFEPKYDCQGSGLCGGPLLQVKHCDYAVNRLRRNQADPTWYGTQEGRLTRNCWAKSDGIGSGVFLEGSGCELIGDDIWEHYQKIRSLWKKCGKVEYKAGCFVKIDYVTGCNNHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z2D9</accession>
    <name>C7Z2D9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_72983</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047177.1">
        <property type="nucleotide sequence ID" value="XM_003047131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z2D9"/>
    <dbReference type="FunCoup" id="C7Z2D9">
        <property type="interactions" value="118"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z2D9"/>
    <dbReference type="GeneID" id="9676043"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_72983"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_72983"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_1_1"/>
    <dbReference type="InParanoid" id="C7Z2D9"/>
    <dbReference type="OMA" id="PRIHLGV"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="31"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU41464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="289" mass="31616" checksum="C0FE691B33130913" modified="2009-10-13" version="1">MASSTPSLLASKATLANGITIPRVQLGLYMMSTKEATEAVRLGLLSGYRGFDCAQMYRNERQAGKAISDFLGSSENTTGLKREDIFYTSKLASCDESYDAVRRSIKKSVDESGLGYIDLFLLHSPYGGKQARLTSWKALEDAIDAGEIRSGGVSNYGSAHIEELIASNPRIPPVINQIEVHPFNTQTDIRATCAKHNITIEAYAPLARAMRMSDPTIMGLAKKYSVTVAQIFVKWGLQHGFVTLPKSTKQARMLENASVDGFEISESDMAILDALDEHLVTDWDPTDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z360</accession>
    <name>C7Z360_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_102175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102175"/>
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            <begin position="555"/>
            <end position="824"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="26"/>
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    </feature>
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            <begin position="42"/>
            <end position="71"/>
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</entry>
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        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
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                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
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                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
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                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
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                <person name="Salamov A."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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                <person name="Nelson D.R."/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
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        <name evidence="2" type="ORF">NECHADRAFT_76481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046614.1">
        <property type="nucleotide sequence ID" value="XM_003046568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4D2"/>
    <dbReference type="STRING" id="660122.C7Z4D2"/>
    <dbReference type="GeneID" id="9669026"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76481"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76481"/>
    <dbReference type="eggNOG" id="ENOG502RJ9K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_415654_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z4D2"/>
    <dbReference type="OrthoDB" id="5062424at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU40901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="660" mass="74522" checksum="8E236ED6696E3821" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4W0</accession>
    <name>C7Z4W0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_76655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046705.1">
        <property type="nucleotide sequence ID" value="XM_003046659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4W0"/>
    <dbReference type="GeneID" id="9678510"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76655"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76655"/>
    <dbReference type="HOGENOM" id="CLU_790092_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z4W0"/>
    <dbReference type="OrthoDB" id="5101024at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU40992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="351" mass="38274" checksum="59D64936B043EA60" modified="2009-10-13" version="1">MSHTNASSRLAQSSREGLQPSSPDPSQTAAAPEFGQLIRLLEDKLAQGSDADISLSMDDTHELVRALRFSKDANDRLQVVEQELVEAKQRAGESPFLGKFGDYARHVWNDIHSASDDGELPKKVTDAATLIEDPTGKKGTIFRKRAETLRQPLSEQAARCAAFAYSVRCQLFHSEEVYNATKETIGPRADADLETLATDLPNSRSDQLGYWQEIINYVKCTRGPQGSKSGKTSSDKVSIPRLSGLTSIQSAQLLAILAADGTLPRSATPFLLEHGVFGASPVVPLVSRSNRGQSAPPLAIRKRKEIAGEDVPLYEPFAKRQELGLPPGEKANDNDMKASERQNIDTAHMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4Z3</accession>
    <name>C7Z4Z3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane BAX inhibitor motif-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_58420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU41010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046723.1">
        <property type="nucleotide sequence ID" value="XM_003046677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4Z3"/>
    <dbReference type="FunCoup" id="C7Z4Z3">
        <property type="interactions" value="643"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z4Z3"/>
    <dbReference type="GeneID" id="9678250"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_58420"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_58420"/>
    <dbReference type="eggNOG" id="KOG2322">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058671_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z4Z3"/>
    <dbReference type="OMA" id="FGVMSLY"/>
    <dbReference type="OrthoDB" id="7933078at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd10429">
        <property type="entry name" value="GAAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF50">
        <property type="entry name" value="PROTEIN LIFEGUARD 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU41010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="30505" checksum="5BC8BA7DC40343AB" modified="2009-10-13" version="1">MASSTKYQPAPQSDPDDYTHAPPAYAEGSASRDETQGLFGAPRDSEDNLPDDFKFGGSVAEATVDIRNQFVRKVYTILTVQLLATAGVSSLTFFSAGYKEWIQGHPGVVWASLFGAMIFMGLTYWKRKSYPTNLLFLSLFTLAEAYTISVIVSFYKTSIVLNAVVLTAGIFVFLTLFACQTKYDFTSWMPYLFGALWGLVIFGFMAMFFPYSSTGELIYGGLAALIFSGYILVDTQLVLRHHHVEEEIAAAISLYLDIINLFLAILRILNSQSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z522</accession>
    <name>C7Z522_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ABC transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_91240</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU41025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046738.1">
        <property type="nucleotide sequence ID" value="XM_003046692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z522"/>
    <dbReference type="GeneID" id="9678264"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_91240"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_91240"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_17_8_1"/>
    <dbReference type="InParanoid" id="C7Z522"/>
    <dbReference type="OMA" id="ILICIMP"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000057">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="575"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="623"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="696"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="722"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="801"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="837"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="36"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="363"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="579"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="902"/>
            <end position="1153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU41025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1157" mass="126117" checksum="800A94412693627D" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z5P1</accession>
    <name>C7Z5P1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">NECHADRAFT_65991</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046272.1">
        <property type="nucleotide sequence ID" value="XM_003046226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z5P1"/>
    <dbReference type="FunCoup" id="C7Z5P1">
        <property type="interactions" value="140"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z5P1"/>
    <dbReference type="GeneID" id="9678109"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_65991"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_65991"/>
    <dbReference type="eggNOG" id="KOG1027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004875_2_0_1"/>
    <dbReference type="InParanoid" id="C7Z5P1"/>
    <dbReference type="OMA" id="QCYEKDY"/>
    <dbReference type="OrthoDB" id="63989at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09769">
        <property type="entry name" value="Luminal_IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10422">
        <property type="entry name" value="RNase_Ire1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13982">
        <property type="entry name" value="STKc_IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative Serine/threonine-protein kinase/endoribonuclease IRE1"/>
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        <property type="entry name" value="KEN domain"/>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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        <property type="entry name" value="IRE1/2-like"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
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        <property type="entry name" value="S_TKc"/>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
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    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
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    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 19" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="8 21" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988853" description="non-specific serine/threonine protein kinase" evidence="21">
        <location>
            <begin position="36"/>
            <end position="1217"/>
        </location>
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    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="784"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="domain" description="KEN" evidence="23">
        <location>
            <begin position="1082"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="515"/>
            <end position="541"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="612"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="89"/>
            <end position="98"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="619"/>
            <end position="634"/>
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    </feature>
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        <location>
            <begin position="685"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="696"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="706"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="744"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="812"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51392"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEU40559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1217" mass="135568" checksum="A3876E1A7E70609C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z5V3</accession>
    <name>C7Z5V3_FUSV7</name>
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        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_75881</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
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        </reaction>
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        <property type="protein sequence ID" value="EEU40017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003045684.1"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="C7Z5V3"/>
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        <property type="component" value="Chromosome 2"/>
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        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="BRcat_RBR"/>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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        <property type="entry name" value="Znf_RING_CS"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IBR"/>
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        <property type="entry name" value="RING/U-box"/>
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        <property type="entry name" value="ZF_RING_1"/>
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    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="156"/>
            <end position="345"/>
        </location>
    </feature>
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        <location>
            <begin position="98"/>
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        </location>
    </feature>
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        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS51873"/>
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        <source>
            <dbReference type="EMBL" id="EEU40017.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="430" mass="48679" checksum="5958DDDD3307EA30" modified="2009-10-13" version="1">MECCGLDTESLMLVIQLQRQDLDECEHSKKGKHREDEIIDSEVALKLCRQELEEVAMLISDQALCISIAKAVDSDALLIAEAKAAEEQAASDRAFALRLSGNPQATPATDTTKTNERKRTADHLDDASIERFKLMNRFEPDHAESSSSAAYREPPETRECIACTDSFPTSALARSPCSHEYCRGCLVGLVQSSLRDESLFPPRCCTQPIPIEPGPWFSPALVGEFRAKQLEHDTPDRTYCSQPTCSTFVPPAFIAKDVARCPKCSQRTCVHCKGPFHHGVCPNDTVSQQVLELATQNGWQQCKVCKRVVELEQGCNHITCKCKAEFCYVCGERWKTCACPHWNEEHLYNRANAIVARANTAAQILENVRQRLVEQERLNLLDNHECIHERWRGRRGPAECEECLDIMPVFIYECRQCHIMACRRCRYNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z691</accession>
    <name>C7Z691_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_33588</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045798.1">
        <property type="nucleotide sequence ID" value="XM_003045752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z691"/>
    <dbReference type="STRING" id="660122.C7Z691"/>
    <dbReference type="GeneID" id="9668557"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_33588"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_33588"/>
    <dbReference type="eggNOG" id="ENOG502SJWB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026304_0_1_1"/>
    <dbReference type="InParanoid" id="C7Z691"/>
    <dbReference type="OMA" id="VYATVGH"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="44"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU40085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="396" mass="44743" checksum="2A20749EA3AEB279" modified="2009-10-13" version="1">MELSLLDESKRLLQADLENICLENIQTCILIANLCASHGNPSSEALYFRIGNSMAQIMRLNSPTSTGSIVEREIERRVWWSLFMADRWSSAGIGLPRQIKDLGGNIDLPMDESVFHSLPQHLTRHEGTWKPGLWAHMISLVQHFGPIQDLNRQSAQGCFDGWELDRTAAELSQKLDLWEKMLPTDAKETDQNFRLHQTKGTGGPFVGLHLGYHHYSTLLYFRYLEARNSVTEFGQNCVSRCKHHASAYSALLRTARESEGCEAVYPTVGHMAVVSSSVLLHTLLFGDENELANARRDLNSNFAALMELKQYWANTTSMISRLVTFQNVCLLSAEYTHRLDGWMVRFLIEHSLPLADKTLQTVPSGIEMNTDSLSIRAQELQQQGRYTNFELSGPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6Q5</accession>
    <name>C7Z6Q5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoserine phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_90803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045886.1">
        <property type="nucleotide sequence ID" value="XM_003045840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6Q5"/>
    <dbReference type="FunCoup" id="C7Z6Q5">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z6Q5"/>
    <dbReference type="GeneID" id="9668082"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90803"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90803"/>
    <dbReference type="eggNOG" id="ENOG502QRU0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058495_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z6Q5"/>
    <dbReference type="OMA" id="VPFHEFD"/>
    <dbReference type="OrthoDB" id="10014216at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050849">
        <property type="entry name" value="HAD-like_hydrolase_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006384">
        <property type="entry name" value="HAD_hydro_PyrdxlP_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01489">
        <property type="entry name" value="DKMTPPase-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181:SF2">
        <property type="entry name" value="PHOSPHORIC MONOESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181">
        <property type="entry name" value="UPF0655 PROTEIN YCR015C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12710">
        <property type="entry name" value="HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU40173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="28275" checksum="B9B55C48BA61CF2A" modified="2009-10-13" version="1">MASSDTPALKNNPKFIFFTDFDGTVTTADSNDYMTDNLGFGVERRRQLNKDVLYGRMHFRDSFVEMLDSVKTPFDECIKILLHNIKLDPGFKEFYDWAKVNNVPIVILSGGMQPIIRALLDVLLGPGWDIQIVSNDVRAREGKDLNDEGGWRIEFHDDSIHGHDKSLEIRKYSSLPNRPTMFYAGDGVSDLSAAKETDLLFAKADMDLVTWCENENVPFVTFRDWSSITQTVKEIVAGDLSVKDAARGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6W7</accession>
    <name>C7Z6W7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450 monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_90852</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045913.1">
        <property type="nucleotide sequence ID" value="XM_003045867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6W7"/>
    <dbReference type="STRING" id="660122.C7Z6W7"/>
    <dbReference type="GeneID" id="9668117"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90852"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90852"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_11_1"/>
    <dbReference type="InParanoid" id="C7Z6W7"/>
    <dbReference type="OMA" id="QNMQRVI"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU40200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="52650" checksum="0FF7E02D08619944" modified="2009-10-13" version="1">MLAIGLWLLAALPLLALLKIIYNVLLHPLRHHPGPKLWASTRIPWCWNQYQGKLNHRLVELHHQYGPAVRVAPDEVSYTSDTAWKTIYGHRSVEMTKDPIFSLVTPTGVPNIVTADRVNHSRHRRLLSHAFSEKALREQEDILVQYCTKLLDQLQARCSDGPLDLAKWFPLTTFDLIGSLAFGQDFSCIDTGEPHPFVACIKGVSRELVMSQMAQYYGFGSLRYFLFLRGSANSRGPTDDRKDFWHHVLAAEDQGKGLTPDEMVVDAFSIAIAGSDGTATALAGTTYLLLTHRDVYQQLQGFIRQEFEAEEDITTLALSNERVPLLGAVIQESIRLFPPVAATLPRVVPPSGETIDGLFVPEGTIVGVNQLAAYHSEKNFNQASEFLPERWLSEQGDCRAVFQPFSFGPRNCLGKNLAKAELRLILARMLWRFDMELLPESQGWMDGQKIYGFWIKPPLMVKLSPRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z765</accession>
    <name>C7Z765_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="7">1.1.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_32312</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2</text>
            <dbReference type="Rhea" id="RHEA:21252"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:16782"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.1.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the L2HGDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.2" evidence="7"/>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046531.1">
        <property type="nucleotide sequence ID" value="XM_003046485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z765"/>
    <dbReference type="STRING" id="660122.C7Z765"/>
    <dbReference type="GeneID" id="9668871"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_32312"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_32312"/>
    <dbReference type="eggNOG" id="KOG2665">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024775_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z765"/>
    <dbReference type="OMA" id="GVHFTRM"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104:SF4">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="9">
        <location>
            <begin position="34"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU40818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="413" mass="44394" checksum="1E9CF83C7705EBDA" modified="2009-10-13" version="1">MLRPLVRSVTSDWRGIQKLNFSSTSVARADFTHAVVGGGVVGLAIARKLAQRGDNSTVLIERHNAVGTETSSRNSEVIHAGIYYGPSSLKAKLCIRGKNLLYELCEKHDVGHRRTGKWIVAQNEAQREALEKIHALCENQLGVPTRWVTGEEVKRDGEGVKAACALDSPTTGIVDSHGLMMCLLGLFEEAGGVAALNSPVVGIKPLGAQPGSEGWEIEVKDASTGETSSITAETLINAAGLGAATIHNMIVPEDRQQNLYYAKGNYFSYSASHPRISRLIYPAPEPGAAGLGTHLTLDLAGRVRFGPDVEWVDRPDDLAVNATRLPQAIVEIQKYLPGVKAEDLVADYAGIRPKLADQGAVLKGKGFHDFVIRREEGYEGWVNLLGIESPGLTSSLAIAEEVEGLVYGKEQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z854</accession>
    <name>C7Z854_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_100312</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045523.1">
        <property type="nucleotide sequence ID" value="XM_003045477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z854"/>
    <dbReference type="STRING" id="660122.C7Z854"/>
    <dbReference type="GeneID" id="9672551"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100312"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100312"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_1_1"/>
    <dbReference type="InParanoid" id="C7Z854"/>
    <dbReference type="OMA" id="GRKWDGT"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="16"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU39810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="351" mass="36800" checksum="4BCD065A82CCBC0E" modified="2009-10-13" version="1">MTVTQEPLHKAAVVVRSDSSFRFEVRSVPIPKPKPWEVLVKLSATGVCGTDMGLAAGHLGPCRDILGHEGVGRVVRIGDGVDPSIVKTGDRVGIAWVRDVCGKCSCCREPGGETRCRELQNSGRNWDGTFAEHCVVPSRYVLVLPEDPALSDELIAPVLCGGVTAYKAVKTCGAVPGEWVAVVGAAGGVGGLAVQYAKAMGYQVAAVDVGPSQEACLKAGADAYFDATDPDIVSALKKITPDEVGAKAVIVTANSGKAYQTALDLIAVFGSLVCVGIPPPDQLLTLHPITIMDRGIRIIGTLVGTRTDTLEALEFVRRGTVKPVVNTVGFDQLNDVTSKFGSTTGKFVAQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8N2</accession>
    <name>C7Z8N2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_44215</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU38984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044697.1">
        <property type="nucleotide sequence ID" value="XM_003044651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8N2"/>
    <dbReference type="FunCoup" id="C7Z8N2">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z8N2"/>
    <dbReference type="GeneID" id="9673193"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_44215"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_44215"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004760_1_1_1"/>
    <dbReference type="InParanoid" id="C7Z8N2"/>
    <dbReference type="OMA" id="TTMRETE"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902404">
        <property type="term" value="P:mitotic actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF38">
        <property type="entry name" value="CHITIN SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="745"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="788"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="819"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="863"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="988"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1022"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="13">
        <location>
            <begin position="327"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="49"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU38984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1085" mass="122726" checksum="A674DBD3FD370C78" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8S5</accession>
    <name>C7Z8S5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">P-type Na(+) transporter</fullName>
            <ecNumber evidence="19">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">NECHADRAFT_43112</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="19"/>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045152.1">
        <property type="nucleotide sequence ID" value="XM_003045106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8S5"/>
    <dbReference type="FunCoup" id="C7Z8S5">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="GeneID" id="9673645"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_43112"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_43112"/>
    <dbReference type="eggNOG" id="KOG0202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_3_3_1"/>
    <dbReference type="InParanoid" id="C7Z8S5"/>
    <dbReference type="OMA" id="ICNCMTL"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008554">
        <property type="term" value="F:P-type sodium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000015">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000039">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000047">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006414">
        <property type="entry name" value="P-type_ATPase_IID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01523">
        <property type="entry name" value="ATPase-IID_K-Na"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="17" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="791"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="818"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="869"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="967"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1000"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="23">
        <location>
            <begin position="16"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EEU39439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1067" mass="116849" checksum="8C21B15845B81BEF" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8U7</accession>
    <name>C7Z8U7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycoside hydrolase family 5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_70188</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044747.1">
        <property type="nucleotide sequence ID" value="XM_003044701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8U7"/>
    <dbReference type="GeneID" id="9673657"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_70188"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_70188"/>
    <dbReference type="eggNOG" id="ENOG502QPU8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009024_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z8U7"/>
    <dbReference type="OMA" id="NEFIPPW"/>
    <dbReference type="OrthoDB" id="9971853at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050295">
        <property type="term" value="F:steryl-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904462">
        <property type="term" value="P:ergosteryl 3-beta-D-glucoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF5">
        <property type="entry name" value="ERGOSTERYL-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="782"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="5">
        <location>
            <begin position="644"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU39034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="806" mass="91871" checksum="5A43BE31AB0DA348" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8V1</accession>
    <name>C7Z8V1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_81639</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044749.1">
        <property type="nucleotide sequence ID" value="XM_003044703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8V1"/>
    <dbReference type="STRING" id="660122.C7Z8V1"/>
    <dbReference type="GeneID" id="9673325"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_81639"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_81639"/>
    <dbReference type="eggNOG" id="KOG0022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_2_1"/>
    <dbReference type="InParanoid" id="C7Z8V1"/>
    <dbReference type="OMA" id="LRIQLMA"/>
    <dbReference type="OrthoDB" id="256333at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08254">
        <property type="entry name" value="hydroxyacyl_CoA_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="9"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU39036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="325" mass="33757" checksum="C14EE96139185882" modified="2009-10-13" version="1">MKAFQYENSQKGLELRDIPKSEPGNGRVQLQVKAAGMCHSDCHIVSGSSDAWLTKKPITLGHEVAGIITEIGPGVTGFNLGDRVAVSQVCHPVEERDWSLGIGLGFDGGYAQYAVAPARRLMHIPGGVTFAQAAVATDALSTSYHAVVAEAAAKPGMIIGVVGLGGLGMSGLAFGALQGAAMYGFDIDKDKFEEATRLGASGCFESLDLASDVAFDAIVDFAGTGNTTQNALKAVKEGGKVVLVGLAAKKVEVPTELLVLRTVTLVGSLGASVDDLAQVLKLLKEGLIDPMLVEVPFSEIPASIDALAKGGVKGRRWVDPSKVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8Y9</accession>
    <name>C7Z8Y9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_81676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045179.1">
        <property type="nucleotide sequence ID" value="XM_003045133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8Y9"/>
    <dbReference type="GeneID" id="9673682"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_81676"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_81676"/>
    <dbReference type="HOGENOM" id="CLU_1611234_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z8Y9"/>
    <dbReference type="OrthoDB" id="2822601at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU39466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="165" mass="18766" checksum="9E775AAC4A0A4D08" modified="2009-10-13" version="1">MANRCYFIVTPDPNWSHAFLWVRLTGGDEDDANGNPELYFHIKFGDGESSYTTLNPNFKKVENVLSPNPTRTLQIPGPNGLYYVTRKIGKSLELDYMIKLTLQTDSTEWRRVTLKAGANFAGLRQVLIDMLTRFPNYDWQTGAGSTRMAFEQNCTSWLAANCNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9G5</accession>
    <name>C7Z9G5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_19018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044805.1">
        <property type="nucleotide sequence ID" value="XM_003044759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9G5"/>
    <dbReference type="FunCoup" id="C7Z9G5">
        <property type="interactions" value="1037"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z9G5"/>
    <dbReference type="GeneID" id="9673790"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_19018"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_19018"/>
    <dbReference type="eggNOG" id="KOG0864">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067861_0_1_1"/>
    <dbReference type="InParanoid" id="C7Z9G5"/>
    <dbReference type="OMA" id="NFKDSFM"/>
    <dbReference type="OrthoDB" id="2357150at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13179">
        <property type="entry name" value="RanBD_RanBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000254">
        <property type="entry name" value="Ran-specific GTPase-activating protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045256">
        <property type="entry name" value="RanBP1_RanBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF87">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE RANBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="2">
        <location>
            <begin position="75"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU39092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="220" mass="24586" checksum="C61828899B6A212A" modified="2009-10-13" version="1" fragment="single">ETKPEETKPEVAPAAEAEGSADKPVTSSSVFSMFGGGAKKEKKDEDEDRGDNSGSAKAQREAKGDEDAPESEDVHFEPVIKLTEKVETKTNEEAEEQTFKMRAKLFKFVKESSEWKERGTGDVRLLKHKENGKTRLVMRRDKTLKVCANHYIVPEMKLSPNVGSDRSWVWNAAADVSEGEPEAVTLAIRFANSENANLFKDSFMKAQKENEEIFNKAQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAX9</accession>
    <name>C7ZAX9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_95141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044514.1">
        <property type="nucleotide sequence ID" value="XM_003044468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAX9"/>
    <dbReference type="GeneID" id="9670708"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95141"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95141"/>
    <dbReference type="eggNOG" id="ENOG502S3K0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033907_2_0_1"/>
    <dbReference type="InParanoid" id="C7ZAX9"/>
    <dbReference type="OMA" id="YFFYDAF"/>
    <dbReference type="OrthoDB" id="3650366at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053226">
        <property type="entry name" value="Pyrrolopyrazine_biosynth_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419:SF1">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU38801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="38485" checksum="1AE96AFB9F508845" modified="2009-10-13" version="1">MTQGSTSQERRLYWLLTSPRTASNLLVKVLNLDEQGVRPAREGGYFFLPSIGTRLNLLQKPMEDWTEEECKDLEDRQKECLSRLEEYIAAADQEGQLVYVKEHAIMLTSAFYDSQFTYGTINVPGEPKTFVTTNAPNPTRSSLNLTFLPDEFLKIWSPTFLIRHPAMQLPSLFRTCLTKMEMDGFSRWQKEPLDIEVTMKWFRAMYDFYVKHFGEDSQWPIVLDADDIMTSPHLVSKYAALAGLDQDKLRFSWDKANKEKLDTLSSMEQRMLSTINASSKIDSSKVAGNINIDDEAAKWRSEFGEEGGRKLEQWVRDAMPDYNFLHSKRLRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAZ5</accession>
    <name>C7ZAZ5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_95150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044392.1">
        <property type="nucleotide sequence ID" value="XM_003044346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAZ5"/>
    <dbReference type="STRING" id="660122.C7ZAZ5"/>
    <dbReference type="GeneID" id="9670814"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95150"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95150"/>
    <dbReference type="eggNOG" id="ENOG502SJHH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037349_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZAZ5"/>
    <dbReference type="OMA" id="GDCPHPS"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF8">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU38679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="555" mass="62151" checksum="50887A0FD08B291C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBC7</accession>
    <name>C7ZBC7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">OPT superfamily oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_95155</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044532.1">
        <property type="nucleotide sequence ID" value="XM_003044486.1"/>
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    <dbReference type="KEGG" id="nhe:NECHADRAFT_95155"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95155"/>
    <dbReference type="eggNOG" id="KOG2262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004965_3_0_1"/>
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    <dbReference type="OMA" id="QNLHFDR"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
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        <property type="component" value="Chromosome 7"/>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:protein transport"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Oligpept_transpt"/>
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        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="452"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="604"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="650"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="683"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU38819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="730" mass="81733" checksum="0AAC7E1073FF26F9" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBN7</accession>
    <name>C7ZBN7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_25351</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698915">
        <property type="protein sequence ID" value="EEU38598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003044265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBN7"/>
    <dbReference type="GeneID" id="9670634"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_25351"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_25351"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="2988756at2759"/>
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        <property type="component" value="Chromosome 14"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
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        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="30"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU38598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="288" mass="32240" checksum="8D78CA342D308110" modified="2009-10-13" version="1" fragment="single">MSATNAYAVEVFTLLGLGTLIIGVRTYGRTQLAGIRKLALDDYLMLFVTIPYIAEIVLAYTVKHRFHGLANNAMTDDERVSLPSTSEEYEWRQALVKGSKIQVAGWAVYATVLWLIKSSMCAFYNRLTNGLPEYRRRIRWGFILIAATYLVVLGVILLGCQPLYRLWQIYPDPGNFCQPAISKLLVFLVLTLNVITDVYLLILPIPALRKAQVTRIKRAVLVLLFSGGVFVMAAGILRCVLIIKNPTKGPQQAASWAVRESFVAIVTSSIPVIWGWMKQRLKPLFSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDE4</accession>
    <name>C7ZDE4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C6 zinc finger protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_88172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043599.1">
        <property type="nucleotide sequence ID" value="XM_003043553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZDE4"/>
    <dbReference type="GeneID" id="9669625"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88172"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88172"/>
    <dbReference type="eggNOG" id="ENOG502SJ6A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024934_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZDE4"/>
    <dbReference type="OMA" id="HHTHLGD"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF7">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="32243" checksum="81FC9BD47CDCB4CA" modified="2009-10-13" version="1">MLDLQPMHNFTNSTYATFSRHQVIRSFWKGPLVAMALQCDYLMRALLATSALHMTHNMPEEKEFYVSTALTYHRAASREALTLLALSSHRENAKGNPFFADGDFPEWPFLIQGTKSLLVLPDINLREGRLSPLLAARVQSHQYKTFKAGSNDASSSMMKALDDLGDLIGLNTKDEDTVKIYKRTISYLRDLSKMLDAAEVEISEVFGWIYAMADDFLPLLRASKYETVAIFAFVCVFLKRLEMHWWMGNWGEQLLRKAEGVLDNEHKLWIAWPMEELGMHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDE8</accession>
    <name>C7ZDE8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_54685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043602.1">
        <property type="nucleotide sequence ID" value="XM_003043556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZDE8"/>
    <dbReference type="STRING" id="660122.C7ZDE8"/>
    <dbReference type="GeneID" id="9669628"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_54685"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_54685"/>
    <dbReference type="eggNOG" id="ENOG502SJA0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006866_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZDE8"/>
    <dbReference type="OMA" id="TESIWAD"/>
    <dbReference type="OrthoDB" id="5400409at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="490"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="695" mass="78662" checksum="F70E5F6E7FD639BB" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDH8</accession>
    <name>C7ZDH8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3669 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_88204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043497.1">
        <property type="nucleotide sequence ID" value="XM_003043451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZDH8"/>
    <dbReference type="GeneID" id="9669447"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88204"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88204"/>
    <dbReference type="HOGENOM" id="CLU_797140_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZDH8"/>
    <dbReference type="OrthoDB" id="2993351at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40780">
        <property type="entry name" value="DUF3669 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40780:SF2">
        <property type="entry name" value="DUF3669 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU37784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="39364" checksum="32B43AEBFAA663D9" modified="2009-10-13" version="1">MSDASEPPRHYLESTLDDLPPSYVLLNALKTGVSIFPDSHNLNAPGGTDKLIELDYGSRSCVVHKPGQPFVVKKLHPRFGFNNHQLAKEAATEAMQTNEVFEYFEKWQSKSGVSIRAPGNAKCIENWQEFWNAHKDSLPSPWNFPTPALKMDMIYPLPKAVGRALIQQFYPKREGSTMDPYVVEEILNQYGNQHCLVQPCLGLDVRPRKPGDFSLNNFELSLADMQSIGINVADLAAAMGEAFGLLHYSRRLFCDGIKFAFGTSLENKQHRHSSHIVNLDETDEDGLVMADTMLEPDIRKFIPSPLKSPALYNVFKDAYIGQAILKEIKLLPYMVMKNYERRVAREFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDW2</accession>
    <name>C7ZDW2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxidase FUB9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Fusaric acid biosynthesis protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_88152</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043589.1">
        <property type="nucleotide sequence ID" value="XM_003043543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZDW2"/>
    <dbReference type="STRING" id="660122.C7ZDW2"/>
    <dbReference type="GeneID" id="9669423"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88152"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88152"/>
    <dbReference type="eggNOG" id="KOG0538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020639_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZDW2"/>
    <dbReference type="OMA" id="SHITTPW"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000056">
        <property type="entry name" value="hydroxyacid oxidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF149">
        <property type="entry name" value="2-HYDROXYACID OXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="9">
        <location>
            <begin position="7"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="86"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="290"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="313"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00083297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU37876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="377" mass="41753" checksum="CFEC9D80FBE4A68C" modified="2009-10-13" version="1">MANRGRSYDEQVHSLRDLQRLGSEKLVKSTREYYNEGAMDLITLHENESAYDRYRIRPRVLRDISVIDTSTTIFGTKVKFPFGFSPTAMQQLAHPDGEEGTAKATATVGVPMGLSNYSTIELEKVISHGKGNPYVMQMSLLKNKDAMIQMIKRAEKAGFKALLVTLDAPYLGRRLNEFRNKFSVPQGMEYPNLFPGVDVTNLEDGDESMAYDCGLEWPQLMPFFRKHTKMEIWGKGIYTADDAELAIKHGLDGIVVSNHGGRQLDSVPASLDVLREVVPIAKGHIPIAVDGGIRRGTDIFKALALGADFCLAGRPAIWGLAYNGEKGVELALNLLYDEFKTCMALAGCKNVNEITKDYISLLQPDGRLSKLSRSSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDY0</accession>
    <name>C7ZDY0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_54791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043637.1">
        <property type="nucleotide sequence ID" value="XM_003043591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZDY0"/>
    <dbReference type="GeneID" id="9669474"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_54791"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_54791"/>
    <dbReference type="eggNOG" id="ENOG502T5XG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065406_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZDY0"/>
    <dbReference type="OMA" id="GQPEAFC"/>
    <dbReference type="OrthoDB" id="5130748at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="274" mass="30229" checksum="80CE05848E98DF93" modified="2009-10-13" version="1">MDQPSSSGRPIKREPPSTPGGSILVSSRSPSPAPRSTKRSRDRLFAALQLGNPLIRGPRTISTADHLDELELKRCFEILHACGAATDPNATLMSTRDTMEGFLDAVFKEWTGNFEDELPKPAMDFVVREFVSVGNICGKPANHSTSKSCADSPACTTPVFLVATYRSRPAQLEAGFCIDEPARNPNEQVEDLFCPMERTDIRWEDGDWLGVLKSEMSRACTAKIHKYNKHLAVWYARSLVRGWAMGSVSMGEDREVLGFLGRESVDAVFAMMGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDY2</accession>
    <name>C7ZDY2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_105739</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043523.1">
        <property type="nucleotide sequence ID" value="XM_003043477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZDY2"/>
    <dbReference type="STRING" id="660122.C7ZDY2"/>
    <dbReference type="GeneID" id="9669475"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_105739"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_105739"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="InParanoid" id="C7ZDY2"/>
    <dbReference type="OMA" id="RYKWLVG"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF295">
        <property type="entry name" value="ACETYL-COA SYNTHETASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="43"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="520"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU37810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="631" mass="68789" checksum="2DDDAB3FF7372121" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZE03</accession>
    <name>C7ZE03_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_98052</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043532.1">
        <property type="nucleotide sequence ID" value="XM_003043486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZE03"/>
    <dbReference type="GeneID" id="9669559"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_98052"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98052"/>
    <dbReference type="eggNOG" id="ENOG502SK2W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027816_3_0_1"/>
    <dbReference type="InParanoid" id="C7ZE03"/>
    <dbReference type="OMA" id="SKASWTC"/>
    <dbReference type="OrthoDB" id="294730at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF479">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="51"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU37819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="467" mass="50579" checksum="798F8EA15EF31035" modified="2009-10-13" version="1">MSTPNESIKTSPVEKDANLDRKHSDPAASEEVGGVFGGEGGKNFRVMGRKSTLFALLTNQFGIAALGLPSAYRDIGIVPGIIVTWGTALLAWYTGYEFWRFYCRHPHCVTVIDMARTAGGRFWEVIVGIAFVIQLNMCCASASVTLSIGFNSIGDHSMCTVGFIGIACLISYLLCIPRTMKFVAQSGLPCMISIIAAVLITMISIGVSKPNLAEDGWKPDLKVANNPGFKTIFNAVLKIVWAFAGHHAYVSYMAEMRDPVKDFPWALSWLGIIGASFYTFLAVGIYCLSGEYTTSPALGAAPRIAAKAAYGIVIPAIVTAALANGHIGIKYVFVVVMRKMNALNEITANTPKSWGVWVTIATVFWIVAFIISNAIPIFDSLVSIQSATTYAWFSFGIASVLWFSWNKGNYFKSPKQIAFFCLNVSIVGWAFFLNGCGLWSSITQMLDIFASDKGVNGSFSCGDNSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEL5</accession>
    <name>C7ZEL5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-acetolactate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_97702</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S)-2-acetolactate + H(+) = (R)-acetoin + CO2</text>
            <dbReference type="Rhea" id="RHEA:21580"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15686"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="4.1.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; (R,R)-butane-2,3-diol biosynthesis; (R,R)-butane-2,3-diol from pyruvate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-acetolactate decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.5" evidence="4"/>
    <dbReference type="EMBL" id="GG698921">
        <property type="protein sequence ID" value="EEU37719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043432.1">
        <property type="nucleotide sequence ID" value="XM_003043386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEL5"/>
    <dbReference type="STRING" id="660122.C7ZEL5"/>
    <dbReference type="GeneID" id="9669317"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_97702"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_97702"/>
    <dbReference type="eggNOG" id="ENOG502S81V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072561_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZEL5"/>
    <dbReference type="OMA" id="GEAYHFT"/>
    <dbReference type="OrthoDB" id="509395at2759"/>
    <dbReference type="UniPathway" id="UPA00626">
        <property type="reaction ID" value="UER00678"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047605">
        <property type="term" value="F:acetolactate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045151">
        <property type="term" value="P:acetoin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17299">
        <property type="entry name" value="acetolactate_decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.80">
        <property type="entry name" value="Hypothetical protein, similar to alpha- acetolactate decarboxylase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005128">
        <property type="entry name" value="Acetolactate_a_deCO2ase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01252">
        <property type="entry name" value="acetolac_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35524">
        <property type="entry name" value="ALPHA-ACETOLACTATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35524:SF1">
        <property type="entry name" value="ALPHA-ACETOLACTATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03306">
        <property type="entry name" value="AAL_decarboxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001332">
        <property type="entry name" value="Acetolac_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117856">
        <property type="entry name" value="AF0104/ALDC/Ptd012-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0005">Acetoin biosynthesis</keyword>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU37719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="240" mass="25635" checksum="B31048B1424A140D" modified="2009-10-13" version="1">MSSNQLFQYSVVSALMDGVAETGITISDLVAHGDHGLGTFRHMVGEMIILDGVIYDMKPDGSVVAIDSTACAEQSAPFAMVTRFEPTATISRPLQNKDTLAQALSQLLPGTKNHYVAFRVDGVFKAVTVRTVGGQKSPGERLAELGKRQVSHSFEQVRGTIIGFRSPVFMQGVSVAGDHLHFISENRDSGGHVLTLESGDDLTIAAAPITAVHLQLPSNDEDYNQAELARDDKGIAAVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEN5</accession>
    <name>C7ZEN5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_12626</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043076.1">
        <property type="nucleotide sequence ID" value="XM_003043030.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEN5"/>
    <dbReference type="GeneID" id="9665266"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_12626"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_12626"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007784_2_0_1"/>
    <dbReference type="InParanoid" id="C7ZEN5"/>
    <dbReference type="OMA" id="PSCEAEW"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF10">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="41"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU37363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="546" mass="61085" checksum="0530F89B30AABFED" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZER2</accession>
    <name>C7ZER2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_86235</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043048.1">
        <property type="nucleotide sequence ID" value="XM_003043002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZER2"/>
    <dbReference type="GeneID" id="9665182"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86235"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86235"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="InParanoid" id="C7ZER2"/>
    <dbReference type="OMA" id="AMSVERW"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF3">
        <property type="entry name" value="HEXOSE TRANSPORTER PROTEIN (AFU_ORTHOLOGUE AFUA_8G04480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="36"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU37335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="525" mass="57796" checksum="E6395841223D6156" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFN8</accession>
    <name>C7ZFN8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_78431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698923">
        <property type="protein sequence ID" value="EEU37203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042916.1">
        <property type="nucleotide sequence ID" value="XM_003042870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFN8"/>
    <dbReference type="STRING" id="660122.C7ZFN8"/>
    <dbReference type="GeneID" id="9665126"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78431"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78431"/>
    <dbReference type="eggNOG" id="ENOG502RVWB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024198_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZFN8"/>
    <dbReference type="OMA" id="CCEAMEN"/>
    <dbReference type="OrthoDB" id="4763081at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU37203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="508" mass="57050" checksum="2C28B736E6A3814E" modified="2009-10-13" version="1">MADDDYRGHLGLFPQCVIGDNDSTSYRGHTRPFPFPQPGYTRTRANGYLLCRYPGCKGCAASPEFIPIHCDCCEIFKANCYVEDTDVLSRLWTFAAWKKPWRGTLPIHLANRGIDMHMLKRTAQLAGLPLLCKLPMELLEMIRGYSHYSLFWRCISALLLANRVSSTELKPLVTMSLSRILSWERNGSLEHDTPDSLPPAIRLTINSGGISKIDSISCEQRYSRECYDHSLFVVVRRELVSDVTAQLQNGLLRLHLPSRIPSLPIWNTPVPPSLSSCAARPARLSTWKRFTAVEMDNIRGITFFFSSGLIKGIHVHHSEESSAQWAFDRFSNRPRRYLVWIHLPMPKGDRLLVLGTREHPDIGYNILARTQLSGDVILGTHIRSGFTDRCLAKQAPITLIHGEPRENHPIPFFGAYSKSAAYSGLPSRFPLQRPGPSPIGEDSFFSSAPLESVSSARTFYDETTGFCRGIMLQYENGGCRTLGQCRIHSKFAFGSSLMKMTGVICFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZGG1</accession>
    <name>C7ZGG1_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_106174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698925">
        <property type="protein sequence ID" value="EEU36928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042641.1">
        <property type="nucleotide sequence ID" value="XM_003042595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZGG1"/>
    <dbReference type="GeneID" id="9670141"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_106174"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_106174"/>
    <dbReference type="eggNOG" id="ENOG502QVB5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_976925_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZGG1"/>
    <dbReference type="OMA" id="NDSRCFL"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU36928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="285" mass="30024" checksum="6188C93C64138D5F" modified="2009-10-13" version="1">MAWNANSYDHSAEKQPTAGPADINSPEVIHPDHIHRASNYLEERDPKYYYEPEKTQQVAVPMPLSVDSQTEKGGGNADGVPKKKIWGIRRGLFISAVVITLIIIGAAVGGGVGGSLASKKSTPKEAAVTSSAGQEDATTQSLEITSTPTTPAPTTKSRTTTTTKPTSTPRVDASAGADRKSMMTTLETVVETTTSAAPSSTAVCAEGTVAEGETQNYLGLCKFSCGYGYCPPGPCTCTAYGKAKQAPDVINLGYVIMVVIINELSVSHKIKEQCDKRTTALNPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZGG9</accession>
    <name>C7ZGG9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_81085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698925">
        <property type="protein sequence ID" value="EEU36934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042647.1">
        <property type="nucleotide sequence ID" value="XM_003042601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZGG9"/>
    <dbReference type="GeneID" id="9669984"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_81085"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_81085"/>
    <dbReference type="HOGENOM" id="CLU_1321209_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZGG9"/>
    <dbReference type="OrthoDB" id="10557767at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU36934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="208" mass="22712" checksum="7A6C39831E01028E" modified="2009-10-13" version="1">MYTLNQAALCQACAQSHHISGKAGPLAEPSRAGTASNNNTQSTYDEDDEPVKRERVYGRDITEKPITPSPSRIPSLPDSTSTLNPSRTFSNIITMERPAQQTTTAPTADTTSEMPTHTVPQMHGILPSDSTGSRERDAGDKKNKVEEARADEAKMDEAKADETKAAEDARMKGCLADSWERVERALAQGDENFFRKYPQLEGLPTEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZGS0</accession>
    <name>C7ZGS0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_81141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698925">
        <property type="protein sequence ID" value="EEU36963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042676.1">
        <property type="nucleotide sequence ID" value="XM_003042630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZGS0"/>
    <dbReference type="STRING" id="660122.C7ZGS0"/>
    <dbReference type="GeneID" id="9670086"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_81141"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_81141"/>
    <dbReference type="eggNOG" id="ENOG502SEK1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1586920_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZGS0"/>
    <dbReference type="OMA" id="CADDYIF"/>
    <dbReference type="OrthoDB" id="3945378at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU36963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="168" mass="17976" checksum="40C2DDA9E968103C" modified="2009-10-13" version="1">MTNVNGFEGNSDLYGMGVRIGLYTQWIATLLVTLFIPSDEATHRAVNLVIQSAIFIGLCTESNEKVNAVGSVITMALLCGSLSSVTGDGICHLDRLVGLFRVAFYTALSAYGCWFWFSGIDRMASSGSEQIVFFGATSIHSGIRTFGKVVSVIGLVATTVLTCLSEWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZGU2</accession>
    <name>C7ZGU2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_55715</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698926">
        <property type="protein sequence ID" value="EEU36774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042487.1">
        <property type="nucleotide sequence ID" value="XM_003042441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZGU2"/>
    <dbReference type="STRING" id="660122.C7ZGU2"/>
    <dbReference type="GeneID" id="9669820"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55715"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55715"/>
    <dbReference type="eggNOG" id="KOG4245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039329_5_1_1"/>
    <dbReference type="InParanoid" id="C7ZGU2"/>
    <dbReference type="OMA" id="EWEDIAY"/>
    <dbReference type="OrthoDB" id="432010at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF30">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="80"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU36774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="333" mass="37155" checksum="4F5FBFF48D9CA027" modified="2009-10-13" version="1">MPKPLPPLITLEEHFVSAKLLPELSDIYEEQLKHLPDVSARLTDLATLRIQDMDTNRISLQVVSHAPGLGPRPLHLSSLANDELAQAVRANPQRLAGLAVLPMAEPESAAAELRRCVRELGFVGALVDAHVDGTHYDDPRFWPVFVAAAELDVPIYLYPTYPGETQRSAYEGNYVAGAARSLGSSGFGWHQDTGLGVLKLFAAGLFDELPTLKIVVGHFGEMLPFMLERVEKLSARWGERQRPWRQVWDENIWITTSGVWSVALMACILRNTRVDHILYSVDYPFEKNENGLRWIRELQDSGLVTPEELEMIAYRNAGRLLRVRAGSPGKSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZGX7</accession>
    <name>C7ZGX7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_51668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698927">
        <property type="protein sequence ID" value="EEU36598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042311.1">
        <property type="nucleotide sequence ID" value="XM_003042265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZGX7"/>
    <dbReference type="GeneID" id="9669639"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51668"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51668"/>
    <dbReference type="eggNOG" id="ENOG502S6PS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_7_1_1"/>
    <dbReference type="InParanoid" id="C7ZGX7"/>
    <dbReference type="OMA" id="VWAIDMG"/>
    <dbReference type="OrthoDB" id="184880at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU36598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="38685" checksum="7B11CD71C9A9A5F5" modified="2009-10-13" version="1">MPEDERQESPPSTEEATAQDVPRDPHIDVDDAPADEGYTTDAQSTTSTSIASSVRDYQFENSRRYHKFKEGLYQFPNDVPEQEREDMKHTVAVHLLGGKLHNAPLEDPQKIVDIGTGTGSWAIDMGDEYPGAEVIGIDLSPIQPPWVPPNVRFLVDDAEAPWLFGQDSLDLVHMRNMSTAIKDWDKLLGQAYSNLKPGGWIELPEFRWVYGCDDGTMHPDFTPPKMVANIKEGLATFGVDMHASEKNEERIRKAGFVNVRHEIKKVPVGPWAKDRSLKTIGLYNRSIIYDGLQAITMGPFTRGLGWTPEEVEVFLVKVRKDLMDSSVHSYVHFHSLCAQKPKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZH98</accession>
    <name>C7ZH98_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Manganese lipoxygenase</fullName>
            <ecNumber evidence="3">1.13.11.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_51785</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(9Z,12Z)-octadecadienoate + O2 = (11S)-hydroperoxy-(9Z,12Z)-octadecadienoate</text>
            <dbReference type="Rhea" id="RHEA:18993"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:57467"/>
            <dbReference type="EC" id="1.13.11.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.13.11.45" evidence="3"/>
    <dbReference type="EMBL" id="GG698927">
        <property type="protein sequence ID" value="EEU36715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042428.1">
        <property type="nucleotide sequence ID" value="XM_003042382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZH98"/>
    <dbReference type="GeneID" id="9669506"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51785"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51785"/>
    <dbReference type="eggNOG" id="ENOG502QQSP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009802_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZH98"/>
    <dbReference type="OMA" id="EVWDKGV"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050584">
        <property type="term" value="F:linoleate 11-lipoxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043651">
        <property type="term" value="P:linoleic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034440">
        <property type="term" value="P:lipid oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.245.10">
        <property type="entry name" value="Lipoxygenase-1, Domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000907">
        <property type="entry name" value="LipOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013819">
        <property type="entry name" value="LipOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036226">
        <property type="entry name" value="LipOase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11771">
        <property type="entry name" value="LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00305">
        <property type="entry name" value="Lipoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48484">
        <property type="entry name" value="Lipoxigenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51393">
        <property type="entry name" value="LIPOXYGENASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoxygenase" evidence="10">
        <location>
            <begin position="91"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="119"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU36715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="732" mass="83028" checksum="0BBB9AE3063601B3" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHH9</accession>
    <name>C7ZHH9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_42613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698928">
        <property type="protein sequence ID" value="EEU36470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042183.1">
        <property type="nucleotide sequence ID" value="XM_003042137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHH9"/>
    <dbReference type="GeneID" id="9669365"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_42613"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_42613"/>
    <dbReference type="eggNOG" id="ENOG502SMAU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2250789_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZHH9"/>
    <dbReference type="OMA" id="MTTICAT"/>
    <dbReference type="OrthoDB" id="5275938at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU36470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="11147" checksum="C3EB6B00577A1103" modified="2009-10-13" version="1">MGDNRGKKRPAEEAFADDLEFDRIAPNGDVTFVLDEGNTRVRVNSAVMKNASPVFAAMLGPNFKEGHALSAGDCASVDVPLPEDDAVAFGWVCRVLHSQADTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHT1</accession>
    <name>C7ZHT1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_81290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698928">
        <property type="protein sequence ID" value="EEU36492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042205.1">
        <property type="nucleotide sequence ID" value="XM_003042159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHT1"/>
    <dbReference type="GeneID" id="9669236"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_81290"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_81290"/>
    <dbReference type="HOGENOM" id="CLU_380391_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZHT1"/>
    <dbReference type="OrthoDB" id="5225164at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051616">
        <property type="entry name" value="Cul2-RING_E3_ligase_SR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054464">
        <property type="entry name" value="ULD_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224:SF64">
        <property type="entry name" value="IQ MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22893">
        <property type="entry name" value="ULD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="165"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU36492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="728" mass="80456" checksum="3A435C7C15E3A154" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHY7</accession>
    <name>C7ZHY7_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_72799</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698929">
        <property type="protein sequence ID" value="EEU36299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042012.1">
        <property type="nucleotide sequence ID" value="XM_003041966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHY7"/>
    <dbReference type="STRING" id="660122.C7ZHY7"/>
    <dbReference type="GeneID" id="9674411"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_72799"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_72799"/>
    <dbReference type="eggNOG" id="ENOG502SJYW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015933_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZHY7"/>
    <dbReference type="OMA" id="ECNSHIC"/>
    <dbReference type="OrthoDB" id="427518at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU36299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="524" mass="59676" checksum="446A293AC620636A" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZIF6</accession>
    <name>C7ZIF6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_87125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698930">
        <property type="protein sequence ID" value="EEU36255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041968.1">
        <property type="nucleotide sequence ID" value="XM_003041922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZIF6"/>
    <dbReference type="GeneID" id="9674290"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87125"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87125"/>
    <dbReference type="HOGENOM" id="CLU_1434789_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZIF6"/>
    <dbReference type="OrthoDB" id="5053136at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU36255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="189" mass="20810" checksum="7B6A355E65163C58" modified="2009-10-13" version="1">MYRAKSPVLCSALKSGAARGAVTWVTCELVSIKVPDSVSRHGLSGSAGPRPSRTTAFALAAFLQIPQRLVPNHPRATYPIFSFSAVFASSFIQMPPNVLFRHEIPKVLIINEPNLDLALIRTYGTAFMKTVEEDKWVILTPNITPEDLKKHLFNAGILFPESALKPEERSVPNPGFIVTDEQPETPKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZIM7</accession>
    <name>C7ZIM7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_72854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698931">
        <property type="protein sequence ID" value="EEU36115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041828.1">
        <property type="nucleotide sequence ID" value="XM_003041782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZIM7"/>
    <dbReference type="GeneID" id="9674218"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_72854"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_72854"/>
    <dbReference type="eggNOG" id="ENOG502SPD0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117282_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZIM7"/>
    <dbReference type="OMA" id="CTFIVEA"/>
    <dbReference type="OrthoDB" id="5352317at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002987134" description="Small secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU36115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="15265" checksum="A70FA59262245A01" modified="2009-10-13" version="1">MKFSITIVAALLSATGMAAPANEVSMMAASPQWTIQTLNRVCDKPDATCTWNFKINTGSGAATACKYVVKSTKTAKASKANGGPATCGDFTITSGWSGQFGADKGFTTLSVVSKSKKQIVYPAYTDQQLAGGKVVKPDQAYAPASLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZIV7</accession>
    <name>C7ZIV7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_53081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698931">
        <property type="protein sequence ID" value="EEU36153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041866.1">
        <property type="nucleotide sequence ID" value="XM_003041820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZIV7"/>
    <dbReference type="FunCoup" id="C7ZIV7">
        <property type="interactions" value="179"/>
    </dbReference>
    <dbReference type="GeneID" id="9674132"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_53081"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_53081"/>
    <dbReference type="eggNOG" id="KOG4754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039184_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZIV7"/>
    <dbReference type="OMA" id="NWVDARL"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU36153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="33729" checksum="4FF99D819930FA4B" modified="2009-10-13" version="1">MSNSTCTYRFSSEGGRFINYVEAARASPQSKLTTQPNLGLLDVVHESDAGSSGKDQGWGGLARYVQRCNDEIEPGVSYKVLLVVRHGRGVHNVVMDEVGSAEWKKRWSKLDGDGNRTWFDAELVDEGIEQAKALGTLYNEGVKHNNFPIPDTLYTSPLARCLETTKLVFRDVVEGHRRTFKPVVKELLRERLTDHTCDRRRDKKWISTAYPEYELEATFAEEDLLWHADRSESNIEHVARTQNLLEDIWSQDSGVFIALVTHSYALSSILEVIHAPLFRVGEGVMTAFLVKGQRVEMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJ26</accession>
    <name>C7ZJ26_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PPPDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_72124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698932">
        <property type="protein sequence ID" value="EEU36002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041715.1">
        <property type="nucleotide sequence ID" value="XM_003041669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJ26"/>
    <dbReference type="GeneID" id="9673994"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_72124"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_72124"/>
    <dbReference type="eggNOG" id="ENOG502RY7N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053718_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZJ26"/>
    <dbReference type="OMA" id="VEIGWHP"/>
    <dbReference type="OrthoDB" id="3431913at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU36002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="34170" checksum="EA0E5BBA5FA70B87" modified="2009-10-13" version="1">MSDEEKEKERRRDKVAEFLKKNLDKGELALKHAAGLGHQPNVVPVTDPVMDGPLRDVEVGWHPVGGVAGKWFAEDTGLGKMITEKINRYPDPTQHWAVLVGDYAHQLWMDENFDVIYTNEKINREEWHTFKVGETRFNDDATRRAGESVIQSIRDRQPAYNLITNNCQTYALQLLDAIKVGVAKEFGTTLAVYERLFGSGKVKDLFEHGDVQIQEGEDATAGQGTVSFAQQVMNENTTQLEPEAELKKHKQQREEAEQEQSRSLQLDGEDKEEKEEKEKSSYKEVKERFGGFVSRFKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJ84</accession>
    <name>C7ZJ84_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_72141</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698932">
        <property type="protein sequence ID" value="EEU35969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041682.1">
        <property type="nucleotide sequence ID" value="XM_003041636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJ84"/>
    <dbReference type="STRING" id="660122.C7ZJ84"/>
    <dbReference type="GeneID" id="9674021"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_72141"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_72141"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_6_16_1"/>
    <dbReference type="InParanoid" id="C7ZJ84"/>
    <dbReference type="OMA" id="NINARIF"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
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    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="186"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="751"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU35969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="953" mass="106869" checksum="A88A276BECF4BA32" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJE0</accession>
    <name>C7ZJE0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_58744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698933">
        <property type="protein sequence ID" value="EEU35889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041602.1">
        <property type="nucleotide sequence ID" value="XM_003041556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJE0"/>
    <dbReference type="FunCoup" id="C7ZJE0">
        <property type="interactions" value="42"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZJE0"/>
    <dbReference type="GeneID" id="9673973"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_58744"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_58744"/>
    <dbReference type="eggNOG" id="KOG2789">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009068_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZJE0"/>
    <dbReference type="OMA" id="CFLTYPP"/>
    <dbReference type="OrthoDB" id="21471at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24139">
        <property type="entry name" value="SIP5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039301">
        <property type="entry name" value="Sip5/DA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31315">
        <property type="entry name" value="PROTEIN SIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31315:SF1">
        <property type="entry name" value="PROTEIN SIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="380"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="466"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="536"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="736"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="380"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="470"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="536"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="571"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="605"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="618"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="640"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="665"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU35889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="830" mass="88996" checksum="DF27BB03FEBC68A1" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZK38</accession>
    <name>C7ZK38_FUSV7</name>
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        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_97353</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698937">
        <property type="protein sequence ID" value="EEU35610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041323.1">
        <property type="nucleotide sequence ID" value="XM_003041277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZK38"/>
    <dbReference type="GeneID" id="9675995"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_97353"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_97353"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_2_1"/>
    <dbReference type="InParanoid" id="C7ZK38"/>
    <dbReference type="OMA" id="YAWVCTF"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF315">
        <property type="entry name" value="TRANSPORTER MCH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="213"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU35610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="404" mass="43207" checksum="CEFA12CF66620E98" modified="2009-10-13" version="1">MEAMDGFAPLPFSSSIPIPGVSMLQSWAVIMAYYATHPKEMPASFFEYSLVGGLSISAALITSPLVTVVRKRIGLRLTLILGSVLLFISLITSSFATKIWQLFLSQGVCFGLGMGLSYISGAAVLPPWFTSRRSLAVGCATAGVGLGGLVYSIAANQLIEDVGIRWTYRVLAFCGLGANLLAAFLLKEWGGRAQPDMRLDEERFNPRDFGRIEILLLIAWGFATDLGYVILLYSLPTYASSIGLTPAQGAISSALLNLGMALSRPLIGYLSDSFGRINMAGILTFLCTISCFAIWLPATTYALLLVFSLIGGALCGVFWCTITPVMVEVVGIQKLASTFGSLCIAMAIPTTFGGPLAMQIAGSGENLKFTEAQLFVGFMFLTGTLSLGNPTKRYQKVFKAPPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZK69</accession>
    <name>C7ZK69_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_72769</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698937">
        <property type="protein sequence ID" value="EEU35622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041335.1">
        <property type="nucleotide sequence ID" value="XM_003041289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZK69"/>
    <dbReference type="GeneID" id="9676138"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_72769"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_72769"/>
    <dbReference type="eggNOG" id="ENOG502S13F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038839_2_0_1"/>
    <dbReference type="InParanoid" id="C7ZK69"/>
    <dbReference type="OMA" id="FYTVDDR"/>
    <dbReference type="OrthoDB" id="5422068at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF31">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G12650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="11"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU35622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="388" mass="43584" checksum="ADDB87CB5550A81C" modified="2009-10-13" version="1">MPADLAHNLTITAQCLCKAHSYSTSISRSSLPLQGSICHCKSCRHVTGAMYTSHIKWPGLTREILSSDLARYEFTSNVSLLFCGTCSSPLFWEEYYKDRPEVLDVFTGALNNVAVKNLITFPDQIFVGDTEDGGVSQWLVDVNEDGIESRRWKARAIKNETFDHDRPTLVGASNDDPQSPRDIPIQCRCKGVDLVLRRFPDDFSPGETDSLPFFVDPTTHKHLATFDACNTCRSVFGVETVNWTFALLRQIYFVRDRKLPSFPQSVQELEKAVSSPDKDARLGTLSLYKSSPDVQRYFCSRCSASVLYAVDDRPDLVDVAVGLLDAPEGARAERDLIWNLGSRVGGEDDVVGGWREGFVNRVKETAEKWRVDRGYLKTWRRFAAEDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKQ1</accession>
    <name>C7ZKQ1_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_86231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698940">
        <property type="protein sequence ID" value="EEU35442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041155.1">
        <property type="nucleotide sequence ID" value="XM_003041109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKQ1"/>
    <dbReference type="GeneID" id="9675685"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86231"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86231"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_987277_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZKQ1"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510:SF1">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="282" mass="30114" checksum="D2A170CFC16CD0C8" modified="2009-10-13" version="1">MKNVQGFKIDDWVRVHGANSRFGLEGSYVSALSMNDLQQLSTDPTLEVVNRDMEVSYGSFEGSLELREGIAALNSSEGSKLTAENVIITPLSIMANYLVLDTICQSRACKKSVAGPNPSNGPGLSMRPRANTISHVDSSTMKMIAAANASVQGGIPPTYTHSRRLSLAGLPIPSLDRGILATMGQRGLQHGLPKLETSTLGSLDFSNGLRTAPPVAAAFNTEFDFEGLFGSGSTINPDALHYNRSPQLTALEQASPFAPPMNETPSRQTLDDSFDGLTGFEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKW3</accession>
    <name>C7ZKW3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA (guanine(10)-N(2))-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.214</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_94203</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.214" evidence="9"/>
    <dbReference type="EMBL" id="GG698941">
        <property type="protein sequence ID" value="EEU35400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041113.1">
        <property type="nucleotide sequence ID" value="XM_003041067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKW3"/>
    <dbReference type="FunCoup" id="C7ZKW3">
        <property type="interactions" value="842"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZKW3"/>
    <dbReference type="GeneID" id="9675536"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94203"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94203"/>
    <dbReference type="eggNOG" id="KOG2671">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029646_3_0_1"/>
    <dbReference type="InParanoid" id="C7ZKW3"/>
    <dbReference type="OMA" id="AFNKWSR"/>
    <dbReference type="OrthoDB" id="296065at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043528">
        <property type="term" value="C:tRNA (m2G10) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160102">
        <property type="term" value="F:tRNA (guanine(10)-N2)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016691">
        <property type="entry name" value="TRMT11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059073">
        <property type="entry name" value="TRMT11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25904">
        <property type="entry name" value="Tmrp11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017259">
        <property type="entry name" value="tRNA_mtfrase_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51627">
        <property type="entry name" value="SAM_MT_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA (guanine(10)-N(2))-methyltransferase TRMT11 N-terminal" evidence="12">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase" evidence="11">
        <location>
            <begin position="182"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU35400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="444" mass="50260" checksum="4898A901FE547B84" modified="2009-10-13" version="1">MDFLIKFAQAHESFRVAEIEALALVEGLDMKIIEYSEDSPFCVVRLPSVEAAKKLIKRSILGQSIHELWGRGSTLEDVHNAVKSDTSHLWDQYMDKSFRFEVEPFQGSRSAKKRLELINSFRFLGWKGPVKMSNPDNMFTIFEMWPFNSVPLKIPDPRAIYLGRYVASSSREILVRFDLKKRGYISTTSMDSELALVTANIALAAPGKLFYDPFVGTGSFPVACAHFGALAWGSDIDGRSIRGEGGKKSLLGNFQQYGLTSCLGDVFSSDLTNSPIRRQRRTWDGIVCDPPYGVREGLRVLGLRDPEKTPWLIEQGKERGMNPDYVPPKKPYSFLIMLDDILSFAVDTLVDNGRLSFWMPTANEEELEIPVPTHPCLEIVVVCVQPFNKWSRRLITYRRLPDSEVSQPALEAYASRQKLTVNGTSADELNPFRRGYFNKFEADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLA5</accession>
    <name>C7ZLA5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_102106</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698944">
        <property type="protein sequence ID" value="EEU35201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040914.1">
        <property type="nucleotide sequence ID" value="XM_003040868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLA5"/>
    <dbReference type="GeneID" id="9675244"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102106"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102106"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="C7ZLA5"/>
    <dbReference type="OMA" id="FAWGGIT"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF49">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="51"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU35201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="425" mass="46369" checksum="CC0378AF9C87F8BD" modified="2009-10-13" version="1">MPSTTNIDTRVDIADDLAAVEKHGSDGGLENATAIDPKLQSLLLRKQDARIIPLAAGIYLLCYLDRSNIGNAKVLNASTKHDLLSETGMSNLDYTIALMVFLIAYALFEVPSNYFLKRMKPSRWISFLMFSWGTITMCLGAAHNYGSVTAMRFLLGVFEAGLFPGLVYYLTFWYRPEERSLRVATILASATLAGAFGGAIAYGVGHMNQVGGLSGWRWLFILEGAPSVVSAALVWFCLPDYPETAKWLSLEEKDLAAARLAEQGSHGSSKSMTWEDAKSTLLEWRLWCHYLIYFGISAPFSSLSLFTPSITAGLGPRYGCLIVAACGSFACIPPLLGWLSSNLQSTAAIGLAIALNISMGAPGQIVGVWIYKAEEAKKGYPTGHWTNAGLLLFVSVGCIVMHFYYVWRNRRAGAGDPIFKLYNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLS7</accession>
    <name>C7ZLS7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome assembly protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_37426</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for efficient biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RSA3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698947">
        <property type="protein sequence ID" value="EEU35012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040725.1">
        <property type="nucleotide sequence ID" value="XM_003040679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLS7"/>
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    <dbReference type="KEGG" id="nhe:NECHADRAFT_37426"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_37426"/>
    <dbReference type="eggNOG" id="ENOG502SBU9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_181714_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZLS7"/>
    <dbReference type="OMA" id="DSKQMSQ"/>
    <dbReference type="OrthoDB" id="69550at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051898">
        <property type="entry name" value="Ribosome_Assembly_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028217">
        <property type="entry name" value="Rsa3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28127">
        <property type="entry name" value="RIBOSOME ASSEMBLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28127:SF1">
        <property type="entry name" value="RIBOSOME ASSEMBLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14615">
        <property type="entry name" value="Rsa3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome-assembly protein 3 C-terminal" evidence="8">
        <location>
            <begin position="13"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU35012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="76" mass="8323" checksum="5B67C01F1B858AC1" modified="2009-10-13" version="1">MSSKPNNQASAEFTSYYLQRATQELSEDLDKVRNAEDFKADSIPFLVHALQQGAGLFSAEDQKRVVDGSKGKDGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLT6</accession>
    <name>C7ZLT6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inheritance of peroxisomes protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_37505</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for peroxisome inheritance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698947">
        <property type="protein sequence ID" value="EEU35016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040729.1">
        <property type="nucleotide sequence ID" value="XM_003040683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLT6"/>
    <dbReference type="STRING" id="660122.C7ZLT6"/>
    <dbReference type="GeneID" id="9679146"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_37505"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_37505"/>
    <dbReference type="eggNOG" id="ENOG502S7ZC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016546_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZLT6"/>
    <dbReference type="OMA" id="PMPCAWE"/>
    <dbReference type="OrthoDB" id="4097008at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005780">
        <property type="term" value="C:extrinsic component of intraperoxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045033">
        <property type="term" value="P:peroxisome inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024758">
        <property type="entry name" value="Inp1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12634">
        <property type="entry name" value="Inp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="179"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="376"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="664"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="235"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="465"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="513"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="674"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU35016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="722" mass="78928" checksum="CE9713D04037F622" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZM22</accession>
    <name>C7ZM22_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hydantoinase B/oxoprolinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_29377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698949">
        <property type="protein sequence ID" value="EEU34890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040603.1">
        <property type="nucleotide sequence ID" value="XM_003040557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZM22"/>
    <dbReference type="STRING" id="660122.C7ZM22"/>
    <dbReference type="GeneID" id="9679042"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_29377"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_29377"/>
    <dbReference type="eggNOG" id="KOG1939">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2694559_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZM22"/>
    <dbReference type="OrthoDB" id="5105584at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="74" mass="8143" checksum="8F686E351AF1AB73" modified="2009-10-13" version="1" fragment="single">EDESFINPIQLSIFSHRFTSIAEQMGRLLEKTSVSINIKERLDYLCAIFSPIGGLVANAPYIPCHLGAMSFAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZM98</accession>
    <name>C7ZM98_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_88380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698950">
        <property type="protein sequence ID" value="EEU34877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040590.1">
        <property type="nucleotide sequence ID" value="XM_003040544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZM98"/>
    <dbReference type="GeneID" id="9679003"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88380"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88380"/>
    <dbReference type="HOGENOM" id="CLU_023586_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZM98"/>
    <dbReference type="OrthoDB" id="5369347at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="602" mass="67551" checksum="4EB56A27544D3E52" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMF1</accession>
    <name>C7ZMF1_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_88435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698951">
        <property type="protein sequence ID" value="EEU34845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040558.1">
        <property type="nucleotide sequence ID" value="XM_003040512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMF1"/>
    <dbReference type="STRING" id="660122.C7ZMF1"/>
    <dbReference type="GeneID" id="9678967"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88435"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88435"/>
    <dbReference type="HOGENOM" id="CLU_2197625_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZMF1"/>
    <dbReference type="OrthoDB" id="5232980at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="108" mass="12322" checksum="05D34FE5BA273AA0" modified="2009-10-13" version="1">MSPQSGYSSTCKPNHDSRKKTHPTCLQAVSAQRWKGYIHRASVIFAWFISQADSVTVLSQPPPQRFHPSGRTFYQTVEEPIIQVMHLTMGGKAEDFRYEIWPSDKSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNG5</accession>
    <name>C7ZNG5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydrodipicolinate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_82289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698967">
        <property type="protein sequence ID" value="EEU34455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040168.1">
        <property type="nucleotide sequence ID" value="XM_003040122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNG5"/>
    <dbReference type="STRING" id="660122.C7ZNG5"/>
    <dbReference type="GeneID" id="9678004"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82289"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82289"/>
    <dbReference type="eggNOG" id="ENOG502SKWU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_0_2_1"/>
    <dbReference type="InParanoid" id="C7ZNG5"/>
    <dbReference type="OMA" id="PRQEIDY"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF47">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU34455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="35193" checksum="ED2416EEC90D3B18" modified="2009-10-13" version="1">MNRSTIQPKAKPLPAGVYTPVVTLYKAGDANQSVDHEAMFTQCQALIKAGMHGLVYLGTNGELALLTRDERKAILENVSRAASETGGSEYPLVAGISAQSTYETILNAKDAASAGANFALLLPPSYWAKALPSPALLAYFREVADQSPIPIVIYNFPNVTSGIDLDSDQLAALATHPNISAVKLTCGNVGKLTRLTSLFSHEQFGVFGGSSDYLLPTLQAGGSGCVTGMGNVFPWSTSAVYDLWKAGKVDEAKKLQDVVAHAEWACKKGIACTKYGAWHFFGRKIGVDQESSWEMRRPYQPLDEKMKTWSLDTLGVLANIEEKRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNM6</accession>
    <name>C7ZNM6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">NECHADRAFT_85441</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + H(+) = an aldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:11628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="EC" id="4.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039728.1">
        <property type="nucleotide sequence ID" value="XM_003039682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNM6"/>
    <dbReference type="STRING" id="660122.C7ZNM6"/>
    <dbReference type="GeneID" id="9677639"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85441"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85441"/>
    <dbReference type="eggNOG" id="KOG1184">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_0_2_1"/>
    <dbReference type="InParanoid" id="C7ZNM6"/>
    <dbReference type="OMA" id="HAIYIGM"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF3">
        <property type="entry name" value="TRANSAMINATED AMINO ACID DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="15">
        <location>
            <begin position="22"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="13">
        <location>
            <begin position="215"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="14">
        <location>
            <begin position="417"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEU34015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="592" mass="65162" checksum="77DF829C0CB95458" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZRB3</accession>
    <name>C7ZRB3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_56645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="GG699054">
        <property type="protein sequence ID" value="EEU33446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039159.1">
        <property type="nucleotide sequence ID" value="XM_003039113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZRB3"/>
    <dbReference type="STRING" id="660122.C7ZRB3"/>
    <dbReference type="GeneID" id="9666683"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_56645"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_56645"/>
    <dbReference type="eggNOG" id="KOG1535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_2_1_1"/>
    <dbReference type="InParanoid" id="C7ZRB3"/>
    <dbReference type="OMA" id="KWQRDPA"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF100">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G01490)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="77"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU33446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="294" mass="31873" checksum="E4A2587D5C48D931" modified="2009-10-13" version="1">MAWSRLIRFVDESGRITFGDPCINNSNELKELLDSQELYAVRLAGGDPFSLTRTEEKVKVQKLLGVLNAGDVPIFKCIGLNYRKHIAETGRTPPPYPSLFMKPGAAIAAFDEDICVHPIAQGKSLDYEGELAVVIGRAGKNISKEEAISYVAGYASSNDVSARTWQRDPAHAGSIPQWSYAKSFDTFAPLGPMLVSPALVGAADSLRLQTFVNGELRQDSNTDDLLFNVATIISFLSQGSTLQKGTVIMTGTPDGVVLGMPDPKPWLKDGDVVEVRIEQLGSCVNKVVNEVSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZRJ3</accession>
    <name>C7ZRJ3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_74387</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699095">
        <property type="protein sequence ID" value="EEU33363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039076.1">
        <property type="nucleotide sequence ID" value="XM_003039030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZRJ3"/>
    <dbReference type="STRING" id="660122.C7ZRJ3"/>
    <dbReference type="GeneID" id="9666602"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74387"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74387"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032825_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZRJ3"/>
    <dbReference type="OMA" id="WFITVTK"/>
    <dbReference type="OrthoDB" id="2096480at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF13">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="7"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU33363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="648" mass="71977" checksum="F489969031B64C0E" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZRK4</accession>
    <name>C7ZRK4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_56801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699097">
        <property type="protein sequence ID" value="EEU33357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039070.1">
        <property type="nucleotide sequence ID" value="XM_003039024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZRK4"/>
    <dbReference type="STRING" id="660122.C7ZRK4"/>
    <dbReference type="GeneID" id="9667218"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_56801"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_56801"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001248_2_0_1"/>
    <dbReference type="InParanoid" id="C7ZRK4"/>
    <dbReference type="OMA" id="HDTKSAK"/>
    <dbReference type="OrthoDB" id="4917073at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU33357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="209" mass="23134" checksum="8ED29891BBCE04E9" modified="2009-10-13" version="1" fragment="single">EEATLIASVGDNSKIYVPATFIFVPSMPVVVTKNINPGLKLVNGAKYKALEVILDSKSFLGYQLASNIILHFRPPAGIILSSESTKKFKFNDIPPGTVLLTPTSAQIPIEKKKRAKKRPWQRHEVSRRGLPCTAAFACTDYKIQGETLVEITLELRGTGTKLNTTTRQLEPGKCDPYSLYMQLSRCKSLDSIMLLSKAWVQDIVGNKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZRM0</accession>
    <name>C7ZRM0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Xaa-Pro dipeptidyl-peptidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_89549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699104">
        <property type="protein sequence ID" value="EEU33336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039049.1">
        <property type="nucleotide sequence ID" value="XM_003039003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZRM0"/>
    <dbReference type="STRING" id="660122.C7ZRM0"/>
    <dbReference type="GeneID" id="9667197"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89549"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89549"/>
    <dbReference type="eggNOG" id="ENOG502SH88">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1235321_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZRM0"/>
    <dbReference type="OrthoDB" id="416441at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase C-terminal" evidence="1">
        <location>
            <begin position="92"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU33336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="199" mass="22755" checksum="C09B481E92C96AA2" modified="2009-10-13" version="1">MYGETWRSEGPWPVFDRTRDLSKLKVPILSAGNWMDSEVHFPGNLAAFERSSSRWKFLEIHTGNHIASYYEPAQTERQLIFFDYFLKGKTDNGLEATPRIDLLIRRGTNNSYRVEESWPPQDTIYTSLYLAPDEALSFDEFAASSEDDAISSAGLTGKDLFQSAPLKDFEILGYPNLDLAVSTDAKDMDIFIYFCHRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7YGW6</accession>
    <name>C7YGW6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_74765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054241.1">
        <property type="nucleotide sequence ID" value="XM_003054195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YGW6"/>
    <dbReference type="STRING" id="660122.C7YGW6"/>
    <dbReference type="GeneID" id="9676861"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74765"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74765"/>
    <dbReference type="eggNOG" id="ENOG502SU6X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018148_1_1_1"/>
    <dbReference type="InParanoid" id="C7YGW6"/>
    <dbReference type="OMA" id="MWKRLQG"/>
    <dbReference type="OrthoDB" id="4507572at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42023">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42023:SF1">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU48528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="695" mass="76838" checksum="68D0C9D7E8243213" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7YGX3</accession>
    <name>C7YGX3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_98787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054245.1">
        <property type="nucleotide sequence ID" value="XM_003054199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YGX3"/>
    <dbReference type="STRING" id="660122.C7YGX3"/>
    <dbReference type="GeneID" id="9676864"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_98787"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98787"/>
    <dbReference type="eggNOG" id="ENOG502S08D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012261_0_0_1"/>
    <dbReference type="InParanoid" id="C7YGX3"/>
    <dbReference type="OMA" id="QILNMPF"/>
    <dbReference type="OrthoDB" id="419770at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU48532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="644" mass="71091" checksum="17FB60DB9EEF613D" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHB1</accession>
    <name>C7YHB1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methylmalonate-semialdehyde dehydrogenase (CoA acylating)</fullName>
            <ecNumber evidence="2">1.2.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_57437</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.27" evidence="2"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053602.1">
        <property type="nucleotide sequence ID" value="XM_003053556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YHB1"/>
    <dbReference type="STRING" id="660122.C7YHB1"/>
    <dbReference type="GeneID" id="9674475"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_57437"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_57437"/>
    <dbReference type="eggNOG" id="KOG2449">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_10_1"/>
    <dbReference type="InParanoid" id="C7YHB1"/>
    <dbReference type="OMA" id="GGAKNHI"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000002">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase (Acylating)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000003">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase [acylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="MALONATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866:SF3">
        <property type="entry name" value="METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="55"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU47889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="542" mass="58314" checksum="278609CF0CF9D3A0" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7YI46</accession>
    <name>C7YI46_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_90290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053743.1">
        <property type="nucleotide sequence ID" value="XM_003053697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YI46"/>
    <dbReference type="STRING" id="660122.C7YI46"/>
    <dbReference type="GeneID" id="9664763"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90290"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90290"/>
    <dbReference type="eggNOG" id="KOG1212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_9_3_1"/>
    <dbReference type="InParanoid" id="C7YI46"/>
    <dbReference type="OMA" id="GMQPWKY"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="70"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEU48030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="549" mass="61187" checksum="FC66CE3FEA4A3973" modified="2009-10-13" version="1"> </sequence>
</entry>
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            <fullName evidence="3">DUF7492 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">NECHADRAFT_75253</name>
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        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003053731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIA8"/>
    <dbReference type="GeneID" id="9664534"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75253"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75253"/>
    <dbReference type="eggNOG" id="ENOG502SD68">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="RRRQNWV"/>
    <dbReference type="OrthoDB" id="64281at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="entry name" value="DUF7492"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002986239" description="DUF7492 domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="575"/>
        </location>
    </feature>
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        <location>
            <begin position="19"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU48064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="575" mass="61127" checksum="5FC95E459E8E1D1C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">NECHADRAFT_75560</name>
    </gene>
    <organism evidence="7 8">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Hypocreales</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
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                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
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            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="C7YJ55"/>
    <dbReference type="OMA" id="VICASGR"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
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        <property type="project" value="InterPro"/>
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    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00172">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
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        <location>
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            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU48208.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="607" mass="67524" checksum="17986655929D3649" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJP1</accession>
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        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_75747</name>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU49011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054724.1">
        <property type="nucleotide sequence ID" value="XM_003054678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJP1"/>
    <dbReference type="GeneID" id="9676645"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75747"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75747"/>
    <dbReference type="eggNOG" id="ENOG502SXT7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070615_2_0_1"/>
    <dbReference type="InParanoid" id="C7YJP1"/>
    <dbReference type="OMA" id="QRFICLY"/>
    <dbReference type="OrthoDB" id="2687452at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="152"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU49011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="242" mass="28698" checksum="7F8972FED999B12A" modified="2009-10-13" version="1">MDPYLHSSAYQQHMLPVYDEVVIEEVEPTRPTEETITYSYQYSSSSALETPQWPSSSTYKDPSEETPRSAEVPSTYSYPDSSSQILAESSQPANLYTSVYSRPRQFLSLYNLTCTSNHCLYPGCNVKPFKRSADLQRHYRNAHNPDSTKEAYHCDYPRCTRSNEPFSRRDHFRDHLREYHREDIQKRGIVVNKEWLEDRYYSDKWWRCPRCLVRVYTSKDEFECPQCKGSCEPKRKEKRRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJU2</accession>
    <name>C7YJU2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_75798</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU49036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054749.1">
        <property type="nucleotide sequence ID" value="XM_003054703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJU2"/>
    <dbReference type="GeneID" id="9676670"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75798"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75798"/>
    <dbReference type="eggNOG" id="ENOG502QTA0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006926_3_1_1"/>
    <dbReference type="InParanoid" id="C7YJU2"/>
    <dbReference type="OMA" id="QDIHTES"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF32">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="130"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU49036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="710" mass="78421" checksum="39E074BF3EDD6D79" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>C7YK24</accession>
    <name>C7YK24_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">NECHADRAFT_65406</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053380.1">
        <property type="nucleotide sequence ID" value="XM_003053334.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="C7YK24">
        <property type="interactions" value="198"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YK24"/>
    <dbReference type="GeneID" id="9676712"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_65406"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_65406"/>
    <dbReference type="eggNOG" id="KOG0605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000709_0_0_1"/>
    <dbReference type="InParanoid" id="C7YK24"/>
    <dbReference type="OMA" id="HNRRFVG"/>
    <dbReference type="OrthoDB" id="162894at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901992">
        <property type="term" value="P:positive regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05611">
        <property type="entry name" value="STKc_Rim15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000340">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000664">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000139">
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    <sequence length="1909" mass="209003" checksum="5CCFB2C7B1B0C92E" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7YK70</accession>
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        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
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        </source>
    </evidence>
    <sequence length="512" mass="55999" checksum="CF0CE45DCA545EFD" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C7YKG8</accession>
    <name>C7YKG8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <ecNumber evidence="3 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_98726</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="3 7"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053444.1">
        <property type="nucleotide sequence ID" value="XM_003053398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YKG8"/>
    <dbReference type="FunCoup" id="C7YKG8">
        <property type="interactions" value="342"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YKG8"/>
    <dbReference type="GeneID" id="9664173"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_98726"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98726"/>
    <dbReference type="eggNOG" id="KOG3243">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089358_2_0_1"/>
    <dbReference type="InParanoid" id="C7YKG8"/>
    <dbReference type="OMA" id="CQGVTQG"/>
    <dbReference type="OrthoDB" id="2965at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.960:FF:000005">
        <property type="entry name" value="6,7-dimethyl-8-ribityllumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="entry name" value="Lumazine/riboflavin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058:SF0">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE DMRL SYNTHASE LUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="Lumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU47731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="197" mass="20644" checksum="E4888CB2C27806F7" modified="2009-10-13" version="1">MSSLKGPSPQHHDGSNLRIAIVHARWNSTIIEPLVTGAKEKLLASGVKESNIVIQSCPGSWELPIAVQRLFSASQIQGTATGGPSATDLLASSTPDLSTLPASSGPFDAIIAVGVLIKGETMHFEYIAESTCQGLMRVQLDTGVPVILGVLTVLTDDQAKARAGVDGKGHNHGEDWGLAAVEMGVKRREWANGTIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7YKS8</accession>
    <name>C7YKS8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_77281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052845.1">
        <property type="nucleotide sequence ID" value="XM_003052799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YKS8"/>
    <dbReference type="STRING" id="660122.C7YKS8"/>
    <dbReference type="GeneID" id="9670928"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77281"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77281"/>
    <dbReference type="HOGENOM" id="CLU_915537_0_0_1"/>
    <dbReference type="InParanoid" id="C7YKS8"/>
    <dbReference type="OrthoDB" id="5103975at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NYN" evidence="2">
        <location>
            <begin position="69"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU47132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="304" mass="34725" checksum="236AB9E0BE056E68" modified="2009-10-13" version="1">MLSLYEDQPYLKALCKGLHQITPPAPSSKPWHILRPKIQPRPDAMLPPSPPPSPSPNGKISNDEDKRNTYVYIDHSNFWISRKIATGDQDWRYDVKSFTSLLTSNTVGTETTGSHHVEVHIYGYVPDDLKELWKNEHAKVHKLKKPHPLDTKEELGDEKKETKNQRKKKKKNAEKEVDTRLVADSVAEAARALHERLKDTQIEFVIVSGDRDMRPAVKKIINYGYKVRQVRYSIEARSDIPSGHFLGQELGKLKKATDREVEGRYMGRKAREMMWFRHGIMGKGRAALSALTIIIGSAKILQET</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7YL37</accession>
    <name>C7YL37_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_99495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052900.1">
        <property type="nucleotide sequence ID" value="XM_003052854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YL37"/>
    <dbReference type="GeneID" id="9663591"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_99495"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_99495"/>
    <dbReference type="eggNOG" id="KOG0593">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_315239_0_0_1"/>
    <dbReference type="InParanoid" id="C7YL37"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359:SF1">
        <property type="entry name" value="INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE EPSILON SUBUNIT HOMOLOG 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="74"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="769"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU47187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="927" mass="103359" checksum="CD9FFD2031EF4D8C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>C7YL75</accession>
    <name>C7YL75_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ABC transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_91658</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052924.1">
        <property type="nucleotide sequence ID" value="XM_003052878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YL75"/>
    <dbReference type="GeneID" id="9663615"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_91658"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_91658"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_17_2_1"/>
    <dbReference type="InParanoid" id="C7YL75"/>
    <dbReference type="OMA" id="MTTIREN"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001530">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF11">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="441"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="567"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="128"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="446"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="757"/>
            <end position="979"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU47211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="984" mass="108585" checksum="A9CE418DD5E49665" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C7YMF0</accession>
    <name>C7YMF0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_67451</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the bZIP family. YAP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052647.1">
        <property type="nucleotide sequence ID" value="XM_003052601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YMF0"/>
    <dbReference type="FunCoup" id="C7YMF0">
        <property type="interactions" value="288"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YMF0"/>
    <dbReference type="GeneID" id="9671179"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_67451"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_67451"/>
    <dbReference type="eggNOG" id="ENOG502S2TX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044874_0_1_1"/>
    <dbReference type="InParanoid" id="C7YMF0"/>
    <dbReference type="OMA" id="TQCDGQG"/>
    <dbReference type="OrthoDB" id="4940293at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000067">
        <property type="entry name" value="BZIP transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.100">
        <property type="entry name" value="YAP1 redox domain. Chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013910">
        <property type="entry name" value="TF_PAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023167">
        <property type="entry name" value="Yap1_redox_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF8">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08601">
        <property type="entry name" value="PAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111430">
        <property type="entry name" value="YAP1 redox domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="128"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="14"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU46934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="308" mass="33846" checksum="E71B7EBE8952F89C" modified="2009-10-13" version="1">MDFTGQYNFPGTQPYHQFMPIPPLTPSHSHSAGSDDFNASPPENYDNLPTNHNDQFQAFDYASQGFNGNPHQPATAFPGPPTPPGQNVFAAQVQSVHHQQQQHGAAKIDSPEDQNGVRGGSEEDDNLTPAQSRRKAQNRAAQRAFRERKEKHVKDLEAKLAGLEAAQQQASLENERLKRDLQKMSTENEILRATSHVGHGSISPEPATGPMRFNPTEFYSNVLQNHTNKSPSHRIVTADDGERLLAAGAAWDFIISHELFKKGLVDIGDVSERLKHCARCDGQGPVFSERAIKSAIEQSVASGTDDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7YMZ3</accession>
    <name>C7YMZ3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_35839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053246.1">
        <property type="nucleotide sequence ID" value="XM_003053200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YMZ3"/>
    <dbReference type="STRING" id="660122.C7YMZ3"/>
    <dbReference type="GeneID" id="9671279"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_35839"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_35839"/>
    <dbReference type="eggNOG" id="ENOG502SIZE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013935_0_0_1"/>
    <dbReference type="InParanoid" id="C7YMZ3"/>
    <dbReference type="OMA" id="CESIRCD"/>
    <dbReference type="OrthoDB" id="3549294at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU47533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="473" mass="52767" checksum="D12CB452FEF2A269" modified="2009-10-13" version="1">MATDPLRLDEEEYRVVYENGYKTWSALMEEASDDPGLPPASLQVEHLFPEHPYFPVGLELDDSGLLTASSTWVPGTGSCDLSSFEQPFQILPYVATPTRLFMSTKAPVPPSAWFQQYDNHLTVLVLAWAYALSARWADIIPQASPLEYTDSQAEWVASQSYDKRTRPRINTSTSATPEEPIWGRDLRQFDRLLTLSCNAHGVKSILGSIFYEPGILCNASGPWLQGTLAVLQSRKAGDLDILARMFSLRSPHLSFLWLGAIIAGLHRGFLKSLGGLLGLNRIDLHEAAWTGTVLSFVQNPVPQQQERATSISRQDEFTLAFLTQGISRYGFPPIYPYPPPGSTTIDDLDLDVRLHTACPGGHGLKFSKITWIRPRPTSSSMTTVIPVDYTQLDPDRDISEISTRNIFMWMREMDGFPINEREIYQHEWFGDDDSDDDERNRPEGDVGSSMGCNLAVTVGGWVSGVMVARCNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C7YN73</accession>
    <name>C7YN73_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_78129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053288.1">
        <property type="nucleotide sequence ID" value="XM_003053242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YN73"/>
    <dbReference type="GeneID" id="9664354"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78129"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78129"/>
    <dbReference type="HOGENOM" id="CLU_1896772_0_0_1"/>
    <dbReference type="InParanoid" id="C7YN73"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU47575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="134" mass="14774" checksum="21383EEDD1D15CDE" modified="2009-10-13" version="1">MSSRQDGLPLSTEVSHAVSTHRHRRSSGDAAVRAVSTRSAPAGTADNTHHHTLTTKHADHTSETKRQINKLPSVSAEDRERRAAEFRMRLKAAVEERKKMTPEERDATSWGGVPLSQTSPEDAFAMLYETIGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNG1</accession>
    <name>C7YNG1_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_78218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053334.1">
        <property type="nucleotide sequence ID" value="XM_003053288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNG1"/>
    <dbReference type="GeneID" id="9664400"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78218"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78218"/>
    <dbReference type="eggNOG" id="ENOG502R9JX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_946956_0_0_1"/>
    <dbReference type="InParanoid" id="C7YNG1"/>
    <dbReference type="OrthoDB" id="1896086at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU47621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="294" mass="32727" checksum="2B11F8AA1DB963B8" modified="2009-10-13" version="1">MSASSTDSRYASRIHIKVCSTPLERLDTAYISYASPRVSHSITFRLAGGTLPWLLFLLIPSSTANMNHASGMATEQGKDLYRVFPKQDTDTAATTQFIKSTVNNQDLLPLTNVRGRLMSWTVEAEPSQVAQLEEHDGIDRVAKLKSPKKDDPLHRKFTIYPVDGQNLDQYNATDASIKALLDDMVKEPRIRDSTFRSWVALLTNAQVEQVEAIDGVKAVHPVYKGRRGVIRRLRKPSSSPKASSLLERRDIIYETQQEAAPELVAASQQSKTLDGGHARGEGYVYHVETDVAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNI9</accession>
    <name>C7YNI9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutathione synthetase</fullName>
            <shortName evidence="10">GSH-S</shortName>
            <ecNumber evidence="10">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_68613</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10 12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="10"/>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052289.1">
        <property type="nucleotide sequence ID" value="XM_003052243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNI9"/>
    <dbReference type="FunCoup" id="C7YNI9">
        <property type="interactions" value="958"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YNI9"/>
    <dbReference type="GeneID" id="9672833"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_68613"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_68613"/>
    <dbReference type="eggNOG" id="KOG0021">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025152_2_1_1"/>
    <dbReference type="InParanoid" id="C7YNI9"/>
    <dbReference type="OMA" id="NGLVMYP"/>
    <dbReference type="OrthoDB" id="2020073at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.50:FF:000002">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1760:FF:000001">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 10 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="13">
        <location>
            <begin position="199"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="412"/>
            <end position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU46576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="489" mass="53956" checksum="27430BEFCDD15A44" modified="2009-10-13" version="1">MASLTSGAYPPTLKAEEKEALVETVKDWSIGNGLAVRPPPTVIAAEADPKGIAAVNVPVTLFPSPFPKQCFAQGKAVQKTYNELYASVSRDEEFLAQVVKEVADGDEFIRNLWDVHLKVKAEGYTQASLILGHFYFFLTYQSLSSDITRYLATTEYPLLDNAIPQGSLDLPDNTSTRGLAAGIEAAYNAYPKSELGHQTCVIFLVQDGERNIFDQRHLEYQVISSSPSTPIFRLPYSQILKHTEIAKTPKRQLLYRLPRNPSKVYEVAVIYMRSGYGPSDYPDQQAWEARYHLERSNAIKCPTVLTQLAGTKKVQQILATPRPASAPSALSRFIRDDTDAAAELWRTFTNIYPMDTSDAGLEARKKALDPEACQAYVLKPQREGGGNNIYRGSIPGFLKSIPESHWNSYILMELITPPPVSNIILRNGSLEQGGVICELGIYGTCVWDQSSGKIQHNEEAGYLLRTKGDKSEEGGVAAGFGCMDSCTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNV9</accession>
    <name>C7YNV9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Exportin-T</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Exportin(tRNA)</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA exportin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_100240</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <text evidence="11">Shuttles between the nucleus and the cytoplasm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052357.1">
        <property type="nucleotide sequence ID" value="XM_003052311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNV9"/>
    <dbReference type="FunCoup" id="C7YNV9">
        <property type="interactions" value="1045"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YNV9"/>
    <dbReference type="GeneID" id="9670879"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100240"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100240"/>
    <dbReference type="eggNOG" id="KOG2021">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004414_0_1_1"/>
    <dbReference type="InParanoid" id="C7YNV9"/>
    <dbReference type="OMA" id="HEMFLFG"/>
    <dbReference type="OrthoDB" id="26399at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071528">
        <property type="term" value="P:tRNA re-export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000355">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045546">
        <property type="entry name" value="Exportin-T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040017">
        <property type="entry name" value="XPOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952:SF11">
        <property type="entry name" value="EXPORTIN-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952">
        <property type="entry name" value="EXPORTIN-T/LOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19282">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="6 11" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="12">
        <location>
            <begin position="105"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-T C-terminal" evidence="13">
        <location>
            <begin position="338"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU46644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1023" mass="114528" checksum="9F916EF60AB824E4" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7YP90</accession>
    <name>C7YP90_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_78676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051969.1">
        <property type="nucleotide sequence ID" value="XM_003051923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YP90"/>
    <dbReference type="GeneID" id="9673122"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78676"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78676"/>
    <dbReference type="eggNOG" id="ENOG502RJ9U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1001329_0_0_1"/>
    <dbReference type="InParanoid" id="C7YP90"/>
    <dbReference type="OMA" id="PSYHVHQ"/>
    <dbReference type="OrthoDB" id="5080588at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU46256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="274" mass="31030" checksum="85750F6FBC2A2869" modified="2009-10-13" version="1">MASKTTFNNDEPLASIDFPGPYAATFYFNNDLAEEPDYLLSSDGGYLTDESDTSEEEEELPPESYMSEFPVVEDNPWPALSPSSTPSLTSSMQTQISSSDLEHSPKDQTDTSELSFTHVGSASSEIEVNTDGYVPFVEPSEGVVDDRTNQTFGASKAQSTTEKRSPAHFINFVDWKNPVPFEDFAKLSPQHRSEIRAIHWDSRLWFSTMFERGTPKYYQELARWRAARLRNIAGVPMDQKQADEIGYIMFRVSEIAAARERERRRRERQAAGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPM1</accession>
    <name>C7YPM1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Plasma membrane iron permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_92545</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051584.1">
        <property type="nucleotide sequence ID" value="XM_003051538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YPM1"/>
    <dbReference type="FunCoup" id="C7YPM1">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YPM1"/>
    <dbReference type="GeneID" id="9673261"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_92545"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_92545"/>
    <dbReference type="eggNOG" id="ENOG502QQWE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046738_0_1_1"/>
    <dbReference type="InParanoid" id="C7YPM1"/>
    <dbReference type="OMA" id="TSMQIFL"/>
    <dbReference type="OrthoDB" id="4364at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="IRON TRANSPORTER FTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632:SF2">
        <property type="entry name" value="PLASMA MEMBRANE IRON PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0410">Iron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU45871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="37488" checksum="DB7D954FDEA77C60" modified="2009-10-13" version="1">MAVDVFAVPVFLVIFRETLETVIIVSVLLAFLKQTLDGPNGDIKVYKQLRRQVWLGTGIGFFICMIVAAALIGVFYTVGSNSWAKNEYYYEGAFSLFAAIIISIMGAALLRVGKMQAKWRVKLAKALESPLKAGSKGWFKKSLEKYAMFVLPFITVLREGIEAVVFVAGVSFSASANADCFRGGSSTKLQLFLVASTCLLYLVGAGLFSRSVWAFELAKWNEYIGGEADEFGNGPGSYDIDQSVWHVNCCASTDTIQNGWSIFNAILGWTNSATYGSVISYNLYWICVMIGFIIMRFHETHGRWPLMKAKAPAAAVNDTESHDSSTVPKNIPTEKTTTVGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQ02</accession>
    <name>C7YQ02_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cellulose-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_38358</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052095.1">
        <property type="nucleotide sequence ID" value="XM_003052049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQ02"/>
    <dbReference type="GeneID" id="9668882"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_38358"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_38358"/>
    <dbReference type="eggNOG" id="ENOG502QXBB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029266_0_0_1"/>
    <dbReference type="InParanoid" id="C7YQ02"/>
    <dbReference type="OMA" id="WIRNNFP"/>
    <dbReference type="OrthoDB" id="3592035at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048527">
        <property type="entry name" value="Sde182_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011483">
        <property type="entry name" value="Sde182_NH-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21027">
        <property type="entry name" value="Sde0182_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07632">
        <property type="entry name" value="Sde182_NH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cellulose-binding Sde182 nucleoside hydrolase-like" evidence="1">
        <location>
            <begin position="16"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Cellulose-binding Sde182 C-terminal" evidence="2">
        <location>
            <begin position="374"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU46382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="55148" checksum="554B73BD997EA44B" modified="2009-10-13" version="1">MATDTAKLQFFPSKPRVFIVSDISNEPDDAESLVRYLLYSNQFNTEGLVACTSTWMKTKVCPQDMHKIVDAYAGAVDNLNKHAHPDFQYPTAEYLKSIIKPGPPVYGFKAIGHDIPLSEGSELLLERVKAPSQDPLWILVWGGTNVLAQVLFKLKHSIPEAEFAAIRSRLRVYTISDQDDTGAWIRNTFPDIFYISSVHAWNQYGMAAWTGISGDEFYGFDQGGPDFSKLTKEWFKENVQIGPLGSAYPNYMFIPEGDTPTFLYLIQNGLGVSEHPEYGSWGGRYLLTDISEAGLGSKHYSDACDKVVGKDGKLYQSNHATIWRWRDAYQNDFAARIQWTLSPSLSSANHHPIITLNGSSGTSPIYISAEAGSTITLDATGTYDPDGDKLTYKWWQYRDPSASQWATFFEVDGTKIENKDGNDKIVDVTLPPPEQCCVELLSRAAIAKGQVLHIILEVTDSGTPSLTSYRRVIIQTTNKDLKGGQAPREAIGDVVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQ27</accession>
    <name>C7YQ27_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">N-glycosylase/DNA lyase</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NECHADRAFT_5326</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-1 OGG1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051664.1">
        <property type="nucleotide sequence ID" value="XM_003051618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQ27"/>
    <dbReference type="FunCoup" id="C7YQ27">
        <property type="interactions" value="607"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YQ27"/>
    <dbReference type="GeneID" id="9673412"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_5326"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_5326"/>
    <dbReference type="eggNOG" id="KOG2875">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027543_1_1_1"/>
    <dbReference type="InParanoid" id="C7YQ27"/>
    <dbReference type="OMA" id="GYAQEYL"/>
    <dbReference type="OrthoDB" id="238681at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000006">
        <property type="entry name" value="N-glycosylase/DNA lyase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000005">
        <property type="entry name" value="N-glycosylase/DNA lyase OGG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052054">
        <property type="entry name" value="Oxidative_DNA_repair_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242">
        <property type="entry name" value="8-OXOGUANINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242:SF2">
        <property type="entry name" value="N-GLYCOSYLASE_DNA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="14">
        <location>
            <begin position="123"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU45951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="362" mass="41586" checksum="5866C82ECAA80B6B" modified="2009-10-13" version="1" fragment="single">WRKLPVSLAELCINTTLRCGQSFRWRKIDHEWTCTLHGRILHLKQDSTHLHYRVTWPAVKSQASPKDDTEALLRHYFSLKLDLGTLYEQWSEADPNFRKRAPQFKGVRILSQDAWEALICFICSSNNNISRISQMVHKLCQHYGPLIGHVGDEAFHDFPTPHDLTGDRVEAHLRELGFGYRAKYIAETARMVAKEKPDNWLETLRNPAHPGFNTPRVPDEQHATYKEAQEQLLSLKGVGPKVADCVCLMGLGWGESVPVDTHVWQIAQRDYKFAKSKAKTFNKTMYDAVGDHFRALWGDYAGWAHSVLFTADLKEFSSQAVKKEEASVVKIEEVSVEEKVTKRKRQRVSVTETETKVKKEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQ49</accession>
    <name>C7YQ49_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibroin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_100038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051674.1">
        <property type="nucleotide sequence ID" value="XM_003051628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQ49"/>
    <dbReference type="GeneID" id="9668903"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100038"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100038"/>
    <dbReference type="eggNOG" id="ENOG502SAKR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022094_0_0_1"/>
    <dbReference type="InParanoid" id="C7YQ49"/>
    <dbReference type="OMA" id="CLCCGIQ"/>
    <dbReference type="OrthoDB" id="5401332at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037504">
        <property type="entry name" value="PSI_induc_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40018">
        <property type="entry name" value="[PSI+] INDUCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40018:SF1">
        <property type="entry name" value="[PSI+] INDUCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU45961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="43560" checksum="8E5FD4D5956FFC13" modified="2009-10-13" version="1">MPSIDEAMARSLRASDWEIVKDKVIRSLAAGLVRRQEVGNAAVADAAQKVDDFATAFSSWDNCMTVPWCNCFQCLQCCGNCCGACDPPGGRKIKHLDDPYAPQNQHHGYRSEPPMNPSTMNSTAPQFAPAPKSSHSEPPQYAEFEMSKPRNDDALPEMPSWDEASNKKVMVHEEAVELDSLAKKPATGQQVGVMNNGSGRLDPYSQPTNNSNGYLAHNQAQDAYSPIDHQAYNYNSIGGNGYSDQAFEAPTGNERYGQGQGYGQMQGYGQSSVQNDHANYGGYRGGPSPAPQGFGARQAPQDDFNGYRQSPAPQNDYAYAQPARQSPAPQHDYGYGQQSHTPAPETHYGSHPVPQRQYPQEPQSPINNNSGFDFNSGFARPQRSPTYEAYPGAKPYQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQR7</accession>
    <name>C7YQR7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_92811</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051781.1">
        <property type="nucleotide sequence ID" value="XM_003051735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQR7"/>
    <dbReference type="GeneID" id="9673610"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_92811"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_92811"/>
    <dbReference type="eggNOG" id="ENOG502SUTB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056204_0_0_1"/>
    <dbReference type="InParanoid" id="C7YQR7"/>
    <dbReference type="OMA" id="ITRSMYC"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF5">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU46068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="359" mass="40328" checksum="4C29FD751786B4A9" modified="2009-10-13" version="1">MADESLRDALSQSPTEADANHDTQSRPSAVKKKVVRRDPAKRRLQNRLAQKTYREKQRKRIQELERRAGEPGFEAHAGPLPGPSDTQMVVRAAAEPTTNAGTLNAETVNPSQLQAGSGTSTSQSTEDIWGQDLLSATLDQWLSENPIGVDENQYSMVYFNCGCPILHIPNHSSHILLPVIPDPYMNTLRIDIICVVSAMLQNCLQLGITHAMYCSDDAISPFYRPHTDAEPGEGAVVSAVQRGFRALHFDLRPTHKQIVIEHHPFLDVIPFKEIRDNIIDNMDTMDEDEFFHDSLNHLTCWGSIAGAHTGSPWDARSWEATEMFLQKWSHIVGGEDGELTRNSRWWRSLRGERVVTEVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7YS03</accession>
    <name>C7YS03_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-lysine N-methyltransferase EFM6</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Elongation factor methyltransferase 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">EFM6</name>
        <name evidence="3" type="ORF">NECHADRAFT_40943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family. EFM6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050873.1">
        <property type="nucleotide sequence ID" value="XM_003050827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YS03"/>
    <dbReference type="FunCoup" id="C7YS03">
        <property type="interactions" value="412"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YS03"/>
    <dbReference type="GeneID" id="9668039"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_40943"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_40943"/>
    <dbReference type="eggNOG" id="KOG2793">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055721_2_1_1"/>
    <dbReference type="InParanoid" id="C7YS03"/>
    <dbReference type="OMA" id="RRADMRF"/>
    <dbReference type="OrthoDB" id="407325at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03198">
        <property type="entry name" value="Methyltr_EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033684">
        <property type="entry name" value="EFM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF152">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="233"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="85"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU45160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="265" mass="29372" checksum="62C7C866730D7759" modified="2009-10-13" version="1">MSSPPSSPLMDPVAISEDLTPLPTLKEIGVAQVDFDGVLSQSLKLREDVRSGCGGQTWPAGMLLGKHMLRYHRDRLNNARILELGAGGGLVGLAVALECDLQNPLLLTDQTEMFELMQHNIKLNGLQSKAKAMVLNWGEPLPATVLEQKPDVILAGECVYFEPAFPLLMSTLKTLLELNPSAVVYFCFKKRRRADMNFVKMAKKAFKVEEIFDEERPVFQRQGLFLFSFTRRTGQQQGQQKAASKSQGETRLAMNGDSQAKDVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSR2</accession>
    <name>C7YSR2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyrimidine 5'-nucleotidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_41339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051400.1">
        <property type="nucleotide sequence ID" value="XM_003051354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSR2"/>
    <dbReference type="FunCoup" id="C7YSR2">
        <property type="interactions" value="574"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YSR2"/>
    <dbReference type="GeneID" id="9666319"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_41339"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_41339"/>
    <dbReference type="eggNOG" id="KOG3109">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059493_0_0_1"/>
    <dbReference type="InParanoid" id="C7YSR2"/>
    <dbReference type="OMA" id="RHHTIDP"/>
    <dbReference type="OrthoDB" id="1065058at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010237">
        <property type="entry name" value="Pyr-5-nucltdase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052791">
        <property type="entry name" value="SSM1_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01993">
        <property type="entry name" value="Pyr-5-nucltdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438:SF1">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU45687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22668" checksum="07E49B1FB28368FD" modified="2009-10-13" version="1">MNAYFEKHLSLPKDEAARLQREYSRQYGQALQGLVRHHQIDPLDYNAQVDDALPLEDLIKPDPRLRQFLQSIDTSKVKLWLLTNAYVNHASRVIRLLGVDDLFEGLTYCDYGQVPLVCKPHEDMFRKAMKEAGVSDVGNCYFIDDSYSNCSGARKAGWTALQYLEKGLPEPSEPAGHYCIRNLEELQDALPQFFKTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7YU02</accession>
    <name>C7YU02_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CSI2 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_101608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050042.1">
        <property type="nucleotide sequence ID" value="XM_003049996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YU02"/>
    <dbReference type="FunCoup" id="C7YU02">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="GeneID" id="9665402"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101608"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101608"/>
    <dbReference type="eggNOG" id="ENOG502S625">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037244_1_0_1"/>
    <dbReference type="InParanoid" id="C7YU02"/>
    <dbReference type="OMA" id="ANAPYMQ"/>
    <dbReference type="OrthoDB" id="4065319at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051009">
        <property type="entry name" value="PRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36089">
        <property type="entry name" value="CHITIN SYNTHASE 3 COMPLEX PROTEIN CSI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36089:SF1">
        <property type="entry name" value="CHITIN SYNTHASE 3 COMPLEX PROTEIN CSI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU44329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="43329" checksum="5749E652C96FFA8E" modified="2009-10-13" version="1">MRPANYLPRPELLLSAFTSVSIFGAMVMAQDDKDKESAAGASGAAAAPAATNTNDDKNSEASKASATAAESAKESNTDNKSEDNKSEAESKTEEKEPASTKEESKPTATKASSTEDKEEPSSTEKEDPTSTEDDPTSTIQSKITSIKSISDSVETGLPTLTKVKAIPTYPAATVPPTSNAPFMQHSSAPDGTVFIAVGAILGALGAAILLWRLIVGILLHRSVERAAKAQHDANAKQGFPAPPAPFYKYTDTGSTMSLSAGRGVRRTTRGPVLSSTPSASNLFFSPTAAATGNGGAGNRGSAFLPSGFYAAGTSSPGGSHEHSISLTNLRPDSRGQFGNPSRHTLNITPPESPAVNPRRDISNSSLNLNRPPSQRAPSAFLDDLLADDPSSLPPPQMPASSGRHSSYGSGSPGGMNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7YU58</accession>
    <name>C7YU58_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_48520</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050456.1">
        <property type="nucleotide sequence ID" value="XM_003050410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YU58"/>
    <dbReference type="FunCoup" id="C7YU58">
        <property type="interactions" value="789"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YU58"/>
    <dbReference type="GeneID" id="9674856"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_48520"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_48520"/>
    <dbReference type="eggNOG" id="KOG0600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="InParanoid" id="C7YU58"/>
    <dbReference type="OMA" id="FPHCDES"/>
    <dbReference type="OrthoDB" id="204883at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070692">
        <property type="term" value="C:CTDK-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045903">
        <property type="term" value="P:positive regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07840">
        <property type="entry name" value="STKc_CDK9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000440">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000270">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF546">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="25"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU44743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="322" mass="36761" checksum="9E22ADC2C3A72785" modified="2009-10-13" version="1">MKRPKPRPTLPADLADSDSVFFRKPGNESVIGSGTYGKVFKGLNVYTKNLVALKRIRMEGERDGFPVTAVREIKLLQSLRHVNIVALQEVMVEKNDCFMVFEYLSHDLTGLLNHPSFKLDAAQKKHLAKQMFEGLDYLHTRGVLHRDIKAANILVSNEGILKIADFGLARFYAKRHQLDYTNRVITIWYRSPELLLGETKYTAAVDVWSAACVMVEIFARHAIFTGDGTELSQLEKIYNILGTPTLQDWPNLVDMAWFELLRPTAKRKNVFGDKYRDKVTPAAFELLSAMFQYDPAKRPSASEVLQHPYFTKEEPQPRQAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7YUD0</accession>
    <name>C7YUD0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2Fe-2S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_63670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adrenodoxin/putidaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050102.1">
        <property type="nucleotide sequence ID" value="XM_003050056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YUD0"/>
    <dbReference type="FunCoup" id="C7YUD0">
        <property type="interactions" value="467"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YUD0"/>
    <dbReference type="GeneID" id="9665545"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_63670"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_63670"/>
    <dbReference type="eggNOG" id="KOG3309">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082632_0_1_1"/>
    <dbReference type="InParanoid" id="C7YUD0"/>
    <dbReference type="OMA" id="TLGWGWR"/>
    <dbReference type="OrthoDB" id="268593at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018298">
        <property type="entry name" value="Adrenodoxin_Fe-S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426:SF65">
        <property type="entry name" value="FERREDOXIN-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="FERREDOXIN/ADRENODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00814">
        <property type="entry name" value="ADX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="7">
        <location>
            <begin position="78"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU44389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="190" mass="20938" checksum="B4A93470A7D391DD" modified="2009-10-13" version="1">MSASRSFATSLAKLSATACRRTQPFLSRGSILSQTSSRSRSAIIPRAARFSPVSQRAFTTSAQRRHGHVEPPKPGEELWITFIEKDGQEHKIAVCEGDNLLDIAQAHDLEMEGACGGSCACSTCHVIVLEDEYFDKMPEPEDDENDMLDLAFGLTETSRLGCQVLMTKELDGLRVKLPSMTRNLQASDFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7YUL4</accession>
    <name>C7YUL4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_84962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050539.1">
        <property type="nucleotide sequence ID" value="XM_003050493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YUL4"/>
    <dbReference type="GeneID" id="9674929"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84962"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84962"/>
    <dbReference type="eggNOG" id="ENOG502RMVK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1304920_0_0_1"/>
    <dbReference type="InParanoid" id="C7YUL4"/>
    <dbReference type="OrthoDB" id="5078661at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU44826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="226" mass="26256" checksum="6A824CD71CF65425" modified="2009-10-13" version="1">MDSASLAHFRDSQLYKDLEQGLRNLVLRKITTNPSAPNSAQDPKIQFYIYGLPERHRYACWCTDNPKWACKRGTSCPQQPRPVLGQNMCLGVCERRHNNGYHCDDRDCFNPRTEVTTYLRTILKPRPSFSRPAWRDRVGSQVGTFNISPNMYHKFVDAVCLLMADLHDPFTAGNKGWNAHVHGIIGWYGRPVERNVEELMHETIKAQTERLEKEYMKAKIRAYNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVH3</accession>
    <name>C7YVH3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_85276</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050301.1">
        <property type="nucleotide sequence ID" value="XM_003050255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVH3"/>
    <dbReference type="STRING" id="660122.C7YVH3"/>
    <dbReference type="GeneID" id="9674721"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85276"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85276"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_11_0_1"/>
    <dbReference type="InParanoid" id="C7YVH3"/>
    <dbReference type="OMA" id="WAIIYQL"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF15">
        <property type="entry name" value="ALPHA-GLUCOSIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU44588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="508" mass="56906" checksum="9D283D746CE86A06" modified="2009-10-13" version="1">MTLIHGVDYSVVDPANKWKILKSQSRFALWERNFGILQPDGSHLIPAHYLSAWNSIAPATEIVSTFIFAPLLDRFGRKWGILAASIISVAGVLLQQLAPDWRMHLAGRGVNGIAIGMMFTISPLWIGETCRPELRGFFLCFFNTSIVFGQFAIVIVSQGSSHISGLWQWWLPVVAMYFFPPWPFFPESPYWLVRRGRNADAKKALRRIYGFKENEYYDIEVCRIEDEIRLTNERHGNLDDLPPRRLLGVNVQLEAECFNTANRKRTFTAIFAASAQQMIGATFVIGYATYFFELIGIKDYFGASVALYVVMLLASTAAFPLTEIYGRRFLIVGPQFMLCLMLLIIGVLGCVPNKSQASWGIVALLYVWALIYQLSIGATGFVLASEIATMRLRAATQGLITITNSLWGLIMQFTVPYMINPDAGDLGGKVGFIFLATGLIAGVGGWYLFPETKGLSFERLDELYAMNVPPRHFKRTVALLEDERSRADPTHTLRSVLAKEGEVSVEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVN3</accession>
    <name>C7YVN3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_74018</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049741.1">
        <property type="nucleotide sequence ID" value="XM_003049695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVN3"/>
    <dbReference type="GeneID" id="9677473"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74018"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74018"/>
    <dbReference type="eggNOG" id="ENOG502SI3E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006329_9_4_1"/>
    <dbReference type="InParanoid" id="C7YVN3"/>
    <dbReference type="OMA" id="WIYFHAS"/>
    <dbReference type="OrthoDB" id="5121955at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052761">
        <property type="entry name" value="Fungal_Detox/Toxin_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425:SF2">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="133"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="177"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU44028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="975" mass="109470" checksum="4C603F8C823E4A09" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7YX94</accession>
    <name>C7YX94_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_82936</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049262.1">
        <property type="nucleotide sequence ID" value="XM_003049216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YX94"/>
    <dbReference type="GeneID" id="9666244"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82936"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82936"/>
    <dbReference type="HOGENOM" id="CLU_420385_0_0_1"/>
    <dbReference type="InParanoid" id="C7YX94"/>
    <dbReference type="OrthoDB" id="5093228at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988636" evidence="3">
        <location>
            <begin position="23"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="310"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="554"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="332"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="369"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU43549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="652" mass="73028" checksum="F2BA7E5EB04035A3" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXL0</accession>
    <name>C7YXL0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 14">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NECHADRAFT_82566</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 14"/>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049317.1">
        <property type="nucleotide sequence ID" value="XM_003049271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXL0"/>
    <dbReference type="STRING" id="660122.C7YXL0"/>
    <dbReference type="GeneID" id="9676968"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82566"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82566"/>
    <dbReference type="eggNOG" id="KOG3187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034302_6_1_1"/>
    <dbReference type="InParanoid" id="C7YXL0"/>
    <dbReference type="OMA" id="SEWWLMY"/>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF3">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU43604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="216" mass="24242" checksum="3902CA2B33A2F858" modified="2009-10-13" version="1">MARPTSQTQPRRVSSAYLCIYNLLSALLRICILLSTAYLWSTSGNVAVWGKLSDTARWSETLTALEVLHALTGLVRAPPATTALQVAGRNTIVWAITRNYPDVAAGESAYSYMLMAWNLADSVRYLYFAFQTGTSSVPSILLWARYNLFIFLYPIGILSEARLVYKVIEPSKARNSSYQYLLWFGLAIYVPAFYILYGHMLAQRAKVSRSSRAKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7YY91</accession>
    <name>C7YY91_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-1,2-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_47137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU42965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048678.1">
        <property type="nucleotide sequence ID" value="XM_003048632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YY91"/>
    <dbReference type="STRING" id="660122.C7YY91"/>
    <dbReference type="GeneID" id="9665782"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_47137"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_47137"/>
    <dbReference type="eggNOG" id="KOG2515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025462_0_2_1"/>
    <dbReference type="InParanoid" id="C7YY91"/>
    <dbReference type="OMA" id="TMGIRNM"/>
    <dbReference type="OrthoDB" id="497541at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="45837" checksum="34AA0918E3FED013" modified="2009-10-13" version="1">MVLSLSSFGAHEAIVVLSILTGISFVAYQIFNIFSTRKSKLNNDLPPLSAGWEPSDYKTPIPEPYPGWSIEKTKPLPYRAFRYGPKYQVTMGLRTVSSEEWIELDSDYPKYHADKKARIEERGEKCVATHPDAYPAAIELLQELTEYLPSRYPTLFERTPVGIKNKWSGEDFNIVERPLAEDPMAICARLVQDDLALMIERPDGQYYLLAGAVLLAGFWRLSDKYGMSLSDIHYSGDVPHFKEKLETGMCKFFKRLKCESVYCRNNYFLQVDDALAWSWSIGGEDDPVVSWSTAQKDKAIEHHMFRSERQSLRRLPKTGAIVFTIRTYFHPVTDIVKEDYVPGRLASAVRSWDDKVSNYKGKEKYGGVLLEYLDREHEKQLARGLNLEKEDEVRKYPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYR8</accession>
    <name>C7YYR8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PH-response regulator protein palH/RIM21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_47031</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the palH/RIM21 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048953.1">
        <property type="nucleotide sequence ID" value="XM_003048907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYR8"/>
    <dbReference type="STRING" id="660122.C7YYR8"/>
    <dbReference type="GeneID" id="9665950"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_47031"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_47031"/>
    <dbReference type="eggNOG" id="ENOG502QWMT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014594_1_0_1"/>
    <dbReference type="InParanoid" id="C7YYR8"/>
    <dbReference type="OMA" id="AWVVYYA"/>
    <dbReference type="OrthoDB" id="5393256at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014844">
        <property type="entry name" value="PalH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35779">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALH/RIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35779:SF1">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALH_RIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08733">
        <property type="entry name" value="PalH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988804" description="PH-response regulator protein palH/RIM21" evidence="8">
        <location>
            <begin position="21"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="399"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="442"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="498"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="586"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="634"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="670"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="447"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="502"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="602"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="674"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="741"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="753"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU43240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="775" mass="84559" checksum="1CE17F06AE1683B1" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZ27</accession>
    <name>C7YZ27_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_71194</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049006.1">
        <property type="nucleotide sequence ID" value="XM_003048960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZ27"/>
    <dbReference type="SMR" id="C7YZ27"/>
    <dbReference type="FunCoup" id="C7YZ27">
        <property type="interactions" value="768"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YZ27"/>
    <dbReference type="GeneID" id="9666078"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_71194"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_71194"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025000_1_2_1"/>
    <dbReference type="InParanoid" id="C7YZ27"/>
    <dbReference type="OMA" id="NEIRVNW"/>
    <dbReference type="OrthoDB" id="8093034at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12614">
        <property type="entry name" value="RRM1_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12619">
        <property type="entry name" value="RRM2_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000117">
        <property type="entry name" value="Nuclear and cytoplasmic polyadenylated RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000224">
        <property type="entry name" value="Nuclear and cytoplasmic polyadenylated RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000134">
        <property type="entry name" value="Nuclear and cytoplasmic polyadenylated rna-binding pub1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF5">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="84"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="174"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="300"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="410"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU43293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="474" mass="51132" checksum="412678EA76226073" modified="2009-10-13" version="1">MADAGTPSNTAQLPPPPEPNAGAQGFQGGQNGSQALPPPPLHIPQNTNPIPTAITSPRSGDQGGIMSPTSAGGFRRAAPEPNKRALYVGGLDQRVTEDVLRQIFETTGHVQNVKIIPDKNARGYNYGFVEYDDPGAAERAMQTLNGRRVHQSEIRVNWAYQSNTSNKEDTSNHFHIFVGDLSNEVNDEVLLQAFSAFGSVSEARVMWDMKTGRSRGYGFVAFRDRPDAEKALSSMDGEWLGSRAIRCNWANQKGQPSMAQQQAMQAMGMTPTTPYGHHQFPAHGVASYEVILTQTPSWQTTCYVGNLTPYTTPNDVVPLFQNFGFVVESRFQADRGFAFIKMDTHENAAMAICQMNGYNVNGRPLKCSWGKDKTPNAQGGFDPAQPYSPQSAQAPGYPGTPTFYPQYGAQYGGQPGNYGGPQTGSPAGYGGSPMGYAGPQSAGGYGRGQQPPNAEWAQPRPGQNFNNGFGGYQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZ52</accession>
    <name>C7YZ52_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peroxisomal adenine nucleotide transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_83912</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048830.1">
        <property type="nucleotide sequence ID" value="XM_003048784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZ52"/>
    <dbReference type="STRING" id="660122.C7YZ52"/>
    <dbReference type="GeneID" id="9665678"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83912"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83912"/>
    <dbReference type="eggNOG" id="KOG0769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_6_2_1"/>
    <dbReference type="InParanoid" id="C7YZ52"/>
    <dbReference type="OMA" id="DHGQQKY"/>
    <dbReference type="OrthoDB" id="18574at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF2">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="7"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="102"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU43117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="30024" checksum="85CC7EBD73219889" modified="2009-10-13" version="1">MSSKQALNALGHAVSGSIGTAISTSSLYPLDLITTRLKAQRKTADTTGDYDGIIAAFNGIAANEGGIKALYSGLGTSVAKSVVDSFLFFGFYNYLRRRDRTPKILEELAIGAIAGACARALTTPISNVVTRKQMLGDEQSLKEILTEMRQEGGLLGLWSGYSATLVLTLNPSITFFVNRRLAARIIPALEEEDFPIAWIAFLIAASSKAVATAVTYPFQTGKTRLQMASGSIDLAEQDEKGQEAKSKTERILRRMVEFLDQSIFGGFAPSYSRASSAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZA0</accession>
    <name>C7YZA0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_47731</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048280.1">
        <property type="nucleotide sequence ID" value="XM_003048234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZA0"/>
    <dbReference type="GeneID" id="9667557"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_47731"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_47731"/>
    <dbReference type="eggNOG" id="ENOG502R6NR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024934_7_0_1"/>
    <dbReference type="InParanoid" id="C7YZA0"/>
    <dbReference type="OMA" id="RNCKTRK"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU42567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="509" mass="57444" checksum="5B4A825ED0580F65" modified="2009-10-13" version="1">MDTSTLAPASQEAQTSEQPQSQPLPESATQLGSGDKPYHSKRPHKKSRTGCKNCKKRKVKCDEARPVCRSCRLRKADCVYPHPPASSSSSNNEPPTSPSASSVSSATQRAVSPDIVSISSGDDMVEETGPLVSQPLFRSGQMDTADMKLLWFYTSATSASFSIDDGRFNPVSEILKTRMVQVAFENPFLMDSLFALASLHMQSLNQECDPSRALAYRARSFEGYRRAVEQARPETYPALIANSLLLTALSSQTFRDDDSKELYIIDWMIVWRGIGLVIDLMGVERLFDSGLYALFSRPPIDLEKATGAIPNNLLFMVTSIKADDPDFTDVDTYYETLKYLGSLYHNMNDGISPVMVLRIITWFTFVPRHFIQLARERRPRALVILAYYAAFLKLTKVVWWLENVGDRSLNDLCEYLGPEWQHLLVVPQMARLVDTDMGIARVLFENPNWVPSTPTNLRIDPTAAITFLDDEGRRVEWTPSEKKLVLLDPRKDNTLDEWRNDPKLWKPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z081</accession>
    <name>C7Z081_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ARCA protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_47600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048637.1">
        <property type="nucleotide sequence ID" value="XM_003048591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z081"/>
    <dbReference type="STRING" id="660122.C7Z081"/>
    <dbReference type="GeneID" id="9667714"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_47600"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_47600"/>
    <dbReference type="eggNOG" id="ENOG502SK60">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008719_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z081"/>
    <dbReference type="OMA" id="TIWYSFD"/>
    <dbReference type="OrthoDB" id="4525710at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="415" mass="47215" checksum="BBE688B25440C1CB" modified="2009-10-13" version="1">MSHSNRSIDSQHQAGGSPSYQTPPSWQAGTGRSPPDLTSVSSGYLSNPDHPSPSYGQSHHRGNSNAISPHSQPFHAPGESTTFPLKDPQEACLLRYFVEELSHWVRQLLPKLTPHDAVEYTLKCIPALRDFHVIQDDDRLECILATAVILRQLEEIDDEEEEARSDSQVDENEGPRSKEQVNFLAIIDAVLRSPPSQTLFGRRSLIQAAYWMAVRQELYHSFTKRHPPKMILDPEYGRGASRANKIVLHTAQVAKWRWADGSEQEWLRLQKQGEVLEEEALQEYQPYFVRPADRSNGEIFPTIWYASALEVTSMQLCIIAKMVLMAENPFLGGHSTSRARWREIENEVRQMILDLCGISLCHPACPPALVHAAFGMELYGDFFTDHYERRALRGVVEKFRDARAWPVKKLSNMFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0C4</accession>
    <name>C7Z0C4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_39937</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048068.1">
        <property type="nucleotide sequence ID" value="XM_003048022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0C4"/>
    <dbReference type="STRING" id="660122.C7Z0C4"/>
    <dbReference type="GeneID" id="9667240"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_39937"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_39937"/>
    <dbReference type="eggNOG" id="ENOG502SHK9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019101_2_2_1"/>
    <dbReference type="InParanoid" id="C7Z0C4"/>
    <dbReference type="OMA" id="EHMQMIT"/>
    <dbReference type="OrthoDB" id="3903189at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF30">
        <property type="entry name" value="FAMILY DECARBOXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="22"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="293"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU42355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="401" mass="45136" checksum="D3A95F5F06C53C94" modified="2009-10-13" version="1">MSNLDTEMWAWYALTLVVVLSRMISRRMLLGSWKNMLADDYLMVFTMITYTILLVIVKVLTYTPTNLIQPGEKIDLSDRKDIADREFGSKLVLVTEQMQMFTLWGVKGCLLFMYGRLTLSLRQNFFVKIVAGYVVLGFVVMQILWFAAWCRPFSHYWQVPPQDLNCSAETNHMITNAVMNISSDIMIIALPMPVFLQSQLAIKRKVVLCGVFALGIFTILAAALSKYYSLGDPYGSEWIYWYIREVSTAIITANLPLTWTLLQRVFRLGSFAARYGKSSGQRTGEATSRFRSNYGNLTSVTREERRTRLGTSHEPGLSISESQEQINSGDSIPLKIYQKNEVTVTTNELETGRRVSSPTEQQAGLDRAAFGEEHGSASSTNGDKPASEIELGVVTKAYHGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0P5</accession>
    <name>C7Z0P5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_40414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048130.1">
        <property type="nucleotide sequence ID" value="XM_003048084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0P5"/>
    <dbReference type="FunCoup" id="C7Z0P5">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z0P5"/>
    <dbReference type="GeneID" id="9671937"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_40414"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_40414"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_12_0_1"/>
    <dbReference type="InParanoid" id="C7Z0P5"/>
    <dbReference type="OMA" id="WLEYSQL"/>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="345" mass="37804" checksum="30A31AEBDED881A5" modified="2009-10-13" version="1">MAQRNILVTGATGYVGGSVLTTLLKSESALIQPSSVTALVRKKDQADVLASQGIKTSIFRDLDDSEHLKRVAAEHDVVIHTASGFHLGSALALIEGLGQRKTQNGGKVHYIHTSGTWNLAGLELTNKGGLTEFKEDDLLDHLRKLEEESPFSQRTTLFGVIAAAGQHGVEAHILLPPDIYGQGTGLFNKHTPQLFDLVKKAIGVGYPECIGDGLGGAGHVHVTDLAELYKVMILRILQGEAVPSGKDGLFFTETGYHNWFDVAKLIGEVGVSRGVLKSADPRSITVEEAAQRWEESTNGDQEITKLCFCMRNKTVPNRAYELGWKPEKTDHDWRVWIEEVFRIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z110</accession>
    <name>C7Z110_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_93345</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048196.1">
        <property type="nucleotide sequence ID" value="XM_003048150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z110"/>
    <dbReference type="STRING" id="660122.C7Z110"/>
    <dbReference type="GeneID" id="9667368"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_93345"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_93345"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005646_3_0_1"/>
    <dbReference type="InParanoid" id="C7Z110"/>
    <dbReference type="OMA" id="DENQAIH"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000103">
        <property type="entry name" value="NADPH oxidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000004">
        <property type="entry name" value="NADPH oxidase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF153">
        <property type="entry name" value="SUPEROXIDE-GENERATING NADPH OXIDASE HEAVY CHAIN SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="173"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="278"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU42483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="572" mass="65899" checksum="9707BF854A97E6AA" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z120</accession>
    <name>C7Z120_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_40329</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048005.1">
        <property type="nucleotide sequence ID" value="XM_003047959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z120"/>
    <dbReference type="FunCoup" id="C7Z120">
        <property type="interactions" value="799"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z120"/>
    <dbReference type="GeneID" id="9671990"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_40329"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_40329"/>
    <dbReference type="eggNOG" id="KOG1135">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002227_3_0_1"/>
    <dbReference type="InParanoid" id="C7Z120"/>
    <dbReference type="OMA" id="QSRHNME"/>
    <dbReference type="OrthoDB" id="64353at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025069">
        <property type="entry name" value="Cpsf2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13299">
        <property type="entry name" value="CPSF100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Beta-Casp" evidence="6">
        <location>
            <begin position="287"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="509"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="616"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="830"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="522"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="633"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="837"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU42292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="958" mass="104009" checksum="7FE6E8361E2E9241" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1D5</accession>
    <name>C7Z1D5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">agmatinase</fullName>
            <ecNumber evidence="4">3.5.3.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_104385</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>agmatine + H2O = urea + putrescine</text>
            <dbReference type="Rhea" id="RHEA:13929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="3.5.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="5">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.11" evidence="4"/>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048058.1">
        <property type="nucleotide sequence ID" value="XM_003048012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1D5"/>
    <dbReference type="STRING" id="660122.C7Z1D5"/>
    <dbReference type="GeneID" id="9671868"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_104385"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_104385"/>
    <dbReference type="eggNOG" id="KOG2964">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039478_1_1_1"/>
    <dbReference type="InParanoid" id="C7Z1D5"/>
    <dbReference type="OMA" id="CIDAGFV"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019627">
        <property type="term" value="P:urea metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000006">
        <property type="entry name" value="Agmatinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF30">
        <property type="entry name" value="AGMATINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988417" description="agmatinase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00050304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00066392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036979-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU42345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="395" mass="42660" checksum="B1FEF90C709E7756" modified="2009-10-13" version="1">MFINALLSLGYASVVMAHAGHEQEPISGPHQSLWYSTLPGDGGTQADSVFSGITTFGRLPYQPCLSHSSIKYDIAFIGAPFDTGTSYRPGARFGPSGIRQGSRRLNLYGGYNVPLATNPFNSWATVLDCGDIPVTSYDNTFALQQIEEGHYSILSRAPVTDADKVGPAKKGKTLPRVITLGGDHTITLPLLRSINRAYGPVSVIHFDSHLDTWKPKVFGGSPSDVASINHGTYFYHAAMEGLLANDTNIHAGIRTTLSGPSDYDNDGYCGFEIVEAREIDTIGTDGIIERIVKRVGTERPVYLSIDIDTLDPAFAPATGTPETGGWSTRELRTILRGLESLNLIAADIVEVAPAYDTNAEHTTMAAADVLYEVMSMMVKKGPLSRMIEGKEQSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1W3</accession>
    <name>C7Z1W3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_85937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU41895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047608.1">
        <property type="nucleotide sequence ID" value="XM_003047562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1W3"/>
    <dbReference type="GeneID" id="9671568"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85937"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85937"/>
    <dbReference type="eggNOG" id="KOG3947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041441_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z1W3"/>
    <dbReference type="OMA" id="HIHDGRG"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF16">
        <property type="entry name" value="SER_THR PROTEIN PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G06000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU41895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="371" mass="40801" checksum="D0D263265D957C68" modified="2009-10-13" version="1">MASSTRRRRTRIVCISDTHNCTVKLPKGDVLIHAGDLTNQGSYSELSKTIAWLEKADFEAKIVIAGNHDITLDSDFYAEHGMYFHNNNPQSSEECLGLFASSSITYLHHESATIRLRSPTGPHTEFKIFGSPYSPRHGLWAFYYDAPKNHSNWSDLTSLWELIPLDTDIVVTHTPPRTHCDETDERRATGCEALRQALWRVRPQLAVCGHIHSGRGAERVTWDLSCRNVAYQEESVVRWQDPGQGNKTSLVDLTGKKAPSLANDGSHPGRSGSTAGNVDAMTPSDPITTADSPPYTFGADVEAGHGTLGLGGDSSSPRCDQAALTGRMGRRETCVVNAAIMKSRYPHVGGKQFYKPIVVDLDLPVWDDESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z281</accession>
    <name>C7Z281_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_50901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU41956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047669.1">
        <property type="nucleotide sequence ID" value="XM_003047623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z281"/>
    <dbReference type="GeneID" id="9671625"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_50901"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_50901"/>
    <dbReference type="eggNOG" id="ENOG502SG6V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025630_2_0_1"/>
    <dbReference type="InParanoid" id="C7Z281"/>
    <dbReference type="OMA" id="YHYANSR"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46023:SF6">
        <property type="entry name" value="LIPASE CLASS 3 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46023">
        <property type="entry name" value="LIPASE CLASS 3 PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="2">
        <location>
            <begin position="295"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU41956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="562" mass="62114" checksum="25B678EA30A9CC4F" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z2M1</accession>
    <name>C7Z2M1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_87648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047213.1">
        <property type="nucleotide sequence ID" value="XM_003047167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z2M1"/>
    <dbReference type="GeneID" id="9676055"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87648"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87648"/>
    <dbReference type="eggNOG" id="ENOG502SJSX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047427_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z2M1"/>
    <dbReference type="OMA" id="YYMLEAY"/>
    <dbReference type="OrthoDB" id="3642468at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="49"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU41500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="344" mass="39993" checksum="900798689307FF9C" modified="2009-10-13" version="1">MKPPATDYDSDDEVLIDNTEALTLRSKKTGRQKKKLERKTKKKAAKPHLLSLYPELIIEILTHLRPSDIISYQQTCHSAKAFIEQHNSSIARSIISYRYSVLAKCFPRPVFLDTVDRKYHDVMLTERRQKLLTIHRKPYAHIADHDASVLCSCLTCVLAWNNLCLIADLSHWINSAIAHRKPIPMIPRGQNADWNVELVEKHANVVRRALKSPTWYALLLQRHLQSTIFGIRRYTSKDGEAGFGLDDDDVAAETDDFCARDGPPSYEFPLHRDIYYSLQTYLPNRIWRKEDDEWRYQPADQHFKDLEWMMSLPNKWIAPVAETKADEEEVKQEQPVSQEVINIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z366</accession>
    <name>C7Z366_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RTA1 like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_87845</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047491.1">
        <property type="nucleotide sequence ID" value="XM_003047445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z366"/>
    <dbReference type="GeneID" id="9676236"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87845"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87845"/>
    <dbReference type="eggNOG" id="ENOG502QU4U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033465_6_1_1"/>
    <dbReference type="InParanoid" id="C7Z366"/>
    <dbReference type="OMA" id="SPKMYLW"/>
    <dbReference type="OrthoDB" id="4521223at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF8">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU41778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="37255" checksum="3A5E8998D69B1BC5" modified="2009-10-13" version="1">MSTNSTNSTDVFIPNFKTCDEVNEQCPVEAQMYGDYFTKSACIWFTMLYFMCFGTQMFYAWRSKAWSYAAWLGVGTAFEGMGYAARIVMCDDPWNFYAFLVQNLGLVLAPTFIAAAISIIFKHLIDWYGSEWSLFRPALLPWILVGSDMVSIIVQGTGGAVSSMASNKNGKEAKDLMDVGNGLLLGGTIFQVVNMVACGGIMLLYLWKRQQSLGRFRSRLGSGDPQDSSKSSGGRGQYDFEATLKVYIWSLVVAYNLIIVRCIYRAVEMASGWGSDIMKTEAILITFESQMILTTVAILTIFHPYVFFPVAGRGGIDRARRSVHSDIQELRPMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z480</accession>
    <name>C7Z480_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cyclin-dependent kinase</fullName>
            <ecNumber evidence="1">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_46260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="1"/>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046981.1">
        <property type="nucleotide sequence ID" value="XM_003046935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z480"/>
    <dbReference type="FunCoup" id="C7Z480">
        <property type="interactions" value="207"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z480"/>
    <dbReference type="GeneID" id="9675633"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_46260"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_46260"/>
    <dbReference type="eggNOG" id="KOG0594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_6_1"/>
    <dbReference type="InParanoid" id="C7Z480"/>
    <dbReference type="OMA" id="FELWTVF"/>
    <dbReference type="OrthoDB" id="413582at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF576">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CSK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="89"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU41268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="384" mass="43093" checksum="CA9FAD1D3B41BA02" modified="2009-10-13" version="1">MASVGLPEWKAALSASQRYETIQKIQDSLATTSMSEAIAIEQAAYQISSTQEEYNLACQPTSTPLPRQEAQDYDEAEVEEESGVRIGSYRNCHPISEGVTSEVYRSGDKALKVIVAYQNIEPHNPQREAKILKTLRSPCIELLETFRDQEQQFVLVFPFMPYTLTDLLDKGPIPLDAARSIFGDVLQGLKDIHAQGIIHRDIKPSAILLASPTGPAYLSDFGTVWHPEFSAQSEPHDDKILDIGTGAYRAIDVLFGNKSYGPEVDMWGLGVMISEAIRDPPKPIFESRAVHEDGNQLGLILSIFKTIGTPTPETWPEAKEFKISPFQLWTVFPSRPWDVILPDVDAEFRELVASLVRYDKQRLSAEQVSFLRQFPHAQTNKYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4H5</accession>
    <name>C7Z4H5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_76523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046638.1">
        <property type="nucleotide sequence ID" value="XM_003046592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4H5"/>
    <dbReference type="STRING" id="660122.C7Z4H5"/>
    <dbReference type="GeneID" id="9668423"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76523"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76523"/>
    <dbReference type="HOGENOM" id="CLU_622698_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z4H5"/>
    <dbReference type="OrthoDB" id="5018025at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="18"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU40925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="440" mass="49788" checksum="50D9D26865298479" modified="2009-10-13" version="1">MFLSHQQSGLAKHANHWCPTDLPSNFADVARVCIRLGIPYLWIDSLCIIQDSADDWKREAIKMHLVYRHAVVTIVATSATSTHDGFLERDFKKTLAAKVHYSLEHDQESLPSGYGRDKYMVISCRENYQDSYPTYAINESKWNTRAWTMQERSLSTRLIHFCRNKIFFECRSCIKSEENEPVAHYALMTRILWPRDPSTSLDTLYGFWQWCLTQYCPRNLTKGKDKLIAIQSVAEEMMSTTKNSSFLSEKPRGTMPLVHRAGHGVRWTDTSRSILESCQRGSEAYQSLEVTAWVRPISTVAKAKTVNDVEKFFPFKLVAGASYGRGEDEHVFAHGRLDIDEPGENVRLLYLQMGIVGVAIVVDDEQGFIRSEGLFGNGAVRSKIIMVQALGSSNKAAIPMKNGLLTCGETVDEVGFMFELLERSCEIQLYVEAVEANGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4V8</accession>
    <name>C7Z4V8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Expressed protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_99310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046703.1">
        <property type="nucleotide sequence ID" value="XM_003046657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4V8"/>
    <dbReference type="GeneID" id="9678508"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_99310"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_99310"/>
    <dbReference type="HOGENOM" id="CLU_1267196_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z4V8"/>
    <dbReference type="OrthoDB" id="5101600at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU40990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="218" mass="24096" checksum="075BA02E10BEC52E" modified="2009-10-13" version="1">MSHRSDTHREASRRERSSRGREQAPQHQGHRQPSVSQVLHQQMQQQQQQQYTPSYASSSGYAATGAYASYDTSQGQSGTPDYVTQGYPQAPSTPRAHQGSVPDSQYSPGRADTRVRIGGYQDDPEDSARRTESFVRDGDENRVAASRSSQSRRAHKKKRKDKARSAIDEFDAAYPNAAYDAANPHTNQYTNASGQYNEDPDLDCGNGPNQGGSSYEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z5G9</accession>
    <name>C7Z5G9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ERCC1-like central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_33938</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERCC1/RAD10/SWI10 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU41099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046812.1">
        <property type="nucleotide sequence ID" value="XM_003046766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z5G9"/>
    <dbReference type="STRING" id="660122.C7Z5G9"/>
    <dbReference type="GeneID" id="9678617"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_33938"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_33938"/>
    <dbReference type="eggNOG" id="KOG2841">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041616_1_1_1"/>
    <dbReference type="InParanoid" id="C7Z5G9"/>
    <dbReference type="OMA" id="GTTTCAM"/>
    <dbReference type="OrthoDB" id="10262814at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070522">
        <property type="term" value="C:ERCC4-ERCC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045002">
        <property type="term" value="P:double-strand break repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007534">
        <property type="term" value="P:gene conversion at mating-type locus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22325">
        <property type="entry name" value="ERCC1_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000001">
        <property type="entry name" value="DNA excision repair protein ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047260">
        <property type="entry name" value="ERCC1-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004579">
        <property type="entry name" value="ERCC1/RAD10/SWI10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00597">
        <property type="entry name" value="rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749:SF0">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749">
        <property type="entry name" value="EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03834">
        <property type="entry name" value="Rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC1-like central" evidence="8">
        <location>
            <begin position="59"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU41099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="324" mass="35233" checksum="1D0AD820BB7C9FE4" modified="2009-10-13" version="1">MAAADPTPIPRRPIQQPTPSKIQQPTPQRLDKAPPSASGAGKVVQPTPQALPQKQSGSTILVSPRQRGNPVLTSIRSMPWEYSDIPADFVLGLGTCALFLSLKYHRLHPEYIYTRIRNLQGKYNLRVLLTMVDIPNHEANLKELSKTSLVNNVTLILCWSAAEAARYLELYKSYENASFGAIRGQQPSSYGEKLVEFVTVPRSLNKSDAVALVSNFGSLKNAVNADAEQLGMLNGWGGIKVKRWTSAVGDPFRVKKAAKRGAKATQRLSKLDQADDEEAMLAAAIEASKKTAQSDEAKRASQADKDDQLDGGVAAALARLRESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z5T3</accession>
    <name>C7Z5T3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PLAC8 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_34156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046291.1">
        <property type="nucleotide sequence ID" value="XM_003046245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z5T3"/>
    <dbReference type="STRING" id="660122.C7Z5T3"/>
    <dbReference type="GeneID" id="9678396"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_34156"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_34156"/>
    <dbReference type="eggNOG" id="ENOG502SF2A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083147_2_2_1"/>
    <dbReference type="InParanoid" id="C7Z5T3"/>
    <dbReference type="OMA" id="DCFNPID"/>
    <dbReference type="OrthoDB" id="1045822at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU40578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="19489" checksum="4B0226ACEDD960DF" modified="2009-10-13" version="1">MATPAQNVNNNGPIDHNDLNEWKDRFNDVLARPSEHVNSKSPESSQPWHNAFFGCFAPIDTCLITCCVPCVTFGKTHHRLRKNGNLDGYEPINTSCLMFWGSSCFGLHFIPLALQRANLREKHNLQGSCLVDIATACCCGCCDLIQQDKEAEYREAQASSGQGYKANEGMSYPASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z5V8</accession>
    <name>C7Z5V8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell wall mannoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_33829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046304.1">
        <property type="nucleotide sequence ID" value="XM_003046258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z5V8"/>
    <dbReference type="STRING" id="660122.C7Z5V8"/>
    <dbReference type="GeneID" id="9678409"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_33829"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_33829"/>
    <dbReference type="eggNOG" id="ENOG502QTC3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026014_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z5V8"/>
    <dbReference type="OMA" id="QHNACAR"/>
    <dbReference type="OrthoDB" id="2153847at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053216">
        <property type="entry name" value="Appressorial_penetr-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587:SF1">
        <property type="entry name" value="CIRCUMSPOROZOITE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988959" description="Cell wall mannoprotein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU40591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="514" mass="50590" checksum="C5DFA333FC8865DB" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z5W4</accession>
    <name>C7Z5W4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Caib baif family enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_90636</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046305.1">
        <property type="nucleotide sequence ID" value="XM_003046259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z5W4"/>
    <dbReference type="GeneID" id="9678144"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90636"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90636"/>
    <dbReference type="eggNOG" id="ENOG502QUIE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028036_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z5W4"/>
    <dbReference type="OMA" id="HYGYPGR"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025496">
        <property type="entry name" value="DUF4387"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14330">
        <property type="entry name" value="DUF4387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyclic terpene utilisation N-terminal" evidence="2">
        <location>
            <begin position="158"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4387" evidence="3">
        <location>
            <begin position="542"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="500"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU40592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="668" mass="72507" checksum="41946DF3EF00D954" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z5W8</accession>
    <name>C7Z5W8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-tryptophan decarboxylase PsiD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_34149</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045739.1">
        <property type="nucleotide sequence ID" value="XM_003045693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z5W8"/>
    <dbReference type="STRING" id="660122.C7Z5W8"/>
    <dbReference type="GeneID" id="9678146"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_34149"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_34149"/>
    <dbReference type="eggNOG" id="KOG2419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033450_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z5W8"/>
    <dbReference type="OMA" id="YISHIAT"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022237">
        <property type="entry name" value="PsiD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF9">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G01730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12588">
        <property type="entry name" value="PSDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="L-tryptophan decarboxylase PsiD-like" evidence="3">
        <location>
            <begin position="65"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU40026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="483" mass="54391" checksum="DC249640E003842F" modified="2009-10-13" version="1">MKVDIHSGRLSGAFHAPVPYRRRHPLNPGRSVPGYNAHSFASWTRTFVAYVDQRYRRPEIPSWPQPIQDLSDLIESTPELRMLASAMFDEVPSKQPYLKDPAGHRQIRDYHHMLHLFSIIMTTIAPSWSMSEHGLGIVGFPFNAVLDWPMATRSGYAFFLKAEVNAKLKVILDTWRDNVLKTNKQYVLTTDPDGWLSSSVLVTIEGETNVDGQEPLPFHQIFECDPIGDPVHWGFQCWDDFFVRKFKDMDKIRPVAFPDDPRWIVNACESRPYALQANVKDYDTFWLKGQPYSVVEMLNHHPNASQFVGGTVFQAFLSATAYHRWSSPVAGKVIHSEVIDGTYFSEPTFDGFANPEGPDQAGPDRAQGYISHVATRAMFFIDTEGPAGVVCVLFVGMADVSTCEILERFQRNLPQTVAKGEELGMFHHGGSTYCLLFPPDVNLTWVTAAYPGISDKNIPIRSGLAYACPTASTRRARLRFPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6F9</accession>
    <name>C7Z6F9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_90745</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046399.1">
        <property type="nucleotide sequence ID" value="XM_003046353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6F9"/>
    <dbReference type="GeneID" id="9668672"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90745"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90745"/>
    <dbReference type="eggNOG" id="KOG0754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_5_2_1"/>
    <dbReference type="InParanoid" id="C7Z6F9"/>
    <dbReference type="OMA" id="RDATPTC"/>
    <dbReference type="OrthoDB" id="434783at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051752">
        <property type="entry name" value="Mito_2-oxodicarb_carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356:SF1">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="128"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="223"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU40686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="315" mass="34560" checksum="450A54B4DC56642C" modified="2009-10-13" version="1">MCNGSKKGFVSRTSCCFVRLSAWPQDRLPPPRFRNSCSQVCGVAGISEVSTRCGQDKTTASTEHERNRGLLKHDRLFPQDSKARRCRPLLPRNSSPGLNGDPQEAPTKFTANDSWAKFYADVFNTQRRDQKLAILTGASAGATESIVVVPFELVKIRLQDKSSAARYKGVLDCAVKIVRESGPLGLYQGFESTVWRHIVWNAGYFGCIFQVRSLLPTAEAKKDTMVNDLIAGSVGGTVGTLLNTPFDVVKSRIQSSTGAKETLPWVWSGMIKVYREEGVVALYKGLVPKVVRFAPGGGIMLVVYSFMIDLLTSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6H9</accession>
    <name>C7Z6H9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_76109</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045847.1">
        <property type="nucleotide sequence ID" value="XM_003045801.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9667970"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76109"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76109"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_34_9_1"/>
    <dbReference type="InParanoid" id="C7Z6H9"/>
    <dbReference type="OMA" id="NQACANE"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="373"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="837"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="870"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="905"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU40134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1324" mass="147470" checksum="C09E31FE59F2701F" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z770</accession>
    <name>C7Z770_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF1014 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_33315</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC124 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045963.1">
        <property type="nucleotide sequence ID" value="XM_003045917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z770"/>
    <dbReference type="STRING" id="660122.C7Z770"/>
    <dbReference type="GeneID" id="9668245"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_33315"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_33315"/>
    <dbReference type="eggNOG" id="KOG3223">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069723_1_1_1"/>
    <dbReference type="InParanoid" id="C7Z770"/>
    <dbReference type="OMA" id="FEERMMP"/>
    <dbReference type="OrthoDB" id="76412at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010422">
        <property type="entry name" value="Ccdc124/Oxs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054414">
        <property type="entry name" value="Ccdc124/Oxs1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054413">
        <property type="entry name" value="LSO1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06244">
        <property type="entry name" value="Ccdc124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22048">
        <property type="entry name" value="LSO1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LSO1/LSO2" evidence="5">
        <location>
            <begin position="8"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Coiled-coil" evidence="4">
        <location>
            <begin position="100"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="175"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU40250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="23679" checksum="BFC5C3FC64FA7FF0" modified="2009-10-13" version="1">MAGKKENSKKVAGNARKAEAAAQKAAAEDAKKAAVEDEKWSKGAKNTAKKEAEAAKKAEAAKKKAEKDALLAEDEANTPGKAPKKSKAPVKKARGLDLSQLDDDKPSAISASGIDNALDALSLTTGGDNDKIDRHPERRFPAAYAKYEERRLQEMKSDGSGVGLRMEQRKNRIRKEFEKHPDNPFNQVTASYNATRDEVSQLRDQERAKIEQRLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7V4</accession>
    <name>C7Z7V4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ABC transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_100285</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045469.1">
        <property type="nucleotide sequence ID" value="XM_003045423.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9672631"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100285"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100285"/>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_27_6_1"/>
    <dbReference type="InParanoid" id="C7Z7V4"/>
    <dbReference type="OMA" id="MVGYCAQ"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="113"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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        </location>
    </feature>
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            <begin position="1166"/>
            <end position="1186"/>
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    </feature>
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        <location>
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        <source>
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        <source>
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            <dbReference type="PROSITE" id="PS50929"/>
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            <dbReference type="EMBL" id="EEU39756.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1459" mass="163102" checksum="B8B8587FE347CD95" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7Z5</accession>
    <name>C7Z7Z5_FUSV7</name>
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        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreomycetidae</taxon>
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        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
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                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEU39911.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="177" mass="19580" checksum="5AE6E9E4B953CAFD" modified="2009-10-13" version="1">MSDTGLPPSWEVRISNSKNLPYYFNSTDKVSRWEPPAGTDTEKLKHYMATHHSAGSRPAAAPGIPEGKIRAAHLLVKHRDSRRPSSWREAEITRSKEDAYQIIQAHEDKIKSGSITLGELALTESDCSSARKRGDLGYFGKGDMQKEFEDAAFGLQPGQMSGIVETASGLHLIERLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z883</accession>
    <name>C7Z883_FUSV7</name>
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        <recommendedName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_39578</name>
    </gene>
    <organism evidence="11 12">
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        <dbReference type="NCBI Taxonomy" id="660122"/>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045536.1">
        <property type="nucleotide sequence ID" value="XM_003045490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z883"/>
    <dbReference type="STRING" id="660122.C7Z883"/>
    <dbReference type="GeneID" id="9672567"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_39578"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_39578"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022329_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z883"/>
    <dbReference type="OMA" id="LLRKEMW"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF41">
        <property type="entry name" value="CHITIN SYNTHASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="604"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU39823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="633" mass="70995" checksum="FD8B081A70465D30" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z941</accession>
    <name>C7Z941_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_81462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045067.1">
        <property type="nucleotide sequence ID" value="XM_003045021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z941"/>
    <dbReference type="STRING" id="660122.C7Z941"/>
    <dbReference type="GeneID" id="9673078"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_81462"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_81462"/>
    <dbReference type="HOGENOM" id="CLU_1283560_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z941"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU39354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="215" mass="23879" checksum="F23A51B85C7403EB" modified="2009-10-13" version="1">MQGLLGISSSLLSTRCIRYMAVPLAENGIQPKLELLIEIFVPQVRYLSVAEVSQYYETAHPPADDLKHLIANSASWVATTTKNAQNSKRLSDSAKVAGTLGDLSLILTTATTKFMKQVLWGDDNSVKYLGDRIAEGKFNKKNTTVSMPELQTQIVKVLLAILIPATWRVSDDPKRMTSERLASFRSQHVRQRRLGEDGSTLAACLQLTKRSFSMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9D8</accession>
    <name>C7Z9D8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_70256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044790.1">
        <property type="nucleotide sequence ID" value="XM_003044744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9D8"/>
    <dbReference type="STRING" id="660122.C7Z9D8"/>
    <dbReference type="GeneID" id="9673364"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_70256"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_70256"/>
    <dbReference type="eggNOG" id="KOG3017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035730_6_2_1"/>
    <dbReference type="InParanoid" id="C7Z9D8"/>
    <dbReference type="OMA" id="TSAVRMW"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002987972" description="SCP domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="42"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU39077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="204" mass="22658" checksum="1129722F08D842E0" modified="2009-10-13" version="1">MRLLLLPLVSLLGVTLAADDVVTITAPAAIPSNEPEWKNDKTFVSAVLNSTDFYRAEHNASSLEWNRTLEDFATDYLDDNDDCEFEHSGGPYGENLAIGYGNTTASIEAWGDEREDYDFDKPKFSKATGHFSQLVWKDTTDVGCGRKLCGDRGWFLVCEYWPRGNVIGQFTDQVNKKEGNDAVRPRPGVALALAIVVGYLVVWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9E0</accession>
    <name>C7Z9E0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Small nuclear ribonucleoprotein E</fullName>
            <shortName evidence="11">snRNP-E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Sm protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_102714</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044791.1">
        <property type="nucleotide sequence ID" value="XM_003044745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9E0"/>
    <dbReference type="FunCoup" id="C7Z9E0">
        <property type="interactions" value="893"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z9E0"/>
    <dbReference type="GeneID" id="9673365"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102714"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102714"/>
    <dbReference type="eggNOG" id="KOG1774">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125186_1_1_1"/>
    <dbReference type="InParanoid" id="C7Z9E0"/>
    <dbReference type="OMA" id="VPPINCI"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01718">
        <property type="entry name" value="Sm_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000031">
        <property type="entry name" value="Small nuclear ribonucleoprotein E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027078">
        <property type="entry name" value="snRNP-E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11193">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6 11" id="KW-0747">Spliceosome</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002986913" description="Small nuclear ribonucleoprotein E" evidence="12">
        <location>
            <begin position="29"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="17"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU39078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="96" mass="10726" checksum="05BF1006FAA69CC2" modified="2009-10-13" version="1">MTGRGGGGGRRVLLLPINFIFKLLQSHATVSVWLYEQLSIRIEGKIRGFDEFMNLVIDDAVEVKQITKTNDKETRRPLGQILLKGDNVSLIQSLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZB69</accession>
    <name>C7ZB69_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhamnogalacturonase A/B/Epimerase-like pectate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_1063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044469.1">
        <property type="nucleotide sequence ID" value="XM_003044423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZB69"/>
    <dbReference type="GeneID" id="9670790"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_1063"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_1063"/>
    <dbReference type="eggNOG" id="ENOG502SK24">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002540_2_0_1"/>
    <dbReference type="InParanoid" id="C7ZB69"/>
    <dbReference type="OMA" id="AKCNGST"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="1">
        <location>
            <begin position="385"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="637" mass="69385" checksum="3E3C5DD550DD375B" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZB92</accession>
    <name>C7ZB92_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_83015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044490.1">
        <property type="nucleotide sequence ID" value="XM_003044444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZB92"/>
    <dbReference type="STRING" id="660122.C7ZB92"/>
    <dbReference type="GeneID" id="9672903"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83015"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83015"/>
    <dbReference type="HOGENOM" id="CLU_1195156_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZB92"/>
    <dbReference type="OrthoDB" id="2958217at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU38777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="26133" checksum="2939E19DBF9070D0" modified="2009-10-13" version="1">MTFYTRYGDVGKFSMKTFTFPEDKLPAISGLARVTAKKSGSKYLAGLWMEDLHIGLLWKDSINCKLRRPPRSRAPSWSWAALDRALGWKMGRSDSDMPLAKVLNADVIPGPSDPQKRLLTGSLELDGCLMTLQDAEDHDVLRGPWGNNGDYRTNSTWYVSDLGVEFTRLSRLWVLPILLGRNGIIRGLILEATSKGNASNEFRRFGWYESVPQQNRVLKALENQNTISVKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZC15</accession>
    <name>C7ZC15_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_73961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698916">
        <property type="protein sequence ID" value="EEU38513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044226.1">
        <property type="nucleotide sequence ID" value="XM_003044180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZC15"/>
    <dbReference type="GeneID" id="9670567"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_73961"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_73961"/>
    <dbReference type="HOGENOM" id="CLU_2622580_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZC15"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU38513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="78" mass="8620" checksum="28469C0E3E265285" modified="2009-10-13" version="1">MPCWMIGHSTEPQSCFNTKTVFSQPGPVRLASPPREALLALYSLIRAHNTRGRPKMASQAIEPSCVPLSLQYRGPSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZD17</accession>
    <name>C7ZD17_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_84415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698919">
        <property type="protein sequence ID" value="EEU38018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043731.1">
        <property type="nucleotide sequence ID" value="XM_003043685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZD17"/>
    <dbReference type="STRING" id="660122.C7ZD17"/>
    <dbReference type="GeneID" id="9670215"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84415"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84415"/>
    <dbReference type="eggNOG" id="ENOG502SICY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002639_3_1_1"/>
    <dbReference type="InParanoid" id="C7ZD17"/>
    <dbReference type="OMA" id="FNFIRRC"/>
    <dbReference type="OrthoDB" id="5362512at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="198"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="658" mass="74752" checksum="83168C9429C737B0" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZD32</accession>
    <name>C7ZD32_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_84430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698919">
        <property type="protein sequence ID" value="EEU38149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043862.1">
        <property type="nucleotide sequence ID" value="XM_003043816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZD32"/>
    <dbReference type="GeneID" id="9670224"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84430"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84430"/>
    <dbReference type="eggNOG" id="KOG2317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_7_3_1"/>
    <dbReference type="InParanoid" id="C7ZD32"/>
    <dbReference type="OMA" id="AWDENSN"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF58">
        <property type="entry name" value="PROTEIN HMF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="126" mass="14076" checksum="186EFAFA76A85567" modified="2009-10-13" version="1">MKTICPSRAPRTIGPYVHAVVHGDFVFTTACIPLDPETNKLIEGDAEAQLRRIFENLKIILQESGTTLNHIIKQNVYLTNFDDFEAFNKVSAEYLGEHRPARATMKVLELPKGARMGLDVVAALPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZD83</accession>
    <name>C7ZD83_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_48372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698919">
        <property type="protein sequence ID" value="EEU38176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043889.1">
        <property type="nucleotide sequence ID" value="XM_003043843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZD83"/>
    <dbReference type="GeneID" id="9670048"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_48372"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_48372"/>
    <dbReference type="eggNOG" id="ENOG502QWA6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009942_5_0_1"/>
    <dbReference type="InParanoid" id="C7ZD83"/>
    <dbReference type="OMA" id="HPRDDHR"/>
    <dbReference type="OrthoDB" id="3501663at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF20">
        <property type="entry name" value="AMIDOHYDROLASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase 3" evidence="1">
        <location>
            <begin position="52"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="534" mass="58579" checksum="1D967618DBDFED99" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDL3</accession>
    <name>C7ZDL3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_88323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043559.1">
        <property type="nucleotide sequence ID" value="XM_003043513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZDL3"/>
    <dbReference type="GeneID" id="9669876"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88323"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88323"/>
    <dbReference type="HOGENOM" id="CLU_1461698_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZDL3"/>
    <dbReference type="OMA" id="ETHNMTV"/>
    <dbReference type="OrthoDB" id="5104208at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002987023" evidence="2">
        <location>
            <begin position="23"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU37846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="185" mass="17964" checksum="F59890D02A8EE4D5" modified="2009-10-13" version="1">MKSSSTLTLLALLTSALAGATTERPSCVTTKTLPPITIYSCPGDSEPTKTVFTPVQSSNPALKPGAPGSSGAPNVPGVPGAPGQPDGSEEPNAGQNDGNIPNPQQPNAPESAGSAPSPGSESGSGPNSHPGQPVGTAEPSTTGPGVAPGSPETPSVIAVAGAPTVQLDLLLFSTAALAALAMVWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEE7</accession>
    <name>C7ZEE7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_97646</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698921">
        <property type="protein sequence ID" value="EEU37661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043374.1">
        <property type="nucleotide sequence ID" value="XM_003043328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEE7"/>
    <dbReference type="STRING" id="660122.C7ZEE7"/>
    <dbReference type="GeneID" id="9665377"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_97646"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_97646"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_1_2_1"/>
    <dbReference type="InParanoid" id="C7ZEE7"/>
    <dbReference type="OMA" id="AQQYVAF"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF34">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G02770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="88"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU37661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="533" mass="57262" checksum="164B32EAD2E09502" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEM1</accession>
    <name>C7ZEM1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_102141</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698921">
        <property type="protein sequence ID" value="EEU37721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043434.1">
        <property type="nucleotide sequence ID" value="XM_003043388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEM1"/>
    <dbReference type="GeneID" id="9669143"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102141"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102141"/>
    <dbReference type="eggNOG" id="ENOG502SPV3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023417_3_0_1"/>
    <dbReference type="InParanoid" id="C7ZEM1"/>
    <dbReference type="OMA" id="SWEVTRM"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU37721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="495" mass="56532" checksum="71B0B1F929292171" modified="2009-10-13" version="1">MAGSTKGKAKLRTKTGCLTCRQRRKKCDEKSPVCGNCASVARECQWPSSKDMIDRRHMSHDRSRYREYRSKSPCQQSPKPLDLELARAESPESPCSPVHSDVSVCLHSEVAISHSIISRDLETCLSHHFANKYYSLLLLPSSHPGFHDGWLTEIKQLMVDHKSLYYSVLALAASHIYLIDGSWCMHDLTLRYYSNALTELAQLVANVSEFENHNGLLMSVMLLYIHGSMSWDTDIDVPQHISAASRIITLRLLNRPVGIGRLFDRLAVESVMYHTFSITTGLWSETERVSYDFDPDFWDRAEKLLDRSLFFPGAPRGLNSPVLGVPVSLFRIALFLRRYFSNCCPRSAEFERLQGEVASWEALLLDDKELRSGSFGEAESLTSRERYFRDVSYLFALAASLLLEQASQRGTTTPPLMVPSNCWQIQLTRRILRQHVGDDGWAKCFIGNWPIYTLGLFMESKADRTVVRAELKRRWELTRFVQAARFGRDLEEAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZF41</accession>
    <name>C7ZF41_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAD-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_51518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043214.1">
        <property type="nucleotide sequence ID" value="XM_003043168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZF41"/>
    <dbReference type="STRING" id="660122.C7ZF41"/>
    <dbReference type="GeneID" id="9665319"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51518"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51518"/>
    <dbReference type="eggNOG" id="ENOG502QTXV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019989_2_0_1"/>
    <dbReference type="InParanoid" id="C7ZF41"/>
    <dbReference type="OMA" id="FYHYNRG"/>
    <dbReference type="OrthoDB" id="2012566at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43611">
        <property type="entry name" value="ALPHA-D-GLUCOSE 1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43611:SF3">
        <property type="entry name" value="FLAVIN MONONUCLEOTIDE HYDROLASE 1, CHLOROPLATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU37501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="53059" checksum="E97B49856FC40979" modified="2009-10-13" version="1" fragment="single">FSSLVLDLGGVLLLYSANNVKTLTPRQISNALDSPIWHDYERSKTSKKSCYDAICRDFGFNPTSWAEALDVMRESLRPNKELIEEIKKLKLNNSELKVFGLSNVPTEDFQDLKPLIEEWGIFDDFYASGLTGFRKPDIACYERFLEDCMIPSEACIFVDDRIENVVAAQSLGFRGVHLTDTSSVVATLNNLLGDPVARGLEFLRRNAKNLFCETNKGETQPDNYSQLIILEHTGDRLVQLGTTFIGEPVFFDTVYPNDADTTSLAMHVLGDVSAEEESFAVNEILSHLNPDGLPYCWLQTCRPRFCHGICANVFRYFYLSGQIDKLPNVYQYLCRLLKTEAYLLGTRYYENPDWFLFLLSDVCGKRPDDEALNEMRRLLSSQIQDRVGCDRNLFGAALRSLAAQALGIMNKRDIKTLLETQLLDGGWEKQWLWKYGKEAVKLGSRGVITTMAVRAIKRAREDAPILTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZH74</accession>
    <name>C7ZH74_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Copper-containing nitrite reductase</fullName>
            <ecNumber evidence="4">1.7.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_51971</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>nitric oxide + Fe(III)-[cytochrome c] + H2O = Fe(II)-[cytochrome c] + nitrite + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Cu(+)</name>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.2.1" evidence="4"/>
    <dbReference type="EMBL" id="GG698927">
        <property type="protein sequence ID" value="EEU36614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042327.1">
        <property type="nucleotide sequence ID" value="XM_003042281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZH74"/>
    <dbReference type="STRING" id="660122.C7ZH74"/>
    <dbReference type="GeneID" id="9669657"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51971"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51971"/>
    <dbReference type="eggNOG" id="ENOG502S0TZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031740_1_2_1"/>
    <dbReference type="InParanoid" id="C7ZH74"/>
    <dbReference type="OMA" id="HPIAGIW"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050421">
        <property type="term" value="F:nitrite reductase (NO-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd11020">
        <property type="entry name" value="CuRO_1_CuNIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04208">
        <property type="entry name" value="CuRO_2_CuNIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000093">
        <property type="entry name" value="Copper-containing nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001287">
        <property type="entry name" value="NO2-reductase_Cu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00695">
        <property type="entry name" value="CUNO2RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0186">Copper</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="13">
        <location>
            <begin position="64"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="12">
        <location>
            <begin position="223"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="11">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="11">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="11">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="11">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="11">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="11">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="11">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601287-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU36614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="350" mass="37690" checksum="E436C4BC3EB07639" modified="2009-10-13" version="1">MVPAISGDPNVQAFEPITENGVQLADLPVENAILTTAPNVPPAITRDHPALVKVPLITTTKLAQLTSQYKYEQWTFNGTVPGPFIRAKVGDVVELSLTNKDPAGNPHNIDCHAFTGPGGGAAVTTAEENETKTARFKLLYPGLYLYHCAAAPVPVHIANGMYGLMYVQPEGEDLPPVDKEYYVMQSEFYHEPPEVDDDGRRSEIVEFSYPNGLREEPQVVAFNGSESALTRDKPLKANVGDNVRIFFGNAGPNLTSSFHIIGSHFKNVYRDGGVLSPPSQGIQTVSVPSGGSTIVDLKMAVPGTYTLIDHAIFRLDKGAVGFLNVSGSPNPVVYQSPQPPRPCVGCKLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZH76</accession>
    <name>C7ZH76_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phenolic acid decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_105605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698927">
        <property type="protein sequence ID" value="EEU36704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042417.1">
        <property type="nucleotide sequence ID" value="XM_003042371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZH76"/>
    <dbReference type="GeneID" id="9669495"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_105605"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_105605"/>
    <dbReference type="eggNOG" id="ENOG502QRS2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104261_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZH76"/>
    <dbReference type="OMA" id="WEHAEDA"/>
    <dbReference type="OrthoDB" id="4415004at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008729">
        <property type="entry name" value="PA_de_COase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40087">
        <property type="entry name" value="PHENOLIC ACID DECARBOXYLASE PADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40087:SF1">
        <property type="entry name" value="PHENOLIC ACID DECARBOXYLASE PADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05870">
        <property type="entry name" value="PA_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU36704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="20148" checksum="8242F0F514A2E5F7" modified="2009-10-13" version="1">MALPRYQTNTPLDPSFEDDIRDTHLVYDYNATDAQGNPEKWRYEIWFFSEDRVVYAIHGGPMAGRINYQTAAYQCVRPGELWQINWLEETGTIVSLVYDITSKKVNGMLGFSRGHWEHAEEAHGDKRNPEDFERWKGLAAIGKQTDRFILTEQANILEIFKGKGGLVPITPDAPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZH96</accession>
    <name>C7ZH96_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_51764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698927">
        <property type="protein sequence ID" value="EEU36714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042427.1">
        <property type="nucleotide sequence ID" value="XM_003042381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZH96"/>
    <dbReference type="STRING" id="660122.C7ZH96"/>
    <dbReference type="GeneID" id="9669667"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51764"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51764"/>
    <dbReference type="eggNOG" id="ENOG502R9P4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096872_2_1_1"/>
    <dbReference type="InParanoid" id="C7ZH96"/>
    <dbReference type="OMA" id="DAWNFAS"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020915">
        <property type="entry name" value="UPF0311"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315:SF1">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11578">
        <property type="entry name" value="DUF3237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU36714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="135" mass="14265" checksum="C9910C8153204D50" modified="2009-10-13" version="1" fragment="single">LAYLFRMNLTLSSTINTGPGPSGTRLAIPITGGTFSGPKGKGTRTVLPIGADFGTIDALGNFNVDAHSVIQMDDGSYVYSHSTGPLISGQTALDRVKFETGSSKYSWLNEILAVAVTDFPGPWVSLDVWQVNPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHU9</accession>
    <name>C7ZHU9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7600 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_86874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698929">
        <property type="protein sequence ID" value="EEU36344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042057.1">
        <property type="nucleotide sequence ID" value="XM_003042011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHU9"/>
    <dbReference type="GeneID" id="9669055"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86874"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86874"/>
    <dbReference type="eggNOG" id="ENOG502SZ3F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012355_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZHU9"/>
    <dbReference type="OMA" id="YPWEEAR"/>
    <dbReference type="OrthoDB" id="5273847at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056021">
        <property type="entry name" value="DUF7600"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24539">
        <property type="entry name" value="DUF7600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002987112" description="DUF7600 domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7600" evidence="2">
        <location>
            <begin position="411"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU36344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="755" mass="84982" checksum="CFE7E1853A1F86B1" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHZ5</accession>
    <name>C7ZHZ5_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_52602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698929">
        <property type="protein sequence ID" value="EEU36365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042078.1">
        <property type="nucleotide sequence ID" value="XM_003042032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHZ5"/>
    <dbReference type="GeneID" id="9674414"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_52602"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_52602"/>
    <dbReference type="eggNOG" id="ENOG502S4EJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015639_2_0_1"/>
    <dbReference type="InParanoid" id="C7ZHZ5"/>
    <dbReference type="OMA" id="NIWHRID"/>
    <dbReference type="OrthoDB" id="5428040at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="596"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU36365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="691" mass="76249" checksum="93BD7C9105F7BCB7" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZI22</accession>
    <name>C7ZI22_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_102059</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698929">
        <property type="protein sequence ID" value="EEU36325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042038.1">
        <property type="nucleotide sequence ID" value="XM_003041992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZI22"/>
    <dbReference type="STRING" id="660122.C7ZI22"/>
    <dbReference type="GeneID" id="9669032"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102059"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102059"/>
    <dbReference type="eggNOG" id="KOG0069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_1"/>
    <dbReference type="InParanoid" id="C7ZI22"/>
    <dbReference type="OMA" id="LANYSQM"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05198">
        <property type="entry name" value="formate_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050418">
        <property type="entry name" value="D-iso_2-hydroxyacid_DH_PdxB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G13630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="40"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="166"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU36325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="38544" checksum="5D73C9DE587F1DFE" modified="2009-10-13" version="1">MASQAAEKVQSPSRLPDNTHHVIVKLETIHVPAPAIDLSPLTHELITYEYTPPAAKALIAARIHDASIVTLTTVPINAETLGEAPYLKCVISETTGTNHIDLEECKKRNITVMFSPHAATEAVSEHALGLYFSVRRSFVRLHNTLFADSPNAWANSGSMSNILKDTQGQPPHTCGNETVGILGFGALGQRIARLCEALGMKVLVAARKEAGIGPGSNSGDSQRIAFDEVLRRATVLFITLPLTPQTRNTIGSEELQSMRHDAVLINVGRGGLVDEKALVQALRQRLIHGAATDVFEHEPAGSDHDSVLLSEEAKDLNLTLTPHLAWCADQTTVNMQEIIVQNLKEYLRGGSRNVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZI97</accession>
    <name>C7ZI97_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ornithine aminotransferase</fullName>
            <ecNumber evidence="5">2.6.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_52835</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 2-oxocarboxylate + L-ornithine = L-glutamate 5-semialdehyde + an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:13877"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="EC" id="2.6.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="5"/>
    <dbReference type="EMBL" id="GG698930">
        <property type="protein sequence ID" value="EEU36166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041879.1">
        <property type="nucleotide sequence ID" value="XM_003041833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZI97"/>
    <dbReference type="STRING" id="660122.C7ZI97"/>
    <dbReference type="GeneID" id="9674351"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_52835"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_52835"/>
    <dbReference type="eggNOG" id="KOG1402">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_3_1"/>
    <dbReference type="InParanoid" id="C7ZI97"/>
    <dbReference type="OMA" id="WMGPENK"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019544">
        <property type="term" value="P:L-arginine catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010121">
        <property type="term" value="P:L-arginine catabolic process to proline via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="ORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU36166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="445" mass="48761" checksum="C34656E62E9B47C7" modified="2009-10-13" version="1">MSTKSGELIPGAAQELLQLEEKYSVGGFAPTPGFPVLGKGSTLIVYEPLVRLIEAVVETPAKESASTILCIFPALANSCALATLINMSTHYAGWPKLAKELCERFGYDKVTAMVSGAEAADTACKIARKWGIVHKGIAPEEGLVLGTSDNYHGLTSGIWPIMTPGSQEGYAVFSKNITNRHPRTGELLRYGHVQDFEAVFEEFHGRISGVIMECIHGKLRTFQEEIDFASGVRRLCKKYNILFISDEIRMGSAKTGKFLCSDWLGPENKPDMITLGKSITGGVFPASYVLGNNEAMSLVESFQTGGTFTMAPAAVAATTAALKIYDEEKLCEKAFVIEAKWKETTSKWNYPWIKYVTSRGADMSIATEQRYGTVTPRRIARLAWQKGLFIYPTKASIRVHMALNISDEELEKGLKILTNVMDQIESYGDIPGSTHPSDDAKHGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZID2</accession>
    <name>C7ZID2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bulb-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_102073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698930">
        <property type="protein sequence ID" value="EEU36185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041898.1">
        <property type="nucleotide sequence ID" value="XM_003041852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZID2"/>
    <dbReference type="GeneID" id="9674312"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102073"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102073"/>
    <dbReference type="eggNOG" id="ENOG502S40P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137596_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZID2"/>
    <dbReference type="OMA" id="VICAVQN"/>
    <dbReference type="OrthoDB" id="1884773at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.10">
        <property type="entry name" value="Bulb-type lectin domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001480">
        <property type="entry name" value="Bulb-type_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00108">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="alpha-D-mannose-specific plant lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50927">
        <property type="entry name" value="BULB_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bulb-type lectin" evidence="1">
        <location>
            <begin position="2"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU36185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="114" mass="12735" checksum="EA22A47C22135C14" modified="2009-10-13" version="1">MSGTLKNGEWLKVGESLWSPDGSVELKMQEDGKLAIYWEGECRFQTTDEQRDDIDGIQIQEDGNFVIYDNDGNAVWASDTAEPTGDSSVEVVVQDDGNVVLYKKTAIWCSETHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZIF5</accession>
    <name>C7ZIF5_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_87124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698930">
        <property type="protein sequence ID" value="EEU36254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041967.1">
        <property type="nucleotide sequence ID" value="XM_003041921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZIF5"/>
    <dbReference type="STRING" id="660122.C7ZIF5"/>
    <dbReference type="GeneID" id="9674321"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87124"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87124"/>
    <dbReference type="eggNOG" id="ENOG502RNVH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047021_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZIF5"/>
    <dbReference type="OMA" id="TEYFRFC"/>
    <dbReference type="OrthoDB" id="5427059at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU36254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="386" mass="44301" checksum="7431740366314AC0" modified="2009-10-13" version="1">MTPPLQRLPLHIVAEILGQLDTIQELGPPIFSHRIFHDAVQDSLHAISRRILTRQVPDGILSYSLILLETTQIDVMDQNAVDPLIARLEKIDQSPSLVHLSLAEYAFISQNQTAVKWMSQDMAHELIPAINEVGFTHPETLSDNEIFRMYRAFLRYQIMCNLFCHGPCRQKLEVTEQISDFCRASSQWVNDQLLAVYSYLERRVSFAFDHVGAHNVEWAGVPIEWNESFEDCNRIQRLLCRGLPFLCALAHSKTYHERLNVLKLKIVRSNASVPDPPCNLISILLWCPRQAGDVAGNTWTVIRRGPPVSSYTAKELEEEAYRKLSIFAYTMWDNADLTVEQLGEICTNIAGCKDYFKRYARYWDGKDLRLAQKRKKNIYNAGGRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJQ7</accession>
    <name>C7ZJQ7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_44376</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GG698935">
        <property type="protein sequence ID" value="EEU35744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041457.1">
        <property type="nucleotide sequence ID" value="XM_003041411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJQ7"/>
    <dbReference type="STRING" id="660122.C7ZJQ7"/>
    <dbReference type="GeneID" id="9673836"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_44376"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_44376"/>
    <dbReference type="eggNOG" id="KOG3968">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012358_11_1_1"/>
    <dbReference type="InParanoid" id="C7ZJQ7"/>
    <dbReference type="OMA" id="EMITECA"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF37">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988173" description="Amidohydrolase-related domain-containing protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="6">
        <location>
            <begin position="78"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU35744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="502" mass="55297" checksum="E42EB48213F5268A" modified="2009-10-13" version="1">MKGTSFLTASIFLFTIARAAVLFEGGTIISYDEVNHNVKVLKGYSMLVEKDKISAIYDASKSRSLPTGTEIVSAAGKILSPGFIDTHRHGWQTAFKTLGSNSTLADYVLQWSEHGPAGTRFTAEDVYYSQLIGLHDAIDAGVTGILEHAHCTFSNETSRASLQASVDSGLRIWWAYAFHELSNGFSVEEQLANFRDLYEKDTWNNSAVEMAIGYDLFDRASEEQSRQIIKLAIDYNVSALTTHYLGGSHFAFNSPQLLNQLGLLNIGIPIIFSHGTEITTQDILLLREHNHYVSITPESEMHYGIGFPHGYKIQDQAALGVDTNFAFSSSIITQARTWLQVVRKQLTDGIVQAWKVPSNSPMSVNQAFLMATRNGGRAMGRDDVGVLKVGAKADIVVFDAPSANFLGWRDPVAAIILHSHPGNIEHVMVDGQFLKRNFSVVTLDGSHVNITEARERFLESADRIQKIWLNDPPELEQGQNGAGIPYVTLDRVDVIAGEGIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJY2</accession>
    <name>C7ZJY2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_87975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698936">
        <property type="protein sequence ID" value="EEU35672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041385.1">
        <property type="nucleotide sequence ID" value="XM_003041339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJY2"/>
    <dbReference type="STRING" id="660122.C7ZJY2"/>
    <dbReference type="GeneID" id="9676293"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87975"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87975"/>
    <dbReference type="HOGENOM" id="CLU_1611231_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZJY2"/>
    <dbReference type="OMA" id="SFQIQPF"/>
    <dbReference type="OrthoDB" id="2496787at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="2">
        <location>
            <begin position="28"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU35672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="165" mass="18992" checksum="9A5B287133C0A98E" modified="2009-10-13" version="1">MSPRFSTYLYRPPTDPIQLVVVVAFNVFCQILLIFLHKFQAVVRWTMGLTVLLCLIYLILFLIQRMPLWLFWEGWKDKTPRGVIVDGNAMGISHGTLNVALDIWMLILPLSQRLKSGVKFNKKVGVVAMFSSHHSQYDSDSKSLGLFSIVERDRSVPEDHLVNWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZK55</accession>
    <name>C7ZK55_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_52357</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698937">
        <property type="protein sequence ID" value="EEU35581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041294.1">
        <property type="nucleotide sequence ID" value="XM_003041248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZK55"/>
    <dbReference type="STRING" id="660122.C7ZK55"/>
    <dbReference type="GeneID" id="9676002"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_52357"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_52357"/>
    <dbReference type="eggNOG" id="KOG1411">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032440_0_1_1"/>
    <dbReference type="InParanoid" id="C7ZK55"/>
    <dbReference type="OMA" id="PTWGNYK"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="27"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU35581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="351" mass="38927" checksum="054AC13854ADCB5D" modified="2009-10-13" version="1">MFKSFQRGPVDPMFILKKKADEDVSPDKADLGVGIYRNEAGLYSELDSVKQAKLALAQNDPGHDYELTTGNAQFLEKAAALLFGKDCQKLKSGQIASVQTISGTGANHIAALALSQSVSPLPQVFVGVPAWGNYKPMFELVGMQVTEYSYYDPKNRTIDFSSIIQAARTAPPRSVFILQGCCHNPTGTDPTKAQWNELASVLEENRHFIFLDIAYQGLGDGMDEDAYAVRLFAKSNVDMFVCQSFSKNFALYGERCGVLHAVCADAKTASDVHDRLRCLIRWEFSSSPAYGSRLVDIVLGSDQRTEAWTTELSEMSQRLKSLRKKLHSYLTQDLKTPGNWEHILKETGLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKE6</accession>
    <name>C7ZKE6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_55576</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698938">
        <property type="protein sequence ID" value="EEU35546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041259.1">
        <property type="nucleotide sequence ID" value="XM_003041213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKE6"/>
    <dbReference type="STRING" id="660122.C7ZKE6"/>
    <dbReference type="GeneID" id="9675979"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55576"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55576"/>
    <dbReference type="eggNOG" id="ENOG502R6B0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060572_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZKE6"/>
    <dbReference type="OMA" id="INDRPMV"/>
    <dbReference type="OrthoDB" id="2205143at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02216">
        <property type="entry name" value="cupin_GDO-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047183">
        <property type="entry name" value="GDO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41517">
        <property type="entry name" value="1,2-DIOXYGENASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41517:SF1">
        <property type="entry name" value="CUPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="3">
        <location>
            <begin position="102"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU35546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="317" mass="35356" checksum="218E592C9B2B6827" modified="2009-10-13" version="1">MASTSETEAAVQAATDKIIDYCRQNNSYPMWTVTNKVSKLSPNPKALPTRWAWSDFRKILLETCTIVPEHMAERRALMMVNPGFPAVNGSSPFTTDTLYAGFQTVLSGETAPAHRHMAYAVRLILESDKGFTSVAGHKIYLEAGDFVLTPSWEWHYHGNDGTTPTIWVDCLDIPLHIFARINFLELYPTPSVPDLVTQGSPFHFSWKEAKRALDSQAGPHAIYHYLRNAEKFSKGYAIKAFQETCSFIYVVINGSGLSKIKSPAGESTIEWKEKDVFVVPAWSCVEHVCSDESDTYLIALTDRAFGEALGLSRVTYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKU5</accession>
    <name>C7ZKU5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_61688</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0507 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698941">
        <property type="protein sequence ID" value="EEU35391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041104.1">
        <property type="nucleotide sequence ID" value="XM_003041058.1"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZKU5"/>
    <dbReference type="GeneID" id="9675557"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_61688"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_61688"/>
    <dbReference type="eggNOG" id="ENOG502R3ZQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002294_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZKU5"/>
    <dbReference type="OMA" id="HFPMIAR"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097422">
        <property type="term" value="C:tubular endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000443">
        <property type="entry name" value="Putative vps9 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051248">
        <property type="entry name" value="UPF0507/Ank_repeat_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G09870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="3">
        <location>
            <begin position="345"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="524"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1277"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="545"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1311"/>
            <end position="1320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU35391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1320" mass="146953" checksum="846FCC57D4B2D0AA" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKX4</accession>
    <name>C7ZKX4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_36933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698942">
        <property type="protein sequence ID" value="EEU35309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041022.1">
        <property type="nucleotide sequence ID" value="XM_003040976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKX4"/>
    <dbReference type="GeneID" id="9675414"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_36933"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_36933"/>
    <dbReference type="eggNOG" id="ENOG502S4U3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_685169_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZKX4"/>
    <dbReference type="OMA" id="RAGWNTY"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF3">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="344" mass="37912" checksum="95EDE195683B6549" modified="2009-10-13" version="1">MSDRRRRNVIVTGANGYIGSAVCRAFVRAGWQTFGLIRRPEVAEELILSEAIPVIGTFTDLAFLKTLFEQVNTFDVIVSCTEKVTGYAAHFEEVVTCVRALAEESNQNGTRPLVLWSSGCKDYGTTGLDGSPGLAPHDENSPLNAPEMLKERTTNCLRIFDDASLFDAAVIRPTSVFGYSSSYYGAIFDFVADQKREGTETLRVPGDPNSIMHATHVDDCAEAYVALAEHSNRSAVAGQAFNISGYRYETLKEVATSLAKEYGFKNGVEFVPASEAGPSFPPLLHLALSFSQWVGSQKLRSLCGWNDRRALFSESIHVHRLAYETLKERGHRNVADIQKRVQGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZM45</accession>
    <name>C7ZM45_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_68902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698949">
        <property type="protein sequence ID" value="EEU34902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040615.1">
        <property type="nucleotide sequence ID" value="XM_003040569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZM45"/>
    <dbReference type="FunCoup" id="C7ZM45">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="GeneID" id="9679051"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_68902"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_68902"/>
    <dbReference type="eggNOG" id="ENOG502QTP0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035734_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZM45"/>
    <dbReference type="OMA" id="EFFYLGY"/>
    <dbReference type="OrthoDB" id="2140105at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022703">
        <property type="entry name" value="DUF3533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053001">
        <property type="entry name" value="MNNG_permease-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814:SF2">
        <property type="entry name" value="DUF3533 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12051">
        <property type="entry name" value="DUF3533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3533" evidence="2">
        <location>
            <begin position="33"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU34902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="411" mass="46385" checksum="6A96C7E8FABB81A4" modified="2009-10-13" version="1">MHLISSFYSRARDEPVPGKTPQLFFKLAGTSFIYFQLLFFGLFCYILGSLFQQTDHTHNIRITFVDYDRDAIGRAVRLAYASIEGKAFPTLVERPASEFPTINDLVGTVCRTEYWGALYVVKGASLRLHEALAGDKTYNNTDAMGYIWNEAFYSSIIDSAVSVNLQLLSDTARVAYTTANGTANISSITSPAALSAFANPWELQSINIKPTPQGSRAIYNTVVIIIVLMQQFFYLGTLNGRYAQLKVYTLVNPYRIIITRNMITLSYTFIGSLLTMGAIWAFRAGWDVNGNQFVLSWITLWLFAHINFLIFEIFTIWLQSSFVPMALISWIVFNITSVLLPFQLSPGFYHIGYMFPAHNYYQVLINIWSLGCNPKLHYALPVLFAWELVALVLTSVGVFRRCHLAMAARAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMD1</accession>
    <name>C7ZMD1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_55114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698951">
        <property type="protein sequence ID" value="EEU34832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040545.1">
        <property type="nucleotide sequence ID" value="XM_003040499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMD1"/>
    <dbReference type="GeneID" id="9678960"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55114"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55114"/>
    <dbReference type="eggNOG" id="ENOG502S8FX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031555_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZMD1"/>
    <dbReference type="OMA" id="MNVIHGR"/>
    <dbReference type="OrthoDB" id="5326346at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="44854" checksum="ED5CCDB0D5BD5FD5" modified="2009-10-13" version="1">MKRSTYEFSHSNDTLLILHTCRLHSFQWSSDSLWTPYKQEIENDSIKRKGKKSKKSKKRRVHHNEQPSPASCGSNGNENIDMDSTTQTAERTLGESPGIRHGQVCYQMLVSSAHLSQASPVFRKMLNGLFAEAVADSQGLYRITTTGWDPEALVIVLDIMHGHNRSVPRQLTLEMIAKVAMIVDYYDCLEIVEVFAGIWVDALAESQSGTYGKDSMLWLLVSWVFQRQDIFEKMTGLALRHSERLITVGYVPIPHVILRRINEERQNALTQIFSKLYELLDTLCQESECSYECSSMLLGSLMKELSKRDILKPQIKKPFEGYNIASAAQMVDTFASPTWYSQIRHYHSYNLPHTCSISGKMRPTLDRVESKAPVLTLEDFRFSADYGKLAGLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMH4</accession>
    <name>C7ZMH4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_82378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698953">
        <property type="protein sequence ID" value="EEU34749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040462.1">
        <property type="nucleotide sequence ID" value="XM_003040416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMH4"/>
    <dbReference type="GeneID" id="9678908"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82378"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82378"/>
    <dbReference type="eggNOG" id="ENOG502T49S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_735746_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZMH4"/>
    <dbReference type="OMA" id="CPKEFEA"/>
    <dbReference type="OrthoDB" id="3009728at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002989416" evidence="2">
        <location>
            <begin position="23"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU34749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="379" mass="41993" checksum="4FD7D53F894964F5" modified="2009-10-13" version="1">MRPSNALYLWVAHCLYISPATAALDRTRSQFKHFFPTVEKFAKPRFHKACPEQFANYFNESLPDPGYGHKYSGELMECILEEWGELNKANMAVTAILLALLPSGLVQFGPSMAEISILSTRRPILATFLGFGLMSPNPAEFDFEGILQKAGSGSAPLAPIRALDGRYFIAKVLVSLVEYVIAMGSTGNFFYQVYRFTYHSISLAPLVVYVHGIPEAATLFGWAVLNLPLYLLSFVVFALAFHRATPQSGYKRRNRLVEFIIAELTPCGQGPNLRLQQRGTRETLRRLLGALTRLIAGLHIILGTVLIGSIVLIPLGDSLPVIYSFVFAAILTRAVLSYEISCLARRTEIEPAHDLGSDQVVHETHSLGPKQYEGLSQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQ48</accession>
    <name>C7ZQ48_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_82305</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698982">
        <property type="protein sequence ID" value="EEU33867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039580.1">
        <property type="nucleotide sequence ID" value="XM_003039534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQ48"/>
    <dbReference type="GeneID" id="9667096"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82305"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82305"/>
    <dbReference type="eggNOG" id="ENOG502SMZI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_10_0_1"/>
    <dbReference type="InParanoid" id="C7ZQ48"/>
    <dbReference type="OrthoDB" id="5273647at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF92">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="26"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU33867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="378" mass="42293" checksum="C437BA433033F2A9" modified="2009-10-13" version="1">MAAPSTAGALACFWILLCASAILIAARLWLRLKIQHQALLLSDALLLIAWCSSLTHAVFVIIFAVKGALHPDIDYTLINWKVNVTEVEFITRMIWSSVFPFFTSLYFCKFALLATYLQLFPRFMKKLRVALYVAIAYCVSGYLVSMSVQLFLCWPIEGNWSFASNPAVVCEPKIIGTIFYIAWSLHFTANLSIIILPFFILKNLQVKKKTMVGIYAIFSLGIIDIAFSLTRFLTIHLGSGGFKPLTLIQIWSILDENMALIIACLPSLRPYLRHGFKSSSAEASYGYGNRSTGHITSTRKTQATSGFEVIDDPVPVFDGGLHRNTRRGNDSEDDAWSDGKKSNRSDIELVTIQAQRGDRTSTVHQGQIRVEQGFIVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQF8</accession>
    <name>C7ZQF8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PD-(D/E)XK nuclease-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_102287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698991">
        <property type="protein sequence ID" value="EEU33750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039463.1">
        <property type="nucleotide sequence ID" value="XM_003039417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQF8"/>
    <dbReference type="STRING" id="660122.C7ZQF8"/>
    <dbReference type="GeneID" id="9666982"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102287"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102287"/>
    <dbReference type="eggNOG" id="ENOG502SSXD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027219_0_3_1"/>
    <dbReference type="InParanoid" id="C7ZQF8"/>
    <dbReference type="OMA" id="EDGWISG"/>
    <dbReference type="OrthoDB" id="4161186at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046797">
        <property type="entry name" value="PDDEXK_12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20516">
        <property type="entry name" value="PDDEXK_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PD-(D/E)XK nuclease-like" evidence="2">
        <location>
            <begin position="174"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU33750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="436" mass="48286" checksum="032446411D2EA246" modified="2009-10-13" version="1">MRPQDIVSWLAHIKSTTHGPSDTPRLDDPTPTNTHQHHPPSPPESPKKRLAMDDPESPAPKRQKVHEDPNRTPKASSSRQGLGYLRTTSPTTSLPAPTPTPTASDTQSSASGRSSPSKQLASLEISTEGVEQRKLSLADPSLPPALSDLLLELQSCSSSGVGIVSSTLRAEIREQAKTDATFRVFMDHMFAAAADRDQLGPTLPVDEATRLVEEAAECQVSKQNELGWNQMVHNPLLYSAIYGRRRRDQLVGFAPCTTAKIIREYLPATTPAKMVDYCVYFDPKADPVASEAIQTLRRSLVSQVINHSDFQPFRKRPIAISIETKSRDRTWSEAAALQIGTWHSAQWRFLEHLVNRSGGSFGGLPFLPAVLVHGHDWSFAATTREGRKTVLWLEHPFGSSSDVVGVYKTVWCLQRLAQWAAEVYWPWFRENCLGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQV5</accession>
    <name>C7ZQV5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_9815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699015">
        <property type="protein sequence ID" value="EEU33600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039313.1">
        <property type="nucleotide sequence ID" value="XM_003039267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQV5"/>
    <dbReference type="GeneID" id="9666833"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_9815"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_9815"/>
    <dbReference type="HOGENOM" id="CLU_2892087_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZQV5"/>
    <dbReference type="OMA" id="EYYLAYT"/>
    <dbReference type="OrthoDB" id="5238092at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="19"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU33600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="63" mass="7762" checksum="CC1099475AA60215" modified="2009-10-13" version="1" fragment="single">LSDELLYHVGYEGKRRLYIPRPLVKSILEIIHDNKHHFEINRMTQELDPVYFYRMSKIIRNYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQZ6</accession>
    <name>C7ZQZ6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PD-(D/E)XK nuclease-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_89364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699022">
        <property type="protein sequence ID" value="EEU33553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039266.1">
        <property type="nucleotide sequence ID" value="XM_003039220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQZ6"/>
    <dbReference type="STRING" id="660122.C7ZQZ6"/>
    <dbReference type="GeneID" id="9666788"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89364"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89364"/>
    <dbReference type="eggNOG" id="ENOG502RS8A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027219_0_3_1"/>
    <dbReference type="InParanoid" id="C7ZQZ6"/>
    <dbReference type="OrthoDB" id="4161186at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046797">
        <property type="entry name" value="PDDEXK_12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20516">
        <property type="entry name" value="PDDEXK_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PD-(D/E)XK nuclease-like" evidence="2">
        <location>
            <begin position="179"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU33553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="418" mass="46890" checksum="87B472F8CD661D2C" modified="2009-10-13" version="1">MIAQRRVIEWIENLPSTFVLLQNQPQPSITQRTERQIRSNKRKTPQEPSPPATVSDMDDPETPTRKKQRIDLVPDLDLTPRGRPEPSSDPTKAPSLSGSNTSGASRSTSPLKRQFLELGLDDTGMETRALSVDALEALPNPDAAALLRTMRRIGTCRGILPDDRRKDILQSHQIKGSDLEDWDSAFKKSSAFADLPGRIPSPSEVDLVREWTTDCIELKHEVAGWNDEVHFRLLEAVFREPGKKKGGLFNIATTHTARPHKTWLPKSIGIKMVDFCVYADTAEKDALSLETHKAFCRATLTKSVNHTDFQRLQVRPIVLSIETKAGNKDLDAAELQIGVWHAAQWAFLRSSLLLINRASPGRPPTVQETEQADEALARLSFIPAVIVQGHRWLFVLSTRQGYKTILWKEWQFGTYGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7YGS5</accession>
    <name>C7YGS5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TspO/MBR-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_102365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TspO/BZRP family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054224.1">
        <property type="nucleotide sequence ID" value="XM_003054178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YGS5"/>
    <dbReference type="STRING" id="660122.C7YGS5"/>
    <dbReference type="GeneID" id="9676837"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102365"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102365"/>
    <dbReference type="eggNOG" id="KOG3797">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091805_0_0_1"/>
    <dbReference type="InParanoid" id="C7YGS5"/>
    <dbReference type="OMA" id="WSWLFFG"/>
    <dbReference type="OrthoDB" id="8841220at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033013">
        <property type="term" value="P:tetrapyrrole metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15904">
        <property type="entry name" value="TSPO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.100:FF:000001">
        <property type="entry name" value="translocator protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.100">
        <property type="entry name" value="TspO/MBR protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038330">
        <property type="entry name" value="TspO/MBR-related_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004307">
        <property type="entry name" value="TspO_MBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057">
        <property type="entry name" value="PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057:SF0">
        <property type="entry name" value="TRANSLOCATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03073">
        <property type="entry name" value="TspO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005859">
        <property type="entry name" value="PBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU48511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="20374" checksum="69552094EF078F65" modified="2009-10-13" version="1">MTTYVPALTLPDAVFLKPAVSVLLPIGLGTAVGLSATQTQKTYLSLKKPSVYPPPWLFGPVWTVLYGVMGYAAYRAANIGLSPFSSPDTIRTARHAMTLYSVQLGLNLLWTPLFFGLHRPIEASVDIITLVGVNGYLTYLYSSIDSVAAWCQVPYLGWLSFATYLCTSIGYLNNWDLSGKEVPKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHA0</accession>
    <name>C7YHA0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vacuolar transporter chaperone complex subunit 4</fullName>
            <ecNumber evidence="3">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Polyphosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">SPX-dependent polyphosphate polymerase VTC subunit 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Vacuolar membrane polyphosphate polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">NECHADRAFT_90133</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19574"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the VTC4 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="3"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054310.1">
        <property type="nucleotide sequence ID" value="XM_003054264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YHA0"/>
    <dbReference type="FunCoup" id="C7YHA0">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YHA0"/>
    <dbReference type="GeneID" id="9664466"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90133"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90133"/>
    <dbReference type="eggNOG" id="KOG1161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4580">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009308_0_0_1"/>
    <dbReference type="InParanoid" id="C7YHA0"/>
    <dbReference type="OMA" id="NVNAYMR"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016237">
        <property type="term" value="P:microautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07751">
        <property type="entry name" value="PolyPPase_VTC4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14480">
        <property type="entry name" value="SPX_VTC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.100.30:FF:000001">
        <property type="entry name" value="Vacuolar transporter chaperone 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="675"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="702"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="744"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="17">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="502"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="517"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEU48597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="771" mass="88458" checksum="F12426143E2B59E2" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHD4</accession>
    <name>C7YHD4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_74932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053612.1">
        <property type="nucleotide sequence ID" value="XM_003053566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YHD4"/>
    <dbReference type="GeneID" id="9664482"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74932"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74932"/>
    <dbReference type="eggNOG" id="ENOG502SG5H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050102_1_0_1"/>
    <dbReference type="InParanoid" id="C7YHD4"/>
    <dbReference type="OMA" id="ENEWTTV"/>
    <dbReference type="OrthoDB" id="4207724at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU47899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="408" mass="44435" checksum="1AEB7E90341E0917" modified="2009-10-13" version="1">MSDDMSMLYTIAGYIAIFGVGYVAYHYSSQKHQAKVAPVRPAKSQQAEPRKEDRKKKQRMETFASEAQEASKKASKAKEEVKAPETTAWLSNSNDKDEADNREFARQLAKAKEGTKLATKADSGKQREKSVKQSRANKMAGATEDKESAPSSTTGADADDDQSPVTSPEVGPAVAVAGDVSDMLEAASARPSILRLTDTEEKKSNKKAPKAAAPVETKKQRQNRKKAEAAKAAREEAEKQRKVLEEKQRRTARVAEGRAAKDGSQFMAAQAAKSVWKEGAPKAPEAPKTNGFHQPLDTYEEAPAKAVNAPKPAGNNWTESLPSEEEQIEMLKENDDEWSTVKTKSKKASKKAPSVESSDEPSARPAAQPQQPIGNKAAKPTQSFGSFSALTNKNDVADEEEEEEEWDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHN9</accession>
    <name>C7YHN9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_57487</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054384.1">
        <property type="nucleotide sequence ID" value="XM_003054338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YHN9"/>
    <dbReference type="STRING" id="660122.C7YHN9"/>
    <dbReference type="GeneID" id="9664615"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_57487"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_57487"/>
    <dbReference type="eggNOG" id="ENOG502QT9R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009159_0_0_1"/>
    <dbReference type="InParanoid" id="C7YHN9"/>
    <dbReference type="OMA" id="FPRIAFN"/>
    <dbReference type="OrthoDB" id="2373987at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056337">
        <property type="entry name" value="LHD_YVC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF1">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23190">
        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="671"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="699"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="770"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="826"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="882"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="912"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="3">
        <location>
            <begin position="31"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="YVC1 N-terminal linker helical" evidence="4">
        <location>
            <begin position="429"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="5">
        <location>
            <begin position="646"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1004"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1075"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1082"/>
            <end position="1095"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU48671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1117" mass="127142" checksum="87DCF1B61D7A16BE" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJ27</accession>
    <name>C7YJ27_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chromate ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_32022</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053909.1">
        <property type="nucleotide sequence ID" value="XM_003053863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJ27"/>
    <dbReference type="GeneID" id="9663691"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_32022"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_32022"/>
    <dbReference type="eggNOG" id="ENOG502QRJG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018106_0_2_1"/>
    <dbReference type="InParanoid" id="C7YJ27"/>
    <dbReference type="OMA" id="GMEPFWV"/>
    <dbReference type="OrthoDB" id="2160638at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014047">
        <property type="entry name" value="Chr_Tranpt_l_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33567">
        <property type="entry name" value="CHROMATE ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33567:SF3">
        <property type="entry name" value="CHROMATE ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004810">
        <property type="entry name" value="ChrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="210"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU48196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="54542" checksum="97801BC18E5A0573" modified="2009-10-13" version="1">MTNHDRGCVPVERLGSTVRQNWHMGFTSFGGPPVHFKIFYDKFTVKLQWLDEQVYQELFSVCQALSGPASTKMHYCINLIHDGFWSAILGFFIWSLPGAIGMYALSIGVSNIGESLPRQVYALLSGLNAATVGIIVLAAVQLSQKAITDRMTRVVVFLSASAGMLYNALWYFPVLMVLCGVATVIHDYRWLHGPVKKIASLVKRQRRREEEAAIEMPNSESVRVDQGTSTEAGEPAASRRSNTSARDQDRTSQEASMLSTAEEPRVIPQGRILNMSWKLGLFIIGLFFTSFIVVMVLRGTIPDMPLLYSLFANMYLAGTIIFGGGPVVIPLLREYVVAEGWVSPRDFLIGLALIQAFPGPNFNFAVYLGSLTAINGGYSSVAGALIGFIGIFFPGLVLVHGTMGLWSTIRQWRWVKAAVRGVNAAAVGLIYTAVYRLWQIGYIDEGYRNGTSLAVEPWWVVTTATSFFGSMWLGVSPPVAIVTGGAMGMVWYGIVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7YKQ3</accession>
    <name>C7YKQ3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_103121</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053489.1">
        <property type="nucleotide sequence ID" value="XM_003053443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YKQ3"/>
    <dbReference type="FunCoup" id="C7YKQ3">
        <property type="interactions" value="154"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YKQ3"/>
    <dbReference type="GeneID" id="9664288"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_103121"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_103121"/>
    <dbReference type="eggNOG" id="KOG2058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029367_3_0_1"/>
    <dbReference type="InParanoid" id="C7YKQ3"/>
    <dbReference type="OMA" id="MEGVHKG"/>
    <dbReference type="OrthoDB" id="10263206at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031030">
        <property type="term" value="P:negative regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000026">
        <property type="entry name" value="Mitotic check point protein (Bub2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF263">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="174"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU47776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="481" mass="51970" checksum="04917FB689BC9565" modified="2009-10-13" version="1">MSEPSSNASNASSTKPAIPSLPASITTQLQPPPSPRTHRVLRRLQSAHTLRPQNPPSLISQQRLRETQTQRNVSPTRSSPVPGAGPSASSGPPMSINRSPQRGRANSDATPPLIHQMNVVTASKRAGSKKPVFSHGHLSLQQIIREGPTDGDFLGALESARWKVIDGGVKSAEDGMSTLRIYVWLVLLDAPILSTDDYLALIHRGASPAYSKIRNDTFRTLTTDPLFRRRVSEASLIRLLNAIAWKLHDAREEQRQSRPSSSRASLPGDSASGHSQASTSSPTARNRARALTLTTEGSESGAGATTLEPGTYVQGMNVLAAPFLYAARSEAEAFVAFHSLLTRECPGYIRGAMDGVHRGLALVDKVLAIVDPKLSMYLTAKGLSAEIYAFPSVLTLCACTPPLPEVLRLWDFLFAYGPHLNIVCIVAQLTIMRSQILQSPSPNKVLRSFPQLNADLVKSVTIGIIKKIPDDVYAEIVSHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7YKT9</accession>
    <name>C7YKT9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RTA1 like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_35141</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052850.1">
        <property type="nucleotide sequence ID" value="XM_003052804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YKT9"/>
    <dbReference type="FunCoup" id="C7YKT9">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="GeneID" id="9670918"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_35141"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_35141"/>
    <dbReference type="eggNOG" id="ENOG502RKV7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033465_3_1_1"/>
    <dbReference type="InParanoid" id="C7YKT9"/>
    <dbReference type="OMA" id="YLYTHEW"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU47137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="30028" checksum="4F5F51D234D69DA7" modified="2009-10-13" version="1">MANNPWTYDPSPVAAIIFLLLFTVATLWHAVLLFTRKTWYFIPLVIGGALEIAGYVTRYLGSKDLENLTFFIIQTLVILVAPALLAASIYMVLGRLVVLVRAEAYLPVRPTWLTKIFVGGDILSFIIQIAGSGMLSSNFSLGKAIILVGLAIQLIFFGLFVFSAALFYRRLDANPTPTTFRLDAYSSKGGWRGVMQVLFLTSALIFIRSVFRFVEFTGDHDSPMMTSEAYIYICDSLLMFGVMAALIYLHPSEYIRTPKDMNSLEGEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C7YL56</accession>
    <name>C7YL56_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_102467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052912.1">
        <property type="nucleotide sequence ID" value="XM_003052866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YL56"/>
    <dbReference type="GeneID" id="9670976"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102467"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102467"/>
    <dbReference type="HOGENOM" id="CLU_2139428_0_0_1"/>
    <dbReference type="InParanoid" id="C7YL56"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU47199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="113" mass="13604" checksum="8EB1B50452B06751" modified="2009-10-13" version="1" fragment="single">KNTIYTQLHQNGHHYCYQRLPQLHLRAPLLHLRNCLRSHPLRHRNTPRLCARPLQPHRRRHFRSGRRRRRRGQVCCRQCCYSCCWRHRGFCLCEIHGAGTASCEQEDPVKCQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7YL83</accession>
    <name>C7YL83_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zinc-binding loop region of homing endonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_77439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052457.1">
        <property type="nucleotide sequence ID" value="XM_003052411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YL83"/>
    <dbReference type="GeneID" id="9670989"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77439"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77439"/>
    <dbReference type="eggNOG" id="ENOG502RVWG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_465465_0_0_1"/>
    <dbReference type="InParanoid" id="C7YL83"/>
    <dbReference type="OrthoDB" id="5106835at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.75.10">
        <property type="entry name" value="Homing Intron 3 (I-ppo) Encoded Endonuclease, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008704">
        <property type="entry name" value="Endonuclease_Zinc-binding_loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044930">
        <property type="entry name" value="Homing_endonuclease_His-Me"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05551">
        <property type="entry name" value="zf-His_Me_endon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc-binding loop region of homing endonuclease" evidence="1">
        <location>
            <begin position="431"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU46744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="586" mass="66182" checksum="89527E20334E9AA0" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLD0</accession>
    <name>C7YLD0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_77486</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052478.1">
        <property type="nucleotide sequence ID" value="XM_003052432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YLD0"/>
    <dbReference type="GeneID" id="9671010"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77486"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77486"/>
    <dbReference type="HOGENOM" id="CLU_824093_0_0_1"/>
    <dbReference type="InParanoid" id="C7YLD0"/>
    <dbReference type="OrthoDB" id="5099426at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988466" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="27"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU46765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="36429" checksum="3BA918379B0BFA3A" modified="2009-10-13" version="1">MLSYWHSNMWFLYFLLWQVLSVGCLSRDTSTATEIVLFPFPEGSPIDVHSSTASVESDAPWSESPFTKVWNDDQEGDEESTTGNFFGIISTISLAPQTSLEDAWSSETVTHEDETGFSTVTLVDEDSTTLSETETANETNAKTTFEIPTLELPSVSSSSTGSSHSFTTIPRATTTAEESPTPETTTAVPGTAPGLSAGQIIGIVTGTIASLVVVIVVILLFLLYRRRKHQAASRRPTIRLVGGPDPDPTERGSQIYLPVMQRQVVDSRDLLAGGVRRSGSPSRRSDRTVSELSPSEAAEGRDTIDGIVDGYTSSVYSQQSERGESRGGARSYADFSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7YMJ6</accession>
    <name>C7YMJ6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_92004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053172.1">
        <property type="nucleotide sequence ID" value="XM_003053126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YMJ6"/>
    <dbReference type="GeneID" id="9664088"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_92004"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_92004"/>
    <dbReference type="eggNOG" id="KOG4754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039184_1_0_1"/>
    <dbReference type="InParanoid" id="C7YMJ6"/>
    <dbReference type="OMA" id="HDKITHL"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF54">
        <property type="entry name" value="PHOSPHATASE SPAC5H10.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU47459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="28357" checksum="F5915C42EC210DB0" modified="2009-10-13" version="1">MAPTIHLVRHAQGFHNLSIENEQLSDPDLTPLGEEQCAALRAAFPHHDKLTKLLASPMRRTVYTCLHAFGTESLLPITALPVFQEVSAQPCDIGSPVAKVKAEFEGKADYTGVEEAWCEKGPSSKYQPTLEKLTVRGKEARRTLREIAGTGDEHIVVVSHGGFLHFLTDDWHGVPDGRATGWSNCEFRSYQFVDPTGEDEDAALRETEESWQRREGNTIAPTQTEQRELRPIVLEKMAPYLNLSVPNGKLQTVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7YMP2</accession>
    <name>C7YMP2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NECHADRAFT_67557</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix. Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing. It also suppresses a variety of mitochondrial intron mutations and its absence may disturb the assembly of mitochondrial membrane complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homopentamer. Forms homooligomers. Interacts with MFM1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052698.1">
        <property type="nucleotide sequence ID" value="XM_003052652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YMP2"/>
    <dbReference type="FunCoup" id="C7YMP2">
        <property type="interactions" value="332"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YMP2"/>
    <dbReference type="GeneID" id="9664110"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_67557"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_67557"/>
    <dbReference type="eggNOG" id="KOG2662">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025144_2_0_1"/>
    <dbReference type="InParanoid" id="C7YMP2"/>
    <dbReference type="OMA" id="EKTHDLY"/>
    <dbReference type="OrthoDB" id="10251508at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045016">
        <property type="term" value="P:mitochondrial magnesium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000005">
        <property type="entry name" value="Inner membrane magnesium transporter MRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.330:FF:000002">
        <property type="entry name" value="Inner membrane magnesium transporter mrs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039204">
        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF0">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU46985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="533" mass="60901" checksum="08D1A8DDD557BB85" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C7YN31</accession>
    <name>C7YN31_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_78088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052767.1">
        <property type="nucleotide sequence ID" value="XM_003052721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YN31"/>
    <dbReference type="GeneID" id="9671299"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78088"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78088"/>
    <dbReference type="HOGENOM" id="CLU_1993211_0_0_1"/>
    <dbReference type="InParanoid" id="C7YN31"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU47054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="125" mass="13853" checksum="BF8B389F998EAB3B" modified="2009-10-13" version="1">MSTLQVLVGDESSYSHTLKMRTALHPCNPTKVHGTCSEKKERTKPWVTFNLGNGMFRKYICFFSSSEAPPLFTHTPSQTMDKDSGPDPKAVKVLGAADGRVPAPYVQIRKDNLRGCEWGHTVSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNL2</accession>
    <name>C7YNL2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_79345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052302.1">
        <property type="nucleotide sequence ID" value="XM_003052256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNL2"/>
    <dbReference type="GeneID" id="9672859"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79345"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79345"/>
    <dbReference type="HOGENOM" id="CLU_174195_0_0_1"/>
    <dbReference type="InParanoid" id="C7YNL2"/>
    <dbReference type="OMA" id="RMLYIRC"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU46589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="109" mass="12113" checksum="98F3424763039881" modified="2009-10-13" version="1">MERGEGQNGREEAWEKKVTLGFMGMVSSSFYTSTPSLSSHKSVTPFSLSSGISLTSTNSRMLYMRCLLQYSSSSTRRSRSISSIKRSSSSDEESPSPVDAPRRHKRPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNU7</accession>
    <name>C7YNU7_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_100235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052350.1">
        <property type="nucleotide sequence ID" value="XM_003052304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNU7"/>
    <dbReference type="GeneID" id="9670872"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100235"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100235"/>
    <dbReference type="eggNOG" id="ENOG502STYS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058869_0_0_1"/>
    <dbReference type="InParanoid" id="C7YNU7"/>
    <dbReference type="OMA" id="SHPPGYQ"/>
    <dbReference type="OrthoDB" id="5385910at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU46637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="244" mass="24770" checksum="D2B643C9E012DDE6" modified="2009-10-13" version="1">MPPVPIYTASPITAAKASGITPQTAHSDDPEASAGAPNTTDSPTSTYPAAQPGARPSMPAPTGVPHHSADVQPTPTQAAVDASPPAPQPGAVPTPPSYLPPPPKTGETMHGTQAQATEVPMPPQMSYAPVGGSEFAAQHSSTTTAPGSSPMVGLGSTSGLGGPSGSDFSHPPGYHQNVHASEFSSSQRAAHELALAQDNRRPSLSLMGDEDGDGVWQAAKKWASAAGDSLAAAEHEVWKRINKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPM0</accession>
    <name>C7YPM0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Multicopper oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">NECHADRAFT_38678</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cell membrane</location>
            <topology evidence="16">Single-pass type I membrane protein</topology>
            <orientation evidence="16">Extracellular side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052032.1">
        <property type="nucleotide sequence ID" value="XM_003051986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YPM0"/>
    <dbReference type="FunCoup" id="C7YPM0">
        <property type="interactions" value="729"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YPM0"/>
    <dbReference type="GeneID" id="9668737"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_38678"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_38678"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_7_3_1"/>
    <dbReference type="InParanoid" id="C7YPM0"/>
    <dbReference type="OMA" id="WHSHTEH"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13851">
        <property type="entry name" value="CuRO_1_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13899">
        <property type="entry name" value="CuRO_3_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000022">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000024">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000025">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0186">Copper</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0410">Iron transport</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002986365" description="Multicopper oxidase" evidence="19">
        <location>
            <begin position="23"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="554"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="22">
        <location>
            <begin position="32"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="20">
        <location>
            <begin position="157"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="21">
        <location>
            <begin position="364"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="589"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="611"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00037814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EEU46319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="25">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="622" mass="68482" checksum="60C502C3F24CD9FA" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPM5</accession>
    <name>C7YPM5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ceramide very long chain fatty acid hydroxylase</fullName>
            <ecNumber evidence="16">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">NECHADRAFT_68157</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16 17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="16 17">Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the sterol desaturase family. SCS7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="16"/>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051586.1">
        <property type="nucleotide sequence ID" value="XM_003051540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YPM5"/>
    <dbReference type="FunCoup" id="C7YPM5">
        <property type="interactions" value="237"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YPM5"/>
    <dbReference type="GeneID" id="9673263"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_68157"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_68157"/>
    <dbReference type="eggNOG" id="KOG0539">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034756_0_1_1"/>
    <dbReference type="InParanoid" id="C7YPM5"/>
    <dbReference type="OMA" id="WTIIEYV"/>
    <dbReference type="OrthoDB" id="2204368at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080132">
        <property type="term" value="F:fatty acid 2-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000007">
        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014430">
        <property type="entry name" value="Scs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863:SF1">
        <property type="entry name" value="FATTY ACID 2-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863">
        <property type="entry name" value="FATTY ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005149">
        <property type="entry name" value="IPC-B_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15 16" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4 18" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16 18" id="KW-0408">Iron</keyword>
    <keyword evidence="3 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 16 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9 17" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="20">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="18">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="18">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR005149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EEU45873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="389" mass="44548" checksum="81EC06181CD34E05" modified="2009-10-13" version="1">MPSRTLPTFTRAEVEAHNSKTSCYVSIGNKVYDVTDFADDHPGGADLVLDYAGRDIKEILEDPDSHEHSEAAYDVLDDSLVGFLISEKSANGHANVHANGNGNANGNGVAKVANGDATTNGETYVHPRTGMSCAEDLSKDTDFDNDYKRHKFLDLSRPLFPQIWFGGFSKEFYLDQVHRPRHYKGGQSAPLFGNFLEPLSKTPWWVIPTVWGPCVMYAVYLASQGYDNQLYTAGYFAFGFWFWSIIEYVLHRFLFHLDYYLPDNRVGITLHFLLHGIHHYLPMDKYRLVMPPTLFVVLAYPFWHFAHAVFSYSWHAATGAFAGGLFGYICYDLTHYFLHHQNLPLWYKELKKYHLAHHFLDYELGFGVTSKFWDSIFGTELIYNVKKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQ28</accession>
    <name>C7YQ28_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Splicing factor 3B subunit 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_100028</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051665.1">
        <property type="nucleotide sequence ID" value="XM_003051619.1"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
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        </source>
    </evidence>
    <sequence length="792" mass="93695" checksum="CB7D0451ADAD963F" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQK6</accession>
    <name>C7YQK6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_38413</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13 14">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051754.1">
        <property type="nucleotide sequence ID" value="XM_003051708.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="C7YQK6">
        <property type="interactions" value="861"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YQK6"/>
    <dbReference type="GeneID" id="9672667"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_38413"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_38413"/>
    <dbReference type="eggNOG" id="KOG1870">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001060_9_1_1"/>
    <dbReference type="InParanoid" id="C7YQK6"/>
    <dbReference type="OMA" id="KPRGCTG"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF24">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00695">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUSP" evidence="10">
        <location>
            <begin position="190"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="536"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="24"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="392"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="487"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1032"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1371"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1497"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1558"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1036"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1091"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1375"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1392"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1572"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU46041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1585" mass="173824" checksum="C6EBDA997550EB8A" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7YR55</accession>
    <name>C7YR55_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">H/ACA ribonucleoprotein complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nucleolar protein family A member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_69255</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050732.1">
        <property type="nucleotide sequence ID" value="XM_003050686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YR55"/>
    <dbReference type="FunCoup" id="C7YR55">
        <property type="interactions" value="1249"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YR55"/>
    <dbReference type="GeneID" id="9666505"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_69255"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_69255"/>
    <dbReference type="eggNOG" id="KOG3387">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084513_4_1_1"/>
    <dbReference type="InParanoid" id="C7YR55"/>
    <dbReference type="OMA" id="IKNQIYA"/>
    <dbReference type="OrthoDB" id="1924699at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000002">
        <property type="entry name" value="NHP2-like protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="11">
        <location>
            <begin position="18"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU45019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="124" mass="13462" checksum="7AF596841AB38786" modified="2009-10-13" version="1">MSESAAWPLADQKLEQELLDLVQSSQHARQLKKGANEATKTLNRGVSEIVILAADTQPLAILLHLPLLCEDKNVPYVYVSSKMHLGRACGVSRAVIAASITSNDASELAGQIRAMRDKVERLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRB3</accession>
    <name>C7YRB3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_40481</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051140.1">
        <property type="nucleotide sequence ID" value="XM_003051094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YRB3"/>
    <dbReference type="GeneID" id="9667835"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_40481"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_40481"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_3_1"/>
    <dbReference type="InParanoid" id="C7YRB3"/>
    <dbReference type="OMA" id="MAWCFFA"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF30">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04702)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="51"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="252"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU45427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="546" mass="59677" checksum="08066C991A7F82D2" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7YS84</accession>
    <name>C7YS84_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_80647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051304.1">
        <property type="nucleotide sequence ID" value="XM_003051258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YS84"/>
    <dbReference type="GeneID" id="9666161"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_80647"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_80647"/>
    <dbReference type="eggNOG" id="ENOG502SRIZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036928_0_0_1"/>
    <dbReference type="InParanoid" id="C7YS84"/>
    <dbReference type="OMA" id="RWHVREL"/>
    <dbReference type="OrthoDB" id="3644718at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU45591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="576" mass="65746" checksum="FC224CF9923EFD71" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSD5</accession>
    <name>C7YSD5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_41818</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EEU45229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_41818"/>
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    </dbReference>
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    <dbReference type="InParanoid" id="C7YSD5"/>
    <dbReference type="OMA" id="VKQIKLV"/>
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    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="entry name" value="STKc_Cdc7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DDB_G0283821-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="56"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="361"/>
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        <location>
            <begin position="424"/>
            <end position="482"/>
        </location>
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        <location>
            <begin position="519"/>
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        <location>
            <begin position="1190"/>
            <end position="1240"/>
        </location>
    </feature>
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        <location>
            <begin position="1253"/>
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        <location>
            <begin position="316"/>
            <end position="333"/>
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        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
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        <location>
            <begin position="1198"/>
            <end position="1218"/>
        </location>
    </feature>
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        <location>
            <begin position="1226"/>
            <end position="1235"/>
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            <begin position="1258"/>
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    </feature>
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        <location>
            <begin position="1305"/>
            <end position="1324"/>
        </location>
    </feature>
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        <location>
            <position position="85"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEU45229.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1386" mass="152231" checksum="61552407D0661B60" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>C7YTE6</accession>
    <name>C7YTE6_FUSV7</name>
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            <fullName evidence="11">2-oxoglutarate reductase</fullName>
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            <ecNumber evidence="5">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
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        <name evidence="16" type="ORF">NECHADRAFT_105233</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
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            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + NADH + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
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            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + NADH + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.399"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="F:NAD binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="D-2-hydroxyacid_DH"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
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        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PRK11790.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="15">
        <location>
            <begin position="400"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEU44607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="470" mass="51480" checksum="AA98AD02E809D6A8" modified="2009-10-13" version="1">MTQVSELGRRSLHVDSEAGWDQNLSTSPVASFHSPPPSWAANLPSRGGAPKVLKPFNSQDIKILLLENVNVTGQEILRAQGYQVEALKTSLPEDQLIEKIREVQVIGIRSKTKLTEKVLREAKNLLVIGCFCIGTNQVDLDYAARNGIAVFNSPFANSRSVAELVIAEIITLARQLGDRSNEMHRGTWNKVSAKCWEIRGKTLGIVGYGHIGSQLSVLAEAMGMNVIYYDVVTLMALGTASQVPTLEKLLQEADFVSLHVPDLPETRNMISGPQFDQMKTGAYLINASRGSVVDIPALIKASRTGKIAGAAIDVFPQEPAANGDYFTNDLNTWGEDLRSLKNLILTPHIGGSTEEAQRAIGIEVSEALVRYINQGTTLGSVNVPEVQMRSLTLDESDTARVIFIHRNVPGVLRKVNEILGDHNVDKQISDSRGDVAYLMADVSSVKYEQIKDIFDSLEALSSRIMTRVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7YTG8</accession>
    <name>C7YTG8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ilp is an apoptosis inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_84577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049957.1">
        <property type="nucleotide sequence ID" value="XM_003049911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YTG8"/>
    <dbReference type="STRING" id="660122.C7YTG8"/>
    <dbReference type="GeneID" id="9665736"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84577"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84577"/>
    <dbReference type="eggNOG" id="ENOG502S2F8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079969_0_0_1"/>
    <dbReference type="InParanoid" id="C7YTG8"/>
    <dbReference type="OMA" id="FEWYPHY"/>
    <dbReference type="OrthoDB" id="5335812at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053267">
        <property type="entry name" value="Verrucosidin_biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42087">
        <property type="entry name" value="ILP IS AN APOPTOSIS INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42087:SF1">
        <property type="entry name" value="ILP IS AN APOPTOSIS INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU44244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="20278" checksum="E33025A7D9EEC6EC" modified="2009-10-13" version="1">MSMQFQSPFQESQFDIFEWYPQFQSCLRYFIDHAQYSAPVQTVAACVNILLPFQKGTSPPVTPTRSGPVTGFDSPAVLHGFFGDDWLQGIGPVHESERRNYLFAAKSDNWLKVKSQYDMADGQTVPFLRPLQNVTEEEIQAAESNWSEWLAMQDWMLGPRAPPDVGDRRVRVKKEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWE0</accession>
    <name>C7YWE0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein L31e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_73333</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU43941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049654.1">
        <property type="nucleotide sequence ID" value="XM_003049608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWE0"/>
    <dbReference type="FunCoup" id="C7YWE0">
        <property type="interactions" value="907"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YWE0"/>
    <dbReference type="GeneID" id="9677477"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_73333"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_73333"/>
    <dbReference type="eggNOG" id="KOG0893">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112570_1_1_1"/>
    <dbReference type="InParanoid" id="C7YWE0"/>
    <dbReference type="OMA" id="EVWKQGI"/>
    <dbReference type="OrthoDB" id="9739313at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.440.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU43941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="13934" checksum="28CA04E910777B4A" modified="2009-10-13" version="1">MSSKKPSGKTQRSAIADVVAREYTIHMHKRLHGVTFKKRAPRAIKEIKSFATKAMGTSDVRIDPQLNKKVWENGVKGVDYRLRIRISRRRNDEEGAKEKLYSYVQAVNVKDPKGLPTVLVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWG9</accession>
    <name>C7YWG9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_74298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049890.1">
        <property type="nucleotide sequence ID" value="XM_003049844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWG9"/>
    <dbReference type="GeneID" id="9677488"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74298"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74298"/>
    <dbReference type="eggNOG" id="ENOG502RKP5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066904_0_0_1"/>
    <dbReference type="InParanoid" id="C7YWG9"/>
    <dbReference type="OMA" id="PHREHEK"/>
    <dbReference type="OrthoDB" id="4939498at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="395"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="61"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU44177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="426" mass="49004" checksum="72940A07B0CA6114" modified="2009-10-13" version="1">MPLHQRTSASPVKRSSSSASSTVSSKALTGAHNNARLFPLSHTDRRNTVHDYDYSYEYDYESDLRDDLQKANTDLNKANAENDKLKNTIETLTRKLNEAKTSLEQANRKATESNVSYREVKAQLEGARSEAEVLKEDNRRLNTDFEELKEDKRRLNSECEELKEEKETLKEENERVKFEHHDLEQRFIGLTAKHENLTMRFNALNNNQTPTSTMTSPMSSPMPSPLPAALPEATRKPSRPSSKASSKASSKPSSKTGSKRETREAREERHREREERHQSEREESSREERPREHRHRDERTREERREDRGRRSDKPKDKDSRPDIKADKERLSKRFDERPASGPRQTSFIEPWGPGGWSHYDTPSNNLDAYGQMTTGRKAASVVSSQATYNVPRTSSIVNGHFSSDSSTYDDERYEDGSYHAYPIPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWP0</accession>
    <name>C7YWP0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_89855</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049929.1">
        <property type="nucleotide sequence ID" value="XM_003049883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWP0"/>
    <dbReference type="STRING" id="660122.C7YWP0"/>
    <dbReference type="GeneID" id="9674541"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89855"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89855"/>
    <dbReference type="eggNOG" id="KOG0259">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_4_1"/>
    <dbReference type="InParanoid" id="C7YWP0"/>
    <dbReference type="OMA" id="SKSYNMG"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510:SF1">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="58"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU44216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="397" mass="43470" checksum="2138C00AA78E8CE5" modified="2009-10-13" version="1">MVRITPFAVEQWMDKYETTPDVLNIAETCAASVSIDDLVGLSKDPAAPGPIDTSIKLTYGPIPGTRTLRERIAAHCSTEETKLAAEDIIITQGAIGANFLSLYTLVGPGDHVVCVYPTYQQLYDVPRSVGAEVTLWKLRAEEGFVPNVDELTSLIKENTKMIIINNPNNPTGAPISTDIVQRIARVAEEKGIILFSDEVYRPLFHGGALGEIEVPLPATTLGYQKTVVTGSMSKGYALAGIRVGWIASRDKSIISAIMSARDYTTISVSQIDDRIASYALSPAVRPSLVERNMTLARTNAKLVKEFVERHQSVCSWVEPRAGTTAFIRFTKNGEPVDDVDFCLDLLDKTKILFCAGSRCFGGDEDFKGYVRMGYVCETDVLVEGLKRLGDYIDNNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWT8</accession>
    <name>C7YWT8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_82780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049175.1">
        <property type="nucleotide sequence ID" value="XM_003049129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWT8"/>
    <dbReference type="STRING" id="660122.C7YWT8"/>
    <dbReference type="GeneID" id="9666563"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82780"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82780"/>
    <dbReference type="eggNOG" id="ENOG502QRIX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028760_5_0_1"/>
    <dbReference type="InParanoid" id="C7YWT8"/>
    <dbReference type="OMA" id="GWYGADF"/>
    <dbReference type="OrthoDB" id="191364at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001209">
        <property type="entry name" value="PRK00175.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF11">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="60"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU43462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="444" mass="48585" checksum="31C65CF90C702E63" modified="2009-10-13" version="1">MASKAILLGSNPDTKNYYANLVNDQRYALIPRLELETGQSLNNCPIAYQTWGSLNKEGDNALVVCHALTGSSDVADWWNPLIGPRKALDPRYYFIFCGNVLGSPYGSASPVTANPATGRCYGTDFPSTTIRDDVHAHKLVLDALGVRQIAAVIGGSMGGMATLEWPLCTPQGYVRNIIPIATAADHSAWGISWAETQRQCIYADPKFKDGHYEPVPEGQPSAGLAAARMIAMLTYRSCTSFDSRFGRKPQRHTKLATSSQLDIDNSKKPFGDYQNKEHVAVKGRKEKIAFSAQGYLHYQGEKFIKRFDANCFLHLSNKMDSHDVTRNRTTQPGTGALQGVLGNIPTGALVVSVESDALFVPEQQEKLAACLPEASLEILESSDGHDGFLLEFEQLDRLIQAKLKTALPHLYSYVVPSNLVSAPKATQNTTATEKSLVGETDGWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7YX77</accession>
    <name>C7YX77_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_82920</name>
        <name evidence="4" type="ORF">NECHADRAFT_89559</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">77-13-4</strain>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699097">
        <property type="protein sequence ID" value="EEU33353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039066.1">
        <property type="nucleotide sequence ID" value="XM_003039020.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049249.1">
        <property type="nucleotide sequence ID" value="XM_003049203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YX77"/>
    <dbReference type="STRING" id="660122.C7YX77"/>
    <dbReference type="GeneID" id="9667216"/>
    <dbReference type="GeneID" id="9676928"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82920"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89559"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82920"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89559"/>
    <dbReference type="eggNOG" id="ENOG502SPG6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036632_5_0_1"/>
    <dbReference type="OMA" id="KCFNIVA"/>
    <dbReference type="OrthoDB" id="3918601at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="3">
        <location>
            <begin position="35"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU33353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU43536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="390" mass="42607" checksum="7B58E35E01CB71E4" modified="2009-10-13" version="1">MILPREHETPFNKAPLIRAVTALLMVISILSAITRLVTRMATAGNLKLDDILVGASTKIMAIAQSIAVIIQGANGLGKMQGLSADQVSSILKAQYTSDVLFILTLLLAKISATRTIWGMAPRKRRGLIWATEGMIGAWALSSIAASFFQCSIPEPWDYVEGQCFNRYAFWVYVDALNIITDLAITSILVDMFIHLKTSVAKKTLVIGVFGCRTFIIPPIICHMYYYKAATESNNPIFDMWPPTIITQVILCLSVMATCIPYLKPFLDSLESGQMIAGDLRGASSKGSNSRSRSGPSGYASASAHTTRPRDKSARGIMSVADMASNASYRRQNYEMMDMGKSRDRGNQATVTAASEANGSWDRHSQTSQTVLVEQSWTVDVHRERSGTTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXB0</accession>
    <name>C7YXB0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RTA1 like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_45506</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049269.1">
        <property type="nucleotide sequence ID" value="XM_003049223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXB0"/>
    <dbReference type="GeneID" id="9676941"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45506"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45506"/>
    <dbReference type="eggNOG" id="ENOG502QU4U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033465_6_1_1"/>
    <dbReference type="InParanoid" id="C7YXB0"/>
    <dbReference type="OMA" id="WIFIGVD"/>
    <dbReference type="OrthoDB" id="4521223at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF8">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU43556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="32201" checksum="6A47579640D67E14" modified="2009-10-13" version="1">MAPEPQFCTDITPECLKYTIYGYRPNLGVNAFFVAFFAVCFAANIWLGIRYRIKGYAIALALGCLAMVLGYLSRLGLYFRPFDSMPFQAQVCCLIISPAFNSAAVYLMLKYLVELFGPECSILKPKQYTIVFVTADIISLVLQATGGGIAATAGSDKDMLELGNNIMMAGIAFQVVTLSIFAILSVLFLVRRIAARPVDPLSGTALEAWRSMRFRLFLFGLITAFTAIYIRCVYRIAEMRGGWGNELMKDETAFIILEGFMMLIATLSQTALHPGLLFPAMLGPQMKSSTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYD8</accession>
    <name>C7YYD8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_47217</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU42989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048702.1">
        <property type="nucleotide sequence ID" value="XM_003048656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYD8"/>
    <dbReference type="GeneID" id="9665805"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_47217"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_47217"/>
    <dbReference type="eggNOG" id="ENOG502SHH3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062674_0_1_1"/>
    <dbReference type="InParanoid" id="C7YYD8"/>
    <dbReference type="OMA" id="WNSNMYL"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040085">
        <property type="entry name" value="MJ0674-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43075">
        <property type="entry name" value="FORMATE LYASE ACTIVATING ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43075:SF1">
        <property type="entry name" value="FORMATE LYASE ACTIVATING ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01099">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="112"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU42989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="361" mass="40511" checksum="ADB450DC96374BC9" modified="2009-10-13" version="1">MLFLSRQCATRSFRIRSLPAIGHRRSLHLAPPFLLDDYIPRYQTLSSRDVAKKRSLAYAHLRNCNLCPRECGVNRYEKTGMCLIGEKVKVNTIAPHFGEEPCIQGHTGSGSVFMSGCNLRCIFCQNFDISHQRNGMDLTPEDLGDWYMKLQEVGNVHNINIVTPEHVVPQVALSILHARDRGLMVPIVYNTSSFDSLASLELMDGLVDIYLADFKVWEPSTSKRLLKADDYATTARESVKAMHAQVGDLCFTGDGIAKSGLLIRHLVMPGKEAEGAEIMRFLAKEVSRDCFVNIMEQYHPDAHVGKKKRGKTKDGEADNEVRYADINRAVTDQEISSIRKAAMDAGLWRFNDPPKHDGFAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZ61</accession>
    <name>C7YZ61_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Clustered mitochondria protein homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Protein TIF31 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CLU1</name>
        <name evidence="3" type="synonym">TIF31</name>
        <name evidence="7" type="ORF">NECHADRAFT_101351</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">May associate with the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CLU family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049023.1">
        <property type="nucleotide sequence ID" value="XM_003048977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZ61"/>
    <dbReference type="FunCoup" id="C7YZ61">
        <property type="interactions" value="1003"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YZ61"/>
    <dbReference type="GeneID" id="9665683"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101351"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101351"/>
    <dbReference type="eggNOG" id="KOG1839">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003256_2_0_1"/>
    <dbReference type="InParanoid" id="C7YZ61"/>
    <dbReference type="OMA" id="HPVWDKD"/>
    <dbReference type="OrthoDB" id="1414216at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd15466">
        <property type="entry name" value="CLU-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000293">
        <property type="entry name" value="Clustered mitochondria protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2280.10:FF:000002">
        <property type="entry name" value="Clustered mitochondria protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2280.10">
        <property type="entry name" value="Hypothetical protein (hspc210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03013">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028275">
        <property type="entry name" value="CLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15044">
        <property type="entry name" value="CLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Clu" evidence="6">
        <location>
            <begin position="324"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="1000"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="612"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="892"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1209"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="612"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="645"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="892"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1209"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1247"/>
            <end position="1266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU43310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1266" mass="139893" checksum="FFF7596D18AB5E1A" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZR6</accession>
    <name>C7YZR6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_47446</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048367.1">
        <property type="nucleotide sequence ID" value="XM_003048321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZR6"/>
    <dbReference type="GeneID" id="9667636"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_47446"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_47446"/>
    <dbReference type="eggNOG" id="KOG4369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002406_2_0_1"/>
    <dbReference type="InParanoid" id="C7YZR6"/>
    <dbReference type="OMA" id="YKCSKPW"/>
    <dbReference type="OrthoDB" id="21416at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="4">
        <location>
            <begin position="283"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="898"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="203"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU42654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1118" mass="127444" checksum="463A1689B47B417C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z003</accession>
    <name>C7Z003_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amine oxidase</fullName>
            <ecNumber evidence="9">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_84204</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="9">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="8">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8 9">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="9"/>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048597.1">
        <property type="nucleotide sequence ID" value="XM_003048551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z003"/>
    <dbReference type="STRING" id="660122.C7Z003"/>
    <dbReference type="GeneID" id="9667493"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84204"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84204"/>
    <dbReference type="eggNOG" id="KOG1186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011500_3_1_1"/>
    <dbReference type="InParanoid" id="C7Z003"/>
    <dbReference type="OMA" id="IWHTYGL"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF33">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0186">Copper</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="11">
        <location>
            <begin position="262"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="629"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="629"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="7">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="8">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU42884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="654" mass="73921" checksum="931736DE8DD866A6" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z016</accession>
    <name>C7Z016_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_84217</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048605.1">
        <property type="nucleotide sequence ID" value="XM_003048559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z016"/>
    <dbReference type="GeneID" id="9667682"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84217"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84217"/>
    <dbReference type="eggNOG" id="ENOG502RMDF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164184_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z016"/>
    <dbReference type="OMA" id="PCSFCVK"/>
    <dbReference type="OrthoDB" id="2269373at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF85">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="90"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU42892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="129" mass="14745" checksum="05666A8D611CF491" modified="2009-10-13" version="1">MAALPTEQPSRPTESKRILACVLCQQRKKKCDRKSPCSFCIKAKVTCIPSTPAPKRKRRKPTKELLERLERCEQLLKRCTCVQKSQMYDMPGHYSESSSSPTDSHSSPPPEYEKVTPSSYEQHQTFSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0W9</accession>
    <name>C7Z0W9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor 25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_93314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048171.1">
        <property type="nucleotide sequence ID" value="XM_003048125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0W9"/>
    <dbReference type="STRING" id="660122.C7Z0W9"/>
    <dbReference type="GeneID" id="9667343"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_93314"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_93314"/>
    <dbReference type="eggNOG" id="KOG2422">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008321_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z0W9"/>
    <dbReference type="OMA" id="IWGKMPP"/>
    <dbReference type="OrthoDB" id="205993at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006994">
        <property type="entry name" value="TCF25/Rqc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684">
        <property type="entry name" value="NULP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684:SF0">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT TCF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04910">
        <property type="entry name" value="Tcf25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="698" mass="78959" checksum="B50A4394C8A2427C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1U3</accession>
    <name>C7Z1U3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_85916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU41883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047596.1">
        <property type="nucleotide sequence ID" value="XM_003047550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1U3"/>
    <dbReference type="GeneID" id="9671560"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85916"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85916"/>
    <dbReference type="eggNOG" id="ENOG502RN1V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_819127_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z1U3"/>
    <dbReference type="OrthoDB" id="5080136at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU41883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="339" mass="37462" checksum="EE70232F66C687E7" modified="2009-10-13" version="1">MALTVRQAIGVGVAVGFAGSLILIAVTFGISRIISAYYVPPKRAIAMQPQPSPAILAPPPDAIKEMNIGVHAISGTAELKEAESFEYQFGNFTRVFFGRGLHGKPDVPESLFDESELVRLAGEPVNGGTWSQSISNVSTRDPAIRCFLAQVVYKRMQPTCPVDDCLLPPEVSSCYQLVCRVYDIPKRIRPIAAWRESILMLLDYPWSLEPLPCGPFEDGDPRKERVRAMVPAIVNALQPEALRTDHPRNDRFENHMADILERAANFAIVLLGQPTEWEAVWSSTKPGFIIYPGLSQSKEYAKSGVAEAPPHGSSQLREHKTAEHKTARDGTTLRFSLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z2X6</accession>
    <name>C7Z2X6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_87751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047272.1">
        <property type="nucleotide sequence ID" value="XM_003047226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z2X6"/>
    <dbReference type="GeneID" id="9676189"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87751"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87751"/>
    <dbReference type="eggNOG" id="ENOG502S6E5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022883_5_1_1"/>
    <dbReference type="InParanoid" id="C7Z2X6"/>
    <dbReference type="OMA" id="TICVWTA"/>
    <dbReference type="OrthoDB" id="5092703at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF9">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="481"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="510"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="540"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="593"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU41559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="645" mass="72308" checksum="E85C4592F044A4AA" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z482</accession>
    <name>C7Z482_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_70889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046982.1">
        <property type="nucleotide sequence ID" value="XM_003046936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z482"/>
    <dbReference type="STRING" id="660122.C7Z482"/>
    <dbReference type="GeneID" id="9675634"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_70889"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_70889"/>
    <dbReference type="eggNOG" id="ENOG502SRDH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011578_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z482"/>
    <dbReference type="OMA" id="GMYKKEK"/>
    <dbReference type="OrthoDB" id="3946750at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="744"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU41269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1052" mass="118595" checksum="54A9188C12DEB0F7" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z5R5</accession>
    <name>C7Z5R5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_32326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046280.1">
        <property type="nucleotide sequence ID" value="XM_003046234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z5R5"/>
    <dbReference type="GeneID" id="9678385"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_32326"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_32326"/>
    <dbReference type="eggNOG" id="KOG4754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039184_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z5R5"/>
    <dbReference type="OMA" id="NEQCRIL"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07040">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF54">
        <property type="entry name" value="PHOSPHATASE SPAC5H10.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU40567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="31002" checksum="FE05A9E23CDA5708" modified="2009-10-13" version="1">MSPVIHCIRHGQGFHNVGAGCYTLPDPRLTPLGEEQNMALRKTTFSDQSMISLILASPLCRTLQYAYLVFQPALAANSKCHPEIIAIPDAQETSDDPCDVGTDPSVLRAVVAESKWPADLSLVKEGWNVKALGTRYSPESNAIAARARDVRIFIRQKTRQLIEQGDTDPQVALVTHSGFLHYFTDDWEDSWLNPGTGWRNCETRSYVFKQDVMDDTDVEFMLTETMESRLRRGKGYPMPAGEEQTVLFEQAMENWESQGLQRPDRIGLHLETSVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z5T5</accession>
    <name>C7Z5T5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_75862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046292.1">
        <property type="nucleotide sequence ID" value="XM_003046246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z5T5"/>
    <dbReference type="GeneID" id="9678128"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75862"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75862"/>
    <dbReference type="HOGENOM" id="CLU_607043_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z5T5"/>
    <dbReference type="OrthoDB" id="2426273at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596:SF2">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G17550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU40579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="50954" checksum="E9FF00EC429E0E99" modified="2009-10-13" version="1">MSYVWSDGLGNPTANGLPQCQLELISTSISKGLTETSSLGNYRIKSVHIDPTQNKTGGVDNVKKLKSMAINQMGEIYAAAKQVLVLDSELQRAHSDVEDDVSNTELLARLWLIKQLLSKSREGRDDKEGEAAALRAPVLSYLRRRFQETLDDIICILPRHHGEWDDLAYRNTAMKEDLPAIFANLLNINAFKILQEDPSRRMQALLRSLYSLPVELLFNKGPFAEVGMDSLSRWVPSFPSKFKMGRSKEIRWTKDGDLEFSYLSYGHIREGDFLAVVFGGDTPRRDRTCSAFILPLFYREGDDILMELLVRLEYPDKDEMSRHDDCEEILILDRRPSPGVRTTPACSRGCLLRLLDQDDDSLWRGIDVTGQFDCPLTWTVASPDDLARYPRVPPKEAWRTFDLTVKCDRFREAGGTVVAGCGLCGAEPRWELVVVIFLGMGGQDIRPFVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6A0</accession>
    <name>C7Z6A0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_32302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046375.1">
        <property type="nucleotide sequence ID" value="XM_003046329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6A0"/>
    <dbReference type="STRING" id="660122.C7Z6A0"/>
    <dbReference type="GeneID" id="9668562"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_32302"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_32302"/>
    <dbReference type="eggNOG" id="ENOG502T39V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1067735_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z6A0"/>
    <dbReference type="OMA" id="IHPHTLH"/>
    <dbReference type="OrthoDB" id="4583914at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU40662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="261" mass="30844" checksum="229B9BF0A40C56F1" modified="2009-10-13" version="1" fragment="single">LFKGTPRECVVHLGPWEVQESKERRVIWQGANQNETLEHYFPSSEPSDLHPHTLHNRHRPYNDPADVERYITFQEPHRIRYINNEGVCMHDEFMDVKYEFSSAESSVQFQGDLRRKDLVDFYDTDVVWTNIHGRTNSFGNVRGVATLQRLKLWRDRLNGLYSLSIHQNNASRQYVNYNLEDFRAVTMPSDRAKKLRLEALHQDDDNGRRPVTENRRQLGRRGSEASESRLQRRPTDNIRYLAIQFSERTGNLPPLYQSYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z718</accession>
    <name>C7Z718_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_76280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046504.1">
        <property type="nucleotide sequence ID" value="XM_003046458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z718"/>
    <dbReference type="GeneID" id="9668851"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76280"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76280"/>
    <dbReference type="eggNOG" id="KOG2317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_5_3_1"/>
    <dbReference type="InParanoid" id="C7Z718"/>
    <dbReference type="OMA" id="RATYYIT"/>
    <dbReference type="OrthoDB" id="538640at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd06154">
        <property type="entry name" value="YjgF_YER057c_UK114_like_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43857">
        <property type="entry name" value="BLR7761 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43857:SF1">
        <property type="entry name" value="YJGH FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU40791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="138" mass="14986" checksum="A8C8116807909199" modified="2009-10-13" version="1">MVSRQNISSGSAFEAQIGYSRAVVTEDWVFVSGTTGYNYSTGDISPDVAEQADQTLANIAAALKDAGASVEDVVRVRYILPDRDDFPKTWPVLQKWFGHVRPAATMVQSALMKEEMKIEIEVTARKGCGNSTDQGPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7M5</accession>
    <name>C7Z7M5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_76478</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046039.1">
        <property type="nucleotide sequence ID" value="XM_003045993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7M5"/>
    <dbReference type="GeneID" id="9669023"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76478"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76478"/>
    <dbReference type="eggNOG" id="ENOG502T50E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031302_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z7M5"/>
    <dbReference type="OMA" id="EHMLNFG"/>
    <dbReference type="OrthoDB" id="4314040at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="57"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU40326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="614" mass="68796" checksum="E3F2A5F5A2E92852" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7V5</accession>
    <name>C7Z7V5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">OPT family small oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_93043</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045470.1">
        <property type="nucleotide sequence ID" value="XM_003045424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7V5"/>
    <dbReference type="FunCoup" id="C7Z7V5">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="GeneID" id="9672632"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_93043"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_93043"/>
    <dbReference type="eggNOG" id="KOG2262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004965_1_1_1"/>
    <dbReference type="InParanoid" id="C7Z7V5"/>
    <dbReference type="OMA" id="AYHEYSV"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="518"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="548"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="600"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="669"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="716"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="747"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU39757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="822" mass="93597" checksum="82EDC8955A4CB4D1" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8H1</accession>
    <name>C7Z8H1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_94251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045047.1">
        <property type="nucleotide sequence ID" value="XM_003045001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8H1"/>
    <dbReference type="GeneID" id="9673032"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94251"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94251"/>
    <dbReference type="eggNOG" id="ENOG502S2W1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040908_3_2_1"/>
    <dbReference type="InParanoid" id="C7Z8H1"/>
    <dbReference type="OMA" id="WYDNFAG"/>
    <dbReference type="OrthoDB" id="43654at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000207">
        <property type="entry name" value="Glycoside hydrolase family 128 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF3">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002987946" description="Asl1-like glycosyl hydrolase catalytic domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="2">
        <location>
            <begin position="25"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU39334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="316" mass="34747" checksum="F02ABA876E7A9694" modified="2009-10-13" version="1">MTSKRTLLATLLAGFASATPNGKRGLVYTADRNEAKDDKIWIQNGSDITWYYNYADYPSPVYEDIPQEQFEFVPMMWGVGSDSSDTSFLESVQARIKSGTNITHVLGFNEPDASNDVGGSNLDPKTAAEAWVANFEPLGQMGIKLGLPACTGGWSSMPWLKQFLGNCTQIKNKAGTKGNCTWDYLPVHWYDNFEGLASHIGEHLAEWPDAEIWVTEYAYAHQDPGPTDAFFRQTLKWFDESDFIGRYTYFGAFRSGISNVGPNAALLTNDGDLTDIGAEYLGLNTTGEDSAAPSAVNLPHIGFMALVMAMVLKMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8W7</accession>
    <name>C7Z8W7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Short-chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_81654</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044758.1">
        <property type="nucleotide sequence ID" value="XM_003044712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8W7"/>
    <dbReference type="STRING" id="660122.C7Z8W7"/>
    <dbReference type="GeneID" id="9673668"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_81654"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_81654"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="InParanoid" id="C7Z8W7"/>
    <dbReference type="OMA" id="FAQQESK"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF236">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU39045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="35081" checksum="EA5C534B3409E87E" modified="2009-10-13" version="1">MTFRALYTQLFPPAPPLTEDNVPSQRGKVFIVTGGNSGVGFELCKILYTTGATIYMTSRSEERAMNAIKQIKSSEPANPGVLNFLHLDLDDLHSVRVSAAKFASQEAKLDVLWNNAGTGGYRVSPGAKTAQGLEAMVGMHCVATLLFTTLLLPQLRAAVSARVVWTSSIVADQGSPPNGINFDTLSTGTPDRVLNYAVSKVGSWMLSRELARRHGSEGIISVAQNPGNVKGGSYEGTPAATMFLLNRFLLHPSKFGAYTELYAGLSPDITPGDNGAYIIPWGRIRPDAECPRRDIVHAMLREEDGGLGYCSKLWDWCEEQWQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8Z3</accession>
    <name>C7Z8Z3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_43049</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045021.1">
        <property type="nucleotide sequence ID" value="XM_003044975.1"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z8Z3"/>
    <dbReference type="GeneID" id="9673486"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_43049"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_43049"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003997_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z8Z3"/>
    <dbReference type="OMA" id="HTRWWLT"/>
    <dbReference type="OrthoDB" id="3633556at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF10">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="917"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1108"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1152"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1396"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1448"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="770"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1349"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1356"/>
            <end position="1372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU39308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1650" mass="180698" checksum="4E710D7758B70FD5" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9E2</accession>
    <name>C7Z9E2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase M13 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_43284</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044793.1">
        <property type="nucleotide sequence ID" value="XM_003044747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9E2"/>
    <dbReference type="STRING" id="660122.C7Z9E2"/>
    <dbReference type="GeneID" id="9673778"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_43284"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_43284"/>
    <dbReference type="eggNOG" id="KOG3624">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006187_4_3_1"/>
    <dbReference type="InParanoid" id="C7Z9E2"/>
    <dbReference type="OMA" id="DQRFFMN"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="9">
        <location>
            <begin position="36"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="8">
        <location>
            <begin position="518"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU39080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="723" mass="80460" checksum="BAE09F20A081CCB4" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9F0</accession>
    <name>C7Z9F0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_81730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045209.1">
        <property type="nucleotide sequence ID" value="XM_003045163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9F0"/>
    <dbReference type="GeneID" id="9673781"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_81730"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_81730"/>
    <dbReference type="eggNOG" id="ENOG502QQ7D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003000_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z9F0"/>
    <dbReference type="OMA" id="MAQSMNG"/>
    <dbReference type="OrthoDB" id="5332281at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="510"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="575"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1103" mass="120653" checksum="C412837D71F4E696" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9R2</accession>
    <name>C7Z9R2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_94537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045259.1">
        <property type="nucleotide sequence ID" value="XM_003045213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9R2"/>
    <dbReference type="STRING" id="660122.C7Z9R2"/>
    <dbReference type="GeneID" id="9672214"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94537"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94537"/>
    <dbReference type="eggNOG" id="ENOG502SHG8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_138_0_1"/>
    <dbReference type="InParanoid" id="C7Z9R2"/>
    <dbReference type="OMA" id="FARSKWH"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF12">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="22"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU39546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="274" mass="31735" checksum="E7E97DF9274C8BD3" modified="2009-10-13" version="1">MWLINTETMRLESVVNPETVEYAILSHTWEEEEVSFQEFQDLEFARTRKGFAKIEMTCLFAKSQGYPYAWVDTCCIDKSSSAELSEAINSMFRWYKDAQYCYAYLSDYHPTTVDESFGRCRWFTRGWTLQELIAPTFITFYNRDWESLGSKIELHQVISKITRINSDVLLGECDVSTIDVVYRMSWAAGRETTRAEDIAYCLFGIFDVNLPMLYGEGSKAFLRLQEEICQRVADLTLFAWKTEVDEGDGDKIRGIFALSPNEFACARVEPGRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9T0</accession>
    <name>C7Z9T0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_43837</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044866.1">
        <property type="nucleotide sequence ID" value="XM_003044820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9T0"/>
    <dbReference type="FunCoup" id="C7Z9T0">
        <property type="interactions" value="292"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z9T0"/>
    <dbReference type="GeneID" id="9672224"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_43837"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_43837"/>
    <dbReference type="eggNOG" id="KOG1119">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069054_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z9T0"/>
    <dbReference type="OMA" id="QFKITDN"/>
    <dbReference type="OrthoDB" id="1938621at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011:SF1">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="2">
        <location>
            <begin position="110"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU39153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="244" mass="26894" checksum="443D223F949EA9EC" modified="2009-10-13" version="1">MASLHCANAPSAARSFIQLARRSYSTAAASQSSTPLEFLVPRCAPSPLRVTEVSTTASRVHVHTRNSNNSRWLWRSNLHARAVRAFSTSAARHQTRAILNPQEDEDGKEMMLEITERAAKKRLNKIMEKDGNPNLALRIQVESGGCHGFQYLMSLITLPPKDTPEWSNIVNEDDTIFQYIPEDADPATASEDGPKVVLDEPSLDLLKGSKVDFTTELIGSQFKIVDNPFATSSCGCGTSFDIKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZA94</accession>
    <name>C7ZA94_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_43741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the esterase D family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044949.1">
        <property type="nucleotide sequence ID" value="XM_003044903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZA94"/>
    <dbReference type="ESTHER" id="nech7-c7za94">
        <property type="family name" value="A85-IroE-IroD-Fes-Yiel"/>
    </dbReference>
    <dbReference type="GeneID" id="9672131"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_43741"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_43741"/>
    <dbReference type="eggNOG" id="ENOG502S92V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039834_3_0_1"/>
    <dbReference type="InParanoid" id="C7ZA94"/>
    <dbReference type="OMA" id="RRMTDNC"/>
    <dbReference type="OrthoDB" id="446683at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052558">
        <property type="entry name" value="Siderophore_Hydrolase_D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40841">
        <property type="entry name" value="SIDEROPHORE TRIACETYLFUSARININE C ESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40841:SF2">
        <property type="entry name" value="SIDEROPHORE-DEGRADING ESTERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU39236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="310" mass="34731" checksum="263AD96D21E351C5" modified="2009-10-13" version="1">MTQLPLAFEHANAYNSCQFLFPTRRGDYLVQVSWPLCWSEKRIPPEHDAGKSVSTIYVVDGNAYFFTATDIVRRLEFTNHTRTIIVAIGYPNKTCVFDKRRTGDLTIPSSAATYDIPPGPDGKPNLGPFGGADDFLDVIRSDIAPYVDETLFPDAPVNSGPRALFGHSYGGLFTLNALFTKPEAFDTFIAASPSIWFNHECLVREQEARFHEREPPTGKAPRLLVMFGGAEQTLIRQPGDSDETFKRKQKWAAARRMKDNALELAARMEESPNVCGVWRWEFEGEDHGGAAPCALQRGLVRFLLDQKLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAE0</accession>
    <name>C7ZAE0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_70557</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045373.1">
        <property type="nucleotide sequence ID" value="XM_003045327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAE0"/>
    <dbReference type="STRING" id="660122.C7ZAE0"/>
    <dbReference type="GeneID" id="9672154"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_70557"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_70557"/>
    <dbReference type="eggNOG" id="ENOG502SJ6K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019101_2_2_1"/>
    <dbReference type="InParanoid" id="C7ZAE0"/>
    <dbReference type="OMA" id="NEWTIWY"/>
    <dbReference type="OrthoDB" id="3903189at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF149">
        <property type="entry name" value="UBID FAMILY DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="22"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="335"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU39660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="390" mass="44387" checksum="25898CA98C3E1E4C" modified="2009-10-13" version="1">MSAFVTEIWTWYALTWVIVICRMISRRMLLGSIKKLQVEDYLMLFAMITDTVLMVGMSIVSRTSSNLIDPNDKHVLSQAEIDERIRGSKWVLVVEQMQIITIWTMKYCLLLMYNRLTMSLRQNIAVKFVAGYVTLGLVLMEILYLGVWCRPFNQFWAVPPKNTQCATQTNHLIVNTVLNISSDVMIILIPMPIFLKSQLPLKRKIVLIGVFALGAFTILSAILSKFYSFNEPFGSNWTFWYVRESSTALLTSNLPYIWTLLRRLFNLGSFNGSSYGKRSTNPSTAFRSNFTNHRSGVRSQVRAEGGTLHRLDSEEQINATYSMPLKIYQKHEVEISSEEAGPEDRRSPPGVVPRDLEGHKDLSTRSSSRDDMETGSERSAVGVVKVFHGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZB86</accession>
    <name>C7ZB86_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7702 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_83009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044363.1">
        <property type="nucleotide sequence ID" value="XM_003044317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZB86"/>
    <dbReference type="GeneID" id="9672866"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83009"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83009"/>
    <dbReference type="eggNOG" id="ENOG502SUUA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064985_1_1_1"/>
    <dbReference type="InParanoid" id="C7ZB86"/>
    <dbReference type="OMA" id="WHFRIPE"/>
    <dbReference type="OrthoDB" id="2560628at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056119">
        <property type="entry name" value="DUF7702"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24800">
        <property type="entry name" value="DUF7702"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="2">
        <location>
            <begin position="6"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="2">
        <location>
            <begin position="76"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU38650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="240" mass="26953" checksum="CF2F7E35972D301E" modified="2009-10-13" version="1">MTGEFKFRHGISATQIPIFSVFLFFGTLFYFQKKNGWFSIALFSIIRLTGASCMLATLANGSYGVWAAVYRANTFAQVLTPWHFRVPELICWAGMGLSIADYATASQREDAAKPGSLAQASMGLFVALYAWALLLGFYLIQRWSSIPEEERWGMWSFGACVPFMIVRTTYSVAFTATGDKKFSAVVGRPYMYLFMSLVMETTILGIVTWAIYTMSRLVATAPKDSVEGGSYRMMDMRDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBY8</accession>
    <name>C7ZBY8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_98155</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698916">
        <property type="protein sequence ID" value="EEU38447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044160.1">
        <property type="nucleotide sequence ID" value="XM_003044114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBY8"/>
    <dbReference type="STRING" id="660122.C7ZBY8"/>
    <dbReference type="GeneID" id="9670551"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_98155"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98155"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_3_1"/>
    <dbReference type="InParanoid" id="C7ZBY8"/>
    <dbReference type="OMA" id="FYWIDPA"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF238">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01680)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988990" description="FAD-binding domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="5"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU38447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="418" mass="46722" checksum="8539D599FF0FC936" modified="2009-10-13" version="1">MPLSIVVIGAGLGGLAAALSVKQESPDHDVLIVESAPVLAEIGAGLQLTPNATRLLLRWGLKPFLEELASSPEEFLVRRFDGRKLLGERQNFAAEMLDKYQSHYWDMHRADLQFAMFERAKSLGVRFQFGTLVTDVDLAIPQLTTDKGGKITGDLVIAADGLWSKTRSKVLGRPSHPIATGDLAYRIVLKSEDIQDQELLDFMNKPRVCLWVGPECHAIYYPLRNNTMANIVLLVPDNLPDNVAKMPGDLCEMREIFDKWDPLLQKFLSQVNKIEKWKLMHLDELERWYNEEATVVFLGDACHPMLPYMAQGAGSALEDGAALGILFSKVRNREQLPDALKTYQDLRSAILGKGGVKREDGPEQEARDKLAESQLYDQQPGYPFYWIDPGAQDFVYGYDVIAELKKIGVEPATHNPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCW5</accession>
    <name>C7ZCW5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_84362</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698919">
        <property type="protein sequence ID" value="EEU38116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043829.1">
        <property type="nucleotide sequence ID" value="XM_003043783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCW5"/>
    <dbReference type="GeneID" id="9669915"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84362"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84362"/>
    <dbReference type="eggNOG" id="ENOG502SWK2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079951_1_1_1"/>
    <dbReference type="InParanoid" id="C7ZCW5"/>
    <dbReference type="OMA" id="YWGRFYR"/>
    <dbReference type="OrthoDB" id="4074965at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G08640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G08640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="14"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU38116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="216" mass="24576" checksum="83C86B6D45FC96C1" modified="2009-10-13" version="1">MPEEKTGTTHKVCSVILRLGQIACATIVIGILARFSYVLTIAQVHEDGRLVYAMVVAGMSIVYSFLLCPPFRNLFLSFPCDFILFIMWLVAYCLLQTKSGTNTCSSTWYRTYWGYYWGRYWRVGRPGVVNVGRAGCGQWRTVLAFSFIAWFAYLLSGILGIYVFHRYIKVKETTAEFKHQAKKHLGRDSQENDYGRPVNEPRGAGVEQPVTQVSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDN0</accession>
    <name>C7ZDN0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_88108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043450.1">
        <property type="nucleotide sequence ID" value="XM_003043404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZDN0"/>
    <dbReference type="GeneID" id="9669760"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88108"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88108"/>
    <dbReference type="eggNOG" id="ENOG502SSG5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_415653_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZDN0"/>
    <dbReference type="OrthoDB" id="4834801at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="660" mass="72061" checksum="0342508FABEDB40A" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDN5</accession>
    <name>C7ZDN5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_102200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043570.1">
        <property type="nucleotide sequence ID" value="XM_003043524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZDN5"/>
    <dbReference type="STRING" id="660122.C7ZDN5"/>
    <dbReference type="GeneID" id="9669763"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102200"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102200"/>
    <dbReference type="eggNOG" id="ENOG502R8ID">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_657389_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZDN5"/>
    <dbReference type="OMA" id="IRNRRTW"/>
    <dbReference type="OrthoDB" id="3525185at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU37857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="431" mass="47760" checksum="0E005B7173E547BD" modified="2009-10-13" version="1">MPRRSRGCAACRRRRIGCDGELPVCRQCRITNRQCSGPLQGALVIDQTDRIIFKNRPKPEMIHQPSNQSMFAHAFINEFISFITARSEQARRQSWLTELQSGSMAEQGPALELSMQATALAYCGTVSGNPAAVREACNIYGRALTKHSRSLTHDLSSPKAASLGTCVMLSFFEAICSTNPIAYGTHLQAAKKMLALMPCVAGHKDELVIWQLGQHVQSQSLFVMLSTPDQYLQHAPVPACWTKMAENEEHPATSQQGVDRLMYDLFFLTDVLVRRSYTTETEILLNADIIPELDQLWLEFKEQATQLGELIQWPVPSGAQYHDPFIAMVVAYFGASWVLLSILGPQISNRQLGESCDAILESSRFLGGKNLGCAHLRMFFPLTLVAMHGPCSAQREAADRLLGQRIQSTAFKGMGSVAIGRVQSSRVLYHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZE50</accession>
    <name>C7ZE50_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_87444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698921">
        <property type="protein sequence ID" value="EEU37672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043385.1">
        <property type="nucleotide sequence ID" value="XM_003043339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZE50"/>
    <dbReference type="STRING" id="660122.C7ZE50"/>
    <dbReference type="GeneID" id="9669270"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87444"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87444"/>
    <dbReference type="HOGENOM" id="CLU_1845621_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZE50"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU37672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="139" mass="15821" checksum="7D7DF89FC0D1E91F" modified="2009-10-13" version="1">MGFPLFPGSKKGGLWHRAVLNDTSIWEQVLVDVLAGETLSVNIVPLGSGEHPIPRDQRLTTVKYLLNHGFYMSEVQIWNGVRGLKDELENTPSTDPEYEYYGAVVACLDDMTQLIQRKTRFTWALERLRSGVGFLIRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZET3</accession>
    <name>C7ZET3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_51460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043058.1">
        <property type="nucleotide sequence ID" value="XM_003043012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZET3"/>
    <dbReference type="GeneID" id="9665250"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51460"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51460"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZET3"/>
    <dbReference type="OMA" id="TWHAWQK"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF5">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_6G09140)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU37345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="231" mass="24786" checksum="EB2678F6997B4FCB" modified="2009-10-13" version="1">MSGRLQGKTAIVTGGASGFGKGIAAKFVSEGANVIITDLSSEAGEAVASELKCHFLRADVTKPDDWRAVLSLALERFKQLDIVINNAGATYPNKPTEDATEADFDLVMNVNVKSVYHSTNILLPYFLKEKRPGCFIQVASTAGSRPRPKLTWYNASKAAVINATKTMALDRTHLFIGKPDTEENRKGFVSTIPLGRPSTPGDIANACCYLASEEANFITGVDLEVDGGRCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEU9</accession>
    <name>C7ZEU9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_51519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043150.1">
        <property type="nucleotide sequence ID" value="XM_003043104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEU9"/>
    <dbReference type="FunCoup" id="C7ZEU9">
        <property type="interactions" value="256"/>
    </dbReference>
    <dbReference type="GeneID" id="9665255"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51519"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51519"/>
    <dbReference type="eggNOG" id="ENOG502QRXN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033165_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZEU9"/>
    <dbReference type="OMA" id="CNRWGGD"/>
    <dbReference type="OrthoDB" id="2014654at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000191">
        <property type="entry name" value="Retrograde regulation protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050273">
        <property type="entry name" value="GppA/Ppx_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057512">
        <property type="entry name" value="RTG2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30005">
        <property type="entry name" value="EXOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30005:SF0">
        <property type="entry name" value="RETROGRADE REGULATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23566">
        <property type="entry name" value="RTG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx/GppA phosphatase N-terminal" evidence="1">
        <location>
            <begin position="68"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="RTG2 C-terminal" evidence="2">
        <location>
            <begin position="384"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU37437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="612" mass="67693" checksum="3D182077FDAD3657" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEX3</accession>
    <name>C7ZEX3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_86329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043183.1">
        <property type="nucleotide sequence ID" value="XM_003043137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEX3"/>
    <dbReference type="GeneID" id="9665200"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86329"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86329"/>
    <dbReference type="HOGENOM" id="CLU_549918_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZEX3"/>
    <dbReference type="OMA" id="VNCINAT"/>
    <dbReference type="OrthoDB" id="4818194at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="496" mass="55776" checksum="1E82FFAFED7A6948" modified="2009-10-13" version="1">MGCVQSKEAGHNQVGNRPVMLTTLPQANAILHRHPPYPTVQDTQGYQQPAVNQPNFKLTQVVEEAELPDYHPEASVDYILRTILDAENFSKHGIKGAFNVLGDRHFNIFIDSSHSLSSETRCAILLVATVLLIVAQAKDCDMTFYFTSYPNKKSKNLSEIDRRHLKDLINLWKTQSWQEALGMVQYTKPFQGKLGIQDWINKRKNITDDQSDVEKHAKLLNYCREKMLAFWHGWHQRELTVDSLEKLYGSAMVNASQQLNSLNSTAFTYKRAMGQYTRLQQLYQKDPSQAFPVSNIFLLGTAIQPTELAAIQEAQNIGGNTGSSRGRLGSLNIEGRGTLFQISSVVMIDRMTEKSIKLYKKVDNYGKGEDDINDLNTLKERKVLTNFLSPGAFFKILNSHEPAVDNDIQMPTGDAMYGRQLLNANGHTITLPGVNQVKRIFGIEDLSALPRAMDDSEDEDDKPARPRTGRARFEVSTDAAERSSDKFFTPPTSSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZF80</accession>
    <name>C7ZF80_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">G protein-coupled receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_78373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698923">
        <property type="protein sequence ID" value="EEU37175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042888.1">
        <property type="nucleotide sequence ID" value="XM_003042842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZF80"/>
    <dbReference type="GeneID" id="9665030"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78373"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78373"/>
    <dbReference type="HOGENOM" id="CLU_885930_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZF80"/>
    <dbReference type="OrthoDB" id="10354289at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002989069" description="G protein-coupled receptor" evidence="2">
        <location>
            <begin position="20"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU37175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="34951" checksum="9A609136D4B569E8" modified="2009-10-13" version="1">MTLLLVIKLILQCTHKARQYHGYGTTLYRHLQVATGLLAMFCFLDMVEYATLLPQIKPAAADSLVVNRFQLYIAGPAKAFYCLADGPIFIILVRVGLSLGGSQNQHGTPYRKSARILSLAVPFMLLVPVLTHIGYVCDFVSSMGRPYNDVSPGHLLFTAIRVDIACSVLVLSLSCIVLIHTASMAFTLHGFSANKFSSGQTLYIRCSVLWVLQAIFYTTFTCICYAYYGIKPLSSNDECLMEIELMDSEEIPLCVLSQLPGSYFYFFSVILVAGSKYLILRLLLKRSDVDELVEFFVDEDVELDTVSIASSEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFI9</accession>
    <name>C7ZFI9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_99822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698923">
        <property type="protein sequence ID" value="EEU37160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042873.1">
        <property type="nucleotide sequence ID" value="XM_003042827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFI9"/>
    <dbReference type="STRING" id="660122.C7ZFI9"/>
    <dbReference type="GeneID" id="9665152"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_99822"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_99822"/>
    <dbReference type="eggNOG" id="ENOG502S8TM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002639_2_12_1"/>
    <dbReference type="InParanoid" id="C7ZFI9"/>
    <dbReference type="OMA" id="NITINWQ"/>
    <dbReference type="OrthoDB" id="5362512at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="300"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="843" mass="95109" checksum="2F6FA6DE77CEFDF6" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFK0</accession>
    <name>C7ZFK0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_37208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698923">
        <property type="protein sequence ID" value="EEU37166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042879.1">
        <property type="nucleotide sequence ID" value="XM_003042833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFK0"/>
    <dbReference type="STRING" id="660122.C7ZFK0"/>
    <dbReference type="GeneID" id="9665015"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_37208"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_37208"/>
    <dbReference type="eggNOG" id="KOG1541">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090201_3_1_1"/>
    <dbReference type="InParanoid" id="C7ZFK0"/>
    <dbReference type="OMA" id="WESGGFK"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF110">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="62"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU37166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="207" mass="22476" checksum="DB80FBA64683000D" modified="2009-10-13" version="1">MSGIQRVLNLSGNAEAQAAYDDWAENYDNDMLGESEDYVAPEIASDYVKRYLGSRPIEHVKILDAGCGTGLVGASLAKKGAKHIDGIDLSPGMLQVAERSGAYETLSVANLSQRLDIPDQTYDVVVCVGTMTQGHVGPEAFDEFARIIKPGGFIISTVRDTFWKMNGYEDKVKSLDKAGKLKLLSVELEDYRRGAGVQAVMVVLQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFM7</accession>
    <name>C7ZFM7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_78421</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698923">
        <property type="protein sequence ID" value="EEU37197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042910.1">
        <property type="nucleotide sequence ID" value="XM_003042864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFM7"/>
    <dbReference type="STRING" id="660122.C7ZFM7"/>
    <dbReference type="GeneID" id="9665055"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78421"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78421"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="InParanoid" id="C7ZFM7"/>
    <dbReference type="OMA" id="WINLWTI"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF172">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU37197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="59638" checksum="E42359FDA30D60E0" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFX2</accession>
    <name>C7ZFX2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_86755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698924">
        <property type="protein sequence ID" value="EEU37133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042846.1">
        <property type="nucleotide sequence ID" value="XM_003042800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFX2"/>
    <dbReference type="STRING" id="660122.C7ZFX2"/>
    <dbReference type="GeneID" id="9664962"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86755"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86755"/>
    <dbReference type="eggNOG" id="ENOG502SQ5Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_377713_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZFX2"/>
    <dbReference type="OMA" id="WILAQSS"/>
    <dbReference type="OrthoDB" id="4838614at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="621"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="709"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="734" mass="84619" checksum="EBC55308D94E9684" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZG10</accession>
    <name>C7ZG10_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cyclin-dependent kinase 1</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">NECHADRAFT_86624</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Plays a key role in the control of the eukaryotic cell cycle. Required for entry into S-phase and mitosis. Acts as a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II. May function in concert with npp-16 to arrest prophase blastomeres in response to anoxia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Interacts with cks-1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="GG698924">
        <property type="protein sequence ID" value="EEU36976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042689.1">
        <property type="nucleotide sequence ID" value="XM_003042643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZG10"/>
    <dbReference type="FunCoup" id="C7ZG10">
        <property type="interactions" value="911"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZG10"/>
    <dbReference type="GeneID" id="9664804"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86624"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86624"/>
    <dbReference type="eggNOG" id="KOG0594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_6_1"/>
    <dbReference type="InParanoid" id="C7ZG10"/>
    <dbReference type="OMA" id="PDETKWP"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07835">
        <property type="entry name" value="STKc_CDK1_CdkB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000706">
        <property type="entry name" value="Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000027">
        <property type="entry name" value="Putative Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF254">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="4"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEU36976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="319" mass="36367" checksum="13FBEEFBB3FE5B6E" modified="2009-10-13" version="1">MDNYQRIEKVGEGTYGVVYKARDLAHNGRLVALKKIRLETEDEGVPSTAIREISVLREMNHPNVVSLLNIVHADSHKLYLVLEFLDLDLKKYMDSLPVSDGGRGKPLPSGSSATIRTLGMGDQVVRKFMLHLCEGIKYCHSHRVLHRDLKPQNLLIDKEGNLKLTDFGLARAIGVPLRTYTHEVVTLWYRAPEVLLGGRQYSTGVDMWSIGCIFAEMCTRKPIFAGDSEIDEIFKIFRILGTPDNEIWPDVTSYPDFKPSFPKWRRNYDAPLCPNLDEEGLNLLDLLLVYDPAYRLSAKRACTHPYFDKILYENEKIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZGG2</accession>
    <name>C7ZGG2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_12335</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698925">
        <property type="protein sequence ID" value="EEU36844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042557.1">
        <property type="nucleotide sequence ID" value="XM_003042511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZGG2"/>
    <dbReference type="STRING" id="660122.C7ZGG2"/>
    <dbReference type="GeneID" id="9670142"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_12335"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_12335"/>
    <dbReference type="eggNOG" id="ENOG502SHT0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012331_2_0_1"/>
    <dbReference type="InParanoid" id="C7ZGG2"/>
    <dbReference type="OMA" id="FYCVWTP"/>
    <dbReference type="OrthoDB" id="189997at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14653">
        <property type="entry name" value="ZIP_Gal4p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="11"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="67"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU36844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="569" mass="64139" checksum="C4DC1F23709BC10C" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZGJ9</accession>
    <name>C7ZGJ9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_42326</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C56 family. HSP31-like subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="GG698925">
        <property type="protein sequence ID" value="EEU36905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042618.1">
        <property type="nucleotide sequence ID" value="XM_003042572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZGJ9"/>
    <dbReference type="STRING" id="660122.C7ZGJ9"/>
    <dbReference type="GeneID" id="9670118"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_42326"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_42326"/>
    <dbReference type="eggNOG" id="ENOG502RZ3Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070319_2_0_1"/>
    <dbReference type="InParanoid" id="C7ZGJ9"/>
    <dbReference type="OMA" id="NFFANDP"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03141">
        <property type="entry name" value="GATase1_Hsp31_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF11">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="6">
        <location>
            <begin position="95"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU36905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="234" mass="25553" checksum="B4E02A1E4241314D" modified="2009-10-13" version="1">MSPKPKLLIILTSQDILPTRDNMKTGWYLPELVHPYNMLVPHVDVVIASPKGGEAPIDPYSVEETKDDAACQAFLRDNEPLWKNTTKLESFLGRSSEFAGIFFVGGHGPMFDLAVDSISQELIREFYEAGKIVSAVCHGPAALVNVKLSDGTYMVQGHAITGFSNAEEDAYQFTDAMPFLLEDELKKHGGNYEKADQPFGIRVVVSGNLVTGQNPPSAGVIGGSLVEEIQRREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHA9</accession>
    <name>C7ZHA9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_105607</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698927">
        <property type="protein sequence ID" value="EEU36719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042432.1">
        <property type="nucleotide sequence ID" value="XM_003042386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHA9"/>
    <dbReference type="GeneID" id="9669513"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_105607"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_105607"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="InParanoid" id="C7ZHA9"/>
    <dbReference type="OMA" id="CSTANGY"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF13">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="477"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="47"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU36719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="546" mass="59712" checksum="C6261AFC020EC41A" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHB4</accession>
    <name>C7ZHB4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Choline transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_51757</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698927">
        <property type="protein sequence ID" value="EEU36635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042348.1">
        <property type="nucleotide sequence ID" value="XM_003042302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHB4"/>
    <dbReference type="GeneID" id="9669676"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51757"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51757"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_2_4_1"/>
    <dbReference type="InParanoid" id="C7ZHB4"/>
    <dbReference type="OMA" id="GPFWYPK"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF7">
        <property type="entry name" value="CHOLINE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU36635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="492" mass="53021" checksum="9150641019A9B19B" modified="2009-10-13" version="1">MTEKVDTEAPERASVTYGEVTVQTVKPFTTLSALGIGYGTTNTAVGLLLVLGSTLPMGGSPLFFWGFLVMAIVGLATATTLAELASAMPHPGGQYIWVNRLAPSHSRRVLSYITAVISWLAAVATGASACLSVPTGACAIISLLDPNFVYKRWMGFVGFQLLNIITVFCASFEHALPKISKIMLLFSCVTITVIFITLFAMSDEHASAKDYFTTSVNVSGWPKGVAFIIGMNGANWSFSCLDVATHLAEEMPSPSTDIPKALIWTIVVGFTSGLLVVTSILINVTSIDGAADNSAVALFYRITGSKAAAVGLWIPVLITTAGAVWSIQTWQSRLAWTISREAGFPLHRHLSKLAPAPLQTPVWSLLWSASGTAIFGCLYLGSELAFNSLISTGLLLQYISYSIPVVLMLLQGRSNFQHGPFWYPRLGLLANVVMLAWALVALIFYCFPYYLPVMADGMNYTSAVLGGIAIVTGTLWFVYANKNYEVKEILDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHC1</accession>
    <name>C7ZHC1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase family 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_106463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698927">
        <property type="protein sequence ID" value="EEU36656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042369.1">
        <property type="nucleotide sequence ID" value="XM_003042323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHC1"/>
    <dbReference type="STRING" id="660122.C7ZHC1"/>
    <dbReference type="GeneID" id="9669535"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_106463"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_106463"/>
    <dbReference type="eggNOG" id="ENOG502S2TH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034860_3_0_1"/>
    <dbReference type="InParanoid" id="C7ZHC1"/>
    <dbReference type="OMA" id="YEEYWAQ"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU36656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="40016" checksum="150F8B7DFACCF662" modified="2009-10-13" version="1">MNSCLRCSGQSSVFKFFCVFVLVTLILVLTGQYESVLEPPRVPQPTISVVSDQENAYVFYATDNTYACSVLVNVHILRKTHETKRRIIVLVSKDVSSKYHSSFKSLSAEVIQRKPMGLHPEANKDYKSSLLKLEAFGLPEIDPCLKRLLVVEGDQLVLKDLDHLFDLPPADIYAPKAYWARDELFSSTLMLIQPKPEIWNDIKEMVPNLQPNQLEMDVINDIFSGKAAPIPESYVVLNSHWSEWTLPSWFTPSASVTTSEVAGATPTPSAKPSNEELDELSLQAHIIHFSAEIGKPWDYDVWQVGELEFNAHQVLLLQWQEWRLLQKLGFVRPCVKEPGRVLIDLLRVTRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHE8</accession>
    <name>C7ZHE8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_42631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698928">
        <property type="protein sequence ID" value="EEU36422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042135.1">
        <property type="nucleotide sequence ID" value="XM_003042089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHE8"/>
    <dbReference type="STRING" id="660122.C7ZHE8"/>
    <dbReference type="GeneID" id="9669098"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_42631"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_42631"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_6_1_1"/>
    <dbReference type="InParanoid" id="C7ZHE8"/>
    <dbReference type="OMA" id="VCYPAGY"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="89"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU36422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="322" mass="34770" checksum="B9F4DC9AB41EAE7C" modified="2009-10-13" version="1">MAAALSYDPEYLAAVSVLPPTERPDTFADVFELRNFTEDALFNIIHMLPTPAGITETKFQYKSLDNTTVSLYRFTSKEITDATKPGPAVVFAHGGGGISCSVEVYAPQIARYVADTGITFFAVDYRLAPEDPAPAAVDDVFAGLKYISSHASELNIDPKRIAVMGDSAGGGLAAGAALMARDKGLSPPLAKQILVYPMLDDRTKLPKGSPLEPFLIWKTGDNKQAWAAILGDEAGKEDTNVSIYAAPGRAKDLRDLPSTYVEVGGLDLFRAEDLSYASRIAAEDIEVELHLWPGLPHVYEVASEATIVKKALDARMRALKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHI4</accession>
    <name>C7ZHI4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_102695</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698928">
        <property type="protein sequence ID" value="EEU36474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042187.1">
        <property type="nucleotide sequence ID" value="XM_003042141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHI4"/>
    <dbReference type="FunCoup" id="C7ZHI4">
        <property type="interactions" value="222"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZHI4"/>
    <dbReference type="GeneID" id="9669218"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102695"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102695"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_172_2_1"/>
    <dbReference type="InParanoid" id="C7ZHI4"/>
    <dbReference type="OMA" id="YVQQVPM"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13993">
        <property type="entry name" value="STKc_Pat1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000549">
        <property type="entry name" value="Protein serine/threonine kinase (Ran1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF68">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATG1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="54"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="354"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU36474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="506" mass="57024" checksum="4217DBFB42A78195" modified="2009-10-13" version="1">MQHHAIFGYQTPPASPGFDNPKCTIQQPFAVPRHYPTRPLAPEERLGRVLEGTLQLTEILGTGAYGVVYLAVDLKTGGKYAVKCLSKFNADGTQLEPRQFAYQQREIRLHWKASNHANVVQMLKIVNDPDCIYVILEYCPEGDLFLNITERGQYVGKDELSRNIFLQILDAVEHCHNLGIYHRDLKPENILVTDRGDTVKLADFGLATSDDRSEDYGCGSTFYMSPECLDPSARKPYYMCAPNDVWSLGVILVNLTCGRNPWKQASFQDSTYRAYAGSKDFLKTILPLSDELNEILGRIFEPNPEQRITLNELRTRIMACSRFTMPAVSPPTPPASPDHTTQYVSTEDAIIDDYDYDSPLSPASSSDDEGSLTSSGSTIDDLDDDFDQERQMPQTPPEYAPHAFDPEEPKEHQLIYHSQEFVPQKYSGPVPVPVQVPVGVPPQPMLCQPVPVPIQAPVPIQAPCQQHKSYFPIWDMVKYVQHVPILQHHIPFHQQVPFMPTFQGCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHK4</accession>
    <name>C7ZHK4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_94095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698928">
        <property type="protein sequence ID" value="EEU36510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042223.1">
        <property type="nucleotide sequence ID" value="XM_003042177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHK4"/>
    <dbReference type="STRING" id="660122.C7ZHK4"/>
    <dbReference type="GeneID" id="9669252"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94095"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94095"/>
    <dbReference type="eggNOG" id="ENOG502SRWI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_842144_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZHK4"/>
    <dbReference type="OMA" id="RFGRKWK"/>
    <dbReference type="OrthoDB" id="5279542at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU36510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="34243" checksum="B2E9AEE062401FC3" modified="2009-10-13" version="1">MAPESSTQTDDAIASSSTAAPTRPPPTQQAPNNAPTQTQTGFQLYPGSYGQVFTPYQQQPANNGQQQPVFMNQQQWTPPPLVETKYWMVSKMSLHGASMVCCVVGMGLAFSLIGQDEDDFMGLDVLGITSGPILVFALVCDIVEVLTRALRKFKSGIHPGVQIALSLIIWIMTSIVGGMQATYSAIFNDDYSECSPQSTRYGRYDDEYQSCKTQYGGIRPKIIAMTIFTCLVFIAHFILFVFACIDMSRRNRNRRAPVMVFAAPPYWGPAGQGFQQMPQGNGPPTPNQGQPIPMQNWALPQCGKWVCGCGVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHX4</accession>
    <name>C7ZHX4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">NECHADRAFT_86897</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the secreted LysM effector family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="GG698929">
        <property type="protein sequence ID" value="EEU36292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042005.1">
        <property type="nucleotide sequence ID" value="XM_003041959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHX4"/>
    <dbReference type="STRING" id="660122.C7ZHX4"/>
    <dbReference type="GeneID" id="9674405"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86897"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86897"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001482_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZHX4"/>
    <dbReference type="OMA" id="PASYHYL"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053214">
        <property type="entry name" value="LysM12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700:SF2">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700">
        <property type="entry name" value="V CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="10 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002989288" description="chitinase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="15">
        <location>
            <begin position="291"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="15">
        <location>
            <begin position="356"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="16">
        <location>
            <begin position="477"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEU36292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1201" mass="131066" checksum="5161474F4FDBA584" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZI46</accession>
    <name>C7ZI46_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_73935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EEU36380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_73935"/>
    <dbReference type="eggNOG" id="ENOG502SVIW">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114609_2_0_1"/>
    <dbReference type="InParanoid" id="C7ZI46"/>
    <dbReference type="OMA" id="ATEYCTA"/>
    <dbReference type="OrthoDB" id="5100247at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU36380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="131" mass="14902" checksum="B2001C4557A9C69F" modified="2009-10-13" version="1">MSQSDMDLREQCFLDISVHDVLYYDGVPAVEPWATMYIDGLREKRFGDAIWARYQIFGDVEDGIIDGRLTVLEAIEEDAVGYKKNAPEAFDEAVAFYKSHSNSSDGHPEVIEIIMQIDREDVSDRYFPEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZIG6</accession>
    <name>C7ZIG6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_87135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698930">
        <property type="protein sequence ID" value="EEU36199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041912.1">
        <property type="nucleotide sequence ID" value="XM_003041866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZIG6"/>
    <dbReference type="GeneID" id="9674326"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87135"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87135"/>
    <dbReference type="eggNOG" id="ENOG502RFRK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_733819_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZIG6"/>
    <dbReference type="OMA" id="TEANPHH"/>
    <dbReference type="OrthoDB" id="5241264at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU36199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="43863" checksum="7872A5681FAB88AF" modified="2009-10-13" version="1">MARQTLLHSPRSASPSQNLPKRSNRFAQVAIRTSSTREPTSRRLARSTTHPLSQFSHITSPVRTWPSATIPSLSSGDESDSSSSISDSDSDSEDEDRAEEYSLPEEHEWQRLRSELLQLAQIQLKEFSSRVQYDTSPRTRSRMSKWQLEPLCFEEYQDPSDTELVVLCRPPKMRRHFHHACPFYVSDPVKHKQCLLLYNQQPIEGLIDHLTRHHIKPLYCARCSETFDTPISRDRHILDDKCDLLDPKPMDGIDQYQISRLWKKDRWHFDEKKRWRRIWTTVFPSQPPRSPYLDQGLGLEVSMARDFWSLYGWRCVSDFLSDRGSIIYHDDDEEKALDALCDLVQEDLLADIIGGCSERTRGNIARRGCQYSMAYNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJ66</accession>
    <name>C7ZJ66_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_49662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698932">
        <property type="protein sequence ID" value="EEU36022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041735.1">
        <property type="nucleotide sequence ID" value="XM_003041689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJ66"/>
    <dbReference type="STRING" id="660122.C7ZJ66"/>
    <dbReference type="GeneID" id="9674014"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_49662"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_49662"/>
    <dbReference type="eggNOG" id="ENOG502SN1P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076396_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZJ66"/>
    <dbReference type="OMA" id="GTHAAMM"/>
    <dbReference type="OrthoDB" id="4159781at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU36022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="276" mass="31132" checksum="237AB65568D75900" modified="2009-10-13" version="1">MTPPNPQKPSPPQKEYAFVTPHQHGARSHAMREHWRQRRHKKDLAKRQREHRPQHVLLPTPSTSEAADSQPSTETTDTGPESTVLAGGGMFDPAMFETDMDSMMNGVPGQAMSGMNLALGSARLDPFDQFPVLLTTQHHKLLHHWLSTYATMMFDDVHSQAFNPMRDVWCPLDLSNAASFNAIMAHSAAHLARMQGLRQSKEALKFKAEAVRIVQVWMDDPQRALSDDVLAAVLRLLTYEVWQRLKIFHLGTDVLFYRDIGEPRRSGTSITMASQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJ77</accession>
    <name>C7ZJ77_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_49659</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698932">
        <property type="protein sequence ID" value="EEU36030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041743.1">
        <property type="nucleotide sequence ID" value="XM_003041697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJ77"/>
    <dbReference type="STRING" id="660122.C7ZJ77"/>
    <dbReference type="GeneID" id="9674084"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_49659"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_49659"/>
    <dbReference type="eggNOG" id="ENOG502RIXY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006173_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZJ77"/>
    <dbReference type="OMA" id="IRCDGRP"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF4">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="177"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="61"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="806"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="826"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU36030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1010" mass="111423" checksum="F95639CEF0C7B607" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJJ5</accession>
    <name>C7ZJJ5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_91597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698933">
        <property type="protein sequence ID" value="EEU35861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041574.1">
        <property type="nucleotide sequence ID" value="XM_003041528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJJ5"/>
    <dbReference type="GeneID" id="9673945"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_91597"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_91597"/>
    <dbReference type="eggNOG" id="ENOG502SQ7E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034859_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZJJ5"/>
    <dbReference type="OMA" id="PFRDRLH"/>
    <dbReference type="OrthoDB" id="5089392at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="49595" checksum="47E1F4A444D65D93" modified="2009-10-13" version="1">MEMMKESTDFVALPQDVDKSSLAGPKSLIAVKKGMRWTQCDSPRLRNNLLGAVGFLELANAGDFAANVWNDTPVPVYAVVLMAIGGFTALVFSVFAFIDSRRAWANISFLRSQRKLLEDEKARRTTDSRPTQEIDVLLEITIRELRIEIINRWAMDVMLGGGAVLIGTGTFMAIGGANRRVWLASNILSGYLGNAPIAAFGLISATWAVIVWKKMRHHRLAAEKALKGAAALPLIKRRCFNLQLFYVINGIATILGGVGSMLTAERWWGYVILIPVIMSSLFCNFWWRKRVGYDRPWIADPAPMNTNGLVHALESTAQIRRAFQNGPGTILPRIVGGLPSPAFPEVVEFMVKHDLFEKFCLYLINNMHVAHVLGLQKSNRVELGLSHILEIPDIHHPQLVGLAEEFLKDEGARHFQTRERFMIEILGTHLILTEEDREIEAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKM4</accession>
    <name>C7ZKM4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_64367</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698940">
        <property type="protein sequence ID" value="EEU35434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041147.1">
        <property type="nucleotide sequence ID" value="XM_003041101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKM4"/>
    <dbReference type="GeneID" id="9675677"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_64367"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_64367"/>
    <dbReference type="eggNOG" id="ENOG502SHCN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040908_3_2_1"/>
    <dbReference type="InParanoid" id="C7ZKM4"/>
    <dbReference type="OMA" id="FWITEMA"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF3">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988197" description="Asl1-like glycosyl hydrolase catalytic domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="3">
        <location>
            <begin position="26"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU35434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="314" mass="35073" checksum="6EA605396832EA4E" modified="2009-10-13" version="1">MRRLSTFYLFHFLSLADCIDLTSKRGLAFHGDKHESDNELLLSNNSEIAWYYTWSLWPSDEIGQSLPFVPLIHGLDDASDSELKSRLNKLPDSSTHLLSFNEPDGETDTGGSSISAKDAARSYMSNIAPLRNSTNSRQWNISHPSVTGSPRGLEWLRDFNESCYDIDDDGCPTDFVAVHWYGDTPGLENWLQTLQEFYNETAPEAQFWITELALPKEDEEATLSMMNESLRKLDSLDSVQAYAWFGAFRSDEANEWTGDSVSLFDDDGGLTKLGVEYLGGESKGFEEGMSGGLRLAPTSSLVLGVLMIASFLIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZL31</accession>
    <name>C7ZL31_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_78306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698942">
        <property type="protein sequence ID" value="EEU35335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041048.1">
        <property type="nucleotide sequence ID" value="XM_003041002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZL31"/>
    <dbReference type="STRING" id="660122.C7ZL31"/>
    <dbReference type="GeneID" id="9675526"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78306"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78306"/>
    <dbReference type="eggNOG" id="ENOG502SNW8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_727695_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZL31"/>
    <dbReference type="OMA" id="DFMITIP"/>
    <dbReference type="OrthoDB" id="5421247at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="316" mass="34833" checksum="F653520CC1DC02D3" modified="2009-10-13" version="1">MAPLLTFAQLEQAALYVVRLIADTPGLENTRLAIIGDLAVTKYLPNHGRPASIDLVISKSSSPGRVRKEIVGHPITPLIEKSGAVFYRHTSGWEIEVKLIPDWLCPYLPASARRVRDVTGEATLPYTSLQDLIVFKMDACGLHENDASKRRDACDAAALLELASEHGALNLDEDQAERAEEALADMVEFSDPEHDKNWWQRCLGMVSDKPRTPQEILSDLADRPQTASSSRSSIHSSISRASSYASTHSSTSSISSVGMDEKPSMAEKNGRPRKMSITKKTPRHKRHTSITGLEVHMHRLDLERPASPGIALTNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZL55</accession>
    <name>C7ZL55_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_97942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698943">
        <property type="protein sequence ID" value="EEU35256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040969.1">
        <property type="nucleotide sequence ID" value="XM_003040923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZL55"/>
    <dbReference type="GeneID" id="9675363"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_97942"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_97942"/>
    <dbReference type="eggNOG" id="ENOG502RXYW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030888_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZL55"/>
    <dbReference type="OMA" id="HTDHLKK"/>
    <dbReference type="OrthoDB" id="5394233at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="473"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="585" mass="62873" checksum="D31D608A73B7422C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZL63</accession>
    <name>C7ZL63_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Branched-chain amino acid aminotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_97945</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698943">
        <property type="protein sequence ID" value="EEU35261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040974.1">
        <property type="nucleotide sequence ID" value="XM_003040928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZL63"/>
    <dbReference type="STRING" id="660122.C7ZL63"/>
    <dbReference type="GeneID" id="9675379"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_97945"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_97945"/>
    <dbReference type="eggNOG" id="KOG0975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020844_5_0_1"/>
    <dbReference type="InParanoid" id="C7ZL63"/>
    <dbReference type="OMA" id="VNTTNAC"/>
    <dbReference type="OrthoDB" id="25921at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000002">
        <property type="entry name" value="D-alanine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050571">
        <property type="entry name" value="Class-IV_PLP-Dep_Aminotrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42743">
        <property type="entry name" value="AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42743:SF11">
        <property type="entry name" value="AMINODEOXYCHORISMATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU35261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="38129" checksum="36997C25F2BF3911" modified="2009-10-13" version="1">MTGQNTADKGSGSTHSSVPNAKNETIRVGIRDGVTGEFKLVPRAEAVVSVFDSNFLIGDGIWEGIRANKGRVQFAREHINRLFQSAKAMYMDLGLSKGDLLRLIHDTLDANDMGRDEHVHIRLVVSRGLKSTPYQNPRVNIGLPLIVIIPESKAVDPNSKSRGLRLATTWVRRGPPDVKDEQWNHISKATDVQACISANVMNVDEALMLDLRGFVKTCNSVNFFIIRDNEVWAPTKDNQMQGITRQKTIDVCRANGITVCELDFTLTEVYGADEAFCTGTFPSQIHVTEVDGRTIGDGKRGPVTERIQKLYLELVGKDVGRPRDEIMAEVTAPRDLSFLKASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLP9</accession>
    <name>C7ZLP9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_82464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698946">
        <property type="protein sequence ID" value="EEU35067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040780.1">
        <property type="nucleotide sequence ID" value="XM_003040734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLP9"/>
    <dbReference type="GeneID" id="9679244"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82464"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82464"/>
    <dbReference type="HOGENOM" id="CLU_1326091_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZLP9"/>
    <dbReference type="OMA" id="TGMSTSY"/>
    <dbReference type="OrthoDB" id="5033007at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU35067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="209" mass="23860" checksum="4A5DCED19EC5FAA0" modified="2009-10-13" version="1">MATKKKTYPSEPVPTDYVSWSSKDKLQWLDSQGYAHDPTINLGDCYRSGAKVTQIFTVITKLLQQVYASFRGKTNQTIWKALSTFLNAYNKSITHLSNDVYSSVASLLTTGQFNNESNLIEPVSISDLPIENEDGTSNMVTTIRDFKEKIWPYFLTVLELLQDKWTWLSKVNPIMNVSYNNLIKAMVDAGETFFLEYQKEQDKSPWAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMS0</accession>
    <name>C7ZMS0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Acyl-CoA desaturase</fullName>
            <ecNumber evidence="16">1.14.19.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">NECHADRAFT_44624</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:19721"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="EC" id="1.14.19.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="16">Expected to bind 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="16"/>
    <dbReference type="EMBL" id="GG698958">
        <property type="protein sequence ID" value="EEU34685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040398.1">
        <property type="nucleotide sequence ID" value="XM_003040352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMS0"/>
    <dbReference type="FunCoup" id="C7ZMS0">
        <property type="interactions" value="951"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZMS0"/>
    <dbReference type="GeneID" id="9678811"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_44624"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_44624"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027359_3_2_1"/>
    <dbReference type="InParanoid" id="C7ZMS0"/>
    <dbReference type="OMA" id="LIWLRYG"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000004">
        <property type="entry name" value="Acyl-CoA desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009160">
        <property type="entry name" value="Acyl-CoA_deSatase_haem/ster-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001522">
        <property type="entry name" value="FADS-1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000345">
        <property type="entry name" value="OLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00476">
        <property type="entry name" value="FATTY_ACID_DESATUR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="15 16" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 16" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16" id="KW-0408">Iron</keyword>
    <keyword evidence="4 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="334"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEU34685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="452" mass="51103" checksum="434C077432420344" modified="2009-10-13" version="1">MCPDGTTDYKPLRGRPRDINGTHIQDIPLTWGNWYKKVDWLNTTFIIFIPAIGLMSSYWVALHPYTAIFSAIYYFNTGLGITAGYHRLWSHHSFKATLPLQIYLAAMGAGAVEGSIRWWVKGHRAHHRYTDTDQDPYSVNKGFLYSHLGWMVMKQNPKRLGRTDISDLNEDPVVAWQHCHFLSCVVVMAIVFPTLICGLGWGDWSGGFVYAGILRIFTVQQATFCVNSLAHWLGDQPFDDCRSPRDHFVTALITLGEGYHNFHHEFPSDYRNTIEWWQYDPTKWVIMIWEFFGLAYDLKQLRSNEIEMGRTQQLQKKLEHKRAAIDWGTPLGQLPVIGWDDFIRRSKEGEALVVIAGIVHNVADFMKDHPGGKALISSGIGKDVTAIFNGGVYNHSNAAHNFLCAMRVGLLRGGCEVEVWKHHINDLAGHGIRPAGGQATKIVQPIQGAETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMW6</accession>
    <name>C7ZMW6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_34831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698959">
        <property type="protein sequence ID" value="EEU34640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040353.1">
        <property type="nucleotide sequence ID" value="XM_003040307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMW6"/>
    <dbReference type="GeneID" id="9678780"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_34831"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_34831"/>
    <dbReference type="eggNOG" id="ENOG502SJ3Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035244_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZMW6"/>
    <dbReference type="OMA" id="HVLGHWD"/>
    <dbReference type="OrthoDB" id="10039566at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022185">
        <property type="entry name" value="DUF3712"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046368">
        <property type="entry name" value="Tag1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12505">
        <property type="entry name" value="DUF3712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU34640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="438" mass="48801" checksum="D70EA8B76212E292" modified="2009-10-13" version="1">MTSDRVNVESERAVSPLDETARTDAAPAADVQSDNASSDDHVRDKVVPGPSKRQKLKQHFGRFKWWYLLGLIILLAILLPLFFKVIIPAIIQNILNGQKLQITSGALQALSPTHVNMSLFTYLDTPLGVKIDPVDLYLYNKNTNPYSPFFKLHLPEQHVNHKTDLVITNQTLLVTNETELLVWFNQFFDQPKVKLSLQGEPTIHLGTLKYKRSLEKTIEVPSLTYLDGFGLRDLEFMLKSNDTKFNMKGHLNIPNSGVLTLGLGNLTFNLMSGETRIGLVHLYDLQLRPGNNSVPFDGNFFFDELVPNLSEILDSQQEPLSHGYIELAATGNSTIVNGEHVKYIEGVLNRKHIKFTVPVITLLGDVVGGLLGADQGSLLGIFGGAIGNSTLFEHLLGHWEGESSAGNRTSARSVMKRSQSSRPWVWNLLRLGLKARSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZN62</accession>
    <name>C7ZN62_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_88842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698963">
        <property type="protein sequence ID" value="EEU34548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040261.1">
        <property type="nucleotide sequence ID" value="XM_003040215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZN62"/>
    <dbReference type="GeneID" id="9678078"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88842"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88842"/>
    <dbReference type="HOGENOM" id="CLU_538712_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZN62"/>
    <dbReference type="OrthoDB" id="10333542at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU34548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="506" mass="58230" checksum="25AAF218B3B37109" modified="2009-10-13" version="1">MTSKAGPSAGPRRRRDSWPQYRYRRPTTTEPDAPLVSPRPRPFLALVNALEFITFCLLVSVFIAILLRYMAQPSAVPLPIHRPIAQLPSTLRSFIPPPTSYGHPTSYIPELKYVYEYGIQDLCHYPLKWIRERKRYWPDAGGLYDHEIWADAPKDAPGKLYPLDEVGMDELGRFCEATLDEARTLRVMSREIMHRLEQAHKDSVETIYSIATHLAKLHRQLSSRNKTSSDDDLVLFKYLSELNALGYAEWVEKVSVLDPSLPKSGQYRRKNHRAFETEEVTIRRSQLKLYSLEMLASQLSDFSDLALLLNSHITTLVTRLKPLIIDRKNKKQMCLTGWFDSLPPLLLEAEDASRLASDQAGSLRQSISQVDALRLSLGGFLRGGNKHNGGYEMPYEGHIRQLSLVRNDTVLQGDHWQATWAWMELDTRDWATSRALSTWGAMVANLRKLLPRHPIRLPPIERQYKALRDAFNIAGKEMRDWVSLYPHQLSDLNQRSMQLNKSERYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZND9</accession>
    <name>C7ZND9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Potassium transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_94790</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
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            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003040108.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="9677995"/>
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    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94790"/>
    <dbReference type="eggNOG" id="KOG1341">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_005947_4_1_1"/>
    <dbReference type="InParanoid" id="C7ZND9"/>
    <dbReference type="OMA" id="NNHPRDV"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
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        <property type="entry name" value="Trk1_fungi"/>
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    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
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        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
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        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="471"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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        <location>
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            <end position="606"/>
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    </feature>
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            <begin position="142"/>
            <end position="209"/>
        </location>
    </feature>
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        <location>
            <begin position="165"/>
            <end position="181"/>
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    </feature>
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        <location>
            <begin position="182"/>
            <end position="196"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU34441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="675" mass="75799" checksum="DB6974764F89C6B9" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNM2</accession>
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        <recommendedName>
            <fullName evidence="15">DUF221 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_96579</name>
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        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
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            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="nhe:NECHADRAFT_96579"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_96579"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Csc1-like"/>
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    </dbReference>
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        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
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    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF53">
        <property type="entry name" value="DUF221 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <location>
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            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="497"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="541"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="587"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="652"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="699"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="727"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="26"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="197"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="447"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="10">
        <location>
            <begin position="868"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="265"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="770"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="292"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="770"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="790"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU34202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="967" mass="110597" checksum="F51725ECC02082B4" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNV7</accession>
    <name>C7ZNV7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dipeptidase domain containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_85557</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C69 family. Secernin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039781.1">
        <property type="nucleotide sequence ID" value="XM_003039735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNV7"/>
    <dbReference type="STRING" id="660122.C7ZNV7"/>
    <dbReference type="GeneID" id="9677912"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85557"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85557"/>
    <dbReference type="eggNOG" id="ENOG502S9QK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029923_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZNV7"/>
    <dbReference type="OMA" id="RYLSMEY"/>
    <dbReference type="OrthoDB" id="5175656at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070004">
        <property type="term" value="F:cysteine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005322">
        <property type="entry name" value="Peptidase_C69"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994:SF17">
        <property type="entry name" value="LD30995P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994">
        <property type="entry name" value="SECERNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03577">
        <property type="entry name" value="Peptidase_C69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988259" description="Dipeptidase domain containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU34068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="514" mass="57306" checksum="4E45B4611FD9A08C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPJ7</accession>
    <name>C7ZPJ7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycolipid transfer protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_64023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040074.1">
        <property type="nucleotide sequence ID" value="XM_003040028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZPJ7"/>
    <dbReference type="STRING" id="660122.C7ZPJ7"/>
    <dbReference type="GeneID" id="9677746"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_64023"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_64023"/>
    <dbReference type="eggNOG" id="KOG3221">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079400_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZPJ7"/>
    <dbReference type="OMA" id="EMHGAEW"/>
    <dbReference type="OrthoDB" id="205255at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000001">
        <property type="entry name" value="Pleckstrin domain-containing family A member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF25">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="33"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU34361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="206" mass="22619" checksum="60D853D930BEFC78" modified="2009-10-13" version="1">MSTATYPPGGTIVQTLKRTYSDVPVDEANGNAVSTTEFLEASEAMTTIFDAIGGVAFGPVKKDILSNIEKLRARQAAAPAESGNIQDLCRNELKTKKHVATEGALWLIRGLDFTCQALVRNVANPSEELADSFRTSYAETLKPHHSFLVKPIFSAAMSAVPYRKDFYAKLGETPELVQTELDAYLAAFTRVVNILKEFINSKEAKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPS5</accession>
    <name>C7ZPS5_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_82238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698972">
        <property type="protein sequence ID" value="EEU33973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039686.1">
        <property type="nucleotide sequence ID" value="XM_003039640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZPS5"/>
    <dbReference type="GeneID" id="9677518"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82238"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82238"/>
    <dbReference type="HOGENOM" id="CLU_1960153_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZPS5"/>
    <dbReference type="OrthoDB" id="10434309at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU33973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="128" mass="14180" checksum="A12ED42D4BF1A5B1" modified="2009-10-13" version="1">MLVPDENSKQIDPGFSWKTTSLSPPFAHPVHKYANDNYSQAEAMRTPALQLWIASIRGLVCRPVEKYVGTKVRIDDELHGIATTRLAEHENEITDLVLDSCRGPGDEEKRSFTLLTISLVSSGGLITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPS8</accession>
    <name>C7ZPS8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PD-(D/E)XK nuclease-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_82241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698972">
        <property type="protein sequence ID" value="EEU33976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039689.1">
        <property type="nucleotide sequence ID" value="XM_003039643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZPS8"/>
    <dbReference type="GeneID" id="9677512"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82241"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82241"/>
    <dbReference type="eggNOG" id="ENOG502SSXD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_614061_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZPS8"/>
    <dbReference type="OMA" id="LAIWIEM"/>
    <dbReference type="OrthoDB" id="5244165at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046797">
        <property type="entry name" value="PDDEXK_12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20516">
        <property type="entry name" value="PDDEXK_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PD-(D/E)XK nuclease-like" evidence="2">
        <location>
            <begin position="206"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU33976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="446" mass="50006" checksum="0C70F6EA98930BF3" modified="2009-10-13" version="1">MEYSQIEAWIAEASKFPPFLEPSSPLLSLPEPTTSTKRKRPHETTSIMSPPFSEDLPFPVDPRDISRPESPTKRRRVDQSSSTSAPNASFPLRPTTDTRSEYSAGTGDGHGNTWMTQSAPAVYMPPATPSKKSSRRSPVRDMADLALAEKHIKHIVLKRLDQLTPDVLPLFERSKEASELRNIVPRQVHHAITADRGPLEKALDDHTFYDAESWAKEHGANPWNAFDELQELRLVCERTQEAIELNLPEPCWNARIHERLLDVALKPFENLSHWDVTRATINKPYLGKHRSGVDLQAKLVDFCITLSGVTVRDVYDRLAAANDPQSINHSSTAPLRYQPIAVSIETKVQAGSTEEGKAQLSVWATSHLKRLRLLSVTSSKHITVDTTLPLVQVNGGVWTLLFLRDGETVQLIETVMIGDTKTVLGCYQVVAFLRHLGHWALTVYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZRC4</accession>
    <name>C7ZRC4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_89503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699060">
        <property type="protein sequence ID" value="EEU33431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039144.1">
        <property type="nucleotide sequence ID" value="XM_003039098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZRC4"/>
    <dbReference type="GeneID" id="9666665"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89503"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89503"/>
    <dbReference type="HOGENOM" id="CLU_2159052_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZRC4"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU33431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="111" mass="12454" checksum="BD58BC2C5D3D08E3" modified="2009-10-13" version="1">MKAFMRASIGNDDIADYLTPEFGLRCRRLSPSNEYMEGFTKGNAQLVKSSVTRFTKTVSYSVWMNQWSKDGSFVIKRLGNGKIVKSIKGRTGKSGNQIAQPASFSESWFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7YGW1</accession>
    <name>C7YGW1_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_74760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053525.1">
        <property type="nucleotide sequence ID" value="XM_003053479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YGW1"/>
    <dbReference type="GeneID" id="9664321"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74760"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74760"/>
    <dbReference type="eggNOG" id="ENOG502RZ72">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035633_2_0_1"/>
    <dbReference type="InParanoid" id="C7YGW1"/>
    <dbReference type="OMA" id="FCAPAFH"/>
    <dbReference type="OrthoDB" id="5360701at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU47812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="411" mass="44876" checksum="2D6ECC48C7DC97FC" modified="2009-10-13" version="1">MRRASPRQIGNVCHRCAFAPARAVANQAFLSGALLSSTRHVRNSTLKPLGVRWVATSPYPDLNIQPPDAASVPRQLTDPAQLAKIVGDNTNKFLSTDGIPAKQLTSAALETCLRAAEALQPQVRKAEAQSRGSTSKLMELGAERTGNRPIKMDAQLADSIKKISYSAYTIISHPNVEITPEFLELYVVIQATLGRPESLPAVLDMFASKKKPVVKNGIVQYVASNPNAAIKAVQSDVADMALQSAIDAKNLDSALGIVEASFSLPAFKRQKLLKHATTPALALATLPFGIFGLASAYAAYWQNTMDITTATGIGFAGISGYFFVVGSMGLIAKLSNKDQMKRVTWAPGTPLRYRWLREEERAAMDKIACAWGFKEPWRHGEESGPEWEGLKEYMGYRQMILDRVEFMEGMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7YGZ9</accession>
    <name>C7YGZ9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase family 69</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_90076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053542.1">
        <property type="nucleotide sequence ID" value="XM_003053496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YGZ9"/>
    <dbReference type="STRING" id="660122.C7YGZ9"/>
    <dbReference type="GeneID" id="9676874"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90076"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90076"/>
    <dbReference type="eggNOG" id="ENOG502RJAT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040564_1_0_1"/>
    <dbReference type="InParanoid" id="C7YGZ9"/>
    <dbReference type="OMA" id="YIASMHW"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF7">
        <property type="entry name" value="EXPORT PROTEIN (CAP59), PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU47829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="46797" checksum="B7A4B970C2225141" modified="2009-10-13" version="1">MISHGNRLFLRRLLRSRTTKILLVLLVVVNILDVLRIHRNILDADRTPTPKLSQPAERIYIASMHFNNEDILKKHWNNAVIELAKTLHPENVFVSVYESGSWDNSKAELLKLDKELERLGVPHRVEVSDVTHENELNAENKDEGWIDTARGKRELRRIPYLAKLRNKTLRDLLELHKKGTRFDKVLFLNDVVFTTDDVLKLLDTNGGDYAAACSLDFSKPPSYYDTFALRDAAGQSHTTQSWPYFKSSASRNALVNHLDAVPVTSCWNGIVVMPAEPFVSSSKLRFRGVADSLAEHHLEGSECCLIHADNPLSKTRGVYLNPRVRVGYNMAAYQAVHPEEGAWVSVWDIFSGLWINRLKRWTVVTFEKWVVRRRITKWEKEGLGRREPGEFCLINEMQVLVARGWAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7YH13</accession>
    <name>C7YH13_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase II degradation factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">NECHADRAFT_123079</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054266.1">
        <property type="nucleotide sequence ID" value="XM_003054220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YH13"/>
    <dbReference type="STRING" id="660122.C7YH13"/>
    <dbReference type="GeneID" id="9664422"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_123079"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_123079"/>
    <dbReference type="eggNOG" id="ENOG502S359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008092_0_0_1"/>
    <dbReference type="InParanoid" id="C7YH13"/>
    <dbReference type="OMA" id="MYQNQFP"/>
    <dbReference type="OrthoDB" id="5396806at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14368">
        <property type="entry name" value="CUE_DEF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041803">
        <property type="entry name" value="DEF1_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051833">
        <property type="entry name" value="TC-DDR_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308:SF13">
        <property type="entry name" value="PROTEIN LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308">
        <property type="entry name" value="UBIQUITIN ASSOCIATED PROTEIN 2-LIKE/LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="CUE" evidence="17">
        <location>
            <begin position="66"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="99"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="410"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="733"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="315"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="334"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="385"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="476"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="539"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="590"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="622"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="654"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="737"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="789"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="888"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="901"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEU48553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="930" mass="97130" checksum="52E46FF2E67AD81D" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHD6</accession>
    <name>C7YHD6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secondary alcohol dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_74934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054326.1">
        <property type="nucleotide sequence ID" value="XM_003054280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YHD6"/>
    <dbReference type="FunCoup" id="C7YHD6">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YHD6"/>
    <dbReference type="GeneID" id="9674487"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74934"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74934"/>
    <dbReference type="eggNOG" id="ENOG502SB51">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072829_0_0_1"/>
    <dbReference type="InParanoid" id="C7YHD6"/>
    <dbReference type="OMA" id="WTDGTFQ"/>
    <dbReference type="OrthoDB" id="548474at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038966">
        <property type="entry name" value="TMA17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422:SF1">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU48613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="23298" checksum="53D61E4BD465A379" modified="2009-10-13" version="1">MSTSTSADTRPIAPDRFAAALKDLSVGMLHLKVLEIRNSIAHLEYSNDQLKPFAEGNATALSDSSTPAVAQEPDQDCIDAIKENEVVIDRMAERIALIRAEVEERGISWTEFQSRDEIASRGEGDGEKATVEVNGDTQPSETATATSAPTESRHEAWSDGTFQTGTIRNGEIHMDREAGRPEGGSLSDEQLQRALEERMRNLETDDDEGGMHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7YI18</accession>
    <name>C7YI18_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2470 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_75164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053727.1">
        <property type="nucleotide sequence ID" value="XM_003053681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YI18"/>
    <dbReference type="GeneID" id="9664751"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75164"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75164"/>
    <dbReference type="eggNOG" id="ENOG502RZUI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081019_0_0_1"/>
    <dbReference type="InParanoid" id="C7YI18"/>
    <dbReference type="OMA" id="VECFFFD"/>
    <dbReference type="OrthoDB" id="5553410at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.10">
        <property type="entry name" value="PNP-oxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019595">
        <property type="entry name" value="DUF2470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037119">
        <property type="entry name" value="Haem_oxidase_HugZ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37783">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04315)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37783:SF1">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04315)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10615">
        <property type="entry name" value="DUF2470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2470" evidence="2">
        <location>
            <begin position="9"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU48014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="221" mass="25179" checksum="7575229BA79DCC43" modified="2009-10-13" version="1">MASADDARKKRIVSHMNQDHTREISYYLRHYAHLSAGAASSPTLRDVDLNGMTIRSKDGRDHFIPFTPPLKGWGEAKDRIIEMAVEAREALGLSDVVIEGYRPPEGFGIIVTGSVIFYFFCAATLPWVQPGTDVWRLLETGFPGGPTFYSWLVNAIFWPVVGIHVVECYFFDRKLQRHGVERLSGQWWLWLSNCFVEGFPSFKRVDGIVARKQQEKNGKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7YI53</accession>
    <name>C7YI53_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein SYM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_73409</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053748.1">
        <property type="nucleotide sequence ID" value="XM_003053702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YI53"/>
    <dbReference type="FunCoup" id="C7YI53">
        <property type="interactions" value="599"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YI53"/>
    <dbReference type="GeneID" id="9664765"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_73409"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_73409"/>
    <dbReference type="eggNOG" id="KOG1944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049109_8_1_1"/>
    <dbReference type="InParanoid" id="C7YI53"/>
    <dbReference type="OMA" id="WYQSKLA"/>
    <dbReference type="OrthoDB" id="430207at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF17">
        <property type="entry name" value="PROTEIN MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU48035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="19759" checksum="63C8258712199A22" modified="2009-10-13" version="1">MASFIRWYNARLAARPLLTQSVTTAVLFATGDITAQQLVEKKGVEKHDLVRTGRMALYGGFVFGPVATTWFGFLARNVNARNRKVETLARVACDQLAFAPVMIGVFLGSMATMEGNDPKKRIETTWWPALKANWMLWPFVQVINFSFIPLQHRVFFANIVSIGWNSYLSWINNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIX8</accession>
    <name>C7YIX8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_30646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054599.1">
        <property type="nucleotide sequence ID" value="XM_003054553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIX8"/>
    <dbReference type="FunCoup" id="C7YIX8">
        <property type="interactions" value="916"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YIX8"/>
    <dbReference type="GeneID" id="9676520"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_30646"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_30646"/>
    <dbReference type="eggNOG" id="KOG2048">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002392_2_1_1"/>
    <dbReference type="InParanoid" id="C7YIX8"/>
    <dbReference type="OMA" id="MWDVELP"/>
    <dbReference type="OrthoDB" id="8883818at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046351">
        <property type="entry name" value="UTP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU48886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="879" mass="96592" checksum="58495D4CE920A7C7" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJ37</accession>
    <name>C7YJ37_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycerol uptake protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_75542</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003054581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJ37"/>
    <dbReference type="FunCoup" id="C7YJ37">
        <property type="interactions" value="166"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YJ37"/>
    <dbReference type="GeneID" id="9663696"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75542"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75542"/>
    <dbReference type="eggNOG" id="KOG3860">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021430_1_1_1"/>
    <dbReference type="InParanoid" id="C7YJ37"/>
    <dbReference type="OMA" id="GWHRSYN"/>
    <dbReference type="OrthoDB" id="420606at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051085">
        <property type="entry name" value="MB_O-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285:SF18">
        <property type="entry name" value="PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE RASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="544"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="585"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU48914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="621" mass="72323" checksum="CF203AEFB86E7969" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJD0</accession>
    <name>C7YJD0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_75635</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053966.1">
        <property type="nucleotide sequence ID" value="XM_003053920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJD0"/>
    <dbReference type="GeneID" id="9663823"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75635"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75635"/>
    <dbReference type="eggNOG" id="ENOG502QPW5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055465_1_0_1"/>
    <dbReference type="InParanoid" id="C7YJD0"/>
    <dbReference type="OMA" id="MMILWLA"/>
    <dbReference type="OrthoDB" id="5241662at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF4">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="21"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="214"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="218"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="283"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU48253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="356" mass="39691" checksum="CB44A11AAE4C6DD4" modified="2009-10-13" version="1">MEQPVEKPQGDHVLHTPLWIMIIRGFQFLISLIIVGLCGRMIHDAYLDEEGFSLAVSILTWLAVAYVVFTEKIPSLRGAYHILAVLIVDGLLIILWLAAWAATASRRSKYVVPVTVGDCYDDGSVVNSKSCDVVFKRAIHTKRDVILTKIGLAMLSSIAGLGALVWVLFIATFVWTLLMFLRGRKEGRFAVGSSSTGTPTDNYQMENKISEAQPMNAPPQQFQGQPQPQQFQQPAPNGQFAPQQQPQFSPQPTPAPAYQQPPFQQPQSPYQQQGAYPPPQAPYSPQDQQQQQQQQQFQGQPTYGQYPQQQPQQAPYQQPAPQTYGSELDGQNQYTAPPPAVSPPPQQYQQQPYAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7YK77</accession>
    <name>C7YK77_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Suppressor of forked domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_32074</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PRP39 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053406.1">
        <property type="nucleotide sequence ID" value="XM_003053360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YK77"/>
    <dbReference type="FunCoup" id="C7YK77">
        <property type="interactions" value="297"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YK77"/>
    <dbReference type="GeneID" id="9664120"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_32074"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_32074"/>
    <dbReference type="eggNOG" id="KOG1258">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007434_3_1_1"/>
    <dbReference type="InParanoid" id="C7YK77"/>
    <dbReference type="OMA" id="IISWANL"/>
    <dbReference type="OrthoDB" id="10265668at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140727">
        <property type="term" value="P:siRNA-mediated pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000451">
        <property type="entry name" value="mRNA splicing protein (Prp39), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000064">
        <property type="entry name" value="Putative pre-mrna-processing factor 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059164">
        <property type="entry name" value="HAT_PRP39_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204">
        <property type="entry name" value="PRE-MRNA PROCESSING PROTEIN PRP39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204:SF5">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23241">
        <property type="entry name" value="HAT_PRP39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23240">
        <property type="entry name" value="HAT_PRP39_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU47693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="62585" checksum="78D0E07C835DCEAF" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7YKU7</accession>
    <name>C7YKU7_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_20901</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052392.1">
        <property type="nucleotide sequence ID" value="XM_003052346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YKU7"/>
    <dbReference type="GeneID" id="9671386"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_20901"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_20901"/>
    <dbReference type="eggNOG" id="ENOG502QQ8X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012585_1_0_1"/>
    <dbReference type="InParanoid" id="C7YKU7"/>
    <dbReference type="OMA" id="HLYGTPW"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7580" evidence="3">
        <location>
            <begin position="170"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="2">
        <location>
            <begin position="646"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU46679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="940" mass="105570" checksum="ED947715B0A6AE58" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7YKU9</accession>
    <name>C7YKU9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_35754</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052856.1">
        <property type="nucleotide sequence ID" value="XM_003052810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YKU9"/>
    <dbReference type="GeneID" id="9671387"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_35754"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_35754"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_3_1"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF34">
        <property type="entry name" value="PROTEIN HOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="54"/>
            <end position="533"/>
        </location>
    </feature>
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        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEU47143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="551" mass="60423" checksum="3EA6948059B41F43" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7YKZ2</accession>
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        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_77345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
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        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
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    <dbReference type="GeneID" id="9671405"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77345"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77345"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_352690_0_0_1"/>
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    <dbReference type="OrthoDB" id="5100721at2759"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="entry name" value="HET"/>
    </dbReference>
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        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="260"/>
            <end position="386"/>
        </location>
    </feature>
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        <location>
            <begin position="630"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="783"/>
        </location>
    </feature>
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        <location>
            <begin position="699"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="723"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="749"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="763"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU46705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="797" mass="88783" checksum="93A22B56C8287B8A" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C7YMJ8</accession>
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        <recommendedName>
            <fullName evidence="7">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_67504</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
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                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
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                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
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            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the peptidase C19 family.</text>
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    </dbReference>
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    <dbReference type="FunCoup" id="C7YMJ8">
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    </dbReference>
    <dbReference type="STRING" id="660122.C7YMJ8"/>
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    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_67504"/>
    <dbReference type="eggNOG" id="KOG1868">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005922_0_0_1"/>
    <dbReference type="InParanoid" id="C7YMJ8"/>
    <dbReference type="OMA" id="PFVHTYE"/>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
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    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
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    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
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    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF46">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="382"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="677"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="291"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="587"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="616"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU46961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1054" mass="117743" checksum="2624597D9D6F4E54" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7YMJ9</accession>
    <name>C7YMJ9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_59265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053174.1">
        <property type="nucleotide sequence ID" value="XM_003053128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YMJ9"/>
    <dbReference type="FunCoup" id="C7YMJ9">
        <property type="interactions" value="870"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YMJ9"/>
    <dbReference type="GeneID" id="9671207"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_59265"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_59265"/>
    <dbReference type="eggNOG" id="KOG1180">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_45_2_1"/>
    <dbReference type="InParanoid" id="C7YMJ9"/>
    <dbReference type="OMA" id="HADPEHS"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="110"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU47461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="696" mass="76935" checksum="1634ED6974031FE0" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7YMN4</accession>
    <name>C7YMN4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal protein L37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_59304</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053190.1">
        <property type="nucleotide sequence ID" value="XM_003053144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YMN4"/>
    <dbReference type="FunCoup" id="C7YMN4">
        <property type="interactions" value="565"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YMN4"/>
    <dbReference type="GeneID" id="9671226"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_59304"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_59304"/>
    <dbReference type="eggNOG" id="KOG3475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150908_0_0_1"/>
    <dbReference type="InParanoid" id="C7YMN4"/>
    <dbReference type="OMA" id="RMAYLKH"/>
    <dbReference type="OrthoDB" id="10259236at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000001">
        <property type="entry name" value="Ribosomal protein L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00547">
        <property type="entry name" value="Ribosomal_eL37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_eL37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018267">
        <property type="entry name" value="Ribosomal_eL37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003214">
        <property type="entry name" value="PRK04179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01077">
        <property type="entry name" value="RIBOSOMAL_L37E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="53"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU47477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="93" mass="10639" checksum="8534F186472CF2DF" modified="2009-10-13" version="1">MTKGTSSFGKRHNKTHTLCRRCGRRSLHIQKHECAACGYPAAKTRKYNWSEKAKRRKTVGTGRTRYLKDVSRRFKNGFQTGQPKGARGINKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7YMW8</accession>
    <name>C7YMW8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7924 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_35677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053233.1">
        <property type="nucleotide sequence ID" value="XM_003053187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YMW8"/>
    <dbReference type="STRING" id="660122.C7YMW8"/>
    <dbReference type="GeneID" id="9664224"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_35677"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_35677"/>
    <dbReference type="eggNOG" id="ENOG502SQPH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036509_0_0_1"/>
    <dbReference type="InParanoid" id="C7YMW8"/>
    <dbReference type="OMA" id="HEEMPEC"/>
    <dbReference type="OrthoDB" id="5426775at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057684">
        <property type="entry name" value="DUF7924"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42470">
        <property type="entry name" value="VAST DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42470:SF1">
        <property type="entry name" value="VAST DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25545">
        <property type="entry name" value="DUF7924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7924" evidence="1">
        <location>
            <begin position="116"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU47520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="295" mass="33399" checksum="0AA2BE60507CF47A" modified="2009-10-13" version="1">MDDLGNISGITGPTATTKGTLVESPLYRVQNLRANGIYFNHPCDRPPEHITNFVNQMRRDRGSPGPSADDISQDRDLHNLSLGTSESEVATYFLARVFVNPGSSDYLKRNEKQQMKRNHVPDAGTNHKVSTPVPDTLYGYRDETAFHQQQAQLLPMYKEAMANNQGLMYPFFVIEFKGDNGSLWAATNQCLGGAATCINMVEKLNDRFKQRMSNNPINSADPINSAVFSIAMSGTEARLYVSWKENERDYFMAHVDSFLLQDPEHHAKFYNFVHNILDWGRGERLEQIRSCLDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNM8</accession>
    <name>C7YNM8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-oxoacyl-[acyl-carrier-protein] synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_38302</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 11">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051859.1">
        <property type="nucleotide sequence ID" value="XM_003051813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNM8"/>
    <dbReference type="FunCoup" id="C7YNM8">
        <property type="interactions" value="509"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YNM8"/>
    <dbReference type="GeneID" id="9670836"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_38302"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_38302"/>
    <dbReference type="eggNOG" id="KOG1394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_69_2_1"/>
    <dbReference type="InParanoid" id="C7YNM8"/>
    <dbReference type="OMA" id="QIGHCLG"/>
    <dbReference type="OrthoDB" id="5334845at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000015">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000024">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005589">
        <property type="entry name" value="PRK07314.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712:SF336">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="POLYKETIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="12">
        <location>
            <begin position="1"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="10">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU46146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="428" mass="45194" checksum="AAA5BA10ADFD264F" modified="2009-10-13" version="1">MRRVVVTGLGAITPLGVGVRRTWTRLLAGESGIVSVADLEPRARWTELTSTVAGIVPSGEGEGKWRASDWVSMTEQRRMSKFTQYAIAASDMALKDAGWEPKDERELEETGVCLGSGIGNLEDIYEMSLAHDKGGYKKVSPLFVPKILINMAAGHIAMKYGLQGPNHAVTTACTTGAHSIGDASRFIAMGDADVMIAGGSESCIHPLTFAGFGRARSLSTAYNDNPQASCRPFDADRNGFVVAEGAAVCVLEELEHAKARGARVYAEIKGYGCSGDAYHMTAPREDGRGALLAMKKALKNAGIKPSQIDYVNAHATATQVGDIAETSAIRSLMMGDEGHSRESDITVSSTKGAVGHLLGAAGAIEALFSILAIHEGIVPPTLNLEKPDVGAAFNFVPKEAQEKDIGVAISNSFGFGGTNSSLVFSKFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNR3</accession>
    <name>C7YNR3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome assembly factor mrt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_79397</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 6">Associates with the pre-60S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051874.1">
        <property type="nucleotide sequence ID" value="XM_003051828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNR3"/>
    <dbReference type="FunCoup" id="C7YNR3">
        <property type="interactions" value="1067"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YNR3"/>
    <dbReference type="GeneID" id="9670856"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79397"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79397"/>
    <dbReference type="eggNOG" id="KOG0816">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071690_0_0_1"/>
    <dbReference type="InParanoid" id="C7YNR3"/>
    <dbReference type="OMA" id="LEWAENY"/>
    <dbReference type="OrthoDB" id="10262308at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05796">
        <property type="entry name" value="Ribosomal_P0_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000005">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000003">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033867">
        <property type="entry name" value="Mrt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051742">
        <property type="entry name" value="Ribosome_Assembly_uL10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841:SF1">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 MRTO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="7">
        <location>
            <begin position="125"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU46161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="242" mass="26877" checksum="77A9C52CB1C562BC" modified="2009-10-13" version="1">MPKSKRAKVVHLTQVSKKTRENKDKLFENIRNEIPEYQTCFVFSVDNMRNSYLKEVRRELSDCRLFFGKTKLMAKALGQTPEEAIAPGIEGITKHLAGTVGLLLTNRPAEEILAYFDNLAPVDFARAGVAASRGFSLPAGVLYATGGEVPAEHDVPLEHTIEPELRRLGVPTRMVKGRVVLGDESGEGEDYVVCKEGDILDSRQTRLLKLFSVCLSEFKVKVLAYWSAATSEVTEVNAMDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C7YP46</accession>
    <name>C7YP46_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein transport protein SEC24</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein transport protein sec24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">NECHADRAFT_99888</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051946.1">
        <property type="nucleotide sequence ID" value="XM_003051900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YP46"/>
    <dbReference type="FunCoup" id="C7YP46">
        <property type="interactions" value="867"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YP46"/>
    <dbReference type="GeneID" id="9673099"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_99888"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_99888"/>
    <dbReference type="eggNOG" id="KOG1985">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004589_2_1_1"/>
    <dbReference type="InParanoid" id="C7YP46"/>
    <dbReference type="OMA" id="AVECSKQ"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990753">
        <property type="term" value="C:equatorial cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01479">
        <property type="entry name" value="Sec24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041742">
        <property type="entry name" value="Sec24-like_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF39">
        <property type="entry name" value="SECRETORY 24AB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="18">
        <location>
            <begin position="266"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="19">
        <location>
            <begin position="340"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="21">
        <location>
            <begin position="587"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="20">
        <location>
            <begin position="681"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="17">
        <location>
            <begin position="811"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="71"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EEU46233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="945" mass="103252" checksum="BB1145F561994A42" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7YP65</accession>
    <name>C7YP65_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_78650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051957.1">
        <property type="nucleotide sequence ID" value="XM_003051911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YP65"/>
    <dbReference type="STRING" id="660122.C7YP65"/>
    <dbReference type="GeneID" id="9673110"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78650"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78650"/>
    <dbReference type="eggNOG" id="ENOG502R67R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095751_0_0_1"/>
    <dbReference type="InParanoid" id="C7YP65"/>
    <dbReference type="OMA" id="MDIVVHI"/>
    <dbReference type="OrthoDB" id="5088255at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU46244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="229" mass="26549" checksum="B21AADFF3D8B06E0" modified="2009-10-13" version="1">MGSQPQRPPVYTSRYRAASPVLRHLELESAHYPLRDILQANKESFINKAKQVLEHYGIVEGDDTKVDLLHRQMRPYQREPIATLYITTPVIQGRDGIDLHVEMIAPERFQLKNLGPVTGEPRLAGGVWDSVRNMVMEKLNSCEVTRRKWVSIGLFRLGFSDRMEENPITIYIFLSYDSDESRWEEVMVMIENELRERNLDFIEVLLEHNVGWGLGWGEGFGNAYLQDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPS6</accession>
    <name>C7YPS6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_78857</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051615.1">
        <property type="nucleotide sequence ID" value="XM_003051569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YPS6"/>
    <dbReference type="STRING" id="660122.C7YPS6"/>
    <dbReference type="GeneID" id="9668768"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78857"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78857"/>
    <dbReference type="eggNOG" id="ENOG502S8FT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056607_0_0_1"/>
    <dbReference type="InParanoid" id="C7YPS6"/>
    <dbReference type="OMA" id="RSCHWVV"/>
    <dbReference type="OrthoDB" id="329272at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU45902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="268" mass="30304" checksum="9C5C8E53AF36EC4F" modified="2009-10-13" version="1">MATPFISLLEPGKVEEFQRGVPLDQQPSTIPQTFLDAMEVRQNVFVQEQKVPAENEFDSDDNRSCHWVIYASVKKTEEPEITDKAGNVVQHRKSSTRSTPIGTIRLVPFPHDPHPQDGGRYIDGRLQDTDGEQNHMVLTGGVGRPPYIVERETTFHDGQEPYVKLGRLAVIKEFRGHRIAGQVVNAALSWIKSNPSYFDPSIKEVGMKKLGATSDKEIPTWKGLVCVHAQKQVVDVWKKWGFELDEGMGTWWEEGMAHVGMFRRLNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPX4</accession>
    <name>C7YPX4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Calcofluor white hypersensitive protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_60022</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052082.1">
        <property type="nucleotide sequence ID" value="XM_003052036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YPX4"/>
    <dbReference type="FunCoup" id="C7YPX4">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YPX4"/>
    <dbReference type="GeneID" id="9673310"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_60022"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_60022"/>
    <dbReference type="eggNOG" id="KOG3979">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009808_0_0_1"/>
    <dbReference type="InParanoid" id="C7YPX4"/>
    <dbReference type="OMA" id="CVWYFPL"/>
    <dbReference type="OrthoDB" id="68581at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000031">
        <property type="entry name" value="Calcofluor white hypersensitive protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057315">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051916">
        <property type="entry name" value="GPI-anchor_lipid_remodeler"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053912">
        <property type="entry name" value="PGAP2IP_TM_1nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053911">
        <property type="entry name" value="PGAP2IP_TM_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859">
        <property type="entry name" value="CALCOFLUOR WHITE HYPERSENSITIVE PROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859:SF1">
        <property type="entry name" value="PGAP2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23022">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Frag1"/>
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    </dbReference>
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        <property type="entry name" value="DNase I-like"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="551"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="582"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="613"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="650"/>
            <end position="667"/>
        </location>
    </feature>
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        <location>
            <begin position="18"/>
            <end position="226"/>
        </location>
    </feature>
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        <location>
            <begin position="283"/>
            <end position="437"/>
        </location>
    </feature>
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        <location>
            <begin position="457"/>
            <end position="633"/>
        </location>
    </feature>
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        <location>
            <begin position="683"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU46369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="960" mass="108040" checksum="BCE0C7EBDF4C3CF2" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQS9</accession>
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        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_92820</name>
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    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0005096">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF337">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        <location>
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            <end position="485"/>
        </location>
    </feature>
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        <location>
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            <end position="717"/>
        </location>
    </feature>
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        <location>
            <begin position="598"/>
            <end position="612"/>
        </location>
    </feature>
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        <location>
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            <end position="647"/>
        </location>
    </feature>
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        <location>
            <begin position="655"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="693"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU46073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="717" mass="80108" checksum="BC270CD6E63CFFFE" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQZ1</accession>
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        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="5" type="ORF">NECHADRAFT_37841</name>
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    <organism evidence="5 6">
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        <name type="synonym">Fusarium solani subsp. pisi</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
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            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EEU46104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003051771.1"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YQZ1"/>
    <dbReference type="GeneID" id="9672805"/>
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    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_37841"/>
    <dbReference type="eggNOG" id="ENOG502REBM">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002541_1_0_1"/>
    <dbReference type="InParanoid" id="C7YQZ1"/>
    <dbReference type="OMA" id="MFAREQK"/>
    <dbReference type="OrthoDB" id="2123378at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13278">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000311">
        <property type="entry name" value="GTP binding protein (Bud4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012966">
        <property type="entry name" value="AHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052007">
        <property type="entry name" value="Bud4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36100">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36100:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08174">
        <property type="entry name" value="Anillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1307"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="454"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="522"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="606"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="919"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1169"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="54"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="157"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="545"/>
            <end position="555"/>
        </location>
    </feature>
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        <location>
            <begin position="574"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="606"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="645"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="669"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="717"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="919"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="958"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="993"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU46104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1474" mass="164425" checksum="9B2D63902D470232" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRD8</accession>
    <name>C7YRD8_FUSV7</name>
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        <recommendedName>
            <fullName evidence="3">Aminodeoxychorismate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_40658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051153.1">
        <property type="nucleotide sequence ID" value="XM_003051107.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="C7YRD8">
        <property type="interactions" value="144"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YRD8"/>
    <dbReference type="GeneID" id="9667848"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_40658"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_40658"/>
    <dbReference type="eggNOG" id="ENOG502QQMK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020844_6_0_1"/>
    <dbReference type="InParanoid" id="C7YRD8"/>
    <dbReference type="OMA" id="VWLSNGV"/>
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        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
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    </dbReference>
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        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
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        <property type="entry name" value="Aminotransferase-like"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU45440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="30903" checksum="4BD66E7A86028788" modified="2009-10-13" version="1">MSDEFSLFTSLRYDPKLQKLRQQGLNGKGWNFENESPLYMLDFHRDRLLRAATHWNWQPAIDRLSGVSGLQSLAQLINEAVKSPPGTPLRLRIVVSREGDIKVEKFNVPETPLENLLPSRLPVPSSASLADEPTKSPTYTLLVDQTSTLRSEYTHFKTTKRAMYDAAGQRAGVSPTDLAEVLVINQDDGSVMEGTRTTPYFWRDGRWVTPPISAKFSWDEGSGGQDGTSRRWALESRGLAVEQAVNVKSLTDGEECWLSNGVRGFMAATISLRERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7YS56</accession>
    <name>C7YS56_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_41626</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050903.1">
        <property type="nucleotide sequence ID" value="XM_003050857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YS56"/>
    <dbReference type="FunCoup" id="C7YS56">
        <property type="interactions" value="793"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YS56"/>
    <dbReference type="GeneID" id="9668138"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_41626"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_41626"/>
    <dbReference type="eggNOG" id="KOG3235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_7_0_1"/>
    <dbReference type="InParanoid" id="C7YS56"/>
    <dbReference type="OMA" id="LPENYFM"/>
    <dbReference type="OrthoDB" id="25586at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990190">
        <property type="term" value="F:protein-N-terminal-glutamate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU45190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="223" mass="25293" checksum="269D93BF95F1B36D" modified="2009-10-13" version="1">MDIRVLTSADLPLIQHANLENLPENYFLKYYLYHALSWPQLSYVAVDVSRPKKNPYEYPKIVGYVLAKMEEEPTDGVQHGHITSLSVMRTHRRLGIAEKLMRQSQLAMVETFQAKYVSLHVRVSNAAARHLYEDTLGFKNEKTESKYYADGEDAFCMRLDLDEIKAQVDKAIEDEADEHDDEGDAVGEVGRDPEADKKKKKIKVAVGRGLGVGALVEKDESKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C7YTA5</accession>
    <name>C7YTA5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_41555</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051092.1">
        <property type="nucleotide sequence ID" value="XM_003051046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YTA5"/>
    <dbReference type="GeneID" id="9668490"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_41555"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_41555"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010365_5_0_1"/>
    <dbReference type="InParanoid" id="C7YTA5"/>
    <dbReference type="OMA" id="RRWWYEL"/>
    <dbReference type="OrthoDB" id="10006946at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF28">
        <property type="entry name" value="FRP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="253"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="443"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="489"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU45379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="574" mass="62737" checksum="10E383D711B71028" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C7YTR1</accession>
    <name>C7YTR1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_105272</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050379.1">
        <property type="nucleotide sequence ID" value="XM_003050333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YTR1"/>
    <dbReference type="STRING" id="660122.C7YTR1"/>
    <dbReference type="GeneID" id="9675164"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_105272"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_105272"/>
    <dbReference type="eggNOG" id="KOG0653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020695_9_1_1"/>
    <dbReference type="InParanoid" id="C7YTR1"/>
    <dbReference type="OMA" id="TMMIECC"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20568">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="391"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="484"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="488"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="146"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU44666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="643" mass="72523" checksum="F6F23234367C8ECB" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C7YUE2</accession>
    <name>C7YUE2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_84891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050109.1">
        <property type="nucleotide sequence ID" value="XM_003050063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YUE2"/>
    <dbReference type="GeneID" id="9665550"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84891"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84891"/>
    <dbReference type="HOGENOM" id="CLU_1525578_0_0_1"/>
    <dbReference type="InParanoid" id="C7YUE2"/>
    <dbReference type="OrthoDB" id="10603788at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU44396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="176" mass="19592" checksum="CC99488BCC6E4E76" modified="2009-10-13" version="1">MSAPARDHPGVQRYWPTYGLARAATELPVWHQFFSRGDHVSLLATIRILQANDCASARTTALACLTIEKAQVAYRPKRTKTRSSLFSQEGLEFQAELGVDQDGDLRQLQQQWSQQHRIGCNGSTPSYNHPLYVLPELSVLGGRRDKEGNPTSHLGTRRKAGPAFSWACYAASVIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7YUS4</accession>
    <name>C7YUS4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cleft lip and palate transmembrane 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_63771</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050569.1">
        <property type="nucleotide sequence ID" value="XM_003050523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YUS4"/>
    <dbReference type="STRING" id="660122.C7YUS4"/>
    <dbReference type="GeneID" id="9665692"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_63771"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_63771"/>
    <dbReference type="eggNOG" id="KOG2489">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019907_2_0_1"/>
    <dbReference type="InParanoid" id="C7YUS4"/>
    <dbReference type="OMA" id="TLWAHFY"/>
    <dbReference type="OrthoDB" id="378564at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF0">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="518"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="618"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU44856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="662" mass="74570" checksum="3C5915D9473A153D" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7YUX3</accession>
    <name>C7YUX3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_101719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050597.1">
        <property type="nucleotide sequence ID" value="XM_003050551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YUX3"/>
    <dbReference type="FunCoup" id="C7YUX3">
        <property type="interactions" value="159"/>
    </dbReference>
    <dbReference type="GeneID" id="9674552"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101719"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101719"/>
    <dbReference type="eggNOG" id="KOG1470">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014001_1_2_1"/>
    <dbReference type="InParanoid" id="C7YUX3"/>
    <dbReference type="OMA" id="DIHARPC"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.525.10:FF:000013">
        <property type="entry name" value="Phosphatidylinositol transfer protein PDR16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="117"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU44884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="351" mass="40280" checksum="2F27B0E04749A64B" modified="2009-10-13" version="1">MASSTENTAAPRKTPIAAPTADTKPAPRPELTDEQKTKYETLLEHARGITEIQCEKQADKEDKSGPITDRERAWLTRECLLRYLRATKWTVDDSAKRLRATLAWRREYGLDDFTPDYISPEQETGKQMIVGFDRQGRPCQYLNPARQNTDTSPRQLHHLFYMVERVTDLMPPGVEMLSLMINFKPSKERKNTSVPVSTAREVLHILQNHYPERLGKALIINVPWIVWGFFKIITPFIDPVTREKLKFNEDMKQYVPPEQLWSLDWGGEMDFEYDHATYWPALNEMCKQRREERFRRWEAAGKEVGESEDYLAGGTDVSVKGVKFGGDVDGVAEKLAETGLESIAEQPTVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7YV45</accession>
    <name>C7YV45_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_48919</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050633.1">
        <property type="nucleotide sequence ID" value="XM_003050587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YV45"/>
    <dbReference type="GeneID" id="9675016"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_48919"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_48919"/>
    <dbReference type="eggNOG" id="ENOG502SITX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006524_12_0_1"/>
    <dbReference type="InParanoid" id="C7YV45"/>
    <dbReference type="OMA" id="HLAWAHY"/>
    <dbReference type="OrthoDB" id="5226580at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="14"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="50"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="522"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="525"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU44920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="580" mass="63409" checksum="38E7373A8E065CD7" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C7YW52</accession>
    <name>C7YW52_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_30392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049825.1">
        <property type="nucleotide sequence ID" value="XM_003049779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YW52"/>
    <dbReference type="GeneID" id="9677400"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_30392"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_30392"/>
    <dbReference type="eggNOG" id="ENOG502S6PB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021422_1_0_1"/>
    <dbReference type="InParanoid" id="C7YW52"/>
    <dbReference type="OMA" id="IFAPRIW"/>
    <dbReference type="OrthoDB" id="5213490at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="576"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU44112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="677" mass="76392" checksum="2D88C9A6DBD0320D" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWI0</accession>
    <name>C7YWI0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_57051</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU43960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049673.1">
        <property type="nucleotide sequence ID" value="XM_003049627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWI0"/>
    <dbReference type="FunCoup" id="C7YWI0">
        <property type="interactions" value="946"/>
    </dbReference>
    <dbReference type="GeneID" id="9674512"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_57051"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_57051"/>
    <dbReference type="eggNOG" id="KOG0759">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_14_1_1"/>
    <dbReference type="InParanoid" id="C7YWI0"/>
    <dbReference type="OMA" id="TTRFGAY"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000107">
        <property type="entry name" value="Mitochondrial dicarboxylate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="28"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="121"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="221"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU43960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="315" mass="34903" checksum="1BC2AC5FE7AA7D81" modified="2009-10-13" version="1">MATAQESVANMSTKAEPVKKEEPTRKKASIRYPFWFGGSASSLAACVTHPLDLVKVRLQMRTGNAPKNMVGTFVQILRHDGPLGLYSGISASLLRQMTYSTVRFGVYEEIKTRLSAGGRDPSFPVLIGLAAGSGFLGGIAGNFADVLNVRMQHDAALPHAERRNYRHAFDGMVRMAREEGPKSMFRGWWPNSTRAMFMTAGQLASYDVSKRLLLKYTPMEDNLKTHFTASFLAGLVAATVTSPIDVIKTRVMSSSHNHGVLHLIGDIYRSDGLMWVFKGWVPSFLRLGPQTICTFVFLEMHRNAYRKVKGLDANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7YX04</accession>
    <name>C7YX04_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_82847</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049456.1">
        <property type="nucleotide sequence ID" value="XM_003049410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YX04"/>
    <dbReference type="STRING" id="660122.C7YX04"/>
    <dbReference type="GeneID" id="9666124"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82847"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82847"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_3_0_1"/>
    <dbReference type="InParanoid" id="C7YX04"/>
    <dbReference type="OMA" id="WTMGGQP"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="7"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU43743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="391" mass="42111" checksum="55526E358E54341C" modified="2009-10-13" version="1">MSVAKPILISGSGLASLLLAQSLRLSKIPFRIFERDESFIFRAQGYRLRLSTEGLDAIESVLDAKTWEHFWDKCGKTGGSGFAAFDAVTGEQTEHVVPEKLVSRGGKVVGIARGDMRKIFAEGCEDHIEWSRNVTGYELTDDGVRAIFSDGTKSIEGSMLIGGEGIYSKVAKQVSGGKLKVYDTGARGIHGQAPTTAFKGLGEGVFRLRDATRPDGAVFIITNVRPSEMDDPNVEFGWTMGGEPGVIRAPNDDYSIVGKQAAEIAKSMSKDWHPRFKPLFDEMNESEAAFWKITCSTPSGVPEWPNEPRVTVIGDAAHSMTPAGGIGANTAVRDSALLGRLLREAGGYKPGVTAAYEKEMRVYASEAVNESYTGASGAFGIKIDEETSPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXJ3</accession>
    <name>C7YXJ3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_45071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049064.1">
        <property type="nucleotide sequence ID" value="XM_003049018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXJ3"/>
    <dbReference type="STRING" id="660122.C7YXJ3"/>
    <dbReference type="GeneID" id="9666368"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45071"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45071"/>
    <dbReference type="eggNOG" id="ENOG502RJPT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024934_2_0_1"/>
    <dbReference type="InParanoid" id="C7YXJ3"/>
    <dbReference type="OMA" id="ERICEYG"/>
    <dbReference type="OrthoDB" id="4937900at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU43351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="388" mass="43713" checksum="70BDE37620F2D77D" modified="2009-10-13" version="1">METNRVRKPRQGHRKSRNGCAVCKKRHIKCDERRPVCGNCEISERECYYVAPRRAKVGSNPYEMELTTSAWLQTAATSRDSESPASPDLHDIESDELFTFEHLKLLYNIQEHMMDWMMVTDSLKPLANGYVTAALETPYLMNQLLALSAMHLSTANPESSAHYTQTASNLRHRALRGFNKALNDTSQGNATSQFFFASLLALHYFAETITAAPNQDFSTTLQHVLEYFRLHRGARVLSDRARSTFVSSSVMGWLVAAVKESKEGSHRPSESCSLLETMLQASDLNEESLQACQGAREALDLVYGWLQGPNGWGVHALLGWSNLIPLRFLSLLEKQTPEALVILAHYAVLMHRFRAFWCLGDVGKRLVNGISGLLATYWVDWLPTIDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXX2</accession>
    <name>C7YXX2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-aminobutyrate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GABA aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-amino-N-butyrate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_45277</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23352"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="2.6.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.19" evidence="3"/>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049124.1">
        <property type="nucleotide sequence ID" value="XM_003049078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXX2"/>
    <dbReference type="FunCoup" id="C7YXX2">
        <property type="interactions" value="290"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YXX2"/>
    <dbReference type="GeneID" id="9666437"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45277"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45277"/>
    <dbReference type="eggNOG" id="KOG1405">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_12_0_1"/>
    <dbReference type="InParanoid" id="C7YXX2"/>
    <dbReference type="OMA" id="HDPEIVP"/>
    <dbReference type="OrthoDB" id="10260828at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034386">
        <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000029">
        <property type="entry name" value="4-aminobutyrate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004631">
        <property type="entry name" value="4NH2But_aminotransferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00699">
        <property type="entry name" value="GABAtrns_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206:SF1">
        <property type="entry name" value="4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU43411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="480" mass="53235" checksum="5B701ED958A31961" modified="2009-10-13" version="1">MPTFIEKPEKATKDEAPFLPDEPAGPTVVTAFPGPKSKEAVRRLDKVFDASAAVLMVDYHKSYGNYIADVDGNVMLDVYAQIASIPVGYNNPTLLKAATSPAMASALINRPALGNFPQNDWASILETGLLKVAPKGMNQVYMALSGADANELAYKAAFIWKRQQERGQRDAGFTQEELDSTMLNHQPGSPNLSIMSFKAAFHGRLFGSLSTTRSKPIHKLDIPAFDWPQCPFPAIRYPLEDHIEENEWEEKRCLEEAEHIIKSYPSKVAAVIVEPIQSEGGDNHASPAFFQGLREITRRHKVLLIADEVQTGVGATGRFWAHEHWGLSDDPDMVTFSKKAQTGGFYFGNPDLRPNKPYRLFNTWMGDPARAILFGAIIDEIERLDLVKNTGTVGDYLYSEIEKLAKKYPGKFGNLRGKGEGTFIAFDNPRRDEFLALAKTHGINLGGCGASSVRLRPMLIFQKHHADILLGVFDKIAKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYY5</accession>
    <name>C7YYY5_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_101319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048793.1">
        <property type="nucleotide sequence ID" value="XM_003048747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYY5"/>
    <dbReference type="STRING" id="660122.C7YYY5"/>
    <dbReference type="GeneID" id="9665640"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101319"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101319"/>
    <dbReference type="eggNOG" id="ENOG502SXJS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1390342_0_0_1"/>
    <dbReference type="InParanoid" id="C7YYY5"/>
    <dbReference type="OMA" id="MRFTYIA"/>
    <dbReference type="OrthoDB" id="5106238at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988807" evidence="2">
        <location>
            <begin position="18"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU43080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="207" mass="19949" checksum="95ED4D291566944E" modified="2009-10-13" version="1">MKYSAATVFAIMALAKAQSVSVPGEDAVSSIIGDVSSRVESIASEVSSRAADASAGASSIAEEISSRVASLSSAATATGASETVTETGTETVTGTATDETETGTATDETETGTETGTETGTETGNTADTAAIASKTSELGDRIASLSSKVADATGSDAASISSEIAAATSEIGALASSATEGNSGAMHTAAIAMGALFGGAAVIVNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z014</accession>
    <name>C7Z014_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_84215</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048603.1">
        <property type="nucleotide sequence ID" value="XM_003048557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z014"/>
    <dbReference type="STRING" id="660122.C7Z014"/>
    <dbReference type="GeneID" id="9667680"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84215"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84215"/>
    <dbReference type="eggNOG" id="KOG0594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005931_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z014"/>
    <dbReference type="OMA" id="QGWHQDI"/>
    <dbReference type="OrthoDB" id="9992527at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF98">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="311"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="637"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="651"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="701"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU42890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1011" mass="113848" checksum="8A941F4494EE62EF" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0I3</accession>
    <name>C7Z0I3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">X-Pro dipeptidyl-peptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_39842</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048098.1">
        <property type="nucleotide sequence ID" value="XM_003048052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0I3"/>
    <dbReference type="GeneID" id="9671907"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_39842"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_39842"/>
    <dbReference type="eggNOG" id="ENOG502SFAI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035441_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z0I3"/>
    <dbReference type="OMA" id="FHEMIPG"/>
    <dbReference type="OrthoDB" id="5959877at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361:SF2">
        <property type="entry name" value="DUF885 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="GLR0591 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU42385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="548" mass="63857" checksum="6F9582753C132568" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0U1</accession>
    <name>C7Z0U1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_40151</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048154.1">
        <property type="nucleotide sequence ID" value="XM_003048108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0U1"/>
    <dbReference type="FunCoup" id="C7Z0U1">
        <property type="interactions" value="141"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z0U1"/>
    <dbReference type="GeneID" id="9671959"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_40151"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_40151"/>
    <dbReference type="eggNOG" id="KOG1612">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046570_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z0U1"/>
    <dbReference type="OMA" id="INKRWHW"/>
    <dbReference type="OrthoDB" id="272245at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="8">
        <location>
            <begin position="35"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU42441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="340" mass="36869" checksum="9BB7E0C597E46097" modified="2009-10-13" version="1">MATQQSLFSPAELAYLHRTLSLRPPIRPDGRTPTQFRPLTAETGVLPGTNGSARVQFADGTEAIVGVKAEIEKTAGGEEDQGEEDRTRGDWIELAVEIPGQRDDDASTVFLAEMLREALLADKEFAKKLRINRRFHWRLYLDVLLISPPLAYPLPLLSLTTHLALLATRLPRLKSEGDEDPMFDDDWEASTFLYPREGAGAAGSRPPITLLVVAVGDNTIFDPAKEELAVAETALAVSVAEVRRVKTEGDMEVDSTDRQLRLLSIRTVDPPSRLTPPGVPHTTNTNGTKKAGDAQTTEGVWKAPLGGTKFGVMDGIIQAVLEKGGVADDVLDGLEGVELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0Y1</accession>
    <name>C7Z0Y1_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_69058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048177.1">
        <property type="nucleotide sequence ID" value="XM_003048131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0Y1"/>
    <dbReference type="STRING" id="660122.C7Z0Y1"/>
    <dbReference type="GeneID" id="9671976"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_69058"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_69058"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_21_4_1"/>
    <dbReference type="InParanoid" id="C7Z0Y1"/>
    <dbReference type="OMA" id="GERIPVM"/>
    <dbReference type="OrthoDB" id="25896at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU42464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="187" mass="21282" checksum="7E18D79704B3A757" modified="2009-10-13" version="1">MDTEVIRILLVGDEKCGKTTFLSRLSAGENVNPIPLLRDIDQPYIFGIKTGTKQYRFEFFDTSSPDNWRLLDPDAIVICFDISQRLTLINMQRYWIDEVKKSFQRFDTLPLIILGLKRDLRSEKDPNGIIYPQEAYQVAQTLRADRYVECSAVTGELLKLAFEDLCKTAVTPTTGSNSQSASTCMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z143</accession>
    <name>C7Z143_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_80108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048013.1">
        <property type="nucleotide sequence ID" value="XM_003047967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z143"/>
    <dbReference type="GeneID" id="9671998"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_80108"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_80108"/>
    <dbReference type="eggNOG" id="ENOG502SDUB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_543000_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z143"/>
    <dbReference type="OrthoDB" id="508139at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="140"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU42300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="502" mass="57143" checksum="41BF752170787A23" modified="2009-10-13" version="1">MVVPKRSASPLEGDVLKSTKKPSSRNSNSTTDSTETPADVPVGIIVSLRLDSKAKRNDPESNQHVDRRDDLADGSEDQPIQENPGTIQGDDDAEFEEEIKALSNLSGLPFLDDFAHLKWLERIDRLAILKRTRIGRCDAMLIRRLQIHHKFWTAMEEPTRQTSELAFELFDRYGRLRKEFREHPVNKGTGVWGRELDGEDILLFESIRIEPGHRRQKIGTKLVNAVLNKARRKTTKFFALAKPRCLVDEFDDEDTEQRVVATEAAEQFFLSIGFRRVGTSGWFAFTDDTSHSSKRLETSDDWNQPRLTQVPQSTVETFDRLRGPDMVDCECVRLLQTDLRLELEDNPGISLDEKENTILHLFALRTWPKSIAYAIDKWPQLKNARNREGHTPLEALQRLLEMSRTTRIEKGKTHVVSDDFRGFSPVQIASLGALEDVNVCDLDKVSKDIISRVFTTPKQEFQRIPGASEIQKTLRLKVNCNWGLSGIRSTMAVYGSSGTEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z166</accession>
    <name>C7Z166_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UDENN FLCN/SMCR8-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_40367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048230.1">
        <property type="nucleotide sequence ID" value="XM_003048184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z166"/>
    <dbReference type="STRING" id="660122.C7Z166"/>
    <dbReference type="GeneID" id="9672008"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_40367"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_40367"/>
    <dbReference type="eggNOG" id="KOG3715">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046465_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z166"/>
    <dbReference type="OMA" id="CDNCAMT"/>
    <dbReference type="OrthoDB" id="5599713at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037521">
        <property type="entry name" value="FLCN/SMCR8_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021713">
        <property type="entry name" value="Folliculin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037520">
        <property type="entry name" value="Folliculin/SMCR8_longin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31441:SF2">
        <property type="entry name" value="FOLLICULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31441">
        <property type="entry name" value="FOLLICULIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11704">
        <property type="entry name" value="Folliculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51834">
        <property type="entry name" value="DENN_FLCN_SMCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN FLCN/SMCR8-type" evidence="2">
        <location>
            <begin position="236"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU42517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="478" mass="50371" checksum="56C5D5F505EEB149" modified="2009-10-13" version="1">MRKTQQLMSSFQLCLAHYCDLHGPTPLMVTEGLPAPCTICCEDGIDSADTRPRSSAHATGPTTHSSAALNDALRNLNLSRSASAPASEHDAQAQRAALLRTSSSGAAATQSAIDTPPDSPRPVPPQHPRRDSSFRRTYDETVTKKQGPCENCAMTLPKQQGGSNNVHFANNARGPTLRTRAPAERVFGAGGQASPPNSQPSSDTDGERDEGPRARMRTTPSVSSRNTSRSSGSAGTGNSSTADRTPFHVHYVDYTSTHDPVLPDSFSLIRASCLRTLSFETLPRAPATATPVSPLSATSPAFVTTQSAGSAVTGGPIFFGDALAGYTTAYIFRIPDVHARGHKRVYAFLALSTHRERLAMKTFAVVSTAFRDLATWIQQLAEAEAERAAEASPIGSNMYGGGYAPPQSAVESAGGPDRGGSSFLTGGSGFTRRMGGGPGASAPKARGLAEIVGRPDIFFDLHSRFVHLLFEVGVTLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1K4</accession>
    <name>C7Z1K4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pentatricopeptide repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_51040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU42019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047732.1">
        <property type="nucleotide sequence ID" value="XM_003047686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1K4"/>
    <dbReference type="STRING" id="660122.C7Z1K4"/>
    <dbReference type="GeneID" id="9671685"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51040"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51040"/>
    <dbReference type="eggNOG" id="ENOG502S1QC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007655_1_1_1"/>
    <dbReference type="InParanoid" id="C7Z1K4"/>
    <dbReference type="OMA" id="ARMFATR"/>
    <dbReference type="OrthoDB" id="5366531at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="863" mass="99181" checksum="18F10B222E777D31" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1M4</accession>
    <name>C7Z1M4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_50976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU41851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047564.1">
        <property type="nucleotide sequence ID" value="XM_003047518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1M4"/>
    <dbReference type="STRING" id="660122.C7Z1M4"/>
    <dbReference type="GeneID" id="9671523"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_50976"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_50976"/>
    <dbReference type="eggNOG" id="ENOG502T0JZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031554_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z1M4"/>
    <dbReference type="OMA" id="SVWGAQM"/>
    <dbReference type="OrthoDB" id="4760831at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052981">
        <property type="entry name" value="Ingression_C2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052">
        <property type="entry name" value="CONSERVED SERINE PROLINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_2G01790)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052:SF3">
        <property type="entry name" value="INGRESSION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="508"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU41851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="681" mass="76751" checksum="A47F4205EA7F74D5" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z223</accession>
    <name>C7Z223_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_50811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU41925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047638.1">
        <property type="nucleotide sequence ID" value="XM_003047592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z223"/>
    <dbReference type="GeneID" id="9671773"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_50811"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_50811"/>
    <dbReference type="eggNOG" id="ENOG502SVP6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148785_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z223"/>
    <dbReference type="OMA" id="SRFTNIG"/>
    <dbReference type="OrthoDB" id="9986861at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU41925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="136" mass="15187" checksum="08B44E440C2BCBE2" modified="2009-10-13" version="1">MASPIHIPVLTISLARHLVGYSITEVLEQQWDPAKVPTSTTSRFANIGFDLDVNGANLEDLRKVLAERQWSGIIVGWCTRGHVEFTELFESVVAICVDYIVEKRQGNASAKEPKLIFCRCADDVVNATLRNFPLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z229</accession>
    <name>C7Z229_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_86004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU41928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047641.1">
        <property type="nucleotide sequence ID" value="XM_003047595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z229"/>
    <dbReference type="STRING" id="660122.C7Z229"/>
    <dbReference type="GeneID" id="9671776"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86004"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86004"/>
    <dbReference type="eggNOG" id="ENOG502T5II">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128319_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z229"/>
    <dbReference type="OMA" id="FAQMAND"/>
    <dbReference type="OrthoDB" id="5330139at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU41928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="172" mass="19474" checksum="6B351422F73A65C4" modified="2009-10-13" version="1">MSSRLAAQIHRPLRAVSVWTSKPIYQRRRFHERKADLVTLDANGSLETRKLDVITGDPHEAYVIVDRNVGFAMRSAIMKQTESSLATNAERVPLVFHHHSRHFAHHTAPYPRIILEHDLPHQNPGATSPATLWLWGATHSITLDGTSDAKFEEACRESHERLEGAAKLLKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z2B4</accession>
    <name>C7Z2B4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_86093</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU42143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047856.1">
        <property type="nucleotide sequence ID" value="XM_003047810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z2B4"/>
    <dbReference type="GeneID" id="9671641"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86093"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86093"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1082170_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z2B4"/>
    <dbReference type="OrthoDB" id="72788at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF4">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="6">
        <location>
            <begin position="142"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU42143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="257" mass="27910" checksum="FF756FF5F94C86AB" modified="2009-10-13" version="1">MAAKESPCPPTSVIDNVGARFPLLHSSPTTTIRHRNGVKEDTETPKLFTPLTIRGVTFQSRLFSAPLCRCSAKDGYATDWHLTQLGGSTQRGPGLALDIGLREDDQIELLKTSLTAGTENIGIQLSQAGRKSSTMVSFLHKNPKEMILNQIEVVKVAFADATKRAVKAGLDVVEIHAAHGHLIYQFLSPISNQSKDRYGGSWENRLPEGWTVADSCKLAPILAERDADFLEVSSGETPKAAKYQMIVPAIGRISTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z303</accession>
    <name>C7Z303_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_53988</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047461.1">
        <property type="nucleotide sequence ID" value="XM_003047415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z303"/>
    <dbReference type="FunCoup" id="C7Z303">
        <property type="interactions" value="412"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z303"/>
    <dbReference type="GeneID" id="9676202"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_53988"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_53988"/>
    <dbReference type="eggNOG" id="KOG2495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019845_6_2_1"/>
    <dbReference type="InParanoid" id="C7Z303"/>
    <dbReference type="OMA" id="WKIGAPR"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="2"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU41748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="387" mass="43407" checksum="D73AF4946101E2E9" modified="2009-10-13" version="1">MKDIVILGAGLAAAPLIRQIMLKSVLRQDNLRLTVVAPNTHFHWPIAMPRVILPDHWSEHKAMFELYPFFKDYPPERFEFVLGAASSMDLEGKHITVALNRGGVYTVHYDTLVIATGSSAQDHVPWTVLGTTEETKEKLHALWDDIRRAETIVIAGGGPTGTETAGEIAYEYRDEKEVYFIYDDALPLGPSTLDSVRKQVIKELSKLKVNMLPKTRVTEVTKDGKDTILQLRRADGSFQTLRTQAYIPATGTKPNTAFAPNEILDNRGFIKQTGYLQVEGHSDIFVLGDAGNLESNRAMYADSQCLHLIKNLPIYLSGGKMTPYKKKQKEMIAITLGRKRATGQLGNIKILSLLLWYAKGRWMGTDYAYDLAAGRRSLSTVLEKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z382</accession>
    <name>C7Z382_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_87859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047501.1">
        <property type="nucleotide sequence ID" value="XM_003047455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z382"/>
    <dbReference type="GeneID" id="9676242"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87859"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87859"/>
    <dbReference type="eggNOG" id="KOG1546">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016732_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z382"/>
    <dbReference type="OMA" id="PLYMAIF"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="2">
        <location>
            <begin position="48"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU41788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="723" mass="79847" checksum="D50D85963E2EB4EC" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z3I9</accession>
    <name>C7Z3I9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_28119</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047031.1">
        <property type="nucleotide sequence ID" value="XM_003046985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z3I9"/>
    <dbReference type="STRING" id="660122.C7Z3I9"/>
    <dbReference type="GeneID" id="9675777"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_28119"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_28119"/>
    <dbReference type="eggNOG" id="KOG4169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_13_0_1"/>
    <dbReference type="InParanoid" id="C7Z3I9"/>
    <dbReference type="OMA" id="VNIRINC"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU41318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="22794" checksum="D9C05842655E36C6" modified="2009-10-13" version="1" fragment="single">SNPVAFITGGCSGIGLALSRHLLGKGWHVAMIDLQPPPGQFHQHGDSTLFLKADVSSWEQQVDAFAQAFEWKGRLDMAALNAGIDDRDDIFNSVDPATLPRKPNMSPFDIDLLGVYYGIKLFAHYASRNPNPGGKIIMTSSAAGLYGSAGMPQYAAAKAGVISLARSLARPAAQHNITINAICPMMVNTPLPPRAFLEAFPKEHITPMEIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z3P9</accession>
    <name>C7Z3P9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_83326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046887.1">
        <property type="nucleotide sequence ID" value="XM_003046841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z3P9"/>
    <dbReference type="STRING" id="660122.C7Z3P9"/>
    <dbReference type="GeneID" id="9678694"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83326"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83326"/>
    <dbReference type="eggNOG" id="ENOG502TH6X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_824095_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z3P9"/>
    <dbReference type="OrthoDB" id="5430065at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU41174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="35985" checksum="222BA95B31E2E011" modified="2009-10-13" version="1">MFVLFFFLLGLAVGQDFAITAAPTFLFKRQQRITDCDGPTHALWTCPNGECYWGDDGFVGCCSLSSCAPRTRCIEYDDLEDDICDHNTGGCVVCSKSESPLCVFLTNPAMKEYGYYCDTARRTGSSSFEYDLPAGAVIRTIKDTQEAPITTETDSEDTTTTDDFTIEGGSESETETATDATATEATATEATATGATTTEADPTSSGGTTDPTATDTAVADASELTETKGKLRSAIAAAAALGAIVGTLILLAIAFIWYRKRSKRQEHPQPIAQPMVHSQPSSVPGYSHQYYETVSNPPSASVSPPNTSFGGSAVAPSPTSRADEQMPHIPELGRYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z3X4</accession>
    <name>C7Z3X4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="10">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_62562</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="10"/>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046931.1">
        <property type="nucleotide sequence ID" value="XM_003046885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z3X4"/>
    <dbReference type="FunCoup" id="C7Z3X4">
        <property type="interactions" value="413"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z3X4"/>
    <dbReference type="GeneID" id="9675502"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_62562"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_62562"/>
    <dbReference type="eggNOG" id="KOG3964">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030471_1_1_1"/>
    <dbReference type="InParanoid" id="C7Z3X4"/>
    <dbReference type="OMA" id="HKCLAQC"/>
    <dbReference type="OrthoDB" id="10250191at2759"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09135">
        <property type="entry name" value="PLDc_PGS1_euk_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09137">
        <property type="entry name" value="PLDc_PGS1_euk_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000850">
        <property type="entry name" value="Phospholipase_D_PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="11">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU41218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="493" mass="54924" checksum="642C6AF582AEEA35" modified="2009-10-13" version="1">MSAGAPAPAPASSPAGGVGALAPFVNELDRLAPSFDVRGDQIQIIRTPTEFYETLKDRIRKAQRRIFLSTLYIGKSERELIETLQEALRENPEVKLSILTDCLRGTREAPNPSCASLLAPLVEEFGADRVEIRMYHTPNLTGLRKEYIPKRINEGWGLQHMKLYGVDDEIIMSGANLSTDYFTNRQDRYHLFSSKEVTDHFWKIHSGATSFSFLVQPSEEPAGFTLSWPTTNSAPSPLEKPQAFIKRTTSTLQALIHPTSKPTQDISDTRVYMLSQMSQVMKPDTSTELPIITHILKTLASPAYRDSSWTFTAGYFNPAPSLTKLLLNTASTSNTVITAAPEANGFYKSKGVSGLLPDAYTLLARRFVHRVHHEGRDEDITLKEWRHGMVGQPGGWTYHAKGLWVTMPGDKHPAMSIIGSSNYTKRSYSHDLEAGALIVTRDEGLKARLADEQLWLQEHATKATRDDFAKNERRVGLKVRVAMWIVSLVGGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z467</accession>
    <name>C7Z467_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_45958</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047141.1">
        <property type="nucleotide sequence ID" value="XM_003047095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z467"/>
    <dbReference type="GeneID" id="9675626"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45958"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45958"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_0_1"/>
    <dbReference type="InParanoid" id="C7Z467"/>
    <dbReference type="OMA" id="WKRTSWI"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF12">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
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            <end position="102"/>
        </location>
    </feature>
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            <end position="137"/>
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            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
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            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
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        <location>
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            <end position="245"/>
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    </feature>
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        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
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        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
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        <location>
            <begin position="408"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
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        <location>
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            <end position="538"/>
        </location>
    </feature>
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        <location>
            <begin position="80"/>
            <end position="542"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
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    <sequence length="584" mass="63977" checksum="D43871B21C67F8D3" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
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        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="45"/>
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        <location>
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            <end position="855"/>
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    </feature>
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            <end position="332"/>
        </location>
    </feature>
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        <location>
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    </feature>
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    </feature>
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            <begin position="2545"/>
            <end position="2562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF21678"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF25038"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEU40949.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3214" mass="357806" checksum="35230DA4C86A6A5B" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4V2</accession>
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        </recommendedName>
    </protein>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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            <taxon>Fusarium</taxon>
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            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
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            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
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        </reaction>
    </comment>
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        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF38">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013039583" description="Mannan endo-1,6-alpha-mannosidase" evidence="12">
        <location>
            <begin position="16"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU40986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="468" mass="51869" checksum="07548E3F6FC964F5" modified="2009-10-13" version="1">MKLWALASLASLAVAANKTAPSSLDIKDPDSIKDVAASIAYDAMTYYSGNTSTVPKDLGDLQDPYYWWVAGALWGVMLDYYHFTGDPSYNDVIIQALLAPTNLGPDHDYMPPEHADEEGNDDLFFWGSAVLSAAERNFPQPNKTLPSWLDISANVFNELVGRWNMSACNGGLLWQIFPENPNGLTYKNSVSNGGFFQLAARLARATGNSTYLDWANKVWDWSWEVGFIDKRNYHVYDGASVLDNCEKTTYHSFTYTSGIYLYGAAVLANYTGKPEWEERSKRLLDGTDWFFSPFDNTTDIMYEAACETVNTCNWDMSTFKGYLSRFMYQSIQMQPSLKDHVERFLVPSAQAAAKTCTGGKSGRECGMRWWVGGFDGNPGLGQQMCALEIVQGLLLDDLPVPLQGDQIKVVRDTDWNKETKTKATPTPSPTNTEKPKPTESDDAASLARADLVLASFSIGTVLLLLGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z532</accession>
    <name>C7Z532_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_76730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU41029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046742.1">
        <property type="nucleotide sequence ID" value="XM_003046696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z532"/>
    <dbReference type="GeneID" id="9678270"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76730"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76730"/>
    <dbReference type="eggNOG" id="ENOG502QWAB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_489228_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z532"/>
    <dbReference type="OMA" id="RETCTIF"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU41029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="557" mass="63234" checksum="1A10532A1AF77EEA" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z681</accession>
    <name>C7Z681_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_33514</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046365.1">
        <property type="nucleotide sequence ID" value="XM_003046319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z681"/>
    <dbReference type="GeneID" id="9667925"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_33514"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_33514"/>
    <dbReference type="eggNOG" id="ENOG502S3FG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007607_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z681"/>
    <dbReference type="OMA" id="WLPICEK"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF2">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="654"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU40652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="747" mass="81780" checksum="8C659EA9FD97E60C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z713</accession>
    <name>C7Z713_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL11m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_76275</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045937.1">
        <property type="nucleotide sequence ID" value="XM_003045891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z713"/>
    <dbReference type="FunCoup" id="C7Z713">
        <property type="interactions" value="660"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z713"/>
    <dbReference type="GeneID" id="9668214"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76275"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76275"/>
    <dbReference type="eggNOG" id="KOG3257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074237_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z713"/>
    <dbReference type="OMA" id="CKQFNAK"/>
    <dbReference type="OrthoDB" id="1091498at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000005">
        <property type="entry name" value="Mitochondrial 54S ribosomal protein YmL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000004">
        <property type="entry name" value="Mitochondrial 54S ribosomal protein YmL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_uL11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="10">
        <location>
            <begin position="14"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="9">
        <location>
            <begin position="77"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU40224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="155" mass="16392" checksum="BCE2D3972CD20434" modified="2009-10-13" version="1">MSKGRAAGGVDQIVKLIVGAGQASPSPPVGPALGSKGVKSMDFCKEFNARTAHITTGTPMPCRVVVRPDRSFTFDVRTPHTSWLLLNAADAPTKKGSRKGASNPGHETVGSISLKHVYEIAKIKQTELRLSGLSLEGLCRSIIYQAKSIGINVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7L3</accession>
    <name>C7Z7L3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MoaB/Mog domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_32515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046033.1">
        <property type="nucleotide sequence ID" value="XM_003045987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7L3"/>
    <dbReference type="FunCoup" id="C7Z7L3">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z7L3"/>
    <dbReference type="GeneID" id="9668393"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_32515"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_32515"/>
    <dbReference type="eggNOG" id="KOG2644">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030805_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z7L3"/>
    <dbReference type="OMA" id="MARMPRG"/>
    <dbReference type="OrthoDB" id="448496at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047884">
        <property type="term" value="F:FAD diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042726">
        <property type="term" value="P:flavin-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056596">
        <property type="entry name" value="FLAD1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675:SF1">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24102">
        <property type="entry name" value="FLAD1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="2">
        <location>
            <begin position="18"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU40320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="307" mass="33873" checksum="F686193A8319546E" modified="2009-10-13" version="1">MAPISADERNARTIQTAACLIIGDEVLGGKTVDTNSAYFAKWCFGLGISLKRIEVIEDDESEIMEAVRRMSDRYDFIVTSGGIGPTHDDITYQSIAKAFNLPLKLHQETFEKMKLLSKAHPNQPNFDWNVDSPARKAKLRMAELPTDESRDLKKQALFPHEDMWVPVAVVNGNVHILPGIPKLFQKLLEGLKPYILPRLVDPEGTGTHRILFSTPLPESGVADFLTTLAAKVEPKGIKVGSYPRWGKKHNTVTLVGRDQDYLESLVAEVEAGIKGLRITAEGENSDEESAKATGDATKDTAEPPKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z813</accession>
    <name>C7Z813_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_79628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045634.1">
        <property type="nucleotide sequence ID" value="XM_003045588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z813"/>
    <dbReference type="STRING" id="660122.C7Z813"/>
    <dbReference type="GeneID" id="9672400"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79628"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79628"/>
    <dbReference type="eggNOG" id="ENOG502RJ7S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1138076_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z813"/>
    <dbReference type="OMA" id="MTVFQHE"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU39921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="27932" checksum="BB76A5773C413D6A" modified="2009-10-13" version="1">MNSRSPSTLKSPCPNHSKTRKISSVYWPELKRILENDPSRFYDLDLECLCFERMSIFEHEHVRDPAMDHYTHGAHVLPCGHIFGEKCLVPCRQALGYHPHCYHDLNSLPMPQSLEEIRQFPYFRENVLISNKCGDCIMMDEVRNLSSMAQNHLPPMDLREGEYVGVSISSPDTMWAPSTDPRKADPIIRTIPSSGVLERLCELSRRSLSENWEGVWRSVDFRELEYRLHVFRVTGYPMYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8K3</accession>
    <name>C7Z8K3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TPR repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_43543</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003045047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8K3"/>
    <dbReference type="FunCoup" id="C7Z8K3">
        <property type="interactions" value="1193"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z8K3"/>
    <dbReference type="GeneID" id="9673517"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_43543"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_43543"/>
    <dbReference type="eggNOG" id="KOG1128">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004905_0_1_1"/>
    <dbReference type="InParanoid" id="C7Z8K3"/>
    <dbReference type="OMA" id="NNRYARA"/>
    <dbReference type="OrthoDB" id="1936594at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044244">
        <property type="entry name" value="TTC27/Emw1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="660"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="457"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="593"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="731"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="479"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="610"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU39380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="994" mass="108242" checksum="84D6189BC76FFA16" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9Q6</accession>
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        <recommendedName>
            <fullName evidence="4">Mitochondrial-processing peptidase subunit alpha</fullName>
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        <alternativeName>
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        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Inactive zinc metalloprotease alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Matrix processing peptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_94534</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
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    </reference>
    <comment type="function">
        <text evidence="1">Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.</text>
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        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase M16 family.</text>
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        <property type="protein sequence ID" value="EEU39142.1"/>
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        <property type="nucleotide sequence ID" value="XM_003044809.1"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0017087">
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial processing peptidase, alpha subunit"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
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        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF49">
        <property type="entry name" value="MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="12">
        <location>
            <begin position="61"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="13">
        <location>
            <begin position="214"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="258"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00016741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00083075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU39142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="577" mass="62784" checksum="E337B1B173DCCE22" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9W3</accession>
    <name>C7Z9W3_FUSV7</name>
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        <recommendedName>
            <fullName evidence="14">SP-RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_62176</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIAS family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044883.1">
        <property type="nucleotide sequence ID" value="XM_003044837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9W3"/>
    <dbReference type="STRING" id="660122.C7Z9W3"/>
    <dbReference type="GeneID" id="9672240"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_62176"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_62176"/>
    <dbReference type="eggNOG" id="KOG2169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020537_1_1_1"/>
    <dbReference type="InParanoid" id="C7Z9W3"/>
    <dbReference type="OMA" id="IEPNGDW"/>
    <dbReference type="OrthoDB" id="28127at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16792">
        <property type="entry name" value="SP-RING_Siz-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.780">
        <property type="entry name" value="PINIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023321">
        <property type="entry name" value="PINIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038654">
        <property type="entry name" value="PINIT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031141">
        <property type="entry name" value="SIZ1/2_SP-RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14324">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51466">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PINIT" evidence="11">
        <location>
            <begin position="8"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="SP-RING-type" evidence="10">
        <location>
            <begin position="183"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="277"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="365"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="335"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU39170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="44179" checksum="44A6C8FB9C2C65EE" modified="2009-10-13" version="1">MQSVSFSSSAPGLSNGHRSTAGFGGSQTMALSFKSSPFYKIEATIGEVRACDAMSQHRNTVSIPIKLNDHPSLQNCVDDTSYRVMVFCAGDSTGMQDIAFPHQSELKVNGGEIKANLRGLKNKPGSTRPVDITKALRLRPHYTNNVEFTYALTNKVNELVTRISTGRRIPIDMVKKELNEKAQDPDVVATSQVLSLKCPLSYMRLSLPCRGLSCSHIQCFDATSYLQLQEQGPQWQCPICSKAAPFDQLAVDEYVKDILTRTSKSLESVTIEPDGEWHLKNSDESLGLSNGDSSYHDDYDDDDDVLISEVNPIGHRRLETPKTTTPSIGTPVTAGRDGSSSGPRGTSSISGKRPIAAIIDLTLSDDDDEPAVQPPPKRQNTATNGFYGSNNLANNLALPPNGPSGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9Y8</accession>
    <name>C7Z9Y8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">intramembrane prenyl-peptidase Rce1</fullName>
            <ecNumber evidence="10">3.4.26.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_44179</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic sidechains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.26.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase U48 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.26.1" evidence="10"/>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045297.1">
        <property type="nucleotide sequence ID" value="XM_003045251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9Y8"/>
    <dbReference type="FunCoup" id="C7Z9Y8">
        <property type="interactions" value="297"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z9Y8"/>
    <dbReference type="MEROPS" id="G05.002"/>
    <dbReference type="GeneID" id="9672078"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_44179"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_44179"/>
    <dbReference type="eggNOG" id="KOG4130">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049909_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z9Y8"/>
    <dbReference type="OMA" id="HSFCNWC"/>
    <dbReference type="OrthoDB" id="271604at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039731">
        <property type="entry name" value="Rce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046:SF0">
        <property type="entry name" value="CAAX PRENYL PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046">
        <property type="entry name" value="PROTEASE U48 CAAX PRENYL PROTEASE RCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="12">
        <location>
            <begin position="137"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU39584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="300" mass="33417" checksum="DA09D37227EB2378" modified="2009-10-13" version="1">MSTSISAGFAPPHAVALLVVYCLVYVIPLYFSAATRPSPTRSRDAPEAIRARIFVVSLSTAICSLVTLYLLSSHAAIAIPNPLHFMGYWPVGLVDAARALWLTALLFAGPLYESLFVDGAARQWLHLQPLRDLWTDWPTWRNMVAGPITEECLFRSAGVPLLLRSGASLTGTIFLSPLVFGLAHLHHFYEFRITHPHTPLPVAILRSLFQLTYTTLFGAYATFLFLRTGSLLAVVLIHAFCNCMGLPRFWGQVDPYWLAEDDPARKRYTAVYYVLLVAGLVAWLQNLYSLTETPMALAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZA62</accession>
    <name>C7ZA62_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_81988</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045335.1">
        <property type="nucleotide sequence ID" value="XM_003045289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZA62"/>
    <dbReference type="STRING" id="660122.C7ZA62"/>
    <dbReference type="GeneID" id="9672290"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_81988"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_81988"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009291_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZA62"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="9">
        <location>
            <begin position="657"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="440"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="440"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU39622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1091" mass="120191" checksum="1985DAE10FCD9B24" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAU6</accession>
    <name>C7ZAU6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_82987</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044480.1">
        <property type="nucleotide sequence ID" value="XM_003044434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAU6"/>
    <dbReference type="STRING" id="660122.C7ZAU6"/>
    <dbReference type="GeneID" id="9672782"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82987"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82987"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_821571_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZAU6"/>
    <dbReference type="OMA" id="YHEDAHW"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="155"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="191"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="285"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU38767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="37228" checksum="E083202AB9A8B6B8" modified="2009-10-13" version="1">MPLETLPVELIESIAAKVTSGAGLNALSRTNRHFHQILDRRLYACRSNDKALFFSINKGYSSVLEKAIRGGADLNSLYEWAPGARFTTPLAFAAGTGHVEIVKLLLKHGADPNPVRWEEIRHTPLSVAAGKRHYETAKILIDAGADVHTTFGEPCGSLALHAAVGYYDEDDDLVRLLLENGALDNSPQEYRGTAALEEALTYGRVSTVKLLLQAGANPVFRGSDDWTPVMLAIFGGSEELAFLFLEMGADLEQTCNKGRGLVWYAVWYSCPNVLRYVLERGCSANDHAALRIAFENEEQDIIELLLERGASLEEAGLDESKYRHLISSPRVDHQDAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBC6</accession>
    <name>C7ZBC6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alkaline phytoceramidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_62486</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044408.1">
        <property type="nucleotide sequence ID" value="XM_003044362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBC6"/>
    <dbReference type="FunCoup" id="C7ZBC6">
        <property type="interactions" value="608"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZBC6"/>
    <dbReference type="GeneID" id="9672711"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_62486"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_62486"/>
    <dbReference type="eggNOG" id="KOG2329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063293_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZBC6"/>
    <dbReference type="OMA" id="YVITRYI"/>
    <dbReference type="OrthoDB" id="187171at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187:SF1">
        <property type="entry name" value="ALKALINE PHYTOCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU38695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="30243" checksum="2FBF63324B64C5D2" modified="2009-10-13" version="1">MATPFWGPQTSYLNFCEEDYVVTRYIAEFVNTLSSLTFVAYGIYGLSRSSKSPTVPRWISYCGLIGVGICSAGYHMTMKYHTQMSDELSMHLLTTPLMYRLLTFKASPQKTKWIGIILGSLFTIVMVTHMVMDEFLLHATTFGLGVYIIATRNLKLIPQQVPDPEVRRAVRNVALLGGGFFLLGYIVWLIDDWACHHLIDARRSVGIPVAFLLELHGWWHVFTAIGGYIGVAIVDLVTSGEVTEDPIDSFAWPIPFAARLVTGPTKSAKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBD5</accession>
    <name>C7ZBD5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pleckstrin homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_5366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044413.1">
        <property type="nucleotide sequence ID" value="XM_003044367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBD5"/>
    <dbReference type="STRING" id="660122.C7ZBD5"/>
    <dbReference type="GeneID" id="9670730"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_5366"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_5366"/>
    <dbReference type="eggNOG" id="ENOG502QUAB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028348_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZBD5"/>
    <dbReference type="OMA" id="EANIRYT"/>
    <dbReference type="OrthoDB" id="5865767at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283:SF1">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pleckstrin homology" evidence="2">
        <location>
            <begin position="65"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU38700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="355" mass="40884" checksum="3152E2F6EED00AEA" modified="2009-10-13" version="1" fragment="single">DSSASSERKIPSGHASHTQRLPPVDEDLFYQRLIQSQPRQPPGYEESVALPHDTLPEYHCDIDLEGVFMRKMEITNTTQRAEDRQWRMVYVSLHGTALNIYGVKKSWQWGRTADDGPSVDPDNPPWIDQGKLLKSYSLQYAESGIASDYKKRRYVIRLRVETDQFLISCCELSTFVKWLDWLNAAMNVAAPIEDRDFPFDYSVPRLERISLFHGRERAPAFDRDLGSELDFRRSSTTTGDVSNGSETLISNPPIVGISLSRRWDSFGPQYSDDSINPVTGKWFPQCRWSSAHDMLYAKLCYSNLLFKSPRKSSYVISSGKKWFVDWSTGRMVRVLPPTYEEIDYIGPWQVVRTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZC89</accession>
    <name>C7ZC89_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C6 zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_34681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698918">
        <property type="protein sequence ID" value="EEU38219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043932.1">
        <property type="nucleotide sequence ID" value="XM_003043886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZC89"/>
    <dbReference type="GeneID" id="9670366"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_34681"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_34681"/>
    <dbReference type="eggNOG" id="ENOG502SQ5T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024934_0_1_1"/>
    <dbReference type="InParanoid" id="C7ZC89"/>
    <dbReference type="OMA" id="PPHELWA"/>
    <dbReference type="OrthoDB" id="5295362at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="44188" checksum="C7A078B8568DA41B" modified="2009-10-13" version="1">MSSRRTHTKSRTGCINCKRRKVKVYLMLTTHSVMKLVLHASIAKDMAFPVAYPSIFVNLSHPSPSDQMAPFPPQELWARDCELMHHYCTVTSSTLSIREDMIHVWNVAIPRLGYQSPFVMHGILAIAAAQKAYLIPSSRRIYLPLADYHQTLGSEGYRHQLQTFDLSNWMPVFGFASVVVLHMLTLPTRMENHTLESPLTNLLELASLLRGIKTTLQPIISRVVRTEFAPVVYGVWLLESDEKSEPCPSLDNSLLPTDTWDALKRLRDFQEADIPSGGVSHYTHAVGQLEISAKLFAFAGLYAEAGASLFWLYTIDDSIFIDLDAQRPHALLLFAHFLVHMAALERSFWYVRGWARQTMVKIEEGLIGQPKFQELLQWPKARIAEALALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZC98</accession>
    <name>C7ZC98_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_91437</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698918">
        <property type="protein sequence ID" value="EEU38222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043935.1">
        <property type="nucleotide sequence ID" value="XM_003043889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZC98"/>
    <dbReference type="STRING" id="660122.C7ZC98"/>
    <dbReference type="GeneID" id="9670372"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_91437"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_91437"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_2_1"/>
    <dbReference type="InParanoid" id="C7ZC98"/>
    <dbReference type="OMA" id="LTGWDQY"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="10"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU38222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="332" mass="35907" checksum="9D5F963B49EDB737" modified="2009-10-13" version="1">MSLKFNVFRGSPEGKIFSSSVERDLQPHEVFIETTHSGVCGTDKLYQPSGIALGHEGIGIVREVGSSVNSVKVGQRVGFGYTHEICGSCDNCCRDLDQYCRERKIYGFADTDNGSFSYGAVWDAKCVVPIPDGYDSVDAAPLMCAGSTVWTVLTKYGARCDDRVAVMGIGGLGHLAIKIAAAMGCQVVVLSSSESKREEAMEYGAAEYHVFKSGDEAPADFKPVKHLLLCGSANVDYASLVPIVDTDGIIYPLTASLEATQVPLTQFSIKGIRIQGSLVGSRDSTRKLLEFAARKNIKPTIMTYPLNEEGIESALHDLKDGKVRYRAVLVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCT7</accession>
    <name>C7ZCT7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_5758</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698919">
        <property type="protein sequence ID" value="EEU38100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043813.1">
        <property type="nucleotide sequence ID" value="XM_003043767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCT7"/>
    <dbReference type="FunCoup" id="C7ZCT7">
        <property type="interactions" value="176"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZCT7"/>
    <dbReference type="GeneID" id="9669903"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_5758"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_5758"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_1"/>
    <dbReference type="InParanoid" id="C7ZCT7"/>
    <dbReference type="OMA" id="EPNLACG"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000721">
        <property type="term" value="F:(R,R)-butanediol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034079">
        <property type="term" value="P:butanediol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08233">
        <property type="entry name" value="butanediol_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF23">
        <property type="entry name" value="(R,R)-BUTANEDIOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="10"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU38100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="367" mass="38659" checksum="45B839ACF045975C" modified="2009-10-13" version="1" fragment="single">VTGLQYYGKGDIRLEQITSLPCGPDEVRLKVAYCGICGSDIHEFLGGPIFPPQKGETNKYTGVSLPITMGHEFSGTVIEVGSQVNDITIGQGVAVNPAWDHRHYGADPCGPCKRGRFNTCDDMTTYGLGAPGGGFCEEVVVKAMNCIPLPDGVSLKVAALSEPLSVAHHCIDISGFKPGQTALICGAGPIGLALAAILRVKKASKIIMSEISQSRIAQAPKFGADAVINPLDKGNDGGHPQPDPVLTTVAHLTEDGVDVAFDATGLQSTLDLCIAATRAGGVIFNVAIHERPLQINLNDLVKKEKKLMGGICYQNSDFEAVLQILAEGRLNAEDMITSVVPLSNVVNGGFGELINNKSAHVKILVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDH2</accession>
    <name>C7ZDH2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Beta-xylosidase C-terminal Concanavalin A-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_54713</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043615.1">
        <property type="nucleotide sequence ID" value="XM_003043569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZDH2"/>
    <dbReference type="GeneID" id="9669716"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_54713"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_54713"/>
    <dbReference type="eggNOG" id="ENOG502QQH8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016508_2_0_1"/>
    <dbReference type="InParanoid" id="C7ZDH2"/>
    <dbReference type="OMA" id="QQDDRVW"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18617">
        <property type="entry name" value="GH43_XynB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF16">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="5">
        <location>
            <begin position="351"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU37902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="545" mass="61194" checksum="C2A85D13E98F9037" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZE20</accession>
    <name>C7ZE20_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_88288</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043542.1">
        <property type="nucleotide sequence ID" value="XM_003043496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZE20"/>
    <dbReference type="STRING" id="660122.C7ZE20"/>
    <dbReference type="GeneID" id="9669858"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88288"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88288"/>
    <dbReference type="eggNOG" id="ENOG502QUV4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_4_2_1"/>
    <dbReference type="InParanoid" id="C7ZE20"/>
    <dbReference type="OMA" id="VAQGMTC"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002987035" description="FAD-binding PCMH-type domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="191"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU37829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="654" mass="71712" checksum="82BDC9901F1A7A56" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEE5</accession>
    <name>C7ZEE5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_87425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698921">
        <property type="protein sequence ID" value="EEU37660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043373.1">
        <property type="nucleotide sequence ID" value="XM_003043327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEE5"/>
    <dbReference type="FunCoup" id="C7ZEE5">
        <property type="interactions" value="73"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZEE5"/>
    <dbReference type="GeneID" id="9669258"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87425"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87425"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_1"/>
    <dbReference type="InParanoid" id="C7ZEE5"/>
    <dbReference type="OMA" id="DSVFEMK"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08267">
        <property type="entry name" value="MDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="19"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="347" mass="36225" checksum="6E341E70FD15F381" modified="2009-10-13" version="1">MDASDIPTTMQAWTFSTSGAPEQVLSFNPSSPMPPKPKGSQVLVRISHAALSSAGKTLMMVVPSALRKNAIPELDFSGCVVLAGPDVAPRLGPGTPVFGTVSKYATAVSGHGTLAEYLLIDSDCIAIKPTNMTFAEAACLSVLGQVAMGMIQKAQVKKGDRILINGGSGAVGTAAIQLAKHLGAHVVGVCSGSKADIVKSVGADEVVDYRQVKSVSGFLTETYGKAPFDAILDTVGSQELFIKSPRYLKPNGIVVNVGEGNGETGQLSFILQALRNTHQPSFLGGVPRKYITFSAPLTGANAERLASLAEDGKMRVFIDSSFHFKDVLKASPPSISTLNPLTLQPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEQ4</accession>
    <name>C7ZEQ4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ABC transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_51597</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043173.1">
        <property type="nucleotide sequence ID" value="XM_003043127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEQ4"/>
    <dbReference type="GeneID" id="9665278"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51597"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51597"/>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_27_1_1"/>
    <dbReference type="InParanoid" id="C7ZEQ4"/>
    <dbReference type="OMA" id="SALCITT"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="165"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="554"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="591"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="663"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="692"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="786"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="266"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="555"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="886"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="500"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU37460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1131" mass="123129" checksum="89BA84C4A98CA67A" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHV2</accession>
    <name>C7ZHV2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucan endo-1,3-alpha-glucosidase agn1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_106486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698929">
        <property type="protein sequence ID" value="EEU36347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042060.1">
        <property type="nucleotide sequence ID" value="XM_003042014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHV2"/>
    <dbReference type="GeneID" id="9674396"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_106486"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_106486"/>
    <dbReference type="eggNOG" id="ENOG502QVB5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019141_5_0_1"/>
    <dbReference type="InParanoid" id="C7ZHV2"/>
    <dbReference type="OMA" id="NCFFIPD"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU36347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="576" mass="62502" checksum="B2608B747594908C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZI53</accession>
    <name>C7ZI53_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_86947</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698929">
        <property type="protein sequence ID" value="EEU36383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042096.1">
        <property type="nucleotide sequence ID" value="XM_003042050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZI53"/>
    <dbReference type="GeneID" id="9674366"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86947"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86947"/>
    <dbReference type="HOGENOM" id="CLU_030571_1_1_1"/>
    <dbReference type="InParanoid" id="C7ZI53"/>
    <dbReference type="OMA" id="SHTMHED"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF2">
        <property type="entry name" value="102 KBASES UNSTABLE REGION: FROM 1 TO 119443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="74"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU36383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="367" mass="40140" checksum="5BDD0031E43C940E" modified="2009-10-13" version="1">MALNATTHPIASVRKELELDEPFSLPKSRSQNDIVKVSLAHYGRLATKRGSMCTNPLETPEEQHLRTKESLKVPIFGALIEKEGKSYLWDLGITKDYKYFSGLLKAFLDDVFTPVDLVPTSFAPRLVDEAGKGPIDAIFVSHAHSDHFGDPTAFPGDVPIIYGPGTAAWVQSGAPNVQLPREYLQQHPILEVGTGALGNGKRWQRIGPFDKGWDFFGDGSLWLIQAPGHCLGCQVALCRVTASPDTYILLAGDAAHSQSHYAPVMAGGTYGLLGKIRLPGEPEDVPASHYAYDDSDAAYETISKLIRLNRLGNVMTVAAHEYEMEAVLGMEPGDLSKPLTHWKATGLKEKKARLHLLPQRIPRAGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZI68</accession>
    <name>C7ZI68_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_97439</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698929">
        <property type="protein sequence ID" value="EEU36404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042117.1">
        <property type="nucleotide sequence ID" value="XM_003042071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZI68"/>
    <dbReference type="STRING" id="660122.C7ZI68"/>
    <dbReference type="GeneID" id="9674388"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_97439"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_97439"/>
    <dbReference type="eggNOG" id="KOG1535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_2_1_1"/>
    <dbReference type="InParanoid" id="C7ZI68"/>
    <dbReference type="OMA" id="EYKGQSP"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF100">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G01490)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="78"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU36404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="292" mass="31509" checksum="7C5AF7E301E7346A" modified="2009-10-13" version="1">MSTASWTRLIRFVDDNGNETFGEPIIQDDKEFSDRLAKNDLWAVEYKGTSPVAELTKGEKIHVKTVRELLRPSDVPIIRCIGLNYIKHIKEGGRTPPPYPSVFIKPATCVTGFNDDVPIPKIAQDGTVDYEGELGIVIGKTGKNIPKESALSHIAGYVVSNDVSARAWQRDPKKAGGVPQWCFSKGFDKFAPLGPLLVSPAVVGNASTLNLRTTVNGEERQNSGTGDLLFGVEEIVSFISQGTTLEAGTVVLTGTPSGVAMGMKEPKYLNDGDIVEVSITGLGSVKNKMVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZI91</accession>
    <name>C7ZI91_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_52943</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698930">
        <property type="protein sequence ID" value="EEU36219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041932.1">
        <property type="nucleotide sequence ID" value="XM_003041886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZI91"/>
    <dbReference type="GeneID" id="9674240"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_52943"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_52943"/>
    <dbReference type="eggNOG" id="KOG4157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003527_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZI91"/>
    <dbReference type="OMA" id="WYPSAMI"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF105">
        <property type="entry name" value="COPPER RADICAL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002989297" description="WSC domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="36"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="178"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="289"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="137"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU36219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="917" mass="98899" checksum="9B50C683EC8D8004" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJB5</accession>
    <name>C7ZJB5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="11">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_7634</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="11"/>
    <dbReference type="EMBL" id="GG698933">
        <property type="protein sequence ID" value="EEU35874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041587.1">
        <property type="nucleotide sequence ID" value="XM_003041541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJB5"/>
    <dbReference type="STRING" id="660122.C7ZJB5"/>
    <dbReference type="GeneID" id="9673887"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_7634"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_7634"/>
    <dbReference type="eggNOG" id="ENOG502SING">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031730_4_1_1"/>
    <dbReference type="InParanoid" id="C7ZJB5"/>
    <dbReference type="OMA" id="MWPNENN"/>
    <dbReference type="OrthoDB" id="6038816at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF2">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="12">
        <location>
            <begin position="12"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU35874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="235" mass="25482" checksum="08E62A8B6A9A61C3" modified="2009-10-13" version="1" fragment="single">AILALPNLVSAHYFFPHLYVNDVKSAEYEYVRRSTQGFQPHFGFDILSSNEMRCNTGAQANAGSTKVAEVSAGDTIGFGTNLDGNIQHPGAIQVYMSRATNDDVKSYDGSGDWFKVYELGANFPMQASGENWLIWNKNRVDFTIPAEVPSGEYLVRIEHLALHRPSGTEFYFNCAHIKVTNSGSGQEPTDVVKIPGVYDSNTEGLSPNYSIYNGATSYPMPGPAIFGGSGASSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJC0</accession>
    <name>C7ZJC0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_58738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698933">
        <property type="protein sequence ID" value="EEU35877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041590.1">
        <property type="nucleotide sequence ID" value="XM_003041544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJC0"/>
    <dbReference type="GeneID" id="9673889"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_58738"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_58738"/>
    <dbReference type="eggNOG" id="ENOG502SHDQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026450_2_1_1"/>
    <dbReference type="InParanoid" id="C7ZJC0"/>
    <dbReference type="OMA" id="QHNVMFA"/>
    <dbReference type="OrthoDB" id="671439at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF13">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="485"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU35877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="505" mass="57462" checksum="E4AD4C8EA413AB11" modified="2009-10-13" version="1">MPRQQVYYLHPFGWENDPDEERFPVSTLDYLTACTYNNYALFFRLDDADKSRAVEVLKAGLERTLSQTRHYCGTIEKDPGGGHSFVKKKNSTVRFVVQWLDSPHHDYPSFDDIEKKHFNAVALGNLELWSVPPMTYGEKPEADPNNHPVASAFKANFVKGGLVFHIHHHHYTNDVMGWSGLVHQLAENCFAFANKTPFPDWDPSNLDLARLCKMEPPEHEKIDGPPPQQRHPDHTEAVSLLFHLPKSKAAELKRLATPEDGSWISTYDAFSAFIWRTLTRVRAPVFNPDMSSKIFWSETIDMRRRFHNPKPPARLQQNAMFSAISPTAPVEQPNVGEVISEWPLWQIAAYIRKMTNSVTQESLDKTLEMVATARDKTTMNIRIDAQPPLSILQADHRDASVSRLDFGFATPVTYRHLINRVTTGVIMIYPPRDPSPESDEGPEFSIFYEKRLAQDLISDPAWNEYFEYRGIDAEDATESVNVNVNGKMNGHTSGHASTNDEKNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJX0</accession>
    <name>C7ZJX0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_87963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698936">
        <property type="protein sequence ID" value="EEU35706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041419.1">
        <property type="nucleotide sequence ID" value="XM_003041373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJX0"/>
    <dbReference type="GeneID" id="9676174"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87963"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87963"/>
    <dbReference type="eggNOG" id="ENOG502RMIM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1415532_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZJX0"/>
    <dbReference type="OrthoDB" id="5097148at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="192" mass="21177" checksum="27716505B1D7E81B" modified="2009-10-13" version="1">MADQFDDTLIQRLSKMPPGTRTKEQDAYLNDYCKAASITSDTTGTNASKNSTISLRASSINLSALSSNARIALERSMEGVEDRWNRCKLRAADLARSRASTVVRNRPNATAPSEATSRTTVRASGEPPSPNACMPLDEIARLGTGTAKETDREFRELIDEMVAAQKTLSENDTKQRYFFFSQQKKNKDSGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKF6</accession>
    <name>C7ZKF6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_88794</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698938">
        <property type="protein sequence ID" value="EEU35552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041265.1">
        <property type="nucleotide sequence ID" value="XM_003041219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKF6"/>
    <dbReference type="GeneID" id="9675833"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88794"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88794"/>
    <dbReference type="eggNOG" id="ENOG502QQ9E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004617_2_2_1"/>
    <dbReference type="InParanoid" id="C7ZKF6"/>
    <dbReference type="OMA" id="HGIWVTG"/>
    <dbReference type="OrthoDB" id="2848340at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016518">
        <property type="entry name" value="Alpha-L-fucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054363">
        <property type="entry name" value="GH95_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027414">
        <property type="entry name" value="GH95_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31084">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31084:SF18">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 95 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14498">
        <property type="entry name" value="Glyco_hyd_65N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22124">
        <property type="entry name" value="Glyco_hydro_95_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007663">
        <property type="entry name" value="UCP007663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 95 N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 95 catalytic" evidence="3">
        <location>
            <begin position="267"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU35552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="765" mass="85747" checksum="94C4C4939826AC77" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLM9</accession>
    <name>C7ZLM9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_18017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698946">
        <property type="protein sequence ID" value="EEU35058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040771.1">
        <property type="nucleotide sequence ID" value="XM_003040725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLM9"/>
    <dbReference type="STRING" id="660122.C7ZLM9"/>
    <dbReference type="GeneID" id="9679235"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_18017"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_18017"/>
    <dbReference type="eggNOG" id="ENOG502SHG8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_138_0_1"/>
    <dbReference type="InParanoid" id="C7ZLM9"/>
    <dbReference type="OMA" id="RWERDEM"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF12">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="22"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="296" mass="33357" checksum="AF6ACE6FD9273BA7" modified="2009-10-13" version="1" fragment="single">MRLINTENLHIQSFPGPELPKYAILSHTWTNDEPTLADAQGGLLGTSSKAGCRKVRDFCRLARQDGFYFAWADTCCIDKTSSSELTESINSMFQWYASADICYVYLADLGSDASSDTMASCRWFKRGWTLQELIAPSTLRFYDNEWNLHGSKMEFADQLLQITNIHEAVLRDRASLPMIPVGRRMSWAANRQTTRPEDMAYCLMGIFDVNMPLIYGEGRKAFIRLQEEIMKNDNDLSIFLWRSAPGPKYRGILAEDPSEFACASRLRAGVAGMDSPQSTMTNKGVKIKVALADNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLR4</accession>
    <name>C7ZLR4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,3-beta-glucan synthase</fullName>
            <ecNumber evidence="3">2.4.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,3-beta-D-glucan-UDP glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">FKS1</name>
        <name evidence="14" type="ORF">NECHADRAFT_59665</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-beta-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21476"/>
            <dbReference type="Rhea" id="RHEA-COMP:11146"/>
            <dbReference type="Rhea" id="RHEA-COMP:14303"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.34"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 48 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.34" evidence="3"/>
    <dbReference type="EMBL" id="GG698947">
        <property type="protein sequence ID" value="EEU35034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040747.1">
        <property type="nucleotide sequence ID" value="XM_003040701.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="C7ZLR4">
        <property type="interactions" value="603"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZLR4"/>
    <dbReference type="GeneID" id="9679163"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_59665"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_59665"/>
    <dbReference type="eggNOG" id="KOG0916">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000844_0_1_1"/>
    <dbReference type="InParanoid" id="C7ZLR4"/>
    <dbReference type="OMA" id="AWTDFFI"/>
    <dbReference type="OrthoDB" id="1880850at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000148">
        <property type="term" value="C:1,3-beta-D-glucan synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003843">
        <property type="term" value="F:1,3-beta-D-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006075">
        <property type="term" value="P:(1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051278">
        <property type="term" value="P:fungal-type cell wall polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026899">
        <property type="entry name" value="FKS1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056261">
        <property type="entry name" value="FKS1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003440">
        <property type="entry name" value="Glyco_trans_48_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741:SF48">
        <property type="entry name" value="1,3-BETA-GLUCAN SYNTHASE COMPONENT FKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741">
        <property type="entry name" value="LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14288">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23605">
        <property type="entry name" value="FKS1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02364">
        <property type="entry name" value="Glucan_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01205">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="577"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="610"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="666"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="717"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1345"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1397"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1488"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1514"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1603"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1650"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1692"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1727"/>
            <end position="1746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1798"/>
            <end position="1823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1846"/>
            <end position="1870"/>
        </location>
    </feature>
    <feature type="domain" description="1,3-beta-glucan synthase component FKS1-like" evidence="13">
        <location>
            <begin position="344"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1898"/>
            <end position="1920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU35034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1935" mass="220731" checksum="2F1137F14B12F459" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMN6</accession>
    <name>C7ZMN6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptide hydrolase</fullName>
            <ecNumber evidence="7">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_52779</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="7"/>
    <dbReference type="EMBL" id="GG698957">
        <property type="protein sequence ID" value="EEU34702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040415.1">
        <property type="nucleotide sequence ID" value="XM_003040369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMN6"/>
    <dbReference type="GeneID" id="9678838"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_52779"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_52779"/>
    <dbReference type="eggNOG" id="KOG2195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024336_1_1_1"/>
    <dbReference type="InParanoid" id="C7ZMN6"/>
    <dbReference type="OMA" id="LEQDACY"/>
    <dbReference type="OrthoDB" id="10013407at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04816">
        <property type="entry name" value="PA_SaNapH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF26">
        <property type="entry name" value="PEPTIDASE M28 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005125794" description="Peptide hydrolase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="8">
        <location>
            <begin position="125"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="9">
        <location>
            <begin position="246"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU34702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="494" mass="52635" checksum="60776CB37B5940BF" modified="2009-10-13" version="1">MKLTTAATLLTLLPSLGAAGKDRRPQVKSHKLQKLITEKGLMRNLQKLNDIAYANGGNRAFGLPGYDASVDFIYRELKKLKGFKAWKEDFPALYTDTTAAEVTVDDETFRTVALTYTPSTPEEGITGELVHGPEGEAGCSADNYEGLGAEGKIVLVERGRCPDATTFAGKLKAAAKAGAVAVVLYNSDPAKLTAGSLSNPNPDEYVPAALIDQEPGQALKARLDAGETVEAYVQIQQLIEERITQNVFAETKGGDAKNVVMLGAHLDSVKAGPGINDDGSGTSLILEVAKGLQHFSTNLKVKFGWWGAEENGLWGSRAYVNGLTPQEVDKLLVYLNFDMVSRGFYGVFDGTGERVGPGGPPGSDVVEDLFVEHFTSKGIEVTPVGLTGGTDYVPFLEVINKPVGGLFTGTGAEQDACYHQACDNITNPVPETITINAKAAAHVLSILAVDGKDLIPKTPSNVTTASIKRVRDAASLHEHDFTAVLGKFCDHDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZN01</accession>
    <name>C7ZN01_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_19159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698960">
        <property type="protein sequence ID" value="EEU34622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040335.1">
        <property type="nucleotide sequence ID" value="XM_003040289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZN01"/>
    <dbReference type="GeneID" id="9678750"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_19159"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_19159"/>
    <dbReference type="eggNOG" id="ENOG502SVUF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090700_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZN01"/>
    <dbReference type="OMA" id="FACERSI"/>
    <dbReference type="OrthoDB" id="3354680at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU34622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="173" mass="19036" checksum="9941BDBB2F17B365" modified="2009-10-13" version="1" fragment="single">LPRAVFVQSLRESSYLLPIRPEFLASSSAKLVNPRGHILNTDAVTQTFSASVVAGLSDERVLSLFTSGFFGGFVFGFERFILRIGGYRLLPARYTGFETPPDAATVWNKADVPNTHLLPVGSCLFGSFRLLTKHIAVVPSVEEPSYVDYGFGSDEFIFGGCHRFQITRLPVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZN37</accession>
    <name>C7ZN37_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_88853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698962">
        <property type="protein sequence ID" value="EEU34566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040279.1">
        <property type="nucleotide sequence ID" value="XM_003040233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZN37"/>
    <dbReference type="GeneID" id="9678088"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88853"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88853"/>
    <dbReference type="HOGENOM" id="CLU_470978_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZN37"/>
    <dbReference type="OrthoDB" id="5096628at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="579" mass="63597" checksum="F563C4C122E5CA94" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZN56</accession>
    <name>C7ZN56_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_88834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698963">
        <property type="protein sequence ID" value="EEU34539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040252.1">
        <property type="nucleotide sequence ID" value="XM_003040206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZN56"/>
    <dbReference type="GeneID" id="9678074"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88834"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88834"/>
    <dbReference type="eggNOG" id="ENOG502RPXK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_515886_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZN56"/>
    <dbReference type="OMA" id="YETPECA"/>
    <dbReference type="OrthoDB" id="5106994at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="431"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="528" mass="61024" checksum="CF8DE865F69484A8" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNF3</accession>
    <name>C7ZNF3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Histidinol dehydrogenase</fullName>
            <shortName evidence="6">HDH</shortName>
            <ecNumber evidence="6">1.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_94798</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-histidinol + 2 NAD(+) + H2O = L-histidine + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 11">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="6"/>
    <dbReference type="EMBL" id="GG698967">
        <property type="protein sequence ID" value="EEU34461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040174.1">
        <property type="nucleotide sequence ID" value="XM_003040128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNF3"/>
    <dbReference type="STRING" id="660122.C7ZNF3"/>
    <dbReference type="GeneID" id="9677989"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94798"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94798"/>
    <dbReference type="eggNOG" id="KOG2697">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006732_3_3_1"/>
    <dbReference type="InParanoid" id="C7ZNF3"/>
    <dbReference type="OMA" id="MTDRDDW"/>
    <dbReference type="OrthoDB" id="1703565at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000001">
        <property type="entry name" value="Histidinol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000026">
        <property type="entry name" value="Histidinol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1980">
        <property type="entry name" value="Nitrogenase molybdenum iron protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256:SF14">
        <property type="entry name" value="HISTIDINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="HISTIDINOL DEHYDROGENASE HDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU34461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="438" mass="47023" checksum="1762D3A0A93072CD" modified="2009-10-13" version="1">MTRTYVKRPAASGASGTKTNGSPVDVAGIVKGVIDTIRQQGDGAVRRYSEQFDKWSPTSFELSKEDIEKVLAELPEQVIQDIKTVQANVRKFAEAQKNSLKEFELEMAPGVVLGQKNNPIDSVGAYIPGGRYPLLASAHMTILTAKVAGVRNVVACTPPAAGKLPLATVAAMHLAGADRIFILGGIQAIAAMAVGTETIPKVDFIAGPGNAFVAEAKRQLFGEIGIDLFAGPTEVLIVADETADPYTVATDLLSQAEHGPDTPAVLITTSEDLAKRTIEYCDQQLASLKTAAVASVSWRDFGEVIVTDTIDEAYQVADEFASEHVQILTAKPRDALTKMQHYGALFLGPMTCVSFGDKCIGTNHVLPTKHAARYTGGLWVGKFLRTVTYQEVTSAEESGKLGRLCGRAARVELFEGHARSGDIRASLYLKDKFDWVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNG7</accession>
    <name>C7ZNG7_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_52809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698968">
        <property type="protein sequence ID" value="EEU34421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040134.1">
        <property type="nucleotide sequence ID" value="XM_003040088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNG7"/>
    <dbReference type="GeneID" id="9677957"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_52809"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_52809"/>
    <dbReference type="HOGENOM" id="CLU_013929_15_5_1"/>
    <dbReference type="InParanoid" id="C7ZNG7"/>
    <dbReference type="OMA" id="IIYISKT"/>
    <dbReference type="OrthoDB" id="5041117at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="58" mass="6788" checksum="3A09C6F8470B677E" modified="2009-10-13" version="1" fragment="single">EIKYLIRSSITYILKTKFFLAFYTIYKAIIIKRNIRGAFKGASFIPFDLEAIVLKLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPA8</accession>
    <name>C7ZPA8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_85654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040032.1">
        <property type="nucleotide sequence ID" value="XM_003039986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZPA8"/>
    <dbReference type="GeneID" id="9677671"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85654"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85654"/>
    <dbReference type="HOGENOM" id="CLU_1349272_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZPA8"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU34319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="203" mass="22731" checksum="F2620EEC6C208BDB" modified="2009-10-13" version="1">MPDEAPTNLEYFQGLIYERYPNDGVRKSRQRRKDANKENINVLVRGGSALRCFYTAAGSEKQVLPSRRYESHDGAPDEGGISWRCAIGPKANGLACLSGARLGTILLAQESTTTAVFPFHRDCFDVLKTAHYSAAVDPDLLYDTIRINCGRMVSCFEYVRTTLGEYIAPASTTPSRTFWRDQMLDSLKHHNTTADTMQIRKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPT8</accession>
    <name>C7ZPT8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_88032</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698973">
        <property type="protein sequence ID" value="EEU33957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039670.1">
        <property type="nucleotide sequence ID" value="XM_003039624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZPT8"/>
    <dbReference type="STRING" id="660122.C7ZPT8"/>
    <dbReference type="GeneID" id="9667192"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88032"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88032"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_312391_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZPT8"/>
    <dbReference type="OMA" id="MNDITED"/>
    <dbReference type="OrthoDB" id="2096480at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF7">
        <property type="entry name" value="RE15974P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="325"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU33957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="954" mass="105815" checksum="BA56B956413D11AD" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQD7</accession>
    <name>C7ZQD7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carotenoid oxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_56083</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698988">
        <property type="protein sequence ID" value="EEU33775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039488.1">
        <property type="nucleotide sequence ID" value="XM_003039442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQD7"/>
    <dbReference type="GeneID" id="9667006"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_56083"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_56083"/>
    <dbReference type="eggNOG" id="KOG1285">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016472_6_2_1"/>
    <dbReference type="InParanoid" id="C7ZQD7"/>
    <dbReference type="OMA" id="NPYTHHP"/>
    <dbReference type="OrthoDB" id="1069523at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF89">
        <property type="entry name" value="CAROTENOID 9,10(9',10')-CLEAVAGE DIOXYGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU33775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="59086" checksum="83753D787338A0DE" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQD9</accession>
    <name>C7ZQD9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_56114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698989">
        <property type="protein sequence ID" value="EEU33762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039475.1">
        <property type="nucleotide sequence ID" value="XM_003039429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQD9"/>
    <dbReference type="GeneID" id="9667003"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_56114"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_56114"/>
    <dbReference type="HOGENOM" id="CLU_2948156_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZQD9"/>
    <dbReference type="OrthoDB" id="448455at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU33762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="60" mass="6818" checksum="4D79936564040D96" modified="2009-10-13" version="1" fragment="single">GRTTLHYSTIKGNLTANILHFLCDEIRLSTGLRDSHRKTPLDYAVKIGKKDHNPNLFNPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQE6</accession>
    <name>C7ZQE6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_89162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698990">
        <property type="protein sequence ID" value="EEU33752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039465.1">
        <property type="nucleotide sequence ID" value="XM_003039419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQE6"/>
    <dbReference type="STRING" id="660122.C7ZQE6"/>
    <dbReference type="GeneID" id="9666995"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89162"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89162"/>
    <dbReference type="HOGENOM" id="CLU_510982_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZQE6"/>
    <dbReference type="OMA" id="QPHETFI"/>
    <dbReference type="OrthoDB" id="3261350at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="452"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU33752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="533" mass="58554" checksum="CE2BD7607E4AA988" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQT9</accession>
    <name>C7ZQT9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7703 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_56385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699011">
        <property type="protein sequence ID" value="EEU33618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039331.1">
        <property type="nucleotide sequence ID" value="XM_003039285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQT9"/>
    <dbReference type="STRING" id="660122.C7ZQT9"/>
    <dbReference type="GeneID" id="9666854"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_56385"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_56385"/>
    <dbReference type="eggNOG" id="ENOG502SMNP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045148_0_2_1"/>
    <dbReference type="InParanoid" id="C7ZQT9"/>
    <dbReference type="OMA" id="FNAVVCH"/>
    <dbReference type="OrthoDB" id="405906at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="2">
        <location>
            <begin position="12"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU33618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="377" mass="42219" checksum="E02703423F2B4CDB" modified="2009-10-13" version="1">MKSRGFGSGVDGFSQTSVTIIIVFLAISLHNFIELNCIIWWTFKRHAGLYFWSFVVATWGIPLYCAGFLTKYLGSPSLGYFSCTLIVIGWICLVTGQSMVLWSRVHLVLRDRKLLKMILWMIITNAIVCHGAIIPMVYGSFSSSPEMWQKPYTIIEKIEVTAFFLQEVILSGFYIVETVKLMRLERAMGNTESSRRLMKHLILVNVLIILLDITILGLEYANQYEYQTAYKCFVYSTKLKLEFTILNRLVEMTTGNKDISSGSRSRNNITLNKTSVALKTLVGDAGGKPTGGVSYPAYAREGGEGSNDSVQMSPTRDDNRVMMTTEIVVHRVERRDDETGSNCRKLSVDSTIGVTKAFDGEAVSKSSSEVDFATHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7YGY4</accession>
    <name>C7YGY4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peroxisomal membrane protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_74783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054251.1">
        <property type="nucleotide sequence ID" value="XM_003054205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YGY4"/>
    <dbReference type="STRING" id="660122.C7YGY4"/>
    <dbReference type="GeneID" id="9664332"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74783"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74783"/>
    <dbReference type="eggNOG" id="ENOG502RXMH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054132_1_0_1"/>
    <dbReference type="InParanoid" id="C7YGY4"/>
    <dbReference type="OMA" id="VMVFLFR"/>
    <dbReference type="OrthoDB" id="39659at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019531">
        <property type="entry name" value="Pmp4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460:SF3">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013674">
        <property type="entry name" value="PXMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU48538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="25537" checksum="61DCE42AE52C74A0" modified="2009-10-13" version="1">MASSAMIEVVKNALEEIVKDPRYHDLLSLIKTARNGAVYGTKVRFPHALVMIFLFRSGTFRYKAGLVLRATRHHASNLARFAVIYKLTMLALKYFGSTPGKEGTYDSFVGGLVGGYFVFGGRSKRTGKISSVNQQIVIYVFARVMLALARIAVKPGHGFPLVSSEPLHSTISHYAWPAFASLSWAMVMLVFRYHPEDLQSSLRSSMTYIYKDCNDFDSLRTLLWHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHZ1</accession>
    <name>C7YHZ1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">S5 DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_32108</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053712.1">
        <property type="nucleotide sequence ID" value="XM_003053666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YHZ1"/>
    <dbReference type="STRING" id="660122.C7YHZ1"/>
    <dbReference type="GeneID" id="9674735"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_32108"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_32108"/>
    <dbReference type="eggNOG" id="KOG2646">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037994_1_0_1"/>
    <dbReference type="InParanoid" id="C7YHZ1"/>
    <dbReference type="OMA" id="IYEMCRA"/>
    <dbReference type="OrthoDB" id="309483at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000041">
        <property type="entry name" value="37S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="6">
        <location>
            <begin position="334"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU47999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="498" mass="55564" checksum="7F15E96680F53CCA" modified="2009-10-13" version="1">MSVARPARTLLGRCLASSRTTTTTLPAVPCHQFHSSAPRSKRKSRFRNVTAQELGLLSTPEKMDQYKKEHFAEYTPEEKDLLKGHYSKQQMEAIEAGEKAVDTEDMVIQGRLRDDPYKPEYIEDYTVLDPRYDLKPEIEGTPREVQWPSTSEWLDNYGQKMRSITDKKTSDQLTRAMIRALRRVKESQGEDLIDLTEAELEDMEKDPELAKRYIIEEDGPEPDANSKGPEFMTRAQAMKADEAVDEAWKQELDKIVGFGSQGEVEPSSIELIEDGPAGIDRAHSAEAADLGKVPGVHGLYKHAVDPEDQGQDDSGKYQEIKRLTGMSLKEIRSLLTKGLVTRWVANQTRLGKVRSTSVVAIAGNGNGRLGLGMAKSTEPGVAEETAQMLAIRNMKPVRRYENRTIYGNVSAKVSGTVVELMARPPGFGLRVPHRIFEMCRAAGIHDMAARMPRSKNPMNSVKAAYQALTNQPDPEQIAIGRGKKLVDVRKVYYGGAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHZ3</accession>
    <name>C7YHZ3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_90257</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054434.1">
        <property type="nucleotide sequence ID" value="XM_003054388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YHZ3"/>
    <dbReference type="FunCoup" id="C7YHZ3">
        <property type="interactions" value="102"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YHZ3"/>
    <dbReference type="GeneID" id="9664740"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90257"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90257"/>
    <dbReference type="eggNOG" id="KOG0750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053371_0_0_1"/>
    <dbReference type="InParanoid" id="C7YHZ3"/>
    <dbReference type="OMA" id="GQPWFSD"/>
    <dbReference type="OrthoDB" id="409947at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001409">
        <property type="term" value="F:guanine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000010">
        <property type="entry name" value="Probable YHM1 (Mitochondrial carrier)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053042">
        <property type="entry name" value="Mito_GTP/GDP_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974">
        <property type="entry name" value="MITOCHONDRIAL GTP/GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974:SF1">
        <property type="entry name" value="MITOCHONDRIAL GTP_GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="211"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU48721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="32849" checksum="9C6E85D2E0F600DD" modified="2009-10-13" version="1">MSPPVASGREKESNLARLLGSGSAGIAELAIFHPVDTIAKRLMSNQSRVASASQLNQVIFKDKASATVGRKFVSLFPGLGYAAGYKVLQRIYKYGGQPVARDYLGKHYGADFENAFGKKTGKAIMHSTAGSLIGIGEIVLLPLDVLKIKRQTNPEAFRGRGVLKIVADEGFGLYRGWGWTAARNAPGSFALFGGSAFAKEYLFHLEDYNKASWFQNFIASIAGASASLVVSAPLDVIKTRIQNRNFDNPESGFRILANMAKNEGPSSFFKGLVPKLLMTGPKLVFSFWLAQTLIPAFDAAFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7YI41</accession>
    <name>C7YI41_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_98909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054454.1">
        <property type="nucleotide sequence ID" value="XM_003054408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YI41"/>
    <dbReference type="STRING" id="660122.C7YI41"/>
    <dbReference type="GeneID" id="9664498"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_98909"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98909"/>
    <dbReference type="eggNOG" id="ENOG502SFYT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078262_1_0_1"/>
    <dbReference type="InParanoid" id="C7YI41"/>
    <dbReference type="OMA" id="ESNRWAV"/>
    <dbReference type="OrthoDB" id="1681166at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU48741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="232" mass="25032" checksum="A689958747DE9859" modified="2009-10-13" version="1">MSGTDRDPSPPITASGLAPAAELLHEQQQQQPEDEAPLEPPMPPFEPLFALLTNSTTNTTVHPRIHYLFSDDDPSVLASPAVDRALVVDLVPAPEGDSSRWAVSWAASLTPDFAVTTSNVAVQQSEGDDDGRNGGALMLRVEGVEREPVEMRPDSLPSSGSGAIGGEDVDVLAEDFRRRMGVLKKVVDEGEKRRALVGQEHEDEQVDEDEGPPDEAIVDYDSVEKGKEKAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7YI65</accession>
    <name>C7YI65_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_75211</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054462.1">
        <property type="nucleotide sequence ID" value="XM_003054416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YI65"/>
    <dbReference type="GeneID" id="9664768"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75211"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75211"/>
    <dbReference type="eggNOG" id="ENOG502RZ32">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024803_1_0_1"/>
    <dbReference type="InParanoid" id="C7YI65"/>
    <dbReference type="OMA" id="RGYYMGT"/>
    <dbReference type="OrthoDB" id="19092at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000283">
        <property type="entry name" value="NAP1-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="297"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="92"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="152"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="251"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="370"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="375"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="448"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="464"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU48749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="507" mass="55458" checksum="BAA3C2FB9E173F73" modified="2009-10-13" version="1">MSTTSSPATSPPAAASSPPNPNHPALPPLITSPPSRRSITSRPMSHASRSRLSQYSTGSLPTRSRPTSHLIPMFPSTLPYTQVRDFAYPVTHPLHYGPPPEPSGPPSGMTTPASEHRRLSDPPASWDQKMPWDSWGTDVYNRGHELAPIQFGDGPPWSEDEDLQSPVVATRHRKHKSTSAAAALRGRTRDVDLHPTNFDHERGYYVGTGGDGSERYYVNNGGEANGPGGEYVTYPPDQARHSRAYHIAQQPRPADGGEYYQPGSDASSPPSSPGYNEEDQSRYSRDYQFTITSPDEEFHGKAVALFDFERENENELPLVEGQIIWVSYRHGQGWLVAEDPKTQESGLVPEEYVRLLRDIEGGMNSLTGQLVEGNGSPNDVGTPTQAEHSGQYGHTPSSSNATNGYNQPIVSMFSTSSRDLDPYPTQQLGLHSGQAPPQVIHYHGQRGGSQANTPTMAQTQDVGMLRRESHDSGRQRDSTSTPVQAKPPMELPEPGGVEEAAEKEKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIH3</accession>
    <name>C7YIH3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Folylpolyglutamate synthase</fullName>
            <ecNumber evidence="17">6.3.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Folylpoly-gamma-glutamate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Tetrahydrofolylpolyglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">NECHADRAFT_90362</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </cofactor>
        <text evidence="17">A monovalent cation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 17">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="17"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053810.1">
        <property type="nucleotide sequence ID" value="XM_003053764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIH3"/>
    <dbReference type="FunCoup" id="C7YIH3">
        <property type="interactions" value="721"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YIH3"/>
    <dbReference type="GeneID" id="9664642"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90362"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90362"/>
    <dbReference type="eggNOG" id="KOG2525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015869_0_1_1"/>
    <dbReference type="InParanoid" id="C7YIH3"/>
    <dbReference type="OMA" id="ESLDCCM"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Folylpolyglutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Folylpolyglutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
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        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023600">
        <property type="entry name" value="Folylpolyglutamate_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038895">
        <property type="entry name" value="FPGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 17" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="19">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR038895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EEU48097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="490" mass="54300" checksum="C20B7AD49163A059" modified="2009-10-13" version="1">MASSSRSYNDAIDALNSLQTPFDIIEARRKAGIRPDAVSIKEMKTYLHRIGYTPADLDRLKIVHVAGTKGKGSTCAFVDSILSQYQNSYPALRKTGLFTSPHLIAVRERIRINSTPISEELFAKYFFQVWDRLEAAPKGEGDELMAPRPIYARYLTLMSWHVFLQEGVDVAVYETGIGGEYDATNVVERPVASGISTLGIDHVFALGDTVAKIAWHKAGIMKTGSAAFTIEQVPDADEVLRKRAVEKKVDLKVLDIDPRLEAVKIRPDAVFQKRNATLAVALAETALEKVGVPLPPKTGPLPKEFVEGLEKVVWRGRCEVKKEEKVTWHVDGAHTSDSLKMSAKWFKDETSGRTGPRVMIFNQQGRSEAVDFLDSVFKATRRDGKPAFDHVIFCTNVTYAASGYKRDFVNRQYDPAEIDKMTVQHRFAEKWSALDPEADVKVMPTIEQSIDFARHVGEGLPEGETVQALITGSLHLVGGALGILEKADAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIP1</accession>
    <name>C7YIP1_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_75392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053842.1">
        <property type="nucleotide sequence ID" value="XM_003053796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIP1"/>
    <dbReference type="GeneID" id="9676474"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75392"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75392"/>
    <dbReference type="HOGENOM" id="CLU_1896771_0_0_1"/>
    <dbReference type="InParanoid" id="C7YIP1"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU48129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="134" mass="14847" checksum="4AB8321F0FB09FC9" modified="2009-10-13" version="1">MSPKGKGHRSHKHKKSSSSSQPQDDEIPIDPSLTDPSYTAYTQDYAQAGPSSYAQWQQQPATVNPNDLWINQDASSSSAAQGYYAADPAYQDADYDELNWELDEQAGSSSAAAAQQDYQCEECGRICRGRREYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIZ7</accession>
    <name>C7YIZ7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Azaphilone pigments biosynthesis cluster protein L N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_75501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054607.1">
        <property type="nucleotide sequence ID" value="XM_003054561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIZ7"/>
    <dbReference type="GeneID" id="9663676"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75501"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75501"/>
    <dbReference type="HOGENOM" id="CLU_678085_0_0_1"/>
    <dbReference type="InParanoid" id="C7YIZ7"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU48894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="406" mass="44077" checksum="8D96FFF7D08A2630" modified="2009-10-13" version="1">MEAIGVGANVLAFVVLGIKSAKLAHDTLSAISDGPARVRNLAADFLQLHWILEQLLQCRAAETDTALHGQARQCCETLGKLAKTIERLQVSPGERATGRFWKRLKAAISESDLEKLGPWVAQQTSMLSLRLNVLSRDAMETQFVTQTATIQGAAQSIMSSHNDGRSALEAGLSSIQQTIEATHSISSGNTQSMFQILKEIKDCIIPESKHNPGMNNSSGDDENAMDEDAPGLDQKLLDSIDSLCGLIDERRDAVDAYEEDDDQAQSAIENLEGLIQNLRGQKLTVSDPKSFGSDLARFGKWFGSGALSINSGGSLVFDVEMLQDGEASLQDHDEYGASLLFYSLEHPEVCRFLIDSGLDVDHIGGIPGLPQFQVHTAGMILRRSLKSCGRSWSLAGFCYMQALTHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJP9</accession>
    <name>C7YJP9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DJ-1/PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_75755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054025.1">
        <property type="nucleotide sequence ID" value="XM_003053979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJP9"/>
    <dbReference type="STRING" id="660122.C7YJP9"/>
    <dbReference type="GeneID" id="9676649"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75755"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75755"/>
    <dbReference type="eggNOG" id="ENOG502SMQ8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_44_8_1"/>
    <dbReference type="InParanoid" id="C7YJP9"/>
    <dbReference type="OMA" id="DMEFHWV"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF7">
        <property type="entry name" value="DJ-1_PFPI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="1">
        <location>
            <begin position="60"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU48312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="218" mass="23866" checksum="857B575699E679D8" modified="2009-10-13" version="1">MAAKFSLSNPTRPIRVGVVLMNGVTELLDIAPVGMLHGLSKEFVESFPDELLAPSLKAQAVDFKFHWVSEFGEAAHSRLSGGMSILPMDSFQSCPPLDIILIGAHNFGYTPNTAELAFIRKCWDECSAFLTVCGGVQVPLLAGLLEGKTATGPRSMLGMLRREAPGTNWVERRWARDGRLWTSGALLNGTDLLNAFAHEYWGRGDVGSLMRQPATDFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7YKZ8</accession>
    <name>C7YKZ8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_77351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052420.1">
        <property type="nucleotide sequence ID" value="XM_003052374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YKZ8"/>
    <dbReference type="GeneID" id="9671409"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77351"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77351"/>
    <dbReference type="HOGENOM" id="CLU_316188_0_0_1"/>
    <dbReference type="InParanoid" id="C7YKZ8"/>
    <dbReference type="OMA" id="FSELWEM"/>
    <dbReference type="OrthoDB" id="2951834at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="2">
        <location>
            <begin position="675"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="26"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU46707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="923" mass="101178" checksum="A25DE3FD702B9C01" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7YL70</accession>
    <name>C7YL70_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_103650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052921.1">
        <property type="nucleotide sequence ID" value="XM_003052875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YL70"/>
    <dbReference type="STRING" id="660122.C7YL70"/>
    <dbReference type="GeneID" id="9663612"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_103650"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_103650"/>
    <dbReference type="eggNOG" id="KOG2793">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036731_0_0_1"/>
    <dbReference type="InParanoid" id="C7YL70"/>
    <dbReference type="OMA" id="LYENLDW"/>
    <dbReference type="OrthoDB" id="413520at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF132">
        <property type="entry name" value="PROTEIN-LYSINE METHYLTRANSFERASE C42C1.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU47208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="425" mass="47344" checksum="A2D2E6B2160E4008" modified="2009-10-13" version="1">MHYIRFLRAPKVLKNRRGTLVQLLFTITTDLGDSFLLPERFLDLQVVAVAASPEGSSTWLLSDPGHLDWEPGMRVAKPALELPVALERALETGMRVHICVRAAESIHTAESAPRVLALAAEKMRYRKEAAAKGAVMPAWVPLLVTEPGSEVSIRRLQLGDSPDGLGTIELEEEIGESIARHVWDAGVVATSAIVGIETAPDSESSNDPCMRTLKNIFSRQRTIRVLELGCGVGILSVGLAAVYPQLHAPSPGDCTILMTDLPEAEERARSNMKRVENSHVRFQEKPVRMMYENLDWEEGRQGRFGPQARSQPWDVVMLSDCTYNVDMLPALVETLSAIHANNLTHFPEGEPFTTKVFLATKPRHESEEVLFELMDKDGWYNVHRQVMPLPVLGGAPQSVELYLFDKSGLSEDRDHGRGERERERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7YL94</accession>
    <name>C7YL94_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_77450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052933.1">
        <property type="nucleotide sequence ID" value="XM_003052887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YL94"/>
    <dbReference type="STRING" id="660122.C7YL94"/>
    <dbReference type="GeneID" id="9663624"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77450"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77450"/>
    <dbReference type="eggNOG" id="KOG1235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_1_3_1"/>
    <dbReference type="InParanoid" id="C7YL94"/>
    <dbReference type="OMA" id="AGWAVRY"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF11">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002987358" description="Beta-lactamase-related domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="74"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU47220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="429" mass="47239" checksum="6C127E4A3D04DA98" modified="2009-10-13" version="1">MKFHAALLAVVAPSLTSANFVLRHGQPSSVGMLAKPLKDMVQNITEYSKPRNYGDASHNEVRAIEPGSANIVARHGVIVSAFATGKRNLYADANGTLLDPADQEDAALDTVYDLASISKLFTAVAVLREVDAGRVKLEENVSTYLPEFAANGKGNIKVIDLLTHTSGLMPLPVPDLWKSYYSSIDQRVHTLLTLPPQEPRRTKFLYSDIGFMTLRYLLERVTGLNHELLIYSYTIPLGMRSTFFNRGNLEGPLNPFHNRTAPTEFEIEAQGPEEPKRPQPVRGTVHDENTWALGGVSGHAGVFSTVGDVAIFCQMILNNGVYNGHRVLSKKAVDLIFTDFNAQFPGNNYGAGFALNQTYTQGSMQSMKTASHAGFTGTTLAIDRPSGTFWLHFANRVHPSRHWATNNPARRAMGYWVAKSLGRNVPWPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLD7</accession>
    <name>C7YLD7_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_8744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052955.1">
        <property type="nucleotide sequence ID" value="XM_003052909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YLD7"/>
    <dbReference type="GeneID" id="9671014"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_8744"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_8744"/>
    <dbReference type="eggNOG" id="ENOG502S5M9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073624_2_1_1"/>
    <dbReference type="InParanoid" id="C7YLD7"/>
    <dbReference type="OMA" id="QGIDFCK"/>
    <dbReference type="OrthoDB" id="2142503at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36854">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36854:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002987362" evidence="2">
        <location>
            <begin position="21"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU47242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="142" mass="15351" checksum="B78F615E4DB0F453" modified="2009-10-13" version="1" fragment="single">MARISFIILLLGAFISLAAASAPTFCKCTCFKNSTIIPLGPKGERSPSQLRRSAVLDYGDFTPANDIRSASALEPRSKSKSCSECTKAFCLKQGISFCKGATEEDVTTLCFQRDSNKDKIIVWGFIIGTVGLLGWAAFKKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7YN63</accession>
    <name>C7YN63_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_78119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052782.1">
        <property type="nucleotide sequence ID" value="XM_003052736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YN63"/>
    <dbReference type="GeneID" id="9671314"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78119"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78119"/>
    <dbReference type="HOGENOM" id="CLU_1349275_0_0_1"/>
    <dbReference type="InParanoid" id="C7YN63"/>
    <dbReference type="OrthoDB" id="5098910at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU47069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="203" mass="22231" checksum="2C5D9140F68B1B63" modified="2009-10-13" version="1">MACDLVKGTRLDLVSLSRSMLKSHHQQHSRESNRPPTMAPDPMTDEMKEDIRRMTETLTNQSTIELLTRAGNQAKYNRWDLKERKKAREEAMARAENDGNAGDYEEDVTRDTEASVADTTGINEANVTDAGANETNATDVSEAKSKVTTKVTTKVTTKVKDVVSRVTKAMNRLSMTKKGAGDKTAADDKGKSGHGSKQGDNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNQ2</accession>
    <name>C7YNQ2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1295 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_68672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052330.1">
        <property type="nucleotide sequence ID" value="XM_003052284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNQ2"/>
    <dbReference type="GeneID" id="9672946"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_68672"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_68672"/>
    <dbReference type="eggNOG" id="KOG4650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043418_0_1_1"/>
    <dbReference type="InParanoid" id="C7YNQ2"/>
    <dbReference type="OMA" id="WRKGGYQ"/>
    <dbReference type="OrthoDB" id="201504at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF23">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU46617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="41261" checksum="4DC47CEFD961659F" modified="2009-10-13" version="1">MAFPFLKSIEDCGDYAKTVEPFIPQLYALPGQIVDNIADPSGLRQLYIDTNPLISAFAASVTSSFIFLVVSEINRNYSQIDRMWSLLPNLYVVHLAVWARLAGVPSSRIDLVAAATTVWSCRLTYNYWRKGGYNVGSEDYRWAILQKYVPRFIFFIFNVTFISFIQSVLLFAFSCVPAYAILLSTKFEPNITTADVAYFVAEIALVFSEWVSDGQQWDYHQAKHQYQKDAKVPRNYNYTQAQLDRGFNTSGLWAYSRHPNFAAEQLVWFVLYQWSCFATNNLYSYTFAGSGALILLFQGSTWLTERITAGKYYEYSMYQKNVGMFMPTSFRPYKTPVQQPKVIRTSEIAKRMENKKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPR4</accession>
    <name>C7YPR4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_59954</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051608.1">
        <property type="nucleotide sequence ID" value="XM_003051562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YPR4"/>
    <dbReference type="SMR" id="C7YPR4"/>
    <dbReference type="GeneID" id="9673280"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_59954"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_59954"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="InParanoid" id="C7YPR4"/>
    <dbReference type="OMA" id="GVFVYYM"/>
    <dbReference type="OrthoDB" id="648285at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000119">
        <property type="entry name" value="MFS monosaccharide transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF73">
        <property type="entry name" value="METABOLITE TRANSPORT PROTEIN YDL199C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="16"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="468"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU45895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="562" mass="61728" checksum="5F376E0CD8E40F77" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPW7</accession>
    <name>C7YPW7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_100005</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051635.1">
        <property type="nucleotide sequence ID" value="XM_003051589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YPW7"/>
    <dbReference type="GeneID" id="9668788"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100005"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100005"/>
    <dbReference type="eggNOG" id="ENOG502TFCQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1547715_0_0_1"/>
    <dbReference type="InParanoid" id="C7YPW7"/>
    <dbReference type="OMA" id="VKPKWIM"/>
    <dbReference type="OrthoDB" id="2155283at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050897">
        <property type="entry name" value="SMAUG/VTS1_RNA-bind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515:SF5">
        <property type="entry name" value="PROTEIN SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="117"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU45922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="170" mass="19090" checksum="D66F3578C186353D" modified="2009-10-13" version="1">MSSYSSFSSSISGSASSSPSLSFRSHVSSQSDSERVGEEMDIIKTWFSVLNDEERTAALTSIAELPCLREIEPLIQTLKDRKRDLWRRQEDLLIQPGTKPKWPMPAFPHNSQDPRWVAKWLRALRLHKYENCLTGMSPAQVSRLSDADLQQLGVDTVGARTKLLRAISSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQ97</accession>
    <name>C7YQ97_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ADP-ribosylation factor GTPase-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_60108</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase-activating protein for the ADP ribosylation factor family.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051695.1">
        <property type="nucleotide sequence ID" value="XM_003051649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQ97"/>
    <dbReference type="STRING" id="660122.C7YQ97"/>
    <dbReference type="GeneID" id="9673451"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_60108"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_60108"/>
    <dbReference type="eggNOG" id="KOG0521">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002728_0_0_1"/>
    <dbReference type="InParanoid" id="C7YQ97"/>
    <dbReference type="OMA" id="ITPNAFP"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07608">
        <property type="entry name" value="BAR_ArfGAP_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000051">
        <property type="entry name" value="ARF GTPase activator (Csx2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000252">
        <property type="entry name" value="ARF GTPase activator (Csx2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000017">
        <property type="entry name" value="ARF GTPase activator (Csx2), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045258">
        <property type="entry name" value="ACAP1/2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180:SF160">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN EFFECTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180">
        <property type="entry name" value="CENTAURIN/ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="628"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="8">
        <location>
            <begin position="808"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="511"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="765"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1040"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="544"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="557"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="573"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="768"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1062"/>
            <end position="1071"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU45982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1089" mass="120352" checksum="1A01EF3BBE3095B4" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C7YR68</accession>
    <name>C7YR68_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Guanine nucleotide-binding protein alpha-2 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_40554</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051115.1">
        <property type="nucleotide sequence ID" value="XM_003051069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YR68"/>
    <dbReference type="FunCoup" id="C7YR68">
        <property type="interactions" value="496"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YR68"/>
    <dbReference type="GeneID" id="9666509"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_40554"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_40554"/>
    <dbReference type="eggNOG" id="KOG0082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014184_6_0_1"/>
    <dbReference type="InParanoid" id="C7YR68"/>
    <dbReference type="OMA" id="INYGHPD"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000009">
        <property type="entry name" value="Guanine nucleotide-binding protein G(O) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000051">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF242">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-1 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="179"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="204"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="273"/>
            <end position="276"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU45402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="358" mass="41396" checksum="EFD4F048F2C934A4" modified="2009-10-13" version="1">MCFGSRDKGDRGQARSRDIDRQIRQDEKRLSKEVKLLLLGAGESGKSTVLKQMKLIYSQGFSKNEKLEWKPVIFSNIVQSFKVISEAMSEHNIAFENPDNEATLQKHMAHLLVEHELSPHDRMPVDYLEPIKALWADSGVRSAVELGNEYALHDNLTYFVEDVDRLWAEDYVPDDQDLLRSRLRTTGITETIFDLGQLTYRMFDVGGQRSERKKWIHCFENVNCLLFLVAISGYDQCLVEDKDGNQMNEALMLWESIANSHWFTKSALILFLNKMDLFKEKLPKSPITNHGFTDYHGPKDDYKAASKYFLDKFKALNRNTEKEIYGHFTNATDTNLLKITMASVQDMIIQRNLKQLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRG8</accession>
    <name>C7YRG8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UDP-N-acetylglucosamine transferase subunit ALG13</fullName>
            <ecNumber evidence="2 7">2.4.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 7">Asparagine-linked glycosylation protein 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ALG13</name>
        <name evidence="9" type="ORF">NECHADRAFT_106135</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 7">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UDP-N-acetyl-alpha-D-glucosamine = an N,N'-diacetylchitobiosyl-diphospho-di-trans,poly-cis-dolichol + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23380"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19510"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57269"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.4.1.141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1 7">Heterodimer with ALG14 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.141" evidence="2 7"/>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051169.1">
        <property type="nucleotide sequence ID" value="XM_003051123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YRG8"/>
    <dbReference type="FunCoup" id="C7YRG8">
        <property type="interactions" value="318"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YRG8"/>
    <dbReference type="GeneID" id="9665880"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_106135"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_106135"/>
    <dbReference type="eggNOG" id="KOG3349">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085408_2_1_1"/>
    <dbReference type="InParanoid" id="C7YRG8"/>
    <dbReference type="OMA" id="ILDAWKM"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052474">
        <property type="entry name" value="UDP-GlcNAc_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47043">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47043:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 28 C-terminal" evidence="8">
        <location>
            <begin position="12"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU45456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="210" mass="23468" checksum="55A1CE2ABF818535" modified="2009-10-13" version="1">MTSDSDRAGRLCLVTVGATVGFRKLTEAALDPIFWKYLVSQGFTELHVQCGPDVAWASKELIARKDDAPRGLNIDIFDMRNNLAKEEMTLCKPLDGKRQLGLVISHAGTGTILDAWKLGLPIIVVPNTQLLNDHQTEMAKHLSKEGYAIMSTSSVDDLQEAMHKVELLWEDNKSRWPPNKVPSAGNDRRRLWDLAPHEVAKEQNATMTHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRM2</accession>
    <name>C7YRM2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_100554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050811.1">
        <property type="nucleotide sequence ID" value="XM_003050765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YRM2"/>
    <dbReference type="GeneID" id="9667894"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100554"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100554"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_672843_0_0_1"/>
    <dbReference type="InParanoid" id="C7YRM2"/>
    <dbReference type="OrthoDB" id="195446at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU45098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="409" mass="45310" checksum="1CD2D76010010504" modified="2009-10-13" version="1">MNTGRESVVICEVPTEINQPPHTAAKAAMIGMKKGIRRGPFFALRESPLIGISGYFSFIRKQSPLTDVSDYTVDRSGPRNWPSTATVDPRTGEYQVPYNPEVLSSGFAFDMSWIEQEIAQLADPGQASHQHGQIATKELENIVCSLPDFLVRTAWRFWANLLVESRLMQHAKVIPHSVAVVQYYLHCGALKLEAGTQSSGATVVVLNCGEMLVDCVPYLLKGRPTTYSHVDVCPCKTSYMAEMAGFKHAQAEFVKIAAQKLIDFNQKLRSKVKSAEIEKRLKILSEYFTRVILPGFQNSGKSWEIPFDLPGRTGGVSSRLTFTDSEVLSCLNPSVSMVRKMLEHTVILVQPQYEVTHVLLAGPYSASKHLVKELTECLKSVQRRPAKLLNHADASDICVLGTLTHAISC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRU6</accession>
    <name>C7YRU6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Clock-controlled protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_104502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051237.1">
        <property type="nucleotide sequence ID" value="XM_003051191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YRU6"/>
    <dbReference type="STRING" id="660122.C7YRU6"/>
    <dbReference type="GeneID" id="9668008"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_104502"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_104502"/>
    <dbReference type="eggNOG" id="ENOG502S7XK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092869_4_0_1"/>
    <dbReference type="InParanoid" id="C7YRU6"/>
    <dbReference type="OMA" id="CTITRPV"/>
    <dbReference type="OrthoDB" id="4094614at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038843">
        <property type="entry name" value="Sed1/Spi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35523">
        <property type="entry name" value="CELL WALL PROTEIN SED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35523:SF1">
        <property type="entry name" value="CELL WALL PROTEIN SED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988225" description="Clock-controlled protein 6" evidence="2">
        <location>
            <begin position="20"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU45524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="14623" checksum="912EA0296FA348B4" modified="2009-10-13" version="1">MKFAAALAFAAGVSAYAKGNVTYTTEVVTAYTTYCPGPTEITHGGKTYTITEATTLTITDCPCTITKPVITTSAVVCHDCPAPPPAKGGNSTFVPVVPTGTAPVKPGNPEGPAATPTGGAPSEVPTAGAGKVAALSGAGLAAVVGLAAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRZ5</accession>
    <name>C7YRZ5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">M protein, serotype 2.1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_93716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050869.1">
        <property type="nucleotide sequence ID" value="XM_003050823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YRZ5"/>
    <dbReference type="STRING" id="660122.C7YRZ5"/>
    <dbReference type="GeneID" id="9666037"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_93716"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_93716"/>
    <dbReference type="eggNOG" id="ENOG502QVZ5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015321_0_0_1"/>
    <dbReference type="InParanoid" id="C7YRZ5"/>
    <dbReference type="OMA" id="METIYEA"/>
    <dbReference type="OrthoDB" id="2121319at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38120">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38120:SF1">
        <property type="entry name" value="M PROTEIN, SEROTYPE 2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="393"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="230"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="473"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="503"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="526"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU45156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="622" mass="68421" checksum="91FC7FF5AC072A5C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7YTA0</accession>
    <name>C7YTA0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_80233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU44997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050710.1">
        <property type="nucleotide sequence ID" value="XM_003050664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YTA0"/>
    <dbReference type="GeneID" id="9666485"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_80233"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_80233"/>
    <dbReference type="eggNOG" id="ENOG502S96F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127592_0_2_1"/>
    <dbReference type="InParanoid" id="C7YTA0"/>
    <dbReference type="OMA" id="QICWLEI"/>
    <dbReference type="OrthoDB" id="447346at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd07247">
        <property type="entry name" value="SgaA_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052164">
        <property type="entry name" value="Anthracycline_SecMetBiosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33993">
        <property type="entry name" value="GLYOXALASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="12"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU44997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="142" mass="15838" checksum="7DE371E65D729E2A" modified="2009-10-13" version="1">MDESRVQEALGQICWLEVPVRDFARAKKFYTEIFGWEVMDEPAKAVGDCVKSMHFFNKGKTLHGAFLELDEPYHVVNNIAERPAALPLMPTLCVVDCEETLKKVASAGGKTALPKTAIGGEMGYFARLIDTEENMIGIWSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7YTS0</accession>
    <name>C7YTS0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protection of telomeres protein 1 ssDNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_105275</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the telombin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050383.1">
        <property type="nucleotide sequence ID" value="XM_003050337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YTS0"/>
    <dbReference type="STRING" id="660122.C7YTS0"/>
    <dbReference type="GeneID" id="9674791"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_105275"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_105275"/>
    <dbReference type="eggNOG" id="KOG4757">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016663_0_0_1"/>
    <dbReference type="InParanoid" id="C7YTS0"/>
    <dbReference type="OMA" id="WEPHASF"/>
    <dbReference type="OrthoDB" id="2186770at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000783">
        <property type="term" value="C:nuclear telomere cap complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098505">
        <property type="term" value="F:G-rich strand telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010521">
        <property type="term" value="F:telomerase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032210">
        <property type="term" value="P:regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000303">
        <property type="entry name" value="Protection of telomeres protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028389">
        <property type="entry name" value="POT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032042">
        <property type="entry name" value="POT1PC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513">
        <property type="entry name" value="PROTECTION OF TELOMERES 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513:SF0">
        <property type="entry name" value="PROTECTION OF TELOMERES PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16686">
        <property type="entry name" value="POT1PC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Protection of telomeres protein 1 ssDNA-binding" evidence="9">
        <location>
            <begin position="86"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="262"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="490"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="272"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU44670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="574" mass="65537" checksum="8B9CFE19A21C4FCB" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7YU46</accession>
    <name>C7YU46_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_63603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050451.1">
        <property type="nucleotide sequence ID" value="XM_003050405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YU46"/>
    <dbReference type="FunCoup" id="C7YU46">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YU46"/>
    <dbReference type="GeneID" id="9665424"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_63603"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_63603"/>
    <dbReference type="eggNOG" id="ENOG502RVGM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022749_0_0_1"/>
    <dbReference type="InParanoid" id="C7YU46"/>
    <dbReference type="OMA" id="ADWNIYT"/>
    <dbReference type="OrthoDB" id="4138492at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF11">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU44738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="561" mass="59780" checksum="EC0FC0D5A36ED41C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7YUA9</accession>
    <name>C7YUA9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_101654</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050094.1">
        <property type="nucleotide sequence ID" value="XM_003050048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YUA9"/>
    <dbReference type="STRING" id="660122.C7YUA9"/>
    <dbReference type="GeneID" id="9674879"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101654"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101654"/>
    <dbReference type="eggNOG" id="KOG1175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_3_3_1"/>
    <dbReference type="InParanoid" id="C7YUA9"/>
    <dbReference type="OMA" id="TGWIMYM"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF4">
        <property type="entry name" value="ACETOACETYL-COA SYNTHASE (AFU_ORTHOLOGUE AFUA_8G04770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="4">
        <location>
            <begin position="40"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="118"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="580"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU44381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="700" mass="77490" checksum="FBBFA0B3C8EA2185" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>C7YUS8</accession>
    <name>C7YUS8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TrmE-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_96380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050176.1">
        <property type="nucleotide sequence ID" value="XM_003050130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YUS8"/>
    <dbReference type="FunCoup" id="C7YUS8">
        <property type="interactions" value="458"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YUS8"/>
    <dbReference type="GeneID" id="9674961"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_96380"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_96380"/>
    <dbReference type="eggNOG" id="KOG1191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019624_3_0_1"/>
    <dbReference type="InParanoid" id="C7YUS8"/>
    <dbReference type="OMA" id="VQIGFHI"/>
    <dbReference type="OrthoDB" id="188276at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="entry name" value="tRNA modification GTPase MnmE domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714:SF2">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116878">
        <property type="entry name" value="TrmE connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP-binding protein TrmE N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="MnmE helical" evidence="3">
        <location>
            <begin position="56"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="1">
        <location>
            <begin position="155"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU44463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="47629" checksum="CE2EBC137134D06C" modified="2009-10-13" version="1">MLRRSLHVLELHVHGGAATVKAVLSAIPRCSTAQRIRYAEPGEFTKRAFFNDRLDLAQIESLSDTLAAETEQQRRAAVRGNSGALGRQYEAWREQLLLARGEIEALIDFSEDQHFDESQADLLHNVTTQVARMLHSIELHEQGSQRSELLRNGIRIALLGPPNVGKSSLMNLIVGREASIVSGEAGTTRDIIEASLDIRGYLCSFADTAGFRSNGSGTINGDGGGAIGAVEEEGIRRAKQKAMDSDLVIVLASVEDGPGGSFLQYDEETLDLAAGAEDCLIVVNKRDAVDAGQFEKLVEEFRRTVSEKAPKLAAAELVSISCKEAQTLGSESKDPGGVQAVMDQLVGSFEKMTSMPVDLQDLLGVTERQRQLLVKCRGHLQDFMAEATPEEEGMDADTVLAAEYLRYAADCLARITGRGEFGDVEDVLGVIFEKFCVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVL8</accession>
    <name>C7YVL8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_29730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="FEBS J." volume="281" first="2240" last="2253">
            <title>The substrate specificity, enantioselectivity and structure of the (R)-selective amine : pyruvate transaminase from Nectria haematococca.</title>
            <authorList>
                <person name="Sayer C."/>
                <person name="Martinez-Torres R.J."/>
                <person name="Richter N."/>
                <person name="Isupov M.N."/>
                <person name="Hailes H.C."/>
                <person name="Littlechild J.A."/>
                <person name="Ward J.M."/>
            </authorList>
            <dbReference type="PubMed" id="24618038"/>
            <dbReference type="DOI" id="10.1111/febs.12778"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) IN COMPLEX WITH PYRIDOXAL 5'-PHOSPHATE</scope>
        <scope>PYRIDOXAL PHOSPHATE AT LYS-179</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049732.1">
        <property type="nucleotide sequence ID" value="XM_003049686.1"/>
    </dbReference>
    <dbReference type="PDB" id="4CMD">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.68 A"/>
        <property type="chains" value="A/B=1-320"/>
    </dbReference>
    <dbReference type="PDB" id="4CMF">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.50 A"/>
        <property type="chains" value="A=1-320"/>
    </dbReference>
    <dbReference type="PDBsum" id="4CMD"/>
    <dbReference type="PDBsum" id="4CMF"/>
    <dbReference type="AlphaFoldDB" id="C7YVL8"/>
    <dbReference type="SMR" id="C7YVL8"/>
    <dbReference type="MINT" id="C7YVL8"/>
    <dbReference type="STRING" id="660122.C7YVL8"/>
    <dbReference type="GeneID" id="9677307"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_29730"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_29730"/>
    <dbReference type="eggNOG" id="KOG0975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020844_4_1_1"/>
    <dbReference type="InParanoid" id="C7YVL8"/>
    <dbReference type="OMA" id="WRGSEMM"/>
    <dbReference type="OrthoDB" id="25921at2759"/>
    <dbReference type="EvolutionaryTrace" id="C7YVL8"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000002">
        <property type="entry name" value="D-alanine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050571">
        <property type="entry name" value="Class-IV_PLP-Dep_Aminotrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42743">
        <property type="entry name" value="AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42743:SF11">
        <property type="entry name" value="AMINODEOXYCHORISMATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 7" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine (covalent)" evidence="6">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU44019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="4CMD"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="4CMF"/>
        </source>
    </evidence>
    <sequence length="320" mass="35978" checksum="248B98DFB817C0E0" modified="2009-10-13" version="1">MATMDKVFAGYAERQAVLEASKNPLAKGVAWIQGELVPLHEARIPLLDQGFMHSDLTYDVPSVWDGRFFRLEDHLNRLEASCKKMRLRMPLPREEVIKTLVDMVAKSGIRDAFVELIVTRGLTGVRGAKPEELLNNNLYMFIQPYVWVMDPDVQYTGGRAIVARTVRRVPPGSIDPTIKNLQWGDLVRGLFEANDRGATYPFLTDGDANLTEGSGFNVVLIKDGVLYTPDRGVLQGITRKSVIDAARSCGYEIRVEHVPIEATYQADEILMCTTAGGIMPITTLDDKPVKDGKVGPITKAIWDRYWAMHWEDEFSFKINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVZ1</accession>
    <name>C7YVZ1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_74125</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049797.1">
        <property type="nucleotide sequence ID" value="XM_003049751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVZ1"/>
    <dbReference type="FunCoup" id="C7YVZ1">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="GeneID" id="9677162"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74125"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74125"/>
    <dbReference type="eggNOG" id="ENOG502QT05">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036005_0_0_1"/>
    <dbReference type="InParanoid" id="C7YVZ1"/>
    <dbReference type="OMA" id="YENAWHS"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="97"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU44084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="380" mass="42667" checksum="4BFAEBE3B6A3C0AB" modified="2009-10-13" version="1">MAPSATTTTASLVTDASKLKLYPGHVEGVYKELSPVVYKKDDELKGTDDFAAAKYPNYLPTWNKDQVYPPLVPFEHYDHGRDADPTFPNLITKDAKVSHLTPTIGTEVEGVQLSQLSKAGKDELARYVAERKVVAFRNQDFADLPISEALEFGGYFGRHHIHPTSGSPEGHPEIHLVHRGAGDKSHETFFKTRVSSVAWHSDITYEQQPPGTTFLYILDTPDTGGDTLFANTVEAYERLSPAFQKLLHGLKATHSGIEQVNASVKKGSIKRREPVVNEHPIVRTHPVTGEKSLFVNPQFTRDIVGLKKEESDAILNFLYEHIAWGADFHARVKWQEKTVVVWDNRSVQHTALVDWKSGQRRHLARITPQAERPYETPFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWB7</accession>
    <name>C7YWB7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_89757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049864.1">
        <property type="nucleotide sequence ID" value="XM_003049818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWB7"/>
    <dbReference type="STRING" id="660122.C7YWB7"/>
    <dbReference type="GeneID" id="9677221"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89757"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89757"/>
    <dbReference type="eggNOG" id="ENOG502SE67">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050915_0_0_1"/>
    <dbReference type="InParanoid" id="C7YWB7"/>
    <dbReference type="OMA" id="QNTSTEC"/>
    <dbReference type="OrthoDB" id="5296155at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU44151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="40328" checksum="25D8D07AAB25B518" modified="2009-10-13" version="1">MIRGHGRGPGSLGSRSGVSYMPPIDENEVASTPSPSPPKTPLRVPQKSPRRGMRTHNGLNGVLPPPYVPPYILSAGYSPPHVPPTLHPPPPSYKEAHAVKGKLVEGDSLGEEEGVVPRGRICGVDRRRVCCLFGVAVAIMAIIAIGLGIGLTVGLKDKRQDSTEDNSPLKDPNFPAGSFSFKANLQKPSAECTSNPSTWRCYPYTEGEPATFFWIITYVNTQFYKISSTDNPFAPSFTNLTLELLDENTPKERLLFSFSMNKTVVPDNQLSSSNRAARCTFDDTRFEATLWTHKSKGHNNDDDKSDNSNFVAWPGDVEVVQSKSFKSGSPRCVDEDDDKVGDVKSRSGAFHHALFTARRQHYMNYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXF3</accession>
    <name>C7YXF3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SRT2101</name>
        <name evidence="7" type="ORF">NECHADRAFT_94915</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049292.1">
        <property type="nucleotide sequence ID" value="XM_003049246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXF3"/>
    <dbReference type="STRING" id="660122.C7YXF3"/>
    <dbReference type="GeneID" id="9666273"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94915"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94915"/>
    <dbReference type="eggNOG" id="KOG2684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023643_3_1_1"/>
    <dbReference type="InParanoid" id="C7YXF3"/>
    <dbReference type="OMA" id="KWIAAGP"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="6">
        <location>
            <begin position="5"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU43579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="354" mass="38264" checksum="77F83E7737AC9F76" modified="2009-10-13" version="1">MADSTNLDPAAVADFHDTLKKSKRIIAVIGAGLSASSGLAVFRGTSGLWKSQDVTQVASPAGFRHDPGLVWQFYSYRRQEALGAKPNPAHYALAELARQVPGFVALTQNVDNLSPRAGHPPGQMKELHGNLFTLSCIDKIGCGYVERDNFEECLTPALDPSKDEKETMGSIDPDNKPRASPLLLAGIARKHAQILGDKYEGNAPTTRDLAALKHPEDAAADPVAQVRLSSGLTKEDLPQCPKCKANILRPDVVWFGEPLPLQVVNETEALFEDPEPIDLCLNIGTSNRVWPAAGYAAMARDKGARVAYINTRAEDAKSVVPGRDWIFVSDAAVVLPELLKPIIGESREWDGKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXJ1</accession>
    <name>C7YXJ1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AttH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_82547</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049063.1">
        <property type="nucleotide sequence ID" value="XM_003049017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXJ1"/>
    <dbReference type="GeneID" id="9676955"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82547"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82547"/>
    <dbReference type="eggNOG" id="ENOG502SMYB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051719_1_0_1"/>
    <dbReference type="InParanoid" id="C7YXJ1"/>
    <dbReference type="OMA" id="GIGYHDK"/>
    <dbReference type="OrthoDB" id="5344254at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057722">
        <property type="entry name" value="AsqO/PenF-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056402">
        <property type="entry name" value="DA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25581">
        <property type="entry name" value="AsqO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24137">
        <property type="entry name" value="DA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159245">
        <property type="entry name" value="AttH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988766" description="AttH domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Diels-Alderase N-terminal" evidence="2">
        <location>
            <begin position="24"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="AsqO/PenF-like C-terminal" evidence="3">
        <location>
            <begin position="240"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU43350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="42014" checksum="43C7AB19F31A8053" modified="2009-10-13" version="1">MAMFVKFAAFAAMSGLALAAPEKTTIRHLQLKPEYYNGTISVEHLSVPENLDGFKMSTPAARKSADFWYFDVFSKATNQTLNIVFFNSGEFKQYPHPLSVQVSGVFPNGTDFYYEALADEGVSITNSPQGIQGEWGGIGSFKGSSLEKPNVEYSIKLDSPDMGISGKIKFKSMTPAHYPCDLYGAIGVTQNLLPGLYWANAVPDAETVVDLKVKDTAIQFKDGVGYHDKNWGNQSIIDGPKYWDWGHGRFGPYSVVWYNLLDYEGKETRRSFVVKDRKVLMVSCDPKSMEVRQKGGKAAWPPTTGLLETDGLSIHYTLPDGQELNVDVTTEIIVRDESGAYQRANGIIKGGIKGKETFKGKAHYEEFIFGIVNDYTPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXQ1</accession>
    <name>C7YXQ1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyl transferase 64 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_45533</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049095.1">
        <property type="nucleotide sequence ID" value="XM_003049049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXQ1"/>
    <dbReference type="STRING" id="660122.C7YXQ1"/>
    <dbReference type="GeneID" id="9666395"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45533"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45533"/>
    <dbReference type="eggNOG" id="KOG2264">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051555_0_0_1"/>
    <dbReference type="InParanoid" id="C7YXQ1"/>
    <dbReference type="OMA" id="WIYTIHP"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015338">
        <property type="entry name" value="GT64_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261">
        <property type="entry name" value="ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261:SF2">
        <property type="entry name" value="ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09258">
        <property type="entry name" value="Glyco_transf_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase 64" evidence="5">
        <location>
            <begin position="60"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU43382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="307" mass="35431" checksum="B4629EA9C5074553" modified="2009-10-13" version="1">MLHQYSESLPQITWRPYTAPQNGWGIELDTPVCAEAQSIVSEDIWLESRRKYQHLRDDKFTLVISTYKRPDSLNATLTLVLSEEIPTLHEIVVVWNEVNTTAPTDFISDYGVRVRFRVSPRNSLNMKLWNDPKIRTQGILLSDDDCHYEPDDMGFIFNYWKEHAQDRIVGAFPRAYTIGEDGQYKYSFARGWDRYSMVLTGLAFAHISFLDYYSSDDPLMTDIRNLIDEKFNCEDIALNFIVSMLTCNSPLQVVGLKHPINAGGKHGISTKKGHIGKRHSCVNDFANMMGYMPLRNATHYIHRGRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXQ7</accession>
    <name>C7YXQ7_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_27878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049100.1">
        <property type="nucleotide sequence ID" value="XM_003049054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXQ7"/>
    <dbReference type="GeneID" id="9676992"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_27878"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_27878"/>
    <dbReference type="eggNOG" id="ENOG502S6I6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036419_1_0_1"/>
    <dbReference type="InParanoid" id="C7YXQ7"/>
    <dbReference type="OMA" id="LERWIYV"/>
    <dbReference type="OrthoDB" id="10025998at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU43387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="246" mass="28161" checksum="AA6AEF3151C1BF99" modified="2009-10-13" version="1" fragment="single">ILERKNAPGLYIVIKATIGPPIINLINEASTTASLNMISWNKAYSLLPIPTIVRHKFYPLTPFNSALGQTLRRHAKLGWTTRDMLWPDQTKKFMTGNECRRIGGTRSLVINLRDVPPGDYTPDHVLDRSVFSVVWESSGDSRRVSASIQPGVEFTALRDVYANGRRGQGCKAWEKFLRGKLERWIFVEIAKMSQQQRPPGFYFMAPSNYRVSIPSGYQVPDTWDYADDQIIPWFQEWDSTEGNSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXS2</accession>
    <name>C7YXS2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_45342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049107.1">
        <property type="nucleotide sequence ID" value="XM_003049061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXS2"/>
    <dbReference type="STRING" id="660122.C7YXS2"/>
    <dbReference type="GeneID" id="9666404"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45342"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45342"/>
    <dbReference type="eggNOG" id="KOG3968">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012358_2_3_1"/>
    <dbReference type="InParanoid" id="C7YXS2"/>
    <dbReference type="OMA" id="HMWQTAM"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050287">
        <property type="entry name" value="MTA/SAH_deaminase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006056">
        <property type="entry name" value="PRK08204.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794:SF11">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794">
        <property type="entry name" value="AMINOHYDROLASE SSNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="71"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU43394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="485" mass="52311" checksum="8007BBF0A0B19CDF" modified="2009-10-13" version="1">MASTETSTARVSGQTDFILIKGATIITVNDEEDILEDCDILIQGDRIAALGKNLSQPEGLTGEVIDGTDSIVIPGFVDGHHHMWQQMLRGVATDWSLLDYMISMRSVYGSLFTPEDVYLSTYVGALSLLNNGITSVLDHCHIINSPDHADAAVKALKDAGIRGTFCYGFYANPPVDDSGASSTTPEFSHSERLADAARIREKYFGDNHPGRQLLTFGVAPNEVEVQDFDDTAREIAEARGLGARIVTMHVAHGPMDLLHKETVQKLADAGALKSDLVFAHGASFTDSELREICTSGAGVVSTPDTELQMGMGFPVAFRARDGGCRAGLGIDITSNQGNDFIAQMRLALQTQRAVENEKRVPVTVSRKTSEVLRMATIGGAEVMRIDDLVGSLVVGMKADVVMIKCNDIESSPVSSATGAVVFNASVGHIDTVIVDGQVKKRNGKLVADWEPLRDEMRRRATAIKTKAAGHDLEAARERWMGPVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7YY39</accession>
    <name>C7YY39_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_95012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049158.1">
        <property type="nucleotide sequence ID" value="XM_003049112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YY39"/>
    <dbReference type="GeneID" id="9677050"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95012"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95012"/>
    <dbReference type="eggNOG" id="ENOG502S3ED">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1489067_0_0_1"/>
    <dbReference type="InParanoid" id="C7YY39"/>
    <dbReference type="OMA" id="RWHPSND"/>
    <dbReference type="OrthoDB" id="3525185at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF13">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU43445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="181" mass="20432" checksum="5396E0FE9C78ACB8" modified="2009-10-13" version="1">MVNYGVSRGCDTCKKRRKKCDESRPSCQRCLKSRRVCPGYKDDGLLVFRHYQPVDNLSTLQFDRWSPKTDVLLEEVALDIFLDSFVVPSHDRGQSRGFLDGMHSLLANANPACTLISAARVITLASIANRTRWHSLLETAQKRYGQLLMDFTVSLSQEKAGVSFKYFLTAVLLGLYEVSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYE6</accession>
    <name>C7YYE6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_95436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048886.1">
        <property type="nucleotide sequence ID" value="XM_003048840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYE6"/>
    <dbReference type="STRING" id="660122.C7YYE6"/>
    <dbReference type="GeneID" id="9665479"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95436"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95436"/>
    <dbReference type="eggNOG" id="ENOG502QTVK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033074_2_0_1"/>
    <dbReference type="InParanoid" id="C7YYE6"/>
    <dbReference type="OMA" id="EPLAHIC"/>
    <dbReference type="OrthoDB" id="5317787at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU43173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="513" mass="57191" checksum="D4EA0D5C43225681" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z026</accession>
    <name>C7Z026_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_84227</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048610.1">
        <property type="nucleotide sequence ID" value="XM_003048564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z026"/>
    <dbReference type="STRING" id="660122.C7Z026"/>
    <dbReference type="GeneID" id="9667687"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84227"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84227"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_34_7_1"/>
    <dbReference type="InParanoid" id="C7Z026"/>
    <dbReference type="OMA" id="EWISPVP"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DUF7708" evidence="4">
        <location>
            <begin position="146"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="351"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="860"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1147"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU42897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1272" mass="141065" checksum="F893C8C459D882E6" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0H3</accession>
    <name>C7Z0H3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Arginase</fullName>
            <ecNumber evidence="2 11">3.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_60667</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>L-arginine + H2O = urea + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:20569"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="EC" id="3.5.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.1" evidence="2 11"/>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047915.1">
        <property type="nucleotide sequence ID" value="XM_003047869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0H3"/>
    <dbReference type="FunCoup" id="C7Z0H3">
        <property type="interactions" value="1350"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z0H3"/>
    <dbReference type="GeneID" id="9667267"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_60667"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_60667"/>
    <dbReference type="eggNOG" id="KOG2965">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039478_6_1_1"/>
    <dbReference type="InParanoid" id="C7Z0H3"/>
    <dbReference type="OMA" id="YKEFRYA"/>
    <dbReference type="OrthoDB" id="9992747at2759"/>
    <dbReference type="UniPathway" id="UPA00158">
        <property type="reaction ID" value="UER00270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09989">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000009">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014033">
        <property type="entry name" value="Arginase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01229">
        <property type="entry name" value="rocF_arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782:SF3">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU42202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="325" mass="35259" checksum="1D6D85C8A988B870" modified="2009-10-13" version="1">MNTGLIDSRFLSKPEELGVVAVGFSGGQPKAGVDDGPSALIEAGLLSEIREELGYKIFGDETVQQFDDIVPESDPDYRGMKKARHASAVTRKIASQTYEHSREGRMTLTLGGDHSIAIGTIAGTAKATRERLNREIAVIWVDAHSDINTPESSDSGNIHGMPVAFLTGLAKDDNEEYFGWLEDDMRLSVKKLVYIGLRSVDVGERKILREHGIKAYSMHDVDRHGIGRVVEMALAHIGNDTPIHLSFDVDALDPMWAPSTGTPVRGGLTLREGDYICEAVHQTGNLVAVDLVEVNPKLADGKQAEQDTIRAGCSLVRCALGDTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0M5</accession>
    <name>C7Z0M5_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_40200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047940.1">
        <property type="nucleotide sequence ID" value="XM_003047894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0M5"/>
    <dbReference type="STRING" id="660122.C7Z0M5"/>
    <dbReference type="GeneID" id="9671925"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_40200"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_40200"/>
    <dbReference type="eggNOG" id="ENOG502SX1S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072359_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z0M5"/>
    <dbReference type="OMA" id="ANAQIPF"/>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="238" mass="25586" checksum="6C76BECBA4BE6A6F" modified="2009-10-13" version="1">MSGGWNPVSGRDASGARPAFAPVGAPMPTPGEPYIPHYGGPAPQYHGYVTYTGGIPYSHLAPPAYPMQPPMGGLYAQKTFAYQPNGTGNVPRQPQPHPAIDTNMPAAQMTNSSGGVGCEPGYNYFFPAEHAKMHVFKSKTPPWQLPENTRIPFIASHVPCGTKLGDLLKGFGCTNPVPKKNLCFEVYAGGNGKWYKGFCFAGDEKEQLKKTIKDVGWGPDRTGEPGAKPIVCLWFCKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1E3</accession>
    <name>C7Z1E3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_50836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU41989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047702.1">
        <property type="nucleotide sequence ID" value="XM_003047656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1E3"/>
    <dbReference type="GeneID" id="9671654"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_50836"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_50836"/>
    <dbReference type="eggNOG" id="ENOG502S01H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069193_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z1E3"/>
    <dbReference type="OMA" id="ILNCHYG"/>
    <dbReference type="OrthoDB" id="5392202at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052999">
        <property type="entry name" value="PTS1_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180">
        <property type="entry name" value="CONSERVED MITOCHONDRIAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180:SF2">
        <property type="entry name" value="PEROXISOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU41989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="30556" checksum="609414A29697D5E3" modified="2009-10-13" version="1">MSKLSAPLKALINAPFARPGPRPAPQQVQELYESIANDAAVRNLGIRSWLTVSAAATFTLNSPDSLPVLHRVASSKQPDSAVQNAEFIREVGLKCIGFNGIPRTINSLNSFYASLPKDVASKLSTTPSRQPTPENLETTLKRGRGLWDSVYRPFEDKLLEKLALAHPDLPVHILSSHYAALFTDPPPAERGSLASIGRVHTSLLGISCLRAQTGVGPQVLSHVFGLRKALEDGTYKNDIDGETEEGVQYLTSDEGGHWILNTVDKIVEAIGGSSFAPGRESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1U6</accession>
    <name>C7Z1U6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_96892</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU41885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047598.1">
        <property type="nucleotide sequence ID" value="XM_003047552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1U6"/>
    <dbReference type="FunCoup" id="C7Z1U6">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="GeneID" id="9671561"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_96892"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_96892"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_0_1"/>
    <dbReference type="InParanoid" id="C7Z1U6"/>
    <dbReference type="OMA" id="MFINGWN"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF189">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="38"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU41885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="561" mass="60795" checksum="6CAD6E2F606732FC" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z285</accession>
    <name>C7Z285_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_86062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU42129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047842.1">
        <property type="nucleotide sequence ID" value="XM_003047796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z285"/>
    <dbReference type="GeneID" id="9671806"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86062"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86062"/>
    <dbReference type="HOGENOM" id="CLU_2027324_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z285"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="122" mass="13305" checksum="4659EAE325104CF3" modified="2009-10-13" version="1">MCVSSFSVVGVHGKRPDSGDVVMFCIGGEDDSIKDPCIPDRSIVNLETEGISDTSMLIRRRVARHIPLYRTQRVERVTQTGQASSNTSSPSLSDIIGECSRQHQPADRGYLWGSSGSHSRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z3T9</accession>
    <name>C7Z3T9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_16313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046908.1">
        <property type="nucleotide sequence ID" value="XM_003046862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z3T9"/>
    <dbReference type="GeneID" id="9675490"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_16313"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_16313"/>
    <dbReference type="eggNOG" id="ENOG502S3V7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038504_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z3T9"/>
    <dbReference type="OMA" id="RVEIMKC"/>
    <dbReference type="OrthoDB" id="5593235at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU41195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="341" mass="39932" checksum="F510CFD7019313A8" modified="2009-10-13" version="1" fragment="single">PNVPVKPNVTVSGLVFYGRKSRVESMRCYIERNLVDNGGWLDEVLWVVNTENQDDLFYLDEIVASNPIRHKLLIPEEHLGTYTYWKAWQHLERDKYYVKIDDDILWIEDGAIPKLVSHKIENPDTFVVSGNIINNPPLGFMHYRMGALHPYLPELEKPDQITNASDFWKPSKHPFWNGPNDTVWNPMRPPPEHENVRWLRVEDEKMMWQTPAHQLTYDVWGDSYKSWAIASQMHYSLFENIEKDTLDLYKFEKPWTMHGDRIRINFMCVYANDILDNGVGSWPGNRGDEDMIVLDLPNALRRPVVILGSALASHFQYMDQPDLEKTDILSRYRSLAQDRAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z3Z0</accession>
    <name>C7Z3Z0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Corticosteroid-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_83418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047101.1">
        <property type="nucleotide sequence ID" value="XM_003047055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z3Z0"/>
    <dbReference type="GeneID" id="9678677"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83418"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83418"/>
    <dbReference type="eggNOG" id="ENOG502RS6C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063083_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z3Z0"/>
    <dbReference type="OMA" id="QCHSHAR"/>
    <dbReference type="OrthoDB" id="2281895at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU41388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="39225" checksum="138365F4FC92B55C" modified="2009-10-13" version="1">MPWKAPIHHFSYRYLIIPPILLALATIIALFIHSDVNAALLWSQCHSRARLPGLSRIPGIGTPLCYVVSFFRAAMHSVRSSAVMAVVLAFVGGLLTVSSVEAARICNAPNVLIAYPTGPWLVFDLVGGAVVWELVIIPAFLHRARSVIVEQERRDEDGESRDVTSRHLPDSELVAIPVSVALGYFLPSLFMFFFTSPVSIGIWLFFPIYVSLIRQATRKIVNLVKRADPTTIHLASSRLSLIFVYALPVVCSILAHILVIWSLTLPDDRKEMTKSTIVFIEVDTQFIFWTVLYWMLVEVGWKVPLTTLVTAILVGPGAGTCIGWIYREKLIHDHEEASEDAEPADEETPLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z3Z5</accession>
    <name>C7Z3Z5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_62578</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046939.1">
        <property type="nucleotide sequence ID" value="XM_003046893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z3Z5"/>
    <dbReference type="FunCoup" id="C7Z3Z5">
        <property type="interactions" value="601"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z3Z5"/>
    <dbReference type="GeneID" id="9675590"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_62578"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_62578"/>
    <dbReference type="eggNOG" id="KOG0937">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026996_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z3Z5"/>
    <dbReference type="OMA" id="KPLIWCD"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09250">
        <property type="entry name" value="AP-1_Mu1_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14835">
        <property type="entry name" value="AP1_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000006">
        <property type="entry name" value="AP-1 complex subunit mu-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="8">
        <location>
            <begin position="167"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU41226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="431" mass="49194" checksum="59BB8131D499040F" modified="2009-10-13" version="1">MASALFFLDLKGKTLLARNYRGDIPMSAVEKFPVLLSEAEEDSSAVPPCFSHEGINYLYIRHNNLYLLALTKRNTNAAEILLFLHKIVEVFTEYFKALEEESIRDNFVIIYELLDEMMDFGYPQTTESKILQEYITQESHKLEIQARPPIAVTNAVSWRSEGIRYRKNEVFLDVVESLNLLVSANGNVLRSEILGAIKMKCYLSGMPELRLGLNDKVMFETTGRATRGKAIEMEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTQVKPLIWVECVVESHSGSRIEYMLKARAQFKRRSTANNVEIVVPVPDDADSPRFRTNIGSVHYAPEQSAIVWKIKQFGGGKEFLMRAELGLPSVRGDDEQGGKGAKRPIQVKFEIPYFTTSGIQVRYLKITEPKLQYPSLPWVRYITQSGDIAVRLPDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z408</accession>
    <name>C7Z408_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_101197</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047111.1">
        <property type="nucleotide sequence ID" value="XM_003047065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z408"/>
    <dbReference type="STRING" id="660122.C7Z408"/>
    <dbReference type="GeneID" id="9675596"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101197"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101197"/>
    <dbReference type="eggNOG" id="ENOG502SWBD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043982_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z408"/>
    <dbReference type="OMA" id="TLYWACT"/>
    <dbReference type="OrthoDB" id="4737775at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008974">
        <property type="term" value="F:phosphoribulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006082">
        <property type="entry name" value="PRK"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00567">
        <property type="entry name" value="PHOSPHORIBULOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU41398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="40456" checksum="025A028F850FF815" modified="2009-10-13" version="1">MSPSNSSRDTPDPKRERSRIAQREYRKRHASKFSTLKDENRKLRNAIKKIDQVASRRARHDKDLQAALAEAREVAGIEEDDSSALTRVLSPSQRTISPARQASTGVMFTAQPAFFSVANGRNHLNVQSLGLPQQVWLDTDRLVRIYEAPMDAAQYLGDNLLTFAGALYWACTKNTVSLWQAKQLALMGKAARPESNLDRLFNHSKHLRDHDFLVSLALARLEYHQKGYTHLPPTATQAQWDQVVPDLSKKIERDYAERGETLEWWKTPREVEQFVKRHLEPEEVVELQALIEGRGTGASLAKYTPLVEALVQSFVCFGDGPRWNILWVSMMVGGWRTHQEDEARARAQQSQAQTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z439</accession>
    <name>C7Z439_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_46227</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046965.1">
        <property type="nucleotide sequence ID" value="XM_003046919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z439"/>
    <dbReference type="GeneID" id="9675608"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_46227"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_46227"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002406_3_1_1"/>
    <dbReference type="InParanoid" id="C7Z439"/>
    <dbReference type="OMA" id="NHIYTHQ"/>
    <dbReference type="OrthoDB" id="21416at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="862"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="890"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU41252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="916" mass="107026" checksum="F34E2B8096BA5548" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4D9</accession>
    <name>C7Z4D9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reticulon-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_103454</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Endoplasmic reticulum membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="ENOG502SDVP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046578_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z4D9"/>
    <dbReference type="OMA" id="TGLMKQY"/>
    <dbReference type="OrthoDB" id="567788at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003388">
        <property type="entry name" value="Reticulon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02453">
        <property type="entry name" value="Reticulon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50845">
        <property type="entry name" value="RETICULON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Reticulon" evidence="8">
        <location>
            <begin position="75"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="279"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU40904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="356" mass="38575" checksum="40418BAE747C5AB3" modified="2009-10-13" version="1">MADSAPAVNGGSLLEATKSNAAAAYQSVTNGPVAQNVYDHTQKASNEFSNLAAARRTPSTPAATGQPLTHYHSFFSELLSWNNPRASGIAYATTVSLIFAARYLDVLRWAFKVSWMVLGVTILAEVVGKVVLNNGLATQVRPRRYYTVPRETLDHMIGDAHELVNFFVIEAQRIIFAENVFASAAAFVAAFISYYLVKLVPYWGLAVIGTTVVFFVPLIYTSNQELIDEQLHHASELINSQTAQVRDVASKQMEQVSAIGKQYAGDYSGKVHDLLRGNHGSRQKIEKPTKGAAPVVKEPEFPSPPTEDPVKSEAAPQIPTPAALKEEISEPTAIDAAIPEVPSEPVVANKEPMIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z544</accession>
    <name>C7Z544_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rtm1p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_66702</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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            <taxon>Fusarium vanettenii</taxon>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046169.1">
        <property type="nucleotide sequence ID" value="XM_003046123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z544"/>
    <dbReference type="GeneID" id="9678554"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_66702"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_66702"/>
    <dbReference type="eggNOG" id="ENOG502QURG">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033465_3_0_1"/>
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    <dbReference type="OMA" id="RHEWPLY"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF32">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU40456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="31448" checksum="3C0B480F69211748" modified="2009-10-13" version="1">MADKESIWMYNPSFALAIIGTIVYSIIFLVISYLTLIKYRAWFFIVVVIGSAIEVAAYVLRAYSAKNQSEIGPFVNTLTFTVLAPVFIAAGNYLLISRLILAVLPPSRHRILKIPGRRLTPIFVACDVVAFLVQGSGSGIASSDNWQGQMEKIGRNILIGGLAFQLVAFSLFLCVFRRFHVLANRMAVDGAPNGWQKVVLAVYVSSCLIMVRCIYRVCEFAEGMNGYAFRNEWLFWVFESLPMIGAIGIFCIYHPSRYLGRDGARRKAVGSQDSVEFVERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z5B4</accession>
    <name>C7Z5B4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_122368</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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            <taxon>Fusarium solani species complex</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU41069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046782.1">
        <property type="nucleotide sequence ID" value="XM_003046736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z5B4"/>
    <dbReference type="STRING" id="660122.C7Z5B4"/>
    <dbReference type="GeneID" id="9678587"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_122368"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_122368"/>
    <dbReference type="HOGENOM" id="CLU_1354951_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z5B4"/>
    <dbReference type="OrthoDB" id="5096701at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002986801" description="LysM domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU41069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="21978" checksum="46302C3B336FEDD7" modified="2009-10-13" version="1">MVGIVQFTAAVAAVAGVASAATPIQLSHPHCDQFVYGQSCQEFTSRFGLSQQAFLNLNPNLNPTTGCNQLPPSWYCVRTRAPGAPISTPYPASTAMFGNCAKFAAGFKTQGGSCWDIAAAFELSQPDWRWLNPDVPFSDGWKCFSLINDHYCVELKQETPPPPITSTTTTTTTKPATTTTKRKTTTTKRRTTSTRGPRLHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z5C1</accession>
    <name>C7Z5C1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SRT2106</name>
        <name evidence="8" type="ORF">NECHADRAFT_105923</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC16 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU41072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046785.1">
        <property type="nucleotide sequence ID" value="XM_003046739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z5C1"/>
    <dbReference type="STRING" id="660122.C7Z5C1"/>
    <dbReference type="GeneID" id="9678316"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_105923"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_105923"/>
    <dbReference type="eggNOG" id="KOG2684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2990">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_374350_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z5C1"/>
    <dbReference type="OrthoDB" id="360327at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036054">
        <property type="term" value="F:protein-malonyllysine demalonylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036055">
        <property type="term" value="F:protein-succinyllysine desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01412">
        <property type="entry name" value="SIRT5_Af1_CobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027546">
        <property type="entry name" value="Sirtuin_class_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF2">
        <property type="entry name" value="SPLICING FACTOR YJU2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="511"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="570"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="577"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU41072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="676" mass="74723" checksum="5211BF655F393F32" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6R4</accession>
    <name>C7Z6R4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Clathrin/coatomer adaptor adaptin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_34112</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045889.1">
        <property type="nucleotide sequence ID" value="XM_003045843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6R4"/>
    <dbReference type="FunCoup" id="C7Z6R4">
        <property type="interactions" value="449"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z6R4"/>
    <dbReference type="GeneID" id="9668088"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_34112"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_34112"/>
    <dbReference type="eggNOG" id="KOG1060">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006320_3_2_1"/>
    <dbReference type="InParanoid" id="C7Z6R4"/>
    <dbReference type="OMA" id="HFLVRST"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="7">
        <location>
            <begin position="38"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="253"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="650"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="257"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="660"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="720"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU40176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="777" mass="86513" checksum="BA75217E207E10F4" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z748</accession>
    <name>C7Z748_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ysc84 actin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_66301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
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                <person name="Kroken S."/>
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</entry>
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                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
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                <person name="Salamov A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="53233" checksum="F17ACC3CEA648F40" modified="2009-10-13" version="1">MADTATAPAPAADKQAHTRPTKPDENAFKEALAKAEKDHKVSMDQLAAVKAKIEIAMPNKNKDQPSPTQKRRQELIAQANEIRQKQAGGKNARTTKLDQIKRLDEQVRSRIAEQKTAKAKVPYKSLEDVDRQIATLDKQVNSGTMKLVDEKKALSDISSLRKIRKNFGQFEDSQKQIDDLRAKIKEIKDTMDDPEQKAMSEQYTKIQTELDAIKAEQDEAYKGLSSLRDERTRLQAEQQEKYTAIRKLKDDYYGQKKAFQAYEREARERYREKQRAEHERHIQERKKAEAERRLGDASDPAYLDEIRRANSLLQFLDPNHKVEKGPLMADTGLGAQAQRSVDEAGLKGTKLVRKEDREDEYFSAVKKGKKGKKGGHAASSKFFNVPPSVVEDCAAMGIDPPMSALDIPGVTEKVRAKLDFWKNDQEAQTKRNIEKAKKEIAELEAAEANGEKVEEVTSGLKETSIAEKQES</sequence>
</entry>
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        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
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                <person name="Grimwood J."/>
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                <person name="Freitag M."/>
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                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
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                <person name="Napoli C.A."/>
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        <property type="match status" value="1"/>
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            <begin position="705"/>
            <end position="758"/>
        </location>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="792"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU40316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="828" mass="91554" checksum="48231F1222E843AB" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7T5</accession>
    <name>C7Z7T5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_39621</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045596.1">
        <property type="nucleotide sequence ID" value="XM_003045550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7T5"/>
    <dbReference type="GeneID" id="9672596"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_39621"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_39621"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="C7Z7T5"/>
    <dbReference type="OMA" id="CYIVQPV"/>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF52">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G11820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="45"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU39883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="491" mass="55084" checksum="3AFC925345080D24" modified="2009-10-13" version="1">MSVVEEKTPTVADESHPPGTPKSEDYAPIDPVAEKKLLRKLDLCIYPTLFIIYMMSFLDRINISNARIQGLPQEIDLSGNRFNIALFVYFIPYILLEVPSNMIIRKVRPSFYLSALMFCWGIINMCMGFVHSYGSLVALRFLLGAFEAGVLPGIIYVTSMYYKRHEFQKRMSFFFTSTLIGGAFGGLLAYGIARLGGDKGMSAWRWIFIIEGAITAFLSIIAVFLIADWPEQARFLTAEEKALVQRRLAADTGDSCRMDTLNKFATKRILKDWKIWLGAFMYMGIGTTGYAGVFFMPTILLEFGWKAEEAQVQTIPVYVLSAGVMLLSAWGSDRLKHRYGFVLTGACIATIGYAMLLEQGGKSRDYKFAAVFLINAGGYIATPICLAWLQNNLSGHWKRSFGSALQVTLGNVAGIIGANIFLVKESPTYKTGYGTALGMMWMGTLAATLMFGFMWRENRKRDAGDRDDRLSLPEEDLRNMGDWHPSFRFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z875</accession>
    <name>C7Z875_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_93121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045530.1">
        <property type="nucleotide sequence ID" value="XM_003045484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z875"/>
    <dbReference type="FunCoup" id="C7Z875">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="GeneID" id="9672565"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_93121"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_93121"/>
    <dbReference type="eggNOG" id="ENOG502S62B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044999_1_1_1"/>
    <dbReference type="InParanoid" id="C7Z875"/>
    <dbReference type="OMA" id="IMSTAGR"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="283" mass="31459" checksum="6B111977601D764E" modified="2009-10-13" version="1">MTVRALVVGGTSGIGYAMACRVASEASTSIVTISGRTKPQNIPHANITFRPLEATSMRQIKQYTDDFKAQGQKLDLLIMTQGIMTMAGRTETPEGIDRKMALHYYGKQLLIRELLPVMNEDSKVIIVFDGWLGSPDKLIWEDLDLKTHYSLGKAADHCMSMNDAMVQYYAAQQKSTGVGRRHFAHAWPGGVSSGLWRELPWYLRTVGRVGANLVCVSAETCAEYLMNGVTERCAEGEKEGRYWSNIDNKGRLLVKKAIWTEGQMKKVADHTWGLIDGALNVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8H3</accession>
    <name>C7Z8H3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_70017</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU38938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044651.1">
        <property type="nucleotide sequence ID" value="XM_003044605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8H3"/>
    <dbReference type="FunCoup" id="C7Z8H3">
        <property type="interactions" value="293"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z8H3"/>
    <dbReference type="GeneID" id="9673033"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_70017"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_70017"/>
    <dbReference type="eggNOG" id="KOG0236">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003182_10_0_1"/>
    <dbReference type="InParanoid" id="C7Z8H3"/>
    <dbReference type="OMA" id="TGPMSVT"/>
    <dbReference type="OrthoDB" id="427213at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000036">
        <property type="entry name" value="Putative sulfate transporter YPR003C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="581"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="637"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU38938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="783" mass="85227" checksum="3B7BB73D1FB9BEA6" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8K0</accession>
    <name>C7Z8K0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_70087</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPAT/DAPAT family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045092.1">
        <property type="nucleotide sequence ID" value="XM_003045046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8K0"/>
    <dbReference type="STRING" id="660122.C7Z8K0"/>
    <dbReference type="GeneID" id="9673515"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_70087"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_70087"/>
    <dbReference type="eggNOG" id="KOG3729">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015023_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z8K0"/>
    <dbReference type="OMA" id="ENMICKM"/>
    <dbReference type="OrthoDB" id="10255570at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07993">
        <property type="entry name" value="LPLAT_DHAPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022284">
        <property type="entry name" value="GPAT/DHAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045520">
        <property type="entry name" value="GPAT/DHAPAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041728">
        <property type="entry name" value="GPAT/DHAPAT_LPLAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563:SF17">
        <property type="entry name" value="DIHYDROXYACETONE PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19277">
        <property type="entry name" value="GPAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="7">
        <location>
            <begin position="212"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="792"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="809"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU39379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="836" mass="94410" checksum="63522721CB8B6B15" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9T2</accession>
    <name>C7Z9T2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">40S ribosomal protein S14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_70400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044867.1">
        <property type="nucleotide sequence ID" value="XM_003044821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9T2"/>
    <dbReference type="FunCoup" id="C7Z9T2">
        <property type="interactions" value="1062"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z9T2"/>
    <dbReference type="GeneID" id="9672225"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_70400"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_70400"/>
    <dbReference type="eggNOG" id="KOG0407">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072439_6_0_1"/>
    <dbReference type="InParanoid" id="C7Z9T2"/>
    <dbReference type="OMA" id="KWGVAHI"/>
    <dbReference type="OrthoDB" id="1677536at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000002">
        <property type="entry name" value="40S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_uS11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007176">
        <property type="entry name" value="PRK09607.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU39154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="15953" checksum="2EA23D44261A76ED" modified="2009-10-13" version="1">MPPKKVARAPQENISLGPSVRDGELVFGVARIFASFNDTFVHVTDLSGRETICRVTGGMKVKADRDESSPYAAMLAAQDVAARCKELGINALHIKIRATGGNGTKTPGPGAQSALRALARAGMKIGRIEDVTPTPSDSTRRKGGRRGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAV5</accession>
    <name>C7ZAV5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_95129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044375.1">
        <property type="nucleotide sequence ID" value="XM_003044329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAV5"/>
    <dbReference type="STRING" id="660122.C7ZAV5"/>
    <dbReference type="MEROPS" id="S12.A11"/>
    <dbReference type="GeneID" id="9670693"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95129"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95129"/>
    <dbReference type="eggNOG" id="ENOG502RZX2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035614_3_0_1"/>
    <dbReference type="InParanoid" id="C7ZAV5"/>
    <dbReference type="OMA" id="FRWTNYG"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052907">
        <property type="entry name" value="Beta-lactamase/esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319:SF3">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="16"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="383" mass="41516" checksum="DE14A1B4F1E0D7A6" modified="2009-10-13" version="1">MPSNISATSPHLEAALQAVLDRGETGVSVAAYYRGKLIAHGTAGYADVSKKRPVDEKTLFPVFSVTKGITALAAHIQADRGLLNLQDPISKYWPEFAVNGKENITVEDALSHRAGIPQMPDGITPELMADWDWMIEQVAAFTPKFTPGTANAYHVLIWGWIVGEVVRRTDPKNRPFGQFVAEEICEPLSVRDLYLGVPDSELSRVATLSGGNEMFLEDTYNTSPIAVFPGSDVHNLKVVRQACDPGAGAIGNAPAIARVFAMVAEGGELDGVRLLSENYVRGMTRFRQNPYDQDKVLPIPVWFGAAGFWLGGEKGASDPLVGDHRDVIYSPGAGGSIAWADIRDRIAVSICHNNMDAGVSIDPEPIWTPIGKAIRAIIKEKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZB31</accession>
    <name>C7ZB31_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_83146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044435.1">
        <property type="nucleotide sequence ID" value="XM_003044389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZB31"/>
    <dbReference type="GeneID" id="9670746"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83146"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83146"/>
    <dbReference type="HOGENOM" id="CLU_1034751_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZB31"/>
    <dbReference type="OMA" id="HEMCTIS"/>
    <dbReference type="OrthoDB" id="5095490at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002989090" evidence="2">
        <location>
            <begin position="18"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU38722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="269" mass="27267" checksum="CA4B1F9C80B2D2B4" modified="2009-10-13" version="1">MHCRVLVSLAFALGAVASPCVPPNSVTTETSTSLETSETSTLSTTSSVPTTSSTSSDSTASSTTFDSATESTTTLATSTIISITSSATSDVTTSSTIAPTSTSSPVLETFNAIGQGGGTTGTPARLPPPQYGSITLGGYNPSNVPAGIFSIEAVTGALIVDGSKICGFYSGSQSASLYVCNATPRTNEAPVTCNQGQMDGGVLKCSAPAMACIEDFDDENDPVCYPTGGVWTQFAGFQFLGNYFFLSLASETTASTGGNIPIDLLIQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBW1</accession>
    <name>C7ZBW1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_55227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698916">
        <property type="protein sequence ID" value="EEU38436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044149.1">
        <property type="nucleotide sequence ID" value="XM_003044103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBW1"/>
    <dbReference type="GeneID" id="9670535"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55227"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55227"/>
    <dbReference type="eggNOG" id="ENOG502QUY7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038374_6_0_1"/>
    <dbReference type="InParanoid" id="C7ZBW1"/>
    <dbReference type="OMA" id="NDIVWED"/>
    <dbReference type="OrthoDB" id="5392716at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058913">
        <property type="entry name" value="Integrase_dom_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791:SF5">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24764">
        <property type="entry name" value="rva_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase core" evidence="1">
        <location>
            <begin position="162"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="493" mass="57740" checksum="D6E4A80E1FF76354" modified="2009-10-13" version="1">MARPPNPIDQYRDYVTFLYLNGVSRSKIKYKLRKRYHVAVDLSTISRRIAKWDLPRQQARTRETPELIEATRDLIFRVGLSEKQTLSVLQRQGWPVTKEGLKRIRLHPDRRWVRRLNSDEERLALLEKTEQAIIEMTRRSNAISGYGKSLLQPYLRQQKQLWWCIDGHDKLKAYGFEIYAAIDAYSRNIIWFYVGHSATTALSVLKQYLAACDAYGFRPWYLQADRGSETPLIAAAHWNFVLTTDGQVEWHGQVFQQGKRLKDSYKAAPSTKNVKIESWWERMLHVSSRQWVDYFGELARDGDFDGDMLEDQIAIYAVFEDVLRQELFDFVEAWNLHRIRLQKNRPHVVHGQPWMNYHYPDPDKACNWGIPIDRSVLHEMERPLADIDISTCLEPETKDWCLQVLRGMGYDQVVLGTSQEPDKLRPFKRFYLGLRDRIIQHIESGRQPILAYRKAPTGGVAEYVSTLSFCDVTNLNAYSKHYLNGQIKPKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZC47</accession>
    <name>C7ZC47_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_58644</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698918">
        <property type="protein sequence ID" value="EEU38199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043912.1">
        <property type="nucleotide sequence ID" value="XM_003043866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZC47"/>
    <dbReference type="GeneID" id="9670344"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_58644"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_58644"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_7_1_1"/>
    <dbReference type="InParanoid" id="C7ZC47"/>
    <dbReference type="OMA" id="NHFESCA"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF152">
        <property type="entry name" value="OXIDASE (CODA), PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU38199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="543" mass="59878" checksum="D839CE3DF4265E1E" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCG2</accession>
    <name>C7ZCG2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_77041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698918">
        <property type="protein sequence ID" value="EEU38363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044076.1">
        <property type="nucleotide sequence ID" value="XM_003044030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCG2"/>
    <dbReference type="GeneID" id="9670296"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77041"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77041"/>
    <dbReference type="eggNOG" id="ENOG502RMVY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053730_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZCG2"/>
    <dbReference type="OMA" id="YHERAVW"/>
    <dbReference type="OrthoDB" id="5290015at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU38363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="345" mass="38035" checksum="21ACADE415091CBC" modified="2009-10-13" version="1">MSNPMPRDFTVNGIKRFGITLAGPPSEPLQENTEEYTALAFAIHVGISILEKAAGRQTMTSLGTALVQAWLLGGNGFRFHGDQDQMAEYVNEFLHAIRGNFPRVILDSLGPDVIAEARRIQCQDHSFSQYNPKRAGGIYYSRSRVSQMASAAREANDTSPHGRKMAARFKTFLFMFAIATAHEITHLFVGYLAQGQDTTQSYTPPTLSYLNYAGPSWGESGRWLESHLFGGSIEFYRNISDDDGQAGIPYVLDSNAHARKIRAACVRELVTSIGEFQTFPFTTTGRALTAEERRERGLLSMGTTYVNESQSSESVLKAISTQCKPRKIQCELVLIDVIAISGSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCT2</accession>
    <name>C7ZCT2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_84330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698919">
        <property type="protein sequence ID" value="EEU37975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043688.1">
        <property type="nucleotide sequence ID" value="XM_003043642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCT2"/>
    <dbReference type="GeneID" id="9670173"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84330"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84330"/>
    <dbReference type="eggNOG" id="ENOG502SY0D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069414_3_1_1"/>
    <dbReference type="InParanoid" id="C7ZCT2"/>
    <dbReference type="OMA" id="HATHEGS"/>
    <dbReference type="OrthoDB" id="2942798at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU37975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="26273" checksum="B43017A0867CFC53" modified="2009-10-13" version="1">MAEEYDEGNWRQISVKFRFHGNTVLAAGDWSDREHPNVLRLTIIRSSFDQAIISILLALPYTFQNFARALFPGYFLPSRIVLKKMKPEWDEEFDNEVRMYDRLRSVQGHLIPICYGLAWCDGKRALLLSEVNGVLPFEQPLDSPLDADEFCRRLRAAYGELGSFGLMYGDPKLDNYLLVDDRIVIVDLESAEEAEEEGAIERVVESNVEFARDRYRSYLKNRYELM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZD13</accession>
    <name>C7ZD13_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class-III</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_84411</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698919">
        <property type="protein sequence ID" value="EEU38015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043728.1">
        <property type="nucleotide sequence ID" value="XM_003043682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZD13"/>
    <dbReference type="STRING" id="660122.C7ZD13"/>
    <dbReference type="GeneID" id="9670015"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84411"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84411"/>
    <dbReference type="eggNOG" id="KOG1404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_0_1"/>
    <dbReference type="InParanoid" id="C7ZD13"/>
    <dbReference type="OMA" id="ERDNICQ"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688:SF13">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU38015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="47556" checksum="F93FF72AEF2585E0" modified="2009-10-13" version="1">MSSNGVSTFWSRADKYLMSTGVPYSPVVITKAQGTRLYDANNRKILDFTSGQMSSLLGHSHPEIVEVVKNYVAELDHLLSNMITHPVVDLAERLARLLPAPFEKSFFLNTGSESTEAAIKMAKLYTGKFEIVAFSASYHGLTQGSGSATFSAGRKNGGPTMPGQLAFPAPYAYRSPFRKSDGSYDWETELEFGWSMIDRQSVGSLAAFIMEPILSTGGILDMPEGYLKRMSEECKKRGMLLIMDEAQTGVGRTGQMFAFEKDGVVPGILALSKTLGCGLPLASVSTTAEIAEGCQRAGFLWLTTHLNDPLTAAVGDKVLEIVERDGICQRASERGAQLREGLLKLQKKYWCIGDVRGRGLLQGVEIISDPKTKAPGSDLGQKVSDKAMELGLSCNIVNLPGMGGVFRLAPPVTVTAEEISEGLQILDEAFAYGMSTLPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDD3</accession>
    <name>C7ZDD3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_47947</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698919">
        <property type="protein sequence ID" value="EEU38078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043791.1">
        <property type="nucleotide sequence ID" value="XM_003043745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZDD3"/>
    <dbReference type="GeneID" id="9670078"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_47947"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_47947"/>
    <dbReference type="eggNOG" id="ENOG502SH77">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_12_0_1"/>
    <dbReference type="InParanoid" id="C7ZDD3"/>
    <dbReference type="OMA" id="WVFIEAN"/>
    <dbReference type="OrthoDB" id="5401779at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF124">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="67"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU38078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="415" mass="46184" checksum="649AC261E222BB29" modified="2009-10-13" version="1">MPEFPVVHGVTVAVAPPDDYDVDFEHPKRRHEIESYVVSGLGMAIAALFFLQFMYVKLGLLRKADGETACLILAWLSSIAVQAVALLHAWELSLDDYIFGSKFMVISPILYAICTGASKMSLILFYRKLSPQRWWKWSLYFVLFLVAGYNISIFFAIIFGCRPFNKHWDVRVTEGSCVNRPAIYICTAALGIASDLLLLVMPMPMIMRLQMPPRQKAGLVLLFGIGSATLVTSIVRLILLMPILTTTDTTWVISSAVVWIYVEANLLVICASLTTLRRFFIHVAPKLIGERGSSAGYAASGSKGTRGHPFRTIGSVANRGKVDKYGMDIEEAGFDLKTIGQAEPTETEVKAYETGAQPQKMIKHLRRQESINKFGDAASETRLWDPRKDSDEGDRAIVQTTTVTVVYEDRGQRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDN1</accession>
    <name>C7ZDN1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_88109</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043568.1">
        <property type="nucleotide sequence ID" value="XM_003043522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZDN1"/>
    <dbReference type="STRING" id="660122.C7ZDN1"/>
    <dbReference type="GeneID" id="9669761"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88109"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88109"/>
    <dbReference type="eggNOG" id="KOG3923">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034311_3_0_1"/>
    <dbReference type="InParanoid" id="C7ZDN1"/>
    <dbReference type="OMA" id="NIFLPWM"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF11">
        <property type="entry name" value="D-ASPARTATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="4"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU37855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="336" mass="37906" checksum="0BE432E228054FB8" modified="2009-10-13" version="1">MAKITIVGSGIIGLTIASQLSRHHEITVIARDLPGDEPSIKWASPWAGANFVAGGCSSARERRMQMDAFAELWRLAIRHPESSVKTLPMEEFYDNERSDDDLWFKDFVPGFRFLPNYQLPEGVKGGITYMTIVLNPHIFMPWLKRNLESSGVKFKRMNLDSLSDAHHFGHDVLINATGEGPKHLSDIKDQNMELLRGQTMIIKSDYKKSFMRDDGKTYTYVIPRLDGTAILGGMRDPDVENTEVDIEVDKDIVTRINRSLPEHFSADLADYEIEGHNVGIRPYRSGMRIEKETKNGQNIVHAYGITGGGFIYSFGVAREVVKLVDEFLFPDGKARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDN7</accession>
    <name>C7ZDN7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_88115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043571.1">
        <property type="nucleotide sequence ID" value="XM_003043525.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9669764"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88115"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88115"/>
    <dbReference type="eggNOG" id="ENOG502QQIR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000570_2_1_1"/>
    <dbReference type="InParanoid" id="C7ZDN7"/>
    <dbReference type="OMA" id="GETICIF"/>
    <dbReference type="OrthoDB" id="5081091at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047352">
        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="1703"/>
            <end position="1857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="797"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="864"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1315"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="797"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1355"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1413"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1432"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1461"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1483"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1520"/>
            <end position="1543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU37858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="2274" mass="255182" checksum="C239A5CAE56B4146" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZE47</accession>
    <name>C7ZE47_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="13">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">NECHADRAFT_87386</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="13"/>
    <dbReference type="EMBL" id="GG698921">
        <property type="protein sequence ID" value="EEU37541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043254.1">
        <property type="nucleotide sequence ID" value="XM_003043208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZE47"/>
    <dbReference type="STRING" id="660122.C7ZE47"/>
    <dbReference type="GeneID" id="9669168"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87386"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87386"/>
    <dbReference type="eggNOG" id="KOG0206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000846_5_2_1"/>
    <dbReference type="InParanoid" id="C7ZE47"/>
    <dbReference type="OMA" id="DAQITEY"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
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    <sequence length="1255" mass="139681" checksum="B8DEBA078987572B" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZE66</accession>
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            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">NECHADRAFT_87460</name>
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    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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            <taxon>Fusarium vanettenii</taxon>
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        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
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        <property type="entry name" value="NTF2-like_dom_sf"/>
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        <property type="entry name" value="BLR2505 PROTEIN"/>
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        <property type="entry name" value="BLR2505 PROTEIN"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="119" mass="13258" checksum="02D35FC40491CAE9" modified="2009-10-13" version="1">MVSADHIRAIFEPIARGDMASFWPHVEPDVDWTVKEFQQGTRPLSSTWAGPLHLVVQNIIVDGNQAAVELKAVDTTTKSGDPFPNEYTWVLGFNDNGKIATVRAYMDTDLVTRVIEKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEW3</accession>
    <name>C7ZEW3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_86319</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043088.1">
        <property type="nucleotide sequence ID" value="XM_003043042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEW3"/>
    <dbReference type="GeneID" id="9665285"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86319"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86319"/>
    <dbReference type="eggNOG" id="ENOG502RX9H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027816_3_1_1"/>
    <dbReference type="InParanoid" id="C7ZEW3"/>
    <dbReference type="OMA" id="FGEMTEN"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF683">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="55"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU37375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="450" mass="48019" checksum="FEA479301C5ACE2D" modified="2009-10-13" version="1">MSNPAEITPKNKIGENDLEVLGKVDSLTKISSTNTVAHDAVFGPITEDGPNYRNVGWIGTSVLMMKTQIGLGVLSIPAAFNVLGLIPGVLCLLAIAIITTWSNYMVGAFKLKHPEVYGIDDASRIMFGVVGREILSAGFSLYLIFAAGSGMLGISIGFNSISTHGTCTAAFVAVAAVGVMALASIRTLDRLSWIAWVGLVSILVAIFIVTIGVGVQDRPDDAPPGPWSSDYKLVGHPSFTAAASAIPMFVLSYAGTPFFFPIVSEMRNPRHYTKALILCQVVVTITLIKKIAYGIALPGLFASSTLAIHLVSKHFFIRFLRGSQHLVANTMTHWGTWLSCIFTCATIAYCIASGIPVFGPLIGFIGALLGTLQCFQPMGCMWLYDNWAAGKESGRSTRWALMVCWSLFVIISGTFLMIAGTYGSVLEIIAALKAKGASGPWSCLDNSNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZF01</accession>
    <name>C7ZF01_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_51338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043200.1">
        <property type="nucleotide sequence ID" value="XM_003043154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZF01"/>
    <dbReference type="STRING" id="660122.C7ZF01"/>
    <dbReference type="GeneID" id="9665305"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51338"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51338"/>
    <dbReference type="eggNOG" id="ENOG502T2R8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045857_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZF01"/>
    <dbReference type="OMA" id="YMFIAQG"/>
    <dbReference type="OrthoDB" id="5376287at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988067" description="Transcription factor domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU37487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="37906" checksum="9B572790D5B41C02" modified="2009-10-13" version="1">MISNPFIVSWWPLALADPALFHVSIQTASLDEELRAHKGFPISELLMVDSVSLIRQKIENSSLAFQDDTLNSVVTLAAIEHGKGNVEASKTHIDGVKRIVGVRGGISHVRRSSPLTARMIAWVSMLVTGTPQFPIQDDLGIGDGVCPTLQWLLASPDFESPSEAINDLDIDPTVIDILTRLRNISQEASSLSGTELHDLTCFVVHKLLLLPPLSTQNLHQSAASESLRYALALYMLAIHGTTYYSHIGLVMTIMQQFRSYLEVLVGSDVDESLKLWIFSVGMVSSIDPINSKWFTEQAYLAATSLKIQTWEDVLVHFKRILWMETPRGVIFQQHWKDMLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFH4</accession>
    <name>C7ZFH4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ethanolamine kinase</fullName>
            <ecNumber evidence="3">2.7.1.82</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_37289</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.82" evidence="3"/>
    <dbReference type="EMBL" id="GG698923">
        <property type="protein sequence ID" value="EEU37151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042864.1">
        <property type="nucleotide sequence ID" value="XM_003042818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFH4"/>
    <dbReference type="STRING" id="660122.C7ZFH4"/>
    <dbReference type="GeneID" id="9665004"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_37289"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_37289"/>
    <dbReference type="eggNOG" id="KOG4720">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012712_1_1_1"/>
    <dbReference type="InParanoid" id="C7ZFH4"/>
    <dbReference type="OMA" id="PMIWTKT"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF66">
        <property type="entry name" value="ETHANOLAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU37151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="357" mass="40271" checksum="E99FAF7F0D53BBF4" modified="2009-10-13" version="1">MQVPFVNQVFDKDDAKGSSLRLSEFLFPDALQVEERLEVKPLTQGTTNGLYKVTYRPVDAGDASAHDAVLVKVYGDGTDITIDRNKELKVHQLLAENKLSSSPLVRFANGHAYQFIHGRTCSVSDMANPVIYRGVARELARWHATLPIVEPKDPQKGLEHEPSVWATAKKWLDAIPSQPKRSKADKALLREQFHYVTGKLLLNDDKPEPLVLGHGDLLCGNIIVQDLTEPTEAASVRFIDYEHATYCPRAFELANHFAEWTGFECDYSLLPTRLTRRDFIHEYLAEIARLQQDGDHADIPGLCALIQAETSTGAIDFDYAGYAEKRLAEYWDWRRVHDGNVDADEGISQREERWAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZG67</accession>
    <name>C7ZG67_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_52316</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698924">
        <property type="protein sequence ID" value="EEU37111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042824.1">
        <property type="nucleotide sequence ID" value="XM_003042778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZG67"/>
    <dbReference type="GeneID" id="9664940"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_52316"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_52316"/>
    <dbReference type="eggNOG" id="ENOG502RVYN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_0_3_1"/>
    <dbReference type="InParanoid" id="C7ZG67"/>
    <dbReference type="OMA" id="DMAANMM"/>
    <dbReference type="OrthoDB" id="5421689at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="10"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU37111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="325" mass="36644" checksum="5649E3F1E28156B1" modified="2009-10-13" version="1">MDCSDLALLLRLKARRMTRMKLWLDDYLACVAWVGSPFENMLLVADVCTHLFRATIPSPSFTRADSIREKSRFLLWVTELLYAGSIAASKLAILSFYWRVFRYTSIRIPILVLIAAVSIWFTIRTFMVIFHCVPVQAYWDKTITRGRCLVNASTFFFCTILMRCLMDCIIFVLSVIEVAKMHLPWSKKLAVVGLFTVCIASVFILIQAIHYGPDTREFPKEIALSMIWGGVEINVAVFSACLPMLRPIFQMFIPGISTAETSRPISLPSVVLSPTPSRVNEAKQEKSRRSVAHGFVDHELPTVLRVPSNASGPESPHHARNSVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZG97</accession>
    <name>C7ZG97_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_80970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698925">
        <property type="protein sequence ID" value="EEU36877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042590.1">
        <property type="nucleotide sequence ID" value="XM_003042544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZG97"/>
    <dbReference type="GeneID" id="9669829"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_80970"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_80970"/>
    <dbReference type="eggNOG" id="ENOG502SIT3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004083_7_2_1"/>
    <dbReference type="InParanoid" id="C7ZG97"/>
    <dbReference type="OMA" id="LWQWYLD"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF77">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="140"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="193"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="648"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="668"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="683"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="697"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="719"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU36877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="792" mass="88833" checksum="DAAB9D8B040513FA" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZGZ0</accession>
    <name>C7ZGZ0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_86490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698927">
        <property type="protein sequence ID" value="EEU36605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042318.1">
        <property type="nucleotide sequence ID" value="XM_003042272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZGZ0"/>
    <dbReference type="GeneID" id="9669484"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86490"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86490"/>
    <dbReference type="eggNOG" id="ENOG502RJ42">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050401_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZGZ0"/>
    <dbReference type="OMA" id="REASHNN"/>
    <dbReference type="OrthoDB" id="2588098at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU36605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="404" mass="46551" checksum="387D5994337FDC94" modified="2009-10-13" version="1">MAQAENTLGGRFILAPLLKQKFRYPVHERCWLNVLDFALITNNSNSSNNFGALDRLHTLVHRPADLSWITRRCPSTRPSSLEKLPAEILREIVSGLGITDQMAVALCSQRLWIHTVSAIREHLSSRHKQISWAGTPIISLAAWLTSFPQALFEVVPELQCSRERLNPPGEDSPWYRDWVIGEIASSERASSPEYHVVMMEFWRQISTSDIPEDLHSRMASCLDLHALKDGAGCYLRNHTAKEYIRLELIKKKSGTIATLVGHGWLNLAILLFWLIHYNGRQPNPVPDWSDEPETGDSPWDFTLDEAGNLEFKTDLRKEEVRHFLRVGKWAAHCLDVTDEAPEEMIANWQDRTPDVEKRARNWLMAIYATSFHIRRDSQIGWWWDYWGIIVQEELKRGEVRPGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZH44</accession>
    <name>C7ZH44_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_51733</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698927">
        <property type="protein sequence ID" value="EEU36665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042378.1">
        <property type="nucleotide sequence ID" value="XM_003042332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZH44"/>
    <dbReference type="GeneID" id="9669543"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51733"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51733"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="InParanoid" id="C7ZH44"/>
    <dbReference type="OMA" id="IENFTKW"/>
    <dbReference type="OrthoDB" id="5307821at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF14">
        <property type="entry name" value="DEHYDROGENASE ARBD, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU36665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="315" mass="33928" checksum="9871091A17DA8913" modified="2009-10-13" version="1">MVPPPLPIPERTLSFSRTDPDVQVDYPQHHELPSSKPVIGQGGQFSKPTLASLSLEGKVIVITGGARGLGLVMGQGCVYSGADLAIVDLNKDEAESQVDELIDAFRKENPGCERLPRVTAHYADVSKPESVDKCIREILNTYQKIDGLVTSAGFTENFDAINYPIDRMRKLWGVNVDGTYLFAVAVAKHLMERKAPGSIVFIGSMSGAIVNVPQPQAPYNAAKAAVRHLAASLAVEWAHAGIRVNCISPGYMLTALTKKILADNPDLKKTWVSLIPQGRMGQPEDLMGPVTFLLSDAASYVTGADLRVDGGYTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHM6</accession>
    <name>C7ZHM6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-gulonate 3-dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">L-gulonate 3-dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_69838</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.45" evidence="8"/>
    <dbReference type="EMBL" id="GG698928">
        <property type="protein sequence ID" value="EEU36441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042154.1">
        <property type="nucleotide sequence ID" value="XM_003042108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHM6"/>
    <dbReference type="STRING" id="660122.C7ZHM6"/>
    <dbReference type="GeneID" id="9669184"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_69838"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_69838"/>
    <dbReference type="eggNOG" id="KOG2305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_0_1_1"/>
    <dbReference type="InParanoid" id="C7ZHM6"/>
    <dbReference type="OMA" id="ALRWSFM"/>
    <dbReference type="OrthoDB" id="2021159at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050104">
        <property type="term" value="F:L-gulonate 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF1">
        <property type="entry name" value="LAMBDA-CRYSTALLIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="13">
        <location>
            <begin position="8"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="12">
        <location>
            <begin position="195"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="10">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU36441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="319" mass="35201" checksum="918BEE981BF26E35" modified="2009-10-13" version="1">MAESEQQTIALIGLGTIGLSFAALHLRYSNANLRLYDVRDDLEHHISTLLPVYLESVKKEATETLSVQQLISIGRLSICSSIEEACSNATIVQEQGPDKIEFKQSNWASVIKYAPANAHLWSSTSGICASKQVEHLEDKTRVLVVHPFNPPHIMPLIEVVPSPHTTPERTQFAMDYFNTLGSGHRPVKINKETQGFVGNRLAFALFREACHLVANDVVSVEDLDTIMENSLAPRWAVAGPFKTYNSAGGAGGIGAFMHHLAGTMEACWDDVGDITFKGTDWTERVSRQTEEAYGRPTADSLAERDRSLQKIIQAQPSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZIZ1</accession>
    <name>C7ZIZ1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_49797</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698932">
        <property type="protein sequence ID" value="EEU35983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041696.1">
        <property type="nucleotide sequence ID" value="XM_003041650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZIZ1"/>
    <dbReference type="FunCoup" id="C7ZIZ1">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="GeneID" id="9674037"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_49797"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_49797"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012970_2_1_1"/>
    <dbReference type="InParanoid" id="C7ZIZ1"/>
    <dbReference type="OMA" id="SIGMWAF"/>
    <dbReference type="OrthoDB" id="4088837at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore-iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000197">
        <property type="entry name" value="Siderophore iron transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF92">
        <property type="entry name" value="GLUTATHIONE EXCHANGER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="442"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="517"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU35983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="553" mass="60746" checksum="201D15B36F816884" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJ63</accession>
    <name>C7ZJ63_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_96546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698932">
        <property type="protein sequence ID" value="EEU36020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041733.1">
        <property type="nucleotide sequence ID" value="XM_003041687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJ63"/>
    <dbReference type="GeneID" id="9674074"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_96546"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_96546"/>
    <dbReference type="eggNOG" id="ENOG502S51T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024934_0_4_1"/>
    <dbReference type="InParanoid" id="C7ZJ63"/>
    <dbReference type="OMA" id="NCHALYG"/>
    <dbReference type="OrthoDB" id="3546279at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU36020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="414" mass="46359" checksum="B635388231767BCF" modified="2009-10-13" version="1">MQQARSTRAGYKKSRNGCTRCKKRRVKCDEEVPCSACVRHKVPCSLASPDGEHEGIHIPDRSLHPPNPSSSGFNFSSLLCGSLFESPREDADCWVANVELMFHYSTVTYKTLCFSDQVVSTFLHDMPRLALSHPYFLREILSLSAYHLAYLHPEKRQSYVLLASKHHDLAVRGIREVLAGPITSANCHALYAAAIFIVINKFAAFPSCEDYQAHGCLMPIQALVEMFSLVNGISALLMSSEGKSILNGPLKDFFSRSIVPYPPSELFHGLLTRVPELKLRAESDALDPKAKLILITTLQCFAECLEDTINRPTVSCPPEMRVQFMWPMMVTRDFLDLAGSGHPLALVTLAYYDTLLSWAESRYWFFEGWAQPLMEAIIEKVRGSEWEDLVSWPASIVLKEKEAPLDAMGIPGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZK81</accession>
    <name>C7ZK81_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_52466</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698937">
        <property type="protein sequence ID" value="EEU35592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041305.1">
        <property type="nucleotide sequence ID" value="XM_003041259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZK81"/>
    <dbReference type="GeneID" id="9676017"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_52466"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_52466"/>
    <dbReference type="eggNOG" id="ENOG502RSJA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019101_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZK81"/>
    <dbReference type="OMA" id="GNFCHPA"/>
    <dbReference type="OrthoDB" id="2988756at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF2">
        <property type="entry name" value="SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="25"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU35592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="371" mass="41048" checksum="1A5FB4E21809ED54" modified="2009-10-13" version="1">MARDITSFAAEAFTLLSVGIMVIILRTYARIRQVGIRNFEADDYLMLLAIIPYSIETALAYTVSAKYHGYTNSAMTDEERASLSPDSEEYAWRVGGSKIQVAGWAMYASVLWVIKSALCAFYFRLTSGLANYKIRIHIGFGLIITTYIVIICCILFSCHPFHRFWQINPDPGNLCQAASSKLYIFIIVVLNIVTDTYLLLIPIPMLWGARIPTVKKYGLVVLFSGGIFVMVAGLLRCILILKNPHTGPQEGSSWAVRESFVAVVTSNLPSTWGWMRQKLKPLFGSLLSSNNTSTKYKGGPEPGSIMLGDQGVSGWRSHNGRSLKSGTRSQSVHDRNIFIHAGEASSDEIIPSRHDGITKEVEFTVSASTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMQ3</accession>
    <name>C7ZMQ3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_97459</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698957">
        <property type="protein sequence ID" value="EEU34711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040424.1">
        <property type="nucleotide sequence ID" value="XM_003040378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMQ3"/>
    <dbReference type="STRING" id="660122.C7ZMQ3"/>
    <dbReference type="GeneID" id="9678864"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_97459"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_97459"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="InParanoid" id="C7ZMQ3"/>
    <dbReference type="OMA" id="NLIQMNR"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000050">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU34711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="56850" checksum="3AE086CBA18CE311" modified="2009-10-13" version="1">MILELLIPHSFGYGQGLNKIPGPWLAGFTDLWRLFIVRGRRAQEVHIELHKKYGPMVRLGPRAVSVADPEAIKIIYSPSSGYSKSGFYPVQQALAKGNRLETMFNTANDSYHARLRRSVSNAYAMSTLVAFEPFVDSTSTEFLKQLKLRFADRPGDEGICDFGAWLQYYAFDVIGELTFSKRLGFVETGRDVDNIIRDLEGFLNYVSWIGQIPFLDRLFIKNPIKIWMAKNGLLNSSAPVAEFAKKHVVERQREEESGNSKTPRRDFLNRFKEARAKDPEFITEQLVLALTVANMFAGSDTTGITMRAVFYYLLRDPSKMDKLLDELARESKAGRFSREDGLAQWEEVRDLPYLSAVINEALRCHPAVGLTMERIVPPSGVTIAGHFLPGGTIAGCSAWVIHQNAEVFGSDAADFRPERWIDATPEQRRRMNNCLFSFGAGARTCIGKNISLLELYKLVPTILRRFELELVNPETPWKLHNAWFVRQAGFNVRLKERDQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNI5</accession>
    <name>C7ZNI5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRISE-like Rossmann-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_97472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698968">
        <property type="protein sequence ID" value="EEU34430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040143.1">
        <property type="nucleotide sequence ID" value="XM_003040097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNI5"/>
    <dbReference type="GeneID" id="9677966"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_97472"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_97472"/>
    <dbReference type="eggNOG" id="ENOG502QSRH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030125_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZNI5"/>
    <dbReference type="OMA" id="TWIETYR"/>
    <dbReference type="OrthoDB" id="1731983at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd08948">
        <property type="entry name" value="5beta-POR_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055222">
        <property type="entry name" value="PRISE-like_Rossmann-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487:SF0">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22917">
        <property type="entry name" value="PRISE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRISE-like Rossmann-fold" evidence="1">
        <location>
            <begin position="9"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="432" mass="48832" checksum="A0859AE2AF5A508B" modified="2009-10-13" version="1">MAPARGKVAFVTGANGITGNAIIEHLIRQPESEWSKIIITSRRVPKQSLWQDHRVRFIALDFLNPVEELIPLMAPFCHDVTHAFFTSYVHTANFANLRDSNIPLFHNFLVAIDIVAASTLKRVCLQTGGKYYGAHLGPTEVPLHEGMGRYDDKGENFYYPQEDFLFSLAAKRSWDWNVIRPNAIIGFTPAGNGMSLALTLAIYMLCCREMGVPPVFPGNKFFYTRCVEDCSYAPSIADLSVWATTDEHTKNEDFVHQNGDVFVWKQLWTKLGRHFNIEVPEFTEWAAEGDQERMANNFLMTEWCKDKEAVWERVVAKHGGQLEAFGWGTWDFFDWAIGKAWCTISTVSKARKFGWKRYDDTYDTFIETFHVLENAGILPQFGQTVLAPHPADAVTLRKAKAKALQNGVIENGIDHKGLESGDVENGDLTVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZP23</accession>
    <name>C7ZP23_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_101789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039951.1">
        <property type="nucleotide sequence ID" value="XM_003039905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZP23"/>
    <dbReference type="STRING" id="660122.C7ZP23"/>
    <dbReference type="GeneID" id="9677886"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101789"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101789"/>
    <dbReference type="eggNOG" id="ENOG502RNBW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019524_2_1_1"/>
    <dbReference type="InParanoid" id="C7ZP23"/>
    <dbReference type="OMA" id="FWEACET"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU34238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="457" mass="51739" checksum="C3833C2A9A61170C" modified="2009-10-13" version="1">MPGTPSSTGCEACRKQKKRCDKVQPKCGRCKRLSINCVGNGVKRWKFQSFGVEDQRLTPTPRKSPSNGKTRVASSLVHILGIEDIRYDLRAFGGKLIPDLPQQLGSSPALDACVSAMVALYRSRQYQQSKVDALSKYGEALAATRKSIQDPLEPVVTKMRTVSVMYICHSWLDRKHAEQHREMISHLFREAVEAGKAEDIEPEYFQGLTQLAVLANILNPGFELGPWFWNACKNTGPRPFRYHQGTFLSLEPTTMAEAAIYIRSPRRYQYQLRCMYNLVQSEKARIRQLVTFATMATMTPKAPPMAMRVLSSYRFAWGLLLGLGSILNHVLRIFDQDLDLVMESHQYVDEAIVLTEQTAPSRPNGAAFTPDYLKMVWASITDSYRSAEIEAILLDYENDVEGAEYLEEALAMKRRLYRMARREAQFQTQTPPEVPMLGCMQDPLDDVRVHDIGAPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPU9</accession>
    <name>C7ZPU9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_54482</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698973">
        <property type="protein sequence ID" value="EEU33971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039684.1">
        <property type="nucleotide sequence ID" value="XM_003039638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZPU9"/>
    <dbReference type="GeneID" id="9677499"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_54482"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_54482"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_2_3_1"/>
    <dbReference type="InParanoid" id="C7ZPU9"/>
    <dbReference type="OMA" id="VCMIISF"/>
    <dbReference type="OrthoDB" id="2417308at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Amino acid/polyamine transporter I"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF14">
        <property type="entry name" value="GABA PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
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        <location>
            <begin position="427"/>
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        </location>
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        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
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            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU33971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="48616" checksum="B73BBB3831242473" modified="2009-10-13" version="1" fragment="single">GGAYHYACFLVPDKYRRQIAYPLGWLNWLGWIFTHAGCCAIVANLTLGLVNLCRPDFDVSTRWQLLLVYLAIVATCWLINLWGLKGIPTLEILGCYVTAFGFIAYTIALLVKAPKASPSFVFVETHNSTGYSSTSLAILLGLFSSFSTLMGLDGPAHLAEEIPQPKRHLPRVMLIVIISQAVIGVVWILVLGFSITDMDLVVQTKTGIPVLELIRLATGSDGAAMVFCITLLINNGTSALGSAVTMSRQGYAFARDGGLIWNTKLAELSPGSHLPLWSINLPSLIVALVGVIYLFSNAAFNALVGAQATCMIISFGFPALILLVTDGKLLPANSHWNYGVFTKPIYVISVGYSILVVIVSALPQSHPVTSLNMNYTVLVMGGFSIVMGLAWVTEGRKLFKPPFSEESLVETNDVITGLTVDLEADEEASKGKNAAVSSGYDKNQSLSVTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPZ1</accession>
    <name>C7ZPZ1_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_89036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89036"/>
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    <dbReference type="InParanoid" id="C7ZPZ1"/>
    <dbReference type="OMA" id="FPIDQKE"/>
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    <dbReference type="Proteomes" id="UP000005206">
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    </dbReference>
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            <end position="196"/>
        </location>
    </feature>
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        <location>
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            <end position="234"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
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        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU33910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="533" mass="60923" checksum="64CE36B7B29D50F9" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPZ2</accession>
    <name>C7ZPZ2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_89037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698976">
        <property type="protein sequence ID" value="EEU33904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039617.1">
        <property type="nucleotide sequence ID" value="XM_003039571.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="nhe:NECHADRAFT_89037"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89037"/>
    <dbReference type="HOGENOM" id="CLU_1111653_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZPZ2"/>
    <dbReference type="OrthoDB" id="5086958at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988287" evidence="1">
        <location>
            <begin position="21"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU33904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="250" mass="28194" checksum="FF453B051FA325BE" modified="2009-10-13" version="1">MHWQLVVGFISAAVMALAAGGRYVLGNGGPHGVKLPEHLVNHAVDSNDKLERHICVAYEALFQLEPKYHISPPNFYQLLRVPPLPPAVFGDIDNDSAQTARLRTVMARLDGKMRKLFLERRALPKGPGRDNVIKAIATWNKIGSVLLHPLVRDLYEQEFGGNNVGEVLMKMCGERWEKKRRPPRPPGQILLRADDWAIFMFKMKCFLSLDVISKRLRPPTIGVYVMTYDVENLLAMSLTLCTLWPGSLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQ32</accession>
    <name>C7ZQ32_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_19779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698981">
        <property type="protein sequence ID" value="EEU33876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039589.1">
        <property type="nucleotide sequence ID" value="XM_003039543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQ32"/>
    <dbReference type="GeneID" id="9667110"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_19779"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_19779"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2746936_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZQ32"/>
    <dbReference type="OMA" id="WTDNILL"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU33876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="79" mass="8509" checksum="EB4D0E570A22158A" modified="2009-10-13" version="1" fragment="single">GDDFSNPLFTDLAPLLALFGERVTMQLMSKAMGWADNVILAVGPLGKITGIVGAIRIRCPSWFRAVIGRARESRAVPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQ42</accession>
    <name>C7ZQ42_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_82299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698982">
        <property type="protein sequence ID" value="EEU33863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039576.1">
        <property type="nucleotide sequence ID" value="XM_003039530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQ42"/>
    <dbReference type="GeneID" id="9667106"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82299"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82299"/>
    <dbReference type="HOGENOM" id="CLU_003953_4_2_1"/>
    <dbReference type="InParanoid" id="C7ZQ42"/>
    <dbReference type="OMA" id="HICEHTH"/>
    <dbReference type="OrthoDB" id="5135333at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF12">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="209"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU33863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="747" mass="85134" checksum="ECADB7731AD973AA" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQF0</accession>
    <name>C7ZQF0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_98341</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698990">
        <property type="protein sequence ID" value="EEU33757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039470.1">
        <property type="nucleotide sequence ID" value="XM_003039424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQF0"/>
    <dbReference type="STRING" id="660122.C7ZQF0"/>
    <dbReference type="GeneID" id="9666991"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_98341"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98341"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_3_1"/>
    <dbReference type="InParanoid" id="C7ZQF0"/>
    <dbReference type="OMA" id="YCANPIS"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08282">
        <property type="entry name" value="PFDH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF3">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT FORMALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="9">
        <location>
            <begin position="32"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="8">
        <location>
            <begin position="187"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU33757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="379" mass="40873" checksum="86D4BC59013BBABC" modified="2009-10-13" version="1">MALNGTMRGVVWEGVPFEMPIRSLPIPTLLAETDALVRITASAICGSDLHIYRGLYGSPEVPWTMGHEGMGYVLEVGEAVAHVEVGDYVVIPGGTDSGHLEMDGLEMGDGSGCQAEYVRVPYADMSLIPIPNEVGRAANNTNSTSTSSGARDVDYLFLSDIFPTGWAALDFARFEPGDTVAVFGAGPVGLLSAHSAIIRGASKVYVVDYVQSRLDLAESIGAVPINFVDTDPVEEILRYEPNGGVIRSVDCVGAEAFNRDLEIEQDIIIRQMIAVTRIGGGIGQVGVTSAFPDTPGTPRGSTISPNITFPLASFHDKRLSFTSGGVDHKSYAPMLSDLISTGKARPSFIIDREINIEEAPKYYQRFERREDIKIVIRFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQS8</accession>
    <name>C7ZQS8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acyl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_56371</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG699010">
        <property type="protein sequence ID" value="EEU33621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039334.1">
        <property type="nucleotide sequence ID" value="XM_003039288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQS8"/>
    <dbReference type="STRING" id="660122.C7ZQS8"/>
    <dbReference type="GeneID" id="9666856"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_56371"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_56371"/>
    <dbReference type="eggNOG" id="KOG0139">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_2_1"/>
    <dbReference type="InParanoid" id="C7ZQS8"/>
    <dbReference type="OMA" id="GFPHDFH"/>
    <dbReference type="OrthoDB" id="435240at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00567">
        <property type="entry name" value="ACAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000012">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="8">
        <location>
            <begin position="36"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="7">
        <location>
            <begin position="153"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="6">
        <location>
            <begin position="265"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU33621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="46775" checksum="B2F3CFDDB367A6DB" modified="2009-10-13" version="1">MTTCNTRLSRWSPVPGARSIHARATEFLPSSLPEWTDSQRAVREAIAKICAKYPDEYWLKRDNNHEFPWELSKDLAKDGWLGICLPERYGGSELGISEAAVMLQTISESGAGQGGASSIHMNIFGLEPIVKFGSEDQKDRWLAPLIQGKERACFGVTEPNSGLDTLRLQSFARRKGDYYELSGSKVFISTAQVSEKILILVRTTPLEDVRKNEPNQGLSLFYTNLDRSAVEVKEIQKMGRAAVDTNALFFDGWKVPAKDLVGQEGEGFRMIMHGMNAERILIGAEALGLGYAALRRACNYANERVVFGRPIGSNQGIQHPLAECWMNLESARLVVYLAARLYDQGYQDGEYANTGKYLAAEAAFKTAERAILTHGGMGYAKEYHVERYLRESMISRIAPVSGELIKNYIGQRVLGLPKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQU1</accession>
    <name>C7ZQU1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_56408</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG699012">
        <property type="protein sequence ID" value="EEU33610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039323.1">
        <property type="nucleotide sequence ID" value="XM_003039277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQU1"/>
    <dbReference type="GeneID" id="9666844"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_56408"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_56408"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="InParanoid" id="C7ZQU1"/>
    <dbReference type="OMA" id="FFTYYMM"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF6">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="37"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU33610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="552" mass="60692" checksum="4F39CA5D41F45C4C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQZ3</accession>
    <name>C7ZQZ3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_98423</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG699020">
        <property type="protein sequence ID" value="EEU33567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039280.1">
        <property type="nucleotide sequence ID" value="XM_003039234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQZ3"/>
    <dbReference type="STRING" id="660122.C7ZQZ3"/>
    <dbReference type="GeneID" id="9666811"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_98423"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98423"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_3_1"/>
    <dbReference type="InParanoid" id="C7ZQZ3"/>
    <dbReference type="OMA" id="YPIPWID"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000115">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF238">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01680)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="11"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU33567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="438" mass="49519" checksum="97FECFE77558491E" modified="2009-10-13" version="1">MDRYSGYTDFAVLVVIGAGLGGLAAALSVKQESPGHDVLVVESAPVLAEIGAGLQLTPNATRLLLRWGLKPGLEKLASSPEEFLVRRFDGRKLLGERQNFAAEMLDKYRSPYWDMHRADLQLAMFKRAKSLGVRFQFGTLVKDMDLSIPQLTTDKGDKITGDLVIAADGLWSNTRSKVLGRPSRPIATGDLAYRIVLKSEEIQDQELLDFMNKPRVCLWVGPECHAIYYPLRNNTMANIVLLVPDNLPDNVAKMPGDLSEMREIFDKWDPLLQRFLCQVNKIEKWKLMHLNELERWYNEEATVVFLGDAYHPMLPYMAQGAGSAIEDGAALGTLLSKIKSKEELPSALKTYQDLRVPRSTALQKWSIKQRHINHLPDGPEQEARDKLAESQLYDQQPGYPFYWIDPGAQDFVYGYDVIAELSSLKEPEIIYLPYYKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQZ9</accession>
    <name>C7ZQZ9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_102299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699022">
        <property type="protein sequence ID" value="EEU33554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039267.1">
        <property type="nucleotide sequence ID" value="XM_003039221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQZ9"/>
    <dbReference type="GeneID" id="9666796"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102299"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102299"/>
    <dbReference type="HOGENOM" id="CLU_880260_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZQZ9"/>
    <dbReference type="OrthoDB" id="5101650at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU33554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="316" mass="35540" checksum="5388609E4453A920" modified="2009-10-13" version="1">MHNIIQWQPGKGGTLSRPDADVRTDVLGILKKIPKNEDGWARGVPQTDEDVAALFCKLTLTGQYSPASRKAMACADLITALANTLDSSNQLDLMTLIDACEVGVKQGELSLDQARNLVRLRVDKPDTSLDGMRWGTQRFIRMLDELHSHGAVGTRVYEVAIRRPNALFRLANFTERHMQILLEERESIYRPQSQLDSTCLRVPNIVYVLFAGRFSQKRSLIASIAESRGWRIVKIDDWKPQLFRLGPLTFLPMSPGHISTVMLLQEGGAVTLVDDTDREIRWEPGELFCYVGQGVHNRSKGDRPFCLLVQLAVEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZR31</accession>
    <name>C7ZR31_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_89394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699027">
        <property type="protein sequence ID" value="EEU33527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039240.1">
        <property type="nucleotide sequence ID" value="XM_003039194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZR31"/>
    <dbReference type="GeneID" id="9666762"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89394"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89394"/>
    <dbReference type="HOGENOM" id="CLU_618334_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZR31"/>
    <dbReference type="OrthoDB" id="10345227at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="268"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU33527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="443" mass="48686" checksum="371774C013AD05B2" modified="2009-10-13" version="1">MSDTQGTPAGTPPDGLSRLPARTQKGIDGIQKLMGKTPMELIPECPNTRWSMNLVEEFRSLVNVVKKQRNPTPYSFDEIKSFLLEKVQEHDLKKRTSLEASDVRAAKYHFFGGGQGAGEDNGDEDNAVPGLRNKRLTRESSAETIPQSATHSSPSTAEHPRDSITVDPQLNISAFGTSTASGVRADRVAIDSHKLMVASQVPRCSMSPIRDDEQSPEGPINDHTASTLPFPSSDERDFRTGLSNVIQQCETSVGFLIARAGREQASGAEQQQRNLNHARDIHKRHEGEVAKHNKTSAEAKDNLVRATKMLEVAEALFAALENAVGTLDAPPETYLAQVTHSRDKAIIKHDLASQRDNIEVKKLKKAKRNRAEVAQQVVDLQAELETQEDDQAKDAQAMVGAETLRKLPKLHVTDLKPLIDGFPGFMDAVDRMAENRKGKELGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZR52</accession>
    <name>C7ZR52_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_89420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699033">
        <property type="protein sequence ID" value="EEU33504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039217.1">
        <property type="nucleotide sequence ID" value="XM_003039171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZR52"/>
    <dbReference type="GeneID" id="9666738"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89420"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89420"/>
    <dbReference type="HOGENOM" id="CLU_871819_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZR52"/>
    <dbReference type="OrthoDB" id="10654377at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU33504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="319" mass="33655" checksum="6BB6B832B2D3EC06" modified="2009-10-13" version="1">MGYLLLWSYVEKFKCVARLSAPLAYQVRYANSNAPQVFVFANGFIMAKCGANKIVEFVWGDDFLCYALSEIPYSLPPPGWSRYQAHDSSLPGELAAVVVLECAADVPGGSIDCLDHGRHAGVDADGAEVTELQCGARARDSPCGEFSVDETRVEDEAGQPRLLEVEAADEPVQCRLAVTVGALGGREVGQALHGANGSDQSRDGYEDGVSSLASAEKVRGGLEEGDRAKQIDLQVLVDAVNRALADGGSVSGDASIGNDNVQSLDPMLLLERAHRLGSVGRNAGVELDGDEPGALPLGRSSRALEFGCSGSRTARIMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7YI96</accession>
    <name>C7YI96_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1479 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_31259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054476.1">
        <property type="nucleotide sequence ID" value="XM_003054430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YI96"/>
    <dbReference type="GeneID" id="9664531"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_31259"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_31259"/>
    <dbReference type="eggNOG" id="ENOG502QR55">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011148_3_2_1"/>
    <dbReference type="InParanoid" id="C7YI96"/>
    <dbReference type="OMA" id="MFQGWVA"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU48763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="53877" checksum="346E70C71CD8508A" modified="2009-10-13" version="1">MASNGHHRHGPSSSMFAQTTEALPLPSRFARIKRGLVAGKEDQIKASWTRLLVKLKTEIDIVASKGPDIFPSIEFDHLKKDSEAAEFSSQLKERGVAVIRGVIPRDVATQWKTETDQYLKEDPRAQRLPTHDPHLYGIYWSPAQIKARGHENVLYTQRFLMNLWRSSDPAALVSPNFPVSYADRMRIRHPEDETCSLSVYVDGGSVERWESDGYGSAGTYQRIWDGEWEEWDPWESSTRLKVTSDLYNGDGSCSLFRMFQGWISLSDLPVGEGTLLLCPMIRLTTAYLLLRPFFVPNESSPTHPSFLSPDNWTLEQPPSSVIQGALPAYPQELNEAFHPHLQLNRSMIPIPKLAPGDYLVWHCDAVYALDRLSRPDLPTTAILYLPACPLTQTNALYLVRQRKALLHGESGPDFGGARAGDLPLEAEEAVQKVGEAGGADGMRAMGLLPWDEDDARDDCEFSVLEMANGILFPEKYDMDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIV7</accession>
    <name>C7YIV7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cep57 centrosome microtubule-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_30608</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053874.1">
        <property type="nucleotide sequence ID" value="XM_003053828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIV7"/>
    <dbReference type="STRING" id="660122.C7YIV7"/>
    <dbReference type="GeneID" id="9676508"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_30608"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_30608"/>
    <dbReference type="eggNOG" id="ENOG502S7ZB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005779_0_0_1"/>
    <dbReference type="InParanoid" id="C7YIV7"/>
    <dbReference type="OMA" id="MKSDQIY"/>
    <dbReference type="OrthoDB" id="76453at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051756">
        <property type="entry name" value="Centrosomal_MT-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024957">
        <property type="entry name" value="Cep57_MT-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025925">
        <property type="entry name" value="PPC89_CLD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19336:SF9">
        <property type="entry name" value="SPINDLE POLE BODY PROTEIN PPC89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19336">
        <property type="entry name" value="UNCHARACTERIZED DUF1167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14197">
        <property type="entry name" value="Cep57_CLD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06657">
        <property type="entry name" value="Cep57_MT_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPC89 centrosome localisation" evidence="7">
        <location>
            <begin position="390"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="PPC89 centrosome localisation" evidence="7">
        <location>
            <begin position="575"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="Cep57 centrosome microtubule-binding" evidence="6">
        <location>
            <begin position="943"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="94"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="664"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="817"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="336"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="488"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="230"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="709"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="752"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="818"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="831"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU48161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1065" mass="120288" checksum="52F83A81FC436066" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLL3</accession>
    <name>C7YLL3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Casein kinase II subunit beta</fullName>
            <shortName evidence="4">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_91734</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 4">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer composed of two alpha chains, one beta chain and one beta' chain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053000.1">
        <property type="nucleotide sequence ID" value="XM_003052954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YLL3"/>
    <dbReference type="FunCoup" id="C7YLL3">
        <property type="interactions" value="541"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YLL3"/>
    <dbReference type="GeneID" id="9671045"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_91734"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_91734"/>
    <dbReference type="eggNOG" id="KOG3092">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034027_1_1_1"/>
    <dbReference type="InParanoid" id="C7YLL3"/>
    <dbReference type="OMA" id="QNGSPMA"/>
    <dbReference type="OrthoDB" id="2275560at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030291">
        <property type="term" value="F:protein serine/threonine kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060962">
        <property type="term" value="P:regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006356">
        <property type="term" value="P:regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000004">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="59"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="287"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="308"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00062110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU47287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="341" mass="38324" checksum="D2AB5EA088DC8AFA" modified="2009-10-13" version="1">MSTSSGVPESWISSFCSLLGHEYFAEVSEEFIEDDFNLTGLQTQVAMYKEALEMILDVEPEDDEDEDEDEEEEDENESDPERLARQPGERRHHRMASDLSVIESSAEMLYGLIHQRFICSRAGIQQMSEKYELGHFGCCPRTNCDQARTLPVGLSDIPGEDTVKLFCPSCLDVYVPPNSRFQTVDGAFFGRTFGSLFLLTFPEYDLTKRGIEVLSTSGSRVNDGEGLINGMYAKNIGPGLGPGRIYEPRIYGFRVSERARSGPRMQWLRDRPTNINELDEARLYAEQNPDSDEEEENGSQGGVNGRVMVRRRPPGNARLRQRQNHNGSPMALSTNGAESEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLS6</accession>
    <name>C7YLS6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_91783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GAMAD family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052538.1">
        <property type="nucleotide sequence ID" value="XM_003052492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YLS6"/>
    <dbReference type="STRING" id="660122.C7YLS6"/>
    <dbReference type="GeneID" id="9663804"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_91783"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_91783"/>
    <dbReference type="eggNOG" id="ENOG502S7RW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113002_0_0_1"/>
    <dbReference type="InParanoid" id="C7YLS6"/>
    <dbReference type="OMA" id="DFAAMIW"/>
    <dbReference type="OrthoDB" id="9985637at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10779">
        <property type="entry name" value="DYNEIN LIGHT CHAIN ROADBLOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Roadblock/LAMTOR2" evidence="2">
        <location>
            <begin position="13"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU46825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="136" mass="14548" checksum="E5FBC3858B90BA61" modified="2009-10-13" version="1">MTDSALGNGPDALEEKLGRLSKKPGVKASIVLDRATGAILKTSGQVDALQTSKTRTTSTATAFSNDAPALEESETQGVEQFAAVVWNYVNSSGSLVQELDGEDEVKLLRLRTKKQELVIVPDPKYLLIVVHDTPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C7YN84</accession>
    <name>C7YN84_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_78140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053293.1">
        <property type="nucleotide sequence ID" value="XM_003053247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YN84"/>
    <dbReference type="GeneID" id="9671323"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78140"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78140"/>
    <dbReference type="HOGENOM" id="CLU_2050247_0_0_1"/>
    <dbReference type="InParanoid" id="C7YN84"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU47580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="120" mass="13507" checksum="C1920065D15901B9" modified="2009-10-13" version="1">MVQFEEKYKAGMPTSIVSELALESEEVICQRIVAKIMTALAIFVAVCLYLTAFICLLNLREDPDSEWHNVFVWAYFACAIVATLISFVVLLLKEISNKYLRPDLEAGLPSEETSLIDIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNH6</accession>
    <name>C7YNH6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_67747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052835.1">
        <property type="nucleotide sequence ID" value="XM_003052789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNH6"/>
    <dbReference type="GeneID" id="9671367"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_67747"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_67747"/>
    <dbReference type="eggNOG" id="ENOG502SARD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096567_3_0_1"/>
    <dbReference type="InParanoid" id="C7YNH6"/>
    <dbReference type="OMA" id="CIRFLQF"/>
    <dbReference type="OrthoDB" id="5363290at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42083">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42083:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU47122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="17528" checksum="1FA88C1BB1859E0A" modified="2009-10-13" version="1">MGIKDLAVSYVLFSALHLCCFALALTTCGLYGTDLHRANQQHKYSDSKWVYAVVVGSISAVTCVVYFVPFILRIAGVVVAIWDFILFILWIALFGVFGKMYISEDAEGDSDVQRMKNAVWVDLASALLWLIATLAALGYWWKHRDTRSRFTGRAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNI8</accession>
    <name>C7YNI8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF4E3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_36044</name>
        <name evidence="3" type="ORF">NECHADRAFT_84813</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">77-13-4</strain>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050072.1">
        <property type="nucleotide sequence ID" value="XM_003050026.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052843.1">
        <property type="nucleotide sequence ID" value="XM_003052797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNI8"/>
    <dbReference type="STRING" id="660122.C7YNI8"/>
    <dbReference type="GeneID" id="9664411"/>
    <dbReference type="GeneID" id="9665431"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_36044"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84813"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_36044"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84813"/>
    <dbReference type="eggNOG" id="KOG1669">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043552_0_0_1"/>
    <dbReference type="OMA" id="DNANLWT"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000015">
        <property type="entry name" value="Translation initiation factor eIF4E3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF18">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E HOMOLOGOUS PROTEIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="295"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU44359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU47130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="36860" checksum="86025153CE9DA062" modified="2009-10-13" version="1">MDNLWARRTNSGKLSLSTPGQGSSGDSFSRNASFPKRQGGDTPSSSKQNPFNTTPGGLVSPTSGASSAFGLGSGAFASFGSAKTPKSSANPFDSAMGTAVAKSGQPKDLSKVVGKAPSMASISEGSQGAAAAAPVSHQLMEPWTFWYRPPISKAHGFIEYEKTLHEIATVRTVEEFWEIFSYLKRPSSLPVVSDFHLFKKGVRPIWEDDVNKKGGKWVVRMKKGVADRYWEDLMLSLIGDQFGDAGEDVCGAVLSVRNGEDILSIWTRTDGGRVIKIRETMKHVLNFPPNTRVEFKSHDSSIQQRTAIEEQRREKAGQHHHHDKRHTGGVSKQPSEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7YP28</accession>
    <name>C7YP28_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Delta 8-(E)-sphingolipid desaturase</fullName>
            <ecNumber evidence="5">1.14.19.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">NECHADRAFT_103962</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.18" evidence="5"/>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051933.1">
        <property type="nucleotide sequence ID" value="XM_003051887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YP28"/>
    <dbReference type="STRING" id="660122.C7YP28"/>
    <dbReference type="GeneID" id="9673086"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_103962"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_103962"/>
    <dbReference type="eggNOG" id="KOG4232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016265_3_1_1"/>
    <dbReference type="InParanoid" id="C7YP28"/>
    <dbReference type="OMA" id="LYNCNYF"/>
    <dbReference type="OrthoDB" id="260091at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF30">
        <property type="entry name" value="DELTA 8-(E)-SPHINGOLIPID DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="22"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="121"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEU46220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="582" mass="66897" checksum="AEA8014D3CD786B8" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7YP99</accession>
    <name>C7YP99_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Altered inheritance of mitochondria protein 24, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_68059</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the AIM24 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051975.1">
        <property type="nucleotide sequence ID" value="XM_003051929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YP99"/>
    <dbReference type="GeneID" id="9673128"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_68059"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_68059"/>
    <dbReference type="eggNOG" id="ENOG502RXC5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046558_0_0_1"/>
    <dbReference type="InParanoid" id="C7YP99"/>
    <dbReference type="OMA" id="QTRCVQI"/>
    <dbReference type="OrthoDB" id="5295771at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="entry name" value="Mitochondrial biogenesis AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36959">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36959:SF2">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="TRAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="343"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="347"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU46262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="390" mass="42395" checksum="06E4C5B6CC380D8D" modified="2009-10-13" version="1">MRGQLPLLRTARGLRLLRLTPPPPSYVCTQCRTIQISAAPSTETPKAGADAFGALETRDPADARFEVLGAPYSLLSVTLSASQKLYTRRGTLVAVAGKPDSAQSTLSILNPATRAFLGVPFLYQRISATTPITALIATKSPTTTFTVLHLDGTTDWMVSQRNALLAWTGHTLSPSARLQTGLTLAHWGNTHLTGRGLAALSAPGQIYELTLKEGEEFVAHPGSVVAYTVGRHAPQPFRFKSNSLRIQVPSLSRWIPEAEWMKTVRNSEAYKFLARALYSLRTATRRTIWGDRLFLQFHGPSRILMSSRGVRASDVLTNRQVDEIADAPAGVLAQALELTNKPKLSDGSASKTSPVESAKQGQATGIHVAPAEKDGKVKFEDDKDLKEFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPE7</accession>
    <name>C7YPE7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucan 1, 4-alpha-glucosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_38392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051998.1">
        <property type="nucleotide sequence ID" value="XM_003051952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YPE7"/>
    <dbReference type="STRING" id="660122.C7YPE7"/>
    <dbReference type="GeneID" id="9668622"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_38392"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_38392"/>
    <dbReference type="eggNOG" id="ENOG502SN8F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030050_1_0_1"/>
    <dbReference type="InParanoid" id="C7YPE7"/>
    <dbReference type="OMA" id="ANRRVCY"/>
    <dbReference type="OrthoDB" id="5206740at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU46285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="54067" checksum="1204E9A8C70CEEFC" modified="2009-10-13" version="1">MASTQAPSKRPRLSLQIKTSCSPTTRSSRSYAVDPKDPTAFNTLSNVYVTTIERSTPVQTEPMTAINTLEAFSLTTPMDAKHRVVTPYVASYPETPSSENAPSPTRLEINYPSTMTATPPLSAGPVDSHTSRPFSFSAADTSATDGQEVTSRSETLSPLRQQSLADVALQAPYTHPRSLHSILRNSPLPPPTAIPPFSPRRQSRRLQEKANRRVGYSKPLTQEIITNKYTKSHIDLLVEEASPHSPPCLPPMPQNAVDLALAFTPNEIQDGGQTPGPFTDTKRRLGMLITGTSPSPQGTSPAGAGPKGVLKRKRKEKKRRWVWTIGQDEEDDEHVGGSIAALRAEAAKPKTAEEVKTPLTAIKIPQITYSTMPTPSIESADSESESFDHDVEMSDTSSCLSVPDEYDANMDVDLKTPTAPQKPSSNVDNKRDTPVPADLLNVEGGRDDTPIPAELLNASGKRDTPIPSDLLSLDGKRDDTPIPSELLDVDIASGLGLARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRW0</accession>
    <name>C7YRW0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pleckstrin homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_93686</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
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        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
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                <person name="Selker E.U."/>
                <person name="Salamov A."/>
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                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
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        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42336">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU45658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="250" mass="27188" checksum="9E7A808A84FA3F26" modified="2009-10-13" version="1">MLSSLTTKLALKKAGIPRDILDFQQQPEKSSSKSNQDDQPPQRGSWMSIRSLPLTVQPWLNPPPPSVAVGRVPGIGDKAPVDRERRIVLGGRRRTLLVFLRCVGCASVSHASEQATQKWVSLLGGSWGVRVVIDEDRALYAAWGLGTGGMWYLFNPTTQVQGWKETGWLGEKVAGAIQRKGLDDKKAPKKVAALDDDDEDEDGPLTVMGNKWQEAGAFAIDGTGTVIWGGKAMRADDVMELEDGARILLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSS6</accession>
    <name>C7YSS6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_13054</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051003.1">
        <property type="nucleotide sequence ID" value="XM_003050957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSS6"/>
    <dbReference type="GeneID" id="9668334"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_13054"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_13054"/>
    <dbReference type="eggNOG" id="ENOG502SIT3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004083_7_2_1"/>
    <dbReference type="InParanoid" id="C7YSS6"/>
    <dbReference type="OMA" id="YHGYEPI"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF57">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="5"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU45290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="535" mass="61350" checksum="86547E1D3558E69D" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7YTA3</accession>
    <name>C7YTA3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_40720</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051091.1">
        <property type="nucleotide sequence ID" value="XM_003051045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YTA3"/>
    <dbReference type="GeneID" id="9668489"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_40720"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_40720"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_3_1"/>
    <dbReference type="InParanoid" id="C7YTA3"/>
    <dbReference type="OMA" id="GWIHIRK"/>
    <dbReference type="OrthoDB" id="4160219at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF6">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="86"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="579"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="588"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU45378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="605" mass="63297" checksum="C8665C0556C63E54" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7YTJ6</accession>
    <name>C7YTJ6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Stress-associated endoplasmic reticulum protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_102809</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Interacts with target proteins during translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation and facilitate correct glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the RAMP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049970.1">
        <property type="nucleotide sequence ID" value="XM_003049924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YTJ6"/>
    <dbReference type="FunCoup" id="C7YTJ6">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="GeneID" id="9675130"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102809"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102809"/>
    <dbReference type="eggNOG" id="ENOG502SDGZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_182424_0_0_1"/>
    <dbReference type="InParanoid" id="C7YTJ6"/>
    <dbReference type="OMA" id="SWFTRIT"/>
    <dbReference type="OrthoDB" id="16679at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010580">
        <property type="entry name" value="ER_stress-assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06624">
        <property type="entry name" value="RAMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU44257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="67" mass="7645" checksum="984AE3861AC513DE" modified="2009-10-13" version="1">MAQTPEQRRRNAKFAKENEAKMGKSEGQIKQRVKETPKSPISLFWVVLLGFIIFGGLVFEAISRFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7YTV3</accession>
    <name>C7YTV3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CTLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_49229</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050398.1">
        <property type="nucleotide sequence ID" value="XM_003050352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YTV3"/>
    <dbReference type="STRING" id="660122.C7YTV3"/>
    <dbReference type="GeneID" id="9675183"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_49229"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_49229"/>
    <dbReference type="eggNOG" id="KOG0293">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_25_1"/>
    <dbReference type="InParanoid" id="C7YTV3"/>
    <dbReference type="OMA" id="GHISGCV"/>
    <dbReference type="OrthoDB" id="972532at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051350">
        <property type="entry name" value="WD_repeat-ST_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838">
        <property type="entry name" value="WD REPEAT PROTEIN 26-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23627">
        <property type="entry name" value="LisH_WDR26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CTLH" evidence="5">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="377"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="561"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU44685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="620" mass="68219" checksum="66F1736A482BF26A" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C7YU48</accession>
    <name>C7YU48_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_71878</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050453.1">
        <property type="nucleotide sequence ID" value="XM_003050407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YU48"/>
    <dbReference type="FunCoup" id="C7YU48">
        <property type="interactions" value="1065"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YU48"/>
    <dbReference type="MEROPS" id="T01.984"/>
    <dbReference type="GeneID" id="9665426"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_71878"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_71878"/>
    <dbReference type="eggNOG" id="KOG0177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_12_0_1"/>
    <dbReference type="InParanoid" id="C7YU48"/>
    <dbReference type="OMA" id="MKRDHDK"/>
    <dbReference type="OrthoDB" id="268428at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03758">
        <property type="entry name" value="proteasome_beta_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000008">
        <property type="entry name" value="Proteasome subunit beta type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035206">
        <property type="entry name" value="Proteasome_beta2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU44740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="203" mass="22308" checksum="0788854AB834A2FC" modified="2009-10-13" version="1">MEVLLGITGKDFTIIAASKAAMRGATILKASDDKTRALNKHTLLAFSGEAGDTVQFAEYIQRNAQLYSMRNESDLSPSGLAHFVRGELATSLRSRKPYNVNLLMGGVDPITGKPSLYWLDYLASLADVPYAAHGYAQYYCLSILDKHHHPDITLGQGIKILTMCTDELKRRLPIDFKGMVVKAVKADGIVDIEFDDDKVVKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7YUH3</accession>
    <name>C7YUH3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_63698</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050517.1">
        <property type="nucleotide sequence ID" value="XM_003050471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YUH3"/>
    <dbReference type="GeneID" id="9665565"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_63698"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_63698"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_3_1"/>
    <dbReference type="InParanoid" id="C7YUH3"/>
    <dbReference type="OMA" id="HKLHNNL"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="75"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU44804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="568" mass="60655" checksum="E7A9DAB86D48E839" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>C7YUU9</accession>
    <name>C7YUU9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_96390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050583.1">
        <property type="nucleotide sequence ID" value="XM_003050537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YUU9"/>
    <dbReference type="GeneID" id="9665706"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_96390"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_96390"/>
    <dbReference type="eggNOG" id="ENOG502RNV0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010839_0_0_1"/>
    <dbReference type="InParanoid" id="C7YUU9"/>
    <dbReference type="OMA" id="HESLLHM"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF15">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="11"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="491"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU44870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="589" mass="64950" checksum="8810F2A14ACED9B2" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7YV50</accession>
    <name>C7YV50_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_85152</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050636.1">
        <property type="nucleotide sequence ID" value="XM_003050590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YV50"/>
    <dbReference type="STRING" id="660122.C7YV50"/>
    <dbReference type="GeneID" id="9675018"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85152"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85152"/>
    <dbReference type="eggNOG" id="ENOG502SUZ5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_316885_0_0_1"/>
    <dbReference type="InParanoid" id="C7YV50"/>
    <dbReference type="OrthoDB" id="5091377at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="42"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="705"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU44923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="920" mass="103353" checksum="56F222783126644B" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVE0</accession>
    <name>C7YVE0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-mRNA-splicing factor CWC24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_85242</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the CWC24 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050282.1">
        <property type="nucleotide sequence ID" value="XM_003050236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVE0"/>
    <dbReference type="FunCoup" id="C7YVE0">
        <property type="interactions" value="306"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YVE0"/>
    <dbReference type="GeneID" id="9674707"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85242"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85242"/>
    <dbReference type="eggNOG" id="KOG1813">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050460_0_0_1"/>
    <dbReference type="InParanoid" id="C7YVE0"/>
    <dbReference type="OMA" id="ERQIDND"/>
    <dbReference type="OrthoDB" id="25761at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034247">
        <property type="term" value="P:snoRNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16539">
        <property type="entry name" value="RING-HC_RNF113A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039971">
        <property type="entry name" value="CWC24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930:SF0">
        <property type="entry name" value="RING FINGER PROTEIN 113B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930">
        <property type="entry name" value="ZINC FINGER PROTEIN 183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="4 5 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="210"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU44569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="279" mass="31083" checksum="C826C98C50569C79" modified="2009-10-13" version="1">MSALVSPGPAETTVTAPITFKQRGRRAKESFRKRPASSTIASARDNPDASSSSSDEHDTLEGPRIKRGKKGIVPTSTNVKTTLSEDHGPTAFRANRDIPLSDTNDATKRKDWYDQPTAKGPARAASNVRITTTTDFARDLCKDYAKTGWCGFGDSCVFLHDRSDTQQGWQLDREWEVHNKKKKLPSTTNKGEDNGNADDDTTLDSVPLSCPICEGPYKRPIVTQCGHYFCEACALQRYRKDPTCRSCGAATMGVFNAASRLERLMRRKREREEETTDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7YY78</accession>
    <name>C7YY78_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_101230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048855.1">
        <property type="nucleotide sequence ID" value="XM_003048809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YY78"/>
    <dbReference type="FunCoup" id="C7YY78">
        <property type="interactions" value="353"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YY78"/>
    <dbReference type="GeneID" id="9667795"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101230"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101230"/>
    <dbReference type="eggNOG" id="KOG2241">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009710_6_6_1"/>
    <dbReference type="InParanoid" id="C7YY78"/>
    <dbReference type="OMA" id="QVCRTVC"/>
    <dbReference type="OrthoDB" id="19141at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10304">
        <property type="entry name" value="GST_C_Arc1p_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02799">
        <property type="entry name" value="tRNA_bind_EMAP-II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000199">
        <property type="entry name" value="tRNA-aminoacylation cofactor ARC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053836">
        <property type="entry name" value="Arc1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF33">
        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21972">
        <property type="entry name" value="Arc1p_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="GST C-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="TRNA-binding" evidence="6">
        <location>
            <begin position="194"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU43142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="41868" checksum="43B08089AC5A7AA0" modified="2009-10-13" version="1">MASFASQTYTPTEEAEIQQWLTTSERLKSNEDKSSILETLNDHLSSRSTLLGSKPSKADVAIYETLAPVVAKWTPEERTGEKGHPNIVRHIDFVQNSTLFGLEVKDEDKVKVDQDNVLYVKPLVDAKAEKEKKKKAAAAAAAGGEASLVDRTKEKVKEVVEEAKEKVAGAKPKKEKKEKAPKQKAAPAPAAPLSPALIDLRVGHILKAINHPDADSLYVSTIAVGDQPGNDDYVEYEGQICRTVCSGLNGLIPLEEMQGRKVVVVCNLKPVKMRGIKSCAMVLAASPKVKEGEDDHKGPVELVSPPEGAKAGERVWFEGWEGKPEGVLNPKKKIWETFQPGFTTTDSLEVAFDAGVVEQLGKTGQGRLVTESGGVCTVPSLKDAVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYI4</accession>
    <name>C7YYI4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_95468</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048908.1">
        <property type="nucleotide sequence ID" value="XM_003048862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYI4"/>
    <dbReference type="GeneID" id="9665495"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95468"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95468"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="C7YYI4"/>
    <dbReference type="OMA" id="WGAMAMI"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF9">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU43195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="52057" checksum="437F4EA1D49E2B49" modified="2009-10-13" version="1">MASSKDISDPMVASHVLKEGGVKPHIDIDLRVLPLLFFMYLFNALDRNNLGAAKTDGIDVDLGFTKHEYNILVSVFYVPYCALTVPANMFTRKLSARWTLPCYLLFWGTTVILSPACKNFAGLAALRILLGMAEAGFGVGGLAKRIAPFYGSQTFSGAFSGLIAFGLFQIEGSLHDWQCLYLVEGALTITIGLIALVFLPHPPHKESSFLTDREREICRLRSLRDASQAVGSKFQIRDFFAPLRDWKLWAWAFIAFCFGVTNASVGNFTPLIVAKLGYSAVKTNLYTVPPYMVSAVLLFSTAISSDYFRERTYHLLSAFTLSCTGFIIIASIDVESHIGVAYFAVFLIVGGCFTPSIVFHSWHQNNILSEDRRAFNIAFITFFGNAAGLVSSNVFTPDSAPKYIPALVTNYSFLAAAIIVTILMRLWMQRQNALRNTAQGVNWTSADVPTHLLLAGASENPHENPNFRFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYI7</accession>
    <name>C7YYI7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phytocyanin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_46724</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048724.1">
        <property type="nucleotide sequence ID" value="XM_003048678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYI7"/>
    <dbReference type="STRING" id="660122.C7YYI7"/>
    <dbReference type="GeneID" id="9665496"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_46724"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_46724"/>
    <dbReference type="eggNOG" id="ENOG502S0EC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043835_1_1_1"/>
    <dbReference type="InParanoid" id="C7YYI7"/>
    <dbReference type="OMA" id="IIEWRFY"/>
    <dbReference type="OrthoDB" id="2331100at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF8">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_6G00670)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988798" description="Phytocyanin domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU43011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="42654" checksum="27F8D2BAE299E3EA" modified="2009-10-13" version="1">MLPSPFVILPALLAAVWAAGGPEAPTVSGFLTETLDATSTVAEAATTASSSGAATHTVNVGASGHKFTPAEVKAEVGDVIEWRFYPSGHWIIRGDFEHPCIPYEYVDLNREGFSSGAQKVQAITDDAPRFRVRVNNTDPIFFYCGAPGSCVKWHMMGVVNPSKNETLDMWLEKAKDVDYQLRPGEPWPTEDDHPSETASPKESDREEDDEDTSSNLSPGAIAGIAIGSAAVLLLAGALLYLCGRRGGFDKAYRKSFRGTPNPPVAETQYNSPNPSGSPWDVNKPLPGVVAAPFGQSPPMSPHQSVGYGTHPATLAAMMAQAQTQDGTIGDTYTQHPAPSPSQGGTTPKPPEQTAPAELPASADPGNSPLPTYNNNNNNNNNSRSQVFSWAGEETGYRSTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZ13</accession>
    <name>C7YZ13_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase beta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">NECHADRAFT_71180</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048998.1">
        <property type="nucleotide sequence ID" value="XM_003048952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZ13"/>
    <dbReference type="FunCoup" id="C7YZ13">
        <property type="interactions" value="1111"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YZ13"/>
    <dbReference type="GeneID" id="9665659"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_71180"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_71180"/>
    <dbReference type="eggNOG" id="KOG2472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020279_2_0_1"/>
    <dbReference type="InParanoid" id="C7YZ13"/>
    <dbReference type="OMA" id="FPGRCAN"/>
    <dbReference type="OrthoDB" id="1698572at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.40.10:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000006">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000004">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000052">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
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        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040659">
        <property type="entry name" value="PhetRS_B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18262">
        <property type="entry name" value="PhetRS_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56037">
        <property type="entry name" value="PheT/TilS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="17">
        <location>
            <begin position="297"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEU43285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="609" mass="69085" checksum="3B62FD8FCAE98BA7" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZE6</accession>
    <name>C7YZE6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial carrier protein PET8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_84003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048505.1">
        <property type="nucleotide sequence ID" value="XM_003048459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZE6"/>
    <dbReference type="GeneID" id="9667582"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84003"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84003"/>
    <dbReference type="eggNOG" id="ENOG502SEH2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121514_2_0_1"/>
    <dbReference type="InParanoid" id="C7YZE6"/>
    <dbReference type="OMA" id="ETHERHK"/>
    <dbReference type="OrthoDB" id="529205at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="11209" checksum="0D2F5F337ED54035" modified="2009-10-13" version="1">MAMRTAHASRVVLGRGFFISTSSRFGLKESSTHTDFDKHKQDSLAKQKKGTGHWKPELASDSEEAVRADRSADEPAKDLQERTKRAAEETAKAGTSMRDNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0R8</accession>
    <name>C7Z0R8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_93272</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047961.1">
        <property type="nucleotide sequence ID" value="XM_003047915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0R8"/>
    <dbReference type="STRING" id="660122.C7Z0R8"/>
    <dbReference type="GeneID" id="9671946"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_93272"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_93272"/>
    <dbReference type="eggNOG" id="ENOG502SJ3K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024934_2_0_1"/>
    <dbReference type="InParanoid" id="C7Z0R8"/>
    <dbReference type="OMA" id="HRCRHVW"/>
    <dbReference type="OrthoDB" id="4937900at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU42248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="486" mass="52583" checksum="BB325B0766472198" modified="2009-10-13" version="1">MPPRSAAEAKGSGSGSGAATAKLRRAHRKSRNGCWECKRRHIKCDESRPACSNCVVSERSCSFPPSTAASAATPAAPQTPTSVPTPSPVPSHSQPPLPPSQNASGVDSQAQSPADSMSSATGLHSASGPPSSLFGSRLGFPTILDDRPPPLTALPSFTESFITNTFADSPSTPSISDGTPQPAFTAKHLILLHHATTAMSLTNDLTHPIVEIAVQWSKDGPYAMDQLLAIAADHLAILQPEHAASHRRTARELQTRALTLFNNHSQEMSQENGDLDKYCLPRFLFASLLSLHMIYETYAYYRANFHVFIERFVESVHLHRGVRTIISPCYNIVLESPLKPFLVNIRLASESDNGGSECLSLLELVQNSDLSAATVNAIAGAVHTLQWAFNVHRNLPQDGSVHAATAFPVLLTAEYMEAVRKHRPEALLVLAYYGVLLHRCPFGRSLCAGPLKSWKEIRGETGATRGHVQHCPLVPPRRTLNCTAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z101</accession>
    <name>C7Z101_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_93338</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048190.1">
        <property type="nucleotide sequence ID" value="XM_003048144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z101"/>
    <dbReference type="STRING" id="660122.C7Z101"/>
    <dbReference type="GeneID" id="9667362"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_93338"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_93338"/>
    <dbReference type="eggNOG" id="KOG0223">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020019_14_2_1"/>
    <dbReference type="InParanoid" id="C7Z101"/>
    <dbReference type="OMA" id="CFYWFIK"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000024">
        <property type="entry name" value="MIP aquaporin (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF283">
        <property type="entry name" value="AQUAPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="493"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU42477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="58948" checksum="52F513C5433BD2E9" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z299</accession>
    <name>C7Z299_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">60S ribosomal protein L16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_64318</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU41965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047678.1">
        <property type="nucleotide sequence ID" value="XM_003047632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z299"/>
    <dbReference type="FunCoup" id="C7Z299">
        <property type="interactions" value="1012"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z299"/>
    <dbReference type="GeneID" id="9671813"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_64318"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_64318"/>
    <dbReference type="eggNOG" id="KOG3204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076922_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z299"/>
    <dbReference type="OMA" id="TRFNKTH"/>
    <dbReference type="OrthoDB" id="1882297at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3250:FF:000001">
        <property type="entry name" value="60S ribosomal protein L13a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_uL13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_uL13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU41965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="22804" checksum="7CC18B5E26ADA52D" modified="2009-10-13" version="1">MSTFEQVVVIDGKGHLLGRLASIVAKQLLSGQKIVVVRCEALNISGEFFRAKLKYHAHLRKITRYNPTRGGPFHFRAPSRIFYKAVRGMIPHKTARGAAALERLKVFEGVPPPYDKKKKMVVPQALRVLRLQPGRKYCTVGRLSHEVGWKYQDIVGRLEDRRKAKAAAYYERKKIAARQLSDAKKTAAVKDETTKALAAFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z2F9</accession>
    <name>C7Z2F9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_53974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047185.1">
        <property type="nucleotide sequence ID" value="XM_003047139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z2F9"/>
    <dbReference type="GeneID" id="9676359"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_53974"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_53974"/>
    <dbReference type="eggNOG" id="ENOG502SM1S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020425_2_0_1"/>
    <dbReference type="InParanoid" id="C7Z2F9"/>
    <dbReference type="OMA" id="CWPESET"/>
    <dbReference type="OrthoDB" id="422736at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd22997">
        <property type="entry name" value="GT_LH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587:SF2">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU41472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="438" mass="49962" checksum="413A3CFFBEB677D7" modified="2009-10-13" version="1" fragment="single">KVSRLHYLVPANVVNPHVCAVVGSALANRYSIPTILGYKGEGFMDAQRAHIAKLRAIRHYLQTCRGDKDDLVIIVDGFDVMAQLPAEAMIERYFSVMAKEDQQLADQRGISVEELHASGIRQTLLWGTDKGCFPEGDNDPRCWLVPYSTLPRYKWGPMTNNGQLIYSDSRFLNSGTVIGPLGDLAIFIEAALSAIEDNWDQDYFFRDSDQYYISSLYARQEYQRLVDLNGGRFPEEVGDRSLPKNKEGEDDVTEYHVVVDFDSSFTQTQCHNNRFIHKLQFDNYDLTAHIGQDVLEEVYESLPPDDRPQMPARNWVQSLKLGTNIGTQKIYAFYHNTCDKAGFVNKYHDSWFFPLIRPLLRSAARAIREKRPIGPRPIDGRVWMPAREYPTDRGLYDEFGGVFTDMEGEEFIPLQQFCGDDLISAIGTEVEFPLSRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z2U0</accession>
    <name>C7Z2U0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Glycoside hydrolase family 28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_97800</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Pectinolytic enzyme involved in the degradation of xylogalacturonan (xga), a galacturonan backbone heavily substituted with xylose, and which is one important component of the hairy regions of pectin. Activity requires a galacturonic acid backbone substituted with xylose.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047252.1">
        <property type="nucleotide sequence ID" value="XM_003047206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z2U0"/>
    <dbReference type="GeneID" id="9676093"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_97800"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_97800"/>
    <dbReference type="eggNOG" id="ENOG502SMFC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011370_2_0_1"/>
    <dbReference type="InParanoid" id="C7Z2U0"/>
    <dbReference type="OMA" id="PMFANEH"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF9">
        <property type="entry name" value="ENDO-XYLOGALACTURONAN HYDROLASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU41539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="53678" checksum="CEA5E079C9F9E502" modified="2009-10-13" version="1">MSRISYKSPLPRGLFIIILHNASFGYAPWARHGWPAIRAVHYYPPYQRCCSTNAKVNEVNQTTGQTLSYDTSVGLFDFNGPIELSIQPSEKVYPSIETVRVRPLSYNLKADVHGRTIKLALTKPANLVVEVNGDVFRVLHLFSDEIQKDTISRDEAKKDSSILYYGAGYHELKDQVNITSGQTVYLAPGSFVKGGFNFQNASNAAILGRGVLYKSPYDAITINYSKNIRVQGVTVINPGHYSAMMGSSDGVTVSGLRSISAVKWGDGIDVFCCQNVVLEKLFMRNSDDCVAMYQHRWDYYGDSKNLTLRDSSLWADLAHPIHLGLHGNTVTPETMEDVTISNIDILDHREPQVDYQGCLAINVADENLLKNIQFQDIRVEDFRLGSLLSFKVLYNSKYSSGPGRGLHNITVKNLSYNGKGGNIPAIAGYDKDRRVEFVDFQGLEINGQHVWDGMRKPGWYSTSDFVPLYVGSHVVNLTYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z2X4</accession>
    <name>C7Z2X4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_97815</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047271.1">
        <property type="nucleotide sequence ID" value="XM_003047225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z2X4"/>
    <dbReference type="GeneID" id="9676188"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_97815"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_97815"/>
    <dbReference type="eggNOG" id="ENOG502RFSY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035427_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z2X4"/>
    <dbReference type="OMA" id="FAIEVNP"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23132">
        <property type="entry name" value="D-ALANINE--D-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23132:SF23">
        <property type="entry name" value="D-ALANINE--D-ALANINE LIGASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="4">
        <location>
            <begin position="77"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU41558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="549" mass="61949" checksum="BA8825E3238DABEF" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z321</accession>
    <name>C7Z321_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Catalase</fullName>
            <ecNumber evidence="12">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NECHADRAFT_87797</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Alkaloid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="12"/>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047469.1">
        <property type="nucleotide sequence ID" value="XM_003047423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z321"/>
    <dbReference type="STRING" id="660122.C7Z321"/>
    <dbReference type="GeneID" id="9676213"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87797"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87797"/>
    <dbReference type="eggNOG" id="KOG0047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010645_2_0_1"/>
    <dbReference type="InParanoid" id="C7Z321"/>
    <dbReference type="OMA" id="PNSYGRW"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08157">
        <property type="entry name" value="catalase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF26">
        <property type="entry name" value="CATALASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0017">Alkaloid metabolism</keyword>
    <keyword evidence="5 11 12" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 12" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="14">
        <location>
            <begin position="7"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU41756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="492" mass="55321" checksum="5771A58B9A7AE4A1" modified="2009-10-13" version="1">MSRPVYTLAEGQPLRDPSVSTTLPVFGGGGITTLGDTLLLETLAHFSRERIPERVVHAKASGAWGEFEVTNKDIAQLTCAKFLDTVGKKTRVLFRLSSTGGEKGSADTVRDVRGFSVKFYTEEGNHDIVGNHIPVFFIRDPMRFPSLNRSHKKHPATNRPDATMFWDFHVNQPESVHALMHLFGTRGLPDSIRRVTGFGVHTFKLVDSQGRFRYCKFHFRPEGGHTHFASAEDAEKEAGANPDHHNQDLWEAIARGEYPVWKLYVQIMEPEQAEAFGRALFDITKVWSHKDFPLIEVGKMTLNKNPDNYFADIEQAAFSPSNIVPGIAMTPDPMLQARMFAYPDAQRYRLGVNYTQLPSNRPIAPVYAPYERDGITVTKNYGGDPNYVRSTLSPGISSTAMAQISHHERVSPTAVLGLNEIPVDEQDYVQPRELWRRVFDEEERAQWIQTVTGALEGVPAPLRQAVVEMFSKVDPVIGQRMMAKFNENATHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z345</accession>
    <name>C7Z345_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_53821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003047262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z345"/>
    <dbReference type="GeneID" id="9675914"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_53821"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_53821"/>
    <dbReference type="eggNOG" id="KOG2317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_7_2_1"/>
    <dbReference type="InParanoid" id="C7Z345"/>
    <dbReference type="OMA" id="XGGRVEI"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF42">
        <property type="entry name" value="MMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU41595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="123" mass="13253" checksum="59A3D4B8CF73401B" modified="2009-10-13" version="1">MQVRVEGASANGLYSQALVVGNMVFLSGVTGVDPATGKLVEGTVGDRTTQIFKNISRILEAAGSSLHKVIRVNIFLTSMSDYAIMNEAYLQVLSQDVKPVRTCVAVKELPRLTDIEIEVTAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z3Z4</accession>
    <name>C7Z3Z4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Clock-controlled protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_70841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047104.1">
        <property type="nucleotide sequence ID" value="XM_003047058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z3Z4"/>
    <dbReference type="STRING" id="660122.C7Z3Z4"/>
    <dbReference type="GeneID" id="9675589"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_70841"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_70841"/>
    <dbReference type="eggNOG" id="ENOG502RG16">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015714_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z3Z4"/>
    <dbReference type="OMA" id="YSPRFKY"/>
    <dbReference type="OrthoDB" id="2441642at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013927">
        <property type="entry name" value="TF_Opi1_Ccg-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR OPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38406:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR OPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08618">
        <property type="entry name" value="Opi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU41391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="606" mass="65372" checksum="ACA41F7AFFA1D015" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z402</accession>
    <name>C7Z402_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glc8 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_70851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046942.1">
        <property type="nucleotide sequence ID" value="XM_003046896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z402"/>
    <dbReference type="FunCoup" id="C7Z402">
        <property type="interactions" value="250"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z402"/>
    <dbReference type="GeneID" id="9678681"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_70851"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_70851"/>
    <dbReference type="eggNOG" id="ENOG502S2VH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070379_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z402"/>
    <dbReference type="OMA" id="SHKSEKH"/>
    <dbReference type="OrthoDB" id="551302at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007062">
        <property type="entry name" value="PPI-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398:SF20">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY INHIBITOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398">
        <property type="entry name" value="PROTEIN PHOSPHATASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04979">
        <property type="entry name" value="IPP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU41229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="28857" checksum="C9A0F9F760131314" modified="2009-10-13" version="1">MASVVESPPVHSPPDHPAQRPRGILKNSYQKSPPTSPNQERSLTDKELTIANTQINAGHRRSSSGARPPGSRRQSGFSSIDDPLESSQRLKWDEANLYLTEQERSSTMKITEPKTPYAKHYDPSEDPSDDDEDPLANAGARLQNSRPGREDDIPGLSLGEPEEAISEAGAPSPRSEKSVHVDDESSVGHNAEEELAGMSPEEREKHRKFEQLRKRHYEMKNVAQLLGHPETIPDDEDEEDEQGNGGAVPPMPPLPRMPNGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z434</accession>
    <name>C7Z434_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-1,2-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_62613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046963.1">
        <property type="nucleotide sequence ID" value="XM_003046917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z434"/>
    <dbReference type="STRING" id="660122.C7Z434"/>
    <dbReference type="GeneID" id="9675605"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_62613"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_62613"/>
    <dbReference type="eggNOG" id="ENOG502QW40">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025462_3_0_1"/>
    <dbReference type="InParanoid" id="C7Z434"/>
    <dbReference type="OMA" id="INHWIEI"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU41250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="55339" checksum="41B3A34F20A47981" modified="2009-10-13" version="1">MSFGLQPPVLPSEVLSAICYVTIVLFAVYFIRKRKNNRGEKNLSLAASPKRSKAGQDYSDVFPPSQRPVLSSFDSRFPHADQNVETSKLSRLVLGMNEDYATASPERFIYSGFTVGDVLKLGDFPNDAALSEVPLPKPAEDFDIKTSPPRPYRPLRWPYHQTMSFQKMETDYWIELDNTYHRYIQERKDIFAKNGKNILNALPGSELACKELMEMVIQFLCARYPHYFQLDGNTFINRILGTENDLSTADPLHVLLENVPEDFAIMLRDPQTGRYHFRAGVICASTGWSLGTKLGLGLPEIHEPVPDYREKMQLSMDRFFTKMPASKPIQRGAWGFEIGQHLYIPPEDPGLRIRDSQDPSLRLEDLYFRVDWQTLRRLPLSGAIVFNFKAFFTPVTSLKDEPYVPSLSLKVISDSKENLIRYKSVWHVEHILKPALAEYERYQIDNGIMEKDWQHQTLPESPFFRGWEAKWKQLNLDSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z451</accession>
    <name>C7Z451_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_83482</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046969.1">
        <property type="nucleotide sequence ID" value="XM_003046923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z451"/>
    <dbReference type="GeneID" id="9675616"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83482"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83482"/>
    <dbReference type="eggNOG" id="ENOG502SN0C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_29_1_1"/>
    <dbReference type="InParanoid" id="C7Z451"/>
    <dbReference type="OMA" id="RRESHTT"/>
    <dbReference type="OrthoDB" id="5283415at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="164"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="508"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU41256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="518" mass="58197" checksum="695FA0EBAB0C85D2" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z492</accession>
    <name>C7Z492_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">P-type Na(+) transporter</fullName>
            <ecNumber evidence="19">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">NECHADRAFT_62632</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="19"/>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046987.1">
        <property type="nucleotide sequence ID" value="XM_003046941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z492"/>
    <dbReference type="GeneID" id="9675323"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_62632"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_62632"/>
    <dbReference type="eggNOG" id="KOG0202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_3_0_1"/>
    <dbReference type="InParanoid" id="C7Z492"/>
    <dbReference type="OMA" id="FGIDDYI"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
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        <property type="term" value="F:P-type sodium transporter activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:potassium ion transport"/>
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        <property type="entry name" value="Calcium-transporting P-type ATPase putative"/>
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        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
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        <property type="entry name" value="Plasma membrane calcium-transporting ATPase 2"/>
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        <property type="entry name" value="Sodium ion P-type ATPase"/>
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        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
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        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
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        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
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        <property type="entry name" value="HAD superfamily/HAD-like"/>
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    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
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        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
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        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CATATPASE"/>
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        <property type="entry name" value="HATPASE"/>
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        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
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    </dbReference>
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        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
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        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
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    </dbReference>
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        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="17" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="313"/>
            <end position="334"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="772"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="855"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="950"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="982"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="24">
        <location>
            <begin position="48"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EEU41274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1025" mass="110494" checksum="C45D536FA697A1EC" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4M9</accession>
    <name>C7Z4M9_FUSV7</name>
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        <recommendedName>
            <fullName evidence="4">Exocyst complex component SEC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_91134</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the exocyst complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SEC5 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EEU40951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003046618.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="nhe:NECHADRAFT_91134"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_91134"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011308_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z4M9"/>
    <dbReference type="OMA" id="RMWMDVD"/>
    <dbReference type="OrthoDB" id="26242at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029175">
        <property type="entry name" value="EXOC2/Sec5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039481">
        <property type="entry name" value="EXOC2/Sec5_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC5"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF15469">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
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    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC2/Sec5 N-terminal" evidence="6">
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            <begin position="82"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="186"/>
            <end position="205"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="566"/>
            <end position="609"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1024"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="566"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1035"/>
            <end position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU40951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1044" mass="115923" checksum="E1C7FB1B57ADAEE5" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4Z9</accession>
    <name>C7Z4Z9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RAVE subunit 2/Rogdi</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_58425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046146.1">
        <property type="nucleotide sequence ID" value="XM_003046100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4Z9"/>
    <dbReference type="STRING" id="660122.C7Z4Z9"/>
    <dbReference type="GeneID" id="9678532"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_58425"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_58425"/>
    <dbReference type="eggNOG" id="ENOG502S2HP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043442_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z4Z9"/>
    <dbReference type="OMA" id="KLNALGH"/>
    <dbReference type="OrthoDB" id="66510at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028241">
        <property type="entry name" value="RAVE2/Rogdi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618">
        <property type="entry name" value="LEUCINE ZIPPER CONTAINING TRANSCRIPTION FACTOR LZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618:SF1">
        <property type="entry name" value="PROTEIN ROGDI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10259">
        <property type="entry name" value="Rogdi_lz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU40433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="34913" checksum="A22A432713D7AECF" modified="2009-10-13" version="1">MSIAIWPSISPDELRLKAAETQARELDWIVEETLQICRDLKHGLEDCYALLAPIDPGSTLVMSTHRNEKVKGTLTRVGTRIVKGHLHLQLRTIPAQTLSLSQSDVIHIQALDSLNAYLNQSIDLLSITLSKPQDARDLASTLAILADSLSDSVALLKGPPLTDADPAWQTCSCPSYHFEPSLGPNLSFYLGLQESCIVLWLRALEPADAPVHFGTKLGLAIGTFRRLEHDEMDTVFRYNTMGSDAGGSKRGSARHTPEPRSSAADVESKDVQEVYVREKVRVESADPSLISLHSKLGFLSHMLGQARRNLSEVLSVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z524</accession>
    <name>C7Z524_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_76722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046158.1">
        <property type="nucleotide sequence ID" value="XM_003046112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z524"/>
    <dbReference type="STRING" id="660122.C7Z524"/>
    <dbReference type="GeneID" id="9678545"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76722"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76722"/>
    <dbReference type="eggNOG" id="ENOG502RS6U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015715_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z524"/>
    <dbReference type="OMA" id="DKREMQS"/>
    <dbReference type="OrthoDB" id="5091426at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="643"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="558"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU40445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="789" mass="88232" checksum="DF1F622F57733268" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z551</accession>
    <name>C7Z551_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_76747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046173.1">
        <property type="nucleotide sequence ID" value="XM_003046127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z551"/>
    <dbReference type="GeneID" id="9678279"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76747"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76747"/>
    <dbReference type="eggNOG" id="ENOG502R6HT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_628578_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z551"/>
    <dbReference type="OMA" id="VAMESQC"/>
    <dbReference type="OrthoDB" id="5095558at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU40460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="489" mass="53986" checksum="51F0F19AEBC91BE9" modified="2009-10-13" version="1">MPSPGSDFLDSLSHLFSEAGSGGRDGKIEFAHLRATLIKFVSACSRMTAAKARASHNLKFIDGSEPQTLLALPPGKLRIDEKMRAELEATTTGDEFIEILRDLITKQVSPRRSPRSRKNTSPVQTPPGSPKSKAQQRAEAAQKNKKKTVRIKLRRSGERLGTDEKEQKTQTQTQTKQTETAIESRPAISQEALARLVPKLAQLSPKPAELVPKPAELVPKSVQSVLKKAQPAPKSAPKSAPKPAPKPAPAQNLPGPMDLDANDDDDSSEGFASSESSDSSSSEDQSITYSDNGDTRMGDAVIPKVEEAAGAWPAQRRPHISEVTAAAAKCNTGGEWESFKPKLLDMLARIEADATEEEIEAALQRLEQAVIKTKSERQFIPDKTWQKYHAKLVKDAKKGWFEKNWDDRIWRIGKICYLKEEEAVMVDRNWDRLRSAAKMCAIITEMTAPPQEPNKSASIDKWLAEKLNNVTFAKKAVECREHYTAVCGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z698</accession>
    <name>C7Z698_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_76027</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045801.1">
        <property type="nucleotide sequence ID" value="XM_003045755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z698"/>
    <dbReference type="GeneID" id="9667935"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76027"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76027"/>
    <dbReference type="eggNOG" id="ENOG502SMH5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_125_13_1"/>
    <dbReference type="InParanoid" id="C7Z698"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988863" description="DUF676 domain-containing protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="10">
        <location>
            <begin position="140"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="9">
        <location>
            <begin position="437"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU40088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1086" mass="122480" checksum="AA4FA4A49FF1AEAF" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6S5</accession>
    <name>C7Z6S5_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_76197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046460.1">
        <property type="nucleotide sequence ID" value="XM_003046414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6S5"/>
    <dbReference type="STRING" id="660122.C7Z6S5"/>
    <dbReference type="GeneID" id="9668802"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76197"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76197"/>
    <dbReference type="HOGENOM" id="CLU_495293_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z6S5"/>
    <dbReference type="OMA" id="INTQAYE"/>
    <dbReference type="OrthoDB" id="5401786at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU40747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="591" mass="66594" checksum="3C32E896112C76F2" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7P6</accession>
    <name>C7Z7P6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_79511</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045577.1">
        <property type="nucleotide sequence ID" value="XM_003045531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7P6"/>
    <dbReference type="GeneID" id="9672477"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79511"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79511"/>
    <dbReference type="eggNOG" id="ENOG502SH77">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_12_0_1"/>
    <dbReference type="InParanoid" id="C7Z7P6"/>
    <dbReference type="OMA" id="ITDVMII"/>
    <dbReference type="OrthoDB" id="5401779at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF124">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="50"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="299"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU39864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="394" mass="42735" checksum="E8EE88C16339C23C" modified="2009-10-13" version="1">MSLVDGVLVAIPPPEGYVVDFDNPQRTSVEATYVICGIGMTLALFFLFQRLFVKLFVRNNFGIDDVLLIIAWVGSITIQALSLRSFAEGWMGVHGWEIPFEKFQKAILWATYINSIVYTVPTCLSKVVILLFLLELNKGQAWYRWTIFGTIFIVSASSISIFFASVFPCTPFRKSWDLNIPADVGSCIDRPAMFQATAGLGVATDVLIIAIPIPMIVGLHLSAKKKAALLCLFAIGSATVITSMVRLALLISQLDAVDTTWGGGPIHAWICVEANLLIMCACLSTLRHFVKTVAPRLLSSSRGTSTGKSKTGHSSGHELRTIGGGTGGRSANRAPYTQFDDPFTTTAEAEGGFGWRQDGKSGSLDDKSSNDDGRSDKGILQTTTMVVEYEARAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7S0</accession>
    <name>C7Z7S0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_79535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045451.1">
        <property type="nucleotide sequence ID" value="XM_003045405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7S0"/>
    <dbReference type="STRING" id="660122.C7Z7S0"/>
    <dbReference type="GeneID" id="9672489"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79535"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79535"/>
    <dbReference type="eggNOG" id="ENOG502SV98">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_598572_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z7S0"/>
    <dbReference type="OMA" id="KEWTARY"/>
    <dbReference type="OrthoDB" id="4192220at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="423" mass="48059" checksum="1D0D7AA44D189920" modified="2009-10-13" version="1">MSTILRMGGPPSPPMDRFLACHDRRAIRSITRSVTLRPSQKEGGFNTVSHKRLNTRILLLARDVIAHMEALQSFSLTTHPAEPKLMLWILRSTISTVLKALPASCVNLELVTRGGDGTRIGGNAGDPTHLCEEIRRLLPRMHHVHIDLASICDAMLGMWDSGHVFRPIKLACIRRLHINCVSMDGRKRCGGHHHDGDGDWYSGHRPPKSLWDSIIRGLQHVVELQDIDTGEITVLGSVPSGNDFNKDRYWTLLRCHVRRGHNEITTWAFPIIHITPVDENNLAWYIRVNDGAFITLDRRPLYDLVAGFPWRTLTTGPKLPAAVDPHAPRVSDEELGILSEAQWKKRYPRKIPILWLNEKKTGMRLIDAEEQEGSEMRGTVEMTPSGFVRPTEQGYFRSQVFTEEEWEHMRENVPEDGPEEESE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-03" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7V7</accession>
    <name>MAP22_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methionine aminopeptidase 2-2</fullName>
            <shortName evidence="1">MAP 2-2</shortName>
            <shortName evidence="1">MetAP 2-2</shortName>
            <ecNumber evidence="1">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">NECHADRAFT_93045</name>
    </gene>
    <organism>
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="1">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="1"/>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045472.1">
        <property type="nucleotide sequence ID" value="XM_003045426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7V7"/>
    <dbReference type="SMR" id="C7Z7V7"/>
    <dbReference type="STRING" id="660122.C7Z7V7"/>
    <dbReference type="EnsemblFungi" id="NechaT93045">
        <property type="protein sequence ID" value="NechaP93045"/>
        <property type="gene ID" value="NechaG93045"/>
    </dbReference>
    <dbReference type="GeneID" id="9672634"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_93045"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_93045"/>
    <dbReference type="eggNOG" id="KOG2775">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015857_7_1_1"/>
    <dbReference type="InParanoid" id="C7Z7V7"/>
    <dbReference type="OMA" id="ILRYHIH"/>
    <dbReference type="OrthoDB" id="7848262at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF1">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0031">Aminopeptidase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000407630" description="Methionine aminopeptidase 2-2">
        <location>
            <begin position="1"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="450" mass="49173" checksum="8584AFDFFCEB89B4" modified="2009-10-13" version="1">MGAKISEDHPPQGNGGPLSNDPCSAGGEPRGAHLSRDGDGSVGDKGGDDDDDDDEGVVGAVSLTEASDKKKKKKRKPKKKKAKKATHQSSPPRVPLSELFTPGQYPTGEFLEYEDTNTARTTAAELRALGRKQLEDPAFLDDYRRAAEVHRQVRQWAQESVKPGQTLRDIANGIEDGVRALLGNQGLEPGDGLKSGMGFPTGLCLNHETAHYTPNPGQKDVVLQYEDVMKVDFGVHINGWIVDSAFTMSFDPTYDNLLAAVKDATNSGIKVNAAIQEAMESYEVEIAGKTYPVKPVRNISAHNIQHYRIHGGKSIPFIKNSDQTKMEEGEVFAIETFGTTGRGRLYDDVGIYGYKLENGGPSPASLPFASAKKLHKVIKENFGNIVFCRRYLERLGQERYLAGLNCLVSNGLLEAYEPLADVKGSYSAQFEHTILLRESSKEILSRGSDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z876</accession>
    <name>C7Z876_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_93122</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045665.1">
        <property type="nucleotide sequence ID" value="XM_003045619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z876"/>
    <dbReference type="GeneID" id="9672432"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_93122"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_93122"/>
    <dbReference type="eggNOG" id="ENOG502S6KB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029797_2_1_1"/>
    <dbReference type="InParanoid" id="C7Z876"/>
    <dbReference type="OMA" id="TIAYNMR"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF69">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU39952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="476" mass="53189" checksum="67C15C5BBA74FB02" modified="2009-10-13" version="1">MIISGLMQDPESAAPFNPGWRMEAISACPLSKWPNAQFHSVFGLESLGSNNCSSIAVPGDKVLPLHYFDDTSVWRSFILYSLFVFEDVLDTDKIRHSLEDLARRKGWQKLGARLRRNSKGVLEYHIPADFDQDRPPIAYTHIQHDTPIADHPVASQIPKPSARPSILGDPDQFLSLMHPEGSPKKLEDYVNSERPQLGLHTVSFKDATLVSIYWPHIMFDAMGKKALLTAWSLTLQGRQGEILPLCGADSDPLTELGRHPTEVHKLADRQLSTLGLVRYGLNHITEFALRGNETRIVCVPAAFMDKLRDEAMGDVPVDSSSDEDTFLSDGDILCAWWTRIAISHLPQNSETNVILYNAYSLRSVLAGDLLPAGTSYLSNATGFIHTPLTVKEIFTKPLGYIASRIRHSISEYGTREQVEAFMSMVRQSQARTPPFFGDPSMHMLTYSNWSKAKMFETDFSAAAGLHPKLTIWLDPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z885</accession>
    <name>C7Z885_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_39574</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045538.1">
        <property type="nucleotide sequence ID" value="XM_003045492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z885"/>
    <dbReference type="STRING" id="660122.C7Z885"/>
    <dbReference type="GeneID" id="9672439"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_39574"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_39574"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_4_1_1"/>
    <dbReference type="InParanoid" id="C7Z885"/>
    <dbReference type="OMA" id="ENCTYAP"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF213">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012903797" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU39825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="647" mass="70873" checksum="0DD0F410DF2E7F3B" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8G2</accession>
    <name>C7Z8G2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_81417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045044.1">
        <property type="nucleotide sequence ID" value="XM_003044998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8G2"/>
    <dbReference type="GeneID" id="9673055"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_81417"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_81417"/>
    <dbReference type="HOGENOM" id="CLU_1687093_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z8G2"/>
    <dbReference type="OrthoDB" id="5106359at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="156" mass="17159" checksum="2AE9C1D4EF1BBEA9" modified="2009-10-13" version="1">MNNTNNSQSSPVPAVPHQLNQSQPSATTADHSPARLVNTNQTVTANQRSVSQLRQRWQLLEQQYATDIQTLASARVTAPAPATQATPALASMPQARNIGWARTFNRRVLAGRHVTATFYFDRNGDPRGYLYQHDEFILGPVNEWGGVASGYGLFPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8J9</accession>
    <name>C7Z8J9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pantoate--beta-alanine ligase</fullName>
            <ecNumber evidence="3">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pantoate-activating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pantothenate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_100842</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(R)-pantoate + beta-alanine + ATP = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="3"/>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU38966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044679.1">
        <property type="nucleotide sequence ID" value="XM_003044633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8J9"/>
    <dbReference type="FunCoup" id="C7Z8J9">
        <property type="interactions" value="232"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z8J9"/>
    <dbReference type="GeneID" id="9673514"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100842"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100842"/>
    <dbReference type="eggNOG" id="KOG3042">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047148_1_2_1"/>
    <dbReference type="InParanoid" id="C7Z8J9"/>
    <dbReference type="OMA" id="FHVDTEI"/>
    <dbReference type="OrthoDB" id="2020436at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00560">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1300.10:FF:000002">
        <property type="entry name" value="Pantoate--beta-alanine ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000013">
        <property type="entry name" value="Pantothenate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="entry name" value="Pantoate-beta-alanine ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299">
        <property type="entry name" value="CYTIDYLATE KINASE/PANTOATE-BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PANTOATE--BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU38966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="357" mass="39003" checksum="7BB830A4696F6B4B" modified="2009-10-13" version="1">MASACSSSSPVEKLPKSPIRVLRTVESFRRWRQPHVINHRSVGLVPTMGALHEGHMSLIRAAARENHHVVISIYVNPAQFGVKEDLDSYPVTWDEDARKLALLDRELADDGANLGRITAVFAPSTKEMYPSGFPGQDVDSKGSFVTITPVGEVLEGASRPTFFRGVATVCMKLFNIIQPERAYFGQKDIQQTVVLRRMLKDFLVPSQAVVCPTERDADGLALSSRNVYLGPRRRAVAIVLPGALRTAAGVYTSGGLRDRASILGAAHNFIAAVAAVQDDLPPTERSRFEVDYISLADPETMQEVDEVDPTRGAVLSGAIRMLPVEEAKEGEDLGFSGGPLVRIIDNFILEPKEAKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8Q0</accession>
    <name>C7Z8Q0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_94346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045118.1">
        <property type="nucleotide sequence ID" value="XM_003045072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8Q0"/>
    <dbReference type="STRING" id="660122.C7Z8Q0"/>
    <dbReference type="GeneID" id="9673204"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94346"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94346"/>
    <dbReference type="eggNOG" id="KOG1481">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039949_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z8Q0"/>
    <dbReference type="OMA" id="FMCCDLP"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000058">
        <property type="entry name" value="Cysteine synthase B, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="391"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="534" mass="58597" checksum="0F4EF3DD8A116D95" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9J3</accession>
    <name>C7Z9J3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">40S ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_102718</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045227.1">
        <property type="nucleotide sequence ID" value="XM_003045181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9J3"/>
    <dbReference type="FunCoup" id="C7Z9J3">
        <property type="interactions" value="783"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z9J3"/>
    <dbReference type="GeneID" id="9673463"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102718"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102718"/>
    <dbReference type="eggNOG" id="KOG1753">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046483_4_0_1"/>
    <dbReference type="InParanoid" id="C7Z9J3"/>
    <dbReference type="OMA" id="WPIEMAR"/>
    <dbReference type="OrthoDB" id="426865at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000007">
        <property type="entry name" value="40S ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001749">
        <property type="entry name" value="PRK00474.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU39514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="16111" checksum="91EDCCC8B3936074" modified="2009-10-13" version="1">MSTTQSVQCFGKKKTATAVAHCKTGRGLIKVNGRPLQLVQPEILRFKVYEPLLVVGLDKFANVDIRVRVTGGGHTSQIYAIRQAIAKSLIAYYQKFVDEHSKNLLKQALVQFDRTLLVADNRRCEPKKFGGKGARSRFQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9R6</accession>
    <name>C7Z9R6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_81846</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044859.1">
        <property type="nucleotide sequence ID" value="XM_003044813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9R6"/>
    <dbReference type="GeneID" id="9672041"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_81846"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_81846"/>
    <dbReference type="eggNOG" id="ENOG502QWTJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008241_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z9R6"/>
    <dbReference type="OMA" id="ICAHGAK"/>
    <dbReference type="OrthoDB" id="2563500at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF7">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="2"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="98"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="633"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="100"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="633"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="663"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="673"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="703"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="716"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU39146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="791" mass="88407" checksum="FE7C3916C1E43CBE" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9V2</accession>
    <name>C7Z9V2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vps72/YL1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_81881</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS72/YL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045278.1">
        <property type="nucleotide sequence ID" value="XM_003045232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9V2"/>
    <dbReference type="FunCoup" id="C7Z9V2">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z9V2"/>
    <dbReference type="GeneID" id="9672061"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_81881"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_81881"/>
    <dbReference type="eggNOG" id="ENOG502S4HA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008699_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z9V2"/>
    <dbReference type="OMA" id="PVISYWS"/>
    <dbReference type="OrthoDB" id="3942062at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046757">
        <property type="entry name" value="YL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275">
        <property type="entry name" value="YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05764">
        <property type="entry name" value="YL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="3">
        <location>
            <begin position="669"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="309"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="729"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="385"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="464"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="555"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="574"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="613"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="736"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="790"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="821"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="834"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="868"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU39565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="880" mass="94041" checksum="938DC2F93BDE3126" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZB42</accession>
    <name>C7ZB42_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_83199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044457.1">
        <property type="nucleotide sequence ID" value="XM_003044411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZB42"/>
    <dbReference type="STRING" id="660122.C7ZB42"/>
    <dbReference type="GeneID" id="9670775"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83199"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83199"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1195157_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZB42"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050466">
        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024:SF24">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024">
        <property type="entry name" value="ARYLACETAMIDE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="53"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU38744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="232" mass="25571" checksum="4752D7B3B3BA7F0C" modified="2009-10-13" version="1">MESLVRADTDGLLKQSGDQVTEREIFIPARDGSSVRALVYRSTSAPQSDLPLVVPLHDGGFCYGIEEMKAAGHIGAAHAYDCVSIDLEYRLGPGVKFPTPWEDCWDALKWLSSNASSVGANPARGFVLGGFCVSVLFSFVSPFIQDKGFGGLESRIGFLYWAISLTAAAWSLFLPEIGFRSLEELDELFQKSVSVWKFRKCQTNEYGAHLHVIEVDCDDGESKQADLEEGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBE6</accession>
    <name>C7ZBE6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_83152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044438.1">
        <property type="nucleotide sequence ID" value="XM_003044392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBE6"/>
    <dbReference type="GeneID" id="9672741"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83152"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83152"/>
    <dbReference type="HOGENOM" id="CLU_1907230_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZBE6"/>
    <dbReference type="OrthoDB" id="5091980at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU38725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="133" mass="15023" checksum="5481C1B0589F7D9C" modified="2009-10-13" version="1">MKEEDYINMMDTINAIMGHDGDQDNDPGVRKLASFHIDYPDAEMSMKLEDITCPAKLEGPISYEYLIEKQRKVVTFATEKGSVTEFIEKLSKEELHVKKLVDAIHGVLLNAKEQTDEKAVIESMAEMSLDKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBN0</accession>
    <name>C7ZBN0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_88469</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698915">
        <property type="protein sequence ID" value="EEU38545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044258.1">
        <property type="nucleotide sequence ID" value="XM_003044212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBN0"/>
    <dbReference type="STRING" id="660122.C7ZBN0"/>
    <dbReference type="GeneID" id="9670629"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88469"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88469"/>
    <dbReference type="eggNOG" id="KOG4231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003059_1_1_1"/>
    <dbReference type="InParanoid" id="C7ZBN0"/>
    <dbReference type="OMA" id="VICIFAE"/>
    <dbReference type="OrthoDB" id="4766886at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07199">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF8">
        <property type="entry name" value="PNPLA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PNPLA" evidence="6">
        <location>
            <begin position="476"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="5">
        <location>
            <begin position="480"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="5">
        <location>
            <begin position="515"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="5">
        <location>
            <begin position="659"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="517"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU38545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="932" mass="104720" checksum="C85B9B6467201359" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBS8</accession>
    <name>C7ZBS8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PD-(D/E)XK nuclease-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_88651</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698916">
        <property type="protein sequence ID" value="EEU38524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044237.1">
        <property type="nucleotide sequence ID" value="XM_003044191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBS8"/>
    <dbReference type="GeneID" id="9670498"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88651"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88651"/>
    <dbReference type="eggNOG" id="ENOG502RS7V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027219_0_4_1"/>
    <dbReference type="InParanoid" id="C7ZBS8"/>
    <dbReference type="OMA" id="AINTWRA"/>
    <dbReference type="OrthoDB" id="4161186at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046797">
        <property type="entry name" value="PDDEXK_12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20516">
        <property type="entry name" value="PDDEXK_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PD-(D/E)XK nuclease-like" evidence="2">
        <location>
            <begin position="196"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU38524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="447" mass="49819" checksum="E046BF00B8EBCBFB" modified="2009-10-13" version="1">MGSRPLIDAVTKWLENIPACDDSADSCHARDGSLSILAFKSQKRKHSHLQIPSPPVSEIQPHHHHNSIMPSQPGTPKKRKIATAPDDQVDDDTPRPLRLADKSETPSLSSLSSQSLMGGSQHSGRSSPSKLASHLRVGYHKCEATKSVASCSPTAHLPSIERLKSTSRSLALLRGSAYMDSDDIAMASPETIDARFPEKHLNDIMEIVDIAKECQGADIDETCWNNHVHSPLLHAALNRRPVPGQPISFTAYMNASMTANYRVSHIYSSKVDYAIFINPILDTPEPTNTQRAVQHLQRHSPESSVNHTGFSLLRDRPIAISIETKRYGGQERKAEFQLGSWLAAQWKLLAEQAAPEGLRELPFIPGIIVNGHEWKMVAATYADGKTKLWTNQEFGTTRSVLRTFQIVAALRRLRKWSLEEYWPWYKRYVLKIGSDEGIETIMAETSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCB5</accession>
    <name>C7ZCB5_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_34480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698918">
        <property type="protein sequence ID" value="EEU38230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043943.1">
        <property type="nucleotide sequence ID" value="XM_003043897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCB5"/>
    <dbReference type="STRING" id="660122.C7ZCB5"/>
    <dbReference type="GeneID" id="9670465"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_34480"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_34480"/>
    <dbReference type="eggNOG" id="KOG1177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_7_1"/>
    <dbReference type="InParanoid" id="C7ZCB5"/>
    <dbReference type="OMA" id="ARIGCPF"/>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF6">
        <property type="entry name" value="ACYL COA SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="43"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="484"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU38230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="591" mass="65211" checksum="FB53CDB69C67CAC6" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCF2</accession>
    <name>C7ZCF2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lactase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_123301</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="GG698918">
        <property type="protein sequence ID" value="EEU38251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043964.1">
        <property type="nucleotide sequence ID" value="XM_003043918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCF2"/>
    <dbReference type="STRING" id="660122.C7ZCF2"/>
    <dbReference type="GeneID" id="9670397"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_123301"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_123301"/>
    <dbReference type="eggNOG" id="KOG2024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002346_0_2_1"/>
    <dbReference type="InParanoid" id="C7ZCF2"/>
    <dbReference type="OMA" id="WCDHGIL"/>
    <dbReference type="OrthoDB" id="408320at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005990">
        <property type="term" value="P:lactose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000018">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050347">
        <property type="entry name" value="Bact_Beta-galactosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023232">
        <property type="entry name" value="Glyco_hydro_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032312">
        <property type="entry name" value="LacZ_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323:SF2">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16353">
        <property type="entry name" value="LacZ_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01038">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00608">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta galactosidase small chain/" evidence="7">
        <location>
            <begin position="736"/>
            <end position="1011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU38251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1011" mass="114346" checksum="7A0AA08FE1364D45" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCL7</accession>
    <name>C7ZCL7_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_77095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698918">
        <property type="protein sequence ID" value="EEU38389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044102.1">
        <property type="nucleotide sequence ID" value="XM_003044056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCL7"/>
    <dbReference type="STRING" id="660122.C7ZCL7"/>
    <dbReference type="GeneID" id="9670325"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77095"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77095"/>
    <dbReference type="eggNOG" id="ENOG502S7RC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022040_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZCL7"/>
    <dbReference type="OMA" id="SGVEMWR"/>
    <dbReference type="OrthoDB" id="5402307at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="556" mass="62748" checksum="E8AC81E09C0D9583" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZD73</accession>
    <name>C7ZD73_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transaldolase</fullName>
            <ecNumber evidence="2">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_47938</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="GG698919">
        <property type="protein sequence ID" value="EEU38041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043754.1">
        <property type="nucleotide sequence ID" value="XM_003043708.1"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZD73"/>
    <dbReference type="GeneID" id="9670248"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_47938"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_47938"/>
    <dbReference type="eggNOG" id="KOG2772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_234524_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZD73"/>
    <dbReference type="OMA" id="CFRKAPK"/>
    <dbReference type="OrthoDB" id="4850289at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF34">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0704">Schiff base</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="479"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1094"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1398"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1557"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1634"/>
            <end position="1866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1914"/>
            <end position="2121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1094"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1147"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1167"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1235"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1402"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1640"/>
            <end position="1652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1674"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1688"/>
            <end position="1699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1700"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1771"/>
            <end position="1787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1951"/>
            <end position="1962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1972"/>
            <end position="1993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="2011"/>
            <end position="2021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="2064"/>
            <end position="2080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2081"/>
            <end position="2091"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU38041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="2121" mass="238974" checksum="108053C153130C76" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDL0</accession>
    <name>C7ZDL0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">beta-glucosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_54877</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4 10"/>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043673.1">
        <property type="nucleotide sequence ID" value="XM_003043627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZDL0"/>
    <dbReference type="STRING" id="660122.C7ZDL0"/>
    <dbReference type="GeneID" id="9669585"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_54877"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_54877"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_4_0_1"/>
    <dbReference type="InParanoid" id="C7ZDL0"/>
    <dbReference type="OMA" id="WYQGQEQ"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF3">
        <property type="entry name" value="BETA-GLUCOSIDASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="11">
        <location>
            <begin position="394"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU37960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="839" mass="92741" checksum="1CEC31FD0EE6BFE4" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEA9</accession>
    <name>C7ZEA9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Short-chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_87563</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698921">
        <property type="protein sequence ID" value="EEU37631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043344.1">
        <property type="nucleotide sequence ID" value="XM_003043298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEA9"/>
    <dbReference type="STRING" id="660122.C7ZEA9"/>
    <dbReference type="GeneID" id="9669154"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87563"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87563"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_0_1"/>
    <dbReference type="InParanoid" id="C7ZEA9"/>
    <dbReference type="OMA" id="GAYIDDC"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF283">
        <property type="entry name" value="RETINOL DEHYDROGENASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU37631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="37445" checksum="39C7ED0E24D5026F" modified="2009-10-13" version="1">MTTHLKFNKTTTCEEVVEVFSENVVGKTILITGVSPNGLGEAMAQALSTKKPAKLIFTARSIAKAESVVQTIKSGMADPPLIEIVQMDLSSIASVQAAAEALQQHQHIDILINNAGVMALPDRTLSTDGYEMHFGTNFLGHWLFTNFLMPKLTSGGRVVNITSGGYMVCPIRFHDLNWDGDKELPAEEEPNMNMVQNLGLGSLANAREYNGMLAYLHSNAASMLFSVGLKERFGSKGVAAISAAPGVVVTELQRHIKGFRNPNMEYKSASQGAASFLVAALDPALQGHNGAYVDDCQMAEIVSTHVQDVEVADRTVCAGSSDLWDRVRYRADSSGTETVGPQRRLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEK2</accession>
    <name>C7ZEK2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cellulose-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_87522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698921">
        <property type="protein sequence ID" value="EEU37710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043423.1">
        <property type="nucleotide sequence ID" value="XM_003043377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEK2"/>
    <dbReference type="GeneID" id="9669135"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87522"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87522"/>
    <dbReference type="eggNOG" id="ENOG502QXBB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029266_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZEK2"/>
    <dbReference type="OMA" id="PEEPSYG"/>
    <dbReference type="OrthoDB" id="3592035at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048527">
        <property type="entry name" value="Sde182_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011483">
        <property type="entry name" value="Sde182_NH-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21027">
        <property type="entry name" value="Sde0182_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07632">
        <property type="entry name" value="Sde182_NH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cellulose-binding Sde182 nucleoside hydrolase-like" evidence="1">
        <location>
            <begin position="17"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Cellulose-binding Sde182 C-terminal" evidence="2">
        <location>
            <begin position="369"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU37710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="55401" checksum="A8FB9B00A1C1C17E" modified="2009-10-13" version="1">MATTGRSSLLPFPSKHRVFILTDITNEPDDAESFCRYLTYSNQFKTEGVVAVTSVWLRDTVAPHKLQEIVDGYEQVVDNLNAHAHPDFPYPSAQEVRGLIKSGPPVYGMAAVGDDIPLSEGGELLLERLTSSDQDPLWVLVWGGVNVLAQVLHRIRNRPDAAELRSKLRVYTISDQDDCGSWIRQQWPEIFYICSVHGWNQYGNATWIGISGSVDEGGPDPSKVTAEWVKENVQLGPLGAVYPKPAFIIEGDTPTFLYIMQNGLNFPEEPSWGSWGGRYLPANVSDKGIPNRGHFCDAADGVVGLNGTQFRTNKATIWRWRNTYQNDFAARIQWTLSPDFTKANHQPVVAVNGEFGYKPYYIEADAGSTITIDASKTYDPDGDKLSYKWFQYREPSATQTYHGYEVSELDIKEAEGSDGSKIKVTIAPPEKSCIVVREQLSLEKGLVLHLILEVTDAGTPPLTSYRRILIQPINRQYKGPGVAKKLDDEELAAMMKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEW9</accession>
    <name>C7ZEW9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_86325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043091.1">
        <property type="nucleotide sequence ID" value="XM_003043045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEW9"/>
    <dbReference type="STRING" id="660122.C7ZEW9"/>
    <dbReference type="GeneID" id="9665196"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86325"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86325"/>
    <dbReference type="eggNOG" id="ENOG502R7K3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030655_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZEW9"/>
    <dbReference type="OMA" id="YGGPEGW"/>
    <dbReference type="OrthoDB" id="3257981at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029167">
        <property type="entry name" value="Mug117"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15474">
        <property type="entry name" value="MU117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU37378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="602" mass="66332" checksum="981EAE89084FB604" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZF40</accession>
    <name>C7ZF40_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_86381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043213.1">
        <property type="nucleotide sequence ID" value="XM_003043167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZF40"/>
    <dbReference type="GeneID" id="9665318"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86381"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86381"/>
    <dbReference type="eggNOG" id="ENOG502RN9T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_591890_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZF40"/>
    <dbReference type="OrthoDB" id="3766406at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU37500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="48758" checksum="0B7648A1512A0F9A" modified="2009-10-13" version="1">MIDMIPLTVYAARLLIWAIRPARTIESHVSKSGKKDLRVVPKPRNPFNILPNELLMDIADLLDPADKASFAYTDRRAYCCTGKLDFLHPEDKIQFLTRLDREGFMPFDILCHVCAKFHPPRGDRWWNDAEGQRECILDGNSEVIQQGYLDSPFLPYHVYFDIVAAVCRSFRLKNGNYIVNCLADRNVYKTKGAKISSRTSARFCEGRFGEGQLILKTENVLLLQPGPDLSQNVANLNDLLYENWWLTGVCGHVSWDMIWPYIFNPEEESPDVKIYNHVLSKDTTTLPVLDGWDMSSCVWEAPIGCWTWTVDVISPFAEWHCDELWTCAKCSTNFKISVVRRPSDPLANAIVFTSWKELGKGVSLSDENWRAHMDTFDTVEYEEYPPQVWQNMAAMAFEGIEGLGTNFTYVPDLGDVLEELDKIDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZF53</accession>
    <name>C7ZF53_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_86394</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043221.1">
        <property type="nucleotide sequence ID" value="XM_003043175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZF53"/>
    <dbReference type="STRING" id="660122.C7ZF53"/>
    <dbReference type="GeneID" id="9665225"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86394"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86394"/>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_475736_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZF53"/>
    <dbReference type="OrthoDB" id="10252009at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040410">
        <property type="entry name" value="UPF0658_Golgi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391:SF1">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="404"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="464"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU37508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="573" mass="62925" checksum="A24908E2454B46C7" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZF88</accession>
    <name>C7ZF88_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_78380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698923">
        <property type="protein sequence ID" value="EEU37179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042892.1">
        <property type="nucleotide sequence ID" value="XM_003042846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZF88"/>
    <dbReference type="STRING" id="660122.C7ZF88"/>
    <dbReference type="GeneID" id="9665102"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78380"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78380"/>
    <dbReference type="eggNOG" id="ENOG502SICY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002639_3_2_1"/>
    <dbReference type="InParanoid" id="C7ZF88"/>
    <dbReference type="OMA" id="WIENCSH"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF8">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="213"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="705" mass="77901" checksum="7BC401415CFC8C80" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFC0</accession>
    <name>C7ZFC0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_37090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698923">
        <property type="protein sequence ID" value="EEU37314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043027.1">
        <property type="nucleotide sequence ID" value="XM_003042981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFC0"/>
    <dbReference type="GeneID" id="9665073"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_37090"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_37090"/>
    <dbReference type="eggNOG" id="ENOG502QSKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_2_3_1"/>
    <dbReference type="InParanoid" id="C7ZFC0"/>
    <dbReference type="OMA" id="YEYHMIN"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF105">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="33514" checksum="189C3F5139812A1C" modified="2009-10-13" version="1" fragment="single">DELSTASLRSSIRDYHMINGRGYHRDESKSESNQYYLPSDEAYGNLADLQNHQLLLTFGGKRYFAPNAETAKRVLDVGTGTGVWAVGFADDHPHAQVFGIDIAAIQPTFVPPNCTFEIEDAEKDWTWSEKFDYIFVRLMVGSLADWDKFTRKCFENLEPGGWLEVIDPTFPAKSDDGTLKPTSPLNKWDELTSKGAANLGRPFDEGVNHEKRLKEQGFVNVTRKTFKWPINTWPKDPKYKEVGLWTLANIERNLEAISTILLAHGLGMSQDGILVFLSEVRAEMRNPRVHAYWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFX4</accession>
    <name>C7ZFX4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Luciferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_97337</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698924">
        <property type="protein sequence ID" value="EEU37053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042766.1">
        <property type="nucleotide sequence ID" value="XM_003042720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFX4"/>
    <dbReference type="GeneID" id="9664882"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_97337"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_97337"/>
    <dbReference type="eggNOG" id="ENOG502QSR6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022256_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZFX4"/>
    <dbReference type="OMA" id="HGLKEQI"/>
    <dbReference type="OrthoDB" id="5561043at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF41">
        <property type="entry name" value="XENOBIOTIC COMPOUND MONOOXYGENASE, DSZA FAMILY (AFU_ORTHOLOGUE AFUA_3G15040)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="3">
        <location>
            <begin position="37"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="452"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU37053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="481" mass="53391" checksum="9095FBA3F450F03E" modified="2009-10-13" version="1">MAANSSHKKQIILNAFVMNTPGHLAPGLWRHPRNKTDQYKKLSFWTELAQLLDKADFHAMFIADTLGPYDVYKGPANVVPVLNSGAQYPVNDPLYLVPALAAATKNLIFGVTASLTYEKPYALARRLSTVDHLSEGRVAWNIVTSYLDSAARNHGLDEQIPHDERYAIAHEYLEVLYKLWEGSFRDDAVLADRESGTYIASDAVRQIHHKGKYFQVPGPHFVEPSPQRTPFLFQAGVSEAGNGFGGKHGEAIFVGGQTPESVRKTVDNIRAIAAKEGRDPNHIKIIVGIAVIVAATDEEAKAKRDEYLSYADTEGALALFGGWTGIDLSGYSDDEDFRMTEAPRIRSILRRWSDTVPGTDNLPWTKRRIAEYISIGGLGAKIIGSPTTVADELEHWVEVADVDGFNLSHIVNPGSFEDIIEFLLPELRRRGVFRSGVDKEGATAREVFIGSKRLPEDHPGSKYKWRAGEEASPFLEEEHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZGT2</accession>
    <name>C7ZGT2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline monooxygenase, chloroplastic</fullName>
            <ecNumber evidence="5">1.14.15.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_55718</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the first step of the osmoprotectant glycine betaine synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>choline + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = betaine aldehyde hydrate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:17769"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15870"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.14.15.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (monooxygenase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the choline monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.7" evidence="5"/>
    <dbReference type="EMBL" id="GG698926">
        <property type="protein sequence ID" value="EEU36752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042465.1">
        <property type="nucleotide sequence ID" value="XM_003042419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZGT2"/>
    <dbReference type="STRING" id="660122.C7ZGT2"/>
    <dbReference type="GeneID" id="9669814"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55718"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55718"/>
    <dbReference type="eggNOG" id="ENOG502QQJW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026244_1_2_1"/>
    <dbReference type="InParanoid" id="C7ZGT2"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="UniPathway" id="UPA00529">
        <property type="reaction ID" value="UER00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019133">
        <property type="term" value="F:choline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019285">
        <property type="term" value="P:glycine betaine biosynthetic process from choline"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00680">
        <property type="entry name" value="RHO_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03469">
        <property type="entry name" value="Rieske_RO_Alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF5">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="13">
        <location>
            <begin position="19"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU36752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="387" mass="44840" checksum="4E2F9B06A4F85DC4" modified="2009-10-13" version="1" fragment="single">YREPGFYELERRAIFSKSWILISHSCQFNEPGKYARYEMAGYPFFIIRDRARSVNAFLNVCRHRAFPIVHEDAGKVMVLSCKYHGMSRLKSYSMNGNLAKAPRFDQVEGFQKDDYKLYKVHTHIDDLGFLWVNLDATEKPTLSWEEQFGGVDKQPRLSNFDMSNYEYDHTWSMEGKFNWKTLIENYNECYHCPTAHPGLAPFFRNNRQMVYGCHKYWVEHLGGKGEERSSSVSPTYMFPNASVTLTPVFFYMMSIVPTSATTSLMRYEVYRAKNATKEQLQEKLDFFAQVEGEDKWLANGSQANLNNDTYTTGPFHPDVEQGVTYITGLVKKILHNHFDEEKKRGQEWWPARRALAQSSSEEDKAFCRGVCGHSVLNGNNAPEGLSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZIS7</accession>
    <name>C7ZIS7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Multicopper oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_53037</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698931">
        <property type="protein sequence ID" value="EEU36078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041791.1">
        <property type="nucleotide sequence ID" value="XM_003041745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZIS7"/>
    <dbReference type="STRING" id="660122.C7ZIS7"/>
    <dbReference type="GeneID" id="9674118"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_53037"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_53037"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_7_2_1"/>
    <dbReference type="InParanoid" id="C7ZIS7"/>
    <dbReference type="OMA" id="HGHHFYI"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04205">
        <property type="entry name" value="CuRO_2_LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13910">
        <property type="entry name" value="CuRO_3_MCO_like_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="11">
        <location>
            <begin position="108"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="189"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="453"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU36078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="582" mass="64912" checksum="F87A43CB0A86F6A1" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJM9</accession>
    <name>C7ZJM9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_82172</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698935">
        <property type="protein sequence ID" value="EEU35731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041444.1">
        <property type="nucleotide sequence ID" value="XM_003041398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJM9"/>
    <dbReference type="GeneID" id="9676298"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82172"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82172"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006937_8_1_1"/>
    <dbReference type="InParanoid" id="C7ZJM9"/>
    <dbReference type="OMA" id="TWSHLYR"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF5">
        <property type="entry name" value="DUAL-FUNCTIONAL MONOOXYGENASE_METHYLTRANSFERASE PSOF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU35731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="60432" checksum="06ADBF23D8A9F2E9" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJU0</accession>
    <name>C7ZJU0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Quinate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_54387</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698936">
        <property type="protein sequence ID" value="EEU35688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041401.1">
        <property type="nucleotide sequence ID" value="XM_003041355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJU0"/>
    <dbReference type="GeneID" id="9676275"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_54387"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_54387"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="InParanoid" id="C7ZJU0"/>
    <dbReference type="OMA" id="CWIRQLE"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF34">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="24"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU35688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="535" mass="60053" checksum="78013216F84FEEEA" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKK9</accession>
    <name>C7ZKK9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_51238</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698940">
        <property type="protein sequence ID" value="EEU35426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041139.1">
        <property type="nucleotide sequence ID" value="XM_003041093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKK9"/>
    <dbReference type="FunCoup" id="C7ZKK9">
        <property type="interactions" value="569"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZKK9"/>
    <dbReference type="GeneID" id="9675700"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51238"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51238"/>
    <dbReference type="eggNOG" id="KOG3857">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007207_0_1_1"/>
    <dbReference type="InParanoid" id="C7ZKK9"/>
    <dbReference type="OMA" id="HAMSHQV"/>
    <dbReference type="OrthoDB" id="3360544at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018506">
        <property type="term" value="F:maleylacetate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08177">
        <property type="entry name" value="MAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034786">
        <property type="entry name" value="MAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF105">
        <property type="entry name" value="REDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="3">
        <location>
            <begin position="9"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="4">
        <location>
            <begin position="163"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU35426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="356" mass="37697" checksum="BD9276C85414D72E" modified="2009-10-13" version="1">MDFEYNANPARVIFGSGTIQKLPSELSKLGASRPLLLSTPHQTAQAQDVSNILQGKIAAVFSEARMHTPTDVTQRACDLATSSKADALISIGGGSTIGLGKAISIRTGLPHIAIPTTYAGSEVTPILGETADGRKETRSDPKILPRVVIYDVDLTLTLPVGLTATSGVNAIAHAVEALYARNSNPIISLLAVEGVKALATSLPELIRDPTSKSARSSALYGAWLCGTCLGSVGMSLHHKLCHTLGGSFDLPHAETHTIVLPHALSYNAPKVPEAMKLLAEALPESNGDAIKGLNVLLGKIKVERSLKALGMKASDVEKAADIAISKPYWNPREVERMAIREVIRRAWAGEDARADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKP0</accession>
    <name>C7ZKP0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc knuckle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_86220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698940">
        <property type="protein sequence ID" value="EEU35477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041190.1">
        <property type="nucleotide sequence ID" value="XM_003041144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKP0"/>
    <dbReference type="GeneID" id="9675720"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86220"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86220"/>
    <dbReference type="eggNOG" id="ENOG502RJ8U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_552185_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZKP0"/>
    <dbReference type="OMA" id="LARNEMC"/>
    <dbReference type="OrthoDB" id="4777753at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="53227" checksum="B3C686FF78D9CBCD" modified="2009-10-13" version="1">MPGKGENKSQAGKDKEDMRDVVSGSGEAGRNSSTLGGSSSSHSQVQARPGGDALGPTILPPNSLELRSLTNNVGQTLGSGFHNKRGGPVRNVISATDELVPDSLSFQGTMETLYSAGLLVQASIGENETDQIAGFIFKARTDFISRNPRQPEKSGLTVVSGGSGVRVPREGKYIEMRETSEALAREQEEAADERVKPPKPEVKCGGCGSKTHELFNCLKTAPNGLMKGCPKCNTIEHDIDGCPKLTDINNRFRFLVTGRGHMPAFATKKMEFHWAAVFCEWRAKQDSLGRRRRRDPRLPWTPEFTLQQGEAKIQEYQRKLDEDGFTGARLPADPATRDWDSASKTYPTRLPRSQAQPVQAQQVQAQQIQAVRALAQDIIKDNPAARVPGAAAAAAVNKGPSTEVEIDDLLDEIFDEDEDSPAVEAGSTQGGTKDVQMEDAPAAEGTKPEETKSGETTDTEDGSGDEKSGGEEDGLEESDAGSNLGDDKVDWSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKY4</accession>
    <name>C7ZKY4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein-sorting-associated protein 46</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_67766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698942">
        <property type="protein sequence ID" value="EEU35279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040992.1">
        <property type="nucleotide sequence ID" value="XM_003040946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKY4"/>
    <dbReference type="FunCoup" id="C7ZKY4">
        <property type="interactions" value="683"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZKY4"/>
    <dbReference type="GeneID" id="9675506"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_67766"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_67766"/>
    <dbReference type="eggNOG" id="KOG3232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125118_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZKY4"/>
    <dbReference type="OMA" id="QQITMVM"/>
    <dbReference type="OrthoDB" id="10266568at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="23134" checksum="09EA8DA91A612F1A" modified="2009-10-13" version="1">MSNRQQARDMQVEFQARFQAKQARREAQKAAKQDPILKKQIQDLLKKGETQKAYQKAKMLLSKQALAQQMDQMADMAELSAAQIQANNAMNRMTHMMASSSRTMNMAQKSTNPEKTLVTLEQFKQQNEEYAMSNGIYQDAITQSTSTQVGEDAVHELLGKLADDAGLELSKELSQATPSTAEPQQANEPTAEEEDKLQQRLRALRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZL04</accession>
    <name>C7ZL04_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_78279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698942">
        <property type="protein sequence ID" value="EEU35289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041002.1">
        <property type="nucleotide sequence ID" value="XM_003040956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZL04"/>
    <dbReference type="GeneID" id="9675395"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78279"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78279"/>
    <dbReference type="eggNOG" id="ENOG502T5IJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1503833_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZL04"/>
    <dbReference type="OrthoDB" id="4778315at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="179" mass="19305" checksum="F8E3970732B7BB67" modified="2009-10-13" version="1">MNGTESPESQKPPPSSAGTNGHASTNSSLAAKKRKKDGLKPIITMEGASPHPAIGQAPFQRLVRGRSAATHGAVLHHITEDGSGQRSRLKRVWTLLTQPLAPPANDGWDSGAWDSHPRHVPWVWWLAMVQDANVMVWHSQGGGAHARYHLTDRCRHSAFCHAAACSLVFAGFSVAGWTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLE2</accession>
    <name>C7ZLE2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_53207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698944">
        <property type="protein sequence ID" value="EEU35178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040891.1">
        <property type="nucleotide sequence ID" value="XM_003040845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLE2"/>
    <dbReference type="STRING" id="660122.C7ZLE2"/>
    <dbReference type="GeneID" id="9675222"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_53207"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_53207"/>
    <dbReference type="eggNOG" id="ENOG502SK4Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066707_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZLE2"/>
    <dbReference type="OMA" id="LARWMFE"/>
    <dbReference type="OrthoDB" id="63935at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004074">
        <property type="term" value="F:biliverdin reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="28891" checksum="16C5172D33EC1BC2" modified="2009-10-13" version="1">MGVKAAFIGASGATLSHVLTWTLLAGYNAAALVRDASKLRKILTENNVSEEILVSHLAIVEGSSRDITAVSNLLRHEPDIIFTGITSLPSFHWNPLRPISMQDATITGDSAAAVVESLRELKASKAISKSPVFVPISSTGHGTQRDQPLLLIPLYLWLLPVAQADTGVLERVVREAATEDNSPFGGYVMLRPPLLTHGRMKGTASLRVGWVWEDDTYRNLDEVEQGIEVGYTISRGDLARWIFEQLVQDDIKKWEGKCVNITY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLJ3</accession>
    <name>C7ZLJ3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_88696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698945">
        <property type="protein sequence ID" value="EEU35126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040839.1">
        <property type="nucleotide sequence ID" value="XM_003040793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLJ3"/>
    <dbReference type="GeneID" id="9679254"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88696"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88696"/>
    <dbReference type="HOGENOM" id="CLU_1713768_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZLJ3"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU35126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="153" mass="17178" checksum="72C06AF9E70E0589" modified="2009-10-13" version="1">MKMTKFFEKDKPWDSCGDGTLDDPEVFLLSSSLYTATVDSAVDHLAKAARGPKSEGRNRAGLSPPGYSRVPYSRLAAADGQLLEGHVYCVIDGQSGKFMAREARKHARDGQDQPVQLHNFDLRPKRRTKLVSRLLQDYEAWRKIQGPLFQQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMK0</accession>
    <name>C7ZMK0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycoside hydrolase family 88 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_25773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 88 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698953">
        <property type="protein sequence ID" value="EEU34785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040498.1">
        <property type="nucleotide sequence ID" value="XM_003040452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMK0"/>
    <dbReference type="GeneID" id="9678924"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_25773"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_25773"/>
    <dbReference type="eggNOG" id="ENOG502S0YB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027158_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZMK0"/>
    <dbReference type="OMA" id="RLAKSWY"/>
    <dbReference type="OrthoDB" id="2317065at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052757">
        <property type="term" value="F:chondroitin hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052369">
        <property type="entry name" value="UG_Glycosaminoglycan_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36845">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36845:SF1">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU34785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="42478" checksum="0DDC15B362FC7DD6" modified="2009-10-13" version="1" fragment="single">VERAWKLASKVLTRHDAPDLFPHFTFPSLGYYIWNDSTFWTSGFFPGIVWSLYERSLMTPLSVAPSKDLLRAAQTWQIEMAKEQFKTDNHDLGFMIMPSFARDYDLTGNRASLDVVVNAARSLASRFSPTTGTIRSWAGARTKTYNLHDEDVDFVVVIDSMMNLDLLYYAAHHTGDKSLADIATTHATTTLANHIRPDYSSYHLVSYDPHRQGVVRHRLTNQGYANESTWARGQSWALYGFATVYQWTRDERFLDAAIEIAKYFLSRVDESNGIDTIVYWDFDAPRPGVWDVSAAACASSGLLLLQQLAPKRCNCLESVLRILDTVTTRATSKGDCLLERSTANDHVHALHRLAEHGVVYADYYFLEAGNRLLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMQ8</accession>
    <name>C7ZMQ8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3500 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_52758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698957">
        <property type="protein sequence ID" value="EEU34714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003040381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMQ8"/>
    <dbReference type="GeneID" id="9678850"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_52758"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_52758"/>
    <dbReference type="eggNOG" id="ENOG502R8TZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033093_2_1_1"/>
    <dbReference type="InParanoid" id="C7ZMQ8"/>
    <dbReference type="OMA" id="PAKYHTH"/>
    <dbReference type="OrthoDB" id="4539697at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021889">
        <property type="entry name" value="DUF3500"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37489">
        <property type="entry name" value="DUF3500 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37489:SF1">
        <property type="entry name" value="DUF3500 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12006">
        <property type="entry name" value="DUF3500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU34714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="47821" checksum="5553D3D9C49A8335" modified="2009-10-13" version="1">MEPKRPVAGFRNYIPPKDVPRSKELAASDTYQWAKLRCSEPFMIGWMKAWEELYHQPYKGITVDGHVIPNIYHLADTEEDFGAPVVQMTTAAQHAIDVASAEERKALLQPVDAPEWRSWINPEIYAFRHGVRLEEASKELVAGLHALMRASLSPAGYEKAHGCMKVNQFLGEVVDGTKVLNENSYNFVIFGTPLVNEPWGWQLFGHHLCMNCFVVGKQMVISPVFMGAEPNVIDAGPNKGVELFIDQEQTALHLMQSLDPAIQKAAQIYTKLNGSEFPAWRHHRADQRHLGGAFQDNRVVPYEGVKVTTLSEAQQSVIRKIVAMSLNYLPEKVLEARMQDISAHWDETWFCWIGGFEDGDAFYYKVHSPVVMVEFDHHSGVFLNNKEPLPFHIHTLVRTPNGNDYGKKLLEQYQQRKGNAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMX6</accession>
    <name>C7ZMX6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_34803</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698959">
        <property type="protein sequence ID" value="EEU34659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040372.1">
        <property type="nucleotide sequence ID" value="XM_003040326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMX6"/>
    <dbReference type="GeneID" id="9678785"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_34803"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_34803"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_2_3_1"/>
    <dbReference type="InParanoid" id="C7ZMX6"/>
    <dbReference type="OMA" id="TWINSTG"/>
    <dbReference type="OrthoDB" id="2417308at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF22">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="533"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="543"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU34659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="554" mass="59759" checksum="BD3C9433A0587CBD" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZN31</accession>
    <name>C7ZN31_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_55774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698961">
        <property type="protein sequence ID" value="EEU34584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040297.1">
        <property type="nucleotide sequence ID" value="XM_003040251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZN31"/>
    <dbReference type="GeneID" id="9678733"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55774"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55774"/>
    <dbReference type="eggNOG" id="ENOG502T0YA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_976713_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZN31"/>
    <dbReference type="OMA" id="SCGQRCK"/>
    <dbReference type="OrthoDB" id="3778483at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU34584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="321" mass="37277" checksum="9BE510089221B1C3" modified="2009-10-13" version="1">MQRLLSSQETQPKASPTTIRTAYIRTILDSEVKYYEHDWSNLTTWLWFWVGQEVPKDPFQNDDRGQSQSPPDIHHHYILLHRNAADAFVLEWLLRNSEPEGWRLARDNFTVYLSRRQMNEPANKLLLHHLGSMRVALPQSTEYASGDICDTAMFSKSDYVLETSLVRGAGCATTFDTLFRNSMRHGCPQQYRTEEKSSAYYANRLKGRMGHTQRYCGYPHGKSEAWKQEHEKEWKSYKCPSCGKRCKRSKGCKSTGEFWTKDEGTWVDIAVASAARPPEFEKEWRALSVEDVINNHGLDATVAERLKHWKWRSIDTFSGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNA9</accession>
    <name>C7ZNA9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_73192</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698965">
        <property type="protein sequence ID" value="EEU34490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040203.1">
        <property type="nucleotide sequence ID" value="XM_003040157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNA9"/>
    <dbReference type="STRING" id="660122.C7ZNA9"/>
    <dbReference type="GeneID" id="9678026"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_73192"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_73192"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="InParanoid" id="C7ZNA9"/>
    <dbReference type="OMA" id="EAWKMHD"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000085">
        <property type="entry name" value="Dihydroflavonol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU34490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="347" mass="38261" checksum="0C1527AD8FD9250E" modified="2009-10-13" version="1">MSKSLVTGGTGFIGLYVVKLLLERGHHVNTTVRNLENTTKCKPLLDLQAKYSTKLKLFEADLMEHGSFRQAMEGCEVVYHIASPFLVPQQIKDGLKECVEPALQGTKNVLQSANDVESVKRVVLTSSVAATYGDNADVLKVKDQTLSESCWNETSSVSYAPYAYSKTVAEREAWEIHSLQNRWSLVVINPGMVLGPSMTSESVSGSLFMLEAMYRGENRMGCADLSWPLVDVRDVAEAHVKVGANTATKGRYIISGDHTISLLEMANLVRPIHQNPKVLPCWNLPKLMVYAAGPFIGISKKWSDANMGIGFKVDNSKSIKELGMAYRSAEEAVQEHYKSWLKNAKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNF4</accession>
    <name>C7ZNF4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_44529</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698967">
        <property type="protein sequence ID" value="EEU34462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040175.1">
        <property type="nucleotide sequence ID" value="XM_003040129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNF4"/>
    <dbReference type="GeneID" id="9677990"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_44529"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_44529"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_1"/>
    <dbReference type="InParanoid" id="C7ZNF4"/>
    <dbReference type="OMA" id="QECRKYL"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF13">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU34462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="262" mass="28236" checksum="446365ED6E72BBEB" modified="2009-10-13" version="1">MSQTKVALVTAASSGLGAAIARMLAVDLGMNVVINFNSNASRAEDLVKSIQDEFNATHIEGRVSVQSIQADMCDKSQVKSLVTDAAARFGDRLDIVISNVGWTRMRNFSDLEDNVDEDDWDRCFTANVKSHLWLFHAAKKYLEESNLRDAGGAAFVSTASLAGVKPSGSSVPYAVTKSAQIHLGRCLATLAAPSIRVNTISPGILLTEWGLSFPAQRLELARKSNKLDRFATVEDVVQQVKTFVVSKSVTGQNAVIDAGFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNP9</accession>
    <name>C7ZNP9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_85466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039741.1">
        <property type="nucleotide sequence ID" value="XM_003039695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNP9"/>
    <dbReference type="GeneID" id="9677863"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85466"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85466"/>
    <dbReference type="eggNOG" id="ENOG502SMHN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051118_2_1_1"/>
    <dbReference type="InParanoid" id="C7ZNP9"/>
    <dbReference type="OMA" id="YINDMAS"/>
    <dbReference type="OrthoDB" id="5342093at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF5">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="2">
        <location>
            <begin position="9"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU34028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="274" mass="30598" checksum="9F056043B4FA080E" modified="2009-10-13" version="1">MSQPKPAGYQKLAALMGRTNDLGVFRKFTRLNMLSLLSLQAELVELEADYGDICEDDVQGGEKFHLSFQELRNSREKPNSFQYEKLQEIRARLGEYMASLLDLKPPSKKNVAVLREWLNDAKGGDEFLQGLERSQWDTVVDSDLVALHKVADNEDVFARCFRKATIHIYHRLWGHKGHGGIVIDEESGMVEYSDTKVGQVSQAVSTTLASILPVLAVLGLYFEKNLLNRIYIMIGITTIFAAVLSVFSRVSRAEIFSATATFAAVEVVFIGSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNU0</accession>
    <name>C7ZNU0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_85540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039967.1">
        <property type="nucleotide sequence ID" value="XM_003039921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNU0"/>
    <dbReference type="STRING" id="660122.C7ZNU0"/>
    <dbReference type="GeneID" id="9677902"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85540"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85540"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_34_23_1"/>
    <dbReference type="InParanoid" id="C7ZNU0"/>
    <dbReference type="OMA" id="ANHEPEN"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="126"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="3">
        <location>
            <begin position="412"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="669"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="714"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU34254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="785" mass="86934" checksum="5BB3E6C479F12EE9" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNZ4</accession>
    <name>C7ZNZ4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">transketolase</fullName>
            <ecNumber evidence="4">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">NECHADRAFT_49818</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit. During the reaction, the substrate forms a covalent intermediate with the cofactor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039717.1">
        <property type="nucleotide sequence ID" value="XM_003039671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNZ4"/>
    <dbReference type="STRING" id="660122.C7ZNZ4"/>
    <dbReference type="GeneID" id="9677628"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_49818"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_49818"/>
    <dbReference type="eggNOG" id="KOG0523">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZNZ4"/>
    <dbReference type="OMA" id="MTWCMVG"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000004">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000012">
        <property type="entry name" value="Transketolase, variant 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049557">
        <property type="entry name" value="Transketolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF6">
        <property type="entry name" value="TRANSKETOLASE-LIKE PYRIMIDINE-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="15">
        <location>
            <begin position="390"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="457"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="151"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="11">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="509"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="521"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="568"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEU34004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="738" mass="80718" checksum="A305C8D34BC224A1" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZP83</accession>
    <name>C7ZP83_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_85629</name>
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    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
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        <dbReference type="NCBI Taxonomy" id="660122"/>
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            <taxon>Pezizomycotina</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZP83"/>
    <dbReference type="GeneID" id="9677543"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85629"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85629"/>
    <dbReference type="HOGENOM" id="CLU_057547_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZP83"/>
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    <dbReference type="OrthoDB" id="4500473at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU34302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="274" mass="29836" checksum="BF16D7F8E982B253" modified="2009-10-13" version="1">MVVTTPTYHIISRVPPPPQGPLKLGTVIDSLEELIPLSDSLDVEGSRVTQFREEDFEVNRAQILKGAGGVGFKVLGMPVGIDISGGGDTAVNDTYKFKELDTVSFNPTPDDYQKAVAASQLQDYLEDSGYTPVYIVTGMKIGHRPEVTLRRGNQVNGTFTIGISDGNATLGTNANASSSSNIVQGSKSSPDSIVFAIRVRKLSFTKRYYIWGPRKLRNDPYNCSAELVGVGREADKSSEPAIFDVKEMDLDEEILGRATQERGNSQEGRFILVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPR5</accession>
    <name>C7ZPR5_FUSV7</name>
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        <recommendedName>
            <fullName evidence="8">GATA-type domain-containing protein</fullName>
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    <organism evidence="9 10">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
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                <person name="Temporini E."/>
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            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003039652.1"/>
    </dbReference>
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    <dbReference type="STRING" id="660122.C7ZPR5"/>
    <dbReference type="GeneID" id="9677529"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88991"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88991"/>
    <dbReference type="eggNOG" id="KOG1601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029475_0_1_1"/>
    <dbReference type="InParanoid" id="C7ZPR5"/>
    <dbReference type="OMA" id="HYATRAH"/>
    <dbReference type="OrthoDB" id="5084853at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172:SF24">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172">
        <property type="entry name" value="OS01G0976800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="372"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="67"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="134"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU33985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="425" mass="47334" checksum="5073AC83ECCA9706" modified="2009-10-13" version="1">MAMTMLIMPSTHHPLRPSVSSDYHHSSSGASISNMISSVVPQKPANGNNSSNRRPLFSISELIQDAKLGPPLPGSPSSTRPGSKLSSSFEPVPRSFSKAGKHSSPQPLHPASSFPSQQYALTSFTSSHRLPLTSRPLLPPLSDCQAGLSAKPDIPPQQHHPQEQRPPRAHYPFNVVYAHPHPPPPPTSAIYQPGQQPPSQMRLPVSRISPKHAVPPHVSRPYNPWEPPDTEKGVCAPRARHDATVTKHFESWSYQDSLSQIGSCSHKILNFSEVYTRITQEQHGAHPIPSRLPTEQDISDMLGNIERIKRHLEQVRSLLQALSQNERAREAAKMKSPYEEDHDVPMHGDAMKPQYSMTEANTRLRCAAPLDRCHSCNRVDTPEWRRGPDGARTLCNACGLRYAKLKKQQLEARSIHVKHREAHSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPT6</accession>
    <name>C7ZPT6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_88030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698973">
        <property type="protein sequence ID" value="EEU33956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039669.1">
        <property type="nucleotide sequence ID" value="XM_003039623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZPT6"/>
    <dbReference type="GeneID" id="9677502"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88030"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88030"/>
    <dbReference type="eggNOG" id="ENOG502SNT2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003487_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZPT6"/>
    <dbReference type="OMA" id="QCTQRSV"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="95"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="28"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU33956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="819" mass="90239" checksum="FA7812A3F62642F4" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPX3</accession>
    <name>C7ZPX3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6570 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_55879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698975">
        <property type="protein sequence ID" value="EEU33917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039630.1">
        <property type="nucleotide sequence ID" value="XM_003039584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZPX3"/>
    <dbReference type="GeneID" id="9667158"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55879"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55879"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148403_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZPX3"/>
    <dbReference type="OrthoDB" id="5088358at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="1">
        <location>
            <begin position="66"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU33917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="147" mass="17244" checksum="9F3BDD06BA66A18C" modified="2009-10-13" version="1" fragment="single">FIGDLDLPALSEEDWALVREFYTALNDDKMHSCICCREYWFDMKKNSLGVCSRCISRDRERTADEPYFFSAANSLDFGEVPGNLPSLMIVKEMLIARVYVYVKYKYRGHVVHFLRNVGRLFEELLVLPEELDIVLLWPLNMEGDPYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQ30</accession>
    <name>C7ZQ30_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_55916</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698981">
        <property type="protein sequence ID" value="EEU33875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039588.1">
        <property type="nucleotide sequence ID" value="XM_003039542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQ30"/>
    <dbReference type="GeneID" id="9667111"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55916"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55916"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002678_42_18_1"/>
    <dbReference type="InParanoid" id="C7ZQ30"/>
    <dbReference type="OMA" id="GLARHMH"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF22">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G11480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU33875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="103" mass="11830" checksum="26EC13738E0359F0" modified="2009-10-13" version="1" fragment="single">QSFNRKSDLQRHYRIHTNERPYACTIPSCGKSFIQRSALTVHVRTHTGEKPHQCQYIGCGKRFSDSSSLARHRRIHTGERPYKCGHNGCLKRSAIWPLLKPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZR45</accession>
    <name>C7ZR45_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_102310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699031">
        <property type="protein sequence ID" value="EEU33511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039224.1">
        <property type="nucleotide sequence ID" value="XM_003039178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZR45"/>
    <dbReference type="GeneID" id="9666746"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102310"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102310"/>
    <dbReference type="eggNOG" id="ENOG502R9T1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_696553_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZR45"/>
    <dbReference type="OMA" id="LNASWRM"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU33511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="396" mass="44375" checksum="363DF1A186CBA903" modified="2009-10-13" version="1">MAVTLDKLVLAIHCQATGNSGGGKGLAGARFVLVCRLRVWDWLVWVPLSRPVGSVSCCESYLGRWESHQRLLLRMSFVLVLAPFGYNTLWLPLFGSDLLTVPNVTTLLLHIPPETIAELTVGCPNELHQIVREQLGPRTTCLSFRLHQPPQLVVPKGPLAPRRQREHGDKLDSLKLLSQATSLDIYFDHGILQDATARTVCDLAASPRARSVAQYANLDSLYAGKGGVVLAAESPPSPPTAFPPAYNELCGTTPPPPPHQDHPSPARSSRKRRRKSPDPFDVESICPRAVKDMFSLYKKDLQEMLGEIKNDILDHVDRRLNEIHRLSDTYNREEIDELVQEVRNDGEDYTDSKINDRVLDIKAELKEYAEDQLRDTEERVLKRLKSASWALKTGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-04-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>H6D5C7</accession>
    <name>H6D5C7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">NADH-ubiquinone oxidoreductase chain 4L</fullName>
            <ecNumber evidence="4 13">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">nad4L</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="14"/>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="2" last="14">
            <title>Comparative analysis of Fusarium mitochondrial genomes reveals a highly variable region that encodes an exceptionally large open reading frame.</title>
            <authorList>
                <person name="Al-Reedy R.M."/>
                <person name="Malireddy R."/>
                <person name="Dillman C.B."/>
                <person name="Kennell J.C."/>
            </authorList>
            <dbReference type="PubMed" id="22178648"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2011.11.008"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
            <strain evidence="14">MpVI</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Mitochondrion inner membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the complex I subunit 4L family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="4 13"/>
    <dbReference type="EMBL" id="JN041209">
        <property type="protein sequence ID" value="AEJ72894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H6D5C7"/>
    <dbReference type="SMR" id="H6D5C7"/>
    <dbReference type="STRING" id="660122.H6D5C7"/>
    <dbReference type="InParanoid" id="H6D5C7"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030964">
        <property type="term" value="C:NADH dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3510:FF:000004">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase chain 4L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001133">
        <property type="entry name" value="NADH_UbQ_OxRdtase_chain4L/K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004320">
        <property type="entry name" value="PRK05715.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11434:SF16">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11434">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT ND4L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="13" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 13" id="KW-0813">Transport</keyword>
    <keyword evidence="13" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AEJ72894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="89" mass="9821" checksum="123FE34336BD38D6" modified="2012-04-18" version="1">MNLTLVLFLIGILGFVFNRKNIILMLISIEIMLLSITFLILVSSVNIDDIIGQTYAIYIIVVAGAESAIGLAILVAFYRLRGSIAIEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C7YGU8</accession>
    <name>C7YGU8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">DNA replication complex GINS protein PSF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_98779</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the GINS1/PSF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053517.1">
        <property type="nucleotide sequence ID" value="XM_003053471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YGU8"/>
    <dbReference type="FunCoup" id="C7YGU8">
        <property type="interactions" value="434"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YGU8"/>
    <dbReference type="GeneID" id="9676849"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_98779"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98779"/>
    <dbReference type="eggNOG" id="KOG3303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079191_0_0_1"/>
    <dbReference type="InParanoid" id="C7YGU8"/>
    <dbReference type="OMA" id="MFCEKAT"/>
    <dbReference type="OrthoDB" id="10252587at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11710">
        <property type="entry name" value="GINS_A_psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1030:FF:000003">
        <property type="entry name" value="DNA replication complex GINS protein PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005339">
        <property type="entry name" value="GINS_Psf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914:SF2">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914">
        <property type="entry name" value="PARTNER OF SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="9">
        <location>
            <begin position="46"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU47804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="187" mass="20749" checksum="A3D41445A6E8E20C" modified="2009-10-13" version="1">MYGDLGNKLVQHAKRTQNLTHLPPYQAEIVRAVAREVRDLDKDVAELLEPFQGSFDPSADQAVACTLLVNHLSMRRNKRCLLAYHRTRTDKLEKLVWNGADVVDLSGQQVRDGAGHSTSGGPGPSDAPTSSLSPQEEDYVRQYSDLLAAYKGQWTDIDLTGSLEPPRDLFIDVRVLKDAGEIQTEYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7YGZ5</accession>
    <name>C7YGZ5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin-related protein 2/3 complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_65610</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Cytoskeleton</location>
            <location evidence="7">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the WD repeat ARPC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053539.1">
        <property type="nucleotide sequence ID" value="XM_003053493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YGZ5"/>
    <dbReference type="FunCoup" id="C7YGZ5">
        <property type="interactions" value="809"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YGZ5"/>
    <dbReference type="GeneID" id="9664416"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_65610"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_65610"/>
    <dbReference type="eggNOG" id="KOG1523">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034396_1_0_1"/>
    <dbReference type="InParanoid" id="C7YGZ5"/>
    <dbReference type="OMA" id="YVWEPSP"/>
    <dbReference type="OrthoDB" id="406844at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000601">
        <property type="term" value="P:positive regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000220">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017383">
        <property type="entry name" value="ARPC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709:SF2">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038093">
        <property type="entry name" value="ARP2/3_su1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU47826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="363" mass="39697" checksum="7A6D48E44E58FCAF" modified="2009-10-13" version="1">MAAPEVHHLFHNPIADHSFSADHSVLAVARDTAVELYGKVGNAYKLKDELKGHDKTVTSVDIAPNSGRIVTCSQDRNALVWEPSPTGYKPTLVLLRISRAATFVRWSPSETKFAVGSGDRVIAVCYFEEENDWWVSKHLKKPIRSTITSVAWHPNSVLLAAGSTDAHARVFSAFIKGMDARPAPGVWGERLPFNTVCGEYLNNSAGWVHSVSFSPSGDSLAFAAHDSSITVVYPSGPEQPPRAVVTVTTQQLPFKSLIWTSEDEIIAAGYDCEAFRFQGGEGGWQLAGTIETKGRPSLGEHREESALNMFRQMDLKGKAKDDTQLKTVHQNTISTVRPFDTDGERVTKFSTSGVDGRVVVWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHP1</accession>
    <name>C7YHP1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_102382</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054386.1">
        <property type="nucleotide sequence ID" value="XM_003054340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YHP1"/>
    <dbReference type="STRING" id="660122.C7YHP1"/>
    <dbReference type="GeneID" id="9664617"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102382"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102382"/>
    <dbReference type="eggNOG" id="KOG0541">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072440_3_0_1"/>
    <dbReference type="InParanoid" id="C7YHP1"/>
    <dbReference type="OMA" id="SAWGKQH"/>
    <dbReference type="OrthoDB" id="1882547at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000159">
        <property type="entry name" value="Peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF39">
        <property type="entry name" value="PEROXISOMAL MEMBRANE ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="30"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="6">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU48673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="184" mass="19907" checksum="36BC9802A247F69F" modified="2009-10-13" version="1">MAFRASFRRVALARPATVARSFHSTPRAMVRVGQEIPDLDVLVEDSPGNKVNLAEEFKSGNGYIVGVPAAFSGTCSSKHVPSYMNHPKLKEAGQVFVVSVNDPFVMKAWSEQLDPAKQTGIRFLGDPTGEFTKALDLGFDAYAIFGGMRGKRYALKVEDGKVKEAHVEPDNTGSSVSMAEQVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHX7</accession>
    <name>C7YHX7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Early meiotic induction protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_75122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054424.1">
        <property type="nucleotide sequence ID" value="XM_003054378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YHX7"/>
    <dbReference type="STRING" id="660122.C7YHX7"/>
    <dbReference type="GeneID" id="9674655"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75122"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75122"/>
    <dbReference type="eggNOG" id="ENOG502S4MN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074897_1_0_1"/>
    <dbReference type="InParanoid" id="C7YHX7"/>
    <dbReference type="OMA" id="FGGQWVN"/>
    <dbReference type="OrthoDB" id="2017405at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021475">
        <property type="entry name" value="Pants/Emi1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052:SF1">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11326">
        <property type="entry name" value="PANTS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU48711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="23098" checksum="E908A89163ED0B68" modified="2009-10-13" version="1">MGWLWSSSNKDKPSTLSEEAPPTSTPSQQPPPSTSTSTTTDPEIQKFIDLFESEKNAKPEPASQKDQQSSSLPSWLTLKKSTRATTPTPSDIPPLGTLSEALLPTDMSCRQAFDQAWACNSMGGQWNAVYRYGEMRSCSEHWDDFWFCMRTKGYSPEMREKAIREHYRAKEFVKYGPGKPSSEDVWESREERVPEGSTFNQPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIJ0</accession>
    <name>C7YIJ0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyltransferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_75341</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054529.1">
        <property type="nucleotide sequence ID" value="XM_003054483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIJ0"/>
    <dbReference type="STRING" id="660122.C7YIJ0"/>
    <dbReference type="GeneID" id="9676450"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75341"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75341"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019940_4_1_1"/>
    <dbReference type="InParanoid" id="C7YIJ0"/>
    <dbReference type="OMA" id="HEKHIWY"/>
    <dbReference type="OrthoDB" id="3828420at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06434">
        <property type="entry name" value="GT2_HAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052427">
        <property type="entry name" value="Glycosyltrans_GT2/GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844:SF1">
        <property type="entry name" value="EXOSTOSIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844">
        <property type="entry name" value="SYNTHASE CPS1, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G02500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU48816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="531" mass="61682" checksum="A9F80636238502C8" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIM7</accession>
    <name>C7YIM7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">threonine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NECHADRAFT_31483</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053833.1">
        <property type="nucleotide sequence ID" value="XM_003053787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIM7"/>
    <dbReference type="FunCoup" id="C7YIM7">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YIM7"/>
    <dbReference type="GeneID" id="9676469"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_31483"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_31483"/>
    <dbReference type="eggNOG" id="KOG1637">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008554_2_1_1"/>
    <dbReference type="InParanoid" id="C7YIM7"/>
    <dbReference type="OMA" id="SCKGHPL"/>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070159">
        <property type="term" value="P:mitochondrial threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000039">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF50">
        <property type="entry name" value="THREONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="44"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU48120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="485" mass="55239" checksum="072ACD17459D4499" modified="2009-10-13" version="1">MIRSRTARAALTASVKRPWTCPTCLSRRRLYSQKPEKREPPDHRKLGLQQELFISSIYSPGSPIFLPNGARIFNRLVDFLRKQYVRYGFEEVITPTIYKKSLWAKSGHLENYADDMYAVRGNTEQPPAEHDGCCGSHPENLKPEDEEEGDYGLKPMNCPGHCLIFASKRHSYRDLPIRYADFSPLHRNEISGALSGLTRVRRFHQDDGHIFCRPCQVEEEIKKTLDFVKVVYTVLRFGASYRLALSTRPKDHYIGTEEEWAQAENALKRALDASGMEWGVKEGDGAFYGPKIDIVLTDSDGKEHQTATIQLDFQLPKRFELEYQAPAPEYEARGETTEDPALLAEYGPVRPVMIHRAVLGSVERLMALLIEKYDGKWPFWLNPRQAIILTVNTSTPVLDWAEHVRDVLVGHNKQNVFRPTGLAVDVDTTARPLGAKIKEARTNGYGQILVVGDEDVKNKQVALGRERISPEDLRERLKTMVDTFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7YK15</accession>
    <name>C7YK15_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_30860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054082.1">
        <property type="nucleotide sequence ID" value="XM_003054036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YK15"/>
    <dbReference type="STRING" id="660122.C7YK15"/>
    <dbReference type="GeneID" id="9676708"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_30860"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_30860"/>
    <dbReference type="eggNOG" id="KOG1703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009967_0_0_1"/>
    <dbReference type="InParanoid" id="C7YK15"/>
    <dbReference type="OMA" id="CGDPFTP"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000077">
        <property type="entry name" value="LIM domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205">
        <property type="entry name" value="FOUR AND A HALF LIM DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205:SF16">
        <property type="entry name" value="GH01042P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="582"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="678"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="741"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="137"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="187"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="358"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="445"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU48369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="804" mass="88023" checksum="25EB83B5DB708155" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7YK39</accession>
    <name>C7YK39_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_103059</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053390.1">
        <property type="nucleotide sequence ID" value="XM_003053344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YK39"/>
    <dbReference type="STRING" id="660122.C7YK39"/>
    <dbReference type="GeneID" id="9664023"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_103059"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_103059"/>
    <dbReference type="eggNOG" id="KOG0252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_46_14_1"/>
    <dbReference type="InParanoid" id="C7YK39"/>
    <dbReference type="OMA" id="CYRCTCH"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="518"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="555"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="590"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="47"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU47677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="675" mass="74817" checksum="35EC6C838F39195C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7YKC2</accession>
    <name>C7YKC2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_30596</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054142.1">
        <property type="nucleotide sequence ID" value="XM_003054096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YKC2"/>
    <dbReference type="STRING" id="660122.C7YKC2"/>
    <dbReference type="GeneID" id="9664148"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_30596"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_30596"/>
    <dbReference type="eggNOG" id="KOG2538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015257_1_0_1"/>
    <dbReference type="InParanoid" id="C7YKC2"/>
    <dbReference type="OMA" id="YCLMEHY"/>
    <dbReference type="OrthoDB" id="10265211at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20704">
        <property type="entry name" value="Orc3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020795">
        <property type="entry name" value="ORC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045667">
        <property type="entry name" value="ORC3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040855">
        <property type="entry name" value="ORC_WH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07034">
        <property type="entry name" value="ORC3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18137">
        <property type="entry name" value="WHD_ORC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 3 N-terminal" evidence="7">
        <location>
            <begin position="41"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 3 winged helix C-terminal" evidence="8">
        <location>
            <begin position="598"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU48429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="701" mass="78243" checksum="96264305D5069EC3" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7YKD0</accession>
    <name>C7YKD0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_103079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053426.1">
        <property type="nucleotide sequence ID" value="XM_003053380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YKD0"/>
    <dbReference type="FunCoup" id="C7YKD0">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YKD0"/>
    <dbReference type="GeneID" id="9676758"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_103079"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_103079"/>
    <dbReference type="eggNOG" id="ENOG502QQW9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028296_1_0_1"/>
    <dbReference type="InParanoid" id="C7YKD0"/>
    <dbReference type="OMA" id="ISRYCYW"/>
    <dbReference type="OrthoDB" id="164921at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019431">
        <property type="entry name" value="DUF2417"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10329">
        <property type="entry name" value="DUF2417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU47713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="58404" checksum="FE7070C62FE12F29" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7YL45</accession>
    <name>C7YL45_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_77401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003052859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YL45"/>
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    <dbReference type="KEGG" id="nhe:NECHADRAFT_77401"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77401"/>
    <dbReference type="eggNOG" id="ENOG502T4I6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1759294_0_0_1"/>
    <dbReference type="InParanoid" id="C7YL45"/>
    <dbReference type="OMA" id="PVIWIVY"/>
    <dbReference type="OrthoDB" id="4927953at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU47192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="148" mass="16504" checksum="C120219DBCA3EBEE" modified="2009-10-13" version="1">MLLFNPLHSRMVPGGSSVDLPEDSKKFNSHSPDPQTITKIVITAWVVGWFVFGIISILVINGNGRAGRWVPEWYLDSRGKMKHKLAVLGWWVFVVLFWPLIWIGYTVKKIVGVFASCVGKCKRRGDGLKKLNSNASADEKGKGYDTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLL7</accession>
    <name>C7YLL7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongation factor 1-alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ERF-3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">ERF2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic peptide chain release factor GTP-binding subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Polypeptide release factor 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Translation release factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">NECHADRAFT_58889</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="EEU46801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052514.1">
        <property type="nucleotide sequence ID" value="XM_003052468.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="C7YLL7">
        <property type="interactions" value="936"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YLL7"/>
    <dbReference type="GeneID" id="9663769"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_58889"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_58889"/>
    <dbReference type="eggNOG" id="KOG0459">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_3_8_1"/>
    <dbReference type="InParanoid" id="C7YLL7"/>
    <dbReference type="OMA" id="ARFDECT"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03704">
        <property type="entry name" value="eRF3_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04089">
        <property type="entry name" value="eRF3_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000017">
        <property type="entry name" value="Eukaryotic peptide chain release factor GTP-binding subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000503">
        <property type="entry name" value="Peptide chain release factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000061">
        <property type="entry name" value="Translation release factor eRF3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003285">
        <property type="entry name" value="Sup35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01343">
        <property type="entry name" value="YEASTERF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Tr-type G" evidence="16">
        <location>
            <begin position="268"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="100"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="104"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEU46801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="701" mass="76392" checksum="0EED50D92259E856" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLM6</accession>
    <name>C7YLM6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_91745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052518.1">
        <property type="nucleotide sequence ID" value="XM_003052472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YLM6"/>
    <dbReference type="FunCoup" id="C7YLM6">
        <property type="interactions" value="833"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YLM6"/>
    <dbReference type="GeneID" id="9663774"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_91745"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_91745"/>
    <dbReference type="eggNOG" id="KOG0028">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061288_18_1_1"/>
    <dbReference type="InParanoid" id="C7YLM6"/>
    <dbReference type="OMA" id="EFFMIMK"/>
    <dbReference type="OrthoDB" id="343296at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050145">
        <property type="entry name" value="Centrin_CML-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23050">
        <property type="entry name" value="CALCIUM BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="47"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="132"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="170"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU46805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="203" mass="23325" checksum="764043281CBDCDCC" modified="2009-10-13" version="1">MNSHTTPRPAFPVRSIGGGGSSHPPQSRQPVAPQVSSNEEYSTIPEEDREHIDEVFDLMDMKKKGWLNSYEFRHSLAALGFDMSKPDYFRELESYGTVPPDWQDPHSCPVNRLYVYLDQFRLCAAKLLANRDPRQEATKVFNMFDYDGDGIISFEDMRRLASDIKEERTMTDEEIQSMIEHLDHEGKGGVNLEEFIQMMEEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLN1</accession>
    <name>C7YLN1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Histone acetyltransferase</fullName>
            <ecNumber evidence="3 14">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">HAM2101</name>
        <name evidence="18" type="ORF">NECHADRAFT_91747</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 14"/>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053009.1">
        <property type="nucleotide sequence ID" value="XM_003052963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YLN1"/>
    <dbReference type="STRING" id="660122.C7YLN1"/>
    <dbReference type="GeneID" id="9671054"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_91747"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_91747"/>
    <dbReference type="eggNOG" id="KOG2747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005327_1_2_1"/>
    <dbReference type="InParanoid" id="C7YLN1"/>
    <dbReference type="OMA" id="DNAHRQC"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990467">
        <property type="term" value="C:NuA3a histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16866">
        <property type="entry name" value="PHD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="16">
        <location>
            <begin position="177"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="MYST-type HAT" evidence="17">
        <location>
            <begin position="514"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="239"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="809"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="400"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="819"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="835"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="931"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="947"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1017"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1066"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="12">
        <location>
            <position position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEU47296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1077" mass="120005" checksum="D3F1C3AC45A2F577" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLN8</accession>
    <name>C7YLN8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">General negative regulator of transcription subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_58915</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052523.1">
        <property type="nucleotide sequence ID" value="XM_003052477.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="C7YLN8">
        <property type="interactions" value="1225"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YLN8"/>
    <dbReference type="GeneID" id="9663781"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_58915"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_58915"/>
    <dbReference type="eggNOG" id="KOG1831">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000286_3_1_1"/>
    <dbReference type="InParanoid" id="C7YLN8"/>
    <dbReference type="OMA" id="IDEYHCY"/>
    <dbReference type="OrthoDB" id="1933107at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20710">
        <property type="entry name" value="NOT1_connector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000012">
        <property type="entry name" value="Ccr4-Not transcription complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.840">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1 TTP binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007196">
        <property type="entry name" value="CCR4-Not_Not1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032191">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024557">
        <property type="entry name" value="CNOT1_dom_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032194">
        <property type="entry name" value="CNOT1_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032193">
        <property type="entry name" value="CNOT1_TTP_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038535">
        <property type="entry name" value="CNOT1_TTP_bind_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16415">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16418">
        <property type="entry name" value="CNOT1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16417">
        <property type="entry name" value="CNOT1_TTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12842">
        <property type="entry name" value="DUF3819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04054">
        <property type="entry name" value="Not1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 HEAT repeat" evidence="13">
        <location>
            <begin position="516"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 TTP binding" evidence="12">
        <location>
            <begin position="707"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="11">
        <location>
            <begin position="920"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1" evidence="10">
        <location>
            <begin position="1201"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="9">
        <location>
            <begin position="1817"/>
            <end position="2182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="866"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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            <begin position="31"/>
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</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
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                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
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                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
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                <person name="Salamov A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rodriguez-Carres M."/>
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                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
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                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
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                <person name="Kroken S."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
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    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="11">
        <location>
            <begin position="55"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU47561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="314" mass="34867" checksum="9E245DC932A9108E" modified="2009-10-13" version="1">MVTTASPPSSASPYLQQSWHQFIPSSQTWSRVETSGPPRQASELGRNLDPKLRIVTWNVDAGAHFTESRLEAIVSHILCQKPVADIIFFQEVSRPALLHLLKDTRIRDSWFSTEADTTNWGGHIFATMMLVSKARFGPSNKSMSVSALGPVWRVKFPSRFGRDALCSDIFVSSPTDNSSQISRLRLINVHLDSLALERSRRPEQLSIAAEMLRETGKGLIAGDFNPVLPEDNTLVAYNGLVDAWTKVHDSEPGFTWGVDGKQAFPPGRLDKIAILGLQPHEIEVMHPGVIEKEEFGVGQVPWSDHSGLRCTFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNR7</accession>
    <name>C7YNR7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_92941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052336.1">
        <property type="nucleotide sequence ID" value="XM_003052290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNR7"/>
    <dbReference type="GeneID" id="9670858"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_92941"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_92941"/>
    <dbReference type="eggNOG" id="ENOG502SNG2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024747_1_0_1"/>
    <dbReference type="InParanoid" id="C7YNR7"/>
    <dbReference type="OMA" id="PYRCKVE"/>
    <dbReference type="OrthoDB" id="5062908at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059009">
        <property type="entry name" value="Znf_C2H2_17_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059095">
        <property type="entry name" value="Znf_C2H2_17_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26177">
        <property type="entry name" value="zf_C2H2_17_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26176">
        <property type="entry name" value="zf_C2H2_17_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="324"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="360"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU46623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="515" mass="56165" checksum="3B3C36DA06349DED" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7YP35</accession>
    <name>C7YP35_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RecF/RecN/SMC N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NECHADRAFT_92410</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051938.1">
        <property type="nucleotide sequence ID" value="XM_003051892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YP35"/>
    <dbReference type="FunCoup" id="C7YP35">
        <property type="interactions" value="831"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YP35"/>
    <dbReference type="GeneID" id="9672844"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_92410"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_92410"/>
    <dbReference type="eggNOG" id="KOG0250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009063_0_0_1"/>
    <dbReference type="InParanoid" id="C7YP35"/>
    <dbReference type="OMA" id="FMCHRSL"/>
    <dbReference type="OrthoDB" id="10072614at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="14">
        <location>
            <begin position="121"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="376"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="773"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU46225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1163" mass="133357" checksum="8597DFB34E53C78E" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7YP72</accession>
    <name>C7YP72_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_5957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051960.1">
        <property type="nucleotide sequence ID" value="XM_003051914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YP72"/>
    <dbReference type="GeneID" id="9670913"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_5957"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_5957"/>
    <dbReference type="eggNOG" id="ENOG502SQ4J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057711_0_0_1"/>
    <dbReference type="InParanoid" id="C7YP72"/>
    <dbReference type="OMA" id="TTWLREY"/>
    <dbReference type="OrthoDB" id="3009728at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU46247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="262" mass="28815" checksum="057D2A7818981D85" modified="2009-10-13" version="1" fragment="single">MIECIFDHTPEFIKSKMAAAAIVLGLSPTIIATLGVRPQETAVLSVVGRRHLLAFALAVGSPALNAYRSSEYNSIIDSLRERSRQRPNAMRRLDPFVTAISYCLAGASIANIGELTYQLGARTIFIVLPDSAYLALLWAFIGVFIHFMAAIALRCRVSSEVKSVDEEMTQGSWPVSVAKGQIDLMARRSRIIFTVHPESLSFFSMSFITTISTACHIIFGTMVFSSILFVSINDSLSIVARLMASAIVCRIIVTYELLVLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>C7YP83</accession>
    <name>C7YP83_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_68037</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in the regulation of membrane traffic through the trans-Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Binds to ARF1 and ARF2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051965.1">
        <property type="nucleotide sequence ID" value="XM_003051919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YP83"/>
    <dbReference type="FunCoup" id="C7YP83">
        <property type="interactions" value="785"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YP83"/>
    <dbReference type="GeneID" id="9668591"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_68037"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_68037"/>
    <dbReference type="eggNOG" id="KOG1087">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017092_0_0_1"/>
    <dbReference type="InParanoid" id="C7YP83"/>
    <dbReference type="OMA" id="PDNYEPN"/>
    <dbReference type="OrthoDB" id="2018246at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14235">
        <property type="entry name" value="GAT_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16998">
        <property type="entry name" value="VHS_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.160:FF:000003">
        <property type="entry name" value="VHS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000008">
        <property type="entry name" value="VHS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000024">
        <property type="entry name" value="VHS domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052653">
        <property type="entry name" value="ARF-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041198">
        <property type="entry name" value="GGA_N-GAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18308">
        <property type="entry name" value="GGA_N-GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="10">
        <location>
            <begin position="34"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="12">
        <location>
            <begin position="197"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="GAE" evidence="11">
        <location>
            <begin position="524"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="423"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="370"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU46252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="646" mass="69401" checksum="1C38F9E49E24743D" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQ11</accession>
    <name>C7YQ11_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_78943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052100.1">
        <property type="nucleotide sequence ID" value="XM_003052054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQ11"/>
    <dbReference type="GeneID" id="9668886"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78943"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78943"/>
    <dbReference type="eggNOG" id="ENOG502T6DT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004184_7_2_1"/>
    <dbReference type="InParanoid" id="C7YQ11"/>
    <dbReference type="OrthoDB" id="5416609at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="142"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU46387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="813" mass="92693" checksum="067A4ED208C3A575" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQA3</accession>
    <name>C7YQA3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidoligase enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_79034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051700.1">
        <property type="nucleotide sequence ID" value="XM_003051654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQA3"/>
    <dbReference type="STRING" id="660122.C7YQA3"/>
    <dbReference type="GeneID" id="9668929"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79034"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79034"/>
    <dbReference type="eggNOG" id="ENOG502SUNA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_341643_0_0_1"/>
    <dbReference type="InParanoid" id="C7YQA3"/>
    <dbReference type="OMA" id="RESNIMT"/>
    <dbReference type="OrthoDB" id="412402at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022025">
        <property type="entry name" value="Amidoligase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847:SF1">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12224">
        <property type="entry name" value="Amidoligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU45987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="830" mass="94077" checksum="14F1468805BBA6CA" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQN9</accession>
    <name>C7YQN9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="19">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">NECHADRAFT_68501</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">NADH-dependent reductase for DPH3 and cytochrome b5. Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. By reducing DPH3, also involved in the formation of the tRNA wobble base modification mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), mediated by the elongator complex. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>2 Fe(3+)-[Dph3] + NADH = 2 Fe(2+)-[Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71231"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:71232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer. Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="19"/>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051770.1">
        <property type="nucleotide sequence ID" value="XM_003051724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQN9"/>
    <dbReference type="SMR" id="C7YQN9"/>
    <dbReference type="FunCoup" id="C7YQN9">
        <property type="interactions" value="285"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YQN9"/>
    <dbReference type="GeneID" id="9673593"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_68501"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_68501"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_9_0_1"/>
    <dbReference type="InParanoid" id="C7YQN9"/>
    <dbReference type="OMA" id="DRPKPEW"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000019">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF184">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 18 19" id="KW-0274">FAD</keyword>
    <keyword evidence="5 18 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="11 19" id="KW-0520">NAD</keyword>
    <keyword evidence="10 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="21">
        <location>
            <begin position="63"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EEU46057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="312" mass="34160" checksum="3F09C085821F446E" modified="2009-10-13" version="1">MSSGDNSLFARHYIDYVYMPGVLLIVGTLIVKKEWTPFAALIAVAFGAYNFLAFQVKKVLKPDVFQEFELEEKTIISHNVAIYRFKLPSPKHILGLPIGQHISIGAPCVQPDGSTKEIVRSYTPVSGDHQPGYFDLLIKSYPQGNISKHMASLVVGQTIRVRGPKGAFVYTPNMVRHFGMVAGGTGITPMLQVIRAIIRGRAAGDKTEVDLIFANVSPQDILLKEDLDSLAAKDAGIRIHYVLDKPPEGWTGGVGYVTADMITKWLPKPADDVKILLCGPPPMISGLKKAAESLGFKKARPVSKLEDQIFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7YS65</accession>
    <name>C7YS65_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_40576</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050907.1">
        <property type="nucleotide sequence ID" value="XM_003050861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YS65"/>
    <dbReference type="FunCoup" id="C7YS65">
        <property type="interactions" value="152"/>
    </dbReference>
    <dbReference type="GeneID" id="9668143"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_40576"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_40576"/>
    <dbReference type="eggNOG" id="KOG4372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027968_1_1_1"/>
    <dbReference type="InParanoid" id="C7YS65"/>
    <dbReference type="OMA" id="FCTPHVG"/>
    <dbReference type="OrthoDB" id="273452at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000223">
        <property type="entry name" value="Lipase/serine esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF65">
        <property type="entry name" value="ESTERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="15"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU45194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="445" mass="50638" checksum="456FC4190A7C3D75" modified="2009-10-13" version="1">MTTSVAMDDLTGGSPKADHLCVLVHGLWGNPSHMRSIAKTLREQYSYDELYLLLAKQNSGNFTYDGIERGGERVCAEIERELRKVEDEGGKITKLSIVGYSLGGLVSRYAVGLLYAKGILDTLECMNFTTFASPHLGVRSPLKGWHNHVWNVLGARTLSMSGRQLFTIDKFRDTDRPLLSVLADPNSIFMSGLRKFKRRTLYANTINDRSAVYYTTCIAKTDPYTNLEKVKLNYLKGYEGVLLDPNNPVTPFPKVQTPASLSTVYASSVKWFKRIPFMLAIGVLVPVGVVAFLINSVIQTIRSSSRIKLHEMGQGGLNVEDYRMSMWIKEIREEVENTYEAINSSQNQEYLGTEDEEEDEHLDLEQRTVIRRERRMSTVSQPTLALAPYQFEMIRNLDDLGWRKYPVHIQNHRHTHAAIIVRFEKKGFEEGWVVLKHYAGSEFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSC4</accession>
    <name>C7YSC4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_69661</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051324.1">
        <property type="nucleotide sequence ID" value="XM_003051278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSC4"/>
    <dbReference type="STRING" id="660122.C7YSC4"/>
    <dbReference type="GeneID" id="9666181"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_69661"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_69661"/>
    <dbReference type="eggNOG" id="KOG2689">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047594_0_0_1"/>
    <dbReference type="InParanoid" id="C7YSC4"/>
    <dbReference type="OMA" id="AQHFPRK"/>
    <dbReference type="OrthoDB" id="10254930at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032435">
        <property type="term" value="P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903094">
        <property type="term" value="P:negative regulation of protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="6">
        <location>
            <begin position="239"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="89"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="140"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU45611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="35227" checksum="B43F6279026CF8D4" modified="2009-10-13" version="1">MPSDLDTLLDMGFGKERAELAVKKSGGLQGALQWLEDNQDKPLEEIKAAAADDKEDDEDDDTEAKIAELETGKAKSLVCNECGKRFRSHDLASYHATKTEHTDFSESTEELAPLTEDEKKAKLDELRERLQAKKAAQAMQDKEEQKRNEKIRQKSTRESQEAKEELARKQQIKEAEKKRQEKLEDMEAKKRIKAKIEADKAERRRKAEEAKAAREGRAPQAEAVATPAGGAAAAAAPKPKANHNEARLRLQTGGGNITKTLPAETTLFELAQQIESETGNVVTSFTTTFPRQTFQGDVDMSKTLKEAGLVPSSVLIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSG9</accession>
    <name>C7YSG9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_41758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050958.1">
        <property type="nucleotide sequence ID" value="XM_003050912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSG9"/>
    <dbReference type="FunCoup" id="C7YSG9">
        <property type="interactions" value="262"/>
    </dbReference>
    <dbReference type="GeneID" id="9668196"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_41758"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_41758"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="InParanoid" id="C7YSG9"/>
    <dbReference type="OMA" id="KMAGPIS"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF154">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_2G04560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU45245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="33362" checksum="895756D6A8CC246B" modified="2009-10-13" version="1">MSPDKTYPFNPLTDIPSLSGKVILITGANTGLGKATAIELSKHSPAHIYLTSRNSTKGNAALNEVKSVASDGTKVSLLELDLSSFQSIKAAARDFLKQQDRLDVLLLNAGVMGAPPVLTKDGYEAHMGTNHLGHALLFKLLQPTLQKTAATGADVRVIHLSSAGFRHVGPTGIEFETLKSATSETSLPLRYAQSKLACLLYAREAAKRIPNIKNIAINPGEVDTELFTREPGDDHMKMLQTEIAPKVVGPISEGVKNHLWATTSLDIENGEFYEPVGKTGGLEGHGLDDEMARKLWEWTEEQLKDQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7YT03</accession>
    <name>C7YT03_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_41061</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051040.1">
        <property type="nucleotide sequence ID" value="XM_003050994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YT03"/>
    <dbReference type="GeneID" id="9668450"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_41061"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_41061"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_3_1"/>
    <dbReference type="InParanoid" id="C7YT03"/>
    <dbReference type="OMA" id="FLYEETM"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF50">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
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                <person name="Rodriguez-Carres M."/>
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</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
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                <person name="Rodriguez-Carres M."/>
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                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
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                <person name="Zhou S."/>
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                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
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                <person name="Molnar I."/>
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                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050496.1">
        <property type="nucleotide sequence ID" value="XM_003050450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YUC9"/>
    <dbReference type="FunCoup" id="C7YUC9">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YUC9"/>
    <dbReference type="GeneID" id="9665544"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_71937"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_71937"/>
    <dbReference type="eggNOG" id="ENOG502QSA3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029376_1_0_1"/>
    <dbReference type="InParanoid" id="C7YUC9"/>
    <dbReference type="OMA" id="KTILQVY"/>
    <dbReference type="OrthoDB" id="77989at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="127"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU44783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="489" mass="53480" checksum="BB764D53CD95E497" modified="2009-10-13" version="1">MSTHREGFNPLRPYYIPPTIGEPSETLAKSSPSPNPFPDGRHVTAAGGRYASKARDILNDLEYKDYLGDNSPSMVQNVKDLIDELLWKYTSVLMAQPFEVAKTLLQVRNQDENAALVASTVEPEPLKKRTSTYGSSMYDFHESDSEGDEPAYFTSSVPATPTPSGPKSSNGRRSPSPLPKPKIPEHYLTLRRPDSILEVIGQLWGKEGAWGVWKGSNAAFLYTVLQSLLENWSRSFLSAIFNVPDIGVKEDIDRLIDIASPYPWASLFVAATAAVATGLALSPLDLVRTRLIVTPSSRGQRRTLATLKALPSYLCSSILVIPTVLNSLVHPLITLSTPLVLRTRFMIDSQASPMTFSVAKFFASSAAILLKLPVETVLRRGQVSVLSTSEYVKALGGQEQALTTIVPPGRYEGPFGTMYHIATEEGTREVPTIRPSVTKKGKGKNKSVATTTYKGQGLEGLWRGWKVNWWGLVGLWTASVVGHGGEGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7YUH0</accession>
    <name>C7YUH0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_63695</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050514.1">
        <property type="nucleotide sequence ID" value="XM_003050468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YUH0"/>
    <dbReference type="STRING" id="660122.C7YUH0"/>
    <dbReference type="GeneID" id="9674910"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_63695"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_63695"/>
    <dbReference type="eggNOG" id="ENOG502S5J2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063111_1_0_1"/>
    <dbReference type="InParanoid" id="C7YUH0"/>
    <dbReference type="OMA" id="WYFALCW"/>
    <dbReference type="OrthoDB" id="5284712at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF3">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="14"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="186"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU44801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="276" mass="30390" checksum="05F86BF03E972F92" modified="2009-10-13" version="1">MAINFDPDIVPNLKLGLHSFQVIFSFVAWCLQIGVFNAKDAKVTGKNGWTFAVCFLSVPAWIFLIMTPRWERTRRFAQPHAMLAVDALFTVMWLSAFATQASYNAEGSCGKACGISKGVVGLGVLTTLLFAATTFVSAFTLNYYQNNNVLPGYDNRQIRGGDNIDPDKAAFSMAPHDDEAYERVNMEDNEPTGNPYGGYNGSYNSTTRYGDNNTNPYNAEDEDPARYGSTPGRTNTLFDNDTEYHSSGAQYGSNPTSGGYDDHPAHFPAGNYDRTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7YV85</accession>
    <name>C7YV85_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7735 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_105400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050249.1">
        <property type="nucleotide sequence ID" value="XM_003050203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YV85"/>
    <dbReference type="STRING" id="660122.C7YV85"/>
    <dbReference type="GeneID" id="9675034"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_105400"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_105400"/>
    <dbReference type="eggNOG" id="ENOG502T46U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117760_0_0_1"/>
    <dbReference type="InParanoid" id="C7YV85"/>
    <dbReference type="OMA" id="MSAVKEC"/>
    <dbReference type="OrthoDB" id="3561078at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056637">
        <property type="entry name" value="DUF7735"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24870">
        <property type="entry name" value="DUF7735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988568" description="DUF7735 domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7735" evidence="3">
        <location>
            <begin position="43"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU44536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="214" mass="21765" checksum="3CE3E68EDE31B4F2" modified="2009-10-13" version="1">MQSKIVLVSLLASAVSAQGNFMAHPQMKRDLLAPRATDSVAGLDKECQSAIMEVYKTLPTPAPEIVKDLTEHPQTDPCSFSTPASLSKEYASYSSEVLGWYSKNEAEIKSALEECPALSKYANAVPICSDAAAAGGDNTKATEATKTAEETEAETAATESGASKPSGSASAESASDAAATPTTSSPAQATNGAAREGGMIYAAAAVAGIVVAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVL4</accession>
    <name>C7YVL4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_29697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049730.1">
        <property type="nucleotide sequence ID" value="XM_003049684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVL4"/>
    <dbReference type="GeneID" id="9677465"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_29697"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_29697"/>
    <dbReference type="eggNOG" id="KOG1611">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_2_1"/>
    <dbReference type="InParanoid" id="C7YVL4"/>
    <dbReference type="OMA" id="NTVGNVH"/>
    <dbReference type="OrthoDB" id="7289984at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF3">
        <property type="entry name" value="CHAIN DEHYDROGENASE (ATSC), PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU44017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="271" mass="29390" checksum="BCF5B584998AA468" modified="2009-10-13" version="1">MASYLVTGASRGLGFEFLRQLSDKSDNIVIGLVRNKQATVEKIERELSARKNVHIIQADINDYAALKASVDETSKITGGKLDYIVANAGLVSPWSAYDPLSVLGEQPEKLEEDLIDSFKVNVVGNIHLFNLYVPLLLKGQAKKAITLSTGMADPDFVTQFSISVSAPYSISKAAVNLAVAKFDAQYRKEGLLFMAVSPGLVDTGHYDEATEEQTRKAGEMLQQFQSYAPSFTGPITPEESVTAVLSVLHKASIEAGNGGSFVSHFGNKQWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7YW83</accession>
    <name>C7YW83_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_30328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049844.1">
        <property type="nucleotide sequence ID" value="XM_003049798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YW83"/>
    <dbReference type="GeneID" id="9677419"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_30328"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_30328"/>
    <dbReference type="eggNOG" id="ENOG502REX9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1008625_0_0_1"/>
    <dbReference type="InParanoid" id="C7YW83"/>
    <dbReference type="OMA" id="WARQNQP"/>
    <dbReference type="OrthoDB" id="5417135at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42088">
        <property type="entry name" value="YALI0F10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42088:SF1">
        <property type="entry name" value="YALI0F10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU44131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="276" mass="29229" checksum="9AA91F74DA40DFC3" modified="2009-10-13" version="1">MPPMQRGNGGPMPRGNGQYYDDYNQGNLGEAAAYFDPETNAFVMPYAEPVTRRAMTPPPSGRFRGGPGPRGPRGPHGPNGSIGGMSAQSGPRGRSRAGSALGPRPDSSASARFRQPPKKRLPPPAPLPTLPTPSKLTDDNFAIINAADFAPPDRIRDNVAGRSQSPFGERRPYSPTVPAAVPLVGAFDELTALPSPHLLRKSSTFTGLDFAPPKKFKDADTMSDAGSIRSNKSGMSQAQLGAIRAGAGRVSRLPGDTVFTQTSMQDALKPSWTLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWB3</accession>
    <name>C7YWB3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_29715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049862.1">
        <property type="nucleotide sequence ID" value="XM_003049816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWB3"/>
    <dbReference type="GeneID" id="9677437"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_29715"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_29715"/>
    <dbReference type="eggNOG" id="KOG4391">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043841_1_0_1"/>
    <dbReference type="InParanoid" id="C7YWB3"/>
    <dbReference type="OMA" id="CFWIVVM"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF64">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU44149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="304" mass="33949" checksum="E8EBBC172D3600A2" modified="2009-10-13" version="1">MVLFQNAIIYNPFLPPNARSMRIDEFSRECGGVQWREERIRSLDGTEIALCVSDMPASATGAKKPVYILYFQGNGSSIPPRLPHLSLILRRARDNDPSVTYTMVCLSYRGYWTSHDRPSEPGINLDSQAALQWISQLHNSRAEGTDQKPAVVLWGQSIGCGFATNLAAKGKCPPNIKLDALVLETPFTCTRAMLQALYPQKWLPYQYLWPFLRNHLDSWTNLGMIAKRFKESPPGVYIVEAGKDELVPGDHGEKLQRRCEHVGLPVERHRVRGALHNEAMVRASGKQALADSISTAAARAQHGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWP6</accession>
    <name>C7YWP6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_29776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049931.1">
        <property type="nucleotide sequence ID" value="XM_003049885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWP6"/>
    <dbReference type="STRING" id="660122.C7YWP6"/>
    <dbReference type="GeneID" id="9677283"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_29776"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_29776"/>
    <dbReference type="eggNOG" id="ENOG502RYVR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084257_0_0_1"/>
    <dbReference type="InParanoid" id="C7YWP6"/>
    <dbReference type="OMA" id="WPTFVPK"/>
    <dbReference type="OrthoDB" id="17725at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3620.10">
        <property type="entry name" value="YdcF like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051599">
        <property type="entry name" value="Cell_Envelope_Assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30336:SF20">
        <property type="entry name" value="DUF218 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30336">
        <property type="entry name" value="INNER MEMBRANE PROTEIN, PROBABLE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU44218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="313" mass="33659" checksum="59169FAC98D31F31" modified="2009-10-13" version="1">MPSFEEAVLAAEAANTISAFVAQEQIRTLSDLKHALFQPSATKHNQNATGTSHSASVIVLCASAVLSTAETVMSAVAELTKTTVLVLCGGIGHSTQLMHDAVLRHPQYNTLAEQVRGQPEGRILQAIGEKFFDLQISSNGSGSGDTQRQGLTVLVEDASTNCALNAQKTRELLDAHGFRSPRSIVVAQDPTMCRRTVAAFEQVYADVVEGPPIFSSWPTLVPKVIAKEASVGDTNSLLPYLDFADLGMGDGWKAGLWSMDRFMSLLVGEIPRMRDDENGYGPNGKGSIVHVDIPQDVEDAWKTLCELLGYSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXN2</accession>
    <name>C7YXN2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transglycosylase SLT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_106250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049331.1">
        <property type="nucleotide sequence ID" value="XM_003049285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXN2"/>
    <dbReference type="GeneID" id="9666387"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_106250"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_106250"/>
    <dbReference type="eggNOG" id="ENOG502RZDF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051871_2_0_1"/>
    <dbReference type="InParanoid" id="C7YXN2"/>
    <dbReference type="OMA" id="NGWFTAG"/>
    <dbReference type="OrthoDB" id="2537480at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002986632" description="Transglycosylase SLT domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Transglycosylase SLT" evidence="2">
        <location>
            <begin position="91"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU43618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="247" mass="26372" checksum="38EC28CBA2B869D1" modified="2009-10-13" version="1">MPSLTHYLIILSAVIVGSVVADVNPNAQGACDDTHGGQDACGPNGSEAWLNTGLNGEGWNPPFLDINGLKHISLEDYYNGVGRSCRQYDQYFKSSGEKYNIDPAILAFLAMQESSCNADAGGPTPGLMQCEPRNCQNGKSSYQYPIQDNVDCGAHVLRAALDNAGGNAVRAIGSYNGWFIKGFGLNGGKGITVDYPCSAEGRRNGAPQNLDYLHETLNGWFQGLDVYGSDAGKFATAVKVQGFWDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYB4</accession>
    <name>C7YYB4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Nucleoporin Nup157/170</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NECHADRAFT_70944</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the non-repetitive/WGA-negative nucleoporin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048872.1">
        <property type="nucleotide sequence ID" value="XM_003048826.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="C7YYB4">
        <property type="interactions" value="1213"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YYB4"/>
    <dbReference type="GeneID" id="9665794"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_70944"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_70944"/>
    <dbReference type="eggNOG" id="KOG1900">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000429_0_1_1"/>
    <dbReference type="InParanoid" id="C7YYB4"/>
    <dbReference type="OMA" id="SWAPFQK"/>
    <dbReference type="OrthoDB" id="338970at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051292">
        <property type="term" value="P:nuclear pore complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.440:FF:000001">
        <property type="entry name" value="Nuclear pore complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.450:FF:000002">
        <property type="entry name" value="Putative non-repetitive nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1880">
        <property type="entry name" value="Nucleoporin, helical C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.440">
        <property type="entry name" value="Nucleoporin, helical domain, central subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.450">
        <property type="entry name" value="Nucleoporin, helical domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004870">
        <property type="entry name" value="Nucleoporin_Nup155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042533">
        <property type="entry name" value="Nucleoporin_Nup155_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042537">
        <property type="entry name" value="Nucleoporin_Nup155_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042538">
        <property type="entry name" value="Nucleoporin_Nup155_C_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="14">
        <location>
            <begin position="139"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="13">
        <location>
            <begin position="680"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="40"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU43159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1403" mass="154966" checksum="AA66481452782477" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYE2</accession>
    <name>C7YYE2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ergothioneine biosynthesis protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_70968</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048884.1">
        <property type="nucleotide sequence ID" value="XM_003048838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYE2"/>
    <dbReference type="STRING" id="660122.C7YYE2"/>
    <dbReference type="GeneID" id="9665477"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_70968"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_70968"/>
    <dbReference type="eggNOG" id="ENOG502QS9T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006921_0_1_1"/>
    <dbReference type="InParanoid" id="C7YYE2"/>
    <dbReference type="OMA" id="FKHWHPT"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="entry name" value="paralog of FGE (formylglycine-generating enzyme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017805">
        <property type="entry name" value="SAM_MeTrfase_EasF-type_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03439">
        <property type="entry name" value="methyl_EasF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF1">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="9">
        <location>
            <begin position="54"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="DinB-like" evidence="10">
        <location>
            <begin position="380"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="8">
        <location>
            <begin position="573"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="721"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU43171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="854" mass="96425" checksum="2E7FBD7DB372CCA4" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZ06</accession>
    <name>C7YZ06_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_95606</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the GSE complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048808.1">
        <property type="nucleotide sequence ID" value="XM_003048762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZ06"/>
    <dbReference type="FunCoup" id="C7YZ06">
        <property type="interactions" value="586"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YZ06"/>
    <dbReference type="GeneID" id="9665655"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95606"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95606"/>
    <dbReference type="eggNOG" id="KOG3887">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047421_2_0_1"/>
    <dbReference type="InParanoid" id="C7YZ06"/>
    <dbReference type="OMA" id="NCRTFQE"/>
    <dbReference type="OrthoDB" id="26136at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11385">
        <property type="entry name" value="RagC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.190:FF:000005">
        <property type="entry name" value="Gtr1 g domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000643">
        <property type="entry name" value="Small monomeric GTPase (Gtr2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039400">
        <property type="entry name" value="RagC/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF2">
        <property type="entry name" value="GH16429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU43095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="392" mass="44098" checksum="89C91B34BA3390D9" modified="2009-10-13" version="1">MSLSPPIQNLTLSDEADDTGSSPAQLNLQRLYEQSRRGAPASSKDAQKPSTPGPNAGPAAKGKPRLLLMGQRRSGKSSISSVVFHKLPPNETLFLESTARIQKDSMASFMDFQVWDFPGQIDVFENPGFDIEAIFSEIGALIWVIDAQDDYLEAVMRLNTTILFLQRTYPNINIEVFIHKVDGLSDDYKLDIQRDITIRIQDELSDHGFENAPVTFHLTSIYNHSIFEAFSKVIQKLIPRLGTLESMLTNLCRTCRFEKAYLFDVLSKIYIATDSATADMASYEICSDYIDVIIDITEVYGTWQRSDDGRRRLEGEPWSAPIESQVGCPTAESCLVLHDGNKPIMLREVDRYLALVAIMKEDSYDSMPLVNMNVEAVVEGLTEFFDITKPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZW7</accession>
    <name>C7YZW7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7357 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_95828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048395.1">
        <property type="nucleotide sequence ID" value="XM_003048349.1"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YZW7"/>
    <dbReference type="GeneID" id="9667472"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95828"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95828"/>
    <dbReference type="eggNOG" id="ENOG502SF1H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002397_0_0_1"/>
    <dbReference type="InParanoid" id="C7YZW7"/>
    <dbReference type="OrthoDB" id="5368821at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055781">
        <property type="entry name" value="DUF7357"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24054">
        <property type="entry name" value="DUF7357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7357" evidence="2">
        <location>
            <begin position="6"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="745"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="917"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1393"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="464"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="612"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="763"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="936"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="965"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1056"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1094"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1115"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1221"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1239"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1263"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1298"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1398"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1438"/>
            <end position="1447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU42682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1447" mass="159777" checksum="CB8FB070803DE6BA" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0J0</accession>
    <name>C7Z0J0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase family 32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_123337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047927.1">
        <property type="nucleotide sequence ID" value="XM_003047881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0J0"/>
    <dbReference type="GeneID" id="9671912"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_123337"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_123337"/>
    <dbReference type="eggNOG" id="ENOG502R7TT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022381_0_1_1"/>
    <dbReference type="InParanoid" id="C7Z0J0"/>
    <dbReference type="OMA" id="WRYERIT"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF8">
        <property type="entry name" value="TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU42214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="35719" checksum="A5F7465D4687F21C" modified="2009-10-13" version="1">MSPLLTKRLFLYALLAGVATILMLVGHYAYNNSLHSNTSSRSILTSQSEQKEQPFPNKIWQSWKDDSEDPTERTVGFPHQWRAVNPDWRYERVIDANSDTYVRDNFDEPISEVFTRLEDPILKADFLRYLILLREGGVWADIDVLPLQPVSKWVPEEYQGKVNLVIGIENDHHKKPIWPGSPYSVQLCQYTVLAKPNHPALRNIVKQVTQDLDELLTSKNPGESVTFEEVMSTTGPFAFTKAMMDYFNEMTGEEHTGNELDRLKEPRLIGDVLVLPKDSFGWLSHENTHEEGDPSILVQHLFMGSWRGSHPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z177</accession>
    <name>C7Z177_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNA polymerase II assembly factor Rtp1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_39804</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Tango6 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048237.1">
        <property type="nucleotide sequence ID" value="XM_003048191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z177"/>
    <dbReference type="STRING" id="660122.C7Z177"/>
    <dbReference type="GeneID" id="9671841"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_39804"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_39804"/>
    <dbReference type="eggNOG" id="ENOG502SDA6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006300_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z177"/>
    <dbReference type="OMA" id="KRAYGAP"/>
    <dbReference type="OrthoDB" id="39591at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019451">
        <property type="entry name" value="Rtp1_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019414">
        <property type="entry name" value="Rtp1_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039600">
        <property type="entry name" value="TANGO6/Rtp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959:SF1">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10363">
        <property type="entry name" value="RTP1_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10304">
        <property type="entry name" value="RTP1_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="4">
        <location>
            <begin position="483"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="3">
        <location>
            <begin position="730"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="588"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="609"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU42524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="809" mass="88959" checksum="AB2BA0EFC99AC44E" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1B5</accession>
    <name>C7Z1B5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Diterpenoid pyrone biosynthesis cluster protein C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_39817</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048254.1">
        <property type="nucleotide sequence ID" value="XM_003048208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1B5"/>
    <dbReference type="FunCoup" id="C7Z1B5">
        <property type="interactions" value="408"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z1B5"/>
    <dbReference type="GeneID" id="9667220"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_39817"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_39817"/>
    <dbReference type="eggNOG" id="KOG1381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034879_1_1_1"/>
    <dbReference type="InParanoid" id="C7Z1B5"/>
    <dbReference type="OMA" id="WCMIYDT"/>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="UniPathway" id="UPA00213"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000008">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988851" description="Diterpenoid pyrone biosynthesis cluster protein C" evidence="11">
        <location>
            <begin position="30"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU42541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="277" mass="29493" checksum="864845F9B0809CB9" modified="2009-10-13" version="1">MVMPMATPGSVIGTSLLFFSGALIMRGAGCTINDLWDRNLDPHVARTRLRPIARGAVTPFKGLVYTGVQLLAGLGILLQFPLPCLFYGVPSLLLVASYPLAKRVTYYPQAVLGLTFSWGAIMGFPALGIDLLSNTPALTAAACLYASNIAWTVLYDMIYAHMDIKDDVKAGIKSIALKHDAETKQVLTGLAATQISLLAAAGFAAGAGPAFFIGSCGGAIVTLGVMIKRVNLKSVKDCWWWFINGCWITGGVISLGLAADYAVRYVQGPKDETKTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1T9</accession>
    <name>C7Z1T9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_85913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU42059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047772.1">
        <property type="nucleotide sequence ID" value="XM_003047726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1T9"/>
    <dbReference type="GeneID" id="9671557"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85913"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85913"/>
    <dbReference type="eggNOG" id="ENOG502RN1V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_783236_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z1T9"/>
    <dbReference type="OrthoDB" id="5080136at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU42059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="354" mass="38302" checksum="5DE2DA25586B4EB4" modified="2009-10-13" version="1">MGLTTAQAIGIGVAVGFVGALSLMMILLCISRCSSAETVPSGPIIIPAGTPPRVKQLKPNPRVLTAPRDPASFRNPSPTRTERCPTAWSLMSRHPSLMKMNLSASQESPPTAGLGPRPSPTSPQGALQSSASLRNSSLSACIPAAPFKSPYSLQRFQAVINSINRAIGENIIGVWRECVYLLQACPWHLDHVPSWRFFGNDPRRERTWAMVPDIVNSLRLESLRNDFHPKEGELEACIGQTLEKAANSAMILLGQPSEWEAVWTSPEPGFIVFPEVRFTWNGKTKYSKPAEVDVTVPKPVPSDNHDQPHAATGEQHSSDVGCQSDADADEQQKHVGAQALSLDTFQQTGAGNAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z262</accession>
    <name>C7Z262_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">beta-fructofuranosidase</fullName>
            <ecNumber evidence="2">3.2.1.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_96948</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.26" evidence="2"/>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU41948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047661.1">
        <property type="nucleotide sequence ID" value="XM_003047615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z262"/>
    <dbReference type="STRING" id="660122.C7Z262"/>
    <dbReference type="GeneID" id="9671614"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_96948"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_96948"/>
    <dbReference type="eggNOG" id="KOG0228">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042071_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z262"/>
    <dbReference type="OMA" id="ELVRHDN"/>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004564">
        <property type="term" value="F:beta-fructofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08995">
        <property type="entry name" value="GH32_EcAec43-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051214">
        <property type="entry name" value="GH32_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43101">
        <property type="entry name" value="BETA-FRUCTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43101:SF1">
        <property type="entry name" value="BETA-FRUCTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="6">
        <location>
            <begin position="32"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU41948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="521" mass="58596" checksum="1111CAA65FC681B7" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z293</accession>
    <name>C7Z293_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_50703</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the PTH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU41961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047674.1">
        <property type="nucleotide sequence ID" value="XM_003047628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z293"/>
    <dbReference type="FunCoup" id="C7Z293">
        <property type="interactions" value="119"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z293"/>
    <dbReference type="GeneID" id="9671632"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_50703"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_50703"/>
    <dbReference type="eggNOG" id="KOG2255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062456_2_0_1"/>
    <dbReference type="InParanoid" id="C7Z293"/>
    <dbReference type="OMA" id="PSYMNES"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="entry name" value="Peptidyl-tRNA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224:SF1">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="Peptidyl-tRNA hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU41961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="198" mass="22333" checksum="B38FAD3D7EDAC700" modified="2009-10-13" version="1">MFSPRFLVVSLGNPLPQYESLHSAGHFALNGLAKVLRYPSFREVTLGKKACLVSQGPKYTLVQSPTLMNISGSFVARAWQDMVKQHDPSSLSLVIVHDELEKDLGIVRLTAWDRSHKGHNGIKSVKGSLSQGKYPDSPFVRIALGIGRPKERDPETVSRYVLDRISGEQRRILEEEAPWKVAERLVELEDEWRTELKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z2I6</accession>
    <name>C7Z2I6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_54161</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047197.1">
        <property type="nucleotide sequence ID" value="XM_003047151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z2I6"/>
    <dbReference type="GeneID" id="9676373"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_54161"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_54161"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_2_1_1"/>
    <dbReference type="InParanoid" id="C7Z2I6"/>
    <dbReference type="OMA" id="AISISWC"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000247">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF65">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="100"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU41484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="559" mass="64197" checksum="F6EAF8B217978369" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z323</accession>
    <name>C7Z323_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_53975</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047470.1">
        <property type="nucleotide sequence ID" value="XM_003047424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z323"/>
    <dbReference type="STRING" id="660122.C7Z323"/>
    <dbReference type="GeneID" id="9675903"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_53975"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_53975"/>
    <dbReference type="eggNOG" id="KOG1290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_81_1_1"/>
    <dbReference type="InParanoid" id="C7Z323"/>
    <dbReference type="OMA" id="VCEASQM"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="97"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU41757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="448" mass="51067" checksum="8D0E9A02B8DE1726" modified="2009-10-13" version="1">MAFARLPFSSSRIYSHSIPSLHAHLLAARSPSWPLSRLGTSLALFSTARPRSEPRTFPTQGFDVIDKDQSIEEEDMPEYNPDHFYPVRLGEVFNGRFQIVAKLGFGSSSTIWLTRDLDVTRLTVSERDHQYVALKVYIHNSVEHRELPFYERLNAVLLTSKHVGADNVRRLMASFQVSGPHGSHIVLALQVSQMSLRDMDTVFMKGRGFDEDFVKSAIKELLQAVDFLHTEAQVVHTDIHPGNLLLGLEDNSLFKKLEDNEFSNPVPRKELPDRNIYFSRLMKPKVGPLLLSDFGEVRLGAGPHAGDIMPIMYRAPETLLYIQWSYPVDIWSVGLTAWDLLEGRTLFSARKEDGSFSDGVHLSELIAALGPPPADLLNRHRKRALEYWNEDYKWDEFVPIPKEKTLEAAETKLEDKTKFLAFMRRALAWDPNDRPTAKELLKDPWLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4T5</accession>
    <name>C7Z4T5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_33630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046693.1">
        <property type="nucleotide sequence ID" value="XM_003046647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4T5"/>
    <dbReference type="FunCoup" id="C7Z4T5">
        <property type="interactions" value="347"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z4T5"/>
    <dbReference type="GeneID" id="9678498"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_33630"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_33630"/>
    <dbReference type="eggNOG" id="KOG4727">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067237_2_0_1"/>
    <dbReference type="InParanoid" id="C7Z4T5"/>
    <dbReference type="OMA" id="VDHRRKW"/>
    <dbReference type="OrthoDB" id="30343at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040107">
        <property type="entry name" value="Snu23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="162"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU40980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="238" mass="27440" checksum="0B81C1040DCCB433" modified="2009-10-13" version="1">MSDSKKGGAYGDAPSGDTDFRKTWDLDEYAAKAKEREAKEKEEGKARYEAKLAGKKYYKPLTGDETYTSARRNVIDLTQQVGKTQLVPAGAGVGKRGRGAGFYCEACDLTFKDNKQFVEHLNTPQHLLNTGQTTEVKRATAEEVHQRIEYFIRRREDLEKEKQTSLHERLQLREEEAEKEAEERRKKRKEENERKKAKREEESKVKMEYGDDIRIEGEHDEDDMMAQMGFTGFGTSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4U2</accession>
    <name>C7Z4U2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Peroxisomal hydratase-dehydrogenase-epimerase</fullName>
            <ecNumber evidence="5">1.1.1.n12</ecNumber>
            <ecNumber evidence="6">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Multifunctional beta-oxidation protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">NECHADRAFT_66627</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Second trifunctional enzyme acting on the beta-oxidation pathway for fatty acids, possessing hydratase-dehydrogenase-epimerase activities. Converts trans-2-enoyl-CoA via D-3-hydroxyacyl-CoA to 3-ketoacyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32711"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.n12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.n12" evidence="5"/>
    <dbReference type="EC" id="4.2.1.119" evidence="6"/>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046119.1">
        <property type="nucleotide sequence ID" value="XM_003046073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4U2"/>
    <dbReference type="FunCoup" id="C7Z4U2">
        <property type="interactions" value="288"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z4U2"/>
    <dbReference type="GeneID" id="9678502"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_66627"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_66627"/>
    <dbReference type="eggNOG" id="KOG1206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_18_0_1"/>
    <dbReference type="InParanoid" id="C7Z4U2"/>
    <dbReference type="OMA" id="GKTRWQR"/>
    <dbReference type="OrthoDB" id="3592703at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018812">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03448">
        <property type="entry name" value="HDE_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05353">
        <property type="entry name" value="hydroxyacyl-CoA-like_DH_SDR_c-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000410">
        <property type="entry name" value="Peroxisomal multifunctional beta-oxidation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000013">
        <property type="entry name" value="Peroxisomal multifunctional enzyme type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000185">
        <property type="entry name" value="peroxisomal multifunctional enzyme type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051687">
        <property type="entry name" value="Peroxisomal_Beta-Oxidation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024:SF2">
        <property type="entry name" value="SCP2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ketoreductase" evidence="22">
        <location>
            <begin position="315"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="753"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00055743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00073871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00081853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EEU40406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="897" mass="96580" checksum="14D810CA9F41FF32" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4W3</accession>
    <name>C7Z4W3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase S8/S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_76658</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046130.1">
        <property type="nucleotide sequence ID" value="XM_003046084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4W3"/>
    <dbReference type="GeneID" id="9678236"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76658"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76658"/>
    <dbReference type="eggNOG" id="ENOG502SP4W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009240_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z4W3"/>
    <dbReference type="OMA" id="FATWENG"/>
    <dbReference type="OrthoDB" id="3565018at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186:SF4">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="DUF7580" evidence="3">
        <location>
            <begin position="164"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="2">
        <location>
            <begin position="586"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="592"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="625"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU40417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="817" mass="91586" checksum="453627B8453A3D5C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4X6</accession>
    <name>C7Z4X6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_99315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046136.1">
        <property type="nucleotide sequence ID" value="XM_003046090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4X6"/>
    <dbReference type="STRING" id="660122.C7Z4X6"/>
    <dbReference type="GeneID" id="9678242"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_99315"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_99315"/>
    <dbReference type="eggNOG" id="ENOG502RPP8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_494344_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z4X6"/>
    <dbReference type="OMA" id="FEVFMPC"/>
    <dbReference type="OrthoDB" id="3511049at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU40423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="575" mass="65304" checksum="0CDDB3A497E5A0CC" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4Z2</accession>
    <name>C7Z4Z2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_103510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046143.1">
        <property type="nucleotide sequence ID" value="XM_003046097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4Z2"/>
    <dbReference type="FunCoup" id="C7Z4Z2">
        <property type="interactions" value="151"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z4Z2"/>
    <dbReference type="GeneID" id="9678249"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_103510"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_103510"/>
    <dbReference type="eggNOG" id="KOG2655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017718_7_4_1"/>
    <dbReference type="InParanoid" id="C7Z4Z2"/>
    <dbReference type="OMA" id="GYDSAMN"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000328">
        <property type="entry name" value="Septin spn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="38"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU40430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="405" mass="45986" checksum="31954C5346989929" modified="2009-10-13" version="1">MPLERPSLNLTRILLSLLLASFNIFPLKMIRRKKNVKKGIQFCLMVCGASGTGRTTFVNTLCGKSVLDHKESDDAGSAHVEDGVKIKPITVELELDEEGTRISLTIVDTPGFGDQIDNEASFSEIVGYLERQYDDILAEESRIKRNPRFRDNRVHAMLYFITPTGHGLRELDIELMKRLAPRVNVIPVIGRADSLTPAELAESKKLVMEDIEHYRIPVYNFPYDIEEDDEDTVEENAELRGLMPFAIVGSEEVVEIGGRKVRARHYPWGVVEVDNPRHSDFLAIRSALLHSHLADLKEITHDFLYENYRTEKLSKSVEGAAGNADSSMNPEDLASQSVRLKEEQLRREEEKLREIELKVQREINEKRQELLARESQLREIEARMQREAAAQASGTPEPNGEEPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z506</accession>
    <name>C7Z506_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_91235</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046149.1">
        <property type="nucleotide sequence ID" value="XM_003046103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z506"/>
    <dbReference type="FunCoup" id="C7Z506">
        <property type="interactions" value="260"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z506"/>
    <dbReference type="GeneID" id="9678536"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_91235"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_91235"/>
    <dbReference type="eggNOG" id="KOG1305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009020_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z506"/>
    <dbReference type="OMA" id="DSIHHQR"/>
    <dbReference type="OrthoDB" id="438545at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015194">
        <property type="term" value="F:L-serine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF678">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="242"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="11">
        <location>
            <begin position="32"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="417"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="435"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU40436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="519" mass="56238" checksum="4604E746FD3BFDE2" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z546</accession>
    <name>C7Z546_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">T-complex protein 1 subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_58465</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU41037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046750.1">
        <property type="nucleotide sequence ID" value="XM_003046704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z546"/>
    <dbReference type="FunCoup" id="C7Z546">
        <property type="interactions" value="1294"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z546"/>
    <dbReference type="GeneID" id="9678555"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_58465"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_58465"/>
    <dbReference type="eggNOG" id="KOG0357">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_7_2_1"/>
    <dbReference type="InParanoid" id="C7Z546"/>
    <dbReference type="OMA" id="SHPQMPH"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03339">
        <property type="entry name" value="TCP1_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000053">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000003">
        <property type="entry name" value="T-complex protein 1 subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012718">
        <property type="entry name" value="Chap_CCT_epsi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02343">
        <property type="entry name" value="chap_CCT_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU41037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="552" mass="59968" checksum="B00C5FD4D2E4A716" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z609</accession>
    <name>C7Z609_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_75937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046329.1">
        <property type="nucleotide sequence ID" value="XM_003046283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z609"/>
    <dbReference type="STRING" id="660122.C7Z609"/>
    <dbReference type="GeneID" id="9678434"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75937"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75937"/>
    <dbReference type="eggNOG" id="ENOG502RQN7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_819128_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z609"/>
    <dbReference type="OrthoDB" id="412402at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU40616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="339" mass="39934" checksum="325828143A3AD8CC" modified="2009-10-13" version="1">MYDEPNHFWHDHDTHSHGSRRNDFIPNNFCTQCRPWRNKFGEFIIPWQFYQRERPGFYLADVVAGPPGVDKLLCGWPKIADPNRPLIGFEVSVKSGIGSGAANLLAKKMATLVMVLEPLLLKLVAPGRWPWVTRELTEYTYFPWFPDCSVKYGYDSHVPPMVATKPEVANGGEPEYMDTMLKMTWGAPSLCELDSRLLTSPQLYYGFSLSLSKEHWMYKDPRPCQSREYVFEDDYRQYSFHESRRQQNLEEGWSSFCFKHLQTTSDDVLLRNWVEVIIQIVELAMASPDEYKRCLEVIFRIQHDDNHDGTAWELLMRQVLKLEHRILYWTRQMDKYGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z675</accession>
    <name>C7Z675_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_76004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046361.1">
        <property type="nucleotide sequence ID" value="XM_003046315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z675"/>
    <dbReference type="GeneID" id="9668551"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76004"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76004"/>
    <dbReference type="eggNOG" id="ENOG502R1YG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012207_3_0_1"/>
    <dbReference type="InParanoid" id="C7Z675"/>
    <dbReference type="OMA" id="IICAVAN"/>
    <dbReference type="OrthoDB" id="3692311at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU40648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="535" mass="58122" checksum="BC8DA5A0108621A4" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z781</accession>
    <name>C7Z781_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_12700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046539.1">
        <property type="nucleotide sequence ID" value="XM_003046493.1"/>
    </dbReference>
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    <dbReference type="STRING" id="660122.C7Z781"/>
    <dbReference type="GeneID" id="9668954"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_12700"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_12700"/>
    <dbReference type="eggNOG" id="KOG0342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_26_6_1"/>
    <dbReference type="InParanoid" id="C7Z781"/>
    <dbReference type="OMA" id="TQREGCH"/>
    <dbReference type="OrthoDB" id="193716at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="75"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="302"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU40826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="560" mass="61891" checksum="E21491F9056ADAA4" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7E2</accession>
    <name>C7Z7E2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_66377</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046571.1">
        <property type="nucleotide sequence ID" value="XM_003046525.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="C7Z7E2">
        <property type="interactions" value="721"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z7E2"/>
    <dbReference type="GeneID" id="9668983"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_66377"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_66377"/>
    <dbReference type="eggNOG" id="KOG0706">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023062_7_0_1"/>
    <dbReference type="InParanoid" id="C7Z7E2"/>
    <dbReference type="OMA" id="PANQVCF"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08831">
        <property type="entry name" value="ArfGap_ArfGap2_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000013">
        <property type="entry name" value="Putative Arf GTPase-activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="8"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="143"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="277"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU40858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="479" mass="51043" checksum="E0A586372A5D05BC" modified="2009-10-13" version="1">MSALATKQQSLKIFEKLKTKPTNKICFDCGQKNPTWTSVPFGIYLCLDCSANHRNLGVHISFVRSTNLDQWQWDQLRMMKVGGNESATKFFQQNGGTAALNSKDPKTKYQSNAATKYKDELKRRAARDAQEFPDEVVITDAVDDGSATPAGEPDDDFFSSWDKPAIKKPTPPVSRTATPPVMGRTPSPFLNAGNGKDIARASSPLARTASSESKPASRITTSAALRKTGGGIGGPRKANVLGAKKTTKLGAKKVTSDAIDFDEAERKAKEEADRIAKLGYDPDAEEDPATKAATGSAAAIISPTPVSPNKSSYSSHTRQKSDAEVERLGMGMGRLGFGQIGGPKAAAAPKKNAGGFGSVGPVKAAAVDDSERYARDKFGAQKGISSDEFFGKGAFDPNAQAEAKTRLQGFEGASAISSNAYFGRPEDEPEEEYGDLESAAKDFVRKFGITAGDDLENLTQMAGEVSSRLQGAIRSYLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7I5</accession>
    <name>C7Z7I5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine protein phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_33738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046022.1">
        <property type="nucleotide sequence ID" value="XM_003045976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7I5"/>
    <dbReference type="GeneID" id="9668376"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_33738"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_33738"/>
    <dbReference type="eggNOG" id="ENOG502SN7S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094654_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z7I5"/>
    <dbReference type="OMA" id="YMRYSGH"/>
    <dbReference type="OrthoDB" id="5409477at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU40309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="24739" checksum="EB54595DEEB6F888" modified="2009-10-13" version="1">MDPDCAICHAPASMACDCEAKGLDVAVKQAEDRMMRSIYTEIRSWVRGHAQDYILEYFRLLTDQRKTAHSAHLDRITAHAYHYYHAPPHPTQIAEAQASLKRGIDEDWQASVQRYPEVLEYFFGLVELTLPAEDEPAVKDPPLGSLSNFRKVNRRSGSGGAGGGGPVPGGSAAVAPVGYRDPAALHSQTPPPMPRLDRRTPGPRERRPAGFGPPPPPPAASYYPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7X7</accession>
    <name>C7Z7X7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_79593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045615.1">
        <property type="nucleotide sequence ID" value="XM_003045569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7X7"/>
    <dbReference type="STRING" id="660122.C7Z7X7"/>
    <dbReference type="GeneID" id="9672515"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79593"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79593"/>
    <dbReference type="eggNOG" id="ENOG502RBJ4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_552186_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z7X7"/>
    <dbReference type="OMA" id="KQRLWGY"/>
    <dbReference type="OrthoDB" id="6079484at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988567" description="Peptidase A2 domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="54977" checksum="1C1307AAAF11F9D0" modified="2009-10-13" version="1">MASALGIPPGVSAIFSLFITRALAEARETTKTWLPDDDKFNSWLGFSPSKGEFWLTGTLGRGKSTRLRTGARSRSQRETDQRHLAKLGVTLAPQLAVSAPVLSPQVKDAIDADSANSYTWGRIGEYNTVPRDLKDYSVKAKVGKHHVDALPDTGAQCNLISLQLAEKAGLVPRKGTEQAIRLPTGKQVSSPGAVRIPFSFLGEAKEYMLKCWIIPGCNRDLILSREFLDATKTLTKFIHRITSKIRKVTRRHRLNLLGDERQRIWGGVNNSLALALPDTGSDVMLVSAEYTRRNNLDVERGPEHQLELGFGDGSTAFTTGVVRNAEWAFGDSGQKVLCDLYVLDDLSVDVVLSGDFVFEFGVFDRFSRFLVHLDSLPDLSELYNIRLIGKYSPELQRLETLCYNDLNSPHAFSPRAVKAERVRRDQIRDAINALPSAEQAESWVAEHRRQELWEGFRAKHRPKQGAMTTSSVPSLRTLPGQCQKRVSERATAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z841</accession>
    <name>C7Z841_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF2306 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_39206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045642.1">
        <property type="nucleotide sequence ID" value="XM_003045596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z841"/>
    <dbReference type="STRING" id="660122.C7Z841"/>
    <dbReference type="GeneID" id="9672542"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_39206"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_39206"/>
    <dbReference type="eggNOG" id="ENOG502RYBX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054818_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z841"/>
    <dbReference type="OMA" id="FHRANGY"/>
    <dbReference type="OrthoDB" id="193478at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018750">
        <property type="entry name" value="DUF2306_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10067">
        <property type="entry name" value="DUF2306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="33230" checksum="84924E1FEEFB4885" modified="2009-10-13" version="1">MPALRQALGFSRGRSLALFILFGGAMSLFSILQLPFIDIDNVFCGKDPWATPGECYWFGRPGINKLGMRLHLATFLPAGALVGWQFVPASRRPHLAKYHRINGYVVLVLSALGTVGALIIEKRAMGGPFSARIGTWIIAVSFTTAMVMGVVSIKKRQFDQHRAWMLRGWFYAGAIISMRIVLIAVAIIVGQHGWLYRPLQCAVIEYLGEFNPDGVKPLYPNCTSYLAGEDPGQEVLVRTNWDFNDLPGMAVALRYGYLFGGWTAFTLHAVGVEIYVSETILCLRTLRFANRYSVTKNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8H9</accession>
    <name>C7Z8H9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ARB-07466-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_94258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045049.1">
        <property type="nucleotide sequence ID" value="XM_003045003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8H9"/>
    <dbReference type="STRING" id="660122.C7Z8H9"/>
    <dbReference type="GeneID" id="9673491"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94258"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94258"/>
    <dbReference type="eggNOG" id="ENOG502RZ4I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109885_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z8H9"/>
    <dbReference type="OMA" id="IREIGCK"/>
    <dbReference type="OrthoDB" id="2251794at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058593">
        <property type="entry name" value="ARB_07466-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26571">
        <property type="entry name" value="VldE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988908" description="ARB-07466-like C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="ARB-07466-like C-terminal" evidence="2">
        <location>
            <begin position="110"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU39336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="232" mass="24043" checksum="9E4F5F8B278AF696" modified="2009-10-13" version="1">MMMIVFVTLAASNEPCYGPNGIAGVCITDAACTSAGGTSISGACPADAANIKCCSKPSCANGASGNCRWTSDCAGSSVTNQCPGPGQMRCCSAGGSGFGGYPAPNIPAVGACKQVAVDGAKKVVAAFPGRVREIGCKRDCSCPGSSDHCCGLATDFMCADGGGSATLSGKEIAEWCMRNRATLNLKYVIWGQKIWTTSVDGTNKNWESWRTMEDRGDLTQNHWDHVHVSYNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8S7</accession>
    <name>C7Z8S7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tryptophan synthase beta chain-like PALP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_42931</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ACC deaminase/D-cysteine desulfhydrase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044736.1">
        <property type="nucleotide sequence ID" value="XM_003044690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8S7"/>
    <dbReference type="STRING" id="660122.C7Z8S7"/>
    <dbReference type="GeneID" id="9673646"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_42931"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_42931"/>
    <dbReference type="eggNOG" id="ENOG502QPS1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048897_2_1_1"/>
    <dbReference type="InParanoid" id="C7Z8S7"/>
    <dbReference type="OMA" id="YRKLKYN"/>
    <dbReference type="OrthoDB" id="10266364at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019148">
        <property type="term" value="F:D-cysteine desulfhydrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43780">
        <property type="entry name" value="1-AMINOCYCLOPROPANE-1-CARBOXYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43780:SF2">
        <property type="entry name" value="1-AMINOCYCLOPROPANE-1-CARBOXYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="6">
        <location>
            <begin position="23"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU39023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="340" mass="36288" checksum="34040155D5AE3B50" modified="2009-10-13" version="1">MAKLPSPFSDIPRVKLMFDRPVDIEPLSRLTESLDCGARVWILREDRNSGLAFGGNKVRKLEYVLADALAQGADTLVTTGGIQSNHMCQTSAAAARLGLQVALYAKDSVASNDAEYKYTGNVQANSIFGAETFPIGTSEETVIKTLKERGRTPYSIPTGASTHPLGGLGFARWAFELLEQETKLGVTFDVIVSATGSCSTLGGMVAGFKLAEKLGYPNSKKRLLGFSILNPSEQEVVSLVLTIAKTAASKIGLSPDDITKDDFEIDTSYLGGAYGNLDERTSDGVKELARLEGILTDPVYTGKALTGLLHTARAGAFKDKNVLFCHTGGQAALAAYPRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAW8</accession>
    <name>C7ZAW8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_83044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044379.1">
        <property type="nucleotide sequence ID" value="XM_003044333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAW8"/>
    <dbReference type="GeneID" id="9670702"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83044"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83044"/>
    <dbReference type="eggNOG" id="ENOG502SUZR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_774082_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZAW8"/>
    <dbReference type="OMA" id="ITPKFAP"/>
    <dbReference type="OrthoDB" id="3562088at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988674" evidence="1">
        <location>
            <begin position="21"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="358" mass="38424" checksum="1A3780BC88925DD0" modified="2009-10-13" version="1">MRNNVLLAVALAAVGSNAAALSPPLVERAACNRDNLFRCFIDQRYSVQASEFCANLSPSTVTVATITATETTTVETELTADVATSTEILTTTVFTETIATATTTVTFDPDVLAKRDASVNPPKCMTNGVSYPASRITSACSCIDVPASTVSVTYVAGTETVTETSTVFTTPSPATITTWTTVSTAAARVQTVTVAPTGTTNRLSFQNGTMNGWELLPTTWPGEMRKGIINGGTEWSFNFFPMDNSLATLRYLPLVYMEAGRYQVGFTSYLLQFPAPTGPWGQYFVFDIVNPSKGTNITVTFPQVAPKKVLNKRIVTSVQNTVDIPESAAGYSQITVRWIATPQWALTALNNLAVEKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBB1</accession>
    <name>C7ZBB1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_45867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044398.1">
        <property type="nucleotide sequence ID" value="XM_003044352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBB1"/>
    <dbReference type="STRING" id="660122.C7ZBB1"/>
    <dbReference type="GeneID" id="9670721"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45867"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45867"/>
    <dbReference type="eggNOG" id="KOG0742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004471_2_3_1"/>
    <dbReference type="InParanoid" id="C7ZBB1"/>
    <dbReference type="OMA" id="HENARWN"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056599">
        <property type="entry name" value="AAA_lid_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23232">
        <property type="entry name" value="AAA_lid_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="563"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="820"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="868"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="903"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU38685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="923" mass="106981" checksum="6FB320C5010E6D9B" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBH2</accession>
    <name>C7ZBH2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_83179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044569.1">
        <property type="nucleotide sequence ID" value="XM_003044523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBH2"/>
    <dbReference type="STRING" id="660122.C7ZBH2"/>
    <dbReference type="GeneID" id="9672753"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83179"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83179"/>
    <dbReference type="eggNOG" id="ENOG502RQW1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115021_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZBH2"/>
    <dbReference type="OMA" id="ISHTWRH"/>
    <dbReference type="OrthoDB" id="5020929at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="216" mass="24094" checksum="963CCCDE6E9900A6" modified="2009-10-13" version="1">MATPPTLSTPRLSYPWTFSLAKVLENSVGPLPCPVATQGAELVPPPETPALRYPPPDPAFVETLTERLEKLAWRQRIRINVYGVDFAEEWPISRTPRLLAEEAAARRIAFLEKDLHLDSSSTSESEGENERRILRLKKMLRRSRKQTRPRGAQLPSPQSTTEEEAGEQTPAAKPCLKRKRSKVLFEPTKMAKTSKELAVSRINLPSTANGGEAPMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBS4</accession>
    <name>C7ZBS4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_88511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698915">
        <property type="protein sequence ID" value="EEU38568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044281.1">
        <property type="nucleotide sequence ID" value="XM_003044235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBS4"/>
    <dbReference type="GeneID" id="9670650"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88511"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88511"/>
    <dbReference type="HOGENOM" id="CLU_1611232_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZBS4"/>
    <dbReference type="OrthoDB" id="5089751at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="165" mass="17825" checksum="586CEEEF45ECD1AE" modified="2009-10-13" version="1">MSSPLFTQSFLDEDELKLRSQNRSARERRGHKQRIRRSRESVSGGVTGPGSASSTTAPRSSIEAATPTEPGQEPTTPTRVVPCTPSSSARSEGDEWHEQRRKVNKSPVTIVVNITTSGEHATDTPTARSNSSFYIKIQLGPTSEVRLEGSDWAVTGINVVGETGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCH8</accession>
    <name>C7ZCH8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_77057</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698918">
        <property type="protein sequence ID" value="EEU38264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043977.1">
        <property type="nucleotide sequence ID" value="XM_003043931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCH8"/>
    <dbReference type="GeneID" id="9670410"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77057"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77057"/>
    <dbReference type="eggNOG" id="ENOG502S5BG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010915_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZCH8"/>
    <dbReference type="OMA" id="CPCSPEG"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="585"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="734"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU38264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1104" mass="124460" checksum="F4ECCB944F587ABB" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDC6</accession>
    <name>C7ZDC6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Uric acid-xanthine permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_48122</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
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            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_48122"/>
    <dbReference type="eggNOG" id="ENOG502QQD4">
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        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:xanthine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="NCS2"/>
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        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
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        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810:SF2">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="XANTH_URACIL_PERMASE"/>
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    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="97"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="288"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="356"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="448"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="525"/>
            <end position="547"/>
        </location>
    </feature>
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        <location>
            <begin position="562"/>
            <end position="591"/>
        </location>
    </feature>
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        <location>
            <begin position="566"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEU38194.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="591" mass="62835" checksum="4941D52E9EEA05C7" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDU1</accession>
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            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
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        <name evidence="3" type="ORF">NECHADRAFT_88131</name>
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        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
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            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="9669603"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88131"/>
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            <end position="284"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEU37751.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="875" mass="98793" checksum="7DF0CD198EABCEC4" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEJ6</accession>
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        <recommendedName>
            <fullName evidence="2">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">NECHADRAFT_53536</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
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                <person name="Salamov A."/>
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                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
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    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_53536"/>
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    <dbReference type="OMA" id="RDSTNAW"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF54">
        <property type="entry name" value="FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="61"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU37608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="349" mass="39118" checksum="770CCC06BF6289A5" modified="2009-10-13" version="1">MSLPTGFPEQLKGPMAWDASDFVQNPEAYTLTLTESDLLGIRTAVNHFKGLGLPRGSVDRSNFPLPEALITKFRQINDTLNNGHGFQVVRGIDPTSYSEEEHILIFAGICAHVATHRNWFIGMFIKDFHTDVDSGPILALFMEKQSKYGGNQHLSSFWTIYNSLARESPEVIRELASNWHWEMPDKENLDGPNIVLPSRPIIGKADGRLQINFAKAYLANHPQYPMNKGSPSLSPSQEAALKILTETARRHSLQLDTKAGDLVLVNNLAMMHARDAFVDDVVSGDVRHVLRLWLQDQDSWPVASSLGYIEPEKTWHVSDKHQSLRTLSEWVTLPRPIRAVDAAASQKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEM5</accession>
    <name>C7ZEM5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_86278</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043155.1">
        <property type="nucleotide sequence ID" value="XM_003043109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEM5"/>
    <dbReference type="GeneID" id="9665260"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86278"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86278"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="InParanoid" id="C7ZEM5"/>
    <dbReference type="OMA" id="RIRHRNT"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="15"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU37442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="510" mass="55543" checksum="651EAA37C08FC624" modified="2009-10-13" version="1">MAVPQLTGRPLQALVYATAGAAFLLFGYDQGVMGGLVSLESFIQRFNSPSPGLLGFMVASYDVGCLLGAVFAFLRGDKLGRRWSIIYSCIIVLIGATLQTAAYSRAQYIVGRIVAGVGVGCISVTVPIYASECASASSRGKLVVVETTIVIIGITISNFTNFGFVFGRPELNGKEAQWRIPLGLQMIFPPFVFLLMPFVVESPRWLAAVGRSDEVADVLAKLRGGGATADSPQIQQQARRIIETAAHEAELESSWKESFAGGELQNLRRLILAGSTGFLHQATGINVVIYYAPVIFRQVGLDDKMSYIMSCVGSICFLVGSILPVLYIERIGRRKTMMLGAWTCGICMGMIACTGAIGRYYPARAFATGWAGSAFVLLFQFSFGIGWNSMNWLYASEIGSLRMRNKTAAVQCFCHWGTNFLTVMVAPTGFASLGWRFYLVWMSVTLAAIPYLYFCFPETAGRSLEQMDDFFKTYPQWNIGKVANVWVDLGGAGGQDSCKEEAGAVHHQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEP5</accession>
    <name>C7ZEP5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Laccase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_86298</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043081.1">
        <property type="nucleotide sequence ID" value="XM_003043035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEP5"/>
    <dbReference type="STRING" id="660122.C7ZEP5"/>
    <dbReference type="GeneID" id="9665180"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86298"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86298"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_3_2_1"/>
    <dbReference type="InParanoid" id="C7ZEP5"/>
    <dbReference type="OMA" id="MAPAGGY"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF71">
        <property type="entry name" value="OXIDOREDUCTASE TPCJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988057" description="Laccase" evidence="7">
        <location>
            <begin position="26"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="115"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="238"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="480"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU37368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="653" mass="74554" checksum="6F89B6BC1A3AB8E0" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEY9</accession>
    <name>C7ZEY9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_51327</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043100.1">
        <property type="nucleotide sequence ID" value="XM_003043054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEY9"/>
    <dbReference type="STRING" id="660122.C7ZEY9"/>
    <dbReference type="GeneID" id="9665299"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51327"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51327"/>
    <dbReference type="eggNOG" id="ENOG502SHDE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007003_7_1_1"/>
    <dbReference type="InParanoid" id="C7ZEY9"/>
    <dbReference type="OMA" id="RKVTWWG"/>
    <dbReference type="OrthoDB" id="2154091at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF83">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
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    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="253"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU37387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="625" mass="70416" checksum="0DE3436B7F9778B4" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZF71</accession>
    <name>C7ZF71_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_86412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043233.1">
        <property type="nucleotide sequence ID" value="XM_003043187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZF71"/>
    <dbReference type="GeneID" id="9665348"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86412"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86412"/>
    <dbReference type="eggNOG" id="ENOG502T8PC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059036_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZF71"/>
    <dbReference type="OMA" id="VKMRRPW"/>
    <dbReference type="OrthoDB" id="5351891at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="397" mass="43699" checksum="CA9D34DB2C826245" modified="2009-10-13" version="1">MILDTCNSNSTTVGPAELGLTIADFSASLAHGEYCAKNASYVRPDDAGSILPWPYTLAWFLIHFPITLIRVHRWERVQALSIILAVTTVWFQLQAYTSSIEPEAVLVWMPIFVVLDIGAMMQLVFLIVEDTGFWPLVRALPDFLPLSARRSSTASSTVVGSEEVRIEGSGKTATPTPLPPSWTELNREPASSELVGRAWLALLSFVLGILLLSIQLFGLAMAIKGFHSDHVTAQWCSTFFATAVAVESDCKLYDVTPSLSQGIGCITIKGYEQYTWLQASIIIISLSLAFQVFDCTIMTLVSGTTRWRGAKMKRPWFTMFTGNIVLLVLIVVGVFQSQRLPRDVSPSVLVYKHGRGLGNSNHTCIGELTPYGVRGAIIGWTDGFLESWGDTYSPKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZG53</accession>
    <name>C7ZG53_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trichothecene 3-O-acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_52215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698924">
        <property type="protein sequence ID" value="EEU37020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042733.1">
        <property type="nucleotide sequence ID" value="XM_003042687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZG53"/>
    <dbReference type="GeneID" id="9664934"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_52215"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_52215"/>
    <dbReference type="eggNOG" id="ENOG502SHDQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026450_2_1_1"/>
    <dbReference type="InParanoid" id="C7ZG53"/>
    <dbReference type="OMA" id="NWISTYD"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF64">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="53097" checksum="9F71C8D2F0170C6E" modified="2009-10-13" version="1">MSPTGPSPVELCLHPSGWRSAPESERYPLSLMGHVMPKIYVAVAEVFTLPEGTNIEATVRNMTAGLEFTLSQFPILSGILEMNAATGTMWVAKKRDSTASLHVKHMLGEDEFPSYKELAEKHFPASALKGGQLLPEFVTAKPLHSPLGDNNEEGIAVAAFQLNFIRDGLIIALAIHHSVSDGPGCDGFLTTWAENTVAAAKGTPFIPTKHKFSIHGTPLDIERPSMARVEELDKMLPVVRDAGGPMQPPPAGFVMPTLVAQMWHFPKSKVDLLKSKASNQDGGSWISTYDAIMALLWSSITRAKLEMFKPDPESKAILVHAVDTRKVWSPSLPDRFLGVGAAAARCEPLAVKDIITGNLSQLAASVRGSINAITPEYLSNLLEWVAGHEDQRFLETSINSFLGIDLGASSWQGMTTYEAHDFGFGLPKALRWPNPGFEGFVLLYPSRAGSVDAAEDEGIEVCVCLEESCHKRLLEDEVLLEYAQPRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZGC7</accession>
    <name>C7ZGC7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_42185</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698925">
        <property type="protein sequence ID" value="EEU36801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042514.1">
        <property type="nucleotide sequence ID" value="XM_003042468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZGC7"/>
    <dbReference type="GeneID" id="9669844"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_42185"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_42185"/>
    <dbReference type="eggNOG" id="ENOG502S3IW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012260_3_1_1"/>
    <dbReference type="InParanoid" id="C7ZGC7"/>
    <dbReference type="OMA" id="ITHTYIQ"/>
    <dbReference type="OrthoDB" id="447251at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429:SF9">
        <property type="entry name" value="PAS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0157">Chromophore</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="233"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="515"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="571"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="574"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU36801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="592" mass="66565" checksum="C5132A3295D2750D" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZGH1</accession>
    <name>C7ZGH1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative peptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_18806</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ZPS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698925">
        <property type="protein sequence ID" value="EEU36935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042648.1">
        <property type="nucleotide sequence ID" value="XM_003042602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZGH1"/>
    <dbReference type="FunCoup" id="C7ZGH1">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZGH1"/>
    <dbReference type="GeneID" id="9669985"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_18806"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_18806"/>
    <dbReference type="eggNOG" id="ENOG502RTN8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048223_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZGH1"/>
    <dbReference type="OMA" id="CNATQRR"/>
    <dbReference type="OrthoDB" id="4689212at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11307">
        <property type="entry name" value="M35_Asp_f2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000043">
        <property type="entry name" value="Major allergen Asp F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029482">
        <property type="entry name" value="HRXXH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039124">
        <property type="entry name" value="PRA1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39399">
        <property type="entry name" value="PROTEIN ZPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39399:SF1">
        <property type="entry name" value="PROTEIN ZPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13933">
        <property type="entry name" value="HRXXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Putative peptidase" evidence="4">
        <location>
            <begin position="11"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU36935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="249" mass="27469" checksum="AE95AE65E5697267" modified="2009-10-13" version="1" fragment="single">TTVAALLFGAAIASPIVPREEAATQTAEAPKATESAGAYDWAEGWKKAYPIHQSCNSTLHRQLANGLDEAVQLATHAKEHILRFGHKSEFVQKYFGNASTSQPIGWYERIINADKTGMLFRCDDPDRNCATQDEWAGHWRGDNATTETVICPLSFEIRRNLDQVCNRGYTVAASKLNTFWATDLMHRILHVPTVSEEVVDHFASAYTEVTALAKKNPEESVIDSNTLQFFAIDVYAYDIAAPGVGCTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZGK5</accession>
    <name>C7ZGK5_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_42034</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698925">
        <property type="protein sequence ID" value="EEU36907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042620.1">
        <property type="nucleotide sequence ID" value="XM_003042574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZGK5"/>
    <dbReference type="GeneID" id="9669937"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_42034"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_42034"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_0_1"/>
    <dbReference type="InParanoid" id="C7ZGK5"/>
    <dbReference type="OMA" id="VADEQWS"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963">
        <property type="entry name" value="CARBONYL REDUCTASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963:SF6">
        <property type="entry name" value="CHAIN DEHYDROGENASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU36907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="248" mass="25978" checksum="CD4439D25CF2EDE0" modified="2009-10-13" version="1">MASPKVVVLVTGANQGIGYCIAQQLASSGKYNVLVGARSSSKAEAAVQALQAEGINKTTLTPVAIDVTDDRSIAAAVQTVSDQAGHLDILINNAGLGTSTAATIREQYREIFEANVFGVAAVIDAFLPLIRASSFSDRRVVNVTSAVGLTTMASEEGFEYNAKSYYVPDYRSSKAAVNMITVAQSVKLAEYDIAVVAAAPGMCRTRFTGGYGMKDASEGARAIVRAATEGDPKKLTGTFVADEPHTGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZH30</accession>
    <name>C7ZH30_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">beta-glucosidase</fullName>
            <ecNumber evidence="9">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_86579</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="9"/>
    <dbReference type="EMBL" id="GG698927">
        <property type="protein sequence ID" value="EEU36649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042362.1">
        <property type="nucleotide sequence ID" value="XM_003042316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZH30"/>
    <dbReference type="STRING" id="660122.C7ZH30"/>
    <dbReference type="GeneID" id="9669528"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86579"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86579"/>
    <dbReference type="eggNOG" id="ENOG502SH7D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_4_0_1"/>
    <dbReference type="InParanoid" id="C7ZH30"/>
    <dbReference type="OMA" id="EVEPYYG"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF27">
        <property type="entry name" value="BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="10">
        <location>
            <begin position="398"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU36649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="841" mass="92366" checksum="F2590C6F56DD938B" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZH36</accession>
    <name>C7ZH36_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_105613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698927">
        <property type="protein sequence ID" value="EEU36652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042365.1">
        <property type="nucleotide sequence ID" value="XM_003042319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZH36"/>
    <dbReference type="GeneID" id="9669531"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_105613"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_105613"/>
    <dbReference type="eggNOG" id="ENOG502QSKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZH36"/>
    <dbReference type="OMA" id="CEKIGRT"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU36652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="35713" checksum="F88C96FF3717D7D0" modified="2009-10-13" version="1">MTDAQATPEVQVDDDVHNSITSSVLKYQWKYGRRYHSDRSGQYSFPNDDTEQDRLDMIHHVFYRLLGDRLFLAPIEPDGLNILDIGTGTGIWAIQFGDEHPSATVVGNDLSPIQPDWVPPNVKFVVDDVEMDWVEPIQYDYIHCRYMAGSIKDWPKLFKQAYANLKPGGWIEFQESANTLYSEDGSLAPENPMVQMMDNLILACDKIGRTMDPAPSFQRWAEETGFTELKEKRFKLPIGPWPKDQRLKEIGTLMGKNFYEGVAAFTAVLFTEALGWSREEVELFNASVREASRQRTVHPIFDFVVLIGRKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZH80</accession>
    <name>C7ZH80_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_51990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698927">
        <property type="protein sequence ID" value="EEU36618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042331.1">
        <property type="nucleotide sequence ID" value="XM_003042285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZH80"/>
    <dbReference type="GeneID" id="9669497"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51990"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51990"/>
    <dbReference type="eggNOG" id="ENOG502RVDG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004184_7_2_1"/>
    <dbReference type="InParanoid" id="C7ZH80"/>
    <dbReference type="OMA" id="RQGFKLW"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF77">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="103"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU36618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="746" mass="83799" checksum="430E274950FBA8A9" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJ55</accession>
    <name>C7ZJ55_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_49768</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698932">
        <property type="protein sequence ID" value="EEU36018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041731.1">
        <property type="nucleotide sequence ID" value="XM_003041685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJ55"/>
    <dbReference type="GeneID" id="9674072"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_49768"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_49768"/>
    <dbReference type="eggNOG" id="ENOG502QUDW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010539_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZJ55"/>
    <dbReference type="OMA" id="ENWGWYI"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645:SF3">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="554"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="622"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="662"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="697"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU36018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="740" mass="79850" checksum="755905A2E990B4C6" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJF8</accession>
    <name>C7ZJF8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell wall protein PhiA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_103636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698933">
        <property type="protein sequence ID" value="EEU35897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041610.1">
        <property type="nucleotide sequence ID" value="XM_003041564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJF8"/>
    <dbReference type="GeneID" id="9673981"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_103636"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_103636"/>
    <dbReference type="eggNOG" id="ENOG502SNZ2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097238_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZJF8"/>
    <dbReference type="OMA" id="WSIWADA"/>
    <dbReference type="OrthoDB" id="4093325at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052820">
        <property type="entry name" value="PhiA_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42047">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42047:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988896" description="Cell wall protein PhiA" evidence="1">
        <location>
            <begin position="19"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="19478" checksum="5739DC569D0015E1" modified="2009-10-13" version="1">MQFKTLLALPVLSGLAAAAPAADAAKTPGPFQILALRSASDIHFATVNAAKSSLFLHLPHSNATCDTKSDGAATFSLTEDGELYLYSTDNPPQKLYADRSGMGQGKLGYTTGAQPPPKNGEVKGWVIDKDGNLSLDGASLLACPNSIEGAWSIWVSAGVANPAGNEGCLGFSARTTEVEKPNSCTYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKD0</accession>
    <name>C7ZKD0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_88769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698938">
        <property type="protein sequence ID" value="EEU35536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041249.1">
        <property type="nucleotide sequence ID" value="XM_003041203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKD0"/>
    <dbReference type="GeneID" id="9675853"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88769"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88769"/>
    <dbReference type="eggNOG" id="ENOG502SI3E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_330397_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZKD0"/>
    <dbReference type="OrthoDB" id="5041285at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052761">
        <property type="entry name" value="Fungal_Detox/Toxin_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425:SF2">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="868" mass="97193" checksum="DB105BFE59917BFE" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKK2</accession>
    <name>C7ZKK2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_51186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698940">
        <property type="protein sequence ID" value="EEU35421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041134.1">
        <property type="nucleotide sequence ID" value="XM_003041088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKK2"/>
    <dbReference type="FunCoup" id="C7ZKK2">
        <property type="interactions" value="289"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZKK2"/>
    <dbReference type="GeneID" id="9675816"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51186"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51186"/>
    <dbReference type="eggNOG" id="ENOG502QQTI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007201_2_1_1"/>
    <dbReference type="InParanoid" id="C7ZKK2"/>
    <dbReference type="OMA" id="IWAEAST"/>
    <dbReference type="OrthoDB" id="2262349at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="647" mass="72239" checksum="1E5EF3480D9A6ED4" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMM2</accession>
    <name>C7ZMM2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_88881</name>
        <name evidence="1" type="ORF">NECHADRAFT_89190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">77-13-4</strain>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699100">
        <property type="protein sequence ID" value="EEU33343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GG698956">
        <property type="protein sequence ID" value="EEU34731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039056.1">
        <property type="nucleotide sequence ID" value="XM_003039010.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040444.1">
        <property type="nucleotide sequence ID" value="XM_003040398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMM2"/>
    <dbReference type="STRING" id="660122.C7ZMM2"/>
    <dbReference type="GeneID" id="9667206"/>
    <dbReference type="GeneID" id="9678871"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88881"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89190"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88881"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89190"/>
    <dbReference type="HOGENOM" id="CLU_120101_0_0_1"/>
    <dbReference type="OrthoDB" id="2895307at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU33343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="147" mass="16405" checksum="01D7D76E03D278E1" modified="2009-10-13" version="1">MRAGTDFEPRHSTDITLTAYRNAIDYLGYYRDTIGSIIDEPGQHDHLSKRVLADRSSKVIGVRINCRRDQATRHEPQMVEVAMPKTHPLFNLEGDDPCDIPLLFGLELIAKAYNSGLCKEDNGPPSNNLKNPLAELLLTTTSIKNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMT6</accession>
    <name>C7ZMT6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="15">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">NECHADRAFT_44658</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="15"/>
    <dbReference type="EMBL" id="GG698958">
        <property type="protein sequence ID" value="EEU34693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040406.1">
        <property type="nucleotide sequence ID" value="XM_003040360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMT6"/>
    <dbReference type="FunCoup" id="C7ZMT6">
        <property type="interactions" value="381"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZMT6"/>
    <dbReference type="GeneID" id="9678819"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_44658"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_44658"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020639_1_1_1"/>
    <dbReference type="InParanoid" id="C7ZMT6"/>
    <dbReference type="OMA" id="ASNKHDI"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF148">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5 17" id="KW-0349">Heme</keyword>
    <keyword evidence="10 17" id="KW-0408">Iron</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="19">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="20">
        <location>
            <begin position="100"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EEU34693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="462" mass="51623" checksum="FEC9BE0AB9EEA2B3" modified="2009-10-13" version="1">MALHPSEVAKHNNAKSCWLIIHNEVYDLTKFLPHHPGGRRVILMHAGRDATQRFNLVHSKDILDKWLDPTQKLGAIDSSEAVEAGILQEEEERETTNKKLPLSQCITIRDFEAVAQQTMRKESWEYYSTGSEDEFTLKENITAFQKIRFRPKVLVNVEHVDISTTLLGTKTAIPIYVSATASAKLGHPEGEVVLTRASNNHGIVQMIPLYSSCPIEEVTDARAPDATQWFQIYVKKDRNAARKAVEKAERLGCKALCITVDNPHLGSRERVLRSHHEGDTGNDDEFEDAPATELDPSLTTNASLAWEDIPWFQSITKMPIVIKGVQRVEDVLTAVKYGVSAVILSNHGGRQLEYAEAPIEVLAEVMPILRERGLDKKIEVYMDGGVRRGTDVLKALCLGARGVGIGRPFLYAMAGYGQKGVEKAMRIFKDELERNMRLIGCNSIDELHPGLVKLLSRDQAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMW2</accession>
    <name>C7ZMW2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_34839</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698959">
        <property type="protein sequence ID" value="EEU34636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040349.1">
        <property type="nucleotide sequence ID" value="XM_003040303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMW2"/>
    <dbReference type="GeneID" id="9678776"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_34839"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_34839"/>
    <dbReference type="eggNOG" id="ENOG502S05E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019364_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZMW2"/>
    <dbReference type="OMA" id="SEGCPHD"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="5">
        <location>
            <begin position="131"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU34636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="387" mass="43207" checksum="E16CB359AA3E8635" modified="2009-10-13" version="1">MAANSPLKALFAYIYVLLYSPWLLSHFGLDVALCLLPWARPSRQWSLNQAARMRVVRLLLLYWSLTKAGDRLNLRPGREKNRFEVVAARSPKLYRGVLADITILPAQLGLTWIPARPPPPELVRSNMMVALHFHGGAFVIGNGRDEDTGYVARYLIEQTGCTHVCTPQYRLSSSDGGRFPAPLQDALTAYLCLIQTKGIPASQIILSGDSAGANIALGLLRYIHEYGQQDDIPFPRAVTLWSPWVDVSAALEQDMTKSPNYKTDYLSKEFGRWGALTISESGMFDPSGPYLSPLRHPFKPDVSIPTFVNAGSNEVLYHDIRDFCERYQKHGWMIHLDISEHCPHDILLLGPRVGFGAEAEKAAEHAKDFLIEAAGINLRSYSRDSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZN33</accession>
    <name>C7ZN33_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_88848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698962">
        <property type="protein sequence ID" value="EEU34564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040277.1">
        <property type="nucleotide sequence ID" value="XM_003040231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZN33"/>
    <dbReference type="GeneID" id="9678698"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88848"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88848"/>
    <dbReference type="eggNOG" id="ENOG502RKN3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1461701_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZN33"/>
    <dbReference type="OrthoDB" id="5106481at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU34564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="185" mass="20641" checksum="099D8EFB6131C193" modified="2009-10-13" version="1">MCRHHPNSICGKSRHFYEEKLNTGRRFRLFICESTQADVAYLLHHHPDRIGAKAMARACGLNFDSSRTGRVLLNKFMQQVMYLEKKMVRAQAAGHQLRFQCAATSPPVLPGVANQTSPQNPVASMTQASFQIPGTPAPAPMFAPTEKTVMPTPNQSVQPMKMLDRHDLDALAEQLGTKIKLENQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNB5</accession>
    <name>C7ZNB5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC-2 type transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_64912</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698965">
        <property type="protein sequence ID" value="EEU34503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040216.1">
        <property type="nucleotide sequence ID" value="XM_003040170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNB5"/>
    <dbReference type="GeneID" id="9678030"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_64912"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_64912"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082755_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZNB5"/>
    <dbReference type="OMA" id="NIFYSHR"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="ABC-2 type transporter transmembrane" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU34503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="167" mass="18406" checksum="D1A7BE852353CCD0" modified="2009-10-13" version="1">MVVAGLPNADIAGAVVNLLFVMMFAFNGVLAGPKQLPGFWVFMYPVNPFTYIVEGFLGMTLASAPVTCADNEILTFHAPKGSTCAEDMSDYINMAGGQLVNSSQYDSECSYCPIADTNAFLASISVDRAHRWRNSGLWWVYIVFNIVATTIFYWLAHVPKNCKINKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPX1</accession>
    <name>C7ZPX1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_55814</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698974">
        <property type="protein sequence ID" value="EEU33944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039657.1">
        <property type="nucleotide sequence ID" value="XM_003039611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZPX1"/>
    <dbReference type="STRING" id="660122.C7ZPX1"/>
    <dbReference type="GeneID" id="9667179"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55814"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55814"/>
    <dbReference type="eggNOG" id="KOG3867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_11_1_1"/>
    <dbReference type="InParanoid" id="C7ZPX1"/>
    <dbReference type="OMA" id="YSDQWAQ"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16025">
        <property type="entry name" value="PAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF33">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="5">
        <location>
            <begin position="7"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU33944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="555" mass="62105" checksum="4011251248919A6A" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQ05</accession>
    <name>C7ZQ05_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_89051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698977">
        <property type="protein sequence ID" value="EEU33901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039614.1">
        <property type="nucleotide sequence ID" value="XM_003039568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQ05"/>
    <dbReference type="GeneID" id="9667137"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89051"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89051"/>
    <dbReference type="HOGENOM" id="CLU_1949383_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZQ05"/>
    <dbReference type="OMA" id="KDGIMSD"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU33901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="129" mass="13758" checksum="3CC8D99DB9F86E74" modified="2009-10-13" version="1">MRLNDEYGTQGIHAWSVQPGAVQTDLARHMPDDGKNVLASDPYPAKVSKNPEQGAATSACGATAAALESMGGKYLENCQIAGPWKPSLGHWGPGRCICQKVDHREVSWRANLFGPGALSGTFQHEQASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQJ8</accession>
    <name>C7ZQJ8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_56209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698998">
        <property type="protein sequence ID" value="EEU33707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039420.1">
        <property type="nucleotide sequence ID" value="XM_003039374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQJ8"/>
    <dbReference type="GeneID" id="9666952"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_56209"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_56209"/>
    <dbReference type="eggNOG" id="ENOG502T0QC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1499807_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZQJ8"/>
    <dbReference type="OrthoDB" id="5101370at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU33707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="180" mass="18611" checksum="6FE9D9A6999897BF" modified="2009-10-13" version="1" fragment="single">MRRESATLAGLLTVAKAQSILIDGVLFAYQTATITECFPMGSGGLEPTPGLSIGGNAPVIHRPAVTGQPIVVEVEAPRCDSCGCDACAHTEVYTFTCDAFCDTGLCKQAYVVTETYSGLTAKPTLAPTDLPFGFTCDVQTCTTCGPEPITATITYPLTERLYINKVPAPTGVPAGSGPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQS0</accession>
    <name>C7ZQS0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_98389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699009">
        <property type="protein sequence ID" value="EEU33634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039347.1">
        <property type="nucleotide sequence ID" value="XM_003039301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQS0"/>
    <dbReference type="STRING" id="660122.C7ZQS0"/>
    <dbReference type="GeneID" id="9666867"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_98389"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98389"/>
    <dbReference type="eggNOG" id="KOG3030">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021458_2_0_1"/>
    <dbReference type="InParanoid" id="C7ZQS0"/>
    <dbReference type="OMA" id="DWIVILV"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF154">
        <property type="entry name" value="PAP2 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G09730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU33634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="413" mass="45890" checksum="42F1B653BF6616F8" modified="2009-10-13" version="1">MVDSGIGNITGSLRRRFSVRLIISYALDWAILIFAAAIGVVFDRIEPAKRPFSPVDPNIAFPYTEHELVPIYLPFILAIGVPAVIVAVVFLIFVPRPTVPNGTPKTLIWHHKLWDSIMVLYKCHKEPLWQAPSRSSEPVLPRLEERKGSYCCQQYAGGYSWGNMNGQLVYASICQQTDSYKLDDGFRSYPSGHASSAAAGLVYASLFLASKFSVTIPFVMPSAAAAAGATGAASHTAFPSHLRPEADPYEPTRARGFDDRSATSSLTTKVSPFGDIGQHNAEIQSLRRQAAAPPIYLLVFTLLPFGVSIFIAGSRWYDMRHHGFDILFGYLMGVITSFYAFYYYHLPIRAGAGWAWGPRSDERAFWAGVGRLGYAGTDEELAEGRPSQNFQDVEQQRMDEADRAENRFRENRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZRI3</accession>
    <name>C7ZRI3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_89544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699090">
        <property type="protein sequence ID" value="EEU33374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039087.1">
        <property type="nucleotide sequence ID" value="XM_003039041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZRI3"/>
    <dbReference type="STRING" id="660122.C7ZRI3"/>
    <dbReference type="GeneID" id="9666611"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89544"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89544"/>
    <dbReference type="eggNOG" id="ENOG502SE29">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_3_0_1"/>
    <dbReference type="InParanoid" id="C7ZRI3"/>
    <dbReference type="OMA" id="WDKSARP"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="34"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="80"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU33374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="253" mass="27372" checksum="7590875F625C58A2" modified="2009-10-13" version="1">MAQISFFRYLRLKLSLYSPSANGTPSLATKKPVVVNWHGSGFMLPSLGSDHDFYARIAKETGFVVLDADYRKGPEVESRHQEFDLERVAISGFSAGANLALVASSCLKDSYPALKIQVTVAIYPPVDLSIDPEAKTVPHPIRPIPAAVARIFDACYIPDDSLRSDPRISPTFADPALFPEAVVILTCSGDTLAPEGNAMATKLQNGKRRVINQTLEGVGHAFDKGVREGTHEWEQRALAYSTSITALKAGLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZRL9</accession>
    <name>C7ZRL9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_89548</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699104">
        <property type="protein sequence ID" value="EEU33335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039048.1">
        <property type="nucleotide sequence ID" value="XM_003039002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZRL9"/>
    <dbReference type="GeneID" id="9667198"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89548"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89548"/>
    <dbReference type="HOGENOM" id="CLU_2264435_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZRL9"/>
    <dbReference type="OrthoDB" id="5041117at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU33335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="103" mass="11544" checksum="64963805CC3181D8" modified="2009-10-13" version="1">MTVEEGRQAIDQMDANAQVVAESSRRSGQGRSARPGVRRCGVCGQPGHNARTCQVVIETSGEEYTHLSVQLTYQFIIKNLDYYAGIEIYNYNNYSNILIKVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7YH75</accession>
    <name>C7YH75_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_74873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054295.1">
        <property type="nucleotide sequence ID" value="XM_003054249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YH75"/>
    <dbReference type="STRING" id="660122.C7YH75"/>
    <dbReference type="GeneID" id="9664451"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74873"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74873"/>
    <dbReference type="eggNOG" id="ENOG502S49J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007263_2_0_1"/>
    <dbReference type="InParanoid" id="C7YH75"/>
    <dbReference type="OMA" id="ADNIPNV"/>
    <dbReference type="OrthoDB" id="5591786at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014839">
        <property type="entry name" value="Crt10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08728">
        <property type="entry name" value="CRT10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU48582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="656" mass="73630" checksum="99E1D047C3A374F8" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHZ2</accession>
    <name>C7YHZ2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transport protein USO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_32130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
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                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
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                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
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                <person name="Zamora J."/>
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                <person name="Salamov A."/>
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            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU48114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="597" mass="66161" checksum="B2E9CEC69D2C4835" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIR5</accession>
    <name>C7YIR5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Short chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_90417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053854.1">
        <property type="nucleotide sequence ID" value="XM_003053808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIR5"/>
    <dbReference type="STRING" id="660122.C7YIR5"/>
    <dbReference type="GeneID" id="9664686"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90417"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90417"/>
    <dbReference type="eggNOG" id="KOG1014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_17_0_1"/>
    <dbReference type="InParanoid" id="C7YIR5"/>
    <dbReference type="OMA" id="WVFEHED"/>
    <dbReference type="OrthoDB" id="5399006at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431:SF7">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU48141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="26424" checksum="9652484D2923CE70" modified="2009-10-13" version="1">MGSFYTIIAGAGPGTGRAAALRFSKTYPVVMLARRPESYEDIVRDIRQAGGQALGIVADVADSASLSRAFDIVGEALPNLKLAAAVYNVNSGFMMKPFLELQLDEFQNSFGKTGDAFFNFTQKTLPLLREAVKDSPHPPTLITTGATASIKASAGFAAFSAGRFAMRALNQSLAREFGPQGVHIAHVVIDGLIDTPASKAWSKTDVPDSKIQPDAIAETYWHLHIQPRSAFTQEMDIRPFSERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJ59</accession>
    <name>C7YJ59_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_90493</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053923.1">
        <property type="nucleotide sequence ID" value="XM_003053877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJ59"/>
    <dbReference type="STRING" id="660122.C7YJ59"/>
    <dbReference type="GeneID" id="9663705"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90493"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90493"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_6_3_1"/>
    <dbReference type="InParanoid" id="C7YJ59"/>
    <dbReference type="OMA" id="LDRPTSW"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000153">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="8">
        <location>
            <begin position="8"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU48210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="424" mass="46417" checksum="6FCDB0B66977A58C" modified="2009-10-13" version="1">MAPTKDFNIAVVGGGIAGLTLAIALHHRGIPVKLYERASKFEEIGAGVSFTPNAVRAMEFCHPGVHEAFEKVCTRNSWPSKQKVWFDFVDGTKDEGAGFTINSSLGQNGVHRAHYLDELAKLFPEDQAVFGKCLDTITESDGKVTMSFTDGTTASADAVIGCDGIKSRVRQLVVGLDHPSAHPTYSYKYAYRGMVPMEKAVEAVGEEKARNATIHMGKGGHVLTFPVDHGRKLNIVAFRTSPTDWEDYSRTTTVASRQDALKDFAGYGSAVTGLLRLTEEQLKVWAIFDLGDHPAPTFHKGRVCIAGDAAHATSPHHGAGAGFCIEDSAFLAELLSSIDSSRDLPSVFETFDECRRERSQWLVQSSRWIGNCYEWLADGIGSDMVKIESEINERNGIIANFDLEGEVAQAKGDLQKRLDHCYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJ85</accession>
    <name>C7YJ85_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_75591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054649.1">
        <property type="nucleotide sequence ID" value="XM_003054603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJ85"/>
    <dbReference type="GeneID" id="9663722"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75591"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75591"/>
    <dbReference type="eggNOG" id="ENOG502RNTY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025796_2_0_1"/>
    <dbReference type="InParanoid" id="C7YJ85"/>
    <dbReference type="OMA" id="PANNCAR"/>
    <dbReference type="OrthoDB" id="10071171at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="531"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU48936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="555" mass="62249" checksum="05C0B92DCFA0E3B3" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLG8</accession>
    <name>C7YLG8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="13">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NECHADRAFT_103669</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 13">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="13"/>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052972.1">
        <property type="nucleotide sequence ID" value="XM_003052926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YLG8"/>
    <dbReference type="STRING" id="660122.C7YLG8"/>
    <dbReference type="GeneID" id="9663663"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_103669"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_103669"/>
    <dbReference type="eggNOG" id="KOG2467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022477_0_1_1"/>
    <dbReference type="InParanoid" id="C7YLG8"/>
    <dbReference type="OMA" id="TQPFFSQ"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF57">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 12 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="14">
        <location>
            <begin position="40"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU47259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="504" mass="55248" checksum="4B5FB58A2290F3E1" modified="2009-10-13" version="1">MINMRALRQTGQCLRGKSSLASRVSTRTFASQTDLLGATLQNGDPEIHAILKREETRQNHFINLIPSENFTSRSVLDALGSVMQNKYSEGYPGARYYGGNEHIDEAERLCQKRALEAFRLDPEQWGVNVQPLSGSPANLYAYSALLNTHERIMGLDLPHGGHLSHGYQLPHKKISMVSKYFETFPYRLNEETGLIDYDKLRDNAILYRPKIIIAGTSAYSRLIDYERMRAIADEVGAYLLSDMAHISGLVAAGVIPSPFDKSDVVTTTTHKSLRGPRGAMIFFRKGVRSTDKKGNKILYDLEGPINASVFPGHQGGPHNHTITALAVALRQAKSPEFAEYQKTVLTNAQALSNQLSSLGYKLVSGGTDNHLVLVDLKSKGVDGARVERVLELVGVASNKNTVPGDRSALKPGGLRLGTPAMTTRGFSAEDFKRVADIVDRGVKITIAVDKDARAAAEAKGAKNPKTVKAFLEYLGDGSSVKEIGELRKEVEEWVGGFPQPWLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLJ9</accession>
    <name>C7YLJ9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_36272</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052506.1">
        <property type="nucleotide sequence ID" value="XM_003052460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YLJ9"/>
    <dbReference type="STRING" id="660122.C7YLJ9"/>
    <dbReference type="GeneID" id="9663759"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_36272"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_36272"/>
    <dbReference type="eggNOG" id="KOG3022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024839_0_2_1"/>
    <dbReference type="InParanoid" id="C7YLJ9"/>
    <dbReference type="OMA" id="CNHESHI"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001278">
        <property type="entry name" value="Iron-sulfur cluster carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961:SF2">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU46793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="302" mass="32802" checksum="9049F2C1C4B7881C" modified="2009-10-13" version="1">MRPTSARLFQTLRALQHENPLGLPRSGTPPNWPRRPQRRNIAGVEKVIAVSSAKGGVGKSTVAANLSLAFARLGYRAGILDTDIFGPSIPTLFDLSGEPRLSSSQFHQNQLIPLTNYGVKTMSMGYLVGENAPVVWRGPMVMKAIQQLLHEVDWGGLDILVLDLPPGTGDTQLTITQQVILDGACSVIVTTPHTLATKDAVKGINMFKTVDVNILGLVQNMSLFQCPHCYGETHIFGSNARVEKLCQEHQIDFLGDIPLHPNIGDDGERGKPTVVAEPTSERANAFLKIAQDICPKINLSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7YM33</accession>
    <name>C7YM33_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_99623</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053096.1">
        <property type="nucleotide sequence ID" value="XM_003053050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YM33"/>
    <dbReference type="STRING" id="660122.C7YM33"/>
    <dbReference type="GeneID" id="9671119"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_99623"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_99623"/>
    <dbReference type="eggNOG" id="KOG0598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_43_1"/>
    <dbReference type="InParanoid" id="C7YM33"/>
    <dbReference type="OMA" id="CEVDWWS"/>
    <dbReference type="OrthoDB" id="354826at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05578">
        <property type="entry name" value="STKc_Yank1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000354">
        <property type="entry name" value="AGC/YANK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000469">
        <property type="entry name" value="Serine/threonine-protein kinase 32B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF30">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 32B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="382"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="486"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="410"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="516"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU47383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="533" mass="59876" checksum="C74A763D76B3D7A5" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C7YMM7</accession>
    <name>C7YMM7_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_92030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053187.1">
        <property type="nucleotide sequence ID" value="XM_003053141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YMM7"/>
    <dbReference type="STRING" id="660122.C7YMM7"/>
    <dbReference type="GeneID" id="9671222"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_92030"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_92030"/>
    <dbReference type="eggNOG" id="KOG0238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_3_3_1"/>
    <dbReference type="InParanoid" id="C7YMM7"/>
    <dbReference type="OMA" id="FINKPKH"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000028">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF33">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="9">
        <location>
            <begin position="43"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="159"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU47474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="708" mass="77699" checksum="BD913458428EBC0D" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNF5</accession>
    <name>C7YNF5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_29157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052824.1">
        <property type="nucleotide sequence ID" value="XM_003052778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNF5"/>
    <dbReference type="STRING" id="660122.C7YNF5"/>
    <dbReference type="GeneID" id="9664397"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_29157"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_29157"/>
    <dbReference type="HOGENOM" id="CLU_1901241_0_0_1"/>
    <dbReference type="InParanoid" id="C7YNF5"/>
    <dbReference type="OMA" id="CEHYLST"/>
    <dbReference type="OrthoDB" id="3862662at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU47111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="134" mass="15296" checksum="831F85D4B851430F" modified="2009-10-13" version="1" fragment="single">RRLKRRCTKDWPSCSLCIRLGKVCDYSNPLSTRATEAAGLYPLFENPSCLFPSSFFMDAHLFAPLNTTNALTRVPTSRLKLITSDHLAIEERGALHEEYFTSMHQWLPIISEKRLLDARLALNDACHDLLLLCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNH9</accession>
    <name>C7YNH9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_99793</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052838.1">
        <property type="nucleotide sequence ID" value="XM_003052792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNH9"/>
    <dbReference type="GeneID" id="9671370"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_99793"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_99793"/>
    <dbReference type="eggNOG" id="ENOG502RS5Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021699_0_0_1"/>
    <dbReference type="InParanoid" id="C7YNH9"/>
    <dbReference type="OMA" id="YFEYAHL"/>
    <dbReference type="OrthoDB" id="4850804at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="669"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="358"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="509"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="534"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU47125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="750" mass="81102" checksum="FFA312408E669BA5" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNY9</accession>
    <name>C7YNY9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_79472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052374.1">
        <property type="nucleotide sequence ID" value="XM_003052328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNY9"/>
    <dbReference type="GeneID" id="9670896"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79472"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79472"/>
    <dbReference type="eggNOG" id="ENOG502SPRZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_368048_0_0_1"/>
    <dbReference type="InParanoid" id="C7YNY9"/>
    <dbReference type="OMA" id="AMANTRY"/>
    <dbReference type="OrthoDB" id="5307331at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="743"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU46661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="757" mass="84944" checksum="8F08AF4F6ACE1359" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>C7YP45</accession>
    <name>C7YP45_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="3 12">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">FUS3</name>
        <name evidence="14" type="ORF">NECHADRAFT_103967</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="12">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="3 12"/>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051945.1">
        <property type="nucleotide sequence ID" value="XM_003051899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YP45"/>
    <dbReference type="FunCoup" id="C7YP45">
        <property type="interactions" value="589"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YP45"/>
    <dbReference type="GeneID" id="9673098"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_103967"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_103967"/>
    <dbReference type="eggNOG" id="KOG0660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="InParanoid" id="C7YP45"/>
    <dbReference type="OMA" id="SFFDFDY"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075018">
        <property type="term" value="P:positive regulation of appressorium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07849">
        <property type="entry name" value="STKc_ERK1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000040">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000073">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="23"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU46232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="355" mass="41249" checksum="7692E9AC7D3FEA7A" modified="2009-10-13" version="1">MSRSNPPNPTGSRKISFNVSEQYDIQDVVGEGAYGVVCSAIHKPSGQKVAIKKITPFDHSMFCLRTLREMKLLRYFNHENIISILDIQKPRNYESFNEVYLIQELMETDMHRVIRTQDLSDDHCQYFIYQTLRALKAMHSANVLHRDLKPSNLLLNANCDLKVCDFGLARSAASQEDNSGFMTEYVATRWYRAPEIMLTFKEYTKAIDVWSVGCILAEMLSGKPLFPGKDYHHQLTLILDVLGTPTMEDYYGIKSRRAREYIRSLPFKKKVPFRTLFPKTSDLALDLLEKLLAFNPVKRITVEEALKHPYLEPYHDPEDEPTAPPIPEEFFDFDKHKDNLSKEQLKQLIYQEIMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>C7YP73</accession>
    <name>C7YP73_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_103979</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051961.1">
        <property type="nucleotide sequence ID" value="XM_003051915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YP73"/>
    <dbReference type="FunCoup" id="C7YP73">
        <property type="interactions" value="764"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YP73"/>
    <dbReference type="GeneID" id="9673114"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_103979"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_103979"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008776_2_0_1"/>
    <dbReference type="InParanoid" id="C7YP73"/>
    <dbReference type="OMA" id="TNVDPGW"/>
    <dbReference type="OrthoDB" id="424572at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Stress response regulator/HFS transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="351"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="309"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="562"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="8">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU46248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="591" mass="64989" checksum="D7AE61F6121E38DE" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPI7</accession>
    <name>C7YPI7_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_78768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051565.1">
        <property type="nucleotide sequence ID" value="XM_003051519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YPI7"/>
    <dbReference type="GeneID" id="9668642"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78768"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78768"/>
    <dbReference type="eggNOG" id="ENOG502RPXA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_719781_0_0_1"/>
    <dbReference type="InParanoid" id="C7YPI7"/>
    <dbReference type="OMA" id="GAINTHV"/>
    <dbReference type="OrthoDB" id="3903267at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU45852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="384" mass="42732" checksum="895379E311AAC9EC" modified="2009-10-13" version="1">MSPPSNIPSSTSQLQRFKSQLNDLVARERAHTQATAAVIPESPIEAFLQKPETPKENNNFMASTRGCSTYPTDQLQMMASQLAEARRNGEFPTTKASPMDVDATIEDYQALTRLRQLRGNPMCPAPEAYNHLRIEITRRIRERDALSGDDETEGAAARRVDTYLQAVQHENRYFAAANKPMPQRRVQTANKGNNGCNGQITKSNANGSDEKMRSMVEQTIEQGIADATGPLRMNVGKLDAQASTLRRQSDTMGQQIEMQQQTVSALQTMIQPQAFNIQATTQNLAMTHGLANQLSQIANDLPQSINQAVNSALQEHTQASLNGLLEAQRQAIHDIEMRTQRLNELNREAEARDSTTRSRTNSTASARDRSKIQSFFQKTFGRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7YT86</accession>
    <name>C7YT86_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_80220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU44990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050703.1">
        <property type="nucleotide sequence ID" value="XM_003050657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YT86"/>
    <dbReference type="GeneID" id="9666478"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_80220"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_80220"/>
    <dbReference type="eggNOG" id="ENOG502S1H2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081622_0_0_1"/>
    <dbReference type="InParanoid" id="C7YT86"/>
    <dbReference type="OMA" id="CINTCVE"/>
    <dbReference type="OrthoDB" id="4778251at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988651" description="Extracellular membrane protein CFEM domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU44990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="30859" checksum="7D8CCF546CB7E1BD" modified="2009-10-13" version="1">MRFSLSTLVALGALQTLGVNAQDSTACITDCVGRLQAPNAAYNCPDNTASCICASTEFAKGMAECARPCGVADTDITGNLASGFCAGLPVVQLPAATSGASTEASSAPATTSEAAASTSEAAATTEAASSSAAPTSSAAPEETTSSAAESVPVSTSAEAESTATEEATSATDSASATTSASASATDKASTTEGAAGAGATSDSSDEDDKEEESSGSGGLSKSAQIGIGIGVTAGVLALLGIALCFLWRRRSQRNNLPRGNTAISHPMPAGGSNYHSADQGSIVEKGGYDLEMMSHRYEDMLPRQKPRTMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C7YTS5</accession>
    <name>C7YTS5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_49453</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050009.1">
        <property type="nucleotide sequence ID" value="XM_003049963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YTS5"/>
    <dbReference type="STRING" id="660122.C7YTS5"/>
    <dbReference type="GeneID" id="9675170"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_49453"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_49453"/>
    <dbReference type="eggNOG" id="KOG0245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_2_3_1"/>
    <dbReference type="InParanoid" id="C7YTS5"/>
    <dbReference type="OMA" id="SFWSHNT"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000050">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="6"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="470"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="402"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="476"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="110"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU44296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="547" mass="62138" checksum="1F4898ADD2FE6806" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7YU17</accession>
    <name>C7YU17_FUSV7</name>
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        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_84771</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050048.1">
        <property type="nucleotide sequence ID" value="XM_003050002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YU17"/>
    <dbReference type="GeneID" id="9665411"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84771"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84771"/>
    <dbReference type="eggNOG" id="ENOG502S8DA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122021_1_1_1"/>
    <dbReference type="InParanoid" id="C7YU17"/>
    <dbReference type="OMA" id="FYMHGDP"/>
    <dbReference type="OrthoDB" id="202672at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024512">
        <property type="entry name" value="Ser_palmitoyltrfase_ssu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11779">
        <property type="entry name" value="SPT_ssu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU44335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="111" mass="12692" checksum="A652DFA936DED29F" modified="2009-10-13" version="1">MAVLGAFRKWLSLKQYQLEVTFSVYMFTPWEKFFFSSIVFLLFSLTFIAACLYLPHHISFLCGRAWYYINGEHIDVAEAMHEVVRDISASALSGTVADVTKEAAETVVREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7YUQ3</accession>
    <name>C7YUQ3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_105372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050164.1">
        <property type="nucleotide sequence ID" value="XM_003050118.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9674949"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_105372"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_105372"/>
    <dbReference type="eggNOG" id="ENOG502QR8W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_247299_0_0_1"/>
    <dbReference type="InParanoid" id="C7YUQ3"/>
    <dbReference type="OMA" id="HIEKHPP"/>
    <dbReference type="OrthoDB" id="3439539at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="716"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="769"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="799"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="873"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="892"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="920"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="933"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="962"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1105"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1166"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1226"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1364"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1404"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1505"/>
            <end position="1514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU44451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1530" mass="162041" checksum="16F74C10D14979D1" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>C7YUS2</accession>
    <name>C7YUS2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein transport protein SEC22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">NECHADRAFT_102841</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050173.1">
        <property type="nucleotide sequence ID" value="XM_003050127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YUS2"/>
    <dbReference type="FunCoup" id="C7YUS2">
        <property type="interactions" value="1045"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YUS2"/>
    <dbReference type="GeneID" id="9674958"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102841"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102841"/>
    <dbReference type="eggNOG" id="KOG0862">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054453_4_0_1"/>
    <dbReference type="InParanoid" id="C7YUS2"/>
    <dbReference type="OMA" id="FIYWRFF"/>
    <dbReference type="OrthoDB" id="1719357at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15866">
        <property type="entry name" value="R-SNARE_SEC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000007">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000014">
        <property type="entry name" value="Transport protein sec22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044565">
        <property type="entry name" value="Sec22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45837">
        <property type="entry name" value="VESICLE-TRAFFICKING PROTEIN SEC22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="16">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="17">
        <location>
            <begin position="134"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEU44460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="215" mass="24708" checksum="1FED454DEC301BA8" modified="2009-10-13" version="1">MIYSTQISRLDGLMLCASVDDEQAEASLAETKQNVRQVLRKLTRNSESQASIETSAHTLHYLIDSDVVFLAICAPSYPRKLAFTYLADLAREFTTTYPAAQVHSPSLRPYAFMEFDTFIAKTKTTYADSRASANLDRLNDELRDVTKVMTKNIEDLLYRGDSLERMGEISSRLRDDSKKYRRAAVRINWELLLKQYGPFAGLGFIILVFLYWRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7YV79</accession>
    <name>C7YV79_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_85181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050651.1">
        <property type="nucleotide sequence ID" value="XM_003050605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YV79"/>
    <dbReference type="GeneID" id="9675032"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85181"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85181"/>
    <dbReference type="eggNOG" id="ENOG502RMIZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_940373_0_0_1"/>
    <dbReference type="InParanoid" id="C7YV79"/>
    <dbReference type="OrthoDB" id="5100673at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU44938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="296" mass="35310" checksum="544EAF28ABAEC1E5" modified="2009-10-13" version="1">MAEYSIPDVMIHRVIPSMFNAGNFPMQWIGDNPTLDERRQYIHDYVKWRLPHDDMEKQERELRDLAERKVAMKLINENVVEIGAEQFEWLIDEMFWHTWLGYLENTPPFPWPCPTQSDELEELSQSFDKWLDIYKREGDLVKVPEQGDSTSSAEQHNASGNETTATTQDLTIAETSNGSDHLQELSEQQDERIERMNKRIQQQGRKISQKDTKIRQRDQEISQKDRRIWVLEELLRVGRDQLQLEQQQNRDLLRLEQCLFRALQQQLNQQTDDLRNQWQLLLQQRSTLPRHDASRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVJ2</accession>
    <name>C7YVJ2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_7995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049718.1">
        <property type="nucleotide sequence ID" value="XM_003049672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVJ2"/>
    <dbReference type="GeneID" id="9677293"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_7995"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_7995"/>
    <dbReference type="eggNOG" id="ENOG502QUBE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047729_3_2_1"/>
    <dbReference type="InParanoid" id="C7YVJ2"/>
    <dbReference type="OMA" id="GMQCTGT"/>
    <dbReference type="OrthoDB" id="5418436at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021476">
        <property type="entry name" value="Egh16-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618:SF4">
        <property type="entry name" value="CAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618">
        <property type="entry name" value="SURFACE PROTEIN MAS1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11327">
        <property type="entry name" value="Egh16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988711" evidence="1">
        <location>
            <begin position="18"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU44005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="206" mass="21021" checksum="63043E6A7A478231" modified="2009-10-13" version="1" fragment="single">KTAITWTLLALAELTAGHSVITNAVGDSGGSGMALGVDNTTPRDGTRRRPFQQDATRFRGDSAETVGETLGGGDNDVEAGTSAILAETNDDLPQVTQGGELTMTLHQVNSDGAGPYTCMINDDGTGQSWTDITVTQNVEGNERGRNRDGEASDFPLVASIPADQGCTGTVAGQNNVCLVRCQNPARAGPFGGVVPVQMAGGNAGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVU5</accession>
    <name>C7YVU5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mitochondrial ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_29824</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU43850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049563.1">
        <property type="nucleotide sequence ID" value="XM_003049517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVU5"/>
    <dbReference type="FunCoup" id="C7YVU5">
        <property type="interactions" value="109"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YVU5"/>
    <dbReference type="GeneID" id="9677350"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_29824"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_29824"/>
    <dbReference type="eggNOG" id="KOG0899">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144911_1_2_1"/>
    <dbReference type="InParanoid" id="C7YVU5"/>
    <dbReference type="OMA" id="EYVAFEV"/>
    <dbReference type="OrthoDB" id="2043at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF8">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU43850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="9356" checksum="1449C9133039BAB2" modified="2009-10-13" version="1">MYATRVLLKRSVWKGESIAFFSLPIVWPKSVGDKVPPVRTQARSATILPNFVGLKFEVHNGKDYHEVTITEDMVGHKLGEFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVX2</accession>
    <name>C7YVX2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_98518</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU43862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049575.1">
        <property type="nucleotide sequence ID" value="XM_003049529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVX2"/>
    <dbReference type="GeneID" id="9677150"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_98518"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98518"/>
    <dbReference type="eggNOG" id="ENOG502RYZ7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007073_0_0_1"/>
    <dbReference type="InParanoid" id="C7YVX2"/>
    <dbReference type="OMA" id="CTKNGHQ"/>
    <dbReference type="OrthoDB" id="2354469at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
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            <end position="64"/>
        </location>
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            <begin position="1"/>
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        </location>
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            <end position="242"/>
        </location>
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            <end position="426"/>
        </location>
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            <end position="672"/>
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            <end position="98"/>
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            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
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            <begin position="219"/>
            <end position="233"/>
        </location>
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        <location>
            <begin position="638"/>
            <end position="650"/>
        </location>
    </feature>
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            <end position="838"/>
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    </feature>
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        <location>
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            <end position="856"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7YW28</accession>
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        </submittedName>
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        <name evidence="4" type="ORF">NECHADRAFT_74161</name>
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        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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            <taxon>Fusarium vanettenii</taxon>
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        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="9677183"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="23"/>
        </location>
    </feature>
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        <location>
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            <end position="1514"/>
        </location>
    </feature>
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            <end position="846"/>
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    </feature>
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            <end position="886"/>
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        </location>
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        </location>
    </feature>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEU44100.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1514" mass="172211" checksum="0D14D77B01B286DD" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7YW57</accession>
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        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 27</fullName>
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    </protein>
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            <taxon>Hypocreales</taxon>
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        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
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                <person name="Salamov A."/>
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                <person name="Lindquist E."/>
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                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="23">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
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    </reference>
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        <subcellularLocation>
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        <subcellularLocation>
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        <subcellularLocation>
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        <subcellularLocation>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0006914">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATG27"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
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    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002987655" description="Autophagy-related protein 27" evidence="20">
        <location>
            <begin position="21"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="21">
        <location>
            <begin position="24"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="181"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EEU43909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="347" mass="38423" checksum="F4C67615E4DA1DF3" modified="2009-10-13" version="1">MHRPELFSFLLPLLATSVYGAENLDCSNIRVDGQKFDLSKLKGAHSVVTTLLEPSTMEHHNTTYTLDVCGPLEKKGANKCPNGTRVCAITHLLGNDTKGESDTIIKVAAIAGNLENAGGSRFDVTPTRLKTSDSNSDRQKEGLRLVLSGGKYPLKGKAPPKEITDQKAIIEFLCDPDKEGTEGEWVWGEGSGKLKARDDEKKEGDDKEKEGDKDGDKDGEESTIEHQLKHDNATLIWDSYGREKDVDVLRLTWYTKYACESQSEGGDGDSSAHWGFFTWFIVIAFLGIAGYLIFASWINFTRYGARGWDLLPHSDTIRDIPYLLKDWIRRVLNTVQGTGSRGGYSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWP3</accession>
    <name>C7YWP3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Nucleolar GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_74372</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU43992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049705.1">
        <property type="nucleotide sequence ID" value="XM_003049659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWP3"/>
    <dbReference type="FunCoup" id="C7YWP3">
        <property type="interactions" value="840"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YWP3"/>
    <dbReference type="GeneID" id="9674543"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74372"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74372"/>
    <dbReference type="eggNOG" id="KOG2423">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011106_4_0_1"/>
    <dbReference type="InParanoid" id="C7YWP3"/>
    <dbReference type="OMA" id="RTQGFNH"/>
    <dbReference type="OrthoDB" id="444945at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000200">
        <property type="term" value="P:regulation of ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01858">
        <property type="entry name" value="NGP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000559">
        <property type="entry name" value="Nuclear/nucleolar GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024929">
        <property type="entry name" value="GNL2_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012971">
        <property type="entry name" value="NOG2_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF9">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08153">
        <property type="entry name" value="NGP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="222"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="473"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="481"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="563"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="583"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="608"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU43992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="624" mass="69631" checksum="10AB2FE215C89170" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYE9</accession>
    <name>C7YYE9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">40S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_105006</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048888.1">
        <property type="nucleotide sequence ID" value="XM_003048842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYE9"/>
    <dbReference type="FunCoup" id="C7YYE9">
        <property type="interactions" value="1075"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YYE9"/>
    <dbReference type="GeneID" id="9665480"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_105006"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_105006"/>
    <dbReference type="eggNOG" id="KOG0187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112958_0_1_1"/>
    <dbReference type="InParanoid" id="C7YYE9"/>
    <dbReference type="OMA" id="MKRIQQG"/>
    <dbReference type="OrthoDB" id="1727351at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.60.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="entry name" value="Ribosomal protein S17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00511">
        <property type="entry name" value="Ribosomal_eS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_eS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018273">
        <property type="entry name" value="Ribosomal_eS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="Ribosomal_eS17_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002242">
        <property type="entry name" value="PRK01151.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="Rps17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00712">
        <property type="entry name" value="RIBOSOMAL_S17E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU43175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="17183" checksum="EA99DA75E8454F22" modified="2009-10-13" version="1">MGRVRTKTVKKSAKVIIERYYPKLTLDFETNKRICDEIAIIASKRLRNKIAGYTTHLMKRIQRGPVRGISFKLQEEERERKDQYVPEVSALDFTQNSESGGQLDVDGETKDLLKHLGFESIPVNVIPVSQQQVPERGGRRYGDRPPRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYL4</accession>
    <name>C7YYL4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_102771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048922.1">
        <property type="nucleotide sequence ID" value="XM_003048876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYL4"/>
    <dbReference type="GeneID" id="9665511"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102771"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102771"/>
    <dbReference type="eggNOG" id="ENOG502T1Y8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123978_0_0_1"/>
    <dbReference type="InParanoid" id="C7YYL4"/>
    <dbReference type="OMA" id="EPVQHPE"/>
    <dbReference type="OrthoDB" id="5282002at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU43209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="148" mass="16386" checksum="22C81798EC374F90" modified="2009-10-13" version="1">MISASRPGTTSDSGLPAPEVREEITACLSDLVSALEAHPSWTPPSPPRGLFHVWDFVCRSRYIMTELDNIYAGRPTKHPEQIPKHDRATSGPQAAALSFHDVLTRTITIDEMIHNPRMLVMLGLSNIDFGDNVRDKSRALKEALAKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYP4</accession>
    <name>C7YYP4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_71064</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048751.1">
        <property type="nucleotide sequence ID" value="XM_003048705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYP4"/>
    <dbReference type="STRING" id="660122.C7YYP4"/>
    <dbReference type="GeneID" id="9665523"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_71064"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_71064"/>
    <dbReference type="eggNOG" id="KOG2033">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008451_0_0_1"/>
    <dbReference type="InParanoid" id="C7YYP4"/>
    <dbReference type="OMA" id="PQSLKSW"/>
    <dbReference type="OrthoDB" id="46189at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033370">
        <property type="entry name" value="COG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="684"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="696"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="715"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU43038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="805" mass="90637" checksum="1E9DBEC3E1B46B2F" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYQ3</accession>
    <name>C7YYQ3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_102773</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048754.1">
        <property type="nucleotide sequence ID" value="XM_003048708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYQ3"/>
    <dbReference type="FunCoup" id="C7YYQ3">
        <property type="interactions" value="922"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YYQ3"/>
    <dbReference type="GeneID" id="9665943"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102773"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102773"/>
    <dbReference type="eggNOG" id="KOG3479">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141397_3_0_1"/>
    <dbReference type="InParanoid" id="C7YYQ3"/>
    <dbReference type="OMA" id="QDFLRMY"/>
    <dbReference type="OrthoDB" id="1551503at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050673">
        <property type="entry name" value="Mito_inner_translocase_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13172">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="13">
        <location>
            <begin position="14"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU43041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="87" mass="10067" checksum="6760D2AEE6C722C9" modified="2009-10-13" version="1">MDMLTAAEQRTLEQRMQKRQVKEFMGAFGGLVEHCFMSCVDDFTSKAISSRESGCINRCVQKWMASQQRISDRFQEHNAQLTAQMNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZT9</accession>
    <name>C7YZT9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_47380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048380.1">
        <property type="nucleotide sequence ID" value="XM_003048334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZT9"/>
    <dbReference type="GeneID" id="9667646"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_47380"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_47380"/>
    <dbReference type="eggNOG" id="ENOG502SPME">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133309_0_0_1"/>
    <dbReference type="InParanoid" id="C7YZT9"/>
    <dbReference type="OMA" id="PFYWDVA"/>
    <dbReference type="OrthoDB" id="4158114at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU42667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="147" mass="16613" checksum="A4230B786A275805" modified="2009-10-13" version="1">MSTQHTARSILESFYAAERIYMSAPPEKRDFAGMAATLSPDVNLEQSSGLPYAGTFKGPQGFLDWAKSMADHFDIVDVQNPEIFEREGSERIVSLGNLHLRVRKTGEDLYFPLCQVIKVDLEAGVITSIQPFYWDVYELNRAIGHRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZZ7</accession>
    <name>C7YZZ7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cation-transporting P-type ATPase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_71444</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048412.1">
        <property type="nucleotide sequence ID" value="XM_003048366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZZ7"/>
    <dbReference type="GeneID" id="9667672"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_71444"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_71444"/>
    <dbReference type="eggNOG" id="KOG0203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_4_1_1"/>
    <dbReference type="InParanoid" id="C7YZZ7"/>
    <dbReference type="OMA" id="MFFLYMW"/>
    <dbReference type="OrthoDB" id="158672at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF21">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="857"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="885"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="936"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="996"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1033"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1061"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="11">
        <location>
            <begin position="115"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="714"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="714"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU42699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1102" mass="122253" checksum="032A76EFF2D89062" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0B0</accession>
    <name>C7Z0B0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_79827</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047886.1">
        <property type="nucleotide sequence ID" value="XM_003047840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0B0"/>
    <dbReference type="GeneID" id="9667233"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79827"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79827"/>
    <dbReference type="eggNOG" id="KOG1237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004790_4_3_1"/>
    <dbReference type="InParanoid" id="C7Z0B0"/>
    <dbReference type="OMA" id="LSECFCN"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="479"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="515"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="576"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="585"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU42173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="600" mass="66005" checksum="C18EBC4D8C0F82CC" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0M9</accession>
    <name>C7Z0M9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Saccharopine dehydrogenase [NAD(+), L-lysine-forming]</fullName>
            <shortName evidence="13">SDH</shortName>
            <ecNumber evidence="4 13">1.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 13">Lysine--2-oxoglutarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">NECHADRAFT_93245</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>L-saccharopine + NAD(+) + H2O = L-lysine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="EC" id="1.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.7" evidence="4 13"/>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047943.1">
        <property type="nucleotide sequence ID" value="XM_003047897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0M9"/>
    <dbReference type="FunCoup" id="C7Z0M9">
        <property type="interactions" value="214"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z0M9"/>
    <dbReference type="GeneID" id="9671928"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_93245"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_93245"/>
    <dbReference type="eggNOG" id="KOG0172">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063085_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z0M9"/>
    <dbReference type="OMA" id="YFFFSHT"/>
    <dbReference type="OrthoDB" id="265306at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004754">
        <property type="term" value="F:saccharopine dehydrogenase (NAD+, L-lysine-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12188">
        <property type="entry name" value="SDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000217">
        <property type="entry name" value="Saccharopine dehydrogenase [NAD(+), L-lysine-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027281">
        <property type="entry name" value="Lys1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF23">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE [NAD(+), L-LYSINE-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018250">
        <property type="entry name" value="Saccharopine_DH_Lys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 13" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 13 14" id="KW-0520">NAD</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="16">
        <location>
            <begin position="8"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="15">
        <location>
            <begin position="178"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="206"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="325"/>
            <end position="328"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR018250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEU42230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="383" mass="42210" checksum="29BE88AAF81D2CDA" modified="2009-10-13" version="1">MSNYPAILLRAEEKPLEHRSFSPAVIKTLVDAGYPITVERSSTDPNFKRIFEDSEYEAAGASLIPAGSWPTAPAGTLILGLKEIPEEDFPLKNDHINQGGWDKVLSRFPRGGSVLYDLEFLVDSEGRRVSAFGFHAGFTGAALGLKSLSWQLAHPGEKLPSVGTFTDGRGYYLNEEELVNQIREDLASAEKALGRKPTAMVLGALGRCGRGAVDLFLKAGIPEENITRWDIQETQAREGPYEEIAQHDIFLNAIYLSKPIPPFVNDDLLSQPGRKLSVVIDVSCDTTNPHNPIPIYSINTTFDDPTVPVTVKDDQNTAPLSVISIDHLPSMLPREASEAFSEGLKESLLTLNERKTSRVWADAEKLFNEKVALLPEELRTKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0P1</accession>
    <name>C7Z0P1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PQ loop repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_40306</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003048083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0P1"/>
    <dbReference type="GeneID" id="9667301"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_40306"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_40306"/>
    <dbReference type="eggNOG" id="KOG2913">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040201_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z0P1"/>
    <dbReference type="OMA" id="DIWKHRT"/>
    <dbReference type="OrthoDB" id="407617at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU42416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="26225" checksum="FB01CABA4E6BB732" modified="2009-10-13" version="1">MDVPVAANVLGTLGALIPQIVVNYRRHNATGLQPSMMMLWAWAGVPLGVYNIVKEYNIALRIQPQILTFLSLVTWIQCYYYERKWSVYRSLLVVLPIAAVMGGIQAGLIIALRIPESKDIEWPMILMASLSAALLAAGPELDYLGIVIYATEFVLWCGVFAAGGYYNFLPWIKKRWSTRESKRVVGQEFQSSGGSREGDNGITLHENPSSSSVFRTASGNSGLRARNAQGRDPQDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0T7</accession>
    <name>C7Z0T7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SNF7 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_40042</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048152.1">
        <property type="nucleotide sequence ID" value="XM_003048106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0T7"/>
    <dbReference type="FunCoup" id="C7Z0T7">
        <property type="interactions" value="520"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z0T7"/>
    <dbReference type="GeneID" id="9671957"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_40042"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_40042"/>
    <dbReference type="eggNOG" id="KOG2910">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086201_0_1_1"/>
    <dbReference type="InParanoid" id="C7Z0T7"/>
    <dbReference type="OMA" id="RAKQPAM"/>
    <dbReference type="OrthoDB" id="441172at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF5">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="168"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU42439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="22288" checksum="4674A9D04BE35AFB" modified="2009-10-13" version="1">MGGNASKVTAQDKAILDMKNQRDKLHQYQRRISVLTDKETEVARQMLAKGDKKRALLALRRKKYQESLLAKTDAQLAQLEKLTTDVEFALIQKDVLFGLQQGTKVLQEIHAEMGGIEHVEKLMGETADAIAYQQEVSDMLGGRISNQDEEEVEEELLALEAEVAQELPSVPIAQPPVAEQRQEQEAQAERRKQPAMLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1C5</accession>
    <name>C7Z1C5_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SWI/SNF complex protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CHC2101</name>
        <name evidence="3" type="ORF">NECHADRAFT_39896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048052.1">
        <property type="nucleotide sequence ID" value="XM_003048006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1C5"/>
    <dbReference type="FunCoup" id="C7Z1C5">
        <property type="interactions" value="852"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z1C5"/>
    <dbReference type="GeneID" id="9667224"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_39896"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_39896"/>
    <dbReference type="eggNOG" id="KOG2570">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023529_2_0_1"/>
    <dbReference type="InParanoid" id="C7Z1C5"/>
    <dbReference type="OMA" id="NFRCNEP"/>
    <dbReference type="OrthoDB" id="10263741at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd10568">
        <property type="entry name" value="SWIB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="278"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU42339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="503" mass="57219" checksum="E25696598CC158DF" modified="2009-10-13" version="1">MQPQYRAYAQQVPQRSPHATNQRRGGIGPMMSSGPHPSVPLTQAQIAQQQQAQAHASELAKRRSRKPTDKNMPEGVEDSIIDPTGVQRYKELRGVERRLDATITRKRLDIVDYTSRGSKRCKTLRVWISNTVEDQIWQSNGLNVDSFDFTPNMEASFRVKIEGRLLDDETTEDGQAEAEAETSAEDKTEKEGTDSATQKAKAQQKPRFSHFFKSLTVDFDRSQFRNGAEQTVEWKKPDAPPRNQPAASLPAAADFDELTFKRNGDENMNITINLFRQETPERYQLSPELAEVVDMKEATQQEAVMGLWEYIKLLGLQEDEEKRNFRCDEPLKKIVRQGDIGHIPMLNDYVTQHLRPLEPIRLPYTIRVDQDFHKDPQPTIYDIQVPVEDPLRDSLLPLLNNPQYVTMLKEVTGLDDQLARVVQAVAVSKAKHTFFKSLSEDPANFVKNWLSSQKRDLEVIMGEAPRGGGEHASGDEWRKGGKDSVWATQNARESVNVLLSKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1V4</accession>
    <name>C7Z1V4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HypA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_51051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU42065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047778.1">
        <property type="nucleotide sequence ID" value="XM_003047732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1V4"/>
    <dbReference type="GeneID" id="9671739"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51051"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51051"/>
    <dbReference type="eggNOG" id="ENOG502S69W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019145_2_1_1"/>
    <dbReference type="InParanoid" id="C7Z1V4"/>
    <dbReference type="OMA" id="KFDFFYI"/>
    <dbReference type="OrthoDB" id="10004862at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="55961" checksum="EA1987070F1F7E71" modified="2009-10-13" version="1">MTTPYRIHIAPNSTGLWNIKQSEEAAKTATETLQKDLENHHVFLNNVGFHDHMPHHLLALYGTGASVADIQKAHDLRHPLQRPVVSQHQDAVKDLITHWDHDSEYLGKEEYYLDFLAYFQRVIERDGYESVVKSHLLKGDDSANDILLRLHAGVVHPLIQLMYGLEWKQPAIAAQAFAQTCVHNVEGLDQLLLASEQQANTIPRSTKMPSLLSMYEKVKADPQLAGSVRMEDESKIEDGIIQRAREPMIAILEQVHVEPEELDERIAEMFHAMILVASSAAIHPPHHVKYDFFFMHHVNSALMYLTINSQPWLSTADKVRLLEWKIRLDLVQYAARGCPAISLESIESYVPKQPSEESVREIGKRLYDFGDDGHAIKQARATAICHELMVEYKDKSWEVLKDESTWKKIQHMVVDGVEGPSVLYVRSTGFDEAWKVNTPMGFNRIYADSNSRTFLAKTRRRDLLTFCALCRLEVAAHQKLSNHILSNFTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z2L4</accession>
    <name>C7Z2L4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_73005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047398.1">
        <property type="nucleotide sequence ID" value="XM_003047352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z2L4"/>
    <dbReference type="GeneID" id="9676389"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_73005"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_73005"/>
    <dbReference type="eggNOG" id="ENOG502RFFW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011640_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z2L4"/>
    <dbReference type="OMA" id="CTACYLD"/>
    <dbReference type="OrthoDB" id="5324692at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU41685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="65330" checksum="3E30583A52C1645C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z3A3</accession>
    <name>C7Z3A3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_87879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047513.1">
        <property type="nucleotide sequence ID" value="XM_003047467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z3A3"/>
    <dbReference type="GeneID" id="9675945"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87879"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87879"/>
    <dbReference type="eggNOG" id="ENOG502RNQE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_167710_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z3A3"/>
    <dbReference type="OMA" id="GFKVGQE"/>
    <dbReference type="OrthoDB" id="4132874at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU41800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="113" mass="11747" checksum="49046EA65F202343" modified="2009-10-13" version="1">MSGTAPSDPSPGSHARGVEQTPSDANQHGQAQNIIDETKDTYGPTTVDASIGYMIDAGDGDAGLSNRLGNMSNQPKVKGGSAGTERKPATLDKRGFKVGEKADLHDLAQQKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z3E2</accession>
    <name>C7Z3E2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">NECHADRAFT_53983</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047532.1">
        <property type="nucleotide sequence ID" value="XM_003047486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z3E2"/>
    <dbReference type="STRING" id="660122.C7Z3E2"/>
    <dbReference type="GeneID" id="9676345"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_53983"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_53983"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_421501_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z3E2"/>
    <dbReference type="OMA" id="SQNDKRN"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF397">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6 12" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Chitin-binding type-1" evidence="14">
        <location>
            <begin position="54"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="15">
        <location>
            <begin position="115"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="97"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEU41819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="570" mass="63000" checksum="6426135F78DBD897" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z424</accession>
    <name>C7Z424_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="17">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">NECHADRAFT_70869</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 17">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 17">Membrane</location>
            <topology evidence="1 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="17"/>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046956.1">
        <property type="nucleotide sequence ID" value="XM_003046910.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="C7Z424">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z424"/>
    <dbReference type="GeneID" id="9675292"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_70869"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_70869"/>
    <dbReference type="eggNOG" id="KOG0206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000846_5_2_1"/>
    <dbReference type="InParanoid" id="C7Z424"/>
    <dbReference type="OMA" id="GWFLWNI"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000090">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000172">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF174">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="520"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="568"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1289"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1339"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1370"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1401"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1446"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="20">
        <location>
            <begin position="218"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="19">
        <location>
            <begin position="355"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="21">
        <location>
            <begin position="1225"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="672"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="884"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="939"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1495"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="679"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="708"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="884"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="900"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1505"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1530"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="14">
        <location>
            <position position="633"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="633"/>
        </location>
        <ligand>
            <name>ATP</name>
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    <evidence type="ECO:0000256" key="17">
        <source>
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    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
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    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
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    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
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        <source>
            <dbReference type="EMBL" id="EEU41243.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
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    </evidence>
    <sequence length="1542" mass="175580" checksum="207D017871D70E8C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z5H9</accession>
    <name>C7Z5H9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial</fullName>
            <ecNumber evidence="15">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">NECHADRAFT_66841</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Complex I is composed of about 40 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion inner membrane</location>
            <topology evidence="15">Peripheral membrane protein</topology>
            <orientation evidence="15">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="15"/>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU41104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046817.1">
        <property type="nucleotide sequence ID" value="XM_003046771.1"/>
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    <dbReference type="AlphaFoldDB" id="C7Z5H9"/>
    <dbReference type="STRING" id="660122.C7Z5H9"/>
    <dbReference type="GeneID" id="9678622"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_66841"/>
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    <dbReference type="eggNOG" id="KOG2658">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014881_0_1_1"/>
    <dbReference type="InParanoid" id="C7Z5H9"/>
    <dbReference type="OMA" id="QGDGKPH"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="entry name" value="Mitochondrial NADH dehydrogenase flavoprotein 1"/>
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        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
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        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
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        <property type="entry name" value="Nuo51_FMN-bd"/>
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        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
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    <dbReference type="InterPro" id="IPR054765">
        <property type="entry name" value="SLBB_dom"/>
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        <property type="entry name" value="nuoF_fam"/>
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    </dbReference>
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        <property type="entry name" value="PRK13596.1"/>
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    <dbReference type="PANTHER" id="PTHR11780:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1"/>
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    </dbReference>
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    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
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        <property type="entry name" value="SLBB_2"/>
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    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="Nqo1 FMN-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142984">
        <property type="entry name" value="Nqo1 middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="Nqo1C-terminal domain-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 15" id="KW-0288">FMN</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="11 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 15" id="KW-0520">NAD</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding" evidence="17">
        <location>
            <begin position="369"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEU41104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="486" mass="53210" checksum="253379F2344A5A90" modified="2009-10-13" version="1">MLSTRAAPNKAVGLSRTAVRGLATVQDGAPKRTYGGLRDQDRIFQNLYGRYPVDLKSAKRMGDWHKTKEIILKGHDWIIGEVKASGLRGRGGAGFPSGLKWSFMNFKDWDKDTKPRYLVVNADEGEPGTCKDREIMRKDPHKLVEGCLIAGRAMNATAAYIYIRGEFVEEAAVLQRAINEAYADGLIGKNACGSGYDFDVYVHRGAGAYVCGEETSLIESLEGKPGKPRLKPPFPAAVGLFGCPSTVTNVETVAVAPTICRRGGNWFAGFGRERNQGTKLFCISGHVNNPVTVEEEMSIPLRELIDKHCGGVRGGWDNLLAVIPGGSSTPVLPKHVCDDQLMDFDALKDSQSGLGTAAVIVMDKSTDIVRAISRLSHFYRHESCGQCTPCREGSKWTEQIMSRFEKGQAREREIDMLQELTKQVEGHTICALGEAFAWPIQGLIRHFRPELEARMQKFAQESGGAPLAGGWSHDSRAQGKLVSPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z5I6</accession>
    <name>C7Z5I6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_33112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S58 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046238.1">
        <property type="nucleotide sequence ID" value="XM_003046192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z5I6"/>
    <dbReference type="MEROPS" id="P01.003"/>
    <dbReference type="GeneID" id="9678627"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_33112"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_33112"/>
    <dbReference type="eggNOG" id="ENOG502QRNQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024709_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z5I6"/>
    <dbReference type="OMA" id="QANHGQR"/>
    <dbReference type="OrthoDB" id="2107894at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.70.12:FF:000004">
        <property type="entry name" value="Beta-peptidyl aminopeptidase BapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.70.12">
        <property type="entry name" value="L-amino peptidase D-ALA esterase/amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005321">
        <property type="entry name" value="Peptidase_S58_DmpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36512:SF3">
        <property type="entry name" value="BLR5678 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36512">
        <property type="entry name" value="D-AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03576">
        <property type="entry name" value="Peptidase_S58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="DmpA/ArgJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU40525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="395" mass="42055" checksum="7E937FB45B08BF46" modified="2009-10-13" version="1">MSTSTSSGRARLRDILPQLQLGKWPTGELNSITDVPGVLVHTQSIRPDADVNTGVTTILPRPDWSKYSSHAGIFRFNGCGELTGSHWIEETGLLTSPIVLTTTSAIGDGHRGILEYAFRYHTNDEGEMGLFIFPVVAETFDGFLSDQSRFAVTPEHIVTGILNASSERVPEGNTGGGTGMICHRFKGGTGSSSRIVQGFDAVGDPKAYTVGVLVQANYGSQENLHIGGVPIGRIIKSKKASGAVSLENITVKEARKDGSIIVVIATDVPLLPIQLQRVAKRATVGLAKVGGYGNNTSGDIFLAFSTASKIPFQEVSMAPGTSLVKDPYRPRPSAIEMLDDDSINGVFEAAADATEEAIYNALCMAESTAGFKGRSVEALDLDMVKDIVGRRLDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z5W7</accession>
    <name>C7Z5W7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfite oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_66028</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045738.1">
        <property type="nucleotide sequence ID" value="XM_003045692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z5W7"/>
    <dbReference type="STRING" id="660122.C7Z5W7"/>
    <dbReference type="GeneID" id="9678412"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_66028"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_66028"/>
    <dbReference type="eggNOG" id="KOG0535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030575_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z5W7"/>
    <dbReference type="OMA" id="CHRISVY"/>
    <dbReference type="OrthoDB" id="10051395at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02110">
        <property type="entry name" value="SO_family_Moco_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.420.10:FF:000002">
        <property type="entry name" value="sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF6">
        <property type="entry name" value="SULFITE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase molybdopterin-binding" evidence="5">
        <location>
            <begin position="177"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Moybdenum cofactor oxidoreductase dimerisation" evidence="6">
        <location>
            <begin position="384"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU40025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="560" mass="64084" checksum="4EB46F753E38054F" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z5Y9</accession>
    <name>C7Z5Y9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-serine dehydratase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_32611</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DSD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045748.1">
        <property type="nucleotide sequence ID" value="XM_003045702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z5Y9"/>
    <dbReference type="STRING" id="660122.C7Z5Y9"/>
    <dbReference type="GeneID" id="9678424"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_32611"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_32611"/>
    <dbReference type="eggNOG" id="ENOG502QRDB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031639_2_0_1"/>
    <dbReference type="InParanoid" id="C7Z5Y9"/>
    <dbReference type="OMA" id="EPAFRLW"/>
    <dbReference type="OrthoDB" id="20198at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036088">
        <property type="term" value="P:D-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06819">
        <property type="entry name" value="PLPDE_III_LS_D-TA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.20">
        <property type="entry name" value="D-serine dehydratase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051466">
        <property type="entry name" value="D-amino_acid_metab_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026956">
        <property type="entry name" value="D-ser_dehydrat-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042208">
        <property type="entry name" value="D-ser_dehydrat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004:SF2">
        <property type="entry name" value="D-SERINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004">
        <property type="entry name" value="ZGC:162816-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14031">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01119">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-serine dehydratase-like" evidence="3">
        <location>
            <begin position="239"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU40035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="343" mass="37332" checksum="8AD115293426ED9A" modified="2009-10-13" version="1">MEANIKKLFDSLLPTGLNIRPHLKTTKSAILARKLVAAGAKGCCVAKVSEAEAITAAGFDDILITCEIIGPVKVKRLVELFRKHKTIRIVVDSEVGASAINDALEKSGITEPISVLVDLDVGLRRTGVAAGQPAVALAKHISSLKHLRLIGIQGYEGHLQHLHSREDRKKQCLESMKTLTDTADLLRKEGFNIDVVTTGGTGTAEFCATVPGVTELQPGSFIFMDTDYRNAVGTFYSNSLTLLSTVVSKQGDRQVTIDTGLKSLTTDSGLAECKDPRYKHQNLGDEHGSLSWEEGTPALDVGDRVEMIPSHIDPTINLHDFYYAYRKGVIEEIWPVDSRGKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6E8</accession>
    <name>C7Z6E8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_76077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046393.1">
        <property type="nucleotide sequence ID" value="XM_003046347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6E8"/>
    <dbReference type="STRING" id="660122.C7Z6E8"/>
    <dbReference type="GeneID" id="9667953"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76077"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76077"/>
    <dbReference type="eggNOG" id="KOG4350">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057752_3_0_1"/>
    <dbReference type="InParanoid" id="C7Z6E8"/>
    <dbReference type="OMA" id="YMLEPRG"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="35"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU40680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="284" mass="32030" checksum="2B7D21DD5122D1D4" modified="2009-10-13" version="1">MAPPTWETEKLPTDSLCATSNCASLDSLLSSGDYSDMTIRCQGREFKTHRAIVCSQSSFFKKALGSNFKEGDSGIVDLPEDDPNTVQSFLEFLYTGTYSVGGFDRDTVLEAVEVTNEQTLKRLNCAPGSSDYTSGTPRQQESAGGLRWSPYAFKGSVVPAEKSKKQKRRWAMKQSVWVYVLADKYDVPALRLLARDRFFQTGKEMLNLKLWRTASWDETAFFSEIVQTIYDKTSEQDPLRQALHMIVGMKTEDDVLKKRMREEMTLNGELAVGVVDYLTEAKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6W2</accession>
    <name>C7Z6W2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">H/ACA ribonucleoprotein complex non-core subunit NAF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Nuclear assembly factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_90849</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046479.1">
        <property type="nucleotide sequence ID" value="XM_003046433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6W2"/>
    <dbReference type="STRING" id="660122.C7Z6W2"/>
    <dbReference type="GeneID" id="9668820"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90849"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90849"/>
    <dbReference type="eggNOG" id="KOG2236">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012648_2_0_1"/>
    <dbReference type="InParanoid" id="C7Z6W2"/>
    <dbReference type="OMA" id="EWDQDRR"/>
    <dbReference type="OrthoDB" id="21550at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000002">
        <property type="entry name" value="H/ACA ribonucleoprotein complex non-core subunit NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040309">
        <property type="entry name" value="Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633">
        <property type="entry name" value="H/ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633:SF1">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="303"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="536"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="315"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="416"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="442"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="536"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU40766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="577" mass="61336" checksum="424D5A4B52F13C4A" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z700</accession>
    <name>C7Z700_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial inner membrane protease subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_34377</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S26 family. IMP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045930.1">
        <property type="nucleotide sequence ID" value="XM_003045884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z700"/>
    <dbReference type="FunCoup" id="C7Z700">
        <property type="interactions" value="372"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z700"/>
    <dbReference type="GeneID" id="9668839"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_34377"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_34377"/>
    <dbReference type="eggNOG" id="KOG1568">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028723_4_1_1"/>
    <dbReference type="InParanoid" id="C7Z700"/>
    <dbReference type="OMA" id="WIPVIAW"/>
    <dbReference type="OrthoDB" id="9996127at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037730">
        <property type="entry name" value="IMP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041:SF2">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="active site" evidence="11">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU40217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="179" mass="20111" checksum="C1CEF7CF2B7DF0AB" modified="2009-10-13" version="1">MAFGSAWARFRGGGVVGSTTWRLFGFATWIPVIAMFNLHVAELTVVDGASMYPLINDDKDSTLRRDVILNWKWSPHEGIERGMVVTLRSPLHPEVIAVKRVVALENDVVRTKAPHPLPTVRVPQGHVWVEGDGPPGSSLDSNTYGPVSKQLLTGRVTHIVYPFRKFGPIRWWEHERPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z730</accession>
    <name>C7Z730_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_76290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046512.1">
        <property type="nucleotide sequence ID" value="XM_003046466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z730"/>
    <dbReference type="STRING" id="660122.C7Z730"/>
    <dbReference type="GeneID" id="9668222"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76290"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76290"/>
    <dbReference type="eggNOG" id="KOG0835">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022000_5_0_1"/>
    <dbReference type="InParanoid" id="C7Z730"/>
    <dbReference type="OMA" id="WEDVWSV"/>
    <dbReference type="OrthoDB" id="10264655at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU40799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="34272" checksum="ABA6E94897AF6B3E" modified="2009-10-13" version="1">MAHLLNPLATASQLYHRSSFSALPQDLQDAVFIASQCLTQAAGQLLELPQSVTAQANTILARYWLVDSPMANEFSDTSAAAIYLVSKMGPQPRSPRDVSNVYAYLLSDDSAFFRSNSVTENDPKSYYMSETDYHTFQARLLAIEARILYTLSFDTHVSLPHPLAITYLQTLDFLAKPKSAISLRTIQYLNTALLSPQMLYLTHQPHALATAAIYNAARDLGAKMPECEWWEVFDVDREELGFLVVGMRSVENHLRKQKEEIPNLAQGMLTRKTIDEELQKRGVRTGNATSDADEEQRIMGMMDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7T2</accession>
    <name>C7Z7T2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_79547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045456.1">
        <property type="nucleotide sequence ID" value="XM_003045410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7T2"/>
    <dbReference type="GeneID" id="9672496"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79547"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79547"/>
    <dbReference type="HOGENOM" id="CLU_1704709_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z7T2"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="154" mass="16953" checksum="A56DDDDF44ECD83F" modified="2009-10-13" version="1">MPRKKTGICYARQVRRAIIEAYLVSSGSGIPGRVMRVDEDGRYGQDLEAVIGHGSLFDLEGGCATHFPSPSHKADRGPIFVLARDGCRLWAFVTHPGSPGRSPFHSRNATQRNDTSRASFPETTNRGQDESHQKPKVDSLAMRAPLVSPRNIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7V6</accession>
    <name>C7Z7V6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_79572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045471.1">
        <property type="nucleotide sequence ID" value="XM_003045425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7V6"/>
    <dbReference type="GeneID" id="9672633"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79572"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79572"/>
    <dbReference type="eggNOG" id="ENOG502R6SQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038179_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z7V6"/>
    <dbReference type="OMA" id="YTYVHPD"/>
    <dbReference type="OrthoDB" id="3439480at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="343" mass="39703" checksum="DEC217498BF36CAF" modified="2009-10-13" version="1">MCTTNIYTYVYPDGRTEQYSQPTLCANSRHGQVCASNYVFQHPSQLVNYTETTYPTMTQLPPTPQYSPVPSTPSYRSGDESDRSYGSSSSQKKRASGLYIDGRKVLDFHHKKERRPSSKHTDRIVLVDNPPTSRTPPQTWTAPHTAPASPNANAYVIETRDASHRRPVIVDDRAKPERHIIEVVDNHRSSKHVRHASSSSRDSRHSDSEEARKIRREQKREEKRREEAAQRLAIRIAEANAEISSRPAVPAPPRPRRASTYKRPSVEVLNREAELVEAVRRLNFEEEQREEKARKLAKKEEKKEEEAQRRRLMERMQPKRRATVGPGSRRQRVLYDDGVYRWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8D4</accession>
    <name>C7Z8D4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_39412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045563.1">
        <property type="nucleotide sequence ID" value="XM_003045517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8D4"/>
    <dbReference type="STRING" id="660122.C7Z8D4"/>
    <dbReference type="GeneID" id="9672591"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_39412"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_39412"/>
    <dbReference type="eggNOG" id="ENOG502SZ3Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067153_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z8D4"/>
    <dbReference type="OMA" id="DAVWMQW"/>
    <dbReference type="OrthoDB" id="5337308at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="354" mass="39726" checksum="86E26837169258E0" modified="2009-10-13" version="1">MGTRRQLSWRAAFALIPFFSLSLLLLSYVGFPHSSHLNPRASATDHHDAVDNLTKRATDLYEPAREKGAKLHCLMGMSKADAKAANGGASLESPIYLQTDLLPETEGWKYADSKVYFASYLNEALAALNIPREFHHHTWKHLESTEIYDDPTWFVDDNAEPNFNSQPGQASLASFANSFILDPGVIIADKNLGVAEAMKQNLINPNSLTTHIKKWSDMAWIQWFNTCKFQEGDVTTLKYIIRSWITNHTTLSLIFEAILNKNDKDGKGTRIGRWNERITLTVDDNPDEFHAILGSPNGAGSAYLLINHKDKLGVRVINKVDIFVPNIGFDVEGTTVDKDLEARKVMLLFHITKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z963</accession>
    <name>C7Z963_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase C45 hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_81569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045130.1">
        <property type="nucleotide sequence ID" value="XM_003045084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z963"/>
    <dbReference type="STRING" id="660122.C7Z963"/>
    <dbReference type="MEROPS" id="C45.001"/>
    <dbReference type="GeneID" id="9673216"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_81569"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_81569"/>
    <dbReference type="eggNOG" id="ENOG502S05Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037787_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z963"/>
    <dbReference type="OMA" id="IEFYACL"/>
    <dbReference type="OrthoDB" id="189997at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047794">
        <property type="entry name" value="C45_proenzyme-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047801">
        <property type="entry name" value="Peptidase_C45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005079">
        <property type="entry name" value="Peptidase_C45_hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040521">
        <property type="entry name" value="C45_proenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34180:SF1">
        <property type="entry name" value="BETA-ALANYL-DOPAMINE_CARCININE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34180">
        <property type="entry name" value="PEPTIDASE C45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03417">
        <property type="entry name" value="AAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C45 hydrolase" evidence="1">
        <location>
            <begin position="117"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="355" mass="38939" checksum="2652E30C0D8E719C" modified="2009-10-13" version="1">MLQVNCSGTPYEIGHQHGTAAKDKAAGSLDFYKWLFKTTCDMDWPAVRIEAQKYVEPLQKLCPRHVEEMRGVADGAGVEFIDIIALNVRTEITFGLFTDSPSIPVQTDGCTSLAYRQQNGNMLLAQNWDWRVQQTPNLFVCHITQPGTDLPDISFVTEGGVIGKIGFNSSGVGVSLNAIRARGLDTTKLPIHLSLRAALESNSAREAAQKLQETGTAGSGHIMVSDPKEAIGLECTSVGIKEIELDQDGTIVHANHLMLDHPGVDERPPYLDSFARVKRLSQLVAEKAASETIVSSSLFELFKDEQGFPGSINRCQVGESESQTLFNIVMDLAERKATVYFGRPTSWTERVELAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z990</accession>
    <name>C7Z990_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7702 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_81597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045143.1">
        <property type="nucleotide sequence ID" value="XM_003045097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z990"/>
    <dbReference type="STRING" id="660122.C7Z990"/>
    <dbReference type="GeneID" id="9673229"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_81597"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_81597"/>
    <dbReference type="eggNOG" id="ENOG502T3R5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080476_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z990"/>
    <dbReference type="OMA" id="TIYAFSP"/>
    <dbReference type="OrthoDB" id="2560628at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056119">
        <property type="entry name" value="DUF7702"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G00100)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24800">
        <property type="entry name" value="DUF7702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="2">
        <location>
            <begin position="15"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU39430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="284" mass="30830" checksum="DF49D27F26486D2B" modified="2009-10-13" version="1">MSTTNNLPSNNTLNLSYAALGIFGALLLPSVYITWKHGKAGIICWPIFVSFFVLRFVSDAYLIIRKNDPEEPTTVTMMTNAGGIVCLSLTLIGMIYEAVSLIPSRSKRWGRKIMLGATHLGNTVGIGMAAYAGKPDDDAPGGVKDETLNKVGNILMFLVMVVVLFWLWPAMKRVLSARQEVNYKASKALVMAAGPGIVLQLIRLSYSLTYAFNRIASLDPVTGSFATRLVLMFGTQLCIVLVIIAGGWFSKDALPPSLIKVGAADVEMNRASERLVRQQEAGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9C3</accession>
    <name>C7Z9C3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_94444</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045193.1">
        <property type="nucleotide sequence ID" value="XM_003045147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9C3"/>
    <dbReference type="GeneID" id="9673354"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94444"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94444"/>
    <dbReference type="eggNOG" id="KOG0742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004471_5_0_1"/>
    <dbReference type="InParanoid" id="C7Z9C3"/>
    <dbReference type="OMA" id="WTTEFRR"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056599">
        <property type="entry name" value="AAA_lid_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF2">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23232">
        <property type="entry name" value="AAA_lid_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU39480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="239" mass="27275" checksum="E16257ECC132F2D5" modified="2009-10-13" version="1">MGLDIIEGKGQGLLVLLHGGPGTGKTLTAESIAEEQERPLYRVTCGDIGTEPKEVEQVTLSPSPGPVYMLIGSIVLLDEADVFLEERSFSDQKRNAIISIFLRILEYYDGILILTTNRIGSFDEAFKSRIQLALGYPTLDEEDRLKIWGNFVQMLPRTKDRVDMEDLQMNLPKLARDEINGREIRNIITMARHLAKFRKETLRYQHMRDALRSSQKFSEYLTQVKGVSDDDWARADKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9H5</accession>
    <name>C7Z9H5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_62039</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044810.1">
        <property type="nucleotide sequence ID" value="XM_003044764.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9H5"/>
    <dbReference type="FunCoup" id="C7Z9H5">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z9H5"/>
    <dbReference type="GeneID" id="9673795"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_62039"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_62039"/>
    <dbReference type="eggNOG" id="KOG2250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005220_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z9H5"/>
    <dbReference type="OMA" id="DEYGMTS"/>
    <dbReference type="OrthoDB" id="184415at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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    </dbReference>
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        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
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        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NAD-GDH_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055480">
        <property type="entry name" value="NAD-GDH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606:SF24">
        <property type="entry name" value="NAD-SPECIFIC GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23147">
        <property type="entry name" value="GDH2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23152">
        <property type="entry name" value="GDH_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000184">
        <property type="entry name" value="GDH_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="5">
        <location>
            <begin position="682"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1037"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU39097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1037" mass="116235" checksum="2BA7EB150CE02688" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9V7</accession>
    <name>C7Z9V7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Magnesium transporter NIPA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_104817</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045281.1">
        <property type="nucleotide sequence ID" value="XM_003045235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9V7"/>
    <dbReference type="GeneID" id="9672236"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_104817"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_104817"/>
    <dbReference type="eggNOG" id="KOG2922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012349_2_1_1"/>
    <dbReference type="InParanoid" id="C7Z9V7"/>
    <dbReference type="OMA" id="GREQSHD"/>
    <dbReference type="OrthoDB" id="165382at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF65">
        <property type="entry name" value="MAGNESIUM TRANSPORTER NIPA9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="430"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="489"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="629"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="663"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU39568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="693" mass="74473" checksum="433E9A148A75F6AE" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZA82</accession>
    <name>C7ZA82_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_44197</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044941.1">
        <property type="nucleotide sequence ID" value="XM_003044895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZA82"/>
    <dbReference type="STRING" id="660122.C7ZA82"/>
    <dbReference type="GeneID" id="9672123"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_44197"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_44197"/>
    <dbReference type="eggNOG" id="KOG1336">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003291_4_2_1"/>
    <dbReference type="InParanoid" id="C7ZA82"/>
    <dbReference type="OMA" id="PRCTHYG"/>
    <dbReference type="OrthoDB" id="6029at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03478">
        <property type="entry name" value="Rieske_AIFL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050446">
        <property type="entry name" value="FAD-oxidoreductase/Apoptosis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557:SF2">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="10">
        <location>
            <begin position="7"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU39228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="539" mass="57718" checksum="8FA55925965DFF71" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZB35</accession>
    <name>C7ZB35_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_6187</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044576.1">
        <property type="nucleotide sequence ID" value="XM_003044530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZB35"/>
    <dbReference type="GeneID" id="9670770"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_6187"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_6187"/>
    <dbReference type="eggNOG" id="ENOG502SJ1X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_2_0_1"/>
    <dbReference type="InParanoid" id="C7ZB35"/>
    <dbReference type="OMA" id="WVYNLHE"/>
    <dbReference type="OrthoDB" id="3529975at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF64">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="33"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU38863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="303" mass="33552" checksum="2339DED23A3718E0" modified="2009-10-13" version="1" fragment="single">WTYNAPDGAPTSGPQISSLAIVFTSVALLVVIMRVYVRGFMVKAFGADDWIIIATWFASCGFAVVTIIQTKYGLGLKNLEDMPQENYYHFLLLQFIGAPFYISSILGFKLSLLLSYLRFMAAGFWYKATVVVAVACTLFHFSFLMAQVNLCTPVRKQWDASVTGGSCLDGVPMYTAMASITMVFDVVVMLVPFPTLMKLQIPNRKKTVLLGLFAMGTFISIIQIVRIQTIKSLSNLIDSGPLIMWSTVENNLGIIVASVPTLAPLVRYFNEQSRVGSRSRSRSNKGGDSGYALQSNWRKNLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBA3</accession>
    <name>C7ZBA3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PhoD-like phosphatase metallophosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_95126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044496.1">
        <property type="nucleotide sequence ID" value="XM_003044450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBA3"/>
    <dbReference type="STRING" id="660122.C7ZBA3"/>
    <dbReference type="GeneID" id="9672873"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95126"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95126"/>
    <dbReference type="eggNOG" id="ENOG502QPM1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013967_2_0_1"/>
    <dbReference type="InParanoid" id="C7ZBA3"/>
    <dbReference type="OMA" id="AYRQVYA"/>
    <dbReference type="OrthoDB" id="2100241at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052900">
        <property type="entry name" value="Phospholipid_Metab_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606:SF2">
        <property type="entry name" value="ALKALINE PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G03860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase metallophosphatase" evidence="2">
        <location>
            <begin position="210"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU38783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="498" mass="57236" checksum="479B00516A5090B8" modified="2009-10-13" version="1">MNEKTVVVSVLDALIAVSSLTLRYTSILFVRFHPLGRRYLDRIYWSFAIFLFAFITQLLEIEASLYYWHYLTMQDQSLRLPDLSFSRIGFVDSSTARVVIRVPTSDYVDITITSNSDGSVAYVDPILISPVYDYTGTFLIDGLAPNTSYTYSTNASHTGSFRTSVLPQDLKRWSLISSSCIKPFYPYSPLDHGLRIKGLEHLGSYISTNPVEMMLFLGDFIYIDLPIPLGWDAKAYYTAYRQAYASPSWFSQLRAIPWLHVYDDHEIINDWAANETGLYATAMQPFWSYQGHANPPSEFGAGETYYVFQRGGVSFFVLDTRRYRSDNAMADGPEKTMLGEQQRAALVRWLESETDYKVVVSSVPFTRNWRGPDSADSWSGYLWEREQILDTMKRNGGTIILSGDRHEHATTKFPPKKEGEMPVIEFSTSPLNQFYEPFDRFHKEIEDTDISIHSHPWGTSKFGVVSFDTTNKDRLLLHYDLVVDGSTVWQYDWEVQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBH0</accession>
    <name>C7ZBH0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_9711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044568.1">
        <property type="nucleotide sequence ID" value="XM_003044522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBH0"/>
    <dbReference type="GeneID" id="9672752"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_9711"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_9711"/>
    <dbReference type="eggNOG" id="ENOG502SV8Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112091_2_1_1"/>
    <dbReference type="InParanoid" id="C7ZBH0"/>
    <dbReference type="OrthoDB" id="5313995at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019:SF1">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="97" mass="10769" checksum="BFFCCE2FEA7E2A5A" modified="2009-10-13" version="1" fragment="single">PFNTKMSTATIPPFYNFFFKYVDPLIALGGAYLNFFDPISAVTGMAPNSKYDPDQVFLFHQSGGLALAVAFISAVLPRHTTNVTTWRIIQFGLFLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCB7</accession>
    <name>C7ZCB7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_58675</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="GG698918">
        <property type="protein sequence ID" value="EEU38231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043944.1">
        <property type="nucleotide sequence ID" value="XM_003043898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCB7"/>
    <dbReference type="STRING" id="660122.C7ZCB7"/>
    <dbReference type="GeneID" id="9670382"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_58675"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_58675"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZCB7"/>
    <dbReference type="OMA" id="SWSKVPW"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07106">
        <property type="entry name" value="ALDH_AldA-AAD23400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044086">
        <property type="entry name" value="LUC3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="28"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU38231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="487" mass="53098" checksum="1358C4BCC50B001F" modified="2009-10-13" version="1">MTTNGTKKPSLSFTDNFVQYIDGQVTPTSKTRHGINPATLEAKPEVPVATQENLDKAVEAAKRAFKKWSKVPAEERRKAVLAWADAIDAVKDEFRDLLTSEQGKPIPQAQGEADAAVAWIRGMAGIELPEDVIEDSEARTIVTRYTPLGVVAAIIPWNFPLMLATAKIAPALLTGNVIIVKPSPFTPYCGLKLVELAQQFFPPGVVQSLSGDDNLGPWITSHPGIDKISFTGSTHTGKLVLQSASKTLKRVTLELGGNDPAVVFPDVDVDKVAEKVAFFAFLNSGQICLNLKRIYVHESIYSEFRDAMVKHVKAYALGDGSKQGISHGPLQNSMQYNRVKTFFDDIEKQGWKVATGGKMNPEPNGGYFVTPTIIDNPPEKSRIVVEEPFGPILPLMSWKTEEEVIERANDTLLGLGASVWSNDIKKASRVARELDAGTVWVNNHFDITPMAPFGGHKESGIGTEWGANGLKGFCNVQTLFVNKSIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCI9</accession>
    <name>C7ZCI9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_77068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698918">
        <property type="protein sequence ID" value="EEU38375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044088.1">
        <property type="nucleotide sequence ID" value="XM_003044042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCI9"/>
    <dbReference type="GeneID" id="9670311"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77068"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77068"/>
    <dbReference type="eggNOG" id="ENOG502RZ6R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012207_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZCI9"/>
    <dbReference type="OMA" id="ISVRIAM"/>
    <dbReference type="OrthoDB" id="3692311at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="578"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU38375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="650" mass="72052" checksum="A79C174F941E4B12" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCM0</accession>
    <name>C7ZCM0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_34719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698918">
        <property type="protein sequence ID" value="EEU38390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044103.1">
        <property type="nucleotide sequence ID" value="XM_003044057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCM0"/>
    <dbReference type="GeneID" id="9670327"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_34719"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_34719"/>
    <dbReference type="eggNOG" id="ENOG502RFFW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011640_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZCM0"/>
    <dbReference type="OMA" id="ICARCYV"/>
    <dbReference type="OrthoDB" id="5324692at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd06503">
        <property type="entry name" value="ATP-synt_Fo_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1014" mass="113874" checksum="D52B542BD7CEDF8F" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCP2</accession>
    <name>C7ZCP2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_77120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698918">
        <property type="protein sequence ID" value="EEU38296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044009.1">
        <property type="nucleotide sequence ID" value="XM_003043963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCP2"/>
    <dbReference type="STRING" id="660122.C7ZCP2"/>
    <dbReference type="GeneID" id="9670335"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77120"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77120"/>
    <dbReference type="HOGENOM" id="CLU_264194_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZCP2"/>
    <dbReference type="OrthoDB" id="5029321at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF82">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="490"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1268" mass="144265" checksum="216B8DE9C46CA50B" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZD78</accession>
    <name>C7ZD78_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_84476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698919">
        <property type="protein sequence ID" value="EEU38175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043888.1">
        <property type="nucleotide sequence ID" value="XM_003043842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZD78"/>
    <dbReference type="STRING" id="660122.C7ZD78"/>
    <dbReference type="GeneID" id="9670044"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84476"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84476"/>
    <dbReference type="eggNOG" id="ENOG502SRS2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071330_0_1_1"/>
    <dbReference type="InParanoid" id="C7ZD78"/>
    <dbReference type="OMA" id="MICAMGS"/>
    <dbReference type="OrthoDB" id="4161186at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF9">
        <property type="entry name" value="EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU38175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="26259" checksum="44741CF5EB906CB4" modified="2009-10-13" version="1">MKVLIVGASGMIGGEALLQCLANPQISSVVAFVRRELPSDVSNNPKLKSVIIKDFSKWPEDLLLAHADAVGMIWAMGSYGGDVQADLEYPFAFQEAMVRVLKPTGRPFNYVQLSGKFVRQDQETNLWWGSVPRKIKGKLETKTLELAESHPDVWKAFVLKPGGVVPKTMFGSGFLGIVTSLGAVMGENWSVHIEELGAFMMYLALDGQGEEPLLLNDRIVRRGRELLELQKKSQLSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDZ8</accession>
    <name>C7ZDZ8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_54753</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043529.1">
        <property type="nucleotide sequence ID" value="XM_003043483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZDZ8"/>
    <dbReference type="STRING" id="660122.C7ZDZ8"/>
    <dbReference type="GeneID" id="9669749"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_54753"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_54753"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_2_1"/>
    <dbReference type="InParanoid" id="C7ZDZ8"/>
    <dbReference type="OMA" id="THENIMR"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF164">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU37816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="51916" checksum="A519FC6C40709A69" modified="2009-10-13" version="1">MALLSLPLLAGATLLLFVIALVRRLFSPLSRFPGPKLGLLTPWQLRYHELQGKRTQYIHQMHQQYGNVVRVAPNEVVFSSLEAMKEIYLSKGSGYDKPSFYDLFSQFGLRTMFSTREKGPVTSPPDPSQHSKRRRIIADRYANSNVIRDSALHGIQERSQNFIKRCSEAPRQELDVYNANTVPETDMVLGRLFIHYNPTIGSLMGKLGVFGKSRDIPRTRQLILDGATGGPVADFTLVSRMREDKFGMGPMVIASECMDHTLAGIETTGDALCFLMWQISQPGYEIIQERLRDEFLANEGVSFEQLPYLEAVVKEGLRVFPSIPMSLPRCVPPEGASVDGHWLPGGTLVSCQPYSMHRMDEVAFPEPDSFKPERWLEEKGLAERNRLFFTFSNGGRACIGRHLAVAEMKTLMRDIYSTFKTTPAEGMAADMSMDDQIFTSRPKDQKCILKFTRWEEELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZE05</accession>
    <name>C7ZE05_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_88273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043534.1">
        <property type="nucleotide sequence ID" value="XM_003043488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZE05"/>
    <dbReference type="GeneID" id="9669561"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88273"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88273"/>
    <dbReference type="HOGENOM" id="CLU_1759293_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZE05"/>
    <dbReference type="OrthoDB" id="5430750at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="148" mass="15778" checksum="B9443BC2EDC59255" modified="2009-10-13" version="1">MARRNLADCPPTDTTEEDERQPETSGDNDARFQAQEEILHGGDKGLAIPKTTTQSTAAENSVHLEQTLQPYGDEISSNVRSASQGEASDTDGKYSPENTGLEVSAGVETASHSNGNATGGGQELSQLGAIILAKIRQRFLFMLPSRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZE13</accession>
    <name>C7ZE13_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6536 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_88281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043652.1">
        <property type="nucleotide sequence ID" value="XM_003043606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZE13"/>
    <dbReference type="GeneID" id="9669567"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88281"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88281"/>
    <dbReference type="eggNOG" id="ENOG502RYAY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055154_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZE13"/>
    <dbReference type="OMA" id="THWRHLM"/>
    <dbReference type="OrthoDB" id="5429634at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046623">
        <property type="entry name" value="DUF6536"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395:SF1">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20163">
        <property type="entry name" value="DUF6536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6536" evidence="2">
        <location>
            <begin position="5"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU37939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="379" mass="42300" checksum="F5B9C63457A96650" modified="2009-10-13" version="1">MTSGWRFSLITGVASVLVVFIINFSTTLWALKLPTGGEAGDTTTTRRIIYEGPCTTSKKLNVVLHLLINIFSCVLLSASSYGMQCLSAPTRAEVDRAHAREEWMDIGVLSVRNLGKVSCKRTFFWVLLGIFSVPLHLLFNSVVFASISIFDYTAHNIDELVRWNASSRFTRDSDDLQMGELFQRALKENWDNPTSLECIDAYATGFQTARSDVIVVCDGGSDVFLERIYDREDVSLYPGMLRGYCRPSPFDWICEEPDCSLCHDLIADVRKQPENWKPFGYQAKYCLSKPVRQLCRVSFSVFIAGAVLGANIIKAGVLIYVAFNPPEQPLFVLGGAIQTFPETPEPGSKSMRLVSIDRVKNLGTRGCTGPTTSSLRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZE86</accession>
    <name>C7ZE86_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CHR2129</name>
        <name evidence="12" type="ORF">NECHADRAFT_87480</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698921">
        <property type="protein sequence ID" value="EEU37690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043403.1">
        <property type="nucleotide sequence ID" value="XM_003043357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZE86"/>
    <dbReference type="STRING" id="660122.C7ZE86"/>
    <dbReference type="GeneID" id="9669288"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87480"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87480"/>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_2_7_1"/>
    <dbReference type="InParanoid" id="C7ZE86"/>
    <dbReference type="OMA" id="WHERDDT"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF52">
        <property type="entry name" value="SINGLE-STRANDED DNA-DEPENDENT ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="360"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="693"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="775"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU37690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="939" mass="103895" checksum="A9762B1EBCFA9792" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZED4</accession>
    <name>C7ZED4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_53518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698921">
        <property type="protein sequence ID" value="EEU37654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043367.1">
        <property type="nucleotide sequence ID" value="XM_003043321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZED4"/>
    <dbReference type="STRING" id="660122.C7ZED4"/>
    <dbReference type="GeneID" id="9669177"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_53518"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_53518"/>
    <dbReference type="eggNOG" id="ENOG502QV7T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052304_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZED4"/>
    <dbReference type="OMA" id="AMGDLRF"/>
    <dbReference type="OrthoDB" id="408743at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF2">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="10"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="2">
        <location>
            <begin position="151"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU37654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="48408" checksum="F44478AA236CADBC" modified="2009-10-13" version="1">MADKSATRKRYAVVGTGGRSGFYYSAIATDYSATSCIVAFCDTNQTRMNYANSKLKAVGHGEVPTYLAADFDRMIQETKPDEVLVTTIDRTHNTYIVRALELGCNVITEKPMTIDAPRCKEIFSAVERTGQKVRVTFNYRYAPHNTKVFEVLRSGAIGKVTSVHFEWMLNTSHGADYFRRWHRDKRNSGGLLVHKSTHHFDLVNFWLQTRPQTVYATGNLAFYGRENAEKRGETKFYTRAHGSEAAKSDPFALHLDQNPQLKAMYLDAEHEDSYYRDQSVFGDGISIEDTMNLLVTYRNGASLTYSLTAYAPWEGFRVSFNGTGGRLEVEVVENSYVNSGGDQSLEGSLESRKIVLRPLFEKPREIEIEESVGAHGGGDAILLNDLFGEPVSDEYMRAASHVDGAASILTGIAANRSIATGQAVNVDDILVVPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEP9</accession>
    <name>C7ZEP9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_51492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043169.1">
        <property type="nucleotide sequence ID" value="XM_003043123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEP9"/>
    <dbReference type="GeneID" id="9665274"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51492"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51492"/>
    <dbReference type="eggNOG" id="ENOG502SKTI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_663926_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZEP9"/>
    <dbReference type="OMA" id="TDPSEEC"/>
    <dbReference type="OrthoDB" id="5362269at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006270">
        <property type="entry name" value="Strep_his_triad_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04270">
        <property type="entry name" value="Strep_his_triad"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002989220" evidence="2">
        <location>
            <begin position="21"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU37456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="407" mass="43390" checksum="23C03ADAD7C1280E" modified="2009-10-13" version="1" fragment="single">MHLVKFFLATCLSQAWNVSARPRPQAEEACTPHDDHWHCPPGVQPPTTPPGQPDPTSTAQPQPTITAPPATTCLTFLRYMNPKYSTSGAVFSGYSVLWYSSEGTYTRSTGVITVTNTLFYDSNALSSEGYDITTKTSTRTTCVTQTTDGPSATCSPHGDHWHCPPGVEEPTTPPPQETTTSPPTEPTGTCSPHGDHWHCPPGVEEPTTPPAQEPTGTCSPHGDHWHCPPGVEQPTTPPPQETTTTPKEPTGTCSPHGDHWHCPPGVEEPTTPPSQETTTTPKEPTGTCSPHGDHWHCPPGVEEPTTPPPIITSKSTLTTGKDEPTGTCSPHGDHWHCPPGVEEPTTPPPIITSKTTVTTGKDEPTGTCSPHGDHWHCPPGVEEPTTPPPVITSKTTKTTPKDEPTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEW2</accession>
    <name>C7ZEW2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_86318</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043179.1">
        <property type="nucleotide sequence ID" value="XM_003043133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEW2"/>
    <dbReference type="GeneID" id="9665193"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86318"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86318"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008523_10_4_1"/>
    <dbReference type="InParanoid" id="C7ZEW2"/>
    <dbReference type="OMA" id="AEMGPYR"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF432">
        <property type="entry name" value="Y, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006523196" description="Carboxypeptidase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU37466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="488" mass="54241" checksum="EA1B492C39E02035" modified="2009-10-13" version="1">MRIRNALFWALLAPALAMNSDKYVVHKSKFDPSRQMRVKSHPEGAVCDGGVASHSGWADLGNHHMFFWYYESRSAAPDAPVMVWFTGGPGGSSQASALVENGDCKFDRDSQKPTRNPYGWTEEFHMVYIDQPVGVGFSYLDHGNTPSTTDEAAPDVVGFLRLFAESFPHLAKNPLHLAGESYGGRWIPVFGDWVNQYNKVVAEEQRIPLASLIAISAWSHPMVQLPTTYDVACWPFKGYPPALNDTTCTAMAAEYESCKTLLDACDSSQDGIMCGEAAKLCHKGILDYLYTQKVNKYDRRMVCPAPSQCYPIMDEMEAWMNTEAIFEDLLDITNQTSGKKGSYQFMDSQTYLNLVASGDLVVNSLKHIETILQDRVVPVLYTASDADMMVNIKGVGEALDNMRWHGRPFFKNAPFEELPFKTSAGHAGGRVKKSEKLWYAELAEAGHMAPYDQPAGTLELMKIWLAGINHGLVGLRKDDKQSFLGADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEZ5</accession>
    <name>C7ZEZ5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein S-acyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_86352</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.225" evidence="1"/>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043103.1">
        <property type="nucleotide sequence ID" value="XM_003043057.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9665302"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86352"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="611"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="1283"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="1389"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="1422"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="1492"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="1662"/>
            <end position="1694"/>
        </location>
    </feature>
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        <location>
            <begin position="1715"/>
            <end position="1937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="724"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="724"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="744"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU37390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1947" mass="216190" checksum="9E2C31EC9DEC8AE0" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFC9</accession>
    <name>C7ZFC9_FUSV7</name>
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        <recommendedName>
            <fullName evidence="5 6">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">NECHADRAFT_37056</name>
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        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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            <taxon>Fusarium vanettenii</taxon>
        </lineage>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GMC oxidoreductase family.</text>
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    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_37056"/>
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    <dbReference type="OrthoDB" id="413885at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR053208">
        <property type="entry name" value="GMC_Oxidoreductase_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
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    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
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    </dbReference>
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        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190:SF4">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
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    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988801" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="480"/>
            <end position="494"/>
        </location>
    </feature>
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        <location>
            <begin position="775"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="787"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU37222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="799" mass="83791" checksum="F2CA84F1F26B2513" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZH35</accession>
    <name>C7ZH35_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_86584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698927">
        <property type="protein sequence ID" value="EEU36651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042364.1">
        <property type="nucleotide sequence ID" value="XM_003042318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZH35"/>
    <dbReference type="GeneID" id="9669696"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86584"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86584"/>
    <dbReference type="HOGENOM" id="CLU_1595003_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZH35"/>
    <dbReference type="OrthoDB" id="5241738at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU36651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="167" mass="18577" checksum="4B4764D61627D0B3" modified="2009-10-13" version="1">MSLDATRFTMWLQTLVQIMAPHVALPREVIRCSRDRKETRLIERCNPSPLLAQCLAQCLAQCHAQSTGPSATDCKISTPVSQRARTSHYTAAFLIPPEYLFSSRSFAIRATPIPLLAHDRSLGSGLPSPYLQMPSPGFFIPRYKNTLRGETQIHKLANGEQVLGIMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHW7</accession>
    <name>C7ZHW7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_52650</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698929">
        <property type="protein sequence ID" value="EEU36354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042067.1">
        <property type="nucleotide sequence ID" value="XM_003042021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHW7"/>
    <dbReference type="GeneID" id="9674403"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_52650"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_52650"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_6_1"/>
    <dbReference type="InParanoid" id="C7ZHW7"/>
    <dbReference type="OMA" id="WVMGLMA"/>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU36354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="53237" checksum="5E29028F45A2D491" modified="2009-10-13" version="1">MNDHTACPSTSDDDTLRQAPEPTPRPRSLLNLLLDRTRIDDAVEYHEYPGKGTVEEPYIVSFIPDDAGNPFNWSKLARWRITMVSAATCFAVAFSSSAYTGTMKELMFHFRASNTLITGGVSLYVLGFALGPLLWAPLSEIYGRQIVFFISYGLYRSIAMGLFSLAPAMGPTLGPFIGGYLGEDEGWRWVMGLMGIIAGAFWLLGIFLVPETYGPLILKNRAQVLSEKTGKCYISEYDHAGKADPPAVVLKKALIRPWLLLFVEPIVLILSIYTAIVYGTLYMLFGAYPVVFQLERGWSAGKGGLAFLGVAVGMFSAVPTVSLINLWYMKITKAAKGGVVPPEYRLPGSMIGGICVPVGMFWFAWTSYTDIHWMSPVAAGIPFGLGMTLIFHSIFNYLIDAYAIYAASVLAANTVLRSLFGAAFPLFTKQMYDKLGTQWASSVPAFLALACLPMPFILWKYGPAIRSRCKYSAKAATATGSQETKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZIK1</accession>
    <name>C7ZIK1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_53042</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698931">
        <property type="protein sequence ID" value="EEU36103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041816.1">
        <property type="nucleotide sequence ID" value="XM_003041770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZIK1"/>
    <dbReference type="STRING" id="660122.C7ZIK1"/>
    <dbReference type="GeneID" id="9674206"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_53042"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_53042"/>
    <dbReference type="eggNOG" id="KOG0070">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_9_3_1"/>
    <dbReference type="InParanoid" id="C7ZIK1"/>
    <dbReference type="OMA" id="EYCIFDY"/>
    <dbReference type="OrthoDB" id="442317at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="20"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="123"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU36103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="18302" checksum="287EED30BB7FC5CA" modified="2009-10-13" version="1">MGQVISSVWTPQKITVGLVGLPSAGKSAIIWHLLHRAVPAKIPPRSMIEVDTITRNGQSFDLFDFVGDEKLRACWRSFFAPKDAIIFVVDSADRDSMDEAGEELHRLFLVERLEFKPIVVFANKQDSPEAMSVDELVDVLGIRGELEKDKRCVGICTAPHEAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZIQ5</accession>
    <name>C7ZIQ5_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_97545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698931">
        <property type="protein sequence ID" value="EEU36067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041780.1">
        <property type="nucleotide sequence ID" value="XM_003041734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZIQ5"/>
    <dbReference type="STRING" id="660122.C7ZIQ5"/>
    <dbReference type="GeneID" id="9674170"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_97545"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_97545"/>
    <dbReference type="eggNOG" id="ENOG502SS8U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062263_0_1_1"/>
    <dbReference type="InParanoid" id="C7ZIQ5"/>
    <dbReference type="OMA" id="NNGICAI"/>
    <dbReference type="OrthoDB" id="89086at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008701">
        <property type="entry name" value="NPP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33657">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33657:SF6">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05630">
        <property type="entry name" value="NPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029958">
        <property type="entry name" value="Necrosis-inducing_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002989304" evidence="2">
        <location>
            <begin position="19"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU36067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="252" mass="27195" checksum="4625EC6F875A9835" modified="2009-10-13" version="1">MHKNFVAAAALLSAVASGTPVHKRDVIGALPEGADQLELKFQPHLDFDSDGCYQTSAIDPNGNVNPGHGATGTPQGDCRDPHQLENSNTYSRKRCNNGFCAVMYEYYFEKDQAVGGSFLGGHRHDWENIVVFTQGDNVVRVAPSCHGGYGGASNQFPIDGSSPLLVYHKDGAGTHCFRFANDDDRNNPENPTGSFFRAPLVGWDNWPDVGLRDKMLQNWSGGVGPKLDDEFGNSLQAAAGDGVQGFDPFTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJ69</accession>
    <name>C7ZJ69_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_49778</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698932">
        <property type="protein sequence ID" value="EEU36024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041737.1">
        <property type="nucleotide sequence ID" value="XM_003041691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJ69"/>
    <dbReference type="STRING" id="660122.C7ZJ69"/>
    <dbReference type="GeneID" id="9674015"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_49778"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_49778"/>
    <dbReference type="eggNOG" id="ENOG502RY37">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065859_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZJ69"/>
    <dbReference type="OMA" id="TNEGRFT"/>
    <dbReference type="OrthoDB" id="2141316at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695:SF1">
        <property type="entry name" value="RHAMNOGALACTURONAN ACETYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988155" evidence="4">
        <location>
            <begin position="21"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU36024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="258" mass="27505" checksum="ECEB7B1E66841A87" modified="2009-10-13" version="1">MKFTISSLTALALGAISAAAAPTVYFCGDSTMAKNGANDGSTDGWGNYIGQYLTAPVVNKAIGGRSARSYWNEGRFQEVANLVKSGDIVVIEFGHNDGGSPEKNDNKRSDCPGAGKETCISDVTGETVYTFVFYVSQAAKLMTAKGATVILSSQTPNNQWETGTFNSAAPRFVGYQQTATKALASSSVTYVDHFQAVTNMYQKLGKDAVNAFFPKDHTHTSPAAAKAVAQAFVQAVYEELNGKTSLKPYVKTPITKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJD0</accession>
    <name>C7ZJD0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_77212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698933">
        <property type="protein sequence ID" value="EEU35828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041541.1">
        <property type="nucleotide sequence ID" value="XM_003041495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJD0"/>
    <dbReference type="STRING" id="660122.C7ZJD0"/>
    <dbReference type="GeneID" id="9673968"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77212"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77212"/>
    <dbReference type="eggNOG" id="ENOG502RZ77">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002639_6_2_1"/>
    <dbReference type="InParanoid" id="C7ZJD0"/>
    <dbReference type="OMA" id="KECTTHH"/>
    <dbReference type="OrthoDB" id="5125733at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="234"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="680" mass="76628" checksum="94DD1BE9B9A7ECB5" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJE2</accession>
    <name>C7ZJE2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_34878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698933">
        <property type="protein sequence ID" value="EEU35834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041547.1">
        <property type="nucleotide sequence ID" value="XM_003041501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJE2"/>
    <dbReference type="FunCoup" id="C7ZJE2">
        <property type="interactions" value="203"/>
    </dbReference>
    <dbReference type="GeneID" id="9673898"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_34878"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_34878"/>
    <dbReference type="eggNOG" id="KOG1576">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_7_0_1"/>
    <dbReference type="InParanoid" id="C7ZJE2"/>
    <dbReference type="OMA" id="FPRSSYK"/>
    <dbReference type="OrthoDB" id="5286008at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045290">
        <property type="term" value="F:D-arabinose 1-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070485">
        <property type="term" value="P:dehydro-D-arabinono-1,4-lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19164">
        <property type="entry name" value="AKR_ARA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044480">
        <property type="entry name" value="Ara2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686:SF1">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="14"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU35834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="384" mass="42759" checksum="A97E9CF7EA0B25FB" modified="2009-10-13" version="1">MATLRKPLSDVLPPLILGTATFNHQYHPDPAHMPYTDIVGRALAHNILGFDTSPYYGPSEILLGDALRKLTPPPPREGYFLITKAGRIASDEFDYSPAWIRYSVCRSLERLGTPYLDLVYTHDVEFVSPEEVLGAVMELRRLRDQGLIRYVGISGYPVDTLASLAEMILRETGEPLDAVLSYGHFCVQNSQLGEKALLERFKDAGVECLLNASMLNMGLLTTRGVDNSPMATWHPAPGELRQLCSNLSAIAQQEGEHLEEVAIRWALENWARVGSPFGTKLNPGSSSRLGVSVMGVSSVDELEETWNLWSSVVGLADAEAQRREKIARIVKDKMWPTLGRWKDFEWESGGPKFVNARIEMGVVPRDGTAERWRLIPSVLDTLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJK9</accession>
    <name>C7ZJK9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_55738</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698934">
        <property type="protein sequence ID" value="EEU35801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041514.1">
        <property type="nucleotide sequence ID" value="XM_003041468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJK9"/>
    <dbReference type="GeneID" id="9673879"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55738"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55738"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="InParanoid" id="C7ZJK9"/>
    <dbReference type="OMA" id="FTYFGQI"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF66">
        <property type="entry name" value="MFS HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="41"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU35801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="530" mass="59439" checksum="FA1DBBB7CD315687" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJN6</accession>
    <name>C7ZJN6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylacetyl-CoA ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_44354</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698935">
        <property type="protein sequence ID" value="EEU35770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041483.1">
        <property type="nucleotide sequence ID" value="XM_003041437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJN6"/>
    <dbReference type="STRING" id="660122.C7ZJN6"/>
    <dbReference type="GeneID" id="9676318"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_44354"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_44354"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="InParanoid" id="C7ZJN6"/>
    <dbReference type="OMA" id="WTFRHRI"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="48"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="466"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU35770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="61415" checksum="9E54667FB8B297AA" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJN9</accession>
    <name>C7ZJN9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_26685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698935">
        <property type="protein sequence ID" value="EEU35736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041449.1">
        <property type="nucleotide sequence ID" value="XM_003041403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJN9"/>
    <dbReference type="GeneID" id="9676320"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_26685"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_26685"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_6_3_1"/>
    <dbReference type="InParanoid" id="C7ZJN9"/>
    <dbReference type="OMA" id="HTFPTAW"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="91"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU35736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="341" mass="37485" checksum="2AEDFF1E7CAFEBDB" modified="2009-10-13" version="1" fragment="single">MCDFSEYGGKSPEWLAVEATLPPPPTFGSLEERKRVVNKGREEISAKSMESLSHLVHINDYRIGTRDGATVEARGYRPTSADPATRLPIYIHLHGGGYLFGSLSSEDAICTRIASGAMVIVINVNYRHTPEATYPMAWDDAEDAFHWVHDHIEELFGDDSQVLVGGISAGAQLAAALALTQNLSPNALLRPELAGQVLMIPCLIHMDCYQSQLEQLKDPSVSSYLENEHAPILPTKTAKFFTELLKITNPNPQDLRLNPGNASEHQVGGLPPTVLGIAGLDPLRDEGLLYGKRLAEAGVSTDVHVFKGLPHGFRRFGEQLTESERWDKVMEEGIRWALSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZK36</accession>
    <name>C7ZK36_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tat pathway signal sequence domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_52435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698937">
        <property type="protein sequence ID" value="EEU35608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041321.1">
        <property type="nucleotide sequence ID" value="XM_003041275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZK36"/>
    <dbReference type="GeneID" id="9676119"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_52435"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_52435"/>
    <dbReference type="eggNOG" id="ENOG502RK4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005777_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZK36"/>
    <dbReference type="OMA" id="MDLRFYH"/>
    <dbReference type="OrthoDB" id="4798501at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045793">
        <property type="entry name" value="PcRGLX/YetA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048330">
        <property type="entry name" value="PcRGLX/YetA_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048331">
        <property type="entry name" value="PcRGLX/YetA_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048329">
        <property type="entry name" value="PcRGLX_1st"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40081">
        <property type="entry name" value="CONCANAVALIN A-LIKE LECTIN/GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40081:SF1">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19501">
        <property type="entry name" value="PcRGLX_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21345">
        <property type="entry name" value="PcRGLX_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21346">
        <property type="entry name" value="PcRGLX_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PcRGLX/YetA-like N-terminal RIFT barrel" evidence="1">
        <location>
            <begin position="15"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="PcRGLX/YetA-like central beta-sandwich" evidence="2">
        <location>
            <begin position="113"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="PcRGLX/YetA-like C-terminal alpha/alpha toroid" evidence="3">
        <location>
            <begin position="485"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU35608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="911" mass="101102" checksum="DACAC65CECCDCE70" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKS9</accession>
    <name>C7ZKS9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Inositol oxygenase</fullName>
            <ecNumber evidence="4 14">1.13.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 14">Myo-inositol oxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NECHADRAFT_69919</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>myo-inositol + O2 = D-glucuronate + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23696"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="EC" id="1.13.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="13 14">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the myo-inositol oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.99.1" evidence="4 14"/>
    <dbReference type="EMBL" id="GG698941">
        <property type="protein sequence ID" value="EEU35350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041063.1">
        <property type="nucleotide sequence ID" value="XM_003041017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKS9"/>
    <dbReference type="STRING" id="660122.C7ZKS9"/>
    <dbReference type="GeneID" id="9675658"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_69919"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_69919"/>
    <dbReference type="eggNOG" id="KOG1573">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050259_0_1_1"/>
    <dbReference type="InParanoid" id="C7ZKS9"/>
    <dbReference type="OMA" id="RYNTKYG"/>
    <dbReference type="OrthoDB" id="5151075at2759"/>
    <dbReference type="UniPathway" id="UPA00111">
        <property type="reaction ID" value="UER00527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050113">
        <property type="term" value="F:inositol oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007828">
        <property type="entry name" value="Inositol_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588:SF0">
        <property type="entry name" value="INOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588">
        <property type="entry name" value="MYOINOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05153">
        <property type="entry name" value="MIOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="105"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="164"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="242"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU35350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="308" mass="35856" checksum="D28A8431B1B7114F" modified="2009-10-13" version="1">MAPGAVVDDFTSHDGQALEVLSDKIDDVNVIKYDEKSKFDTEKDKNTFRQYADATDRVKNFYREQHHKQTVSYNLAARNRFYNATRPRAEMTIWEAMEKLNTLVDESDPDTSLSQIQHLLQSAEAIRRDGKPRWMQLTGLIHDLGKLMLFFPELETQGQWDVVGDTFPVGCAFSDKIIYPETFAEGNPDASNPDYNTKYGIYSPNCGLDNIMLSWGHDEYLYHVVKDQSTLPDEALAMIRYHSFYPWHREGAYRHLMCDKDHEMIKAVQAFNPYDLYSKSDGVPDAEKLKPYYMELIDEYFPQRVLKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLI8</accession>
    <name>C7ZLI8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_88690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698945">
        <property type="protein sequence ID" value="EEU35124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040837.1">
        <property type="nucleotide sequence ID" value="XM_003040791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLI8"/>
    <dbReference type="GeneID" id="9679270"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88690"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88690"/>
    <dbReference type="HOGENOM" id="CLU_517857_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZLI8"/>
    <dbReference type="OrthoDB" id="5070069at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU35124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="526" mass="59192" checksum="5FD2A42E9D18B333" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLT7</accession>
    <name>C7ZLT7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RTA1 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_78598</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698947">
        <property type="protein sequence ID" value="EEU35017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040730.1">
        <property type="nucleotide sequence ID" value="XM_003040684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLT7"/>
    <dbReference type="GeneID" id="9679147"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78598"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78598"/>
    <dbReference type="eggNOG" id="ENOG502RDNH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033465_0_1_1"/>
    <dbReference type="InParanoid" id="C7ZLT7"/>
    <dbReference type="OMA" id="HEWFFYV"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF13">
        <property type="entry name" value="RTA1 DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU35017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="39361" checksum="47D86508DA211D0C" modified="2009-10-13" version="1">MSDGKYGKFTLFVDGSYWFYAPNKGAAIFFCITFCASGCVHAWQSSHYKCWILTPLFAFCCLLFTAGFALREYGAFHYDNLNIFIASICITYAAPPLLELQNYHILGRILYYVPYHSPIHPGRVLTTFGFVSAIIESLNGWGASYSANQSLSDKAIATGHALIKASLLLQVIVLVLFVVLATVFHHRCISNGVRNDRLQSSLITLYISTTLILARTIYRIIEYFSVAELRYGPGFDPSTINPVVRYEWFFYVFEAAVMLINTVMFNVRHPRRYLPKSNKIYLAPDGVTEVEGPGFKDPRPFWQTLIDPFDIIGLTTGKGRETERFWETNDDTTTRDSVRTKSDVETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLT8</accession>
    <name>C7ZLT8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_92385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698947">
        <property type="protein sequence ID" value="EEU35018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040731.1">
        <property type="nucleotide sequence ID" value="XM_003040685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLT8"/>
    <dbReference type="GeneID" id="9679148"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_92385"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_92385"/>
    <dbReference type="eggNOG" id="ENOG502RR5Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036424_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZLT8"/>
    <dbReference type="OMA" id="IYVHLEM"/>
    <dbReference type="OrthoDB" id="5207413at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="401" mass="45748" checksum="72C408DD3DEA6C4A" modified="2009-10-13" version="1">MGDRPAVYVHFELGVSWPKHLSKDRHITYISKSMRDRANQFPRQLPPVNTNYLAAPTQYQVAYQQPVPQIQEPQAHPPYQLTYYTNEIPPNTYNRDPVTPAPAQTVQYQPYQPVQQPQHYSQEYYAPVASVQPPVEEEEVRGSSRSMSRSSHERGRSAPPPFNDSPWDVGSSSNSQGVPQLWKALPATPNQYRLGEDNMPWSTWSFPMGYNENEDEGDDGERGESRSREASIRATWGPEFPGEPARRPESDDRHRGKAKDIQSLATALMTVDNGFEDQWWYQGPRLVNLHGTVLVPTAVPKSSFHPDFQQGSVGWAVSREEEMRQKDQLQQHQQRQHQQQQQQQQRQQLESFVPSTPSFQVVSPRSSVADIVSPLSEYPSPLSSFGGLRRSLTTRSDELHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMJ0</accession>
    <name>C7ZMJ0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Knr4/Smi1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_82393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698953">
        <property type="protein sequence ID" value="EEU34758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040471.1">
        <property type="nucleotide sequence ID" value="XM_003040425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMJ0"/>
    <dbReference type="GeneID" id="9678917"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82393"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82393"/>
    <dbReference type="eggNOG" id="ENOG502SXC4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_572495_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZMJ0"/>
    <dbReference type="OMA" id="EDIPCGT"/>
    <dbReference type="OrthoDB" id="2788868at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Knr4/Smi1-like" evidence="1">
        <location>
            <begin position="275"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="477" mass="53532" checksum="67CA56B10A821245" modified="2009-10-13" version="1">MAPFKKFDADTVLTSRDVPALYHSMLELAKEFAVLGQIKTAKSLTSLLLSQYSSNWQLRQVSSLKFAFAEIGEWPDQIPQEERTEEALNDLAKSITSDFGNESDAEEDDPAELGVLLETARGSDASSGGAAMERSNALATALAMTIRLASKQTSSIEEIEADPKVQKALGYIGVRMHSNKAIDCLTQHRTNWLLLSTSALARKIPVDMAKVEAFGQEVVDTFTERMKNGRRPHPREDKSIKELLDELDRNTRANGTSQYEAMGEEVPGSLFILPPATDEQISALERKLDVVLPDDYKEFFKISNGFGGTWNGYYLEPPLHGVDDVDWAEFYGDILPIELHETPTGNMDLDLRGGREWPTYGRPIELGTWDVLEALFITPHDTKRAIEAYKECLESPETPDALKEHTRKLIASKYGSWEAFEKLEWVAMDQHDADSVTHGTFTQFLQERVRQSEMGRWQGQGQRDLASFAYSYMADDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMW1</accession>
    <name>C7ZMW1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Short-chain dehydrogenase/reductase 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Retinal short-chain dehydrogenase/reductase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_34821</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698959">
        <property type="protein sequence ID" value="EEU34635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040348.1">
        <property type="nucleotide sequence ID" value="XM_003040302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMW1"/>
    <dbReference type="GeneID" id="9678794"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_34821"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_34821"/>
    <dbReference type="eggNOG" id="KOG1201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_5_2_1"/>
    <dbReference type="InParanoid" id="C7ZMW1"/>
    <dbReference type="OMA" id="CDITTVE"/>
    <dbReference type="OrthoDB" id="10253736at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000131">
        <property type="entry name" value="Short-chain dehydrogenase/reductase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU34635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="358" mass="38855" checksum="FCAFB40E92A0648B" modified="2009-10-13" version="1">MTSLLYSPAIEYISQLGRIILSPFLTGPLLLIATHAPHLAHDALASVISRLPDSVTASLKPATIKLALQVLVGLGLIRSLNKTLNTMAHNSWRLRASKGWDWPNEIAVVTGGSSGIGKDIVKRLVSLGVQVAVLDVQDLPKDLQENPRVSFYHCDVTSAESVAEAADALRRELGHPSILINNAGITKPTPILKMPESFLRRIFGVNVMALWFTTQQFLPRMIQLDKGHVVTVASIASFVALPTGADYSATKAGALSFHESLACELKHFYKSPNVLTTVVHPNFVRTPLVEDFADHLQSSGVRFLTSDQIASEVVGQIKSRRGGQLIIPRSASAISGIRGWPTWLQELLRDGIGKGAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMY8</accession>
    <name>C7ZMY8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_94818</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698960">
        <property type="protein sequence ID" value="EEU34617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040330.1">
        <property type="nucleotide sequence ID" value="XM_003040284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMY8"/>
    <dbReference type="STRING" id="660122.C7ZMY8"/>
    <dbReference type="GeneID" id="9678742"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94818"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94818"/>
    <dbReference type="eggNOG" id="KOG3923">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034311_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZMY8"/>
    <dbReference type="OMA" id="PRVENEF"/>
    <dbReference type="OrthoDB" id="409956at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF16">
        <property type="entry name" value="D-AMINO ACID OXIDASE (AFU_ORTHOLOGUE AFUA_5G11290)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988966" description="FAD dependent oxidoreductase domain-containing protein" evidence="7">
        <location>
            <begin position="19"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="8">
        <location>
            <begin position="5"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU34617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="362" mass="39624" checksum="46397A54F1A3FCC8" modified="2009-10-13" version="1">MTNTVVVVGAGVIGLTSALLLAKEEGNDVTVVAKHMPGDYDAEYASPWAGANVIPLAPKEGSRWERRTWVALKKLTEETPEAGIHFQTTHVIRRNKDMEADASGFSSHFYQDNPWFKEIFKNFRENHPSEIASGYDSGFQYQGICMNTAIFLPWILGQCLKHGVTVKRGILAHIEEAKYLSHTGRTANIIVNATGLGSLKLGGVEDTTVAPSRGQIVVVRNETPKNFPLFMCSSTLDGSGEEIYAMQRAAGGGTVIGGTYQIGNWDSQPDPNTANRIMERIVTLCPEIAGGKGVSGLSVVRHGVGFRPWRKDGLRLEEEKLDDETWIIHNYGHSGWGYMGSFGCAEGVLELVEKVTKTRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPJ9</accession>
    <name>C7ZPJ9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_105471</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039871.1">
        <property type="nucleotide sequence ID" value="XM_003039825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZPJ9"/>
    <dbReference type="GeneID" id="9677747"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_105471"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_105471"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_3_1"/>
    <dbReference type="InParanoid" id="C7ZPJ9"/>
    <dbReference type="OMA" id="WRWAYYT"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF50">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="44"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU34158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="529" mass="57898" checksum="F165294CE189D623" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPV1</accession>
    <name>C7ZPV1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PhyH-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_54493</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698973">
        <property type="protein sequence ID" value="EEU33972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039685.1">
        <property type="nucleotide sequence ID" value="XM_003039639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZPV1"/>
    <dbReference type="FunCoup" id="C7ZPV1">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZPV1"/>
    <dbReference type="GeneID" id="9667191"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_54493"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_54493"/>
    <dbReference type="eggNOG" id="ENOG502RUKM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047725_0_1_1"/>
    <dbReference type="InParanoid" id="C7ZPV1"/>
    <dbReference type="OMA" id="IGSVWHG"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF45">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU33972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="34081" checksum="06B053210DF3ED4B" modified="2009-10-13" version="1">MPNPPHQAHNPEVVELDASVPVQDIVEVIKRDGGIIIKNFLSPETIDKIHEEAEPYWGKLGTYQGKLFDAGDPPLSGFAGKSPTFSHKAINHPTFREVAKALLKEESNVYRDGNRYTCVSNPVLAVSEAFNRGSPSTAQQLHRDDMAQHFDHLEGSGESSLLGLLVAGVDTNFVNGATQVIVGSHKWPEAAIKGPADRSLCSTCEMSKGDAVFIIGSIWHGAGENKTNPPERRIIYSCHMTRGSLRADENQYLAIEHDTIKTYDPEVQALLGYSVSHPNCGHVDMKDPITLLGSKSDPFGYGDIGGKQIVKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZRE9</accession>
    <name>C7ZRE9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_89500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG699071">
        <property type="protein sequence ID" value="EEU33407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039120.1">
        <property type="nucleotide sequence ID" value="XM_003039074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZRE9"/>
    <dbReference type="STRING" id="660122.C7ZRE9"/>
    <dbReference type="GeneID" id="9666642"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89500"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89500"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_2_1"/>
    <dbReference type="InParanoid" id="C7ZRE9"/>
    <dbReference type="OMA" id="TFYRAKT"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU33407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="49369" checksum="90211D74F2D03DDD" modified="2009-10-13" version="1">MALLLQYFLALSGLICFYLGHSIIYNLFFHPFRKFPGPPLAKISRVWSRRANFQGLKYMRIHEAHQKYGAVIRIGPNELSFADPLAIRDIYTTDDFQKEESFYFSKRGYEEDHLFSFTNPEAHSQRRKLLSRGYSQRSLLAIEQELSTKIQIFLQVIGKDSADGKPVDIYNRVHLLSFDVVYWLLFGDDPKSLESGGEHKVLSYFRAWRPIFIYKEFWPQLEKIGIYLPGALGENFRKVKAWKEYSVDLIRKCRQNTVVTPFFRSVLYGEKDGYLDRPLTDSEVAEECMSGMFGGTGTTANTFVFLLWATLQHPGVVEKLKAELRAAIPNVGSVPDYQAVINETLRLYPTIVAIIPRIAMRDTSVAGVHIQKGTIVGIQNYTIHRWEPAFPEPERFIPDRWLDDENIEQRKEAFVPFSVGSRRCIGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7YGW8</accession>
    <name>C7YGW8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Rhamnogalacturonate lyase</fullName>
            <ecNumber evidence="11">4.2.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">NECHADRAFT_31607</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Endotype eliminative cleavage of L-alpha-rhamnopyranosyl-(1-&gt;4)-alpha-D-galactopyranosyluronic acid bonds of rhamnogalacturonan I domains in ramified hairy regions of pectin leaving L-rhamnopyranose at the reducing end and 4-deoxy-4,5-unsaturated D-galactopyranosyluronic acid at the non-reducing end.</text>
            <dbReference type="EC" id="4.2.2.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the polysaccharide lyase 4 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.23" evidence="11"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054243.1">
        <property type="nucleotide sequence ID" value="XM_003054197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YGW8"/>
    <dbReference type="STRING" id="660122.C7YGW8"/>
    <dbReference type="GeneID" id="9664324"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_31607"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_31607"/>
    <dbReference type="eggNOG" id="ENOG502QTKY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037882_1_1_1"/>
    <dbReference type="InParanoid" id="C7YGW8"/>
    <dbReference type="OMA" id="FKIGDWD"/>
    <dbReference type="OrthoDB" id="114708at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102210">
        <property type="term" value="F:rhamnogalacturonan endolyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10317">
        <property type="entry name" value="RGL4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10316">
        <property type="entry name" value="RGL4_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10320">
        <property type="entry name" value="RGL4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000102">
        <property type="entry name" value="Rhamnogalacturonate lyase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029413">
        <property type="entry name" value="RG-lyase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029411">
        <property type="entry name" value="RG-lyase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016590">
        <property type="entry name" value="Rhamnogalacturonase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015364">
        <property type="entry name" value="RhgB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36574">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36574:SF1">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14683">
        <property type="entry name" value="CBM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14686">
        <property type="entry name" value="fn3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09284">
        <property type="entry name" value="RhgB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011794">
        <property type="entry name" value="Rhamnogalacturonase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010009727" description="Rhamnogalacturonate lyase" evidence="11">
        <location>
            <begin position="19"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase B N-terminal" evidence="13">
        <location>
            <begin position="20"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="15">
        <location>
            <begin position="285"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="14">
        <location>
            <begin position="374"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="48"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR011794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR011794-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEU48530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="540" mass="58157" checksum="B16C750F227DE72B" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIE0</accession>
    <name>C7YIE0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_98938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053793.1">
        <property type="nucleotide sequence ID" value="XM_003053747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIE0"/>
    <dbReference type="STRING" id="660122.C7YIE0"/>
    <dbReference type="GeneID" id="9676422"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_98938"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98938"/>
    <dbReference type="eggNOG" id="ENOG502SEZ3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014855_1_0_1"/>
    <dbReference type="InParanoid" id="C7YIE0"/>
    <dbReference type="OMA" id="WAAHTGK"/>
    <dbReference type="OrthoDB" id="5593352at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039712">
        <property type="entry name" value="Meu6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039483">
        <property type="entry name" value="Meu6_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42073">
        <property type="entry name" value="MEIOTIC EXPRESSION UP-REGULATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42073:SF1">
        <property type="entry name" value="MEIOTIC EXPRESSION UP-REGULATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15406">
        <property type="entry name" value="PH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="76"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="555"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU48080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="568" mass="61169" checksum="375C391D9344E994" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIG9</accession>
    <name>C7YIG9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS17 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_73418</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053807.1">
        <property type="nucleotide sequence ID" value="XM_003053761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIG9"/>
    <dbReference type="FunCoup" id="C7YIG9">
        <property type="interactions" value="1131"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YIG9"/>
    <dbReference type="GeneID" id="9676437"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_73418"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_73418"/>
    <dbReference type="eggNOG" id="KOG1728">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073626_0_1_1"/>
    <dbReference type="InParanoid" id="C7YIG9"/>
    <dbReference type="OMA" id="DYEKCPF"/>
    <dbReference type="OrthoDB" id="10254436at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.1000:FF:000001">
        <property type="entry name" value="40S ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028333">
        <property type="entry name" value="Ribosomal_uS17_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_uS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032440">
        <property type="entry name" value="Ribosomal_uS17_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03630">
        <property type="entry name" value="uS17_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF9">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16205">
        <property type="entry name" value="Ribosomal_S17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS17 N-terminal" evidence="6">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU48094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="157" mass="18003" checksum="04350B30C7DCF46A" modified="2009-10-13" version="1" fragment="single">LTVQSERAFQKQPHIFQNSKARTKSTRPGKGGRRWYKDVGLGFRTPKAAIEGSYIDKKCPFTGLVSIRGRILTGTVVSTKMHRTIIIRREYLHFIPKYSRYEKRHKNVAAHVSPAFRVMEGDQVTVGQCRPLSKTVRFNVLRVLPRTGNAVKKFSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIQ0</accession>
    <name>C7YIQ0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_75402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054555.1">
        <property type="nucleotide sequence ID" value="XM_003054509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIQ0"/>
    <dbReference type="GeneID" id="9664681"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75402"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75402"/>
    <dbReference type="eggNOG" id="ENOG502SPG3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099558_0_0_1"/>
    <dbReference type="InParanoid" id="C7YIQ0"/>
    <dbReference type="OMA" id="KISYTHW"/>
    <dbReference type="OrthoDB" id="5366688at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU48842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="20187" checksum="F738D674792C112B" modified="2009-10-13" version="1">MQPALGALGHTWTAMRAMECISFITIIGLTSNFISEMVGADYAAPSALIGTLVVACISTLYIAISYILYWDGMLPLLLATGADLCLLIACIVVACTVGKPVSYLSCPKFPSDGNTANFINSLFHNVYHSQANTFRWVDADKASCYQIKSIWGLSIALCVLFAFSAITSGCLWKRTKGASRPAPKDIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJ63</accession>
    <name>C7YJ63_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_75569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054641.1">
        <property type="nucleotide sequence ID" value="XM_003054595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJ63"/>
    <dbReference type="GeneID" id="9663708"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75569"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75569"/>
    <dbReference type="HOGENOM" id="CLU_1190181_0_0_1"/>
    <dbReference type="InParanoid" id="C7YJ63"/>
    <dbReference type="OrthoDB" id="4980804at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU48928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="233" mass="26863" checksum="0B6F04BCEADA8826" modified="2009-10-13" version="1">MPEYAWLPSLDFSQDADVVQERPVRQPIRWPGELTAAEKAALLDLLQAGAEMLPEAPLPVTRMHFDRLMELVFSDKWNSRVGGTKINGPKLMWSFTDAEGKMVEPKYIDDTTGVLEAMVDLKAELIQEYDRHEEKRVREYNTCCIVNLARRRIARFSKAGTENPPCVDVRDLPKHLVRLTRAQDIVTAMANSCEIERDSETEEDEIKKEDEIKKEEEIKKEEEIKKEDDSESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7YL17</accession>
    <name>C7YL17_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_77370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052889.1">
        <property type="nucleotide sequence ID" value="XM_003052843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YL17"/>
    <dbReference type="STRING" id="660122.C7YL17"/>
    <dbReference type="GeneID" id="9670960"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77370"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77370"/>
    <dbReference type="eggNOG" id="ENOG502SHSN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004184_7_2_1"/>
    <dbReference type="InParanoid" id="C7YL17"/>
    <dbReference type="OMA" id="LIWDTDF"/>
    <dbReference type="OrthoDB" id="4476201at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="90"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU47176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="754" mass="85174" checksum="2ADDEEC2DFEF0247" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7YL57</accession>
    <name>C7YL57_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_77412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052444.1">
        <property type="nucleotide sequence ID" value="XM_003052398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YL57"/>
    <dbReference type="GeneID" id="9663604"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77412"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77412"/>
    <dbReference type="eggNOG" id="ENOG502S6M4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_667384_0_0_1"/>
    <dbReference type="InParanoid" id="C7YL57"/>
    <dbReference type="OMA" id="ENALTWC"/>
    <dbReference type="OrthoDB" id="5217806at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU46731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="425" mass="47544" checksum="FF421B93C38015AF" modified="2009-10-13" version="1">MALYEYEKYLIARGALLVVTAWIPASILFFCALCLTRRRKDPARTAFTYLKLALPVFAGYAFFDICSVALTIAVVRERDDYYYGSYDAIRAIQITSSSTAIISNFFDKIVDILVMIMLLRISTGIVIAQSGHAGPIGKILRLGSYAFSTLLAILTIAALGLNIRFLATFYGDSIYVSDSEAPGEDAYNKARQIDFAFRVLVFVAALGIVARSVMVKMQPKAEKTLSWCSTMLIAMSIAWLLRTTYCMASIAAWSDFSNSRNDRYEYYYNILDVVFAVWPQFTVLCMIFALGTAKAKGLWSTPQPFNAPQGNQQTAWGYSYNNGPQPTAPPMVQQQPQFQQPQQQYQQPQQHQYQQQYQQPQPVSPVQQGWQPQQPQQTYSAYTPSSPSQTTRSPPPHEETMGFNHQADGTPPSVSPHPYGTKAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLC1</accession>
    <name>C7YLC1_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_77477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052474.1">
        <property type="nucleotide sequence ID" value="XM_003052428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YLC1"/>
    <dbReference type="GeneID" id="9663638"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77477"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77477"/>
    <dbReference type="eggNOG" id="ENOG502RMBH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_823967_0_0_1"/>
    <dbReference type="InParanoid" id="C7YLC1"/>
    <dbReference type="OMA" id="VHASFEP"/>
    <dbReference type="OrthoDB" id="5081908at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU46761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="363" mass="40134" checksum="AEC006177F1C2381" modified="2009-10-13" version="1">MSSEPSDTAEADHNDSPPKAPKTSSKASTAADVLKALRDEERRMIRFILPEAKKHPEVYAKVIAKIKSSKIRDPRRWRESGFIRNFIGWLAMTNKDARPDLEDAIAVLAIFDCYSSNAPSKFRTSLVEHGLRVWATRKLKGERASTEQGSPETLRTSPKAPKVKQETILPSIEFDQIAPRASSTAAQGVKRPADDPPAEHPPKRTVSKAEHEALAAQVARIDEAVAARLPIISSRSFGTQTSPPPREAVMKLVSAITEQQGKHNQTLAEHSRALREQGRALVDFPSTVREVVRQEIQRTIVPVSNDTSIFQRSQAHGPSYTVIANQPMPSYAFDTAGEFQIVEAPQGRAAGSRFNSRFGMYDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C7YM91</accession>
    <name>C7YM91_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TATA-box binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_67389</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052617.1">
        <property type="nucleotide sequence ID" value="XM_003052571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YM91"/>
    <dbReference type="FunCoup" id="C7YM91">
        <property type="interactions" value="1062"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YM91"/>
    <dbReference type="GeneID" id="9671149"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_67389"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_67389"/>
    <dbReference type="eggNOG" id="KOG3302">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060161_1_0_1"/>
    <dbReference type="InParanoid" id="C7YM91"/>
    <dbReference type="OMA" id="FHFKIAE"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000120">
        <property type="term" value="C:RNA polymerase I transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097718">
        <property type="term" value="F:disordered domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008301">
        <property type="term" value="F:DNA binding, bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001179">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000979">
        <property type="term" value="F:RNA polymerase II core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001092">
        <property type="term" value="F:TFIIA-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001188">
        <property type="term" value="P:RNA polymerase I preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070898">
        <property type="term" value="P:RNA polymerase III preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="20"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU46904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="27307" checksum="17FD5D0F5B6B2428" modified="2009-10-13" version="1">MEGIQTHPSNAAQAKAFTAPGSLSFPGATNELTPPAGNGNAAQLPAPNGQQAANGNGVTPATPAATPAATQGPSGITPTLQNIVATVNLDCRLDLKTIALHARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVVTGAKSEDDSKLASRKYARIIQKLGFNAKFTDFKIQNIVGSCDIKFPIRLEGLASRHHNFSSYEPELFPGLIYRMIKPKIVLLIFVSGKIVLTGAKVREEIYQAFEMIYPVLQDFRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7YMD4</accession>
    <name>C7YMD4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF899 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_77841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053145.1">
        <property type="nucleotide sequence ID" value="XM_003053099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YMD4"/>
    <dbReference type="GeneID" id="9671171"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77841"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77841"/>
    <dbReference type="eggNOG" id="ENOG502S6FI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066898_2_0_1"/>
    <dbReference type="InParanoid" id="C7YMD4"/>
    <dbReference type="OMA" id="YHFMLGP"/>
    <dbReference type="OrthoDB" id="3503208at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010296">
        <property type="entry name" value="DUF899_thioredox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05988">
        <property type="entry name" value="DUF899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU47432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="27247" checksum="C9F86A76C1E4B184" modified="2009-10-13" version="1">MTRKIVNRQDWLTARKDFLEKEKEHTRAGDALAAERRNLPMVKVDKTYTFEGPDGTTTSLADLFGDNDQLIVYHFMFKPGDDEGCRGCSHVGESLPDPRHLNFKNTAFACVSRAPAKKLEEYKKRNGWTWPWYSSGDSDFNYDFFATIDEARGKALLNFRTKDEVEAKGQTWWEGGDVPGYSVFLKEDGEIYHTYSTFARGGETVLTTLMMLDMTPLGRQVGQYGPAEFKLKDEYASSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7YML8</accession>
    <name>C7YML8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoadenylyl-sulfate reductase (thioredoxin)</fullName>
            <ecNumber evidence="3">1.8.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">3'-phosphoadenylylsulfate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">PAPS reductase, thioredoxin dependent</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">PAdoPS reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_67534</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[thioredoxin]-disulfide + sulfite + adenosine 3',5'-bisphosphate + 2 H(+) = [thioredoxin]-dithiol + 3'-phosphoadenylyl sulfate</text>
            <dbReference type="Rhea" id="RHEA:11724"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="EC" id="1.8.4.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.8" evidence="3"/>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052685.1">
        <property type="nucleotide sequence ID" value="XM_003052639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YML8"/>
    <dbReference type="FunCoup" id="C7YML8">
        <property type="interactions" value="629"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YML8"/>
    <dbReference type="GeneID" id="9664099"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_67534"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_67534"/>
    <dbReference type="eggNOG" id="KOG0189">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044089_0_1_1"/>
    <dbReference type="InParanoid" id="C7YML8"/>
    <dbReference type="OMA" id="PIARWTQ"/>
    <dbReference type="OrthoDB" id="7869097at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23945">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000151">
        <property type="entry name" value="Phosphoadenosine phosphosulfate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011800">
        <property type="entry name" value="PAPS_reductase_CysH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02057">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002537">
        <property type="entry name" value="PRK02090.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509:SF1">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="13">
        <location>
            <begin position="78"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU46972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="316" mass="35940" checksum="858C21C84E36A294" modified="2009-10-13" version="1">MPAFISQSSSQSSFQDIKLECESGYVSGQNSEYSSPSSSTILPQISLTKAHIEHLNNMLETMHPMDILRFCKVMFPNLYQSTAFGLTGLVTMDMLSKIQKEHPNSPTVDLIFLDTLYHFQETHDLVNRVKARYPNVPVHIFKPDGVNTAEEFEDMYGKEMWNTASEMYDWIVKVEPLQRAYEELKVAAVLNGRRRSQGAARGSIPIIEYDDERAVVKINPLATWSFKQVNDYIKEHNVPYNALLDQGYKSVGDWHSTVPVKDGEDERAGRWKGQAKTECGIHNKKSRYAEFLAQMEQKQQEEKLAAALEQVALPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>C7YMN9</accession>
    <name>C7YMN9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent RNA helicase SUB2</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ATP-dependent RNA helicase sub2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">NECHADRAFT_59311</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 also plays a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the DEAD box helicase family. DECD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052696.1">
        <property type="nucleotide sequence ID" value="XM_003052650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YMN9"/>
    <dbReference type="FunCoup" id="C7YMN9">
        <property type="interactions" value="1223"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YMN9"/>
    <dbReference type="GeneID" id="9664109"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_59311"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_59311"/>
    <dbReference type="eggNOG" id="KOG0329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_1"/>
    <dbReference type="InParanoid" id="C7YMN9"/>
    <dbReference type="OMA" id="YAHVEPK"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000346">
        <property type="term" value="C:transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17950">
        <property type="entry name" value="DEADc_DDX39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000111">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000168">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase 56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="22">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="20">
        <location>
            <begin position="81"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="21">
        <location>
            <begin position="268"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="18">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EEU46983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="434" mass="48971" checksum="EE209AEC16D80E21" modified="2009-10-13" version="1">MSHEEDLIDYSDEEIGGNETAATTSNGKKGELAAGNNVDKKGSYVGIHSTGFRDFLLKAELLRAIADCGFEHPSEVQQTCIPQALLGGDIICQAKSGLGKTAVFVLATLQQVEPVNGEVSVVVMCHTRELAYQIRDEYNRFSKYMPDIKTGVFYGGTPIKTDVETLKNKETCPHIIVGTPGRLKALVRDKALRLGSVRIFVLDECDKMLDQPDMRTDVQDVFRATPQQKQVMMFSATLSEEVKPICRKFMQNPTEHYVDEDTKLTLHGLQQYYIKLEEKEKNRKLNELLDDLQFNQVIIFVRSTVRATELDKLLRECNFPSIAVHSGVSQEERIRRYKEFKEFKKRICVATDVFGRGIDIERINLAINYDLSNDASSYLHRVGRAGRFGTKGLAISFVSTDQDQEVLKEIEKRFEVALPEFPKEGVDASTYMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7YN54</accession>
    <name>C7YN54_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_78111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052778.1">
        <property type="nucleotide sequence ID" value="XM_003052732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YN54"/>
    <dbReference type="STRING" id="660122.C7YN54"/>
    <dbReference type="GeneID" id="9664342"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78111"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78111"/>
    <dbReference type="eggNOG" id="ENOG502RVVB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040048_2_0_1"/>
    <dbReference type="InParanoid" id="C7YN54"/>
    <dbReference type="OMA" id="CHELYIT"/>
    <dbReference type="OrthoDB" id="2687876at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU47065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="40835" checksum="6AF6344EBA297A66" modified="2009-10-13" version="1">MPRTPSSFHGLAHVPRRQRPENRISILLFNNTRPLSNGITAFHNIMVGLSTYHSDADDSTRRGRIRRKQQPIKPLDETRKYCSFSIFINGFKTGLFHWFVLLYTDLPSLTRFRRVNRRAMDLVDSVPQYAAIIKHCPNIIRAILSIQADSFNCHVLYTTLSTTRCFTCERFGDPLYLIDCRRVCYFCFTRRLEYFPLTIGRASSFFAPNGTQRRNAITSRQHLRAANPPSVLSLPGRYCTAWASGGGNLVRKRLQLFDRGAVIQDLAGSGLPKVDKTTREPLRFMAIITAPHLFDSGPRADWGYFCLGCKEEKEEKTKHFRIKYTREEVSEHIAKYGPVKETPRIPGRFMHVTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPN6</accession>
    <name>C7YPN6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pirin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_68167</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052038.1">
        <property type="nucleotide sequence ID" value="XM_003051992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YPN6"/>
    <dbReference type="GeneID" id="9668747"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_68167"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_68167"/>
    <dbReference type="eggNOG" id="ENOG502QQ5A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045717_0_2_1"/>
    <dbReference type="InParanoid" id="C7YPN6"/>
    <dbReference type="OMA" id="TPWHPHR"/>
    <dbReference type="OrthoDB" id="198735at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd02247">
        <property type="entry name" value="cupin_pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02909">
        <property type="entry name" value="cupin_pirin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903:SF8">
        <property type="entry name" value="PIRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin N-terminal" evidence="3">
        <location>
            <begin position="85"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin C-terminal" evidence="4">
        <location>
            <begin position="238"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU46325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="40416" checksum="4FF2C2900D2425EC" modified="2009-10-13" version="1">MTLFRNIITIISLLVALTAIVLFQHRIQDTTTVAFEFIKTLTPAAFFISNNKTNTDHHLYATEMSVSRTIRKVFLAIEQSEGAGARVRRSIGTPQLRNFSPFLMLDHFSIKPGAGFPDHPHRGQETITYLLEGGVDHEDFAGNKGTIHAGDLQFMTAGKGIVHSEMPAQNFDTNVGLQLWVDLPSNLKACEPRYRDLRASEIPIAKVDDDRVTVKVISGQSHGIDSVKDLAYTPVWILDIEIRPGGKITQPLPQNWNAFAYTLEGDVIVGKDDQRRVVEQFHNIVFEPQGDVVHFEVDAGATKPARLALVAGTPLDQPVVQYGPFVLTSKEEVAKALFDYQTHSNGFERAKDWESEIGKSMLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQH4</accession>
    <name>C7YQH4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histidine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Histidyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">NECHADRAFT_92750</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the aminoacylation of histidyl-tRNA in both the cytoplasm and the mitochondrion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="3"/>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052186.1">
        <property type="nucleotide sequence ID" value="XM_003052140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQH4"/>
    <dbReference type="FunCoup" id="C7YQH4">
        <property type="interactions" value="876"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YQH4"/>
    <dbReference type="GeneID" id="9673564"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_92750"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_92750"/>
    <dbReference type="eggNOG" id="KOG1936">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025113_4_0_1"/>
    <dbReference type="InParanoid" id="C7YQH4"/>
    <dbReference type="OMA" id="CGGGNFK"/>
    <dbReference type="OrthoDB" id="1906957at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000015">
        <property type="entry name" value="Histidyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000021">
        <property type="entry name" value="Probable histidine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="16">
        <location>
            <begin position="14"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="300"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="510"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="518"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="83"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="285"/>
            <end position="286"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001549-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEU46473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="544" mass="60146" checksum="F75E7902DFEAEAEC" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQJ7</accession>
    <name>C7YQJ7_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_79129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051749.1">
        <property type="nucleotide sequence ID" value="XM_003051703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQJ7"/>
    <dbReference type="STRING" id="660122.C7YQJ7"/>
    <dbReference type="GeneID" id="9672662"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79129"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79129"/>
    <dbReference type="eggNOG" id="KOG4497">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024072_2_0_1"/>
    <dbReference type="InParanoid" id="C7YQJ7"/>
    <dbReference type="OMA" id="CWHLNGD"/>
    <dbReference type="OrthoDB" id="308690at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990811">
        <property type="term" value="C:MWP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990810">
        <property type="term" value="P:microtubule anchoring at mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052778">
        <property type="entry name" value="Centrosome-WD_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220">
        <property type="entry name" value="WD REPEAT PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN WRAP73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU46036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="510" mass="55473" checksum="4A950229B597BA7F" modified="2009-10-13" version="1">MHPSRVFKSSPHCTASPDGRLVATLSSQSITVRSTLSLSIVHQVKLPSDLPTPVSTLAWAPSSSRILVASADQIHVFSITDSSFRATIRNPAPGGGKQALVQFGAHETEIFACAAFGLKFIIFDLSTSKAIEIANPKFYLPSSASRGYSVRPHTSHLAILTRTSGRDVVSIHHPGTRQVLRSWYPDTADAHGLTWTPDGRWLLLWESPAHGHKLLLYTPDGELFRSIGASSIVGGQDADLETGIKLCRLSPDASLCAVGDHSRTVGVLNTQTWRDGLKLVHPTTIVPKDTLQVWQEQLNPSSLGGPSHTFLRATQMISPPSRLVDGKPSPDVKPGCSSLAFDASSSLLATRLDDTPTTLWIWDVTSAELRAVLLFHSSVDFQWHPDAREVLLITCQDDKYRGISFVWDPLSEGPKQVSLQAHLPNGKMVGKTRTAWINGETEFPVLLLSDAQHYVLMSCADAEQCPTPWGEASGDRTFGSMQDIGDTVDVSALMPDDTSTLDDTFSFKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQQ3</accession>
    <name>C7YQQ3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M24 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_100138</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051775.1">
        <property type="nucleotide sequence ID" value="XM_003051729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQQ3"/>
    <dbReference type="STRING" id="660122.C7YQQ3"/>
    <dbReference type="GeneID" id="9673602"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100138"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100138"/>
    <dbReference type="eggNOG" id="KOG2776">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041451_2_1_1"/>
    <dbReference type="InParanoid" id="C7YQQ3"/>
    <dbReference type="OMA" id="SRMFYSE"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd01089">
        <property type="entry name" value="PA2G4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000029">
        <property type="entry name" value="Proliferation-associated 2G4, a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000016">
        <property type="entry name" value="Putative curved dna-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047113">
        <property type="entry name" value="PA2G4/ARX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804:SF11">
        <property type="entry name" value="PROLIFERATION-ASSOCIATED PROTEIN 2G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804">
        <property type="entry name" value="PROTEASE FAMILY M24 METHIONYL AMINOPEPTIDASE, AMINOPEPTIDASE P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="3">
        <location>
            <begin position="19"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="374"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU46062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="405" mass="44319" checksum="4CCD790DF7ED2C69" modified="2009-10-13" version="1">MSDNKEIDYTLANPDTLTKYKTAAQISEKVLAEVSKLVVPGAKIVDICQQGDKLIEEEIAKVYRGKKINKGFSHPTTVSPASYVTPYTPLTSDEAEAGIEIKEGEPIKIQLGAQIDGFGSIVCDTVVATPEDKAGEPVTGRTADLILANYYVNELLLRLMIPPGLLAQGTDEEKAKAAAQKAPTQSKITSLLEKVTKAYDVNLVESTTSWLFDRNEIEGSKKIVLAPAEGTKGDGTPEISEVWGVEVGVSLGSGKVKSIDQRPTLHRRTNQTYGLKRPTSRKILSEVQKKFGTFPFSLRQLEDERDAKSGVVECVRGNVFRQYELVGDKDNAQVARYLTTIAITKNGITKLGAPPPLDLEKYQSDKKIEDEEVLKILEQPTARNTGKKKSKPKKKAKKEGEADAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7YR95</accession>
    <name>C7YR95_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_102641</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051131.1">
        <property type="nucleotide sequence ID" value="XM_003051085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YR95"/>
    <dbReference type="FunCoup" id="C7YR95">
        <property type="interactions" value="405"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YR95"/>
    <dbReference type="GeneID" id="9667826"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102641"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102641"/>
    <dbReference type="eggNOG" id="KOG0934">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061221_0_0_1"/>
    <dbReference type="InParanoid" id="C7YR95"/>
    <dbReference type="OMA" id="KAYHILD"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14831">
        <property type="entry name" value="AP1_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000007">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044733">
        <property type="entry name" value="AP1_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="10">
        <location>
            <begin position="3"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU45418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="155" mass="18158" checksum="CB9F05FDE615187C" modified="2009-10-13" version="1">MAIQYLILLSRQGKVRLAKWFTTLSPKDKAKIVKDVSQLVLARRTRMCNFLEYKDTKIVYRRYASLFFIAGCSSEDNELITLEIIHRYVEQMDKYYGNVCELDIIFSFTKAYYILDELLLAGELQESSKKNVLRCIGQQDSLEDMEVEDEVTKIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRH3</accession>
    <name>C7YRH3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[acyl-carrier-protein] S-malonyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_41721</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
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</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
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        <name evidence="2" type="ORF">NECHADRAFT_100606</name>
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        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
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                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050309.1">
        <property type="nucleotide sequence ID" value="XM_003050263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YTC7"/>
    <dbReference type="STRING" id="660122.C7YTC7"/>
    <dbReference type="GeneID" id="9665721"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84540"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84540"/>
    <dbReference type="eggNOG" id="ENOG502S7ZW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047725_1_0_1"/>
    <dbReference type="InParanoid" id="C7YTC7"/>
    <dbReference type="OMA" id="GYWMNTS"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF19">
        <property type="entry name" value="MULTIFUNCTIONAL DIOXYGENASE AUSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU44596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="34264" checksum="AC5EFD1623B3D92D" modified="2009-10-13" version="1">MQTMTVTSSTAPAQSLKPTGPVRRVPRDTPVAEIASIFAQDGAIIVEQFLSSDQVDRLNTDLDEPLKKLTPAGLLNGVPDEAREFFGVATRRLTNLITLSKTWREEIINDNLMHDICEEILTKKTGGYWLSAAQMMEIGPGNPKQPLHRDFGNWWPNFDMPPTAPETMLNFLMATTDTTEENGATRAIPGSHLWPYSADDHNLGSEDLTQTCPLKAGDMMMIGGRIVHGGGRNSTSDFFRRVVSVVAVTNCFTQEEAYALTLDLEMVRKMPLRLQKFLGFRSQYPKGSPGLWSINAKHIGEHIGLSTME</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7YTF7</accession>
    <name>C7YTF7_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_48982</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049951.1">
        <property type="nucleotide sequence ID" value="XM_003049905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YTF7"/>
    <dbReference type="FunCoup" id="C7YTF7">
        <property type="interactions" value="339"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YTF7"/>
    <dbReference type="GeneID" id="9665730"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_48982"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_48982"/>
    <dbReference type="eggNOG" id="KOG3080">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036007_2_0_1"/>
    <dbReference type="InParanoid" id="C7YTF7"/>
    <dbReference type="OMA" id="DAHKGRD"/>
    <dbReference type="OrthoDB" id="443772at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008610">
        <property type="entry name" value="Ebp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028">
        <property type="entry name" value="RRNA PROCESSING PROTEIN EBNA1-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028:SF0">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EBP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05890">
        <property type="entry name" value="Ebp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="18"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="330"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="399"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU44238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="414" mass="45963" checksum="AAC4D3A2DE8B5439" modified="2009-10-13" version="1">MVTKGKLKMALAAEKGTDFKKLKLKRKQKEAEKRNKAARRGAAEESDEEEEIENEVAEGDDDEDEEDEEKSQLERHTDQYQYNLEGIDDSDDSDSSIELEEKIPRKSKKSASPAAKKVADEEDDEEEEDDEDIPMSDLEDLDDADKEDLIPHQRLTINNTTALLAALNRIAIPSDKSVPFATHQSVLAGSETSASIPDVQDDLQRELAFYSQSLDAARQARKLLRAEGVPFSRPKDYFAEMVKEDAHMEKVKAKLVEEASNKKAAAEARKLRDLKKFGKQVQVAKLQERQKAKRETLEKIKTLKRKRQESGGADLGTNEADLFDVGVESEMKKHNQRSGAGRGQMGAGSGTVNHKRAKKNEKYGFGGKKRHAKSGDAMSSSDLSGFNAKKMKAGGSKVSKARPGKARRKAMGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7YTP8</accession>
    <name>C7YTP8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase family 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_48978</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049994.1">
        <property type="nucleotide sequence ID" value="XM_003049948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YTP8"/>
    <dbReference type="FunCoup" id="C7YTP8">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="GeneID" id="9675158"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_48978"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_48978"/>
    <dbReference type="eggNOG" id="KOG4472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024327_4_3_1"/>
    <dbReference type="InParanoid" id="C7YTP8"/>
    <dbReference type="OMA" id="WCFFLYQ"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF7">
        <property type="entry name" value="MANNOSYLTRANSFERASE KTR4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU44281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="394" mass="46571" checksum="0EB1F4B605E15566" modified="2009-10-13" version="1">MTVARPVRALIAVGTILWCFFLFQIFAPSWGLTGPGERYSNFERDPNLDPTDEPEGVLHRTSPRYAYDAKKTERIDATLLALVRNEEVDAMVSSMRDLERTWNSKFNYPWTFFNDKPFTEEFKRKTSAATKAKCNYEVIPAEHWDAPSWIDNQIFDESAKILEKNGVQYARKLSYHQMCRWNSGLFYKHPALKDIRYYWRVEPNVHFFCDVDYDVFRYMHDHNKTYGFTINLYDDPKTLPSLWPETVKFLAEHPDYIHENSAVKWVTDDIRRPSTNKKAQGYSTCHFWSNFEIADMEFWRSKPYEDYFNHLDRAGGFFYERWGDAPVHSIALGLFEDSSKIHWFRDIGYQHIPFFNCPNSPKCKGCVTGRLTDGEAWLHREDCRPNWFKYAGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7YUM5</accession>
    <name>C7YUM5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_84974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050544.1">
        <property type="nucleotide sequence ID" value="XM_003050498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YUM5"/>
    <dbReference type="GeneID" id="9665592"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84974"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84974"/>
    <dbReference type="eggNOG" id="ENOG502TDDR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_767454_0_0_1"/>
    <dbReference type="InParanoid" id="C7YUM5"/>
    <dbReference type="OrthoDB" id="4974265at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="263"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU44831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="41655" checksum="F8719955D897B7E4" modified="2009-10-13" version="1">METASPDRLSSLPLETLYELFSCVEAGAPLDFRWPSHDPKWWVLNIEEGDQPLQVAMMHYQVEAVEWMLGQGVNPYEKDDNGKRRTLELICESRLLKGHYEKKLQVAARWRHKRLHIPDRDVLALRGRRMFDSLLRAGALLNPRLTRALQWKPDQVEAKPVEVKGYICQDPLSLLPRKILLKVLSHLSPVNGGCSLVLTSRFLYQTLILDLYRETGRQMSWLPIFVGALDGNLLTLQACLRAGAPIDHQWEGNHLRSGWRFSRRIRPLHVAVDYAQISSVRWLLDKGANPEVAPGDERSSPHLRAWFKALVPPYPDSRQVLWWRQKDFTVPHQETLKEEYRGILELLQSFTASSFNALMCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7YV98</accession>
    <name>C7YV98_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HpcH/HpaI aldolase/citrate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_48742</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HpcH/HpaI aldolase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050258.1">
        <property type="nucleotide sequence ID" value="XM_003050212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YV98"/>
    <dbReference type="STRING" id="660122.C7YV98"/>
    <dbReference type="GeneID" id="9674689"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_48742"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_48742"/>
    <dbReference type="eggNOG" id="ENOG502RMPQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059964_3_0_1"/>
    <dbReference type="InParanoid" id="C7YV98"/>
    <dbReference type="OMA" id="HQVQIGC"/>
    <dbReference type="OrthoDB" id="1621678at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="4">
        <location>
            <begin position="15"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU44545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="245" mass="27127" checksum="405BB40552D63477" modified="2009-10-13" version="1">MVGCINRRLNYTLSPSSNFDWVLIDAEHGLISDKDYYELTNAIASEGASPIIRVSWNEEWMIKRALDAGCHGVLTPMCHSADDARKIVQYSKYPPLGSRGYGPMFATHSFYRLLAGQYDERANKDLLVAVQIESRSAVENVEEIAKVEGVDVLLIGPFDLAKQMGVTRGSPEHEEAIQRTLKAAKNAGKKTAIFCTNGAQARSRAQEGFDMVSIITDLGVLEEGIMRELAVATDVRPQEKGRDQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVI4</accession>
    <name>C7YVI4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_85286</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050695.1">
        <property type="nucleotide sequence ID" value="XM_003050649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVI4"/>
    <dbReference type="STRING" id="660122.C7YVI4"/>
    <dbReference type="GeneID" id="9675093"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85286"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85286"/>
    <dbReference type="HOGENOM" id="CLU_004542_0_0_1"/>
    <dbReference type="InParanoid" id="C7YVI4"/>
    <dbReference type="OMA" id="YEMEAGQ"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF27">
        <property type="entry name" value="BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type III-like" evidence="7">
        <location>
            <begin position="218"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU44982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="310" mass="34931" checksum="1D8C9A0445093BA7" modified="2009-10-13" version="1">MSWMFSRSGVWANRVVINDNVSPSGAVLATAGLRFGCCEKIDAQTTISKAIELATEVYIPIVIAGLNSDYETEYSDRVSLDLPPGVDKLIQQVIRANPNMIIVTQAGSPIAMPWVQDAHTLLHAWYGGQETGNAIADMLFRKASRGYTYFHYGEGVFIDYWYYEELRIRPYFFFGHGLPYTIFEFVNLQALISFSLDGDSSIEVCVEVLNSGGHDGWEVVQLYISDKESSVLRPIKELKGFTKVWIKASETITAKVSLDKYAFSFWDELMDKWVAEKGLYQIIVATSADPKDEILRHDIMPLEDFAWSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVU9</accession>
    <name>C7YVU9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_74084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049778.1">
        <property type="nucleotide sequence ID" value="XM_003049732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVU9"/>
    <dbReference type="GeneID" id="9677353"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74084"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74084"/>
    <dbReference type="eggNOG" id="ENOG502T5UC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_289195_0_0_1"/>
    <dbReference type="InParanoid" id="C7YVU9"/>
    <dbReference type="OMA" id="KHESAVG"/>
    <dbReference type="OrthoDB" id="5383650at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="522"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="424"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU44065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1061" mass="119162" checksum="50CF5E87004B93FA" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWJ5</accession>
    <name>C7YWJ5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Replicase polyprotein 1a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_29911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049906.1">
        <property type="nucleotide sequence ID" value="XM_003049860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWJ5"/>
    <dbReference type="GeneID" id="9677257"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_29911"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_29911"/>
    <dbReference type="eggNOG" id="ENOG502S7CI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045844_0_0_1"/>
    <dbReference type="InParanoid" id="C7YWJ5"/>
    <dbReference type="OMA" id="QEWEHTD"/>
    <dbReference type="OrthoDB" id="5320532at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008402">
        <property type="entry name" value="APC_su15/mnd2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05841">
        <property type="entry name" value="Apc15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU44193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="40404" checksum="B18B29C729C0AB63" modified="2009-10-13" version="1">MFTTLPDFTPRDSHLLWYRSSRSSFSPPGPLEELNNESQNPQNAGHQSRQRGKIIERSALARLASDEQYMQRRRLNIQNYGSGWLKPPGVPKTLHQMREEKREQEEHQEAMRREQLAQELAEAEAEGMPEDGTMDDVQLDGAQDLDDEIPDADDGFGFDDDEDDDEDDEEEEEEEDEDDDATEADESALREERQNDLMASQIRMNDDTFREALVRGEPDAGDMYGDGDDLEAEDNGHLLDEDDFTQEGTDDGLGVDMDADLDDDIPEAESGGYEHTDSEAELTSSEEEPDEEEEDEDDDDADVSYAPRSTTLPPPRSPTFHGRSSMSHPRVSMDLSNLLSQDGSSFMESSPAGRRARQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWP4</accession>
    <name>C7YWP4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_74373</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU43993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049706.1">
        <property type="nucleotide sequence ID" value="XM_003049660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWP4"/>
    <dbReference type="STRING" id="660122.C7YWP4"/>
    <dbReference type="GeneID" id="9677281"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74373"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74373"/>
    <dbReference type="eggNOG" id="KOG3981">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053595_0_2_1"/>
    <dbReference type="InParanoid" id="C7YWP4"/>
    <dbReference type="OMA" id="AAYCVNP"/>
    <dbReference type="OrthoDB" id="70823at2759"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000198">
        <property type="entry name" value="Deoxyribose-phosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="9">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001357-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU43993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="262" mass="28030" checksum="EC17F4D46C50C92D" modified="2009-10-13" version="1">MTATNEITVTLRQLAKMIDHSLLHPTMTDADILSGLAIAKKYNVATACVKPYLIPLAKKELEGSEVLVCPVIGFPHGNSTTEVKVFEADAAAAAGGKEIDMVINIGKALGGDWEYVADEIRQINDAVVKHGAILKVIFENDYLEENHIVKLCEICSDIGVGFVKTSTGYGFVKQPNGLYSYKGATVPHLKLMRESSKPEVQVKAAGGVRTLDDLLHVMSLGVTRIGATATVAIMEDAVKRGITDEPTTVKFKPIDSGSAGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXG8</accession>
    <name>C7YXG8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_45190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049050.1">
        <property type="nucleotide sequence ID" value="XM_003049004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXG8"/>
    <dbReference type="FunCoup" id="C7YXG8">
        <property type="interactions" value="835"/>
    </dbReference>
    <dbReference type="GeneID" id="9666282"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45190"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45190"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_0_0_1"/>
    <dbReference type="InParanoid" id="C7YXG8"/>
    <dbReference type="OMA" id="YEGTLMC"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000138">
        <property type="entry name" value="NADPH dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU43337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="361" mass="39520" checksum="569137D3BC8566AF" modified="2009-10-13" version="1">MAKLFTPLKVGAMSLSQRIAMAPMTRLRASDSHVPLPSVKEYYKQRASAPGSLVVTEATVISPRHGGYANVPGIYNQSQIDAWREVTSAVHANGSYIFLQLWALGRAANPQSLQQAGHQMVSSSDVPMKSAFSDEMHYPTPLTEDGIHGAISDFAVAAKNAISAGFDGVEIHGANGYLVDQFIQDVSNKRTDNWGGSIENRSRFAVEVTRAVVEAVGRERTAIRLSPWSKYQGMRMDDPVPQFSDLVHRLADFKLAYLHACESDAKQSGEDIKFILDTYADASPVLVAGNYDAASAKNAVDVEYANHDVVVAFGRPYISNPDLVFKAKKGIEFAPFDPKTMYAQSDEGYIDYPFAQEAKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXM4</accession>
    <name>C7YXM4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_45449</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049326.1">
        <property type="nucleotide sequence ID" value="XM_003049280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXM4"/>
    <dbReference type="STRING" id="660122.C7YXM4"/>
    <dbReference type="GeneID" id="9666382"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45449"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45449"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_6_2_1"/>
    <dbReference type="InParanoid" id="C7YXM4"/>
    <dbReference type="OMA" id="FMLWRRL"/>
    <dbReference type="OrthoDB" id="10054429at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF5">
        <property type="entry name" value="GABA TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU43613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="55373" checksum="F63FE620E63F49B5" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXQ3</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">NECHADRAFT_82610</name>
    </gene>
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        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="660122.C7YXQ3"/>
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    <dbReference type="KEGG" id="nhe:NECHADRAFT_82610"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82610"/>
    <dbReference type="eggNOG" id="ENOG502SKSW">
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    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEU43384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="548" mass="62690" checksum="41F6AE92570F6C5A" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXU2</accession>
    <name>C7YXU2_FUSV7</name>
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        <recommendedName>
            <fullName evidence="4">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">NECHADRAFT_82649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012768083" description="Peptidase A1 domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU43400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="27218" checksum="16FE7C5D900E18E3" modified="2009-10-13" version="1">MRLSLVLPFLGSVWAAPTEPSSESFPSIFDNPTIPTVNPAELGIPDDSPLFRRAAATTQGKIFLNLSRCELKVARDGGWSFKAESRNAVLWIAQGLPSPGTKNGQNPYDLYVDAGIPTASVGSSGSVQFLTNAYMKSLPSPGTSVDDYAKVTIPSGNTIKADINFSNVPIEKQPNRFNALLVDSKGAVGPVTLFYPDSGFVSALVADKGDVTGWVWLNGYSDPTATSMTHRGFYYAKITGFCIKSGGPWTFVPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXY4</accession>
    <name>C7YXY4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alcohol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_45493</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049129.1">
        <property type="nucleotide sequence ID" value="XM_003049083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXY4"/>
    <dbReference type="FunCoup" id="C7YXY4">
        <property type="interactions" value="882"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YXY4"/>
    <dbReference type="GeneID" id="9677021"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45493"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45493"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_1_1"/>
    <dbReference type="InParanoid" id="C7YXY4"/>
    <dbReference type="OMA" id="LMAGHWV"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="9">
        <location>
            <begin position="2"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU43416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="286" mass="29914" checksum="82CB3BEB5E027AD6" modified="2009-10-13" version="1">MPLVGGHEGAGVVVARGELVKDIEIGDHVGIKWLHGSCMSCEQCRQSNESLCSTASLSGYTVDGSFQQYAVGKAAHVARIPKDCDLAGVAPILCAGLTVYKALKSSGVRPGQHVAIAGAGGGLGVFAIQYAKAMGLHVTALDGGDEKRKVCLELGADTFVDFRTSKDTVADIRAASGGSGPDAVLLLAASEKPFQEASQYVKSKGTIVCVGLPANAFIKAPVFDTVINIKGSYVGNRQDTAEAIEFFRQGFIKAPFKVVGLSELQDVYDLMQKGGIAGRYVVDTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7YY07</accession>
    <name>C7YY07_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_45204</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049398.1">
        <property type="nucleotide sequence ID" value="XM_003049352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YY07"/>
    <dbReference type="GeneID" id="9677034"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45204"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45204"/>
    <dbReference type="eggNOG" id="ENOG502T73B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_0_3_1"/>
    <dbReference type="InParanoid" id="C7YY07"/>
    <dbReference type="OrthoDB" id="2496787at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="25"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU43685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="338" mass="37567" checksum="184CC5540BFF1368" modified="2009-10-13" version="1">MVDYSPNIIASFCITFPIATLVVILRLISKRMTTTGYGLEDILAVCSWVGSKFTVLLRCYIGLADYGLGRPIEQGLSSQLTLDEKTKVSWLILWCSSILYSFTIAFCKFSILCFYWRLFKYSSVRIPVQVLSGLTLAWFILRLFLVTLQCIPIQGLWDHSVKHSCGVNETVFFFTTVLTHVLIDCAILALPIIEVGKMHLPKGQKIAVITLFLFGALVCLASVFVLVESLKFDSRSKEITLEMGVHSSAAVAEVNLAVISTSLPLLRPICRRMVPGFSFSSKNYHQSEQSPREVVLEDWATKPSAVARTSHHDIQPLGLLTDEIQGEPSHLSAEGSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7YY13</accession>
    <name>C7YY13_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_7302</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049143.1">
        <property type="nucleotide sequence ID" value="XM_003049097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YY13"/>
    <dbReference type="GeneID" id="9666534"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_7302"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_7302"/>
    <dbReference type="eggNOG" id="ENOG502S7CY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044876_0_1_1"/>
    <dbReference type="InParanoid" id="C7YY13"/>
    <dbReference type="OMA" id="ICAFIMD"/>
    <dbReference type="OrthoDB" id="10000533at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="4"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU43430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="258" mass="28696" checksum="E92071BFDCEC7DA9" modified="2009-10-13" version="1" fragment="single">MPVVVVAGGSGDLGGLIVKALFDTGKHEVYVLSRADSPERASPLTGKSYVPFIHTDYSSTDVLAEGLDMRRVEVVICAFSLRNESACNAQLQLIQAANKASSVRRFIPSEFNIDYDLGDAVPYSNKRFHLAGRRALEKTSLEFSYIYPGMFMDYYGMPKFPTPLRPLCFLIDPVNQVAVLPDDGEAKMSMSLTTDVAHYTALALDLEKWPRVMTTTASTVTLKSLVHLFEKYTGQPFLVEYQPVSKFLEHESLLLPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7YY65</accession>
    <name>C7YY65_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycoside hydrolase family 5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_46782</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048851.1">
        <property type="nucleotide sequence ID" value="XM_003048805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YY65"/>
    <dbReference type="GeneID" id="9667786"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_46782"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_46782"/>
    <dbReference type="eggNOG" id="ENOG502RDG8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031875_1_1_1"/>
    <dbReference type="InParanoid" id="C7YY65"/>
    <dbReference type="OMA" id="RYMVLKD"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000130">
        <property type="entry name" value="Endoglucanase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF13">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="74"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU43138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="464" mass="53882" checksum="50E68699A5BAB6DE" modified="2009-10-13" version="1">MSSGYLKVRGNEIVDQDGNVVVLRGTSLGGWLNMENFLTGYPGTESFTRAAMLEVMGKEKYDFFFDRFLYHFFTEDDAKFLQSFGLNSIRLPFSYKHFEDDMNPRQLKEEGFKHLDRVIDLCSSNGIYTILDMHTVPGCQNQDWHSDNHTSYAAFWDFKDHQDRTVWLWEALARRYKDNPWVAGFNLLNEPADSQQTRVAEFYDRLERAIRAIDPNHILFLDGNTYAMEWKGFKEILPNSIYAVHDYSMMGFPSGPRYKGTAEQKAKLKQQFSRKIEFHRSHNVPIWNGEFGAVYETEGPEADEKNEERYQLLGEQLRVYEEARISWAIWTYKGVGIMDMIHTSPESPWGKLTKSFMERKKHLQVDSMTGFPSEEVDSLIDPLVAWINKVSPSATKTYPSNWNTRAHVIRNILQTFLASSLCGEFAELFRGKSEQELEELAQSFSFKNCVHREGLNKVLSSWVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZF6</accession>
    <name>C7YZF6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adhesin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_47830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048307.1">
        <property type="nucleotide sequence ID" value="XM_003048261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZF6"/>
    <dbReference type="STRING" id="660122.C7YZF6"/>
    <dbReference type="GeneID" id="9667758"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_47830"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_47830"/>
    <dbReference type="eggNOG" id="ENOG502S7KB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019703_0_0_1"/>
    <dbReference type="InParanoid" id="C7YZF6"/>
    <dbReference type="OMA" id="CIQIRIT"/>
    <dbReference type="OrthoDB" id="3539644at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU42594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="66941" checksum="8008B499D4A96602" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZJ1</accession>
    <name>C7YZJ1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Late sexual development protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_47297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048522.1">
        <property type="nucleotide sequence ID" value="XM_003048476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZJ1"/>
    <dbReference type="GeneID" id="9667406"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_47297"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_47297"/>
    <dbReference type="eggNOG" id="ENOG502SM3U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045147_0_0_1"/>
    <dbReference type="InParanoid" id="C7YZJ1"/>
    <dbReference type="OMA" id="IKPCEYK"/>
    <dbReference type="OrthoDB" id="5293813at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002986684" description="Late sexual development protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="39911" checksum="260A5A4B248CDAD5" modified="2009-10-13" version="1">MRFSTLFAAAGIVGSAVAGALPRGFSIPSGNGFPNPNAQQEQKISLQAGGKLPGGPLPTQLGPGSTIAFQLIAFNELFETAFFSSLLYNISNSVKGFEVPKDKRYEAENVIKTVLAQEEQHAIGALATLKSANKFAPSPCKYKFPTSNLKDAISLAETFTAVVLGVLQDANVIFSKEGLPEVVRLISAVIGQEGEQNGFYRLYLDQIPSESPFLTTVPAAFAWSALQGFVVPGSCPEDIKQIKLPIFPPLLVNGGAIAKIKAKDQTLSFEATLKVTKAAEKVIAYKAKTGGLYITYQTGLQLPKSVKAENVRWVGNTIKLQAKFPFNELVAGGFTHAALTTSNNFQSVDDIPAHTLAAPGLIQVQEPISGKGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZL1</accession>
    <name>C7YZL1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">NECHADRAFT_101400</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048337.1">
        <property type="nucleotide sequence ID" value="XM_003048291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZL1"/>
    <dbReference type="MEROPS" id="A01.077"/>
    <dbReference type="GeneID" id="9667414"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101400"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101400"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_10_1_1"/>
    <dbReference type="InParanoid" id="C7YZL1"/>
    <dbReference type="OMA" id="AASNTWV"/>
    <dbReference type="OrthoDB" id="660550at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000085">
        <property type="entry name" value="Aspartic-type endopeptidase (CtsD), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000060">
        <property type="entry name" value="Aspartic-type endopeptidase ctsD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF75">
        <property type="entry name" value="ENDOPEPTIDASE (CTSD), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988690" description="Peptidase A1 domain-containing protein" evidence="14">
        <location>
            <begin position="20"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="15">
        <location>
            <begin position="124"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="434"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="443"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="155"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="358"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEU42624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="531" mass="56939" checksum="2381F7291385AAF7" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZN9</accession>
    <name>C7YZN9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_95779</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23052"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048354.1">
        <property type="nucleotide sequence ID" value="XM_003048308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZN9"/>
    <dbReference type="STRING" id="660122.C7YZN9"/>
    <dbReference type="GeneID" id="9667622"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95779"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95779"/>
    <dbReference type="eggNOG" id="KOG0787">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023861_5_1_1"/>
    <dbReference type="InParanoid" id="C7YZN9"/>
    <dbReference type="OMA" id="NEMPSIC"/>
    <dbReference type="OrthoDB" id="241648at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16929">
        <property type="entry name" value="HATPase_PDK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000065">
        <property type="entry name" value="[Pyruvate dehydrogenase (Acetyl-transferring)] kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF3">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="275"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU42641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="409" mass="46302" checksum="B56C2EA2F7D5DFEE" modified="2009-10-13" version="1">MSWKASERLMDTIRHYARFPATGVSLRQMVQFGEKPSVGTLFRASQFLAEELPIRLAHRVQELDELPDGLNEMPSVIKVKDWYAQSFEAFRLPPATPNPSIDEGESSGWGGLQNGNGNGKKAVTRRYFAVVDDTGDWPADLHLYNQRFAQTLHDIKRRHDGVVTTMAQGILEYKRRRQRMQIDSTIQSFLDRFYMSRIGIRMLIGQHIALTDQSHHRDPTYVGIICTKTNVQDLAQEAIENARFVCEDHYGLFEAPKVQLVCNPSLNFMYVPGHLSHMLFETLKNSLRAVVETHGMDKQAFPVTKVIVAEGKEDITIKISDEGGGIPRSAIPLVWTYMYTTVDRTPSLDPDFDKSDFKAPMAGFGYGLPISRLYARYFGGDLKLISMEGYGTDVYLHLNRLSSSSEPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZU4</accession>
    <name>C7YZU4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_84147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048571.1">
        <property type="nucleotide sequence ID" value="XM_003048525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZU4"/>
    <dbReference type="STRING" id="660122.C7YZU4"/>
    <dbReference type="GeneID" id="9667648"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84147"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84147"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_4_1"/>
    <dbReference type="InParanoid" id="C7YZU4"/>
    <dbReference type="OMA" id="CLLHSCE"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF61">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="357" mass="39191" checksum="92AF591DE66129FD" modified="2009-10-13" version="1">MTFWNFVRAQWTYLPLVPTEATVTGGTYIVTGANTGLGFECAKTLAKLGAKTIVLGVRSIEKGDVAAAAIAKETGREGVCQVWHLDLASLDSVEEFAKKLQTLDRIDALIQNASVALADFTLSQGVETTITVNVLSTMLLAIRAMPKLQESARTFSINPHLVIVSSVTGFQCEGVLEKHSGDLFEALSTKEADMVGRYPLSKLLQIYATRHLASLLPLSETGVIINILNPGLCKTELNRNARGFMKYQILILRLFLGRTPEQGSRTLLHAAVAGTESHGKYVSDCEIKEYLAPGWVSGESGLHMQRRVWTDLLKNLNARDVENPLLLLHPRVNAARHLCERPFPNGLKHVKVEHGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1I5</accession>
    <name>C7Z1I5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_72372</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU42011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047724.1">
        <property type="nucleotide sequence ID" value="XM_003047678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1I5"/>
    <dbReference type="STRING" id="660122.C7Z1I5"/>
    <dbReference type="GeneID" id="9671672"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_72372"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_72372"/>
    <dbReference type="eggNOG" id="ENOG502S146">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050438_7_1_1"/>
    <dbReference type="InParanoid" id="C7Z1I5"/>
    <dbReference type="OMA" id="RAKEECQ"/>
    <dbReference type="OrthoDB" id="6159137at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="74"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="130"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="220"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU42011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="333" mass="37555" checksum="20B05CBF47C6841B" modified="2009-10-13" version="1">MATTAMDYEAANGDRYEDEAPRYERDNRSASPRPRDDNEGSRRRSASPGGHGDSNMKDVSAPRDDDDGAVNPGSNLFVTGIHPKLTEAEVSKMFEKYGDVEKCQIMRDPHTKESRGFGFVKMVTSEQAEAAKEGLQGEQIEGRTLSIEKARRARPRTPTPGKYFGPPKREPRPRYDDRRRGGYGGGGGYGRDDQYRYRGYERNYERRYEERSGGGNYGGRDYDRGYREERRYEDRAGGYGGRDYDRGYERRERDEGYGRDRYAGREDRDRYGPRGGAPAGGSSGGYERERYDRQGDRDAPRTRDPAASAGAAGYSESASRSETRDAYGGSGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1M5</accession>
    <name>C7Z1M5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_64151</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU41852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047565.1">
        <property type="nucleotide sequence ID" value="XM_003047519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1M5"/>
    <dbReference type="STRING" id="660122.C7Z1M5"/>
    <dbReference type="GeneID" id="9671700"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_64151"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_64151"/>
    <dbReference type="eggNOG" id="KOG1158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_17_5_1"/>
    <dbReference type="InParanoid" id="C7Z1M5"/>
    <dbReference type="OMA" id="LCCGGGC"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030586">
        <property type="term" value="F:[methionine synthase] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050667">
        <property type="term" value="P:homocysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="FAD binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000007">
        <property type="entry name" value="Methionine synthase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF84">
        <property type="entry name" value="METHIONINE SYNTHASE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="7">
        <location>
            <begin position="196"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU41852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="615" mass="68416" checksum="56E3869922350FAC" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1N1</accession>
    <name>C7Z1N1_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_51012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU41856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047569.1">
        <property type="nucleotide sequence ID" value="XM_003047523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1N1"/>
    <dbReference type="GeneID" id="9671525"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51012"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51012"/>
    <dbReference type="eggNOG" id="ENOG502SKZZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024652_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z1N1"/>
    <dbReference type="OMA" id="WEDEGCV"/>
    <dbReference type="OrthoDB" id="3902588at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU41856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="564" mass="63602" checksum="589768FF3CA3AF3C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1R6</accession>
    <name>C7Z1R6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_50572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
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                <person name="Temporini E."/>
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            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU41870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003047537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1R6"/>
    <dbReference type="GeneID" id="9671546"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_50572"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_50572"/>
    <dbReference type="eggNOG" id="ENOG502T154">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076163_1_1_1"/>
    <dbReference type="InParanoid" id="C7Z1R6"/>
    <dbReference type="OMA" id="EHGILFC"/>
    <dbReference type="OrthoDB" id="5289641at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39697:SF2">
        <property type="entry name" value="CYANOVIRIN-N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39697">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU41870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="156" mass="17551" checksum="E9ABB1E207D7E4B2" modified="2009-10-13" version="1">MASTVDGCPTPTHTSATEMGIDNPLPVESVPSPDAVFVIRHRETGKVITLIDGELRLCEGFSARGGFHWHCVEKDRWLGFRNCVSGTYIGHNERKQFIARVSHHRPHEFFTIRPHPQGGYELLMRHNNELWSMDVGGDGLLVETKGEGALWDFLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z237</accession>
    <name>C7Z237_FUSV7</name>
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        <recommendedName>
            <fullName evidence="6">Ubiquitination network signaling protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">NECHADRAFT_105548</name>
    </gene>
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        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU41933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047646.1">
        <property type="nucleotide sequence ID" value="XM_003047600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z237"/>
    <dbReference type="STRING" id="660122.C7Z237"/>
    <dbReference type="GeneID" id="9671781"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_105548"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_105548"/>
    <dbReference type="eggNOG" id="ENOG502QSPS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005822_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z237"/>
    <dbReference type="OMA" id="NNAFWQP"/>
    <dbReference type="OrthoDB" id="4158994at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="153"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="343"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="465"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="562"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="851"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="593"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="868"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU41933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="924" mass="101479" checksum="32EE965F7FAD7A3B" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z239</accession>
    <name>C7Z239_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_86014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698906">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003047601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z239"/>
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    <dbReference type="KEGG" id="nhe:NECHADRAFT_86014"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86014"/>
    <dbReference type="HOGENOM" id="CLU_1489382_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z239"/>
    <dbReference type="OMA" id="CRMMYER"/>
    <dbReference type="OrthoDB" id="5102879at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU41934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="181" mass="21096" checksum="9EF45C9F9D7A4B8E" modified="2009-10-13" version="1">MSRARKTKNPKRRRRKRKKRLLREYCARIDQQAAQTGGAEQDGAEPSTTALPSDKDAPGPKTASTADQKTSSSESKQRFKPRKVPDRDYYPRPGKMERQYLGFQRRVTALIDEKIAKGSATLDKWKRDAGAFMEEFQRKEKIQREELELDLGRMRVNHREMLDMQARQIGRLKKKFEEING</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z292</accession>
    <name>C7Z292_FUSV7</name>
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        <recommendedName>
            <fullName evidence="4">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_72575</name>
    </gene>
    <organism evidence="5 6">
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        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU42133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003047800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z292"/>
    <dbReference type="FunCoup" id="C7Z292">
        <property type="interactions" value="396"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z292"/>
    <dbReference type="GeneID" id="9671809"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_72575"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_72575"/>
    <dbReference type="eggNOG" id="KOG3771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072096_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z292"/>
    <dbReference type="OMA" id="TRFCAYF"/>
    <dbReference type="OrthoDB" id="446293at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07591">
        <property type="entry name" value="BAR_Rvs161p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000014">
        <property type="entry name" value="Protein hob3, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037429">
        <property type="entry name" value="Rvs161/Hob3_BAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01251">
        <property type="entry name" value="AMPHIPHYSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="4">
        <location>
            <begin position="17"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU42133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="261" mass="29843" checksum="997B62C428A15CD2" modified="2009-10-13" version="1">MSWAGFKKNVNRATTQVMMKTGHVEKTNDRDYEVEERRFKTMEAAALRLQKESKGYLDSLRAMTASQMRIAETIDAFYGDSGAKDGVSRSYKQAVEDLDAETIKALDGPYRTTVLDPISRFCAYFPDVNEAIKKRSHKLLDYDALRAKVKRLAEKPDKDATKLPRTEKEMEMAKAAYEQLNEQLSSELPQLIDLRVPYLDPSFEALVKIQLRFCAEAYSRMAQVQQYLDADTRDQYAEGQLDARVEQVLQEIRELSISGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z2C8</accession>
    <name>C7Z2C8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_50720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU41980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047693.1">
        <property type="nucleotide sequence ID" value="XM_003047647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z2C8"/>
    <dbReference type="STRING" id="660122.C7Z2C8"/>
    <dbReference type="GeneID" id="9671648"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_50720"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_50720"/>
    <dbReference type="eggNOG" id="KOG1535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_436837_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z2C8"/>
    <dbReference type="OMA" id="DHKQFFL"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="81"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="346"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU41980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="590" mass="62352" checksum="C8840E662567567E" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z355</accession>
    <name>C7Z355_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_54076</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047314.1">
        <property type="nucleotide sequence ID" value="XM_003047268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z355"/>
    <dbReference type="GeneID" id="9675917"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_54076"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_54076"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_4_4_1"/>
    <dbReference type="InParanoid" id="C7Z355"/>
    <dbReference type="OMA" id="WMNTYFN"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000386">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="70"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU41601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="505" mass="56411" checksum="027419ABDB26F625" modified="2009-10-13" version="1">MAPHAVEGDNAISTANASAKNRSSITSAAAVDLKNDTTVPAAGKDQWFHWHEPGTSKEEKKLIFKLDWFLLSFACLLFFIKQLDGNNVSNAYVSGMSEELGFGPGNELSWMNTYFSIGTIIGGTAANLIITVLRPRIWLSSCLLIWSVFVLALFKCNHAYQFYVLRFFIGLFESAAWPGVMYCLGSWYRKSELSRRSGLFVMSGVIGQMFSGYLQAALFTGMHGKGGMSAWRWLFIFDFILALPVAVYGFFCFPDTPHTTTAFYLNEWEKERSKQRIEEEGRKPAGKMDWSVLRRVFGSWQVYSFTAAYSFWTLTCGSYVMQYFAIYLKSTGWYSVPEINNIPTCIGAVNFVFMISTGYIADKLGGRALVCGAVGSLMIFNYAILTAWDVPHKLRMAVFIIHGCYGCFTPLLAGWANEACGGDQQKRAFILGFMVSVGQAVVIPFQQVQLASGEAPEFKKTHGWGSALAWVVALTLWTGVGLPLVQRWRQKEVVVTTREEDVDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z3D4</accession>
    <name>C7Z3D4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_53778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047348.1">
        <property type="nucleotide sequence ID" value="XM_003047302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z3D4"/>
    <dbReference type="STRING" id="660122.C7Z3D4"/>
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    <dbReference type="KEGG" id="nhe:NECHADRAFT_53778"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_53778"/>
    <dbReference type="eggNOG" id="ENOG502SPY5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_763099_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z3D4"/>
    <dbReference type="OMA" id="IYCPRYH"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU41635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="363" mass="41392" checksum="7DDA0E80B44A385F" modified="2009-10-13" version="1">MSPQVTSVVLDRKYWEGNSKYFFKTIPPRVSKYAQRADDACIQTQIDVFGRDNVGIIQGSLGSAANFAATIYAESLPDRLPILAYLNEVLSFYEAFEEEMAEMMEATIDFPVPKDPKFNNPEWQANFRHVLPKIAKIISMADQNLGPKTIQAMKELTETPNLSPRMPHYKTMDEYLAERIDDIAWPSVFACAEFGANLNLTTKQKESVDAVFRPLWIHSCCVYDYYTWEKELGIAASHGEGRNIINGIALLGRLEGFSINDAKEWLNRKCFECEEEYLGLKKGYLSKNPSESLPEDMRKWFDCQEAIATGFAIWCATTYRHHPPHQKGYVDYYEKRLGEGALWFDTAEDSEDLMPGGFEAGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z491</accession>
    <name>C7Z491_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CLP1</name>
        <name evidence="13" type="ORF">NECHADRAFT_95340</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Polynucleotide 5'-kinase involved in rRNA processing.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of a pre-mRNA cleavage factor complex. Interacts directly with PCF11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Clp1 family. Clp1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046986.1">
        <property type="nucleotide sequence ID" value="XM_003046940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z491"/>
    <dbReference type="FunCoup" id="C7Z491">
        <property type="interactions" value="813"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z491"/>
    <dbReference type="GeneID" id="9675322"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95340"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95340"/>
    <dbReference type="eggNOG" id="KOG2749">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018195_3_1_1"/>
    <dbReference type="InParanoid" id="C7Z491"/>
    <dbReference type="OMA" id="VQYVNCH"/>
    <dbReference type="OrthoDB" id="258143at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="entry name" value="Clp1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.330">
        <property type="entry name" value="Pre-mRNA cleavage complex subunit Clp1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03035">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028606">
        <property type="entry name" value="Clp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010655">
        <property type="entry name" value="Clp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038238">
        <property type="entry name" value="Clp1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF6">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06807">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp1 N-terminal" evidence="11">
        <location>
            <begin position="23"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="12">
        <location>
            <begin position="131"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 C-terminal" evidence="10">
        <location>
            <begin position="345"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="134"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU41273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="451" mass="49089" checksum="E78293C27B99DFB5" modified="2009-10-13" version="1">MSIPGLGQIPSQPTASSTRVLALRPVCEWRFQVSHGSSVIVKVLSGTAEKDGVELAPRNAYIFSGVKSKILTWHGCELEIDGRCDSESIADYGNPTENVANSHLNLHGQLNDMRQAAAREGREGPRVLITGGVNTGKTTLARTLTSYATRQGYQPLVVNADPKEGLLSLPGTLSASVLATIMDPEAVDGWGSTPTSGPSSVPVKLPLVFYYGLESPEEDPDFYRELVSKLAGSVSGRLNEDENVKSSGVIIDGTGLPEQTKDGFDLISHIVDEFSINVVIVVGSSHISGELTKRFGSERTSLGEPISVVPMDKSDGVVERDEMFMQHAREAAIKEYFFGDSRRTLSPLIQQVDFDNVVVYHTPEQPTYNGETLAREEPSTPMQHWTLAIMHATPKESPDTVRAAGVMGFLYVSDVDEERRKIKLLSPVSGRLGDQPLVWGKWPEPYINLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4D8</accession>
    <name>C7Z4D8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Bms1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_34147</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. BMS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046045.1">
        <property type="nucleotide sequence ID" value="XM_003045999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4D8"/>
    <dbReference type="FunCoup" id="C7Z4D8">
        <property type="interactions" value="1413"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z4D8"/>
    <dbReference type="GeneID" id="9678097"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_34147"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_34147"/>
    <dbReference type="eggNOG" id="KOG1951">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002486_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z4D8"/>
    <dbReference type="OMA" id="KLHVPMV"/>
    <dbReference type="OrthoDB" id="10260897at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000232">
        <property type="term" value="P:regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01882">
        <property type="entry name" value="BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000105">
        <property type="entry name" value="BMS1 ribosome biogenesis factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037875">
        <property type="entry name" value="Bms1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF2">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BMS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="12">
        <location>
            <begin position="66"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="397"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="544"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="615"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1084"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="424"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="454"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="470"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="489"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="554"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="571"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="621"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="671"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1091"/>
            <end position="1123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU40332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1142" mass="130450" checksum="C07535C30E2DCCDC" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4F7</accession>
    <name>C7Z4F7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_66509</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046052.1">
        <property type="nucleotide sequence ID" value="XM_003046006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4F7"/>
    <dbReference type="GeneID" id="9668414"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_66509"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_66509"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z4F7"/>
    <dbReference type="OMA" id="ENRFRFP"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000059">
        <property type="entry name" value="N-ethylmaleimide reductase, FMN-linked"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="5">
        <location>
            <begin position="8"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU40339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="375" mass="40960" checksum="BA1F558BC0B80D50" modified="2009-10-13" version="1">MTVSKTTKLFTPIKVGAFNLQHRVVLAPLTRRRADAATAVPAEWAAEYYAQRSTPGGLLVSEGTFIAEEAGGLTHVPGIYSKDQIAAWKDITDAVHAKGGIIFCQIWALGRAARPNVVSTVWSAGSKPLIQEGAASSDPPPNFKVLSESDIDRFVGHYRQAALNAVEAGFDGVEIHGANGYLVDQFLQSNTNDRTDSYGGSIENRLRFPLRVLNAVSDAIGPERVGIRMSPFSRFQGMREADPLALFVPWAKAIVKAQPSLAFVHAVEPRADGSSDTPEHLRRAEDTLAPIREVLDSAGIKLIVAGGFLPETAIKHASETDDLVAFGRYFIPNPDLPARIENGWPLTKYDRSLFYTQNEVGYTDYPPYNDNEPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4N8</accession>
    <name>C7Z4N8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylglycerol/phosphatidylinositol transfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_66557</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046094.1">
        <property type="nucleotide sequence ID" value="XM_003046048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4N8"/>
    <dbReference type="FunCoup" id="C7Z4N8">
        <property type="interactions" value="123"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z4N8"/>
    <dbReference type="GeneID" id="9678473"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_66557"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_66557"/>
    <dbReference type="eggNOG" id="KOG4680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097982_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z4N8"/>
    <dbReference type="OMA" id="HQTYDLC"/>
    <dbReference type="OrthoDB" id="6409159at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00917">
        <property type="entry name" value="PG-PI_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.770:FF:000004">
        <property type="entry name" value="Phosphatidylglycerol/phosphatidylinositol transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033917">
        <property type="entry name" value="ML_PG-PI_TP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF0">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL_PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988480" description="Phosphatidylglycerol/phosphatidylinositol transfer protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="9">
        <location>
            <begin position="44"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU40381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="180" mass="19103" checksum="02AF364060575DFE" modified="2009-10-13" version="1">MRFSTVTACLTACLAPAAALSVLNGRAPDVTINDDLKIPGDSPLELCPGDHAADLIKIDSVDLLPNPPQAGQELVIKAKGTVKQKIEEGAYVLLTVKYGLIRLISTKADLCEQIGNVDLKCPVEAGDLEILKTVDLPAEIPPGKYTVLADVFTVEDVQITCLTATVEFSRSSKGLFGLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6S8</accession>
    <name>C7Z6S8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_90822</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045894.1">
        <property type="nucleotide sequence ID" value="XM_003045848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6S8"/>
    <dbReference type="FunCoup" id="C7Z6S8">
        <property type="interactions" value="1056"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z6S8"/>
    <dbReference type="GeneID" id="9668097"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90822"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90822"/>
    <dbReference type="eggNOG" id="KOG2274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008920_1_1_1"/>
    <dbReference type="InParanoid" id="C7Z6S8"/>
    <dbReference type="OMA" id="NPDQYTI"/>
    <dbReference type="OrthoDB" id="431626at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056840">
        <property type="entry name" value="HEAT_IPO9_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF9">
        <property type="entry name" value="IMPORTIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25018">
        <property type="entry name" value="HEAT_IPO9_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="23"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU40181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1062" mass="117828" checksum="908AB4970674D4B2" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6U7</accession>
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        <recommendedName>
            <fullName evidence="3">Calcium channel YVC1-like C-terminal transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_99148</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="660122.C7Z6U7"/>
    <dbReference type="GeneID" id="9668108"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_99148"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_99148"/>
    <dbReference type="eggNOG" id="KOG3609">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="C7Z6U7"/>
    <dbReference type="OMA" id="GYACEFV"/>
    <dbReference type="OrthoDB" id="310870at2759"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF5">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
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            <end position="587"/>
        </location>
    </feature>
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        <location>
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            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="697"/>
        </location>
    </feature>
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        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="625"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU40760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="697" mass="78830" checksum="CBA91E8B06BD63DA" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
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    <name>C7Z9B8_FUSV7</name>
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        <recommendedName>
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        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">NECHADRAFT_94442</name>
    </gene>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreales</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003045143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9B8"/>
    <dbReference type="FunCoup" id="C7Z9B8">
        <property type="interactions" value="416"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z9B8"/>
    <dbReference type="GeneID" id="9673769"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94442"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94442"/>
    <dbReference type="eggNOG" id="KOG3077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047042_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z9B8"/>
    <dbReference type="OMA" id="LWCKFLQ"/>
    <dbReference type="OrthoDB" id="27198at2759"/>
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        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DCN-prot"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF31">
        <property type="entry name" value="DCN1-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DCUN1" evidence="3">
        <location>
            <begin position="106"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU39476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="323" mass="36169" checksum="747875CEDA7E058B" modified="2009-10-13" version="1">MPPPSSAQQKVLIAQFVSLTGATERQATRFLKNASFKINEAVDTPNMNWEGVKRRIATRVIPTLSLSKKSSKVGLGTSYKGSPAETSNKSKARYFSSDGNGKGPSPVEAKLESLFDQLQDSNDEKDKLELDSTMAYLTEKLKINIENAELLVVLELLQAPSVGMITRRGYVDGWKNTGAGATHQEHAAHLRRLISSLSSDPTLFKKVYRYAFVAGREPDQKALGLENALVYWDILFASPGMEWKTANRDWLDLWKSFLNAKWTRSVNKDMWNMTLEFAVKSLSDESLSFWNEDGAWPSVIDDFVEWCREKGIGKADGMDVDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9D0</accession>
    <name>C7Z9D0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_81712</name>
    </gene>
    <organism evidence="4 5">
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045196.1">
        <property type="nucleotide sequence ID" value="XM_003045150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9D0"/>
    <dbReference type="GeneID" id="9673774"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_81712"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_81712"/>
    <dbReference type="eggNOG" id="ENOG502SJNF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024934_9_2_1"/>
    <dbReference type="InParanoid" id="C7Z9D0"/>
    <dbReference type="OMA" id="CGNCKIR"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU39483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="448" mass="49544" checksum="9713012CAB8EDF17" modified="2009-10-13" version="1">MVVAGEANKKTPPVRQRKAHRKSRLGCSNCKLRSVKCDESKPSCKRCISSGFICSFTQTSPSASLHLAHCSAGPVFSVAADPATDQILKAPLPGLRVPVAQPTRGAVGEIILGEAEMAALERFRLRTVFTMGTEKTRHLYAERAVKLAYKHPFLIHAFIAFALLHDGHITPKQPPSHRTALAFHWYQATVLFQQRLLAAHSTPDLSLLPSSERDAIWTASVLLGASALALVDVQNVEGAWPLKVPDILDLDWLKMSEGKKVAWALADPTRAESIFHELLLHKDQMPNGAKPIPPGALPPSFFTTFNLSPASSPISNPYHVAASLLAQLLPQKINDNSVVQFLAFLTQLDPRYKQLLEDKDPRAIVLLTWWYAKAAAHSSWYMQRRSLVEGQAICIYLERYCMDVPGISELVQFPKRVFGFSCKNGGIMNLGDVRTLREGGRSNIWMKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9N4</accession>
    <name>C7Z9N4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_14395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044844.1">
        <property type="nucleotide sequence ID" value="XM_003044798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9N4"/>
    <dbReference type="STRING" id="660122.C7Z9N4"/>
    <dbReference type="GeneID" id="9673829"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_14395"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_14395"/>
    <dbReference type="eggNOG" id="ENOG502S38Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023951_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z9N4"/>
    <dbReference type="OMA" id="IQMQTYR"/>
    <dbReference type="OrthoDB" id="4181307at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034443">
        <property type="entry name" value="PB1A10.08"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42051">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED PROTEIN PB1A10.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42051:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED PROTEIN PB1A10.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="423" mass="47322" checksum="3508860039551360" modified="2009-10-13" version="1" fragment="single">PTSPVKIPSASNNRHGTHPQKRHTSQRRRTRDSRSSEIMSPSLAALLAVTDIPRPRQLQRRRRTEKTLTVEEVIDCQQASEKELSWSFSRSPLDMLLSPPHEIADDDDSVSDCNIGSAMSIRTYSVDSIPSLDESFSSDCLSSLDSPRTPSICSRRTRFTPMRKSLEPVISPPGSVDEHPLAGDDADVDEMDIITLEQPEEVQPSKLQFLQPFKPLRSVFKSNLTASLRALRSAAKSFSGINLPSIPPDDFLTRSILTIDPNVPYADERRPPVSEEMPSAAMRRYLNPTTNARIESPTKTVFAGTFAASIQMRTYKIQRSRTAPGSFRNAYPSTSLQSQPSPAPQQPQPQAPTQTPPGMRQREMRENPDFIRIAVMEMAMRKRGKLDDQKPGRARWALPPRQMSTKPYEVAPSGVPVRWIPIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZB53</accession>
    <name>C7ZB53_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_45816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044589.1">
        <property type="nucleotide sequence ID" value="XM_003044543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZB53"/>
    <dbReference type="GeneID" id="9670783"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45816"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45816"/>
    <dbReference type="eggNOG" id="ENOG502SBBY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084522_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZB53"/>
    <dbReference type="OMA" id="HYHSITH"/>
    <dbReference type="OrthoDB" id="2446447at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd02219">
        <property type="entry name" value="cupin_YjlB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047121">
        <property type="entry name" value="YjiB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448">
        <property type="entry name" value="BLR7373 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448:SF2">
        <property type="entry name" value="CUPIN TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU38876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="21837" checksum="55128213D2F5ECE8" modified="2009-10-13" version="1">MTAIAPPEQYVLPATKYCPNNKMPVLIYRNVLPRPRTEKSAQEWIEKNGWLRAGIVWPAVYRRHFHPNVHECYAILSGSSEVLMGVGKLDEAETPESEASSQLGLLLTLREGDVIVHPAGTGHSNVSDEGRYRYLSFFPEGSPKWMSENGDKPLRDNEDMWQLIKNVPMPQDPVTGGEGHLTQAWRTGSVENAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBC3</accession>
    <name>C7ZBC3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">trans-L-3-hydroxyproline dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.77</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_83096</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>trans-3-hydroxy-L-proline = 1-pyrroline-2-carboxylate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10320"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:39785"/>
            <dbReference type="ChEBI" id="CHEBI:57938"/>
            <dbReference type="EC" id="4.2.1.77"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the proline racemase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.77" evidence="3"/>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044531.1">
        <property type="nucleotide sequence ID" value="XM_003044485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBC3"/>
    <dbReference type="STRING" id="660122.C7ZBC3"/>
    <dbReference type="GeneID" id="9670828"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83096"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83096"/>
    <dbReference type="eggNOG" id="ENOG502QRPF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036729_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZBC3"/>
    <dbReference type="OMA" id="WIKSEDW"/>
    <dbReference type="OrthoDB" id="6409228at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050346">
        <property type="term" value="F:trans-L-3-hydroxyproline dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008794">
        <property type="entry name" value="Pro_racemase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33442">
        <property type="entry name" value="TRANS-3-HYDROXY-L-PROLINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33442:SF1">
        <property type="entry name" value="TRANS-3-HYDROXY-L-PROLINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05544">
        <property type="entry name" value="Pro_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00028">
        <property type="entry name" value="Proline_Racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU38818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="345" mass="37773" checksum="EFC6FD751FC1F40A" modified="2009-10-13" version="1">MADNSSYWVESEDWHTAGEPFRIIQHPPSGLLPNVQTVSERYLEITKTKDHPLDRLRIFLSHEPRGHADMYGGFITSPNDSTSSFGVLFWHKDGFATACGHGTIALGYWAVHKGLVDAPENGVVDVIIDVPSGRVVASVTRKDGKSINADFVNVSTYQVAKSLSVTTPSRDSDVVVDLAFAGAVIASVDTSQLGLEVKPSNVNEFIRLQREIKASLGDRGEYGDNKWYAMLFFQEEENTKGPGWIVQKSVNIYGDGQVDRSPCGSGTCGRMAILLAQGRLKENSRLLHHSIIGTAFEAEIVSKGQSPVEGFPACVVRVRGEAYLVAETRFFINDEDPVSPGFVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBE1</accession>
    <name>C7ZBE1_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_23646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044538.1">
        <property type="nucleotide sequence ID" value="XM_003044492.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBE1"/>
    <dbReference type="STRING" id="660122.C7ZBE1"/>
    <dbReference type="GeneID" id="9670732"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_23646"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_23646"/>
    <dbReference type="eggNOG" id="ENOG502SJG1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026305_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZBE1"/>
    <dbReference type="OMA" id="KIWHAFN"/>
    <dbReference type="OrthoDB" id="5331891at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186:SF4">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU38825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="546" mass="62313" checksum="1981D4B5D9429BF4" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBP2</accession>
    <name>C7ZBP2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_88480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698915">
        <property type="protein sequence ID" value="EEU38601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044314.1">
        <property type="nucleotide sequence ID" value="XM_003044268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBP2"/>
    <dbReference type="GeneID" id="9670637"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88480"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88480"/>
    <dbReference type="HOGENOM" id="CLU_1825794_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZBP2"/>
    <dbReference type="OMA" id="LLWHTNN"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="141" mass="15620" checksum="3989D1023D8B0727" modified="2009-10-13" version="1">MARRWLGTISLGLMVFEVSKTDNLGSQFDIATVLLTLATIAAIANIAVITMLKFAFENHGFQPKRIDFLFLLSPLVLLDLIIVSVLTGLFLLFNSILPSWFGAIAGAQLVFFLVFMLTVSVLVWKRVRVPNETDDGKTSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZC41</accession>
    <name>C7ZC41_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_88727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698917">
        <property type="protein sequence ID" value="EEU38423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044136.1">
        <property type="nucleotide sequence ID" value="XM_003044090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZC41"/>
    <dbReference type="STRING" id="660122.C7ZC41"/>
    <dbReference type="GeneID" id="9670488"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88727"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88727"/>
    <dbReference type="HOGENOM" id="CLU_1454799_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZC41"/>
    <dbReference type="OrthoDB" id="10544258at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU38423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="186" mass="20759" checksum="003F76CF75B0CAFE" modified="2009-10-13" version="1">MYPVMLQIGAMSVYPRLFDLGADDLPVTGPLFGAYKSFATVLDILPIDFKFACSTRRYDNAARIDNGSDRSARYENSLRQTRRVTQTRRVMQLKVKTNLDHPIRPAALVCRSDEICRSVGLRFEDGLSDGLSDGRNLGTSLWSRLGYRPVQTRIPSSLSLILISRIIKLAGLLSALSLTLISLSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCC1</accession>
    <name>C7ZCC1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_91452</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698918">
        <property type="protein sequence ID" value="EEU38345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044058.1">
        <property type="nucleotide sequence ID" value="XM_003044012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCC1"/>
    <dbReference type="STRING" id="660122.C7ZCC1"/>
    <dbReference type="GeneID" id="9670469"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_91452"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_91452"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="InParanoid" id="C7ZCC1"/>
    <dbReference type="OMA" id="TGDDWNP"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF579">
        <property type="entry name" value="3-BETA HYDROXYSTEROID DEHYDROGENASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G02250)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="9"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU38345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="337" mass="37091" checksum="53DA61F8F9942F3B" modified="2009-10-13" version="1">MSLEPHKFVLVTGATGFIGAHVVDTLLERGIKVRGATRSIEKGNVMKKARPQHAANLEFVQIQDFENPGGLEEAVQGVDGVIHVASPFTYDTTDNEKELIIPAINGVRAILEACTTNRAISRLVITSSFASVVDIARKGNYAYTSKDWNPLTYEESVAPTSDAVVAYRASKKFAELEAWKFVEERKPHFDIVTLCPPMTFGPVVHPISGIDKLNESNAVLWSVAKGVSLLPVSRVPFWIDVRDLATAHVQALLVKDAGGKRFTPTAPEKFSYGLAAQLMVEEFPQLKEVIKLEEQVIDESKSLDGETAGRELGYEYRTFRQTVKDFISQAIALEKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCC5</accession>
    <name>C7ZCC5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RTA1 like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_27977</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698918">
        <property type="protein sequence ID" value="EEU38347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044060.1">
        <property type="nucleotide sequence ID" value="XM_003044014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCC5"/>
    <dbReference type="GeneID" id="9670385"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_27977"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_27977"/>
    <dbReference type="eggNOG" id="ENOG502SN5A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033465_3_1_1"/>
    <dbReference type="InParanoid" id="C7ZCC5"/>
    <dbReference type="OMA" id="EFYPYTP"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF17">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09900)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU38347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="26989" checksum="0E4D173E9FD4E315" modified="2009-10-13" version="1" fragment="single">YPYTPSKAAGFIFMALFALVTIIHIAGVRRYKTNYFIPMVLGGICETFGYYGRAWAGSKPNSPKPFMLQLMLILVAPVFICATLYVTLGRYKQVLLGQPKRKCSPTSLFILTDIIAFCTQIGGSLVQVTGSTKIMKIGDKVVLGGLLFQLLVLAIYFYLVFRFYRKACQETLFAGIWKPYVWMLGISVIAIWIRNLVRAIEFVQGFHGFISENEAMLYVMDASLMLGVMVAFLIFHPGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCE5</accession>
    <name>C7ZCE5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_77025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698918">
        <property type="protein sequence ID" value="EEU38356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044069.1">
        <property type="nucleotide sequence ID" value="XM_003044023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCE5"/>
    <dbReference type="STRING" id="660122.C7ZCE5"/>
    <dbReference type="GeneID" id="9670394"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77025"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77025"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005006_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZCE5"/>
    <dbReference type="OMA" id="AGRNTIW"/>
    <dbReference type="OrthoDB" id="5098801at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF5">
        <property type="entry name" value="DUF6590 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="788"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1130"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1130"/>
            <end position="1142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU38356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1158" mass="131948" checksum="5E57D2ACE9B83913" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZD25</accession>
    <name>C7ZD25_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_4083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698919">
        <property type="protein sequence ID" value="EEU38021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043734.1">
        <property type="nucleotide sequence ID" value="XM_003043688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZD25"/>
    <dbReference type="STRING" id="660122.C7ZD25"/>
    <dbReference type="GeneID" id="9670220"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_4083"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_4083"/>
    <dbReference type="eggNOG" id="ENOG502SH9U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022730_0_1_1"/>
    <dbReference type="InParanoid" id="C7ZD25"/>
    <dbReference type="OMA" id="YHAGQCL"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF260">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="441" mass="48402" checksum="7A7E3ED4F75616B7" modified="2009-10-13" version="1" fragment="single">LSFWQQTTRTYRHLESNRYQPVPSTSPYVVIGTGIAGGLLAYELIQAGVPGKDIVLLEAREAASGASSRNAGHVRPDAFRGFETYARHHGKEQAVKILANERIVLEKVNQFVREHNVPCDFNYTTTFECCMSPEFAEHDRRNYEAFKAAGGDVSHVRRYTGEEATNKTRIAGVLAAYEWPAGSSHPAKLAQWLLDAVIEKGAQLYTFCPAAAVTKYLGSQRDGQPQLWDIQTPRGVITTPKVVYCTNAFTGHLLPQLAPHIIPYRGQAHAIVPVPSLTGNKVLTSTYSLRYSLNHYYSIIQRQSDGTVILGCSLPNPALPKSVIEGIRTIDDTYFNDAIKQDAFTHLKALLPDAGLEKAKYGEGLVHAWNGIVGLTNDEIPFLGSVPGKPGQFVCAGFNGHGMARIFTCAPGVAQMILGKPWADTGLPECFAFDQERIDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDP8</accession>
    <name>C7ZDP8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_88210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043620.1">
        <property type="nucleotide sequence ID" value="XM_003043574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZDP8"/>
    <dbReference type="GeneID" id="9669453"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88210"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88210"/>
    <dbReference type="eggNOG" id="ENOG502R8B1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_746160_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZDP8"/>
    <dbReference type="OMA" id="CTELCIA"/>
    <dbReference type="OrthoDB" id="5103024at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002987025" description="WSC domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="29"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU37907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="371" mass="36622" checksum="D24BF39FD4971994" modified="2009-10-13" version="1">MAPTTLITSLLALTVTTILASPVPHPTSNFEYVGCVAGSPSSFPKKMPFDDSTFSAEACLEACIGQAHLVAIGGGCYCDDPEDATPMSFELVDEARCSTVCIPGDNASGKCGGDGVFSLWQLPGTEKADCKKAEVKVVVECPPEVVDCPGRAAAAPEETIPPVIPTATCPPGGCGEPIPPTPVAQAQQAAADSCPPGGCGEPVLPATPAVQKQAAANACPPEGCPPATPVPAPIPAPIPAPAATPAPANNSTPNGCPPEGCVPPPASQNPAAVLPNCEGDNCEDSNASPAENQDKASGSSAGSAGEDTGAAAEQSDASAGQSDATGEQSGSSGEDSGASGDAPALVSESPRLYSSGVLSSIVAIIFGLYLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDV4</accession>
    <name>C7ZDV4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_54715</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043469.1">
        <property type="nucleotide sequence ID" value="XM_003043423.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="nhe:NECHADRAFT_54715"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_54715"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_27_2_1"/>
    <dbReference type="InParanoid" id="C7ZDV4"/>
    <dbReference type="OMA" id="TPYIYVT"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Multidrug resistance protein D"/>
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    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF11">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="31"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU37756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="523" mass="57575" checksum="A6331E54433C7AC8" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDW1</accession>
    <name>C7ZDW1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-dehydropantoate 2-reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_64834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EEU37759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GeneID" id="9669857"/>
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    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_64834"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3609at2759"/>
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        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
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    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
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        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF30">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="2">
        <location>
            <begin position="199"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU37759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="37117" checksum="79DA16486B2F81F5" modified="2009-10-13" version="1">MAKSRVLVVGTGGIGTMSAYALENGGLAEVTAVMRSNYDAAVKDGIDIDSVQYGQIKAWRPTAITKTVPDVSKGDVAPFDFILVTTKNIPDVPPTVADIIAPAVTPGKTAIVLSQNGINIEKPLIPRFPTNPLISSVAYTGATETALAKIYNDDPDTQKIGAFVNPKVPTAVAAEAAQCYVRIYNPEGKLNVIYEPDVGKARWRKIAYNGSMNPIASILRMDTPRMRMSRHIIDDLILPIILEIRAVAGASGITLQPDLIDAIMHQDPNDTAFKPSMCQDYEKGNLMEIENLIGEPLREGEKLGVPMPTLRVVYGIMKGLQLKVKEEKGLWTAKFEPGNPYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZG37</accession>
    <name>C7ZG37_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_52094</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698924">
        <property type="protein sequence ID" value="EEU37010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042723.1">
        <property type="nucleotide sequence ID" value="XM_003042677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZG37"/>
    <dbReference type="STRING" id="660122.C7ZG37"/>
    <dbReference type="GeneID" id="9664928"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_52094"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_52094"/>
    <dbReference type="eggNOG" id="KOG2820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZG37"/>
    <dbReference type="OMA" id="WLEWNRA"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF15">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="8"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU37010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="490" mass="55074" checksum="8D532B872E262B74" modified="2009-10-13" version="1">MLSHDSEIIIVGGGVFGLSSALWLARGGYRNITIFDRCAFDKNGYDPSRGCDGASADINKVFRMAYAERTDYQDLAIEARNFWLSWNKAITEANSTDLPEGLTPEDKLFYICGSYFLAEGPELRDYYADSLKTMEKTAPEFRKMQFGNTQDEKRLGQIDSKWVEKYHIIDRINGGNTNGFIDIQGGITIADKACIYAKFLCEQVGVKFVLGNPQGKLSSLIVENDGLNKRVAGIKTCDGLRHFGDLVIVAAGSWTASIIPEAHQTVEATAGTVMFVDIPKHRQDLWKKFHPDNYPVWSYRRGEGEEHCADPHASYYQGGGFPISKEGRLKFGFRGRKFTNFQAHPTQPDLRISTPRTKYTEKRINTVPLYGLSRMKEVIAQAFPELAEFGFTDSRLCWYTDSIDNDYVIDYVPGYSDSLFICTGGSGHAFKFLPVLGKHVKNQIERVPDQFTPVWKWRVAQQGKPNNGLSEGEDGPREMSKLEMASGRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZG93</accession>
    <name>C7ZG93_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline monooxygenase, chloroplastic</fullName>
            <ecNumber evidence="5">1.14.15.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_42368</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the first step of the osmoprotectant glycine betaine synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>choline + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = betaine aldehyde hydrate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:17769"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15870"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.14.15.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (monooxygenase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the choline monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.7" evidence="5"/>
    <dbReference type="EMBL" id="GG698925">
        <property type="protein sequence ID" value="EEU36784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042497.1">
        <property type="nucleotide sequence ID" value="XM_003042451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZG93"/>
    <dbReference type="GeneID" id="9670088"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_42368"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_42368"/>
    <dbReference type="eggNOG" id="ENOG502QQJW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026244_1_2_1"/>
    <dbReference type="InParanoid" id="C7ZG93"/>
    <dbReference type="OMA" id="RVPLHYY"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="UniPathway" id="UPA00529">
        <property type="reaction ID" value="UER00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019133">
        <property type="term" value="F:choline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019285">
        <property type="term" value="P:glycine betaine biosynthetic process from choline"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00680">
        <property type="entry name" value="RHO_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03469">
        <property type="entry name" value="Rieske_RO_Alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF5">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="13">
        <location>
            <begin position="28"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU36784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="392" mass="45290" checksum="8CC799736C8EFBA5" modified="2009-10-13" version="1">MQSTLPASWYREPGFYELERRAIFSKSWILISHSCQFNEPGKYARYEMAGYPFFIIRDRAGSVNAFLNVCRHRAFPIVHEDAGKVMVLSCKYHGWSYSMNGNLAKAPRFDQVEGFQKDDYKLYKVHTHIDDLGFLWVNLDAAEKPTLSWEEQFGGVDKQPRLSNFDMSNYEYDHTWSMEGKFNWKTLIENYNECYHCPTAHPGLAPFFRNNRQMVYGCHKYWVEHLGGKGEERSSSVSPTYMFPNASVTLTPVFFYMMSIVPTSATTSLMRYEVYRAKNATKEQLQEKLDFFAQVEGEDKWLANGSQANLNNDTYTTGPFHPDVEQGVTYVTGLVKKMLHDHFDEEKKRGQEWWPARRALAQSSSEEDEAFCRGVCGHSVLNGNNAPEGLSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZGC3</accession>
    <name>C7ZGC3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_104604</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698925">
        <property type="protein sequence ID" value="EEU36890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042603.1">
        <property type="nucleotide sequence ID" value="XM_003042557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZGC3"/>
    <dbReference type="GeneID" id="9670103"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_104604"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_104604"/>
    <dbReference type="eggNOG" id="ENOG502QSKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_1_2_1"/>
    <dbReference type="InParanoid" id="C7ZGC3"/>
    <dbReference type="OMA" id="YLSKWCR"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF102">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU36890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="38945" checksum="C4A7AC5B151B3AD2" modified="2009-10-13" version="1">MPATPSPERSPSSQGGSEHHVEPTIEIEDAIAADNDSTLGEESDQSHVSLSSSIMAYREENGRRYHALSSGKYVLPNDDAENDRLDLQHELYVRTLHGELALCPKARDAKRVLDIGTGTGSWAIDYADANPEAEVIGVDLSPIQPSFVPPNLIFEIDDLEKEWTWTKKFDFIFARMMLGCFQDFPQIIKVAFDNLEPGGYLELQDMSLPARSDDDTLQPDSYLSQWCRCCFEAGQNLGRPVFPTTEYKNYLAAAGFEGIVEVQRKWPTNAWPRDKHFKELGNWTRANIAGGLDGLSLAYFTRGLGWTPEETRVFCAHTRKDMENPKIHAYWPIYFVYGRKPLTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZGE8</accession>
    <name>C7ZGE8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flavin-containing monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_94035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698925">
        <property type="protein sequence ID" value="EEU36836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042549.1">
        <property type="nucleotide sequence ID" value="XM_003042503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZGE8"/>
    <dbReference type="GeneID" id="9670136"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94035"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94035"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015676_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZGE8"/>
    <dbReference type="OMA" id="LLELNIW"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF68">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU36836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="623" mass="69138" checksum="FD7ADCC24D61C1A9" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZGF9</accession>
    <name>C7ZGF9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_81075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698925">
        <property type="protein sequence ID" value="EEU36843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042556.1">
        <property type="nucleotide sequence ID" value="XM_003042510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZGF9"/>
    <dbReference type="GeneID" id="9670140"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_81075"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_81075"/>
    <dbReference type="eggNOG" id="ENOG502RN1W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_364494_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZGF9"/>
    <dbReference type="OrthoDB" id="5125733at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="236"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU36843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="766" mass="86821" checksum="A8C862DFFCC99444" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZGK4</accession>
    <name>C7ZGK4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_42052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyketide transferase af380 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698925">
        <property type="protein sequence ID" value="EEU36818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042531.1">
        <property type="nucleotide sequence ID" value="XM_003042485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZGK4"/>
    <dbReference type="GeneID" id="9669936"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_42052"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_42052"/>
    <dbReference type="eggNOG" id="ENOG502S0U8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048587_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZGK4"/>
    <dbReference type="OMA" id="GSLWHTE"/>
    <dbReference type="OrthoDB" id="2498029at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051411">
        <property type="entry name" value="Polyketide_trans_af380"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751:SF1">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="2">
        <location>
            <begin position="16"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU36818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="303" mass="32921" checksum="70475EAC81383C44" modified="2009-10-13" version="1">MANNVTFQNRGVRIAALLHLPDDFQEDRKYPALVGVHPAGGVKEQTIGLYAQQLATHGFVVLVYDSSYQGASGGEPRLLEDPTTRVEDARCAADFLTTQSFVDTERMGVFGVCAGGGYALAVAQTERRFKAVAGVSATPMGEAARGFFGNPIPPAEQIKSLEAAAAQRTAEANGAAPIYIPFVPERLEDIDDKTPTMLREGYDYYRAPRGQHPNSKGRFLMTSMDKMLAFSTFPLIPTLLTQRLLLIAGSEADTKIYSDEAYALSKGPKELFIVEGATHIALYDKPEYVGQAIEKLASFFGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZGL2</accession>
    <name>C7ZGL2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_42319</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698925">
        <property type="protein sequence ID" value="EEU36821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042534.1">
        <property type="nucleotide sequence ID" value="XM_003042488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZGL2"/>
    <dbReference type="GeneID" id="9670125"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_42319"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_42319"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="C7ZGL2"/>
    <dbReference type="OMA" id="FWYMPKE"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF54">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="52"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU36821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="509" mass="56374" checksum="BE2C16E35D347C83" modified="2009-10-13" version="1">MDRTVPDHEKAPQARTIDNIRVLGLTDEDADFYNNTTPEQRKTIIKKVDRRLVPLLAVLYLISHLDRANIGNAKIEGLVEDLNLVGNQYNIVLSLFFIPYILLEIPSNILLKKFSRPSVYLGSLVTIWGIIMTLHGVVKGFGSLLAVRILLGVFEAGFYPGAVYLCTFWYMPKDLATRIAYFYCTSALSGAFSGLLAAGIAQMDGVGGYEGWRWIFILEGLATIVLGVMCYFLLIDSPALSGKWLTPNEIRFLELQSFIKQGGRFSQESDDKKFDWHDMKMILCNWRLYMQAYILLCISACSYGTKFTLPSIVKAMGFTNTNAQLMTVPAYVAGGISSVCFAKISDHFHWRMPFVAIPLALIAIGYSVVMGFQGDMTGSHTGPGYFALVLTCIGIYPVQPAGSSWAANNLAPSSRRAIGVAFNICVGNIGGIIGSYMYLDKEAPRYQTGFGLSLAFGASGMLVALLLELSYKWGNKTKAKLSEEDIRSRYTEEELLKLGDKSPLFKYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZI20</accession>
    <name>C7ZI20_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_86961</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698929">
        <property type="protein sequence ID" value="EEU36389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042102.1">
        <property type="nucleotide sequence ID" value="XM_003042056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZI20"/>
    <dbReference type="GeneID" id="9674375"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86961"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86961"/>
    <dbReference type="eggNOG" id="ENOG502RP4G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_660514_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZI20"/>
    <dbReference type="OMA" id="SAWERTN"/>
    <dbReference type="OrthoDB" id="9930022at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU36389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="423" mass="47661" checksum="D96112C39DA5D7C6" modified="2009-10-13" version="1">MSLRKTSCAACVSAKCRCDRDLPLCRRCRQKSLPCEYPYPPAGQSDLTNQEEPMPSDTAFSGLGNIGSLDVTEFLDFDLTEIDGPSVADAWESVGSQIAANFEHLPVPESDEALHSLLWPFPDDNATNSDAHRATDHSRRHRKQRRRAFQQARQTSIAPPLQGIWPRGCEVETWNFCAKELLSFVTLFATTATSPFILQPTDNGLHASLQRALGVCAASCTLREPQFGQLFEAEMQHLINTSVVGDMSVVPEDAYSQALSAFRQNLARLQAMVLYQIIGLFSTSHVQRHRAKQNEALMASWTRELLLCIQLLELKSKVKMWMFPRSNLNNPQSVREETSVLSSSHDMPLQKEEIESAYRAILVSYLARSCTSATRNYNKEIHTMSYNDFADLWGQQKSMPGLDIHDRFILLLIVAFTYTHQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZII7</accession>
    <name>C7ZII7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_87158</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698930">
        <property type="protein sequence ID" value="EEU36269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041982.1">
        <property type="nucleotide sequence ID" value="XM_003041936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZII7"/>
    <dbReference type="GeneID" id="9674304"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87158"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87158"/>
    <dbReference type="eggNOG" id="ENOG502STC2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_378588_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZII7"/>
    <dbReference type="OrthoDB" id="5243894at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000177">
        <property type="entry name" value="Apple"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00223">
        <property type="entry name" value="APPLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002989191" description="Apple domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="4">
        <location>
            <begin position="501"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU36269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="732" mass="81358" checksum="5E4F2D988441895B" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJC2</accession>
    <name>C7ZJC2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_77205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698933">
        <property type="protein sequence ID" value="EEU35826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041539.1">
        <property type="nucleotide sequence ID" value="XM_003041493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJC2"/>
    <dbReference type="GeneID" id="9673890"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77205"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77205"/>
    <dbReference type="eggNOG" id="ENOG502SXXA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045009_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZJC2"/>
    <dbReference type="OMA" id="VIRYHNG"/>
    <dbReference type="OrthoDB" id="3643156at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002987152" evidence="2">
        <location>
            <begin position="17"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU35826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="395" mass="43302" checksum="1BC272CC2775731B" modified="2009-10-13" version="1">MKLQNLFALFVLAVDASEIFPPCQKHDCVPSGVYTAPGIGFGLSFSSGTAAAHLHNGTVLDLAFVRAKPDYTALMARLIALPEAPPPLNRWRKWRRSINKKLRRPATPDVGTLAEMLTSLRDAATTALAPINPLDRVVVTTPPMPGLADYDLIDALEYASLRPWVCSDFCEELPYADPGFPFGPGVGYPEELTEAHAVMAGHGLGLCEDYDNLDLCFNEEQSMPLEKVMVVGLTETDFRAEVMKTQGSFPEFPDIIYGFVDLTAGLNARGGFQSEEAYWAYIGSRLKMLVSRLPMKLTRVWLAGENSTHPAFLDTIREAIEGSGHGYVFGQGGVDAGQLLERSGAISPTFSSARGAAQYARWRQQAPLGCYERPGCKDERRGDGHDSREKKIDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJW4</accession>
    <name>C7ZJW4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_87957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698936">
        <property type="protein sequence ID" value="EEU35703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041416.1">
        <property type="nucleotide sequence ID" value="XM_003041370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJW4"/>
    <dbReference type="STRING" id="660122.C7ZJW4"/>
    <dbReference type="GeneID" id="9676284"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87957"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87957"/>
    <dbReference type="eggNOG" id="ENOG502RKU1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1555679_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZJW4"/>
    <dbReference type="OMA" id="FERGLLC"/>
    <dbReference type="OrthoDB" id="5098890at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="172" mass="19774" checksum="6B3C2625E5164F24" modified="2009-10-13" version="1">MGEVSGETHGWTENKFKDVRARGNKWLALCKFSDTRSGLSVSPGLLCFFLMGDNPFGIHRDDYLSIQDETQQRVFVDLLELNNYTTALFAAGNAYVGTFDGSTSVRFRFEQERREIDWQNQDQDEIISLLSVLDEEDQEVMHGEVIGEEEDDEEEDDEEEDEEEEDDRKGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKM1</accession>
    <name>C7ZKM1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_51266</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698940">
        <property type="protein sequence ID" value="EEU35431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041144.1">
        <property type="nucleotide sequence ID" value="XM_003041098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKM1"/>
    <dbReference type="STRING" id="660122.C7ZKM1"/>
    <dbReference type="GeneID" id="9675707"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51266"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51266"/>
    <dbReference type="eggNOG" id="ENOG502SJPJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009030_0_2_1"/>
    <dbReference type="InParanoid" id="C7ZKM1"/>
    <dbReference type="OMA" id="ERMSQWL"/>
    <dbReference type="OrthoDB" id="5089701at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="120"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU35431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="717" mass="80820" checksum="043A350D69D02C47" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKP6</accession>
    <name>C7ZKP6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_51245</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698940">
        <property type="protein sequence ID" value="EEU35481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041194.1">
        <property type="nucleotide sequence ID" value="XM_003041148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKP6"/>
    <dbReference type="GeneID" id="9675724"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51245"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51245"/>
    <dbReference type="eggNOG" id="ENOG502QU6M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021993_3_1_1"/>
    <dbReference type="InParanoid" id="C7ZKP6"/>
    <dbReference type="OMA" id="NPRIQST"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF16">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="48"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU35481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="446" mass="48357" checksum="B322304952187F57" modified="2009-10-13" version="1">MATVTQTETSSVPATFELQSQHESPRNSLHDPEPEHVSDKPSKADLLRIMSVAFSFFVAGVNDGSVGALVPHVIRDYNVTTAIVSSVYGANFMGWFLAAFSNTHLCQILDLGAMLALGAGLQVLAHALRAWRPPFALFTITFMLASLGQAYQDTHGNTFVAGVKGSHRWLAFIHAMYMAGCLVGPFVATGVASAGSVSRWYLFYIFPLGIGVLNMALVAVAFWDTMGIKRKQPVTERTLEADDETPASRSEDAFLLMKEALRTKSVWLISLFFFFFLGATLTASGWIVEYLVAVRDGNINQMGFVPAGFSGGSLLGRLFLAEPTHRFGVRRMIFGFTIISIGLQILFWLVPNIIAASIAISLLGFFMGPYFATLFAPRIRSTALSFVFVFAQLGGCLFPIITGLFAASAGVAVLQPVLCGLLTATAVTWLFVPMPKEGDNPALHQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLI2</accession>
    <name>C7ZLI2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_88684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698945">
        <property type="protein sequence ID" value="EEU35121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040834.1">
        <property type="nucleotide sequence ID" value="XM_003040788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLI2"/>
    <dbReference type="GeneID" id="9679248"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88684"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88684"/>
    <dbReference type="HOGENOM" id="CLU_1482376_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZLI2"/>
    <dbReference type="OrthoDB" id="5068012at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU35121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="182" mass="19889" checksum="B053931D5EB05A76" modified="2009-10-13" version="1">MDAPSPSSPSQAKLISITAVLVITILACLIQCFSGQKTPSTTAQANYQTDSGPEPMHSFLDLNAKASPFHPPSSSATKGSPQHRALRSAIIDSFQEKGQPLIEMAEKRRKRSGYGEPGQNIPHGAQSDEEARAHIMSQIVTFLLEDESRAHYAKVFVPALDRAGWSMNSEKRLNSLKGLCRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZM06</accession>
    <name>C7ZM06_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_67889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698948">
        <property type="protein sequence ID" value="EEU34991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040704.1">
        <property type="nucleotide sequence ID" value="XM_003040658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZM06"/>
    <dbReference type="STRING" id="660122.C7ZM06"/>
    <dbReference type="GeneID" id="9679103"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_67889"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_67889"/>
    <dbReference type="eggNOG" id="ENOG502SMXX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004184_3_1_1"/>
    <dbReference type="InParanoid" id="C7ZM06"/>
    <dbReference type="OMA" id="NHALPSW"/>
    <dbReference type="OrthoDB" id="3557394at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF82">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="48"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="410" mass="47044" checksum="BBE33D5CDB59CD4C" modified="2009-10-13" version="1" fragment="single">MAPPTIYSKPLLPNEIRLMVLLPGKWKDPVSCELCIDLLVKKSRRRQYKALSYAWGLESRSNPPKIQVGNMLLPITVNLDCALRHIRRQDEPVVLWVDAVCINQADAKERTTQVLRMADIYSEATEVIVFLGGGPGRQMKGSKKQKDPGPCTVFTNTPLDDNLTNQALSNWTTPGRRQQVTAFDLFCLLRILSQSRGAPDPFEALRQVPDVYLTAMFESLRQMLTTRWWDRIWVVQEAVIAQKITLRYGDVSAPWEMAAEAALTHFQRARIDDDSPVSRDDIKVLNLLSRVQDIDNFRRAWGESDRPNILSLLRDFSNRKASDERDKVYALLGLCDQHTGIRPDYLSEVRETYMLATIDIILHSHSLSVLTGDLGRKERRDLPSWVPDWSATFDEHDRKRVRLFNHYKAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZM15</accession>
    <name>C7ZM15_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_78551</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698948">
        <property type="protein sequence ID" value="EEU34965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040678.1">
        <property type="nucleotide sequence ID" value="XM_003040632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZM15"/>
    <dbReference type="GeneID" id="9679109"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78551"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78551"/>
    <dbReference type="HOGENOM" id="CLU_687211_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZM15"/>
    <dbReference type="OrthoDB" id="5410402at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="16"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU34965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="461" mass="49954" checksum="2CA6F1BE12EB71CE" modified="2009-10-13" version="1">MNHDKNSPDVQDQLPACERCHASKVRCRRAPGEVRCRRCTRAAYSDCHPRPSRRGGRVGQQQARRGSSGPPSTPKPMEEDTLSLPATAVSSNNITTDTTHDLHQQQTHDMNTDTSNALLDLISVSMAPSGDGLSDLSWEPLVHDVGPDSMRAVTLPTSLAPTLSNPSASSHSMRPGLSETLQDGVTSTSGLSTMHKIRGSGSESRSPELSRLPSASYMQALMDLHAQMLSQQDSLLQFLAAPMRYTHVRPTGEISRRASSSSDTTFAAFPEGPVEAALRLGLALRSLLHPNQTCERDMPTALFLISTVLRLASLLHDLLGRLQGMLAQVTNRNTLCAFVFPSVRLGSLLLKEQNDDRLRPLQMHSISMALGAAEGLIDEVIQLTERALPENIADASGTIEDGEGNTKDEFGLQALTQALVAKQEAVIRPSAPRGSTKSNMTNRKGEAKISTQQAFWMLLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZM32</accession>
    <name>C7ZM32_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_39692</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698949">
        <property type="protein sequence ID" value="EEU34925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040638.1">
        <property type="nucleotide sequence ID" value="XM_003040592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZM32"/>
    <dbReference type="GeneID" id="9679024"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_39692"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_39692"/>
    <dbReference type="eggNOG" id="KOG1201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_5_2_1"/>
    <dbReference type="InParanoid" id="C7ZM32"/>
    <dbReference type="OMA" id="LAGTECH"/>
    <dbReference type="OrthoDB" id="10253736at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU34925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="323" mass="34794" checksum="5A93BBDA5DB836AE" modified="2009-10-13" version="1">MSQASTNFASLVSKAETVIHDYNLEHWVVPGLVVSGLGFVYAVNKYLTQRALNHGTKASFDWKKEIILVTGGSGGIGGATVQQLAKRGTKIVVVDVLPLTYKAPSNVHYYKCDLTNYEQLQIVAGKIREQVGDPTVIVANAGVCRGKPVLAATKRDIELTFGVNTIGLIWTIKTFLPALVARNHGHLLIVASQTGHMATAGATDYSASKAAAITIYEGVHSEIKHVHKATAVRVSCISPSHVQTNMFTGIKSVPGMSSMTTGYLADRITRILYGGNARNVLVPATASASPWVRVLPDWLRVYMQDLSSSAFTELKPHDPLKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMA7</accession>
    <name>C7ZMA7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xaa-Pro dipeptidyl-peptidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_55059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698950">
        <property type="protein sequence ID" value="EEU34858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040571.1">
        <property type="nucleotide sequence ID" value="XM_003040525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMA7"/>
    <dbReference type="GeneID" id="9678994"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55059"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55059"/>
    <dbReference type="eggNOG" id="ENOG502QZDY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015590_2_1_1"/>
    <dbReference type="InParanoid" id="C7ZMA7"/>
    <dbReference type="OMA" id="HYENDAH"/>
    <dbReference type="OrthoDB" id="416441at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00976">
        <property type="entry name" value="CocE_NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF10">
        <property type="entry name" value="COCE_NOND FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase C-terminal" evidence="2">
        <location>
            <begin position="319"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU34858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="596" mass="67257" checksum="0C1D2B288516DD90" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMD8</accession>
    <name>C7ZMD8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_88424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698951">
        <property type="protein sequence ID" value="EEU34837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040550.1">
        <property type="nucleotide sequence ID" value="XM_003040504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMD8"/>
    <dbReference type="GeneID" id="9678962"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88424"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88424"/>
    <dbReference type="eggNOG" id="ENOG502SQRC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046320_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZMD8"/>
    <dbReference type="OMA" id="VHNDRIT"/>
    <dbReference type="OrthoDB" id="5426911at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="439" mass="49374" checksum="AC472BEC3C1E64EE" modified="2009-10-13" version="1">MSISTGCCMELAAPGHTVQPSFGHGEPRISPPPKDWDTDPKTTKELWMTVATIAMSSRGPASRTAGSRSGRATTKTGSDAGKRSTSASTRSLFDLSESQVTPESTITNATRSISPRNAKFAKLVLEPRGILINDTNSIVPNAFSHFGTEQPEGDEAIDYKMVPGLSGVNIWITLDDDAIKDITNEYKEMRGQNLCEEEFATLAKELFLHGERRSRSVSQDRQWRAERMLQLVCPPKESAHWRIPPLLDETLAQETDWTWDIRPDCSYWLSLKGFNAKYRFHIQNATYVRDSITCPYFTVEFKRDGESEDVAVRQACAAGAIALFNRYSLHIQARKVNPELADDVSNIRHYTLTLVGHKFVFWVLRPMRDECKKWTGCEMTRLFGADCTDEYAVQELGNWVNEIHRWGLSRHGPSCERDIKNVLNSSGVRTSDANEASTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMF4</accession>
    <name>C7ZMF4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_79754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698952">
        <property type="protein sequence ID" value="EEU34799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040512.1">
        <property type="nucleotide sequence ID" value="XM_003040466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMF4"/>
    <dbReference type="GeneID" id="9678936"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79754"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79754"/>
    <dbReference type="HOGENOM" id="CLU_1777970_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZMF4"/>
    <dbReference type="OrthoDB" id="10525886at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="146" mass="16721" checksum="270F2BA881DE2729" modified="2009-10-13" version="1">MTATSTQRVPISPGGTELDEWYNDTSAQVTPMSWREKRQFQRELRLAGLFGPRRGPGRGPLSFNNLTDEVRDALVQFHNALVRHTETDEDRLEYLDKQQDGLKDLANKLSKKEDLGAKEFFLADLVACTNWFKELLNLVEDLRPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNG6</accession>
    <name>C7ZNG6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_44514</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698967">
        <property type="protein sequence ID" value="EEU34468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040181.1">
        <property type="nucleotide sequence ID" value="XM_003040135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNG6"/>
    <dbReference type="GeneID" id="9677984"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_44514"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_44514"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="C7ZNG6"/>
    <dbReference type="OMA" id="ATIMFIW"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000364">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF79">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="58"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU34468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="511" mass="56693" checksum="B6976839A11B1698" modified="2009-10-13" version="1">MSRRSDISGEKDLEAIGSKADVVHEEVSNRGGLTDEELAFVQDFPEDKRKKLLTKWRLMPILVILYLVAYIDKANIGNAKIEGMLPDLGMTGDQYNIALSIYFIPYILGEVPSNMILDKFRKPSQYMAGIMLIWGGIVISTGFIQNFGQLLAVRTLLGLFESGFFPGAILIISKWFLPNETQTRVAILYTSAATGGAFSGLFAYAIAKLDGVGGIEGWRWIFIIEGIFTVLGAFATWFLLVDSPELSSWLTDEEKRYLILRQATRRVTNSGEYREKTDKGALWAVVKDWKVYLLTVCSWSNAAPNYGLKFSMPSITKGMGFTSSNAQLMTIPPYFCGAISSYLLARCADKFKWRMPFLIGPQTCVLIAFSILMAKAEFIKENLGACYFAVCLACAGMYPILPGVSAWNIDNNPLPTRRAISIAYLNCAGTIGGIYGSYIYKDNEKPKYTTGYGASLGFAIGGILSAVILETALMSLNKKRAKLTEAEIRERYTNEELESMGDRSPLFKYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNM4</accession>
    <name>C7ZNM4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxyvinyl-carboxyphosphonate phosphorylmutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_96581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039727.1">
        <property type="nucleotide sequence ID" value="XM_003039681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNM4"/>
    <dbReference type="STRING" id="660122.C7ZNM4"/>
    <dbReference type="GeneID" id="9677638"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_96581"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_96581"/>
    <dbReference type="eggNOG" id="KOG1260">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027389_3_1_1"/>
    <dbReference type="InParanoid" id="C7ZNM4"/>
    <dbReference type="OMA" id="NGPICAN"/>
    <dbReference type="OrthoDB" id="1923844at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905:SF13">
        <property type="entry name" value="CARBOXYVINYL-CARBOXYPHOSPHONATE PHOSPHORYLMUTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13714">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU34014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="36442" checksum="80A7FAFC04DC5098" modified="2009-10-13" version="1">MTSSIPGELRGVTLHLPNVRGMIPSIQASRMRTMILESYRDPAKIAAHVCTYDGLTSRLAEEAGFPFVFLAGYAVASSYGLPDTGYIALQEVCDKIQEAVRQVSVPVMADGDTGYGSPMNVKRTVESFARAGAAGIMIEDQTWPKRCGHTKGKSVVSRGEAFARMKAAVDARDEGLDIVIQARTDSYNTHGWEEAIYRANKFLEIGVDLVFIEALPDRDTMIRAVKEVKGPLCANIIEGGLTENMSAKDLASIGMVTVAYPWTLVAAHLRSTREALESLKKSFSIGKPEQILSYEEVCYGVGFNKYWALEERYKYDTNGLTNGGEKSGQNGTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNS7</accession>
    <name>C7ZNS7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_106409</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039769.1">
        <property type="nucleotide sequence ID" value="XM_003039723.1"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZNS7"/>
    <dbReference type="GeneID" id="9677894"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_106409"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_106409"/>
    <dbReference type="eggNOG" id="ENOG502SIJX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_250841_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZNS7"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01833">
        <property type="entry name" value="XynB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF5">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002987270" description="SGNH hydrolase-type esterase domain-containing protein" evidence="3">
        <location>
            <begin position="34"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="4">
        <location>
            <begin position="57"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="849"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1078"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1265"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1454"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="849"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1080"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1268"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1471"/>
            <end position="1484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU34056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1484" mass="157753" checksum="821B374D2C7F8986" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZP85</accession>
    <name>C7ZP85_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alcohol dehydrogenase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_85631</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
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        <property type="protein sequence ID" value="EEU34303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003039970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZP85"/>
    <dbReference type="GeneID" id="9677544"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85631"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85631"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_16_2_1"/>
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    <dbReference type="OMA" id="IDWKGPA"/>
    <dbReference type="OrthoDB" id="201656at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
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        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052585">
        <property type="entry name" value="Lipid_raft_assoc_Zn_ADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482">
        <property type="entry name" value="PROTEIN AST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482:SF2">
        <property type="entry name" value="ZINC-BINDING DEHYDROGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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            <begin position="107"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU34303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="470" mass="50716" checksum="5FE4AAD0B94EC79A" modified="2009-10-13" version="1">MSTSTFVTLTPEPVLEAKFPQLQIQETTQKEEQQPASQTAQPSPAAQPQPTQPADQSTSTDSSVPSQIPETTDEHTIPPAQTVLLLHGVRQQYEVTHGYAIPDTKHDHELLVRTNTIGLNPIDWKSPDYGFGIPELPYISGREASGTVVRAPLGPSRVKVNDKVIVISTDYRDLRKATYQQYVVASDFNVVRIPKEITVNQGATLGVAFVAASLSLGVCLGVDFTSVHDGPNVLNLVREVPEESLPQDIRGECLNGILPGEGAKPGDWIAIWGGSSTSAVIAAQLARLVGLRVALVVDNAKHGVRISENPVLRPDLLVDSHDPERAVAILRANTKGKLRFGIDTRGKDTAEILLRALGPEEHRKTPPVNSPPSTPPSEPTVPAHIVGMSGLPKQATAGVIFHTMPVKLYHEVPEVGEALSSWLERLLATRALVPPRIIDVEDGLHNVNKGLDRMRKGEISGGKLLVDIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQ28</accession>
    <name>C7ZQ28_FUSV7</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_89065</name>
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    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698980">
        <property type="protein sequence ID" value="EEU33882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039595.1">
        <property type="nucleotide sequence ID" value="XM_003039549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQ28"/>
    <dbReference type="STRING" id="660122.C7ZQ28"/>
    <dbReference type="GeneID" id="9667114"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89065"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89065"/>
    <dbReference type="eggNOG" id="ENOG502SP9C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_378591_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZQ28"/>
    <dbReference type="OrthoDB" id="5342507at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="608"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU33882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="732" mass="80839" checksum="0E37DECE686E1121" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQ29</accession>
    <name>C7ZQ29_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_89066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698981">
        <property type="protein sequence ID" value="EEU33874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039587.1">
        <property type="nucleotide sequence ID" value="XM_003039541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQ29"/>
    <dbReference type="GeneID" id="9667109"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89066"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89066"/>
    <dbReference type="HOGENOM" id="CLU_1704710_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZQ29"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU33874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="154" mass="17406" checksum="014CB4163621FE2C" modified="2009-10-13" version="1">MSSYESIEDMLNLIVNQATTASRTRQSSTGCYTARVMPDMEVWVLPRGGCPVLFIAPTTSYGYSNRYLCYSTHQETHLRARDDRENGLLIIATMDVVWRDTNKAPHVCQHCIFMIDCPTQDGWATYIKKTLGLGIRDLREIGEVYLSKAIGGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7YH68</accession>
    <name>C7YH68_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_74866</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053579.1">
        <property type="nucleotide sequence ID" value="XM_003053533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YH68"/>
    <dbReference type="STRING" id="660122.C7YH68"/>
    <dbReference type="GeneID" id="9664449"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74866"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74866"/>
    <dbReference type="eggNOG" id="KOG0114">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_25_2_1"/>
    <dbReference type="InParanoid" id="C7YH68"/>
    <dbReference type="OMA" id="HQPDKMV"/>
    <dbReference type="OrthoDB" id="275748at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12241">
        <property type="entry name" value="RRM_SF3B14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000286">
        <property type="entry name" value="Putative pre-mRNA branch site protein p14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034150">
        <property type="entry name" value="SF3B6_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF58">
        <property type="entry name" value="RNA-BINDING PROTEIN 19-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="14"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU47866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="116" mass="13195" checksum="80CD9FF3314BA0F8" modified="2009-10-13" version="1">MSSRGGKLAPEVNRALFVKNLSYNVTPEELFDLFGKFGPIRQVRQGIASNTKGTAFVVYEDVMDAKQACDKLNGFNFQNRYLVVLYHQPDKMARSKEDLEARRESLAQLKKQHGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHB6</accession>
    <name>C7YHB6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_74914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054316.1">
        <property type="nucleotide sequence ID" value="XM_003054270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YHB6"/>
    <dbReference type="GeneID" id="9664472"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74914"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74914"/>
    <dbReference type="eggNOG" id="ENOG502S8YJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2038670_0_0_1"/>
    <dbReference type="InParanoid" id="C7YHB6"/>
    <dbReference type="OMA" id="DIGIHKE"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846:SF1">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU48603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="121" mass="13580" checksum="2647D490254CC18B" modified="2009-10-13" version="1">MPRSKKKGNADGIAKQLAGLTLNSTAPPDSDSGSEPKHKRLCADLGISGDLGSKTKCRKEIKSVNVNIKQFLQSKNKPEDVRFFKNRHALIQYTRRTSWFFPRRKIPKGDPLAALLKEMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHI9</accession>
    <name>C7YHI9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_30594</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <end position="147"/>
        </location>
    </feature>
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        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
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        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEU47919.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="695" mass="77302" checksum="ABACCB4F712D22CD" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHM0</accession>
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        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
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            <taxon>Hypocreales</taxon>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
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                <person name="Selker E.U."/>
                <person name="Salamov A."/>
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                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
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            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
        </subcellularLocation>
    </comment>
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    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_57472"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12949">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MSC"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="HeH/LEM" evidence="10">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Man1/Src1-like C-terminal" evidence="9">
        <location>
            <begin position="303"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="62"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="641"/>
            <end position="679"/>
        </location>
    </feature>
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        <location>
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            <end position="106"/>
        </location>
    </feature>
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        <location>
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            <end position="150"/>
        </location>
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        </location>
    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF09402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12949"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEU47935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="679" mass="75915" checksum="471DD5556751EA97" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7YII4</accession>
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        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">NECHADRAFT_75333</name>
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    <organism evidence="4 5">
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        <lineage>
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            <taxon>Sordariomycetes</taxon>
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            <taxon>Hypocreales</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EEU48101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053814.1">
        <property type="nucleotide sequence ID" value="XM_003053768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YII4"/>
    <dbReference type="STRING" id="660122.C7YII4"/>
    <dbReference type="GeneID" id="9664646"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75333"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75333"/>
    <dbReference type="eggNOG" id="ENOG502SFXK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017870_1_0_1"/>
    <dbReference type="InParanoid" id="C7YII4"/>
    <dbReference type="OMA" id="WTAWPLK"/>
    <dbReference type="OrthoDB" id="5412288at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019622">
        <property type="entry name" value="Rrn9_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10680">
        <property type="entry name" value="RRN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="505"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="457"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="553"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="457"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="560"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU48101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="589" mass="66075" checksum="9BA8E007EAB45F79" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIJ8</accession>
    <name>C7YIJ8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cutinase palindrome-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_73420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_73420"/>
    <dbReference type="eggNOG" id="KOG1601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024414_0_0_1"/>
    <dbReference type="InParanoid" id="C7YIJ8"/>
    <dbReference type="OMA" id="HTDTIEM"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PAS domain"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658:SF18">
        <property type="entry name" value="PROTEIN GAT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="103"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="7">
        <location>
            <begin position="396"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="256"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
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        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="434"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU48820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="49879" checksum="6B19E1452F518285" modified="2009-10-13" version="1">MTGGQMGADGQDSTDIMALLDNNMLGSMGDVSMGLDAVDESSMTGSFGGSNAQTSTEESVARAENQFNTAANNVPGAGPLPAGPFAQMNLTSAASTLTEFTKRRNWPAKVVEELRDFLQILDANGRIKYASPSILNVTGYSVEEIQDIFLKDLIHPDDRGVFVAELNESIASGNPLRLFYRFKKKDGKFAIFETVGHAHIAGSKFAPNPNNQSPFCQAVFMMARPYPTKNAGLLDSFLEHKIENERLKRRIAELRREEEAENDEAQKQWMQSQEGRSDVTPSEGTGVSSNFFRPSTDRGLTDADRAALNKSLTRENLEGAAGSRPDSLNDKMARYEGASHTETIEMLTGLRYIEGERSRGITTGNASPTLIKGDAGIAIPLERDPRTGDKKKKLKTSEEYVCTDCGTLDSPEWRKGPSGPKTLCNACGLRWAKKEKKRNSSVNHHHAPGPAIDHSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIN6</accession>
    <name>C7YIN6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_75387</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054550.1">
        <property type="nucleotide sequence ID" value="XM_003054504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIN6"/>
    <dbReference type="STRING" id="660122.C7YIN6"/>
    <dbReference type="GeneID" id="9664672"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75387"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75387"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="InParanoid" id="C7YIN6"/>
    <dbReference type="OMA" id="KDMMQAF"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="CYP57A1-like"/>
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    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF168">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU48837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="51548" checksum="63D13340EB21E539" modified="2009-10-13" version="1">MGLLADLSLTRLCLVAVSVVIAGLGTRPLVRIGPNELLSTDPDVLRNMSAVRSTYTKGDFYMSGRIVPEVDNVVSERNEVKHKAMKAKMTPGYSGKENEGFGFEAGLDRQLLNFIALIDRKYASAPDETRPVDLAEKTQFFALDAIGDVSFGEPFGYLTQDEDLYHYNEINASSLSAMDVVSVYPWLTKIVHRWPLKLLLPREGDQVGFGRLMGFATQFVRGRLAEGATPDKDMMQAHINNGMNEEELIQQVFISIIAGSNSSAHALRMIILSIITNPPAHASLLAEIRQHVSSVNTPISWAQIQTLPYLQAVVREGLRMWPPLAGLGFKQVPPEGDTINGFFVPGGTQVGQGFHAVGRSRLVWGDDADMFRPERWLLADESELKRMIAAWDTHFGHGKYVCLGKPIALMEIHKAVFELIKRYDFAIMNPEKPISIQASVFLFASDFWVRITRRNDPDIEGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIZ6</accession>
    <name>C7YIZ6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_75500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053893.1">
        <property type="nucleotide sequence ID" value="XM_003053847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIZ6"/>
    <dbReference type="ESTHER" id="nech7-c7yiz6">
        <property type="family name" value="Bacterial_esterase"/>
    </dbReference>
    <dbReference type="GeneID" id="9663675"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75500"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75500"/>
    <dbReference type="eggNOG" id="ENOG502REH0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_277996_0_0_1"/>
    <dbReference type="InParanoid" id="C7YIZ6"/>
    <dbReference type="OrthoDB" id="9978720at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12809">
        <property type="entry name" value="Esterase_713_like-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF4">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="897"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1032"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="653"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="905"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="959"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1060"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1101"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1111"/>
            <end position="1120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU48180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1139" mass="123604" checksum="38D95BEC4DA5145E" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJ73</accession>
    <name>C7YJ73_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribulokinase/uridine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_75579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053932.1">
        <property type="nucleotide sequence ID" value="XM_003053886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJ73"/>
    <dbReference type="FunCoup" id="C7YJ73">
        <property type="interactions" value="341"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YJ73"/>
    <dbReference type="GeneID" id="9676566"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75579"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75579"/>
    <dbReference type="eggNOG" id="KOG2878">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056986_0_0_1"/>
    <dbReference type="InParanoid" id="C7YJ73"/>
    <dbReference type="OMA" id="FAGPQHF"/>
    <dbReference type="OrthoDB" id="347435at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU48219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="34443" checksum="300E629A56D05E87" modified="2009-10-13" version="1">MIDAKAIESVLAIFLPLINTHRQKTSKPFVLGLSGLQGSGKSTWAGALSQALTTQHNLKTRIVSLDDLYLDHAELVAIREANPDNGLLQSRGQPGTHDEVLAKEFFSKLGDFNTDNGGYVAWPAYDKSLHSGQGGRVPVGQWEKVPLDQGLDVLIFEGWCLGFKPLTKEETTQKWKQAKESPDSSLTNTLADHDISHLLLINENLSRYCNSFTGPQHFDAFLHLSTDKLVHVYEWRLDQEKALRKHKTGMTDEQVTRFVRGYMPAYELFLERLQKENFFEDGEKKHVQVVLNRDREVVEVKEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJJ4</accession>
    <name>C7YJJ4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_90543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053998.1">
        <property type="nucleotide sequence ID" value="XM_003053952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJJ4"/>
    <dbReference type="GeneID" id="9676621"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90543"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90543"/>
    <dbReference type="eggNOG" id="ENOG502QSKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_0_2_1"/>
    <dbReference type="InParanoid" id="C7YJJ4"/>
    <dbReference type="OMA" id="IRPYYLM"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU48285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="41464" checksum="340408220F05801C" modified="2009-10-13" version="1">MSSPKSDQDVPKSSPKSSPKSPTSPAEVVQSSSPGDTTTRMMLERIPHMRTMEGDIVSSTASLSESIFDYRNLHGRTFQNSKTTEYWGPNDDRQNNGLDIAHQFMVMLKNDRLFDAPVTRMSKVLDVGTGTGIWAIDMADAYPETEIIGTDISAIQPSWVPPNCVFHIEDAQLEWTFRPESFDFIHIRALYGSISDWGELYRQAYTALSPGGWIENMEINIHMHSDLPEIRDDPDHIFKRWAKVFWEATDKMNRTLRIAMDGTQRKLITEAGFEKVVEKTYQVPCGAWSSDPKMKQIGAYNLAFMDESLEGFALFILREIMGWEYDEVQIFVMEMRRAIRNTKIRPYYLITNVYGQKPETAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJL5</accession>
    <name>C7YJL5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_75721</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054008.1">
        <property type="nucleotide sequence ID" value="XM_003053962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJL5"/>
    <dbReference type="GeneID" id="9676632"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75721"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75721"/>
    <dbReference type="eggNOG" id="ENOG502SMHV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_3_0_1"/>
    <dbReference type="InParanoid" id="C7YJL5"/>
    <dbReference type="OMA" id="LPWRILM"/>
    <dbReference type="OrthoDB" id="5417887at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF42">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="30"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="279"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="327"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU48295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="395" mass="43960" checksum="DCA7FD6D635CCE76" modified="2009-10-13" version="1">MAGIDAEERGTRLLAACWALAAASALLLFLRIYCKLWRGRGLWWDDHFLIMSWASLAIAVSINTYLVSLGFGRHIWTISDENKKTINLFTILVATFGIIATTTSKTSFAVTLYRIATNQWMKYFLIFIIVTINISMNLVWIFGFAKCTPVERVWDKTVEGTCWNPQKLLKYQLFAAYYSAILDFVLAFLPWPILMGMSMRRRERLGVAVAMSLGAIAGICGIVKAVLVVSMSSTDITYDRVDLTIWTLTEPAASIMAVCIPVLRMLYRELKSSQKSYLRNRSHTNPLDGTNATNVASSNTKSKRYGPHSKYGRNSVVIMSAAGWQESQEALQDPTSTQTSRSRSSPSTNGGVLKTEEVRVHHERLSTFSDENSIELKNMGNTASGTGPKGNAPSF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-12-14" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7YK87</accession>
    <name>TRM5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine(37)-N(1))-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA methyltransferase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">TRM5</name>
        <name type="ORF">NECHADRAFT_98685</name>
    </gene>
    <organism>
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Predominantly in the mitochondria and in the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="1"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054117.1">
        <property type="nucleotide sequence ID" value="XM_003054071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YK87"/>
    <dbReference type="FunCoup" id="C7YK87">
        <property type="interactions" value="1094"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="NechaT98685">
        <property type="protein sequence ID" value="NechaP98685"/>
        <property type="gene ID" value="NechaG98685"/>
    </dbReference>
    <dbReference type="GeneID" id="9664123"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_98685"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98685"/>
    <dbReference type="eggNOG" id="KOG2078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022610_2_2_1"/>
    <dbReference type="InParanoid" id="C7YK87"/>
    <dbReference type="OMA" id="VGSHSQF"/>
    <dbReference type="OrthoDB" id="408788at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070901">
        <property type="term" value="P:mitochondrial tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.110:FF:000001">
        <property type="entry name" value="tRNA (guanine(37)-N1)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03152">
        <property type="entry name" value="TRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025792">
        <property type="entry name" value="tRNA_Gua_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF36">
        <property type="entry name" value="TRNA (GUANINE(37)-N1)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000414166" description="tRNA (guanine(37)-N(1))-methyltransferase">
        <location>
            <begin position="21"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="304"/>
            <end position="305"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="465" mass="52510" checksum="4F6A8CDFDF2BF133" modified="2009-10-13" version="1" precursor="true">MDKNSQLRDMNLFRAPAARAAKTLDRSVFAKTLNAAAASISENRLLSKYRKELEKTQEVLFMERFNPILPDPDPSLASQGRKCIVLSPQIKPASPETWSPTLQEASKLGELKVVPYDLEITYDFWNYFDVVKSILPEELHGEIPSGFNTVGHVAHLNIRDQYLPYKNIIAQVLLDKNPHIKTVINKIDNVGSENEFRTFAYEVLGGPDNMNVEVSEAGCIFRFDYSKVYWNSKLDTEHKRITSFFKPGEVVADVMAGIGPFAVPAGKKGVFVWANDKNPESHRYLEDAIQKNKVWEFVKPFNHDGHDFIRTSADLVLEASKRGDCAVIKPPRPPRKSAAPPPEPVRVPVPPTISHFVMNLPASAIEFLHNYRGLYHGHEDLFEPHTETKLPIVHVHCFSAKMDDDTPLKDICERIHKEIGVMLKPGDAEKEGEVLIYDVRDVAPAKRMFCASFRLPREVAFAARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C7YKT5</accession>
    <name>C7YKT5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_36119</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052847.1">
        <property type="nucleotide sequence ID" value="XM_003052801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YKT5"/>
    <dbReference type="GeneID" id="9670917"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_36119"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_36119"/>
    <dbReference type="eggNOG" id="ENOG502SRVW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_0_3_1"/>
    <dbReference type="InParanoid" id="C7YKT5"/>
    <dbReference type="OMA" id="CVKWSIL"/>
    <dbReference type="OrthoDB" id="5421689at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="25"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU47134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="373" mass="42260" checksum="602C263E28880D81" modified="2009-10-13" version="1">MPGLQNNAYAAVSITWGAALIAVILRIYARRLTKQTWWFDDYFCVSAFVFGSAYNSVIIVWAIDWYLGQELDPTLSNQQRERILLYNRLLMLCTEYCYAFSIASSKFTILSLYWRLFKHSSIRVPIQIMLTASLAWILLRIFMVSLQCIPLKFFWDKSINGRCGIDESQFFFGTVLTHFVMDIIILILPIIEVRKLHMRLGKKLAVIGLFLIGSVVCVASIIVLIESITYDEKTTQMPRDVALNFIWGDVEVNVAIVSSCFPLLRPVFSLILPKSFLSSFSSRHHTSRATRSHHMKLATIHIRTNKEKGNDESSSTHQLADLEQGHGAEPIQTVISSHPRSSRSSSSGEGDMEGIHVRNDTVVKIVPACHLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7YL14</accession>
    <name>C7YL14_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_35125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052887.1">
        <property type="nucleotide sequence ID" value="XM_003052841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YL14"/>
    <dbReference type="STRING" id="660122.C7YL14"/>
    <dbReference type="GeneID" id="9670959"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_35125"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_35125"/>
    <dbReference type="eggNOG" id="KOG3957">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021588_1_1_1"/>
    <dbReference type="InParanoid" id="C7YL14"/>
    <dbReference type="OMA" id="RWIQLHC"/>
    <dbReference type="OrthoDB" id="2308815at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052985">
        <property type="entry name" value="CoA-trans_III_biosynth/detox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229:SF1">
        <property type="entry name" value="ALPHA METHYLACYL-COA RACEMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229">
        <property type="entry name" value="CAIB/BAIF FAMILY ENZYME (AFU_ORTHOLOGUE AFUA_1G05360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU47174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="543" mass="60362" checksum="D3CA6726222AF0B1" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNR4</accession>
    <name>C7YNR4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_100222</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052334.1">
        <property type="nucleotide sequence ID" value="XM_003052288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNR4"/>
    <dbReference type="FunCoup" id="C7YNR4">
        <property type="interactions" value="399"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YNR4"/>
    <dbReference type="GeneID" id="9672954"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100222"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100222"/>
    <dbReference type="eggNOG" id="KOG0113">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045151_0_1_1"/>
    <dbReference type="InParanoid" id="C7YNR4"/>
    <dbReference type="OMA" id="TDEYKPT"/>
    <dbReference type="OrthoDB" id="4207594at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051183">
        <property type="entry name" value="U1_U11-U12_snRNP_70-35kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022023">
        <property type="entry name" value="U1snRNP70_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952:SF5">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12220">
        <property type="entry name" value="U1snRNP70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="102"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="271"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="353"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="382"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU46621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="431" mass="47925" checksum="D4D953BD75D76DFC" modified="2009-10-13" version="1">MTDKLPPNLLALFAARPPLRWVEPPDHAPQNRKTAPISGVAQFLPELQKYKETDVYNPTESWLQARDRKKQEKKQDLEELVTQAPKLYKPNEDPNVRGDAFKTLIVARLSYDADERDLEKEFGRFGPIERIRIIVDTHAHEKPNKKKKPHRGYAFVVFEREKDMRERGPQACPFFKVYGETQGPSSLPVSAIPFLLSTHSARKVLFMDRRIKVDVERGRTVKGWRPRRLGGGLGGRGYTRSMPSRPMGPGGFGGGFRGGYKGFDGGRGRGGFRGGFGGRGGFRSGGGDYSRGDRNGYGAPSDAPSGPGFDRRNGGYSDRGDRGDRGGDRRGDRGPGGYESRGGGRSYDDRHGGGGGGYRDGGGSGRFGDRDNRRTGSNMEPIGRREGGREGGREGGYRERDRDYDRPRDDDGGRKRGYDGGYEDPRKLRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7YP06</accession>
    <name>C7YP06_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_79489</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051919.1">
        <property type="nucleotide sequence ID" value="XM_003051873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YP06"/>
    <dbReference type="GeneID" id="9670904"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79489"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79489"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_11_0_1"/>
    <dbReference type="InParanoid" id="C7YP06"/>
    <dbReference type="OMA" id="WRIAAIC"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="63"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU46206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="546" mass="60515" checksum="CC291C4BA3079A92" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7YP66</accession>
    <name>C7YP66_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_78651</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051958.1">
        <property type="nucleotide sequence ID" value="XM_003051912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YP66"/>
    <dbReference type="GeneID" id="9673111"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78651"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78651"/>
    <dbReference type="eggNOG" id="ENOG502QQEE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_375996_0_0_1"/>
    <dbReference type="InParanoid" id="C7YP66"/>
    <dbReference type="OMA" id="TTHRNKF"/>
    <dbReference type="OrthoDB" id="5240840at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU46245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="691" mass="72692" checksum="149FB99B4A7FC7DF" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7YP97</accession>
    <name>C7YP97_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH-ubiquinone oxidoreductase 21.3 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_59807</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003051473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YP97"/>
    <dbReference type="STRING" id="660122.C7YP97"/>
    <dbReference type="GeneID" id="9673127"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_59807"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_59807"/>
    <dbReference type="eggNOG" id="ENOG502S81D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088319_0_0_1"/>
    <dbReference type="InParanoid" id="C7YP97"/>
    <dbReference type="OMA" id="TMMNLRE"/>
    <dbReference type="OrthoDB" id="1913277at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039205">
        <property type="entry name" value="NDUFA11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21382:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21382">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU45806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="22746" checksum="CAA8EA51027622BE" modified="2009-10-13" version="1">MEPPRRSTPRAHFEPDTVFKPYDVLDDTAKAGLVGGASGLFIASIRNALAKTNVGAFSVFTRGAPIIGLATAAPAAYVFFSRTAMNLREENDPWSAGFGGFMMGAVLGLPSRRMPVVMGLGASIGVFQGMFYYLGNRYDTFYKEDDTFERKETIRRTTRLPLEQTISEIGEGRGIRPPGYDERRAERLKEKYGFEVNPVNATVAGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPS4</accession>
    <name>C7YPS4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_92581</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052056.1">
        <property type="nucleotide sequence ID" value="XM_003052010.1"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YPS4"/>
    <dbReference type="GeneID" id="9668767"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_92581"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_92581"/>
    <dbReference type="eggNOG" id="KOG1998">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000595_0_1_1"/>
    <dbReference type="InParanoid" id="C7YPS4"/>
    <dbReference type="OMA" id="LWDNQAF"/>
    <dbReference type="OrthoDB" id="18896at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
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        <property type="entry name" value="DOCK_C_lobe_A"/>
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    </dbReference>
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        <property type="entry name" value="MYOBLAST CITY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23554">
        <property type="entry name" value="TPR_DOCK"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
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    <keyword evidence="2 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="7"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="C2 DOCK-type" evidence="9">
        <location>
            <begin position="610"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="10">
        <location>
            <begin position="1440"/>
            <end position="1844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="90"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="408"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1770"/>
            <end position="1799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1849"/>
            <end position="1880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1905"/>
            <end position="2031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1775"/>
            <end position="1793"/>
        </location>
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        <location>
            <begin position="1861"/>
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        </location>
    </feature>
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        <location>
            <begin position="1916"/>
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        </location>
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        <location>
            <begin position="1929"/>
            <end position="1940"/>
        </location>
    </feature>
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        <location>
            <begin position="1989"/>
            <end position="2000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="2003"/>
            <end position="2019"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEU46343.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2031" mass="226005" checksum="B1674529D22B6082" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPT9</accession>
    <name>C7YPT9_FUSV7</name>
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        <recommendedName>
            <fullName evidence="4">DNA polymerase delta subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_78869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077732_0_0_1"/>
    <dbReference type="InParanoid" id="C7YPT9"/>
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    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="DNA_pol_delta_4"/>
    </dbReference>
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        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA_pol_delta_4"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU46350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22086" checksum="6F3B8D48765BFA8B" modified="2009-10-13" version="1">MPATRRSAGGARSRGPPAKGQSTLTSFSSRVTKNVAKSAKKSIISPSITKIDPTQAPKQTKVEEAVVEEPEPIEVDEEEEQPEVVPEPEKSEAELRAEQITDAQIKKYWKTIEEQWTSPRLHQQGVSLSERVLRYFDVSSQYGPCIGTPRMKRWKRAERLGLNPPIEVLAVLLKEETKGNKVQRAHMDEILNSTAVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQ21</accession>
    <name>C7YQ21_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">NECHADRAFT_68291</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051662.1">
        <property type="nucleotide sequence ID" value="XM_003051616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQ21"/>
    <dbReference type="STRING" id="660122.C7YQ21"/>
    <dbReference type="GeneID" id="9673408"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_68291"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_68291"/>
    <dbReference type="eggNOG" id="KOG2518">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008978_2_1_1"/>
    <dbReference type="InParanoid" id="C7YQ21"/>
    <dbReference type="OMA" id="CGSEDQI"/>
    <dbReference type="OrthoDB" id="26491at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:DNA repair"/>
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        <property type="entry name" value="H3TH_EXO1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Exonuclease 1, putative"/>
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        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="EXO1_H3TH"/>
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        <property type="entry name" value="PIN-like_EXO1"/>
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        <property type="entry name" value="XPG-I_dom"/>
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        <property type="entry name" value="XPG/Rad2"/>
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        <property type="entry name" value="XPG_DNA_repair_N"/>
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    <dbReference type="PANTHER" id="PTHR11081:SF65">
        <property type="entry name" value="DNA DAMAGE-INDUCIBLE PROTEIN DIN7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="16">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="15">
        <location>
            <begin position="138"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="407"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="531"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="703"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="534"/>
            <end position="555"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="556"/>
            <end position="572"/>
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    </feature>
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        <location>
            <begin position="602"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="624"/>
            <end position="649"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="716"/>
            <end position="728"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00010563"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEU45949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="743" mass="82730" checksum="0CFE52357962F7C4" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQ85</accession>
    <name>C7YQ85_FUSV7</name>
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        <recommendedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_92688</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EEU46427.1"/>
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        <property type="nucleotide sequence ID" value="XM_003052094.1"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 4"/>
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        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF125">
        <property type="entry name" value="GTPASE ACTIVATOR (BEM2), PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04450)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF48350">
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        <property type="match status" value="1"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <begin position="451"/>
            <end position="642"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="351"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="644"/>
            <end position="705"/>
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    </feature>
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        <location>
            <begin position="720"/>
            <end position="756"/>
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            <begin position="1"/>
            <end position="24"/>
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            <end position="70"/>
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        <location>
            <begin position="79"/>
            <end position="120"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="206"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="214"/>
            <end position="223"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="266"/>
            <end position="280"/>
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    </feature>
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        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="654"/>
            <end position="665"/>
        </location>
    </feature>
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        <location>
            <begin position="666"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="723"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU46427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="756" mass="83683" checksum="12B617B5F0084C26" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQH0</accession>
    <name>C7YQH0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_68428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003052137.1"/>
    </dbReference>
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        <property type="interactions" value="734"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YQH0"/>
    <dbReference type="GeneID" id="9673561"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_68428"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_68428"/>
    <dbReference type="eggNOG" id="KOG1302">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016678_3_1_1"/>
    <dbReference type="InParanoid" id="C7YQH0"/>
    <dbReference type="OMA" id="EFHIFFV"/>
    <dbReference type="OrthoDB" id="10262287at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sec-1-like_dom1"/>
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        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
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        <property type="entry name" value="Sec1-like"/>
    </dbReference>
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        <property type="entry name" value="Sec1-like_dom2"/>
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        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
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        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="597"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU46470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="665" mass="73855" checksum="8922C7BE4BF00F25" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQY0</accession>
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        <recommendedName>
            <fullName evidence="1">Protein AF-9 homolog</fullName>
        </recommendedName>
    </protein>
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        <name evidence="9" type="ORF">NECHADRAFT_38125</name>
    </gene>
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        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
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            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
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    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_38125"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="EDHTHQW"/>
    <dbReference type="OrthoDB" id="16041at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="YEATS_Yaf9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573:SF1">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF03366">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="YEATS" evidence="8">
        <location>
            <begin position="10"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022408"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU46098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="268" mass="30336" checksum="4224CD05AC284E34" modified="2009-10-13" version="1">MAPQNQLGKRVKLTQVRRPFIVGSTAKPFSDTNPRPAGIPDIHTHSWQVFVKGLDDTDITYWLRRVQFKLHESIPNYVRMVEGEPGKPFVVNETGWGEFDITLKLYYVNDSGEKPQTLYHYLRLHPYGRNEEEKQAMVASNGEIRAWSYEEQLFNEPYETFYNILTQGAVPKGWKPSGGKGKGKTRLPPPPPTDSNEVWERSAMIPAHNRPGQPFSLETEAAEIRKIADAQAQAEEMSKKILAELKSKEEMLAKLKAENQAAAAANKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRI8</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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            <taxon>Fusarium vanettenii</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003051134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YRI8"/>
    <dbReference type="GeneID" id="9667875"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_80405"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_80405"/>
    <dbReference type="HOGENOM" id="CLU_637914_0_0_1"/>
    <dbReference type="InParanoid" id="C7YRI8"/>
    <dbReference type="OMA" id="LTSCHER"/>
    <dbReference type="OrthoDB" id="5101385at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU45467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="430" mass="47325" checksum="565681BA6F95E98F" modified="2009-10-13" version="1">MPDKMTKLKKPKNTKEREPDEVKARGEEKEKKKKRHSQPPPPSAPSWVWWLAGGPNQRKKRSSHKSSSKEKSSSKKHSTKERSSDKKKTTTTTTTKRKKHREEESESEDDRDETNSAAGDLGVIDGENDYRMMPGQAKQSNKNHAWIDSRIGEHHSSVGIDRANLPMPPWHHRPTAQPYGGITYTPTNEERDPATRDQGVCPQEPRRQDAFQPPPVQNNYRSVGPQTTSQTSSTSTAHQQPPAPQNDVESTSQENSTGDVDQDHGTLPTIQEEPPRLTSRQSNTGPAEQEQSTTTAARDTTTGSGDGCGVTDKGGDEQESKEPASPQAGENEPKISDSTHMIAKKTEDSQVKEQAIESKKSVSPPVEENKPKISESTDTTAKAEDLQAKEQVIESNDSQGDQQESQGTDESRVNDNESAKSSQSSSCTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRR4</accession>
    <name>C7YRR4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RAD52 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_100571</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAD52 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051220.1">
        <property type="nucleotide sequence ID" value="XM_003051174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YRR4"/>
    <dbReference type="STRING" id="660122.C7YRR4"/>
    <dbReference type="GeneID" id="9666000"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100571"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100571"/>
    <dbReference type="eggNOG" id="KOG4141">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011431_4_0_1"/>
    <dbReference type="InParanoid" id="C7YRR4"/>
    <dbReference type="OMA" id="NLHRHAD"/>
    <dbReference type="OrthoDB" id="206565at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045002">
        <property type="term" value="P:double-strand break repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.80:FF:000001">
        <property type="entry name" value="DNA repair protein RAD52 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.80">
        <property type="entry name" value="DNA repair protein Rad52/59/22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004585">
        <property type="entry name" value="DNA_recomb/repair_Rad52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041247">
        <property type="entry name" value="Rad52_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007232">
        <property type="entry name" value="Rad52_Rad59_Rad22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042525">
        <property type="entry name" value="Rad52_Rad59_Rad22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00607">
        <property type="entry name" value="rad52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132">
        <property type="entry name" value="DNA REPAIR AND RECOMBINATION PROTEIN RAD52, RAD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04098">
        <property type="entry name" value="Rad52_Rad22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="261"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="263"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="280"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="419"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="504"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00077224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU45507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="524" mass="55741" checksum="9328231D24583E24" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C7YS52</accession>
    <name>C7YS52_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_40983</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050900.1">
        <property type="nucleotide sequence ID" value="XM_003050854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YS52"/>
    <dbReference type="FunCoup" id="C7YS52">
        <property type="interactions" value="479"/>
    </dbReference>
    <dbReference type="GeneID" id="9666143"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_40983"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_40983"/>
    <dbReference type="eggNOG" id="KOG0764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_6_1_1"/>
    <dbReference type="InParanoid" id="C7YS52"/>
    <dbReference type="OMA" id="AFYNGMG"/>
    <dbReference type="OrthoDB" id="10266426at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000075">
        <property type="entry name" value="Nicotinamide adenine dinucleotide transporter 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF1">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06780)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="51"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="156"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="281"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU45187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="43767" checksum="E28CE767FD88C12A" modified="2009-10-13" version="1">MSSHDQATSQASRSPSSEYAASSYSLPAASDAPMHSSTRVTPLHRWALNASDSQFNAISGAVGGFTSGIVTCPLDVIKTKLQAQGGYAALNRGRHVGHPKLYNGLIGSAKVIWREEGIRGLYRGLGPIVMGYLPTWAVYFTVYNKSKGWLSQHYDNSHLINLWSSITAGASSTIVTNPIWVIKTRLMSQSSVRHSHDHTSLYPKAGSTPTSRPTLHDWHYRSTIDAARKMYTSEGIISFYSGLTPALLGLSHVAVQFPTYEYLKTKFTGHSMGESAEGENANVVGILSASILSKIVASSATYPHEVIRTRLQTQRRPLAGEEVQRAQAQPPKYQGVIHTFQTILREEGWRAFYAGLGTNMMRAVPAATVTLLTYETVMSELLKTRAEARHLLLDSRTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSA4</accession>
    <name>C7YSA4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_93795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050929.1">
        <property type="nucleotide sequence ID" value="XM_003050883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSA4"/>
    <dbReference type="FunCoup" id="C7YSA4">
        <property type="interactions" value="1222"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YSA4"/>
    <dbReference type="GeneID" id="9668160"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_93795"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_93795"/>
    <dbReference type="eggNOG" id="KOG1301">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016216_2_0_1"/>
    <dbReference type="InParanoid" id="C7YSA4"/>
    <dbReference type="OMA" id="VNDLRAW"/>
    <dbReference type="OrthoDB" id="10251230at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035543">
        <property type="term" value="P:positive regulation of SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046578">
        <property type="term" value="P:regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="600"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="629"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU45216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="705" mass="76810" checksum="3FD767DA302872F0" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSB5</accession>
    <name>C7YSB5_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_93804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051319.1">
        <property type="nucleotide sequence ID" value="XM_003051273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSB5"/>
    <dbReference type="STRING" id="660122.C7YSB5"/>
    <dbReference type="GeneID" id="9666177"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_93804"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_93804"/>
    <dbReference type="eggNOG" id="ENOG502SI13">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031053_0_0_1"/>
    <dbReference type="InParanoid" id="C7YSB5"/>
    <dbReference type="OMA" id="VVCRNCT"/>
    <dbReference type="OrthoDB" id="5288318at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU45606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="487" mass="53471" checksum="7D2FD5351C73E7BE" modified="2009-10-13" version="1">MARFVDLDEEEDAGAGPAGGPRAGGARAHHEAAAPPPLPMPVPVPMPGQLQLQHDADPQLQQLSQKEQHLLLLKKLHLLSANGRNGPWSHSLYNPEPIGTMDSSTFRAPVTDAMQIYPIAVAVASSIDLNTLDALSRTCRLIHHGLLQYRTILLASTLHCRNESIPVDGSETFRYRARAGNWFYMEDGRSYNGKSGDCARDMVGECRRCGEVICRNCAIKPPAPVALRERHRRLCKPCVHAPIATLAKPPLDPDLPLSSEAVSRQICNCADACVWLCQPCGRSIRGADHEYQRIWRWRNQYGEVLGGLGTGIGEGDRGVICGREADCCAAKEREQQLDCDAEDARDGNVATPGGTTHPAPVDALIDELRLTHERTPSPSLGPGYLRHEIEGIGGIVKRKRVRMVRVGHCVPEWEDERGSGSRVLGREVRGVRRSWCGWCWRVIPGEKDYLNEPPSSSSSSSGGSRRTSTSTTRSNEFKLSRGELQDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSH6</accession>
    <name>C7YSH6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_93838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051352.1">
        <property type="nucleotide sequence ID" value="XM_003051306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSH6"/>
    <dbReference type="GeneID" id="9666205"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_93838"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_93838"/>
    <dbReference type="eggNOG" id="ENOG502T2GP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042091_1_1_1"/>
    <dbReference type="InParanoid" id="C7YSH6"/>
    <dbReference type="OMA" id="WTIPHIF"/>
    <dbReference type="OrthoDB" id="3432781at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025213">
        <property type="entry name" value="Sim4_Fta2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13095">
        <property type="entry name" value="FTA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU45639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="40783" checksum="D7D1D88761063046" modified="2009-10-13" version="1">MPALIPLPLGDGPKLQPFSYNLLSDDVEFLEFLGHHGVHGIIVKTRIRGRIYAIKFFTETEMSEPEYSASDYPTIPREKAAEFESHFTPFYQECRAYGRLKEVNCEYLAVKVYGYVSLKVDQALERKMRNALLKLYRIVKDWVEPARYWRETDIPSHRIDSILSVSHFPRMLEDLHEIHRCGIVIRDMSISQYVNGVLVDFSMAWTMPHPFGPGGLGLEPTWKFQSLAAWDLYCFQTKVIDVWNNYLRYVLGTMQRECRLQAYRHPAPYMLRPQPSRQRPFLPITNDEWIDLDMIDLPRHDPGAFNVDVVRKQNKRKRAERRTKIKDGTSSLEPWEGRRALDPGWFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7YTI6</accession>
    <name>C7YTI6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_48741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050339.1">
        <property type="nucleotide sequence ID" value="XM_003050293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YTI6"/>
    <dbReference type="STRING" id="660122.C7YTI6"/>
    <dbReference type="GeneID" id="9674732"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_48741"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_48741"/>
    <dbReference type="eggNOG" id="ENOG502S8V4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057546_2_0_1"/>
    <dbReference type="InParanoid" id="C7YTI6"/>
    <dbReference type="OMA" id="LSWWDFF"/>
    <dbReference type="OrthoDB" id="9988524at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF10">
        <property type="entry name" value="PROTEIN PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="1">
        <location>
            <begin position="164"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU44626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="290" mass="33053" checksum="FB4EB789C2A099F0" modified="2009-10-13" version="1">MSSNVGLESVLNFRDVGKTVNDFLGTRRLREGVFYRSARLDDATLLDRKLIRDGLGIKTAIDLRTKTEHLNRVKRRQEQSNIPALVKSNAALAEPLHIPGLEYREIKITGRPFELFLLRQLSWWDLFHFLFLFLCGYRMEAINILGQNVMIPRGVVGLGLDTLDQSTREIRETLSLYTAETNLPSVVHCTQGKDRTGLVCTLVLMILDVPVSAIEHDYRLTDEALIPEREERLVEIRQIGLSDEWADTAKDMIVRIEQHLNEKYGGLDAYLDGIGFGADDRARVRDALLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7YUP6</accession>
    <name>C7YUP6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_49128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050159.1">
        <property type="nucleotide sequence ID" value="XM_003050113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YUP6"/>
    <dbReference type="GeneID" id="9674944"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_49128"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_49128"/>
    <dbReference type="eggNOG" id="ENOG502RK0Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060983_1_0_1"/>
    <dbReference type="InParanoid" id="C7YUP6"/>
    <dbReference type="OMA" id="AEDPRMY"/>
    <dbReference type="OrthoDB" id="3012298at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06546">
        <property type="entry name" value="GH18_CTS3_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF60">
        <property type="entry name" value="III CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="2">
        <location>
            <begin position="12"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU44446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="342" mass="37998" checksum="25F7E2ECD64F717A" modified="2009-10-13" version="1">MPPLPTSSNPLPRLITYYQTHHDSSGNLISPLPLITQPGITITHVIVAAIHINDKPQDITLNNHHPSHPRFQTMWAELRVLQASGVKVMGMLGGAAKGSYQRLDADQEQFDRFYGPVRDMIRERGLDGLDLDVEEEMSLGGIVRLIDRLRSDFGPSFIITLAPVAMSLLDFTKNLSGFDYEALEVMRGRDIAWYNTQFYCGWGDCSNPLMYDLMIQKGWPPEKIVIGLVTNPENGGGYVPMNPLSMVLTTLRGRYGSFGGIMGWEYFNSLPGGTARPWEWARDMTKLLRGQLFPQSAETAVVTDGSTPKAHATDEIDADAPGGKDVKVPKQFDYYSDGTDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7YV02</accession>
    <name>C7YV02_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_85103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050209.1">
        <property type="nucleotide sequence ID" value="XM_003050163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YV02"/>
    <dbReference type="GeneID" id="9674994"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85103"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85103"/>
    <dbReference type="eggNOG" id="ENOG502T3GR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_987080_0_0_1"/>
    <dbReference type="InParanoid" id="C7YV02"/>
    <dbReference type="OMA" id="RRESEMN"/>
    <dbReference type="OrthoDB" id="5953249at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="2">
        <location>
            <begin position="88"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU44496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="347" mass="40897" checksum="B6E9DB00645AEF9E" modified="2009-10-13" version="1">MSTSSESTWSDQEGLFSGESQSHIPPFRCGHLRAQAPEGLDNVLPVIDPRNSFRFNKRPTTDYVLVALDFEHLCKTKIGRYADGTRYRYNPLTEAGVAYLDMRNVLYKKGRWTMPGDRGHSWFKLMTPLHYIVEEYKGHWGHLCKSDWLHVEPYMFAFGKSKIVKEGELGYRLYRLFMGLRKMNRRRDEIRHNRLREIIFLTFDSSPVENTLSRLGLGWLTEPNIKIWDVQRDMQLELRFNWPKMRFEYVMESLGLRFEDNRFGNLSHCAGNAAVFTIQIFLALFYKDDEQSVAFAAREPMSWLRFTWVGHALDQTNIAPGDSPRRREESQMNRHEVPQKRDENAFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVQ6</accession>
    <name>C7YVQ6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Delta 8-(E)-sphingolipid desaturase</fullName>
            <ecNumber evidence="5">1.14.19.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">NECHADRAFT_30435</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.18" evidence="5"/>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049752.1">
        <property type="nucleotide sequence ID" value="XM_003049706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVQ6"/>
    <dbReference type="STRING" id="660122.C7YVQ6"/>
    <dbReference type="GeneID" id="9677327"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_30435"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_30435"/>
    <dbReference type="eggNOG" id="KOG4232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016265_3_1_1"/>
    <dbReference type="InParanoid" id="C7YVQ6"/>
    <dbReference type="OMA" id="HWGMSTS"/>
    <dbReference type="OrthoDB" id="260091at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF30">
        <property type="entry name" value="DELTA 8-(E)-SPHINGOLIPID DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="17">
        <location>
            <begin position="4"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEU44039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="555" mass="63542" checksum="E6783D8794AD3077" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVX5</accession>
    <name>C7YVX5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_30239</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU43864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049577.1">
        <property type="nucleotide sequence ID" value="XM_003049531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVX5"/>
    <dbReference type="STRING" id="660122.C7YVX5"/>
    <dbReference type="GeneID" id="9677152"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_30239"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_30239"/>
    <dbReference type="eggNOG" id="KOG0585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004329_0_0_1"/>
    <dbReference type="InParanoid" id="C7YVX5"/>
    <dbReference type="OMA" id="HRVRETH"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000614">
        <property type="entry name" value="Serine/threonine protein kinase, putative"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Serine/threonine-protein kinase Ssp1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
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    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE TOS3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="131"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="314"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="711"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="798"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="928"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="978"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1159"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="352"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="711"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="721"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="809"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="831"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="861"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="876"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="997"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1025"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1051"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1235"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU43864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1245" mass="138359" checksum="42894D07596D44ED" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWD3</accession>
    <name>C7YWD3_FUSV7</name>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_98573</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003049828.1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98573"/>
    <dbReference type="eggNOG" id="KOG2128">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000972_1_1_1"/>
    <dbReference type="InParanoid" id="C7YWD3"/>
    <dbReference type="OMA" id="KGVLVHW"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
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    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:actin filament binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:calmodulin binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:1903479">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly actin filament organization"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="CH_IQGAP"/>
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        <property type="entry name" value="RasGAP_IQGAP_like"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
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        <property type="entry name" value="Rho_GTPase_activation_prot"/>
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        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="IQ"/>
        <property type="match status" value="8"/>
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        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
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        <location>
            <begin position="303"/>
            <end position="409"/>
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    </feature>
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        <location>
            <begin position="1053"/>
            <end position="1269"/>
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    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
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        <location>
            <begin position="817"/>
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        <location>
            <begin position="1"/>
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    </feature>
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        <location>
            <begin position="38"/>
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        <location>
            <begin position="55"/>
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    </feature>
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        <location>
            <begin position="73"/>
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    </feature>
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        <location>
            <begin position="96"/>
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        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="EEU44161.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1689" mass="193618" checksum="CB2A0BA6A0BA309A" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWJ3</accession>
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        <recommendedName>
            <fullName evidence="8">Histone chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="9" type="ORF">NECHADRAFT_65288</name>
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    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
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        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms a heterotrimer with H2A.Z-H2B, stabilizing the association of the histone dimer. Also, with a lower affinity, forms a heterotrimer with H2A-H2B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CHZ1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU43967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049680.1">
        <property type="nucleotide sequence ID" value="XM_003049634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWJ3"/>
    <dbReference type="STRING" id="660122.C7YWJ3"/>
    <dbReference type="GeneID" id="9677255"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_65288"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_65288"/>
    <dbReference type="eggNOG" id="ENOG502SCUM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130004_1_0_1"/>
    <dbReference type="InParanoid" id="C7YWJ3"/>
    <dbReference type="OMA" id="MEGVQDP"/>
    <dbReference type="OrthoDB" id="2148987at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019098">
        <property type="entry name" value="Histone_chaperone_domain_CHZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09649">
        <property type="entry name" value="CHZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01082">
        <property type="entry name" value="CHZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone chaperone" evidence="8">
        <location>
            <begin position="62"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="88"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU43967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="118" mass="12849" checksum="0C90D08894E63A84" modified="2009-10-13" version="1">MAENSATIPQDPSKIQEDSVAESKGKGAAAPENIHEDTAMDEDDDDDDSDEDEEVCAAAIYEDGMEEIDLNNIVEGGRRTRGAVIDFAKAAEQHPAAEDEDEEDDDDFQPTEDVKMSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWK5</accession>
    <name>C7YWK5_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_89827</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049910.1">
        <property type="nucleotide sequence ID" value="XM_003049864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWK5"/>
    <dbReference type="FunCoup" id="C7YWK5">
        <property type="interactions" value="232"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YWK5"/>
    <dbReference type="GeneID" id="9674522"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89827"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89827"/>
    <dbReference type="eggNOG" id="KOG0132">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016577_0_0_1"/>
    <dbReference type="InParanoid" id="C7YWK5"/>
    <dbReference type="OMA" id="GIVQTCI"/>
    <dbReference type="OrthoDB" id="79367at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031126">
        <property type="term" value="P:sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16984">
        <property type="entry name" value="CID_Nrd1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000026">
        <property type="entry name" value="RNA binding protein Nrd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000397">
        <property type="entry name" value="RNA binding protein Nrd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048892">
        <property type="entry name" value="Nrd1_Seb1_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21380">
        <property type="entry name" value="Nrd1-Seb1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CID" evidence="10">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="474"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="150"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="205"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="334"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="602"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="448"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="626"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="659"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU44197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="702" mass="75047" checksum="5B1318BB6E11FE34" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYK8</accession>
    <name>C7YYK8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_46703</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048921.1">
        <property type="nucleotide sequence ID" value="XM_003048875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYK8"/>
    <dbReference type="GeneID" id="9665918"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_46703"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_46703"/>
    <dbReference type="eggNOG" id="ENOG502RF8N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015502_0_1_1"/>
    <dbReference type="InParanoid" id="C7YYK8"/>
    <dbReference type="OMA" id="WDLFIID"/>
    <dbReference type="OrthoDB" id="5367487at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU43208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="609" mass="67307" checksum="7C3FF3190FCB183B" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYW9</accession>
    <name>C7YYW9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_71135</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048786.1">
        <property type="nucleotide sequence ID" value="XM_003048740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYW9"/>
    <dbReference type="GeneID" id="9665633"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_71135"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_71135"/>
    <dbReference type="eggNOG" id="KOG1591">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011017_1_1_1"/>
    <dbReference type="InParanoid" id="C7YYW9"/>
    <dbReference type="OMA" id="TRAAMSC"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF10">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="11">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="646"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="711"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="720"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="735"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU43073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1080" mass="120209" checksum="A8BA6C8563A580F7" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYX7</accession>
    <name>C7YYX7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Brix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_47234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048985.1">
        <property type="nucleotide sequence ID" value="XM_003048939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYX7"/>
    <dbReference type="FunCoup" id="C7YYX7">
        <property type="interactions" value="893"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YYX7"/>
    <dbReference type="GeneID" id="9665636"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_47234"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_47234"/>
    <dbReference type="eggNOG" id="KOG2780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040063_3_2_1"/>
    <dbReference type="InParanoid" id="C7YYX7"/>
    <dbReference type="OMA" id="HFSVSNW"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000005">
        <property type="entry name" value="Similar to RNA processing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF3">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="178"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU43272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="412" mass="47558" checksum="6381BDD56ECC158C" modified="2009-10-13" version="1">MGFTKPPVQALKSANKIKRRELFVQHKKHRDKERHEERHRRRREEAKDPELKAARLAKRKPVTIDQKRVWDDVDDDSLGAQVDLEKLKRRRIEEAEAAEQAAHEAEMQEDDDDDDVDSMLASDEEMDEERQAALDKKREKRARRDNSIAPSTTSTNLDLTPSSLALKFPALFTDIPPPVPKILITTSLNSTIHEEAHLLCGLFPNSNYIPRSAHRYGHKYSLREICKYASNREYTAVVLLKEDSKKPTGLSVVHLPTGPTFHFSITNWIEGKKLPGHGNPTNHYPELLLNNFKTPLGLLTAKLFQTMFPPRPEFQGRQVVTLHNQRDYIFVRRHRYVFRDKRQTEKSIVGADGKEIKGVENIRAGLQELGPRFTLKLRRVDKGIGRAGSEGEDATQWEWKAKMEKDRKRFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZS1</accession>
    <name>C7YZS1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_47388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048561.1">
        <property type="nucleotide sequence ID" value="XM_003048515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZS1"/>
    <dbReference type="GeneID" id="9667447"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_47388"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_47388"/>
    <dbReference type="eggNOG" id="ENOG502SJDN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034451_1_0_1"/>
    <dbReference type="InParanoid" id="C7YZS1"/>
    <dbReference type="OMA" id="VVWGANH"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.110">
        <property type="entry name" value="acylaminoacyl peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010520">
        <property type="entry name" value="FrsA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF12">
        <property type="entry name" value="CONIDIAL PIGMENT BIOSYNTHESIS PROTEIN AYG1 (AFU_ORTHOLOGUE AFUA_2G17550)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06500">
        <property type="entry name" value="FrsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988396" description="AB hydrolase-1 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU42848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="47981" checksum="9DFE944BD6A3ECC2" modified="2009-10-13" version="1">MKFSHSLLLTALGVSSCAAAEDLRDEHPVLLLSEDESFHFELLVPLEQAIGGGSDINPVLLAAKNITPGDLDSFSEVFYQLANETKAQAEDPEFAYDPINVRDAWFSAATYFRRADFYLHSDWEDPLINSLWEEQTAAFNKGMASLPHPGKRIRVKADNFTVEAIWYTESEHSLRPTIIMGNGYDGAQEDLYHIVVTGALARGWNVLTYEGPGHPSVRRNQNLGFIPDWERVVTPLVDYLLNEKAAAVDSEKLALFGYSFGGYHAARAAAFEPRIKAVLCNGGVWDTYESFSSGLTPEMKELLESGNKEEFDKIAEKLRKDPSTPTTFRWGMNQGLWSFNVRSPYDFMQLTKQHTLKDVVHRIKAPVWIADAEFEGFFRGQSAKVKKALGEQADLHVFRGAAGYHCQTGAGQEMMRVMFAWLHKTLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0L2</accession>
    <name>C7Z0L2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase family 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_79931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048114.1">
        <property type="nucleotide sequence ID" value="XM_003048068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0L2"/>
    <dbReference type="FunCoup" id="C7Z0L2">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z0L2"/>
    <dbReference type="GeneID" id="9671920"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79931"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79931"/>
    <dbReference type="eggNOG" id="KOG1950">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034860_2_1_1"/>
    <dbReference type="InParanoid" id="C7Z0L2"/>
    <dbReference type="OMA" id="VPKPWIN"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU42401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="51100" checksum="86A4EC378E91CF72" modified="2009-10-13" version="1">MSRLLRFLPSLIFLSIFFCFLLNLFEYDYPDVPIPDTWRDHRVEIPESAGRSGGYPGSPSFMGGENLEAQDNDGHGNAFVGNGKPSEGEERAVSEVDIDDSEFHDDSVDENDEIEEEENVTESADSDIIDWSRFAYVQYVTNDVYLCNSLMIFEALQRFGSNAERLMMYPGHMLAPDAQESGTHAGQLLIKARDQYKVKLRPVEIQRRNGNDVTWAESFTKLLAFNQTQYDRVISLDSDGVVLQHMDELFQLPPCRVAMPRAYWFMKDDPPKTMLASHVMVVEPDKIEMERIFKKIETIENTEYDMEVINSLYLDSAMIIPHRPYGLLSAEFRMKDHSQYLGSKKEEWDAIGVLAEAKYVHFSDWPVPKPWVQDSAMRLQKQPQCPTADGQGTQETCVEREIWNRLYTDFAENRKRICEPVGKPQRRKWFNWNRLDRVESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0S5</accession>
    <name>C7Z0S5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_104321</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047964.1">
        <property type="nucleotide sequence ID" value="XM_003047918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0S5"/>
    <dbReference type="GeneID" id="9671949"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_104321"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_104321"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_0_1"/>
    <dbReference type="InParanoid" id="C7Z0S5"/>
    <dbReference type="OMA" id="KSYLAMP"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF12">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="72"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU42251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="576" mass="63166" checksum="43747748F01B0DA6" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1C6</accession>
    <name>C7Z1C6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Conidiophore development protein hymA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_40421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mo25 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048260.1">
        <property type="nucleotide sequence ID" value="XM_003048214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1C6"/>
    <dbReference type="FunCoup" id="C7Z1C6">
        <property type="interactions" value="383"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z1C6"/>
    <dbReference type="GeneID" id="9667225"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_40421"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_40421"/>
    <dbReference type="eggNOG" id="KOG1566">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035755_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z1C6"/>
    <dbReference type="OMA" id="AYDHKES"/>
    <dbReference type="OrthoDB" id="609103at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071958">
        <property type="term" value="C:new mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035839">
        <property type="term" value="C:non-growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071574">
        <property type="term" value="P:protein localization to medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000100">
        <property type="term" value="P:regulation of establishment or maintenance of bipolar cell polarity regulating cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000257">
        <property type="entry name" value="Conidiophore development protein hymA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013878">
        <property type="entry name" value="Mo25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182:SF3">
        <property type="entry name" value="PROTEIN MO25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08569">
        <property type="entry name" value="Mo25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="42223" checksum="CD9A6C0B8C68E7D0" modified="2009-10-13" version="1">MSFLFGRARTRTVADLPKQAREHISKLEGPNGASKAEELARVLSQMKVILQGTHADSSPEQIYQLVTGLIDEDLLHLLAVNLFRLPFESRKDTQVIFSYVFRFRPATAAPKSDPIALSYVVCNRPQVLVELCRGYDHKESATPAGSVLRELLKNEAAAAIILYDDGDEPGSSSKGLNAIDRERPQSGRGVFWRFFDWVDKSSFEVAADAFTTFRELLTRHKDLVPRYLSANFDLFFDKYNNILVQSNSYVTKRQSIKLLGEILLDRSNYSVMTAYVDRGEHLKICMNLLRDDRKMVQYEGFHVFKVFVANPHKSIAVQKILLMNREKLLTFLSHFLEDRTDDEQFIDEREFLIKQIRNMPPMPVAPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z263</accession>
    <name>C7Z263_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_96949</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU42116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047829.1">
        <property type="nucleotide sequence ID" value="XM_003047783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z263"/>
    <dbReference type="STRING" id="660122.C7Z263"/>
    <dbReference type="GeneID" id="9671797"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_96949"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_96949"/>
    <dbReference type="eggNOG" id="ENOG502QQXX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006632_1_1_1"/>
    <dbReference type="InParanoid" id="C7Z263"/>
    <dbReference type="OMA" id="YPLTFHM"/>
    <dbReference type="OrthoDB" id="2264294at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="54"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU42116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="729" mass="82600" checksum="4C1F049270D2BE47" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z287</accession>
    <name>C7Z287_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_50968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU42130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047843.1">
        <property type="nucleotide sequence ID" value="XM_003047797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z287"/>
    <dbReference type="STRING" id="660122.C7Z287"/>
    <dbReference type="GeneID" id="9671807"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_50968"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_50968"/>
    <dbReference type="eggNOG" id="ENOG502R9AJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041041_1_1_1"/>
    <dbReference type="InParanoid" id="C7Z287"/>
    <dbReference type="OMA" id="HNDMGCD"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF54">
        <property type="entry name" value="FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="161"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU42130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="368" mass="40504" checksum="22F746FFDB285757" modified="2009-10-13" version="1">MATLRGMTQDSAEAVQSIQEKILAGLNSDLAGISVKASSDALAGPLVWSGAEFQGDSTYTLRLSEDEVAEIDNALAKFKTLGLDGDEVSRDNFPLPNLSRRLRSSSETLHMGRGFVVIRGLEASKYTVEDSVTVFLGVASYIAEKRGRQDRKGNMLCKSTPYAEKGGYTYLSSAWTVFNDLLNREPEVVKTLLTPNWPVQLSGRKASYYLAPVFSFHDGKLLASLDPARLGPHPSMANNTNIPSLTEDQVHALQSVSEAASQSEVRLELQTGDLLFFNNLALVHRRDAYSDDASSSRHMVRLWLRSQKLGWAIPDGMLPPWEAAYGESRKKNKPALYPIVPAVEYPVQKYTTSSAAFMIEDSESSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z2G3</accession>
    <name>C7Z2G3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_87592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047369.1">
        <property type="nucleotide sequence ID" value="XM_003047323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z2G3"/>
    <dbReference type="GeneID" id="9676360"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87592"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87592"/>
    <dbReference type="eggNOG" id="ENOG502R141">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_855427_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z2G3"/>
    <dbReference type="OMA" id="HESFEQD"/>
    <dbReference type="OrthoDB" id="5403091at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU41656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="327" mass="37121" checksum="7D91424302788194" modified="2009-10-13" version="1">MSQSTIKPQVNHDVAFRHEVLEGFLSDLHDVSTTKDKQELLTSIQSFAFQFLKDASNKELTRHGQVDQGLEVLWRMFIEMAKVLEKDDPFHDKLVLLLLWTKEFDQLHKDLHPSDSVKAFWESYGFGNSLQKSWEQTLSSGTSSQLCNLAAFSTKALSAGVCQDTLALTALWYLREALEKGEEGVTANLLPAAVMWVDQCRHRLLTFSILDRSYEAHPRSDLSACGALTRAKGVNRSGGFSIERWLFWRERFQHLSHSQDSSVAKEAKRGFMTMINCGRDLGYEVPGEARFAERLQKAMWEALVESGKESLDGDEIDIKVDWADEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z2T2</accession>
    <name>C7Z2T2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_87709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047430.1">
        <property type="nucleotide sequence ID" value="XM_003047384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z2T2"/>
    <dbReference type="STRING" id="660122.C7Z2T2"/>
    <dbReference type="GeneID" id="9671446"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87709"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87709"/>
    <dbReference type="eggNOG" id="ENOG502REK9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_588042_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z2T2"/>
    <dbReference type="OMA" id="ECEAFRI"/>
    <dbReference type="OrthoDB" id="59699at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU41717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="52197" checksum="3D3A3D1647202053" modified="2009-10-13" version="1">MTSYYGHRASPVNLNAPNDDYSQDVDTSKIVVDAPTFTNLPESCDKFRILVIGKAGTGVSHRTVGTKREKVWHPITFPGENENLVLHDSGGFEAGDLKCVDEIHSFIKYRREQPNLADQLHCIWYCISCRSNRPIESAEKEFFLNADVGDIPVVVVFTQFDTLVDDHFCKLLRRRQRTRGKAVDMEQLERDAMNAAIADYDSDYRGQFEREFGRRLRVAIIRLSMPQTDDGEPLETTGVDSLVKETRGMLLEDGLKLLWTAAQCHSADMKLKESIKLGMDVFWKAVGTSSIPFIPFVGATAIYSAFIKILKTINTIWGIPSCTPLLHDSKVRNLFLQGCFDASAGDILGSKFLMALNFFGPLTAAQTATIILKMIAGISLIYEKLFWYIKNHPDRVVSPATIGRMVTEFRRSQGQRNMSARLTFRIHLGNCYDKAACLAELEEAVEAGRSAMGKEGMRKKTIVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z2Z1</accession>
    <name>C7Z2Z1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_54303</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047281.1">
        <property type="nucleotide sequence ID" value="XM_003047235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z2Z1"/>
    <dbReference type="GeneID" id="9675886"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_54303"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_54303"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z2Z1"/>
    <dbReference type="OMA" id="PEKRCKF"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000059">
        <property type="entry name" value="N-ethylmaleimide reductase, FMN-linked"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF93">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="4">
        <location>
            <begin position="12"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU41568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="407" mass="45565" checksum="2466659798631394" modified="2009-10-13" version="1">MGDALDVGPASKLFQPLDIANGKIRLKHRVILAPLTRNRGTPLNANSTPENPNRVWVPNDLMLEYYTQRTTDRGLIISEGLPPSLEGNGMPGVPGIFLSEQAEGWKKIVDAVHAKGGFIYAQLWHSGRANIPQLTGTPIVAPSAVTWDDPNETFSYPAPHSTTPVKLADHPPIELTVDHIKKTIDDYRKAAKTAMDIGFDGVELHAGNGYLPEQFLSTNINKRTDDYGGTAEKRCKFPLELMEELAKTVGQENLAIRLTPFGLFNQARSEQRVETWGHLCRELKARLPNLSYVSFVEPRYEQIFSEAEKQEFLNSWGLPTVDLSLFRSIFGDTPFFSAGGFDDENSWGVLESGKYDGLLYGRYFISNPDLVERLRNGWPLAPYDRSRFYGPFEDSTIGYTDYPAYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z3S4</accession>
    <name>C7Z3S4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_46030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047072.1">
        <property type="nucleotide sequence ID" value="XM_003047026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z3S4"/>
    <dbReference type="STRING" id="660122.C7Z3S4"/>
    <dbReference type="GeneID" id="9675482"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_46030"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_46030"/>
    <dbReference type="eggNOG" id="ENOG502QSAC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032323_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z3S4"/>
    <dbReference type="OMA" id="THMTSHR"/>
    <dbReference type="OrthoDB" id="2283785at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039634">
        <property type="entry name" value="Bul1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904:SF1">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU41359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="403" mass="44584" checksum="8DD3427B5E1CD66D" modified="2009-10-13" version="1">MTPPEYDHIGIRRGGTSHPWGLASNALSILRARAKKTEVNVSINGHFNSKVYTTDSEVSGNVTISPSRNMQFDRVDISLIGSGETRRDGPDITHLTTHRFLRLEMPIDDDEYPANHVFEAGKGYTFAFNFNIPAHLTSQACIHRIESDHVWEKHMCLPPTVGGWEKDDLAPEMARISYSIKACVLKKSKQGPVVISESSHPINVMPSTFEEPPLSITKGDDLYALERTKNVRKNMFSAVQGRISAVAAEPAAIHLSKEGHEASPSTIPVSLTFEPSAADVIPPQFTSASIKIQAHTWFRDQPMTRLPNLGGQTDNFAYPASVSLRKTKASVEWTQNVDMEQSDKGSPIFHTATIQVPFKLPTADKMFIPTFNSCIIARAYTARLVLEGDTKMELTVPVQVVMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z3W8</accession>
    <name>C7Z3W8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Septum-promoting GTP-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_104949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047089.1">
        <property type="nucleotide sequence ID" value="XM_003047043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z3W8"/>
    <dbReference type="FunCoup" id="C7Z3W8">
        <property type="interactions" value="543"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z3W8"/>
    <dbReference type="GeneID" id="9678667"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_104949"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_104949"/>
    <dbReference type="eggNOG" id="KOG1673">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z3W8"/>
    <dbReference type="OMA" id="FDLNCTI"/>
    <dbReference type="OrthoDB" id="6585768at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040001">
        <property type="term" value="P:establishment of mitotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031578">
        <property type="term" value="P:mitotic spindle orientation checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904750">
        <property type="term" value="P:negative regulation of protein localization to nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031536">
        <property type="term" value="P:positive regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023056">
        <property type="term" value="P:positive regulation of signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902542">
        <property type="term" value="P:regulation of protein localization to mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04128">
        <property type="entry name" value="Spg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017231">
        <property type="entry name" value="Small_GTPase_Tem1/Spg1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037527">
        <property type="entry name" value="Small_GTPase_Tem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU41376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29348" checksum="77707F14452095AA" modified="2009-10-13" version="1">METEVPPPHEVPDDTLGGIEGSPHVASSSNGFRHQQSTSLDQGLANSPKPEEDPSARYTPPVQPAPPISRPASGLSNPAHQAYNDYRQGAGEPSSNGRNHVVIKVGMVGDAQIGKTSLMVKYVEGSWDEDYIQTLGVNFMEKTISIRNTEITFSIWDLGGQREFVNMLPLVCNDAVAILFMFDLTRKSTLNSIKEWYRQGRGFNKTAIPILVGTKYDHFVNFPPQDQEEISNQIFKIVLSKAFDLKCTIPEIENVGEPLLLYQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z449</accession>
    <name>C7Z449_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_83480</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046968.1">
        <property type="nucleotide sequence ID" value="XM_003046922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z449"/>
    <dbReference type="GeneID" id="9675615"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83480"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83480"/>
    <dbReference type="eggNOG" id="KOG2615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_54_5_1"/>
    <dbReference type="InParanoid" id="C7Z449"/>
    <dbReference type="OMA" id="PQIMLLI"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU41255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="430" mass="45633" checksum="6338E0237C4A679C" modified="2009-10-13" version="1">MVKDMKPTANDNEVAQILTLIFSAYSFAQFATNLLWGRVSDSIGRRPVVLIGLASTCVSMLGLGLSRSIPAMFVFRVMAGSLSGNIVIVRTVIGEIVHGRENKARAFVWNQTVYQVGSVLGPLVGGYLAQPCRQFPEMCDANSLLYTYPFALPNLALSAMAALSFAVAFFLVEESLEKPDDRKIMGGEDDESTALLSAHEPPRSPSFRDAISSKVIHVVLSYALMALHTICFDQIFPVFMVTSRAASHPPFYLDGGLGFESSLAASLISAAGIVFVCLMITVFPVVDRWLGSLLCLQGSVMIYPITYLLLPYLSVLPASPAWIPITGASTILLAKAVAAVFSFNENSVLLSMASPSRNTLGIVNGIGQTAAAGARALGPAAMGIFIGLGDRVGSGALGWWFLAAVAAVGALQGLWVVDEPDEPSNEADSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z515</accession>
    <name>C7Z515_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphoribosylformylglycinamidine synthase</fullName>
            <ecNumber evidence="4">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Formylglycinamide ribonucleotide amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Formylglycinamide ribotide amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">NECHADRAFT_66683</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the FGAMS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="4"/>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU41021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046734.1">
        <property type="nucleotide sequence ID" value="XM_003046688.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="C7Z515">
        <property type="interactions" value="974"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z515"/>
    <dbReference type="GeneID" id="9678261"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_66683"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_66683"/>
    <dbReference type="eggNOG" id="KOG1907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001031_0_2_1"/>
    <dbReference type="InParanoid" id="C7Z515"/>
    <dbReference type="OMA" id="LSANWMW"/>
    <dbReference type="OrthoDB" id="6666987at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01740">
        <property type="entry name" value="GATase1_FGAR_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02203">
        <property type="entry name" value="PurL_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02204">
        <property type="entry name" value="PurL_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000002">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000005">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000008">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000005">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000024">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.750">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00419">
        <property type="entry name" value="PurL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040707">
        <property type="entry name" value="FGAR-AT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055181">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010073">
        <property type="entry name" value="PurL_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01735">
        <property type="entry name" value="FGAM_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003672">
        <property type="entry name" value="PRK05297.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18076">
        <property type="entry name" value="FGAR-AT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22689">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13507">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01211">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109736">
        <property type="entry name" value="FGAM synthase PurL, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="PurS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase N-terminal" evidence="20">
        <location>
            <begin position="38"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase linker" evidence="19">
        <location>
            <begin position="178"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="18">
        <location>
            <begin position="441"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="FGAR-AT PurM N-terminal-like" evidence="21">
        <location>
            <begin position="678"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="18">
        <location>
            <begin position="882"/>
            <end position="1015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00057317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF18076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF22689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EEU41021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1355" mass="147967" checksum="6D3E0BF8D8EBC35F" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z540</accession>
    <name>C7Z540_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_76738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046167.1">
        <property type="nucleotide sequence ID" value="XM_003046121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z540"/>
    <dbReference type="GeneID" id="9678273"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76738"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76738"/>
    <dbReference type="eggNOG" id="ENOG502RJAU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1098752_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z540"/>
    <dbReference type="OrthoDB" id="5085888at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="67"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU40454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="253" mass="28549" checksum="233A3DD18890F556" modified="2009-10-13" version="1">MPAQAHRPSSRIFHRAHLLFFCICTNIANFDSLHLHHLRDSSAPVLKMTMNNAFGTPSSFSTPSQRERDLADELKGAKEEIQAKNQRELELLSQLLEAKTCLLQTSQQREQRLTTQFQKVKADLETTQQHEKTLTAQLEKWKSDCEKAQTREKDTATQVQLLKKTLDATREREGLANADLAKIKAELGLSKTREKNLNIEIEQLKQDLEANNGQAQTPGFKRARTDSWGPPAHTPTSSKRGGRGGAHGQFRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z5B0</accession>
    <name>C7Z5B0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_32854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU41066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046779.1">
        <property type="nucleotide sequence ID" value="XM_003046733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z5B0"/>
    <dbReference type="GeneID" id="9678311"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_32854"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_32854"/>
    <dbReference type="eggNOG" id="ENOG502SVBJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_489187_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z5B0"/>
    <dbReference type="OMA" id="WSIQTWI"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="470"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU41066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="560" mass="62640" checksum="B7F31A040EEAA9CA" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z680</accession>
    <name>C7Z680_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Quinate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_33844</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046364.1">
        <property type="nucleotide sequence ID" value="XM_003046318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z680"/>
    <dbReference type="GeneID" id="9667924"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_33844"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_33844"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="InParanoid" id="C7Z680"/>
    <dbReference type="OMA" id="RRIQWRF"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF34">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="24"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU40651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="546" mass="60861" checksum="2F5E74FDE93A5445" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6C3</accession>
    <name>C7Z6C3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane adaptor Erv26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_33233</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SVP26 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046380.1">
        <property type="nucleotide sequence ID" value="XM_003046334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6C3"/>
    <dbReference type="FunCoup" id="C7Z6C3">
        <property type="interactions" value="251"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z6C3"/>
    <dbReference type="GeneID" id="9668655"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_33233"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_33233"/>
    <dbReference type="eggNOG" id="KOG4136">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058268_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z6C3"/>
    <dbReference type="OMA" id="TMGTEPV"/>
    <dbReference type="OrthoDB" id="28257at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097020">
        <property type="term" value="F:COPII receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007277">
        <property type="entry name" value="Svp26/Tex261"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13144:SF0">
        <property type="entry name" value="PROTEIN TEX261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13144">
        <property type="entry name" value="TEX261 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04148">
        <property type="entry name" value="Erv26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU40667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="23658" checksum="36F75797EBA8EFAB" modified="2009-10-13" version="1">MWILPLVGYAGTFMGFCFLTLAIASGLYYLSELVEEHSVIAKRFLTRLIYSIIVIQIILWLVDGFPFGATVLTIVSHVIYLGNMRRFPFVKLSDPLFILSCVLVLVNHYVWFRHFSDTQARAYQRTSYYDKADVPSFAQIASYFGLCVWLVPFALFVSLSAGDNVLPTMGTEPAHGFDGKSKPQGMIKALVDQIRGAIGQIFGSSASPGLGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6C8</accession>
    <name>C7Z6C8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_76057</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046382.1">
        <property type="nucleotide sequence ID" value="XM_003046336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6C8"/>
    <dbReference type="GeneID" id="9668658"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76057"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76057"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_6_1"/>
    <dbReference type="InParanoid" id="C7Z6C8"/>
    <dbReference type="OMA" id="MRWMLVR"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="64"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU40669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="491" mass="54299" checksum="E7F95F2B79DAC783" modified="2009-10-13" version="1">MTAPRDQEKMSENIQALDAEKQNSAHQEYSSEVLDKKTNGDYSGATAKTDPEEIKLVKKLDLWIMPTLWFMYWLNYLDRNAITLARLNGFEEDLGLKGSQYNTAVSILFVGYTLGQIPSNMIITRVRPSWYMGGFMMAWAVVSALTAVAHNYTGALLTRFFLGIVEAPYYPGALYTLSTFYTRKELATRISILYSGNVLASAFAGLIAAGVFEGMDGLAGIKGWRWLFILQGAVTVLVAIVACFTLPDEPLTTRWLTPEQRQLAHDRVQRDTVGGKGNGNPWSGLREAIADPKVWVFVVLQHLHLATNGFKNFFPTIVNTLGFNRTITLVLTCPPFLIAGAISILWAKSSGHFNESTWHITISKIVATFGFVLACSTMNVGARYFAMCVFTIGTYGVNSILLAWVGNTCGQTKEKKASALALANVSATLSLIWTPYLWPSSDAPRYVIPLSSSAAFAVACIAGVWLMRVMLVRQNRKIRQSDSEATLFYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6G1</accession>
    <name>C7Z6G1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinyl-CoA:3-ketoacid-coenzyme A transferase</fullName>
            <ecNumber evidence="3">2.8.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_76088</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:24564"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35973"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.8.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="3"/>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045838.1">
        <property type="nucleotide sequence ID" value="XM_003045792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6G1"/>
    <dbReference type="STRING" id="660122.C7Z6G1"/>
    <dbReference type="GeneID" id="9667961"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76088"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76088"/>
    <dbReference type="eggNOG" id="KOG3822">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019942_1_2_1"/>
    <dbReference type="InParanoid" id="C7Z6G1"/>
    <dbReference type="OMA" id="MQVNQFG"/>
    <dbReference type="OrthoDB" id="1933379at2759"/>
    <dbReference type="UniPathway" id="UPA00929">
        <property type="reaction ID" value="UER00894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:succinyl-CoA:3-oxo-acid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046952">
        <property type="term" value="P:ketone body catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014388">
        <property type="entry name" value="3-oxoacid_CoA-transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004164">
        <property type="entry name" value="CoA_transf_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF58">
        <property type="entry name" value="SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000858">
        <property type="entry name" value="SCOT-t"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01274">
        <property type="entry name" value="COA_TRANSF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="5-glutamyl coenzyme A thioester intermediate" evidence="4">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000858-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU40125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="525" mass="56998" checksum="56CF788D2DB350D9" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6M0</accession>
    <name>C7Z6M0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_76148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045869.1">
        <property type="nucleotide sequence ID" value="XM_003045823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6M0"/>
    <dbReference type="STRING" id="660122.C7Z6M0"/>
    <dbReference type="GeneID" id="9668064"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76148"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76148"/>
    <dbReference type="eggNOG" id="ENOG502SCNK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052827_4_1_1"/>
    <dbReference type="InParanoid" id="C7Z6M0"/>
    <dbReference type="OMA" id="EYPDCIT"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF6">
        <property type="entry name" value="THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="118"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU40156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="215" mass="23027" checksum="A60C995187D3045A" modified="2009-10-13" version="1">MTFPPIDSTIVCPALNLLFPGTPPDLFASELTFFASVPWTASLLSAPNTIPFLPSCRNPASSAHDQLFGLTLNNERGLSHLISFFHAPSTDAAKDPSHSITETVTLVSLGDGLSGFPGVTHGGMVASLLDESMGTIFDLNGTLRKEARAFQTPNVTGGLDIKFLKPVPTNGVYYITSTVDETDGRKTRIRCDLKDKDGEVLAKCSSKWVALKSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6P5</accession>
    <name>C7Z6P5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED4</name>
        <name evidence="10" type="ORF">NECHADRAFT_33637</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045881.1">
        <property type="nucleotide sequence ID" value="XM_003045835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6P5"/>
    <dbReference type="STRING" id="660122.C7Z6P5"/>
    <dbReference type="GeneID" id="9668077"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_33637"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_33637"/>
    <dbReference type="eggNOG" id="ENOG502SCD7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057381_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z6P5"/>
    <dbReference type="OMA" id="WPLEDKI"/>
    <dbReference type="OrthoDB" id="1929813at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019258">
        <property type="entry name" value="Mediator_Med4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10018">
        <property type="entry name" value="Med4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="120"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="232"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="140"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="238"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU40168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="340" mass="38122" checksum="2CFB08687E13FA35" modified="2009-10-13" version="1">MDTFIDRRFERLEKALANLIDSVTKYHPSTVHAQELEAADNELSKGLEEVQTHQNNYLRIQQLRESSAALDAQIRDTISSLATTRKDIVTTHATTFSAEPNYPIAYEELLNYARRISKTTMPPAGTINPVSPSPPEGQTPAGQTPGPDSQNASVMTPSAPPTSQVQSPAVMNGTPQVSQEPATQQTTTSANTNLPEGWTQFLNPLSGQLFFPWPQEDKIRAGSLASNQVLMEQGIEPKGYDPVEEEARKQREEEERKQKEEEARLAQEERERKIREDRERQRIERERQREKEQEAWRRASLVGGPSGAPGETKSTAGPPQQKAQFQFTNLDDLDDDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6T2</accession>
    <name>C7Z6T2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sister chromatid cohesion protein DCC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_76204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045896.1">
        <property type="nucleotide sequence ID" value="XM_003045850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6T2"/>
    <dbReference type="STRING" id="660122.C7Z6T2"/>
    <dbReference type="GeneID" id="9668099"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76204"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76204"/>
    <dbReference type="eggNOG" id="ENOG502SA0V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116847_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z6T2"/>
    <dbReference type="OMA" id="KGKWHEK"/>
    <dbReference type="OrthoDB" id="5199543at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019128">
        <property type="entry name" value="Dcc1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09724">
        <property type="entry name" value="Dcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU40183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14140" checksum="D54B5120F3BDF3B2" modified="2009-10-13" version="1">MSSQSRGITIQHTPSETNYRLIELPPELQSLLESDSAPVLTLESSDTSALLKTPSKTYALRQKNTSNAFMLLSPTPSTPENPEQGISIVSTIRETVELEVVPDKSAGTSGGATKSLGGAKGKWHERFGRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z735</accession>
    <name>C7Z735_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_76295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045947.1">
        <property type="nucleotide sequence ID" value="XM_003045901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z735"/>
    <dbReference type="GeneID" id="9668226"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76295"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76295"/>
    <dbReference type="eggNOG" id="ENOG502SQFV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087700_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z735"/>
    <dbReference type="OMA" id="PTQFEYP"/>
    <dbReference type="OrthoDB" id="5418203at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU40234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="168" mass="18378" checksum="9829A3D74B775D57" modified="2009-10-13" version="1">MSDDADVSASINKLSITSNKESTQTKKPAPKKKAKKVVADSWEDEDVSESEPEAESDKADELTPSATPAPPPPTPMSPVGGSTWTPPEDAPGPRAAGESAKRPEKTDAVARRMIAAGLGLKAPKQTEEQRAYQKSIREQEKKKREQEREQEKKRQEEADKAKAAIWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7V1</accession>
    <name>C7Z7V1_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_79567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045603.1">
        <property type="nucleotide sequence ID" value="XM_003045557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7V1"/>
    <dbReference type="GeneID" id="9672503"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79567"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79567"/>
    <dbReference type="HOGENOM" id="CLU_1343585_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z7V1"/>
    <dbReference type="OrthoDB" id="5076224at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU39890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="204" mass="22950" checksum="F42540D75ED29DE5" modified="2009-10-13" version="1">MTSIALDLLVDANNLNSCLASVISHLEERSNIGLSSINKSSSILDIKTPPVLFPRPIVDCEVYTNEPYVLDITSEYTRRPQEGLETIFTGFGSTIKNFVDRHRRRRNKVLSVTVQVTLRRVTIGAVINLPPPVPGKGKHTRVFRYTISAGGKDYPLKLWVKTSRGQLIDGEDGSSPEEPGVEDYYRASLHYARWMVESFYQFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z893</accession>
    <name>C7Z893_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="11">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_27580</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="11"/>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045670.1">
        <property type="nucleotide sequence ID" value="XM_003045624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z893"/>
    <dbReference type="GeneID" id="9672444"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_27580"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_27580"/>
    <dbReference type="eggNOG" id="ENOG502SING">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031730_4_0_1"/>
    <dbReference type="InParanoid" id="C7Z893"/>
    <dbReference type="OMA" id="HYTFDKL"/>
    <dbReference type="OrthoDB" id="3496539at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF2">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="13">
        <location>
            <begin position="16"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU39957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="264" mass="27660" checksum="DA36F7B0AA459B7E" modified="2009-10-13" version="1" fragment="single">SVASAVLASVASVYGHYTFDQLVVNDALEGSANTYIRKHQNSYMPTKFKNPPSGSITPLDADFSCNKGAVPAAQVFKVKAGDKVGLKMAYGGTGMEHPGPSQVYVSPVSDAASSDGSGDWYKIHQTLICKAGNAESLRTDAWCTWKEDQVWFNVPSSIPDGQYLVRGEHIGLHGAHNGEAEFYYACAQIEVAGNTATSIPGQSVKIPGVYKESDEAVNFSLWGSSTSYPVAPGPDVIPGGTIRGTADGATGDVTETVAGGESDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8N1</accession>
    <name>C7Z8N1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_43621</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045106.1">
        <property type="nucleotide sequence ID" value="XM_003045060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8N1"/>
    <dbReference type="GeneID" id="9673192"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_43621"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_43621"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_43_5_1"/>
    <dbReference type="InParanoid" id="C7Z8N1"/>
    <dbReference type="OMA" id="MSACLYW"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF26">
        <property type="entry name" value="MYO-INOSITOL TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="470"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="130"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU39393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="633" mass="71315" checksum="13A7ED3F117C2223" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCI4</accession>
    <name>C7ZCI4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_34678</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698918">
        <property type="protein sequence ID" value="EEU38374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044087.1">
        <property type="nucleotide sequence ID" value="XM_003044041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCI4"/>
    <dbReference type="GeneID" id="9670412"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_34678"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_34678"/>
    <dbReference type="eggNOG" id="ENOG502RVXR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_0_2_1"/>
    <dbReference type="InParanoid" id="C7ZCI4"/>
    <dbReference type="OMA" id="DITWWNV"/>
    <dbReference type="OrthoDB" id="10017208at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="35"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="250"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU38374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="311" mass="35220" checksum="CBF0F6738E1D4B60" modified="2009-10-13" version="1">MHYTHDPEIRAQNRGPVMIAVVVVLLCLSTTMVGLRILCRSMIKGFGLDDLAAVLTLVMTNYGLGRHDWTLTPVTLILYGRMTFLLHYYRLMSVSNMRNVYLGAIIIVALWGLSQSIMAFTQCIPLKAVWDPRVDGWCRAHQTTLWYINGIINIVSDFAILILPLPVIWKLQLPLSQKILLSGIFGLGLFTIAVSILRMQWLKPSPDMTWWNVTAASWSLAELTSAITCACLPTFKPLVVRIKPLFSTGNKGDSTVQLQRSSERDTESNMTTTGSQDRFTRDHKRPSRVYMYGTETRITATQDSRWSRQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZD70</accession>
    <name>C7ZD70_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">NECHADRAFT_63271</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698919">
        <property type="protein sequence ID" value="EEU38171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043884.1">
        <property type="nucleotide sequence ID" value="XM_003043838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZD70"/>
    <dbReference type="STRING" id="660122.C7ZD70"/>
    <dbReference type="GeneID" id="9670040"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_63271"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_63271"/>
    <dbReference type="eggNOG" id="KOG0743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010189_4_4_1"/>
    <dbReference type="InParanoid" id="C7ZD70"/>
    <dbReference type="OMA" id="LFMTTNK"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="16">
        <location>
            <begin position="33"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="262"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="485"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="414"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEU38171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="57609" checksum="6FE007D37F3F5834" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDP5</accession>
    <name>C7ZDP5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_54624</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043458.1">
        <property type="nucleotide sequence ID" value="XM_003043412.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9669601"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_54624"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_54624"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="InParanoid" id="C7ZDP5"/>
    <dbReference type="OMA" id="QYQIMWG"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001465">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="536"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="570"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="677"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1099"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1128"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1170"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1202"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1235"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1358"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="64"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="760"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="719"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="727"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU37745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1394" mass="154258" checksum="AA8B3AC767818A93" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZE42</accession>
    <name>C7ZE42_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_53596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698921">
        <property type="protein sequence ID" value="EEU37538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043251.1">
        <property type="nucleotide sequence ID" value="XM_003043205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZE42"/>
    <dbReference type="ESTHER" id="nech7-c7ze42">
        <property type="family name" value="Fungal-Bact_LIP"/>
    </dbReference>
    <dbReference type="GeneID" id="9669166"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_53596"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_53596"/>
    <dbReference type="eggNOG" id="ENOG502QRF9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029538_5_2_1"/>
    <dbReference type="InParanoid" id="C7ZE42"/>
    <dbReference type="OMA" id="IPMFVYK"/>
    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF5">
        <property type="entry name" value="LIP-DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013436045" evidence="2">
        <location>
            <begin position="19"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR029171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU37538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="429" mass="47218" checksum="977E5693FA593392" modified="2009-10-13" version="1">MHPLRWLLNLCAVPEVCSDAIIEGTTSSQEPLPPSRDPWYTVPSGFESKQPGDVLRIRSAPGNLTAVIGNPSAAYHILYRTTDSRDQPSWAVTTLFIPPSFYFSPSGKAALLSYQFAYNSANLDSSPSIGLYWRMAQREPNLGIKSNADFINYMLSLGWIVNTPDFEGPKASFGASKQAGHATLDGLRAVLGLINPHGHTEPNTAIWGYSGGSYATLAAAELQTQYAPEVKIDGTVLGGQTDNISADFDNLNKSPIAGTLIAFLLGVTSQYPEATAYLQSRLVPDTKEEFLSVRHINVVDAVRQFSGKDIYAYFKGGATDLQDPVLRKIYDEDVKLGYRGAPKMPMFVYKAIEDQFCPVDQTDTTVDRFCHGGADIRYERNTVGEHVSEIENGKPRAFKWLWSVFDESYEPSTAGCRIRNVTVKVDSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEX8</accession>
    <name>C7ZEX8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_97122</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043185.1">
        <property type="nucleotide sequence ID" value="XM_003043139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEX8"/>
    <dbReference type="STRING" id="660122.C7ZEX8"/>
    <dbReference type="GeneID" id="9665203"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_97122"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_97122"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_5_1"/>
    <dbReference type="InParanoid" id="C7ZEX8"/>
    <dbReference type="OMA" id="GWCSWQG"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000156">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="3"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="297"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU37472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="418" mass="46141" checksum="7FB604B787EB09E7" modified="2009-10-13" version="1">MSQAIIIGGGPAGLATALRLHQKTNILCTVYEIRPEPTTLGGAIGIPPNGLRLMDRLGVSDELHKHGSSHSTLSMHSIGGSLLGQQDLIGPARDITGFGYLRIKRMDLQKVLTEAVEKAEIPIHYDKRITSIKDTTDGVEVTFSDGTVDAGDLLLGCDGIHSAVRKLYVDPEQAPEYTGMAALGALVPASNFSETARSQIRGMNITFTEEGMMLAMVCTATDDEFFWGFSKEVPLPDSGDARDGWEVRRKEEVDGFKSSLLDTLKNAGGEWGNFMRQLVDNTSVVKFYPTYKLPLDRPWNKGRCLLLGDAAHAMPPHAGQGVSMALEDVFLLGRLLDNQPQSLPDTLQKFTEIRRPRVNEMASRSVQNGTIRRKTGPWGLWMKEMGLWMYMHGLWAFGMNRWGSATEQMVYDIDEVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZF07</accession>
    <name>C7ZF07_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_86417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043126.1">
        <property type="nucleotide sequence ID" value="XM_003043080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZF07"/>
    <dbReference type="GeneID" id="9665353"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86417"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86417"/>
    <dbReference type="eggNOG" id="ENOG502S0G3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023303_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZF07"/>
    <dbReference type="OMA" id="PRGLFCM"/>
    <dbReference type="OrthoDB" id="3433125at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053221">
        <property type="entry name" value="Burnettramic_acid_biosynth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38887">
        <property type="entry name" value="CHROMOSOME 21, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38887:SF1">
        <property type="entry name" value="RAS MODIFICATION PROTEIN ERF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="579" mass="64997" checksum="51CE8DC6115F7EDF" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFG9</accession>
    <name>C7ZFG9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">pectin lyase</fullName>
            <ecNumber evidence="8">4.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_78318</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Pectinolytic enzymes consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan methyl ester to give oligosaccharides with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.10" evidence="8"/>
    <dbReference type="EMBL" id="GG698923">
        <property type="protein sequence ID" value="EEU37148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042861.1">
        <property type="nucleotide sequence ID" value="XM_003042815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFG9"/>
    <dbReference type="SMR" id="C7ZFG9"/>
    <dbReference type="GeneID" id="9665002"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78318"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78318"/>
    <dbReference type="eggNOG" id="ENOG502QXM6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021980_0_1_1"/>
    <dbReference type="InParanoid" id="C7ZFG9"/>
    <dbReference type="OMA" id="DWCGSYP"/>
    <dbReference type="OrthoDB" id="1637350at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047490">
        <property type="term" value="F:pectin lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF67">
        <property type="entry name" value="PECTIN LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002987056" description="pectin lyase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate lyase" evidence="11">
        <location>
            <begin position="92"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU37148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="385" mass="41303" checksum="A2832760C918CB7E" modified="2009-10-13" version="1">MHFAPFLVLLGGVSSSLCQVVGSSYGFAKGVTGGGNATPQKPKDIAQYILQWLSDNTPRVIMIDKTFNFLGSEGNVTETGCRLTSGCTAANGGQSTVKMSGYGSNEKPVQVKYGKASYIGMPVGSNKSLVGVGNKGVLLGKGLRFNTGAKNIIIQNIHIDVVCLGGDAISLSSNDGVWIGHCKISRTGRHMFVSHYEASHVTISNTEFDGRTDFSNSCNNDHYWTIIIGGKGDKITLDKNYLHDRSGRAPKIGSSEGTQTVQAVNNYFNYNTGHNFDISSSGRVLVEDNRFENSKTPITDASKVGKIFNVPDSGSRTSCASLLGRNCEMNAYTSSGAVPSRKDTVVLSELGKYKSNLVTPIRYGEVKGYVNDNYDTCVGWLGPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFJ0</accession>
    <name>C7ZFJ0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_37097</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698923">
        <property type="protein sequence ID" value="EEU37161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042874.1">
        <property type="nucleotide sequence ID" value="XM_003042828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFJ0"/>
    <dbReference type="GeneID" id="9665153"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_37097"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_37097"/>
    <dbReference type="eggNOG" id="ENOG502SMC3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_3_4_1"/>
    <dbReference type="InParanoid" id="C7ZFJ0"/>
    <dbReference type="OMA" id="CKCSICI"/>
    <dbReference type="OrthoDB" id="3936451at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF96">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="27"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU37161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="362" mass="40603" checksum="4A979DD29769128C" modified="2009-10-13" version="1">MAIENRGPELTAVCATFITTAVIAVALRCYVRLRIVRNFGLDDGVMVGALVSFIILIAFTLLGVRYGTGRHYWDLEDNDIMLAMKFWWHCYLWYCITMITCKISIGLFLLRIAVRRVDIILIYTAMTVTALTCVAFFFITLFQCSPISFFWTRQQPGSCIDVDIIITITYIYSSFTVLCDFTFALLPIAMILKLNMNRRSKIALIPIMLMACVASAAVVVRFGYVKDFKNPDFLWATLDIAIWSTVEGGLGITAGSLATLRPLFRIIGPKFGLSTRGPSILQDSDQHQPRGFRGDSEGTRGRKKDEDLFSLTPVKGRSELGKVMETGNEGAQDIQMGKYHSSWVKQGKTQSNESEEELVVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZG57</accession>
    <name>C7ZG57_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dehydrogenase FUB6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Fusaric acid biosynthesis protein 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_86702</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="GG698924">
        <property type="protein sequence ID" value="EEU37022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042735.1">
        <property type="nucleotide sequence ID" value="XM_003042689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZG57"/>
    <dbReference type="GeneID" id="9664851"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86702"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86702"/>
    <dbReference type="eggNOG" id="KOG1196">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_29_1_1"/>
    <dbReference type="InParanoid" id="C7ZG57"/>
    <dbReference type="OMA" id="DVCQAKA"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="22"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00069006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00083301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU37022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="353" mass="38409" checksum="4FDEC0ECC66ACCFE" modified="2009-10-13" version="1">MAPTSNKSFIYKKIPDIYLVPGEHIVVEDRPLDLESAPLEGGILVKVFYTSLDPYIRDRTRDPSVEDFISALDVDTPIVSAIVGRVIRSESEKYQTGDLVMAFYGDHVEYALIKGDKLEDASLWKISNPHGLDITYFLGVLGMAGTTAFQGLYNIGKPKKGETIFVSAASGAVGQLVGQLAKAEGLKVIGSVGSQAKIDFVVNELGFDDAFNYKTEEYGEALKRLAPEGIDIFWDGIGGPQLDAALLAMKPHGRIVSCGTMVMYHTTPEDLYGVKNLWVLTNKYLKMEGFIVDLAIEKYEAMMEKVAPLIASGQFKVLQDITVGIENAPEALAGVFTGKNFGKAVLQIAEPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZG59</accession>
    <name>C7ZG59_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_86704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698924">
        <property type="protein sequence ID" value="EEU37108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042821.1">
        <property type="nucleotide sequence ID" value="XM_003042775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZG59"/>
    <dbReference type="STRING" id="660122.C7ZG59"/>
    <dbReference type="GeneID" id="9664937"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86704"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86704"/>
    <dbReference type="eggNOG" id="ENOG502RVY4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002639_3_0_1"/>
    <dbReference type="InParanoid" id="C7ZG59"/>
    <dbReference type="OMA" id="NDEASPH"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="194"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="664" mass="75842" checksum="381BA8BD7F850B10" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZG72</accession>
    <name>C7ZG72_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_86716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698924">
        <property type="protein sequence ID" value="EEU37030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042743.1">
        <property type="nucleotide sequence ID" value="XM_003042697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZG72"/>
    <dbReference type="GeneID" id="9664859"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86716"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86716"/>
    <dbReference type="eggNOG" id="ENOG502S2V9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004184_7_4_1"/>
    <dbReference type="InParanoid" id="C7ZG72"/>
    <dbReference type="OMA" id="FPSWALR"/>
    <dbReference type="OrthoDB" id="3553147at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="110"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU37030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="639" mass="71011" checksum="F75725E9A3FADB60" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZG88</accession>
    <name>C7ZG88_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_86731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698924">
        <property type="protein sequence ID" value="EEU37122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042835.1">
        <property type="nucleotide sequence ID" value="XM_003042789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZG88"/>
    <dbReference type="GeneID" id="9664867"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86731"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86731"/>
    <dbReference type="eggNOG" id="ENOG502T1HW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068285_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZG88"/>
    <dbReference type="OrthoDB" id="2520703at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="5"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="410" mass="46792" checksum="341B8C3C4997DA54" modified="2009-10-13" version="1">MVFFLPNEIWSQIFSHFKVVLYGLHRDLEPLKTLTALSLVSRRFHDLAQTPLYQTVLLWGINDYYSEDHHGPHFHLAKALANNPQLGLSTREISLTHGNLPSKHNLMSFLGDQIESPNISSEFIDLLKRDIIFGWRGSGVASFLLALMPRVRLVELYFYKEPSMSLPYILGGRLSYNSGEPHTVANHLHHLQELRITSAQAQTWLEVFTVSAGSRSLARQTPYIDWNVDLNEFGDVLRELGQNLVKLELVTRSYRHVLGLDVSGKVGSLQSLKSLKHLSISRNDFVGAEDDPTTIPLVEALPTSIEVMDFREDVTDSQMRQAEYGYEKMHDEIYGLAVGGQFPGLRKITLFRRGIPTKHRFQREVPGWDVEDMPPCVNGPLWEALKHPYYTYLTLYMQRRDDGSEGVQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZGB7</accession>
    <name>C7ZGB7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine amidotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_41980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698925">
        <property type="protein sequence ID" value="EEU36795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042508.1">
        <property type="nucleotide sequence ID" value="XM_003042462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZGB7"/>
    <dbReference type="STRING" id="660122.C7ZGB7"/>
    <dbReference type="GeneID" id="9670101"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_41980"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_41980"/>
    <dbReference type="eggNOG" id="KOG3179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054974_0_2_1"/>
    <dbReference type="InParanoid" id="C7ZGB7"/>
    <dbReference type="OMA" id="ATAELCH"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF6">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="69"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU36795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="269" mass="29851" checksum="C95AD5E9011F1340" modified="2009-10-13" version="1">MAVDSLVINVAVLNCGYTSPVIEKERGQYHDIFRVLLRDAVHRSSSLTKKPTLQLEGWDVVNQKYPLCLDRADAIIITGSPNGAYQPLEWIHVLQRYILRVYIERPHIKLYGSCFGHQIICKALFEDYGAIIQKDPAGYELGVHTINVSEEFASRFATLLPTKSLRLQFLHGDHVILPPGVLPEDACVIGSTPHCANQGIYQPGRLLTYQGHPEFDQFIEMECLKLVSARVGWPAKFTEAAIASAAAVDDAVIAAEIIVSFLLEPTVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZGZ1</accession>
    <name>C7ZGZ1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_64414</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698927">
        <property type="protein sequence ID" value="EEU36606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042319.1">
        <property type="nucleotide sequence ID" value="XM_003042273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZGZ1"/>
    <dbReference type="FunCoup" id="C7ZGZ1">
        <property type="interactions" value="458"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZGZ1"/>
    <dbReference type="GeneID" id="9669485"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_64414"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_64414"/>
    <dbReference type="eggNOG" id="KOG1382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020880_3_1_1"/>
    <dbReference type="InParanoid" id="C7ZGZ1"/>
    <dbReference type="OMA" id="FPWVNAS"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000065">
        <property type="entry name" value="Similar to histidine acid phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF14">
        <property type="entry name" value="ACID PHOSPHATASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="61"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="410"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU36606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="51596" checksum="3DF9E00F4CCB74E1" modified="2009-10-13" version="1">MPQQQAPLSHRLIQFLPLVAHTSASTLYSTYSFNPLEHLGGISPYFEPQDPPTSPDAPQGCKPERAAYLVRHAAIYANDFDYEEYIEPFVEKLENHTKIDWSKIPYLNFLADWSAPFSDAEAELLTRVGRLEATQLGVDLEFRYPKLRLPKRVWTSSAERTLKSAQSFVRGLEMDNQTIKVESIYESEESGADSLTPYSACPAYSSSAGSDEASVYQEKYAKPIIARLNDLAPDFNFTVNDVFGMQQLCGYETVIHGKSPFCNLELFSPDDWLGWEYSEDVRYHYNVGYGNQVSGYVGLPWFNATADILLNKESDDQDLYVSFTHRELPPMVLVAMGLFNNSQFGGPSQINDTMPLSRINYRRAWKSSHVLPFLSNIAIERLNCTGSYGYDDGEYYRVLVNSAPQPLPDCVDGPGTSCSRKGFEDYVQDRVDMFAGFSDKCGVDYKNTTDVLSIYHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHS5</accession>
    <name>C7ZHS5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pua rna binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_61639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698928">
        <property type="protein sequence ID" value="EEU36487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042200.1">
        <property type="nucleotide sequence ID" value="XM_003042154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHS5"/>
    <dbReference type="STRING" id="660122.C7ZHS5"/>
    <dbReference type="GeneID" id="9669231"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_61639"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_61639"/>
    <dbReference type="eggNOG" id="ENOG502SBMP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162852_1_1_1"/>
    <dbReference type="InParanoid" id="C7ZHS5"/>
    <dbReference type="OMA" id="AMTMDHR"/>
    <dbReference type="OrthoDB" id="10013825at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.10">
        <property type="entry name" value="Trypsin Inhibitor V, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021719">
        <property type="entry name" value="Prot_inh_I78"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39600">
        <property type="entry name" value="PEPTIDASE INHIBITOR I78 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39600:SF1">
        <property type="entry name" value="PEPTIDASE INHIBITOR I78 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11720">
        <property type="entry name" value="Inhibitor_I78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU36487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="9082" checksum="A6412F8FB0A5877A" modified="2009-10-13" version="1">MPLVVPGINSTSGDNADEWQNKLVGKKLSEEESNETVFCKRDLPEETRIIEPGMMVTKDFKENRLNVHLKDDGTVSHVVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZIG2</accession>
    <name>C7ZIG2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_97514</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698930">
        <property type="protein sequence ID" value="EEU36258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041971.1">
        <property type="nucleotide sequence ID" value="XM_003041925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZIG2"/>
    <dbReference type="FunCoup" id="C7ZIG2">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="GeneID" id="9674293"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_97514"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_97514"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="InParanoid" id="C7ZIG2"/>
    <dbReference type="OMA" id="GVMWLFI"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="18"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="505"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU36258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="527" mass="57247" checksum="0CA730A5C9A9B2AE" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJL2</accession>
    <name>C7ZJL2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_44403</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="GG698935">
        <property type="protein sequence ID" value="EEU35791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041504.1">
        <property type="nucleotide sequence ID" value="XM_003041458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJL2"/>
    <dbReference type="STRING" id="660122.C7ZJL2"/>
    <dbReference type="GeneID" id="9676307"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_44403"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_44403"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZJL2"/>
    <dbReference type="OMA" id="EFYAGAC"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019413">
        <property type="term" value="P:acetate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000001">
        <property type="entry name" value="Aldehyde dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000001">
        <property type="entry name" value="Mitochondrial aldehyde dehydrogenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="30"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU35791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="492" mass="53139" checksum="BE8F579D6C1A7324" modified="2009-10-13" version="1">MAPSLQITLPNGIEYSQPTGLLIDNEFMAASGDAFTVINPTREDIATFTGASGNDVNAAVAAARRAFEGPWSELPAAERGNLLMKLAGLIDRDRELLASIDAMDNGKTFSAALNIDIGASHNVFKYYAGAADKLSGSTVETHPSKFAYVLREPLGVCGQIIPWNFPFMMLAWKVAPALACGNTIVLKPAEQTPLSALYFGKLVVEAGFPPGVVNIVPGLGSVTGEALAEHMDVDKIAFTGSTITGRAIMRSAASNLKNITLECGGKNPSIVFDDADLDNAVKWCHMGIMDNQGQTCISTSRIYVQEEVYDRFIEKFTEVTRKKHFLGDPFDANTWQGPQISKTQYEKVLSYIEEGKKSGARLVYGGATHGQKGYFIEPTIFADTTEDMKIVQEEIFGPVVAISKFKTFDEVLAKANNSCYGLSAAVFTENITKGHKMARRLQAGMVFLNSSGDTHYGVPFGGYKSSGIGRELGQYALDAYTQTKAVHVNLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZK43</accession>
    <name>C7ZK43_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein acetyllysine N-acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.286</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SRT2103</name>
        <name evidence="10" type="ORF">NECHADRAFT_106479</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the sirtuin family. Class IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="2"/>
    <dbReference type="EMBL" id="GG698937">
        <property type="protein sequence ID" value="EEU35574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041287.1">
        <property type="nucleotide sequence ID" value="XM_003041241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZK43"/>
    <dbReference type="STRING" id="660122.C7ZK43"/>
    <dbReference type="GeneID" id="9676122"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_106479"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_106479"/>
    <dbReference type="eggNOG" id="KOG1905">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023643_6_1_1"/>
    <dbReference type="InParanoid" id="C7ZK43"/>
    <dbReference type="OMA" id="SNREYCK"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF12">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="9">
        <location>
            <begin position="17"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU35574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="396" mass="44239" checksum="029537EC86CF090B" modified="2009-10-13" version="1">MASTAPKVPLPERRDPPEVIDQQASKLVELIKRSKHFIVFTGAGVSTSAGELLHPVPHNNSSYSIQNTGIPDFRGPEGAWTLRAQGRARTTKAVSTLQAVPTPSHMALLELQNRGIMKYLVSQNCDGLHRRSGIRPDMISELHGNSNRECCRDCGKEYIRDFRAVATYEKTVRDHRTGRTCTRCGGLLHDSIINFGEDLPAEAFQLATDHAEKADLCLVLGSSLTVTPASGIPQICGMRRNAKLVICNLQNTPFDRISEMRVYSEADNLMTRVMQGLGLPIPTFILKRRLVIKAETDSNDRQSLTLSGVDVDGTPVSYLQSVKLEYNRRLLRSEPFTFSFRSALSPGTDLKFELEFMGHYNEPNLVVDYQVQDGEGHEAFYDLHYDPSTGEWMTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZK52</accession>
    <name>C7ZK52_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_86813</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698937">
        <property type="protein sequence ID" value="EEU35580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041293.1">
        <property type="nucleotide sequence ID" value="XM_003041247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZK52"/>
    <dbReference type="GeneID" id="9676128"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86813"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86813"/>
    <dbReference type="eggNOG" id="ENOG502RYZ7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007073_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZK52"/>
    <dbReference type="OMA" id="AWPAVED"/>
    <dbReference type="OrthoDB" id="8120565at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="39"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="240"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU35580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="759" mass="83806" checksum="23BB8BF395401926" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKP2</accession>
    <name>C7ZKP2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_51179</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698940">
        <property type="protein sequence ID" value="EEU35437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041150.1">
        <property type="nucleotide sequence ID" value="XM_003041104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKP2"/>
    <dbReference type="STRING" id="660122.C7ZKP2"/>
    <dbReference type="GeneID" id="9675722"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51179"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51179"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_1_1_1"/>
    <dbReference type="InParanoid" id="C7ZKP2"/>
    <dbReference type="OMA" id="AYCPSAM"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051704">
        <property type="entry name" value="FAD_aromatic-hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865:SF7">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="5"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU35437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="419" mass="47123" checksum="D5C97BA6B6464724" modified="2009-10-13" version="1">MAQPRVLICGAGIAGQALAFWLSKSHFNVTVIECFSGLRSTGLQLDLRGLGIEVMRRMGLEEAFRAKSVREQGLEIVDTYDKRWAYFPANKSGKGLQGFTTDFEIMRKDLCEILHESTKPRVKYAFGTTIESFTQHDNVVDVIFSDGNKDQFDLIVGADGQASRTRKAMLGADAEDPTHYLGAYIAYFTIPQPVEKGKDYNARFYLATGKRFIFTRRNEDFRVQIYMAYKTDTEWMKDIRKGDTGREKHAFLDMFKGAGWKTDTILKEMMATDDFYCERLGVVELDAWSDGRVALVGDAAFCPSASTGMGTTSSMVGAYVLAGELDKHCRESGKRGIPTALKAYDETFRPFMNQVQRGLTQGDSFWGRLPTSSFGVTVANVFMWLAMLLRLDVIGKRVLREDVGTWKLPDYETMVKGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKV7</accession>
    <name>C7ZKV7_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_42745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698941">
        <property type="protein sequence ID" value="EEU35397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041110.1">
        <property type="nucleotide sequence ID" value="XM_003041064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKV7"/>
    <dbReference type="GeneID" id="9675563"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_42745"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_42745"/>
    <dbReference type="eggNOG" id="ENOG502RJ61">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_733823_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZKV7"/>
    <dbReference type="OMA" id="QTHFAYL"/>
    <dbReference type="OrthoDB" id="5141931at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="377" mass="43717" checksum="D7C79DA3D78DFB40" modified="2009-10-13" version="1">MRKHTTPRRPKRQTALASRSPSGVLRNQHTRREFIRQQMSEGRPDPYRSWCGDPSCKKDGRVFMMPYSYPVNDEICKNGLPVEDYFHDLAKAMAIMLFPGLKSAEEKTRKFFEILSFIDSPIIRSQASRVMGGITWLSMKFTDRQFEVALIRARPVFLDLMFGVKTAERVEKIHSYVTAKASQYKGWTLHDFILRFLISAEVWRVHETPRKEGWVIGSREAVGEFLSAVLLGYHQLFARRCLVLTDVWLQRWDQIWQEWLEKYPVSKTLKEDDENDFKLRERQALTEEDVLEQVGYLGGIGKADGTYKPRRNRPKEPDQTFGDSLVVTDPTTNPPLTGLSMGERTGSRVLQWVWSYVPEVPLFRHIRAVGQGNRTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZL14</accession>
    <name>C7ZL14_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_78289</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698942">
        <property type="protein sequence ID" value="EEU35327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041040.1">
        <property type="nucleotide sequence ID" value="XM_003040994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZL14"/>
    <dbReference type="STRING" id="660122.C7ZL14"/>
    <dbReference type="GeneID" id="9675403"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78289"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78289"/>
    <dbReference type="eggNOG" id="ENOG502RI0K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011409_9_0_1"/>
    <dbReference type="InParanoid" id="C7ZL14"/>
    <dbReference type="OMA" id="FTKHSPY"/>
    <dbReference type="OrthoDB" id="3598904at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="94"/>
            <end position="150"/>
        </location>
    </feature>
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            <end position="460"/>
        </location>
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            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="120"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
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            <end position="414"/>
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    </feature>
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            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="441"/>
            <end position="454"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU35327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="761" mass="84193" checksum="08CEB54DB9E1EE26" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLM8</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_44838</name>
    </gene>
    <organism evidence="1 2">
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        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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            <taxon>Fusarium vanettenii</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_44838"/>
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    <dbReference type="OMA" id="EAFAYTE"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU35057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="517" mass="60477" checksum="45704C6D8414195E" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLW4</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">NECHADRAFT_78500</name>
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        <lineage>
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            <taxon>Hypocreales</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
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            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <end position="232"/>
        </location>
    </feature>
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        <location>
            <begin position="421"/>
            <end position="468"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
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        <location>
            <begin position="436"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="557" mass="61438" checksum="0C5B917CE34EA0B7" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMB7</accession>
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    </protein>
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        <name evidence="6" type="ORF">NECHADRAFT_55099</name>
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    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
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        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
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            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="9678971"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55099"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55099"/>
    <dbReference type="eggNOG" id="KOG1577">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZMB7"/>
    <dbReference type="OMA" id="RYNYPFR"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AKR"/>
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    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
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    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
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    </dbReference>
    <dbReference type="Pfam" id="PF00248">
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    </dbReference>
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        <location>
            <begin position="18"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU34824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="332" mass="36949" checksum="5C3110C4BD63BE6E" modified="2009-10-13" version="1">MSFGGTATLNSGYKIPNLGYGTWQATPGDVGRGVYEALRVGYRHLDLAKAYNNQREVGQGIRKALAEVPGLKRDDIFITSKLWNTKHRPEDVEPALDDTLAELGLDYLDLYLVHWPIAFRPGDDFMPKRAENDQEIDIYDGCSLTDTWNAFIKLPRTKVRSIGVSNFTIDHLEAIIKDTGIVPAVNQIERHPRVPDPLLIEYARKNNIHITAYSPLGNNYIGVPLLVSEPEVQAIAERLSKVQGKAITSAQVIIAWGQVGGHSVVPKSFTPSRIAENFQQVELDDEAISALHKFGQSPQRFSIPANFIPKWNINVFGSEAEKDAKHQVISRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMJ3</accession>
    <name>C7ZMJ3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_44704</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698953">
        <property type="protein sequence ID" value="EEU34760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040473.1">
        <property type="nucleotide sequence ID" value="XM_003040427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMJ3"/>
    <dbReference type="GeneID" id="9678894"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_44704"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_44704"/>
    <dbReference type="eggNOG" id="ENOG502S8A9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012800_3_1_1"/>
    <dbReference type="InParanoid" id="C7ZMJ3"/>
    <dbReference type="OMA" id="THRYYVQ"/>
    <dbReference type="OrthoDB" id="5344325at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF84">
        <property type="entry name" value="FUNGAL SPECIFIC TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="26"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU34760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="480" mass="53260" checksum="5A775ACEA8E09B63" modified="2009-10-13" version="1" fragment="single">SLELSGPILQASRAVPPRPYADMLVQSFFDNVNHHYCILYQPSFQASYEAWWSRRRDVSYLRAMTTIAFTSLILRVCSSATQFLPKDGQDRLESELGDSATDLSQLYHEAANSLSDLLPPGVAGLVNAQQLFLGATWLKAEANFVESWHMLADSVRQAQEIGIDTDKSPLDMTGYELDSRRRLWCSLDTWDSNPVPYPSTTLSLSGVCSDAPSAALAKVLENQLGRVLSGTEPGNRSLEESLATVESWMSALPPVFSLHASEKQWDEDAPWLRFQRLQLHCVGYMTQLALMKTALVVEPQHQNHIEKATEIGLLAMSVCEEFFDLCFPHHAKYFMVSFCPFDVAALLCSLLLRDTNKTLSKRAEMVNAVGSALSISFRLRDYTKMGEPTWTILNALVSRLQLESGETEALGNSARARNLGDGELESIHRGQVLPSEGVAAPVSQWQDENVLFGGSTEGSLDLGVLDGVWDWQSLSNEFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMM8</accession>
    <name>C7ZMM8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_87002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698957">
        <property type="protein sequence ID" value="EEU34718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040431.1">
        <property type="nucleotide sequence ID" value="XM_003040385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMM8"/>
    <dbReference type="GeneID" id="9678853"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87002"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87002"/>
    <dbReference type="HOGENOM" id="CLU_1166105_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZMM8"/>
    <dbReference type="OrthoDB" id="4733424at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU34718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="238" mass="26647" checksum="B1C63238C79C3E05" modified="2009-10-13" version="1">MSEYTHIDTRPMVWVSRKIMTIFSILIFFDIGMMVTTIMAVTGAETADPRDIVQGAKIDFPPPGEQIQALEIGLAAFGLFFHILFALIFLGRVKKAKQTMDYASGTRLTEFVLYIVLPFLVIEVAGWAVCLGFQSLYAPVIKPRKLLACHYLGPDLVHFVHFVLLMLVLRAYYRMDPVAEPSPQYAGVPSAEDAHHSLPQDHGAPPSYEERESGHLIGKSTKTQPQHVEMSRMTTLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNH7</accession>
    <name>C7ZNH7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_87045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698968">
        <property type="protein sequence ID" value="EEU34427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040140.1">
        <property type="nucleotide sequence ID" value="XM_003040094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNH7"/>
    <dbReference type="STRING" id="660122.C7ZNH7"/>
    <dbReference type="GeneID" id="9677971"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87045"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87045"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_257246_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZNH7"/>
    <dbReference type="OMA" id="DIATTIC"/>
    <dbReference type="OrthoDB" id="5098218at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="201"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU34427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1180" mass="130447" checksum="E7813BE279C68F3E" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNJ1</accession>
    <name>C7ZNJ1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phenylacetyl-CoA ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_94784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698969">
        <property type="protein sequence ID" value="EEU34416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040129.1">
        <property type="nucleotide sequence ID" value="XM_003040083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNJ1"/>
    <dbReference type="STRING" id="660122.C7ZNJ1"/>
    <dbReference type="GeneID" id="9677946"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94784"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94784"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="InParanoid" id="C7ZNJ1"/>
    <dbReference type="OMA" id="QCAYLCF"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="47"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="474"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU34416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="576" mass="63742" checksum="CBF2E4AAAF008149" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPB5</accession>
    <name>C7ZPB5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Beta-xylanase</fullName>
            <ecNumber evidence="10">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_25306</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040035.1">
        <property type="nucleotide sequence ID" value="XM_003039989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZPB5"/>
    <dbReference type="GeneID" id="9677674"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_25306"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_25306"/>
    <dbReference type="eggNOG" id="ENOG502QR4K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020161_12_1_1"/>
    <dbReference type="InParanoid" id="C7ZPB5"/>
    <dbReference type="OMA" id="GIADNHT"/>
    <dbReference type="OrthoDB" id="3055998at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF35">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002989340" description="Beta-xylanase" evidence="12">
        <location>
            <begin position="18"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="13">
        <location>
            <begin position="16"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="407"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU34322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="448" mass="47686" checksum="189B360DA414FD78" modified="2009-10-13" version="1" fragment="single">MYKTALLGLLASSPVSAQLNSLAQAAGLQYFGTTVDNGYLSDEAYKAIADDTEEFGQLVPENGQKWDSTEPTKGTFSYEKADVVPDLAKKNGQILRCHALTWHSQLPSWVSGGSFSKEELTSIIEAHISNVVGHYKGDCYAWDVVNEAIGDDGNWRDSVFYQTLGTDYLAISFNAARKADPDAKLYYNDYNLEGNGAKTERALELVKIVQDAGAPIDGVGFQGHLIVGQTPSRANLATVLKRFTALNIEVAYTELDIRHASIPASESALKTQGDDFANVVGSCLDAEGCVGVTIWGVSDKYSWVPNTFSGAGEALIYNDQYEKKPAWTSISSLLAAAATGSSGKASTATSVAPVVETSAPATTLETRTKPAVSISEAAPAPEPTSLIVTPFLNNTATQTTLEIRTSAAAPIASEDQDDEDCDDEEQPEPFPTYAVPGNSTTPINGTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPL5</accession>
    <name>C7ZPL5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="10">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_50108</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="10"/>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040085.1">
        <property type="nucleotide sequence ID" value="XM_003040039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZPL5"/>
    <dbReference type="FunCoup" id="C7ZPL5">
        <property type="interactions" value="360"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZPL5"/>
    <dbReference type="GeneID" id="9677753"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_50108"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_50108"/>
    <dbReference type="eggNOG" id="KOG0787">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023861_4_1_1"/>
    <dbReference type="InParanoid" id="C7ZPL5"/>
    <dbReference type="OMA" id="WSYPPSA"/>
    <dbReference type="OrthoDB" id="3264224at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF20">
        <property type="entry name" value="[3-METHYL-2-OXOBUTANOATE DEHYDROGENASE [LIPOAMIDE]] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="294"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="326"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU34372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="481" mass="52693" checksum="6CF732E9106BC9B8" modified="2009-10-13" version="1">MTRRVTQRLQSWTWSPAAAAAHGPWQRQHLSQWRAYRQLQRGSALARLPTRRCIHTQQVSDDEIATLARQHQHPLSLADLVRHGRPPLAADSLLSSANFALSLLPVRLAHRIQALRNLPYIVVANPNISRIYNNYVHSLSILLPYWHATREGRPISTTEDEVRFTNVLAELVATHTDTIPILAKGFLECRRYISPEEVTRFLEHHLRARIGTRLIAEQHIALHFSSQSHFNPSASPTPCPEHPSYIGVIDTALRPAQIVESCAGFVADICELRYGVRPLLYIDGEPDTTFAFVPMHLEYIVTELLKNAFRATVESKSKEPVIVTIAPEPGNHQNSPPSPSSLPAKEPAPVVLRPSEDDDRSAFRSGAIAPLDDNAPGVTIRIRDRGGGIPPDVAPSIWSYSFTTFTDDPDNVPGSGSGNDGLSAISAASTGGSSIAGLGYGLPLSRAYAEYFGGGIAVQSLYGWGTDVYLRLKGVGNLDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQ10</accession>
    <name>C7ZQ10_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_88815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698978">
        <property type="protein sequence ID" value="EEU33890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039603.1">
        <property type="nucleotide sequence ID" value="XM_003039557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQ10"/>
    <dbReference type="GeneID" id="9667123"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88815"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88815"/>
    <dbReference type="eggNOG" id="ENOG502T88R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010836_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZQ10"/>
    <dbReference type="OMA" id="GQDMFGH"/>
    <dbReference type="OrthoDB" id="10016792at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1013"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1070"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU33890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1216" mass="129483" checksum="DCBAFD4E2D7FEF58" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQX8</accession>
    <name>C7ZQX8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_89345</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699019">
        <property type="protein sequence ID" value="EEU33577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039290.1">
        <property type="nucleotide sequence ID" value="XM_003039244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQX8"/>
    <dbReference type="STRING" id="660122.C7ZQX8"/>
    <dbReference type="GeneID" id="9666813"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89345"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89345"/>
    <dbReference type="HOGENOM" id="CLU_794744_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZQX8"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU33577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="349" mass="38352" checksum="4733F20B16A164E8" modified="2009-10-13" version="1">MTPFPRAGLNRPSSWDTWGSLRRFGHCSEDDVDPDQHWLTWVECSPAMPFLAYTKVKGPWAAPRGNNEVRGQPSSNPPRDTRMTSSCFSYPCPVQSLGRTGRAKRIPWVYVTHNGHTSLNIASLSEDIATIRNLLEAGADVDCTAKGHGCSSLHHATTAKIMAVLLQYNPDVNIAYGDGKTTLYSLTSTTLLDMVAAKALVNIGTKVNLQDNKGRTPLLDMVPIVSDSSSRSYSLVVEYLLSKKADLNIPTLLDVSPLRCGSVASRLGWTALCWAARETAANRKMEVIKLLLGQGGKRSLKVQAYEEDEQWTLKAITTFHGLPATVMELLEGELEPEATRGMERYSSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7YH85</accession>
    <name>C7YH85_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leo1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PAFB2101</name>
        <name evidence="2" type="ORF">NECHADRAFT_74883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054302.1">
        <property type="nucleotide sequence ID" value="XM_003054256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YH85"/>
    <dbReference type="FunCoup" id="C7YH85">
        <property type="interactions" value="141"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YH85"/>
    <dbReference type="GeneID" id="9664458"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74883"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74883"/>
    <dbReference type="eggNOG" id="ENOG502S4N0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030892_1_0_1"/>
    <dbReference type="InParanoid" id="C7YH85"/>
    <dbReference type="OMA" id="TNIYRWS"/>
    <dbReference type="OrthoDB" id="20844at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007149">
        <property type="entry name" value="Leo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146">
        <property type="entry name" value="LEO1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146:SF0">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN LEO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04004">
        <property type="entry name" value="Leo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU48589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="45943" checksum="13A5DDC799CA7E5C" modified="2009-10-13" version="1">MSDSEDPIDPIDEGGDDLFGDEGDEDVASTKERVLDDDDLASDPEGDSYARYRNDYDDQMQFQTRDRVVMGVKTYRHRIPKPKDGALRVMRIPKFVKIMPEEYDPDTFQPTEFDLANAKAQHPKHVARVRRDHSTGELKSNTNIFRWSDGSVTISIGGEHYEVQKKALAPSADKPYNEIHDGHYYAAAAELHSNLLMTVGHITEQYNVRPNKAVGDDALSILAERMAQASKPSQGGDMIIRTTRDPELQKKQAELAEKERMKAQRRRENAAAKMDGGYGRSGRGNLSIGELEGGRRFGSSRKRGAPGSSRPKPRRGESESDEELAEAVGRHEGYDLDDGFIVGSDVEEMDSQADDDDEEELLDEDEDEKPRSKRQRTRDRSPDEDAEGSDVEQVAGRARRRNVIDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHC0</accession>
    <name>C7YHC0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAR-17a/AIG1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_102377</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054319.1">
        <property type="nucleotide sequence ID" value="XM_003054273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YHC0"/>
    <dbReference type="FunCoup" id="C7YHC0">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="GeneID" id="9664475"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102377"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102377"/>
    <dbReference type="eggNOG" id="KOG3989">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081915_0_0_1"/>
    <dbReference type="InParanoid" id="C7YHC0"/>
    <dbReference type="OMA" id="TIAFGYW"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006838">
        <property type="entry name" value="ADTRP_AIG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989">
        <property type="entry name" value="ANDROGEN-INDUCED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989:SF16">
        <property type="entry name" value="AT02829P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04750">
        <property type="entry name" value="Far-17a_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU48606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="26182" checksum="36DB2F0BBA02FC17" modified="2009-10-13" version="1">MAAHPLQRLTSPSRSVSLLLHVLGLASFSYNFHFLTVWETPLSVSYGWHFQFLTIIGLTASLIAFALGVLADLTLSHALFQAKNAVAVLATPLEVVISILYWGIRFIDPNLLMAGDFVLDMLPDIGFHLAPAVFLTLDLILLSPPWTIPAYTIMAISTVIAFAYWYWVELCFSHNGWYPYPLFELLSTEQRVLLFTFSAGLVTVSSSCLKWVYARVNGYQAAQKEAHKPLKKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHG1</accession>
    <name>C7YHG1_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_74960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
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                <person name="Rodriguez-Carres M."/>
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                <person name="Geiser D.M."/>
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        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
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                <person name="Coutinho P.M."/>
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                <person name="Selker E.U."/>
                <person name="Salamov A."/>
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                <person name="Lindquist E."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054534.1">
        <property type="nucleotide sequence ID" value="XM_003054488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIK0"/>
    <dbReference type="FunCoup" id="C7YIK0">
        <property type="interactions" value="660"/>
    </dbReference>
    <dbReference type="GeneID" id="9664652"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_103236"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_103236"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006909_5_0_1"/>
    <dbReference type="InParanoid" id="C7YIK0"/>
    <dbReference type="OMA" id="MVTPLWK"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000138">
        <property type="entry name" value="Flavin-containing monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU48821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="54798" checksum="868DB3196AFCDCFC" modified="2009-10-13" version="1">MPLAEKLQVRRIAIIGAGPSGLAAAKYLLAEKKFSKVHIFEQRATPGGVWNYTPLARENGFSVPRTKPSSLPDQALWPKDGGEVEFMSPIYDLLETNIPHSLMNYTDKEFPQGSSLFPRHSAVLQYLKEYAEDITPHISYQSQVLSIEKPGTDKSKPWQVEVLDLKANKATKDEFDAVVVASGHYNDPFIPDIPGLVEFDKAYPGAISHSKFYRRPNDYKDKKVIVVGNSASGVDVSAQLSAVAKHPIFISEKEKPTVTPPTKESWAANVPQIVEFLPSKRGVRFANDQVETDIDAVIFCTGFHYSYPFLKSLEPSIVVPDGGYAAHLWEQILYTADPTLAFLSVPQRVVPFPIAEAQSAVAARIWSGRLSAPTTAEMEAWIESEHEKKGSGKAIHLMHSPEDVDYINRLYELSKTAPKAPELGLENDGEGKRPPYWGLDKRWVRERVPKIKLASRAVGEKRHEIKKLEDLGFDYEEWKRTLEEGEKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIS2</accession>
    <name>C7YIS2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor Cactin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_75424</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CACTIN family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053857.1">
        <property type="nucleotide sequence ID" value="XM_003053811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIS2"/>
    <dbReference type="STRING" id="660122.C7YIS2"/>
    <dbReference type="GeneID" id="9676490"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75424"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75424"/>
    <dbReference type="eggNOG" id="KOG2370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011759_3_0_1"/>
    <dbReference type="InParanoid" id="C7YIS2"/>
    <dbReference type="OMA" id="RNRRYWE"/>
    <dbReference type="OrthoDB" id="265955at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019134">
        <property type="entry name" value="Cactin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018816">
        <property type="entry name" value="Cactin_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737">
        <property type="entry name" value="POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737:SF4">
        <property type="entry name" value="SPLICING FACTOR CACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10312">
        <property type="entry name" value="Cactin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09732">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Splicing factor cactin central" evidence="5">
        <location>
            <begin position="48"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Splicing factor Cactin C-terminal" evidence="4">
        <location>
            <begin position="345"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="242"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU48144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="482" mass="55659" checksum="FC208E2A4C7AF7F3" modified="2009-10-13" version="1">MDPGRRAMISGRKSPTRRDVTSPRHDPSNRITKSTKPAVSKINPRYLTQDEQSRQFVADEDKFVLKQSKKKADIRVREGRAKPIDYLAFNLRYIDSDRDVFDDDDTDIDIDVPAPADVITSLDAEQIAELDSDIASYHVLETNATNREYWKSLQTLCADRKAKLNPHGHDQRVVSSVSDDIDKILAPKTHDQLEALEKQIKAKLQSNEDIDTDYWEQLLRSLRVWKARAKLDQVYETIKKNRHDQLKDRDPAKANVVGQTSATNVSQRPAASISKDETSKPTAVSSSSHADRSVPPGTERFSQADNEDFSQATKALYDREVARGVDENEEIFTSEEAVTTTKPQWADKYRPRKPRYFNRVQMGYDWNKYNQTHYDHDNPPPKVVQGYKFNIFYPELIDKTKAPTFKIIREHGRRRGESFAAAGEEDTCLIRFIAGPPYEDIAFRIVDREWDYSAKRDRGFKSSFDKGILQLHFQFKKIYYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJH8</accession>
    <name>C7YJH8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_75683</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053992.1">
        <property type="nucleotide sequence ID" value="XM_003053946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJH8"/>
    <dbReference type="GeneID" id="9676611"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75683"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75683"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_11_0_1"/>
    <dbReference type="InParanoid" id="C7YJH8"/>
    <dbReference type="OMA" id="ACENCIG"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF15">
        <property type="entry name" value="ALPHA-GLUCOSIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="3"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU48279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="467" mass="50993" checksum="4CFE6660365AAB18" modified="2009-10-13" version="1">MSISLACSSAAVLIGYDMTLIGSIIANVEFVKKFGDYDAKTDTWSLPADEQLVWSVVQYVSAMCGAMGAGYMNDVIGRRAVFCILVACTMVGTIIELFSPDWKVWIVAKLLFGAAMGFMQGTIPAYISELAPSRVRGFLLSLFQFWIMFGAFVAACVLEGTSHVEGPWSWKGTIVSQLGLGVMCLALFIPLVPESPYYLVSKGRLDAAKAALLKMRGSEANYMVEEDLAAIVGLLEHEKLEKGASPSYMECFQGPNLRRTFLACLPMVMQHFLGYPLCGNYLAYFLTLSGMDNSFTITVISMTVAMLAIICAFVLIERVGRRLQYLVGTFAILPLLLCIGILGFVPSSTAVLRGVASLCIIWSFLWYLSVGAVGWTIVGEISSPRLRPKTTSLAATINSLINMGWSIAIPYLVNSERANLGPKTGLVFFAPSLFLAAIAYFVMPETKGKTFEELDALFESRTPARKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7YK17</accession>
    <name>C7YK17_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7892 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_31285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054083.1">
        <property type="nucleotide sequence ID" value="XM_003054037.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9676709"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_31285"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_31285"/>
    <dbReference type="eggNOG" id="ENOG502RPXF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003437_0_0_1"/>
    <dbReference type="InParanoid" id="C7YK17"/>
    <dbReference type="OMA" id="WRTEMIK"/>
    <dbReference type="OrthoDB" id="2322499at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057214">
        <property type="entry name" value="DUF7892"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25422">
        <property type="entry name" value="DUF7892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7892" evidence="2">
        <location>
            <begin position="836"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1360"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1116"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1148"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1162"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1420"/>
            <end position="1431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU48370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1431" mass="158625" checksum="F2558734933DBCD0" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7YL23</accession>
    <name>C7YL23_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell wall galactomannoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_123303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052429.1">
        <property type="nucleotide sequence ID" value="XM_003052383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YL23"/>
    <dbReference type="GeneID" id="9671425"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_123303"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_123303"/>
    <dbReference type="eggNOG" id="ENOG502SFS3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092498_2_0_1"/>
    <dbReference type="InParanoid" id="C7YL23"/>
    <dbReference type="OMA" id="QKDICET"/>
    <dbReference type="OrthoDB" id="5089392at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17615">
        <property type="entry name" value="C166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988109" description="Cell wall galactomannoprotein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU46716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="18903" checksum="FA6C2CABBE01827B" modified="2009-10-13" version="1">MQFKLLTAVTTFLAASSVQAAIAPSDIVKTLETVTDLSSDTNDIAKTITNPVQIFTAVPKLIGSFKDIIGTVTNAISMLGDLPDDPKFPESGQSEICEAFTGFVKVHQNLLETIIGKEGLLSNTPFTAPIAAVLRVLENIVDKVAFTIIGTVPTCADGAKKDLQDLDETLGKTIDTYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLB6</accession>
    <name>C7YLB6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">N-alkane-inducible cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_36424</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052472.1">
        <property type="nucleotide sequence ID" value="XM_003052426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YLB6"/>
    <dbReference type="STRING" id="660122.C7YLB6"/>
    <dbReference type="GeneID" id="9663635"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_36424"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_36424"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_27_0_1"/>
    <dbReference type="InParanoid" id="C7YLB6"/>
    <dbReference type="OMA" id="WCVQESL"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF17">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0349">Heme</keyword>
    <keyword evidence="8 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU46759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="57691" checksum="3AF89A113EAB936B" modified="2009-10-13" version="1">MLSPLLTKFLEQHLVLTIVLLLVPFPLRALETYLRRWRLAQARGCREARSKVAVKDPIIGFDFLYRALFSHAPERYLDSTWAAFKEMGTTYVEKRWTWQCVYTCDPLNLKQILATASEDFDLPEFRTSVIGHVFGRGIFVLSGHTWKHARTVLRRSFKKENPAPFLETLERNFQAFTSHVPTDGSEVDLQPLFLGLTMDVATEFLMGHSTGMLRNKGDHSREQQFVDDYMVCSEEIIQQMQLGPLHQLKFNFKAKKAKKRVYEYLDKFIDESLQHSKESNPGSNFLADMMAIAKDRKGLSDQILHILLASRDTTSSLLSNLFFVLSKNPDIFAKLRQEVLHISGQEPPTAHQLKEMTYMKWCVNESLRLHPVIPTNARVAVRDTTIPRGGGADGQSPLLVPRGTAMFYNVYAMHRSEAVFGPCAEEFIPERWRDLRPGWGYLPFNGGARACIGQQYALLETHYVVARMAQTYTRLESRDDRDWMELYALALCSKNGTRVAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLX5</accession>
    <name>C7YLX5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8035 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_91820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053064.1">
        <property type="nucleotide sequence ID" value="XM_003053018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YLX5"/>
    <dbReference type="STRING" id="660122.C7YLX5"/>
    <dbReference type="GeneID" id="9663905"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_91820"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_91820"/>
    <dbReference type="eggNOG" id="ENOG502SM5I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005727_0_0_1"/>
    <dbReference type="InParanoid" id="C7YLX5"/>
    <dbReference type="OMA" id="NYNADQR"/>
    <dbReference type="OrthoDB" id="5418088at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058348">
        <property type="entry name" value="DUF8035"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42081:SF2">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42081">
        <property type="entry name" value="ZINC FINGER PROTEIN DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26118">
        <property type="entry name" value="DUF8035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8035" evidence="2">
        <location>
            <begin position="728"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="768"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="829"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU47351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="860" mass="99573" checksum="C2C368EDA65B9401" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7YM34</accession>
    <name>C7YM34_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_99624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052587.1">
        <property type="nucleotide sequence ID" value="XM_003052541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YM34"/>
    <dbReference type="STRING" id="660122.C7YM34"/>
    <dbReference type="GeneID" id="9663938"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_99624"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_99624"/>
    <dbReference type="eggNOG" id="ENOG502SZQW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109868_2_0_1"/>
    <dbReference type="InParanoid" id="C7YM34"/>
    <dbReference type="OMA" id="EHADIAF"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42090:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU46874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="139" mass="15116" checksum="0D13D92A64D39C46" modified="2009-10-13" version="1">MPLFRNVLRATQTTVRPLHTTSRLRVPYKDSQDRESLRPVSNENTKSGRDEQMTSEHADTAFDPNTTRPEEEAAQTRQSTSKKGPEGEDPLHASGANQDISKPLGDENTIKKTGAGKETSKGGASRKGSASKKGQPKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7YM58</accession>
    <name>C7YM58_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase family 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_35408</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053110.1">
        <property type="nucleotide sequence ID" value="XM_003053064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YM58"/>
    <dbReference type="STRING" id="660122.C7YM58"/>
    <dbReference type="GeneID" id="9671130"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_35408"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_35408"/>
    <dbReference type="eggNOG" id="ENOG502QTNX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008392_3_0_1"/>
    <dbReference type="InParanoid" id="C7YM58"/>
    <dbReference type="OMA" id="NVSHACL"/>
    <dbReference type="OrthoDB" id="4215304at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000008">
        <property type="entry name" value="Beta-N-acetylglucosaminidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000013">
        <property type="entry name" value="Glycoside hydrolase family 3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050226">
        <property type="entry name" value="NagZ_Beta-hexosaminidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480">
        <property type="entry name" value="BETA-HEXOSAMINIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480:SF8">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 3 N-terminal" evidence="5">
        <location>
            <begin position="18"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU47397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="946" mass="102980" checksum="AF50F04F647ED2BF" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>C7YMG7</accession>
    <name>C7YMG7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Transaldolase</fullName>
            <ecNumber evidence="4 10">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_59218</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transaldolase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="4 10"/>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052659.1">
        <property type="nucleotide sequence ID" value="XM_003052613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YMG7"/>
    <dbReference type="FunCoup" id="C7YMG7">
        <property type="interactions" value="820"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YMG7"/>
    <dbReference type="GeneID" id="9671191"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_59218"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_59218"/>
    <dbReference type="eggNOG" id="KOG2772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047470_0_1_1"/>
    <dbReference type="InParanoid" id="C7YMG7"/>
    <dbReference type="OMA" id="THAEFLW"/>
    <dbReference type="OrthoDB" id="2015515at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00957">
        <property type="entry name" value="Transaldolase_TalAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000088">
        <property type="entry name" value="Transaldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004730">
        <property type="entry name" value="Transaldolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00874">
        <property type="entry name" value="talAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU46946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="323" mass="35468" checksum="039F4D5E63542B1A" modified="2009-10-13" version="1">MSTSLDQLKASGTTVVSDSGDFASIGKYKPQDATTNPSLILAASKKAEYAKLIDVAIDYAKQKGGSADQQVDDALDRLLVEFGKEILKIIPGKVSTEVDARYSFDTQASVNKALHLIELYGEQGISKDRVLIKIAATWEGIKAAEILQRDHGINCNLTLMFSLVQAIGAAEAGAYLISPFVGRILDWFKAHTKKDYAKEEDPGVASVKAIFNYYKKFGYNTIVMGASFRNTGEITELAGCDYLTISPNLLEDLLNSEEAVPKKLNAEEATALDIEKKTYINDEPLFRFDFNEDQMAVEKLREGISKFAADAVTLKDILKEKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7YMY7</accession>
    <name>C7YMY7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_36281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052744.1">
        <property type="nucleotide sequence ID" value="XM_003052698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YMY7"/>
    <dbReference type="GeneID" id="9664234"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_36281"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_36281"/>
    <dbReference type="eggNOG" id="ENOG502S73V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080664_2_1_1"/>
    <dbReference type="InParanoid" id="C7YMY7"/>
    <dbReference type="OMA" id="GIQNGMT"/>
    <dbReference type="OrthoDB" id="1601230at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044662">
        <property type="entry name" value="HS1/DABB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178:SF10">
        <property type="entry name" value="STRESS-RESPONSE A_B BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="2">
        <location>
            <begin position="3"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU47031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="110" mass="12110" checksum="F32071FF0B337A2B" modified="2009-10-13" version="1">MSVTHTVLFQFKADAKPDDIKAACGRFLALKDNCIHPTTNTVYINSLKGGQDNSPEGLQNGITHGFVVEFSSVEDRDYYVKTDPAHQAFIKSLDGLVEKAIVVDFNDGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7YN56</accession>
    <name>C7YN56_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_36398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053277.1">
        <property type="nucleotide sequence ID" value="XM_003053231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YN56"/>
    <dbReference type="STRING" id="660122.C7YN56"/>
    <dbReference type="GeneID" id="9664343"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_36398"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_36398"/>
    <dbReference type="eggNOG" id="ENOG502R9UI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021768_3_3_1"/>
    <dbReference type="InParanoid" id="C7YN56"/>
    <dbReference type="OMA" id="RFWQHEV"/>
    <dbReference type="OrthoDB" id="8300194at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF55">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU47564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="213" mass="24559" checksum="CA8058B6B9752A0A" modified="2009-10-13" version="1">MQFVASQTSIPVPKVYYAFTHKGTSYIVMRHIKGQMAGYNWAHRPEESRRILEQLRSMVAELRSVTPPEGAQVGSIDGGPFWDCRLPSRDYWGPYSTVREFHQALANGIPWDCDCTKFPDLAELLTFYQQAENKLVLTHGDLSSLNILTHGDAVVGIVDWETAGWFPPYWKYTTAKYVNPQNPFWADPVDQFITPMPEELRMETIRRKYFGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNB7</accession>
    <name>C7YNB7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">IMP-specific 5'-nucleotidase 1</fullName>
            <ecNumber evidence="12">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_35271</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">IMP-specific 5'-nucleotidase involved in IMP (inositol monophosphate) degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>IMP + H2O = inosine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27718"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="3.1.3.99"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ISN1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="12"/>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053307.1">
        <property type="nucleotide sequence ID" value="XM_003053261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNB7"/>
    <dbReference type="FunCoup" id="C7YNB7">
        <property type="interactions" value="92"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YNB7"/>
    <dbReference type="GeneID" id="9664373"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_35271"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_35271"/>
    <dbReference type="eggNOG" id="ENOG502QR24">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031816_1_0_1"/>
    <dbReference type="InParanoid" id="C7YNB7"/>
    <dbReference type="OMA" id="WGVLACQ"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006190">
        <property type="term" value="P:inosine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071590">
        <property type="term" value="P:nicotinamide riboside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071592">
        <property type="term" value="P:nicotinic acid riboside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009453">
        <property type="entry name" value="ISN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28213">
        <property type="entry name" value="IMP-SPECIFIC 5'-NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28213:SF1">
        <property type="entry name" value="IMP-SPECIFIC 5'-NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06437">
        <property type="entry name" value="ISN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028836">
        <property type="entry name" value="ISN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU47594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="431" mass="47712" checksum="7407C7B34164643B" modified="2009-10-13" version="1">MTTRYRVECLLAVPFVLYSQPTGVFGDGPSVAQMADESHRRYAEIMRDVELMIDDHIARQQGNNLLPSKLRMLVPTAGPFFTRLPLEAAFKYQDRKRYISSRRFVAPSFNDVRQILNSAQVMAVTNGALQLATFDGDVTLYDDGCSLEPSSPVIPRLLDLLRKNIKIGIVTAAGYTSADRYYERLHGLLDAIAESTDLDPIQKQNIIIMGGEANYLFEYSPSSPYRLAPVPREEWLTPEMASWSDADITTLLDVAESALRDCVKTMNLPALIMRKDRAVGIIPKTPESRIARESLEETVLVVQRILELSSLGSTDEHPAKPRPSSSPPLPPSVVSQSRRVPFCAFNGGRDVFVDIGDKSWGVTVCQQWFGSRESGGVIRGENTLHVGDQFLSAGSNDFKARSVGTTAWIASPAETVELLDELADLMQKKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNC1</accession>
    <name>C7YNC1_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_78177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053310.1">
        <property type="nucleotide sequence ID" value="XM_003053264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNC1"/>
    <dbReference type="STRING" id="660122.C7YNC1"/>
    <dbReference type="GeneID" id="9664376"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78177"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78177"/>
    <dbReference type="HOGENOM" id="CLU_883044_0_0_1"/>
    <dbReference type="InParanoid" id="C7YNC1"/>
    <dbReference type="OrthoDB" id="5087220at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU47597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="315" mass="35199" checksum="347CC42E97F78A9C" modified="2009-10-13" version="1">MATPHANDYPDRGVLCRLVLNEGDEIAIRYTRWMRWAMTDGPTQGSQSQLRTSAGTREAQAEIGFEIGRELAGCTDVMLKIAEYLLREFLAPDAEGSLLLGEIAESPFTALEPVWGCFNEFQGVSGPEAMPSFACNGQNVVTYSARVSGLAGVLLSIHAHETWQDTSMYDTEPGDDDAWSCMPMDDGEVMTEMWEGMETDGYTWSIRIETTKTRTFCIEDVSPWPTNFYDRATWKLAAKLCFSHLQCSKTWLGEVWLDGLQQSAMAAERDMMLLGFKHDDVQTEDFCPCVAKMAFEPLGMVLEDVLVVSLMGRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7YP43</accession>
    <name>C7YP43_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tetrapyrrole biosynthesis uroporphyrinogen III synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_37766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051495.1">
        <property type="nucleotide sequence ID" value="XM_003051449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YP43"/>
    <dbReference type="FunCoup" id="C7YP43">
        <property type="interactions" value="154"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YP43"/>
    <dbReference type="GeneID" id="9672846"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_37766"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_37766"/>
    <dbReference type="eggNOG" id="KOG4132">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051874_0_0_1"/>
    <dbReference type="InParanoid" id="C7YP43"/>
    <dbReference type="OMA" id="IHGADTG"/>
    <dbReference type="OrthoDB" id="5595751at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10090:FF:000011">
        <property type="entry name" value="Uroporphyrinogen-III synthase (UroS), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390">
        <property type="entry name" value="UROPORPHYRINOGEN III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390:SF0">
        <property type="entry name" value="UROPORPHYRINOGEN-III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="HemD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrapyrrole biosynthesis uroporphyrinogen III synthase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU45782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="313" mass="34076" checksum="32746AB471191FED" modified="2009-10-13" version="1">MTSSSKVPVLLLKTRSSPGDSYEDLFSETSAAGASFAPQFVPVLLHQFQDEGMKKVAEVLREGRIGNKEHHEYGGLIFTSQRAVEAFVKLVQDGKDENDSIKNDPPTSWPHLQHIPVYSVGPATTRALAAVPQDPPLSVFGSHTGNGATLAPYILSHYREWHAGRPSLPPVLFLVGETRRDIIPKTLQDPGLPDGERIAVDETVVYGTGVMESFPIDLDRVLSETQDAPARWVVVFSPTGCDSLLQVMGVLDPETGKVREGSVRDGKTYVATIGPTTRDHLKSFGFEPDVCAESPTPQGVLDGIQEFMTRNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7YP91</accession>
    <name>C7YP91_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_78677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051970.1">
        <property type="nucleotide sequence ID" value="XM_003051924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YP91"/>
    <dbReference type="STRING" id="660122.C7YP91"/>
    <dbReference type="GeneID" id="9673123"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78677"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78677"/>
    <dbReference type="eggNOG" id="ENOG502SDT6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037053_0_0_1"/>
    <dbReference type="InParanoid" id="C7YP91"/>
    <dbReference type="OMA" id="FRQHICH"/>
    <dbReference type="OrthoDB" id="5273928at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU46257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="454" mass="51081" checksum="60BED719DD16025A" modified="2009-10-13" version="1">MAATFDQETGQVFKEYVLSRDALTEADRDAADWSRRRRYPAVTARGVRGPRSLANMVIKVVADNIGSVGSVADLEDLPPRLLWRIWRFLEARGECLHAWKLFSKLFLEAEDDKTLSLYRFRQHICRPGNELTRYTVPLTAPPTDFITHLVLTGGCSFNTHDLLCLADMPNLGALELIQPADELRTIFPQVSDRLVRGWTEKSDPFPLLRILRIWGDQSTTKKSLQWVSQFPSLALYDVMGAREDWKQSEEAALEHGWEQAEKVSGLEDSLLRYLMLFAPLEEARTHRLSDLAARIDNDLVSLCGDSRCAVKFVQDRQAPPLLDYLTDMAKVRAPSWDIHAASGEARACHGVAFEPWAFWLYSFLGQLSSDRDLQARGALPPQKAVAGPFILPSRPFACLHLGHSTRGSGINTRPSYPIPKKGPSLVASERAAPVLALRKHKKRRLEDVLQAMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQB5</accession>
    <name>C7YQB5_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_100070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051707.1">
        <property type="nucleotide sequence ID" value="XM_003051661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQB5"/>
    <dbReference type="GeneID" id="9668936"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100070"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100070"/>
    <dbReference type="eggNOG" id="ENOG502S40Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052208_0_0_1"/>
    <dbReference type="InParanoid" id="C7YQB5"/>
    <dbReference type="OMA" id="RYNEDRA"/>
    <dbReference type="OrthoDB" id="5419542at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="192"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU45994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="346" mass="39195" checksum="912D434E4161B21C" modified="2009-10-13" version="1">MATAGAFTGPRDSTNSVSSIRSGSRHQLKRSITELTSPVKLSRRKEKERERDRDRYHDDRTPPSHYISISHPVSVSPYYQGRASVEIMPRSEGVTPMISPDQSRRPSVMLAREEENRNGNAAVPVEPKLNKEEKLKEDQTKSSSQVEGLKQSLVELGTFSTSTARRLDETYYAVLEKMTTLQSTVSVLKELAEESQSIHNNFEKDAREIENDITAQIAAMGQFEEHQNNIESLQARIQDGRSRIRALSERVDIVRERVERWERLDKESQDKTRLRLRAIMICMSVIMLTMLVLFFGAQYLSPNGDIIEDLARISWLKDVTALVSAKAVVYNHAAGSEAIFTVQSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQY4</accession>
    <name>C7YQY4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_60311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052267.1">
        <property type="nucleotide sequence ID" value="XM_003052221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQY4"/>
    <dbReference type="GeneID" id="9673720"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_60311"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_60311"/>
    <dbReference type="eggNOG" id="ENOG502QSKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_0_2_1"/>
    <dbReference type="InParanoid" id="C7YQY4"/>
    <dbReference type="OMA" id="WNLLHIT"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU46554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="348" mass="39472" checksum="8720399AF1E181DB" modified="2009-10-13" version="1">MAQAERTPSPQQLNVDPEWIEPDENDSSVGSETASSTTSISESILEYRKLHGRTYQNFNTGTEYWGPNDDRQNEGLELSHHMLYLALDNKLFLAPIGDNPQRVIDIGTGTGIWAIDFADQFPSAEVIGTDLSPIQPPWVPPNCKFELDDAQLPWPYPDNHFDYVHIRVLMGAIKDWPALYKEIYRCLKPGGWFEHLDYSIDVRSDDNSIPEDSPLNGWGDLFQKAGERMGRSFKIIEDGQSLQWLKDTGFTAVNEHRFKLPTGGWAADKKWKEIGHCNLLITENSLEGYVLFLLTQVMGWEVSEVQVFLAKTRKALRDKSIHSYAEVATVWGQKPLNEKKEASPTTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7YR79</accession>
    <name>C7YR79_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_100483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051120.1">
        <property type="nucleotide sequence ID" value="XM_003051074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YR79"/>
    <dbReference type="GeneID" id="9665765"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100483"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100483"/>
    <dbReference type="eggNOG" id="ENOG502SEM6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020940_0_0_1"/>
    <dbReference type="InParanoid" id="C7YR79"/>
    <dbReference type="OMA" id="HGTYKND"/>
    <dbReference type="OrthoDB" id="4096268at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051176">
        <property type="entry name" value="Cent_Immune-Sig_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715:SF37">
        <property type="entry name" value="LD47843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="39"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="485"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU45407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="764" mass="84324" checksum="0087D1A4124577D1" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7YR98</accession>
    <name>C7YR98_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxymuconolactone decarboxylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_104429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051133.1">
        <property type="nucleotide sequence ID" value="XM_003051087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YR98"/>
    <dbReference type="GeneID" id="9667828"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_104429"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_104429"/>
    <dbReference type="eggNOG" id="ENOG502RZ3K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082760_2_0_1"/>
    <dbReference type="InParanoid" id="C7YR98"/>
    <dbReference type="OMA" id="RVAVCNK"/>
    <dbReference type="OrthoDB" id="9998495at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846:SF11">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxymuconolactone decarboxylase-like" evidence="1">
        <location>
            <begin position="44"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU45420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="199" mass="22230" checksum="B90DE81554FD610A" modified="2009-10-13" version="1">MRIPYVPTPVPTKNDEEAAIVKRIEERRNPRPLQSLDLALLHSPPVADGWNSFLGAVRTKTSLSDDLRELAISRVAVCNEAWYEWKHHAPLAVKGGVSEAGLEAIKQDTLGERPAELSEKQWAVLLYTDEMTRNVHVKDETFDHLKKFFNEQEIVEITATVACYNCVSRFLVALDGKSKLTNQILGERNGTGPEAVSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRB2</accession>
    <name>C7YRB2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_40504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051139.1">
        <property type="nucleotide sequence ID" value="XM_003051093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YRB2"/>
    <dbReference type="GeneID" id="9667834"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_40504"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_40504"/>
    <dbReference type="eggNOG" id="KOG2362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028286_3_0_1"/>
    <dbReference type="InParanoid" id="C7YRB2"/>
    <dbReference type="OMA" id="RYGFCYG"/>
    <dbReference type="OrthoDB" id="17255at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="MOSC" evidence="2">
        <location>
            <begin position="193"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU45426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="390" mass="43673" checksum="EC707420F4366F5D" modified="2009-10-13" version="1">MSSLGVAGDGIIVITLLLVALTTLALVLSSRPHDGDKLEVTQLYVYPVKALRGSPMKEVRIGKYGVVGDRTFSLQKVHRDEKTGETKYETMLAGYYLQLMLFQASIDYNQDQGPEVVVTWHGRGTEFDKAKDVKTPDEIRFPLHPSTKGRKEFETSLHASKAMAVEMDNKLSTWFSDRLGFETLLVYIGDGSRPVLGSMAPNSKSGLTRSRLTRRIQSLLPGLAHPPESLVFNDIAHYLVVTEESNDQVTSRLDEGYTMDVTKFRPNIVVRGASGAFVEDYWGELTFDGDIQMPLTANCYRCQSITVDYDTGKTATDDRGMAWKKLNKDRRVDKGAKYSPVFGRYGYCFGSSLGKKIRVGQKAKVTYINKDRTTFDWPHLTSFGITQTKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-12-14" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRT4</accession>
    <name>RU1C_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">U1 small nuclear ribonucleoprotein C</fullName>
            <shortName evidence="1">U1 snRNP C</shortName>
            <shortName evidence="1">U1-C</shortName>
            <shortName evidence="1">U1C</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">NECHADRAFT_80502</name>
    </gene>
    <organism>
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">U1 snRNP is composed of the 7 core Sm proteins B/B', D1, D2, D3, E, F and G that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins U1-70K, U1-A and U1-C. U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the U1 small nuclear ribonucleoprotein C family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050842.1">
        <property type="nucleotide sequence ID" value="XM_003050796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YRT4"/>
    <dbReference type="SMR" id="C7YRT4"/>
    <dbReference type="STRING" id="660122.C7YRT4"/>
    <dbReference type="EnsemblFungi" id="NechaT80502">
        <property type="protein sequence ID" value="NechaP80502"/>
        <property type="gene ID" value="NechaG80502"/>
    </dbReference>
    <dbReference type="GeneID" id="9668001"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_80502"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_80502"/>
    <dbReference type="eggNOG" id="KOG3454">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079697_2_0_1"/>
    <dbReference type="InParanoid" id="C7YRT4"/>
    <dbReference type="OMA" id="QMRPPLM"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000059">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03153">
        <property type="entry name" value="U1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017340">
        <property type="entry name" value="U1_snRNP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148:SF1">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037969">
        <property type="entry name" value="U1_snRNP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000414289" description="U1 small nuclear ribonucleoprotein C">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="Matrin-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="204" mass="20666" checksum="304E264C3FA807A7" modified="2009-10-13" version="1">MPKFFCDYCDVYLTHDSMSVRKAHNSGRNHLRNVVDYYQQIGHEKAQSVIDSITSSYAAEGQAHANPMLPQNQPGQGFPPPPFGFPGGIPPPFPGMPGAPPGQFPQGMPPPPGGGRGMPPMPPFPPGPNGMPVPPNGLPFPPPGGFPFPPPGAPGAPGAPGASGGAPPPFPGLPGMPPPGQGFPPGGPPGFAPPGAGAPGHEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7YTF4</accession>
    <name>C7YTF4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Altered inheritance of mitochondria protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_84565</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM6 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049948.1">
        <property type="nucleotide sequence ID" value="XM_003049902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YTF4"/>
    <dbReference type="FunCoup" id="C7YTF4">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="GeneID" id="9675110"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84565"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84565"/>
    <dbReference type="eggNOG" id="ENOG502QVA8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031561_1_0_1"/>
    <dbReference type="InParanoid" id="C7YTF4"/>
    <dbReference type="OMA" id="HWGCTGV"/>
    <dbReference type="OrthoDB" id="4153866at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU44235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="341" mass="37544" checksum="1C0F516E07B8F03A" modified="2009-10-13" version="1">MASRKPKARNEANKAATRLTAQLNPYVFALGMVGAALSTMALVLALIVGVTPLIWSQSPSSSSVESTADLTLGLGSALPIPCHSHNDYWRRIPFYSAINAGCIGIEADVWVVRGELLVGHNLGSLSSGQTLTSMYIQPLVELLQTKNSVKDPNIPFRGVYDHDPSQTLVLLVDLKADPNSSWPLLLERLEPLRQRGWLSHVNNGAFISRPITVVGTGDTEVRLVNEETPFRDVFFDAPLNELEEGEFSSLNSYYTSVSFEKTIGKIGRGGLQPEQLAKLRNQISQAHSRGLKARYWGMPYWPIDVRDQLRELLIDEGVDVLNADDLVEAKGIFAKRGHLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7YU44</accession>
    <name>C7YU44_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_101631</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050063.1">
        <property type="nucleotide sequence ID" value="XM_003050017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YU44"/>
    <dbReference type="STRING" id="660122.C7YU44"/>
    <dbReference type="GeneID" id="9665423"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101631"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101631"/>
    <dbReference type="eggNOG" id="ENOG502QRA1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008869_0_0_1"/>
    <dbReference type="InParanoid" id="C7YU44"/>
    <dbReference type="OMA" id="HVVHSKI"/>
    <dbReference type="OrthoDB" id="3248508at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd06503">
        <property type="entry name" value="ATP-synt_Fo_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
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        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842:SF3">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="3">
        <location>
            <begin position="89"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="379"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="491"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="577"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="398"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="539"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="584"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU44350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="730" mass="80941" checksum="4C6D445E9F1D04BE" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7YV31</accession>
    <name>C7YV31_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_105396</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050223.1">
        <property type="nucleotide sequence ID" value="XM_003050177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YV31"/>
    <dbReference type="FunCoup" id="C7YV31">
        <property type="interactions" value="1073"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YV31"/>
    <dbReference type="GeneID" id="9674582"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_105396"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_105396"/>
    <dbReference type="eggNOG" id="KOG2086">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029402_4_1_1"/>
    <dbReference type="InParanoid" id="C7YV31"/>
    <dbReference type="OMA" id="NKDHTDK"/>
    <dbReference type="OrthoDB" id="25887at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:membrane fusion"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:nuclear membrane reassembly"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBX domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.210">
        <property type="entry name" value="SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036241">
        <property type="entry name" value="NSFL1C_SEP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012989">
        <property type="entry name" value="SEP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333:SF20">
        <property type="entry name" value="NSFL1 COFACTOR P47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333">
        <property type="entry name" value="UBX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08059">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00553">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102848">
        <property type="entry name" value="NSFL1 (p97 ATPase) cofactor p47, SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51399">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEP" evidence="3">
        <location>
            <begin position="207"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="324"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU44510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="43510" checksum="0134430AAF4ADEF7" modified="2009-10-13" version="1">MADHESQIVDFVGLTGGSTEEAKQYLEAHNWDIAEASNAWFRDAEDDANDPVPDNYTGPRTLDGRPAPAAASSSSSQARKPVSQQKKKGIATLGSLGGGSHQHDHDDDDDDMDDEDDDGRGNLFAGGEKSGLAVQDPHQEGGPKKIISDILAKARASNASRPDTENESGPSQPSRFRGTGMTLGGDGVESRSIPDPLGPSRPSNAQPQERVLHIWQDGFSIDDGELRRFDDPANQVDLQMIRSGRAPLHLMNVQHDQPVDVKLHQHDTPYQPQPKQYKPFGGSGRRLGAVVPGAGEETTPAPASAPVSAPTASSSTNTGPTIDESQPTVMIRIQMPDGTRLPARFNTTNTVDDVYGFVQGASPETRTRSWVLATTFPNKDHTDRSLVLGEMPEFKKGGTAVVKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVP5</accession>
    <name>C7YVP5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_74031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU43828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049541.1">
        <property type="nucleotide sequence ID" value="XM_003049495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVP5"/>
    <dbReference type="STRING" id="660122.C7YVP5"/>
    <dbReference type="GeneID" id="9677322"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74031"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74031"/>
    <dbReference type="eggNOG" id="ENOG502RR67">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_391317_0_0_1"/>
    <dbReference type="InParanoid" id="C7YVP5"/>
    <dbReference type="OMA" id="CNTINMA"/>
    <dbReference type="OrthoDB" id="3477286at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="169"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU43828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="705" mass="80287" checksum="52CAE4E32AA7ECFF" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWA2</accession>
    <name>C7YWA2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_30012</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Cd(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48775"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU43927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049640.1">
        <property type="nucleotide sequence ID" value="XM_003049594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWA2"/>
    <dbReference type="STRING" id="660122.C7YWA2"/>
    <dbReference type="GeneID" id="9677430"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_30012"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_30012"/>
    <dbReference type="eggNOG" id="ENOG502QPP7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026885_0_1_1"/>
    <dbReference type="InParanoid" id="C7YWA2"/>
    <dbReference type="OMA" id="FKVMMQM"/>
    <dbReference type="OrthoDB" id="2338at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337:SF0">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0104">Cadmium</keyword>
    <keyword evidence="5" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU43927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="469" mass="52268" checksum="EA793FE449FCB06E" modified="2009-10-13" version="1">MASSDWAPSSWRSKPIKQAPSYPDPEPLASAVEELTGLPPLVHPNEIDALKAHLRDVAQGNAFLLQGGDCAELFDYCRQGPIESKIKLLLQMSVVLIWGTNKRVVRIGRMAGQYAKPRSSPTEIVQGKEVPSFKGDIINGFRLEDREITPARLVKAYHYSAATLNYIRAALASGIADLHRPLDWGLGHVRDPELKAKYSAIASSIQQTLRFLQVINARPGELDSVELFTSHEGLLLEYEQALTRLLEKPAPGARNRSPTPDGPAPRKEYYDTSAHFIWIGDRTRQIDHAHVEFFRGIANPIGVKVGPTTPASDLLSLLRTLNPDREPGKITLITRYGAGKVRELLPTHIRAVEDSEYRRTVVWQCDPMHGNTLSTDTGIKTRRFGDIYRELEETLRIHKEEGSYLGGMHLELTGDAVTECLGGSEGLDEDDLSTNYTSFCDPRLNEKQALELAFLVADHFSREQKKESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWL1</accession>
    <name>C7YWL1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Sulfhydrylase FUB7</fullName>
            <ecNumber evidence="13">2.5.1.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Fusaric acid biosynthesis protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">NECHADRAFT_103019</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-acetyl-L-homoserine + hydrogen sulfide = L-homocysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:27822"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="2.5.1.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-acetyl-L-homoserine + methanethiol = L-methionine + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10048"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16007"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="EC" id="2.5.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from O-acetyl-L-homoserine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.49" evidence="13"/>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU43978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049691.1">
        <property type="nucleotide sequence ID" value="XM_003049645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWL1"/>
    <dbReference type="FunCoup" id="C7YWL1">
        <property type="interactions" value="206"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YWL1"/>
    <dbReference type="GeneID" id="9677266"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_103019"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_103019"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_4_0_1"/>
    <dbReference type="InParanoid" id="C7YWL1"/>
    <dbReference type="OMA" id="NAFQIIQ"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003961">
        <property type="term" value="F:O-acetylhomoserine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071269">
        <property type="term" value="P:L-homocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000083">
        <property type="entry name" value="O-acetylhomoserine sulfhydrylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000035">
        <property type="entry name" value="O-succinylhomoserine sulfhydrylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797">
        <property type="entry name" value="HOMOCYSTEINE/CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797:SF2">
        <property type="entry name" value="HOMOCYSTEINE_CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="8 16 17" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="16">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00083302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEU43978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="454" mass="48822" checksum="A941D1D84E5CE0AC" modified="2009-10-13" version="1">MSDLSKNFETLQLHAGAEPDPTTHSRAVPIYATTSYVFDDSAHGARLFGLKEFGNIYSRIMNPTVDVFEKRIAALEGGAAALAAASGQAAQFIAINTLAHAGDNIVSTSNLYGGTYNQLKVFLPRLGIETKFVNGDKPEDIAAAIDDKTKAVYLESIGNPKYNVPDLEAIAKVAHEKGVPVVVDNTFGAGGYYIRPIDHGADIVVHSATKWIGGHGTTIGGVVVDSGKFDWLKHKDRFPQFHEPSDGYHGLKFYETFGAATFIIRARVEILRDLGATLNPFAAQQLLLGTETLSLRAERHAQNALALAKYLEASPYVSWVSYPGLESHPYHETAKKYLKRGFGGVLSFGVKGGGAGSEVVDGFKLISNLANVGDAKTLAIHPWSTTHEQLSDEEKLSSGVTEDLIRISVGIEHIDDIIADFEQSFKAAADATTKGEQQKVVVPEGKEAEAPTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7YX33</accession>
    <name>C7YX33_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lactase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_82876</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049226.1">
        <property type="nucleotide sequence ID" value="XM_003049180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YX33"/>
    <dbReference type="STRING" id="660122.C7YX33"/>
    <dbReference type="GeneID" id="9676907"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82876"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82876"/>
    <dbReference type="eggNOG" id="KOG2024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002346_0_0_1"/>
    <dbReference type="InParanoid" id="C7YX33"/>
    <dbReference type="OMA" id="HYEADIY"/>
    <dbReference type="OrthoDB" id="408320at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005990">
        <property type="term" value="P:lactose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050347">
        <property type="entry name" value="Bact_Beta-galactosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023232">
        <property type="entry name" value="Glyco_hydro_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023230">
        <property type="entry name" value="Glyco_hydro_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032312">
        <property type="entry name" value="LacZ_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323:SF1">
        <property type="entry name" value="LACTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16353">
        <property type="entry name" value="LacZ_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01038">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00719">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00608">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta galactosidase small chain/" evidence="6">
        <location>
            <begin position="764"/>
            <end position="1047"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU43513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1054" mass="118236" checksum="6DFFB259089A243E" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXB8</accession>
    <name>C7YXB8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methylisocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_45455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049273.1">
        <property type="nucleotide sequence ID" value="XM_003049227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXB8"/>
    <dbReference type="STRING" id="660122.C7YXB8"/>
    <dbReference type="GeneID" id="9676945"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45455"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45455"/>
    <dbReference type="eggNOG" id="KOG1260">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027389_3_1_1"/>
    <dbReference type="InParanoid" id="C7YXB8"/>
    <dbReference type="OMA" id="DRIGYHA"/>
    <dbReference type="OrthoDB" id="1923844at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905:SF13">
        <property type="entry name" value="CARBOXYVINYL-CARBOXYPHOSPHONATE PHOSPHORYLMUTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13714">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU43560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="34712" checksum="007979B1574279C0" modified="2009-10-13" version="1">MSPAQVTKNSRLNGSEYPYPLERGAQRNEAATRLRKMMVEAHIDPTKIVQHPIAWDGLTARLVEEAGFPMVFLGGYAVSASHGLADAGYLGFAEMVHRTLEVCRVVDVPVMVDGDTGYGNEVNVRRTVQGYAKAGAAGIMIEDQVSPKRCGHTKDKKVVSFDDAVSRIGAAVAARNEGVDIFILARTDAHIISYEEAIRRVKAFFDQGADAVAIEAITSADEMQRSRKDLGPDIPSFINIIEGGKTPSMSYDDLASMGYCSVAYPLTLLAAGIKAMRGALQGLLRKTESPDTIMRFEDVCSAVGFQEYWDLAEKLTKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZ15</accession>
    <name>C7YZ15_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-lysine N-methyltransferase EFM4</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor methyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EFM4</name>
        <name evidence="7" type="ORF">NECHADRAFT_46521</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048999.1">
        <property type="nucleotide sequence ID" value="XM_003048953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZ15"/>
    <dbReference type="FunCoup" id="C7YZ15">
        <property type="interactions" value="756"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YZ15"/>
    <dbReference type="GeneID" id="9665660"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_46521"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_46521"/>
    <dbReference type="eggNOG" id="KOG1271">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044783_1_0_1"/>
    <dbReference type="InParanoid" id="C7YZ15"/>
    <dbReference type="OMA" id="PTPSFQF"/>
    <dbReference type="OrthoDB" id="10069295at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03188">
        <property type="entry name" value="Methyltr_EFM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026635">
        <property type="entry name" value="Efm4/METTL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843:SF5">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE METTL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Methyltransferase" evidence="6">
        <location>
            <begin position="73"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU43286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="246" mass="27554" checksum="197E4FCD16F1465F" modified="2009-10-13" version="1">MSSSDNPQHLEPSKLGTKEYWDNLYTTEITNNTEDPSDIGTVWFDDSDAEAKILEFLEGLLEPEDPDSPALSQDNTSFLDLGCGNGSLLFSLREEDWTGRALGVDYSPKSVSLARQIATTKESENVEFQEWDVIAGPFDTVLNGSQAEGWDVVLDKGTFDAISLSDEKDAQGRRLCEGYRERVLQLVRRGGIFLVTSCNWTESELRSWFERRDGEGFDVVGRVEYRTFSFGGAKGQTISTLCFRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZT7</accession>
    <name>C7YZT7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-1,2-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_47799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048379.1">
        <property type="nucleotide sequence ID" value="XM_003048333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZT7"/>
    <dbReference type="STRING" id="660122.C7YZT7"/>
    <dbReference type="GeneID" id="9667456"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_47799"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_47799"/>
    <dbReference type="eggNOG" id="ENOG502QW40">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025462_3_0_1"/>
    <dbReference type="InParanoid" id="C7YZT7"/>
    <dbReference type="OMA" id="AWGFEVG"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="54662" checksum="D80BDFDD8D555F79" modified="2009-10-13" version="1">MRFQVDILHLDTGLALLAFGAVALVLLGIVQVRLRRDKLRHVDYSQQRHHGFTAGTTKKSASGLGYTNVFPPSQRAAAFPNAAVVDLTSDNKRILEMSKDYRLANPSSYIFSGFSVKEVFSLGDFPDNAKLSGVPLPSPLPNFNIDKAVPRPYRPLRWVYHQTMAFKKMDPDFWIELESTYRERMRQRQEVCAKHGREVIQALPGSELACKELMEMVIQFICTRYPNQFQLVGTTLVNHILGTKHDLKEHEPLHIIRDNVPEDFAIMLRDEKTGRYIFRAGIICSSIGWNLGRKMNQDLDVIHGPVPEYKEKMGFSMNRFFSKMPTSSPIQRGSWGLSQGQPLYVPGDPSKASLKYRGAPNPSLKPDDIFLRTDWQTLRRLPLSGAVVFNFKVLFTPITEFEDEPFIPSLMLKILNDGKENLMEHKATRHVEHVAKPTLEMYERLQIENGLIPCDWEPKTLDESPFFPTWEQKWRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1I9</accession>
    <name>C7Z1I9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CDC20/Fizzy WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_50794</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU41828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047541.1">
        <property type="nucleotide sequence ID" value="XM_003047495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1I9"/>
    <dbReference type="FunCoup" id="C7Z1I9">
        <property type="interactions" value="724"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z1I9"/>
    <dbReference type="GeneID" id="9671674"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_50794"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_50794"/>
    <dbReference type="eggNOG" id="KOG0305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014831_4_0_1"/>
    <dbReference type="InParanoid" id="C7Z1I9"/>
    <dbReference type="OMA" id="WSKNTDE"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000025">
        <property type="entry name" value="FIZZY-related 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF1">
        <property type="entry name" value="FIZZY-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="10">
        <location>
            <begin position="275"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="319"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="402"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="532"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="157"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU41828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="589" mass="65041" checksum="9AE277CE64CCF39B" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1T7</accession>
    <name>C7Z1T7_FUSV7</name>
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        <recommendedName>
            <fullName evidence="7">Protein YTP1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_2244</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU41881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047594.1">
        <property type="nucleotide sequence ID" value="XM_003047548.1"/>
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    <dbReference type="AlphaFoldDB" id="C7Z1T7"/>
    <dbReference type="FunCoup" id="C7Z1T7">
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    </dbReference>
    <dbReference type="STRING" id="660122.C7Z1T7"/>
    <dbReference type="GeneID" id="9671729"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_2244"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_2244"/>
    <dbReference type="eggNOG" id="ENOG502QW3E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012543_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z1T7"/>
    <dbReference type="OMA" id="ENYANHM"/>
    <dbReference type="OrthoDB" id="4005299at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018827">
        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10355">
        <property type="entry name" value="Ytp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="497"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2427" evidence="3">
        <location>
            <begin position="24"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Protein YTP1-like C-terminal" evidence="4">
        <location>
            <begin position="241"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU41881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="57929" checksum="9173E8E9E39FD447" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z297</accession>
    <name>C7Z297_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_73925</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51220"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:34718"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:133977"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 glutathione + H2O2 = glutathione disulfide + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16833"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="EC" id="1.11.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU42135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047848.1">
        <property type="nucleotide sequence ID" value="XM_003047802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z297"/>
    <dbReference type="FunCoup" id="C7Z297">
        <property type="interactions" value="714"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z297"/>
    <dbReference type="GeneID" id="9671812"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_73925"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_73925"/>
    <dbReference type="eggNOG" id="KOG1752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026126_7_2_1"/>
    <dbReference type="InParanoid" id="C7Z297"/>
    <dbReference type="OMA" id="IYTSPLC"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000026">
        <property type="entry name" value="Glutaredoxin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF18">
        <property type="entry name" value="GLUTAREDOXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="8">
        <location>
            <begin position="17"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU42135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="106" mass="11695" checksum="C11E0B296A81D889" modified="2009-10-13" version="1">MAEISQKVQQIIDDNAVVVFSKSYCPYCRQTKKTLDDLNTVYELLELDQIPDGSDIQDALEQISGQRTVPNVYIKQKHIGGNSDVQSLKSGGKLQNLLKEAGAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z2L1</accession>
    <name>C7Z2L1_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_87638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047208.1">
        <property type="nucleotide sequence ID" value="XM_003047162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z2L1"/>
    <dbReference type="GeneID" id="9676388"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87638"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87638"/>
    <dbReference type="HOGENOM" id="CLU_2085418_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z2L1"/>
    <dbReference type="OrthoDB" id="5093048at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU41495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="117" mass="12605" checksum="812F7D141ACD9223" modified="2009-10-13" version="1">MEGHYPSPVERIFPSDRSFLNIIMNATSSGAAFSLDQDDAPLTRMEAEYWTLYAESSVNIMKFFAIIALGLAAVVTAAPAPQLDCTRDGFFCEPCVNGKQQCVACADGTGLGLTRDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z2T7</accession>
    <name>C7Z2T7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial phosphate carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_105693</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047249.1">
        <property type="nucleotide sequence ID" value="XM_003047203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z2T7"/>
    <dbReference type="FunCoup" id="C7Z2T7">
        <property type="interactions" value="710"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z2T7"/>
    <dbReference type="GeneID" id="9675790"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_105693"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_105693"/>
    <dbReference type="eggNOG" id="KOG0767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039456_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z2T7"/>
    <dbReference type="OMA" id="EFLMIMT"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000024">
        <property type="entry name" value="MIR1p Mitochondrial phosphate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF12">
        <property type="entry name" value="MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="30"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="128"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="227"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU41536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="34202" checksum="92BF7CDBFBA011D3" modified="2009-10-13" version="1">MSATATTVNLDVLRQRSDVSTEPKKLSGLGLYSRFAFAGAVCCSVTHGGLTPVDVVKTRIQLDPATYNRGMIGGFRQVIQTEGAGALLTGIGPTLAGYFLQGGLKFGGYEFFKQQSINVIGYDNARNNRIAVYCVSGAAAEFFADIALCPLEATRIRLVSDPGFANGLVPGFTKIARQEGLAAFYSGFGPILFKQVPYTMTKFVFYEKVSEFAYSNFFDKAKTSDGMQTAINLGSGLIAGFAAAIVSQPADTMLSKINKTKGLPGESNTSRLIKIGRELGLRGSFSGIGARLFMVGAMSAGQFAIYGDLKKAMGATGGVEIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z2W8</accession>
    <name>C7Z2W8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="17">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">NECHADRAFT_87743</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="function">
        <text evidence="16">This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="17"/>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047444.1">
        <property type="nucleotide sequence ID" value="XM_003047398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z2W8"/>
    <dbReference type="FunCoup" id="C7Z2W8">
        <property type="interactions" value="467"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z2W8"/>
    <dbReference type="GeneID" id="9676184"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87743"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87743"/>
    <dbReference type="eggNOG" id="KOG0204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_9_3_1"/>
    <dbReference type="InParanoid" id="C7Z2W8"/>
    <dbReference type="OMA" id="YQFIVMW"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF346">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 17" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 17" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="391"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="881"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="914"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="952"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="988"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="19">
        <location>
            <begin position="84"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1047"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1057"/>
            <end position="1067"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00059328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EEU41731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1078" mass="117321" checksum="B1EAAC5BA5CCB3F2" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4L5</accession>
    <name>C7Z4L5_FUSV7</name>
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        <recommendedName>
            <fullName evidence="11">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_32931</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003046034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4L5"/>
    <dbReference type="STRING" id="660122.C7Z4L5"/>
    <dbReference type="GeneID" id="9678464"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_32931"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_32931"/>
    <dbReference type="eggNOG" id="KOG1601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021761_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z4L5"/>
    <dbReference type="OMA" id="AMEPAEM"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034757">
        <property type="term" value="P:negative regulation of iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000039">
        <property type="entry name" value="Siderophore transcription factor SreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF335">
        <property type="entry name" value="IRON-SENSING TRANSCRIPTIONAL REPRESSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="11">
        <location>
            <begin position="95"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="11">
        <location>
            <begin position="258"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="136"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="298"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="407"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="432"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="520"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU40367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="559" mass="59386" checksum="B970E8A2C5FCBB26" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z634</accession>
    <name>C7Z634_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">BZIP transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_19733</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Positive regulator of amino acid starvation-induced autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
            <location evidence="4">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SCOC family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045772.1">
        <property type="nucleotide sequence ID" value="XM_003045726.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z634"/>
    <dbReference type="STRING" id="660122.C7Z634"/>
    <dbReference type="GeneID" id="9678445"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_19733"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_19733"/>
    <dbReference type="eggNOG" id="ENOG502S4IZ">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102236_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z634"/>
    <dbReference type="OMA" id="HPIERSD"/>
    <dbReference type="OrthoDB" id="2163284at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019357">
        <property type="entry name" value="SCOC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21614:SF0">
        <property type="entry name" value="GEO08385P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21614">
        <property type="entry name" value="SHORT COILED COIL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10224">
        <property type="entry name" value="DUF2205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU40059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="13818" checksum="21A0F20852681039" modified="2009-10-13" version="1" fragment="single">EPVIHQPIPVRPGLPTRKSSGPLVVPRDSSAVGPLEPDFGPDDVRAMSPRRTSEDLDRMGKEARDEMKRHAKALQDSLLTIFNRIEAVREEHDKLDNNNKFLQKYIGDLMSTSKITASSSRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6I5</accession>
    <name>C7Z6I5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_90757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045850.1">
        <property type="nucleotide sequence ID" value="XM_003045804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6I5"/>
    <dbReference type="GeneID" id="9668048"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90757"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90757"/>
    <dbReference type="eggNOG" id="ENOG502SJFK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062856_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z6I5"/>
    <dbReference type="OMA" id="KGCWDPV"/>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="31"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU40137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="297" mass="32278" checksum="652E4BD5904985C0" modified="2009-10-13" version="1">MAAKTTVVVPHLGGIKAGYRLSGDAVDPSKPTVVLVNSMCTTSSLFDAQFSSKALTDAVNLLAIEPLGHGATSSPSDHFTYWDSAIMSLQVLEALGIDKAFALGTSQGGWIVVRMALLAPEKILGLLPLGTSMDYESSESREKGCWDPKTSLRPFYESWDSATPTPDFVVDQVWRGLVSSVGFGTNPSAETLSFWDETLKQVYSGDEGRRKLRTAVANLLERDGLLLRLRDVKCPVYWLQGPEDPVFGKNVPVEHIKLFTSSPEATITFVDGAGHYLSATSPKETEEAILKMVKKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z747</accession>
    <name>C7Z747_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ARP2106</name>
        <name evidence="3" type="ORF">NECHADRAFT_32425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046521.1">
        <property type="nucleotide sequence ID" value="XM_003046475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z747"/>
    <dbReference type="FunCoup" id="C7Z747">
        <property type="interactions" value="372"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z747"/>
    <dbReference type="GeneID" id="9668863"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_32425"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_32425"/>
    <dbReference type="eggNOG" id="KOG0676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015497_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z747"/>
    <dbReference type="OMA" id="RYIFEKT"/>
    <dbReference type="OrthoDB" id="74201at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="562"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU40808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="658" mass="71384" checksum="452D472D0DDDD3AA" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z762</accession>
    <name>C7Z762_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_76324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OMA" id="SMMELNG"/>
    <dbReference type="OrthoDB" id="5091083at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU40247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="181" mass="20268" checksum="83187DE99B729652" modified="2009-10-13" version="1">MDHDTVSAKPPRHWQPQPPPSWPGLGCPAPATIVAMAIILLVISIFISVLRQLLERRLAQRRGWFLETPSAPSPTTKPKRKKKDERKVRPVSELEIEGRQLLFPDTVTPGERVPLRDPHARGSLYDTFQLPTEHASRLKHARSMMELSGGNPLEGADEKDGSKKAKTIHLHGTINFIESID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7D8</accession>
    <name>C7Z7D8_FUSV7</name>
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        <recommendedName>
            <fullName evidence="4">Tafazzin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_58133</name>
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        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046569.1">
        <property type="nucleotide sequence ID" value="XM_003046523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7D8"/>
    <dbReference type="STRING" id="660122.C7Z7D8"/>
    <dbReference type="GeneID" id="9668354"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_58133"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_58133"/>
    <dbReference type="eggNOG" id="ENOG502S698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032824_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z7D8"/>
    <dbReference type="OMA" id="GTNYYSH"/>
    <dbReference type="OrthoDB" id="5278911at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU40856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="51045" checksum="CDAA7651FC39D94F" modified="2009-10-13" version="1">MPKKRNHIRSFKPTPAAFPTASSSGSSADKPSRSVNELLANLRRTSTGPSAAGAAASPSALPATAPSVPPAIREILQIPETPAPAPRHITRQRFDGHGRRLPAGPPPPGSWVSRGPADPSAEASSSSSRLSQRGLQDTCLPGTYLPSRGSMIDIVLRKLACDWSFHRVYNQYHLYFVPNHLKSALIRYVGIASEDGLSISDLKIILLPPPDTFDEDELDELATSNLEVNYLDLSGSIGRSMRLKDISDLLFPVKEQEPASELQESWDAAEAIPSPPRTLLPNLTHLSLALHPQHASSASWRQLISVSSKLTTLTHLSLAYWPEPCFTPRARMSTVATPQGGQIPYGGTNLYSHSLDHDWSEALLVLRMFSRNLYALEFLDLTGCSPWFKALCAESGHDFVNWSDSWGKITELRLYTGWTPGPDALPSEQASFRESIEIAKSVAKHVRTMRAGKGRFIAVEHDHLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7F8</accession>
    <name>C7Z7F8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_91011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046009.1">
        <property type="nucleotide sequence ID" value="XM_003045963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7F8"/>
    <dbReference type="GeneID" id="9668362"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_91011"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_91011"/>
    <dbReference type="eggNOG" id="ENOG502QPYF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018583_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z7F8"/>
    <dbReference type="OMA" id="FFKHMPT"/>
    <dbReference type="OrthoDB" id="5397682at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604:SF3">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU40296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="677" mass="75397" checksum="59026CE40C2640A6" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7H8</accession>
    <name>C7Z7H8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alpha-aminoadipate reductase</fullName>
            <ecNumber evidence="6">1.2.1.31</ecNumber>
            <ecNumber evidence="5">1.2.1.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">L-aminoadipate-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">NhLYS2</name>
        <name evidence="21" type="ORF">NECHADRAFT_76435</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) = L-2-aminoadipate + ATP + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46936"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.2.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12308"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>(S)-2-amino-6-oxohexanoate + NADP(+) + H2O = L-2-aminoadipate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12304"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.31" evidence="6"/>
    <dbReference type="EC" id="1.2.1.95" evidence="5"/>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046587.1">
        <property type="nucleotide sequence ID" value="XM_003046541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7H8"/>
    <dbReference type="FunCoup" id="C7Z7H8">
        <property type="interactions" value="701"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z7H8"/>
    <dbReference type="GeneID" id="9668372"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76435"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76435"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_19_1_1"/>
    <dbReference type="InParanoid" id="C7Z7H8"/>
    <dbReference type="OMA" id="ENDKFTM"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004043">
        <property type="term" value="F:L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014397">
        <property type="entry name" value="Lys2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03443">
        <property type="entry name" value="alpha_am_amid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF1">
        <property type="entry name" value="L-2-AMINOADIPATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001617">
        <property type="entry name" value="Alpha-AR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="20">
        <location>
            <begin position="638"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1158"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1158"/>
            <end position="1171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EEU40874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1187" mass="131024" checksum="953832AB4074AC9F" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7X6</accession>
    <name>C7Z7X6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_79592</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045614.1">
        <property type="nucleotide sequence ID" value="XM_003045568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7X6"/>
    <dbReference type="STRING" id="660122.C7Z7X6"/>
    <dbReference type="GeneID" id="9672514"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79592"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79592"/>
    <dbReference type="eggNOG" id="ENOG502S5VZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051118_0_1_1"/>
    <dbReference type="InParanoid" id="C7Z7X6"/>
    <dbReference type="OMA" id="EENDAPW"/>
    <dbReference type="OrthoDB" id="5342093at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF4">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="2">
        <location>
            <begin position="23"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU39901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="347" mass="38437" checksum="77A24FFE47B73AD4" modified="2009-10-13" version="1">MSRTPDIERGVDQGLRHDLLGFAALSSWMASDEDRELLVFRRFNEISARNLLYLQCELLALEGELSRWDKMVSSSGNTALEQAAETWEIMVEQANKDTQDAKKMVDLVAKLRVKMKEYHEALDLQSRVARLQHPNRRALEVARNELHGGPLGEDGSKPNPILGGEAKNYLDDEGDLVSLGAPVETDMLFKTLRAYWPGKEEVSRDGIRRISRFEERSITIAVALINIVIAIILLVGSITSLYFVSSPAAILGMISAFTIAFALSVGLMTNAKRAEIFAGSAAFAAVLVVFLIVKLAARPAELVDELRAATNVQFRLRHVVEISPDELEGFCVLDSLDEVVRPYLAPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8P1</accession>
    <name>C7Z8P1_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_43190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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                <person name="Rodriguez-Carres M."/>
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                <person name="Freitag M."/>
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                <person name="Nelson D.R."/>
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</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044826.1">
        <property type="nucleotide sequence ID" value="XM_003044780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9K3"/>
    <dbReference type="STRING" id="660122.C7Z9K3"/>
    <dbReference type="GeneID" id="9673811"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_43301"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_43301"/>
    <dbReference type="eggNOG" id="ENOG502S704">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074390_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z9K3"/>
    <dbReference type="OMA" id="IDACHHD"/>
    <dbReference type="OrthoDB" id="20681at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1230.10">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036748">
        <property type="entry name" value="MTH938-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007523">
        <property type="entry name" value="NDUFAF3/AAMDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192">
        <property type="entry name" value="NUCLEAR PROTEIN E3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04430">
        <property type="entry name" value="DUF498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64076">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="23973" checksum="5D92A5F8E0F10BC9" modified="2009-10-13" version="1">MASRSFIRPCSAQRVVRQALSQPIRPSYSSIAALRTSSPTLSYAPTQPVSCRRAFHEAPSRRKGEEPPAQAPPTNFGDLDILGNTPVPSTSVDVCMYDGFGLNSGATITDGNGVLLVDGEVFNWRPWEAKGSMNLTNKKGQFEIPAQAFALFDLIWPRPVGPSIMPLAPTTRRHLAELGMRVEILDTRNAASQFNLLATERGVSDVAAALIPIGWKDGIGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAF7</accession>
    <name>C7ZAF7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA hydroxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_94695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045382.1">
        <property type="nucleotide sequence ID" value="XM_003045336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAF7"/>
    <dbReference type="STRING" id="660122.C7ZAF7"/>
    <dbReference type="GeneID" id="9672162"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94695"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94695"/>
    <dbReference type="eggNOG" id="ENOG502SCSP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049925_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZAF7"/>
    <dbReference type="OMA" id="ATPAHYD"/>
    <dbReference type="OrthoDB" id="2328924at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40128">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40128:SF1">
        <property type="entry name" value="PHYTANOYL-COA HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU39669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="37427" checksum="9F242F9EEF0EDA91" modified="2009-10-13" version="1">MPHAQTATKTPTIDNVELYVNDGLLAPSEVTKLRVSYPDEPLEELYQRYITDGYVFVKGLLPREDVLAAREAYFTSMAPSGVLKPGTKTVDGIFDDSADPADYPGIGAGSFKNSRPGETNKSEIFVDAALKAHTEAWYSGSEDGSVRGFCNHPALKDFVARLTGWGDATLAVRRTLLRNNTPGNKAIGVHYDQSFMRYGEPTAMTAWVPMGDVKVDGGGLIYLEGGDKLGADIEDDFARKAKAAGMNDEEMRNAFNSNMMSTGFLSEGPADFGRTYGKKWLVSEYEAGDVVFHTPHMIHASTINHDPSGRIRLGTDLRFVNSKRPWDTRWNKDYEFGDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAP2</accession>
    <name>C7ZAP2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_82165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045427.1">
        <property type="nucleotide sequence ID" value="XM_003045381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAP2"/>
    <dbReference type="GeneID" id="9672382"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82165"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82165"/>
    <dbReference type="HOGENOM" id="CLU_1058020_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZAP2"/>
    <dbReference type="OrthoDB" id="5092293at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="263" mass="28426" checksum="7C319B84FF24EF43" modified="2009-10-13" version="1">MAPSKGKEKKPTAVPSAKSARITRSKHLQKQLKQKKASLERASTAYNKASPEKQREINGMRNEVTTFRAVAESMVIDPPNQGPNEKRDTLQDNAGLEGTNGNNGSLSPIGPPSGNSTSSFQNDNSSKAPRNLGGDGENEPRHEPRAADKGGQLQEPETGRGGIGPNVIESIEADEPNGSLFLQDNNETTEFKDPEYSKPLLTIPTTSGVSEEATYRLENHAFPRSYAENPPEDKNVGSAKNRFGDTLPGIGRLHYPNAEAPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAW0</accession>
    <name>C7ZAW0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_83036</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044501.1">
        <property type="nucleotide sequence ID" value="XM_003044455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAW0"/>
    <dbReference type="GeneID" id="9670800"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83036"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83036"/>
    <dbReference type="eggNOG" id="ENOG502T4P4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_717824_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZAW0"/>
    <dbReference type="OMA" id="FDRDVPC"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="3">
        <location>
            <begin position="203"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU38788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="385" mass="44812" checksum="25EF6A4D68FC4E05" modified="2009-10-13" version="1">MNGYIEWIDDDLLCFCDEDDICYCFESDSYDSESSESESESDSENSDSYDFDMAEPRHLSQRHASSGRSRLTSRSQHKSTSQTRQKSSSDGAKAGLAKNNILWPSERCNLRVRFLNGDKFDQETVKKCVTDHYNSIPMRLRFKFLEPGDPEHSDIRITFTDQSKCLIGRSAENHRGEPTMWLNMHRDSSMGAEARRAKRQYDILHEFGHALGMQHEHQHPECKVNWNMQVIQAKYGWSAEKVHDNFDRLTQGVKPAAYDHESIMHYPVEPGDTHSLVTYVPLATKLSEGDKKFLMAIYPKPTKGVKLPQKPPKVVTKKPMHDDYMVQRLTAQLVMQYWIQNAILETIKSEERRLRRAQKELEMMQYVFAPFVVNQVVMVPCYYWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZB89</accession>
    <name>C7ZB89_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pectate lyase</fullName>
            <ecNumber evidence="10">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_8181</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the polysaccharide lyase 3 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="10"/>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044365.1">
        <property type="nucleotide sequence ID" value="XM_003044319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZB89"/>
    <dbReference type="STRING" id="660122.C7ZB89"/>
    <dbReference type="GeneID" id="9672900"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_8181"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_8181"/>
    <dbReference type="eggNOG" id="ENOG502RYK9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044863_3_1_1"/>
    <dbReference type="InParanoid" id="C7ZB89"/>
    <dbReference type="OMA" id="YDRGTEC"/>
    <dbReference type="OrthoDB" id="441042at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004898">
        <property type="entry name" value="Pectate_lyase_PlyH/PlyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407:SF9">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03211">
        <property type="entry name" value="Pectate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU38652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="210" mass="21469" checksum="C1BF05FAEE25E8CD" modified="2009-10-13" version="1" fragment="single">PQADGTSVLDAPMTIAAGETFDGKNVMFDRGVSCTGQDEGGDSDAVFILEAGASLSNVIIGPNQIEGVHCNGGCTLTNVWWDAVCEDAFSIKKQADGETTTINGGGAKGAEDKVIQHNGGGTVVINDFTVSDFGKLYRSCGNCKEMPARHVKVSGGSASEGKVLVGINPNMGDTASISGISVTNVKEQCVAFNGVTDGSEPEKVGSCDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBU2</accession>
    <name>C7ZBU2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_88548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698916">
        <property type="protein sequence ID" value="EEU38470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044183.1">
        <property type="nucleotide sequence ID" value="XM_003044137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBU2"/>
    <dbReference type="GeneID" id="9670572"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88548"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88548"/>
    <dbReference type="eggNOG" id="ENOG502SKY7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002467_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZBU2"/>
    <dbReference type="OMA" id="HCISITA"/>
    <dbReference type="OrthoDB" id="5369347at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="951" mass="109098" checksum="9AF34881BB4DAFCE" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZC17</accession>
    <name>C7ZC17_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_88628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698916">
        <property type="protein sequence ID" value="EEU38515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044228.1">
        <property type="nucleotide sequence ID" value="XM_003044182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZC17"/>
    <dbReference type="GeneID" id="9670569"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88628"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88628"/>
    <dbReference type="eggNOG" id="ENOG502SV8M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_973470_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZC17"/>
    <dbReference type="OMA" id="HAGMRET"/>
    <dbReference type="OrthoDB" id="4270785at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="159"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="286" mass="32515" checksum="8ABE14A9CF8ACB34" modified="2009-10-13" version="1">MGSPADLPLATKSLRSRADLEDYVYNFNANNKAAYAAYYSKNTVFKFSTFPDRTLDEFLAWVDQIHACMRETLGLKKVVFGQNAVATEMHTQFRGINDFETDNLDGRWGPVWPGNGPLVRMFVWYTLDKDGHIIEVAEEASLMKEASRHVIRSRGDLDHYLRSFNTNDFDTFPRYYTPDVTIILNGEQTLNGKDEAVNFFRNAREKVNEEVNVQSIILDKDGVAIKSDIKFTAIMNIEDILHFGSGVRKGGGYRVQFLIYYELTPEGKMHHITAASCGQAKIFNPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCA2</accession>
    <name>C7ZCA2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_91440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the wax synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698918">
        <property type="protein sequence ID" value="EEU38334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044047.1">
        <property type="nucleotide sequence ID" value="XM_003044001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCA2"/>
    <dbReference type="GeneID" id="9670461"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_91440"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_91440"/>
    <dbReference type="eggNOG" id="ENOG502SI5I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032731_0_1_1"/>
    <dbReference type="InParanoid" id="C7ZCA2"/>
    <dbReference type="OMA" id="STAITCR"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF27">
        <property type="entry name" value="WAX SYNTHASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="8">
        <location>
            <begin position="246"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU38334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="434" mass="48647" checksum="B6A00214F0D948DE" modified="2009-10-13" version="1">MEDVNQGSVPINLIKGGFLLLIACIPTAFIMLATPKSGINSTPRYVWPIVVVAIGKRIFQMIADTGTSFVINGVIMGWVVLVLIQCCNVLIVRKLDSDELVRGNIFRLSDGFLDKFYFTMRLLFNLRNVGNPWEVKRLHKFPSYYKGPKPSRSAYITRQVLIMAWQYLLLDIIYMSSLETPPEDAQRLFGPGTEFNYLNATAEQWGGRVAVGPVAGLAPARVSIDIPYRGFSILSVLLGITSTDQWPPLFGSMWDAYTIRGFWNTFWHQDCLWPMKSLSNYICRDLLGLPRPSFIERYLNILIVFLASGAMHLTIDLFSYKPPSKAPTLAFFGSMALAIMLEDAVQDLCRRITGVDTRKKDVKVPLWHRLVGYVWVITWMTLTAPWYLAHAAQLPAETKWLVPFSLVSQIGLPAAGALLGVSGLILKYAIGGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCC0</accession>
    <name>C7ZCC0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_76998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698918">
        <property type="protein sequence ID" value="EEU38233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043946.1">
        <property type="nucleotide sequence ID" value="XM_003043900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCC0"/>
    <dbReference type="STRING" id="660122.C7ZCC0"/>
    <dbReference type="GeneID" id="9670383"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76998"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76998"/>
    <dbReference type="eggNOG" id="ENOG502REPI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015092_5_0_1"/>
    <dbReference type="InParanoid" id="C7ZCC0"/>
    <dbReference type="OMA" id="VTGQAWK"/>
    <dbReference type="OrthoDB" id="5242705at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="586"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU38233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="684" mass="75930" checksum="0ABC8D557C513F63" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCN5</accession>
    <name>C7ZCN5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ThuA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_34653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698918">
        <property type="protein sequence ID" value="EEU38400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044113.1">
        <property type="nucleotide sequence ID" value="XM_003044067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCN5"/>
    <dbReference type="GeneID" id="9670332"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_34653"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_34653"/>
    <dbReference type="eggNOG" id="ENOG502RZ2Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057383_1_2_1"/>
    <dbReference type="InParanoid" id="C7ZCN5"/>
    <dbReference type="OMA" id="FTDEWYD"/>
    <dbReference type="OrthoDB" id="3482285at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40469:SF2">
        <property type="entry name" value="GALACTOSE-BINDING DOMAIN-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40469">
        <property type="entry name" value="SECRETED GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThuA-like" evidence="1">
        <location>
            <begin position="17"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="242" mass="26932" checksum="CE1BA14B8183C1FE" modified="2009-10-13" version="1">MTTVDRVPETPQQPRLRVLALSKTAGYRHECIPASIAALRVLGDRTRLFNLVSTEDASILSPDTLAGYATVIFLHTTGPFLNDVQLAALQSYVRAGGGFIGVHAAASGNKESEWYGRLVGAHFDYHPTPEEGTLVIEDAGHEIMSGNSVGERRWMDEWYNFKTHPRENANLHVLVRGDTSSFQGGNMGDDHPLVWCQEFEGGRSFYTALGHFDEAYEDEWFMGQLERAIVWTADAGKRETDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDN3</accession>
    <name>C7ZDN3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">NECHADRAFT_54993</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043569.1">
        <property type="nucleotide sequence ID" value="XM_003043523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZDN3"/>
    <dbReference type="STRING" id="660122.C7ZDN3"/>
    <dbReference type="GeneID" id="9669762"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_54993"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_54993"/>
    <dbReference type="eggNOG" id="ENOG502RY3D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031730_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZDN3"/>
    <dbReference type="OMA" id="NDWPSSH"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF36">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988750" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="17">
        <location>
            <begin position="22"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="18">
        <location>
            <begin position="335"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="252"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="258"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEU37856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="371" mass="38938" checksum="FDEC0D3E54800CA8" modified="2009-10-13" version="1">MTFFKTSSLLAFAYSAAKVAAHGHVDWLITNGVAFRGYDAPAMSWNPNQPPVVGWITGATDNGYVEPNSFSDPDIICHRAARPAKGHVTVEAGDKVVLQWNTWPESHKGPVIDYLAKCPGDCETADKNSLEFFKIGESGLLDMTMQSGRWAADVLVANSFSWTLQIPAQLEPGNYVLRHEIIALHGAGQTNGAQNYPQCFNLKVTGGGSLAPSGVKGTQLYKSNDPGILFNLYTSSLSYKIPGPTLVPGLPSTVGQLAPQATATSSATTPGQTQGPSSTSTTRSSSSTSLTISGVTTLRTVTATTTSSSSSSSSSSSKASPSPTDDDIICGPATGGLPKYSQCGGKDYTGPTVCQWGSTCQVLNPYYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEG3</accession>
    <name>C7ZEG3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_53386</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698921">
        <property type="protein sequence ID" value="EEU37671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043384.1">
        <property type="nucleotide sequence ID" value="XM_003043338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEG3"/>
    <dbReference type="STRING" id="660122.C7ZEG3"/>
    <dbReference type="GeneID" id="9665383"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_53386"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_53386"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="InParanoid" id="C7ZEG3"/>
    <dbReference type="OMA" id="LPNFNWG"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF562">
        <property type="entry name" value="ALDEHYDE REDUCTASE II (AFU_ORTHOLOGUE AFUA_1G11360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU37671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="363" mass="39855" checksum="296CCC56857662C1" modified="2009-10-13" version="1">MAPLDNLAVPKGSTVLVTGANGLLGSHISKQFLEFGYNVRGTVRNPEKNAWLKTAFDKEYGQGRFEFFQVPDMVAEGAFNEAVKGVAVVAHSASIMSLDPNPNNVIPGVIAGAINALKAAYAEPSVKRFVYTSSSSATVIAEPSQTGINVTEETWNEDSIKKAWADPPYTMERAADTYGASKAQAEQEVWKYYKEHRDERPDIVVNTVLPNFNFGRSIDPANQGYPSSSALPALLYNGLVTGVHHLVVPQYFVDVDDTGRLHVAAGILDHVKGQRIFAYGGRFNWDEVLEVLRKTEPSKTFPENFSGGRDANEYEGRAKAEQLLRDLGRPGWTTLEETIVATVEGLREAGDKLKVRDYEELGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEH4</accession>
    <name>C7ZEH4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_102134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698921">
        <property type="protein sequence ID" value="EEU37596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043309.1">
        <property type="nucleotide sequence ID" value="XM_003043263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEH4"/>
    <dbReference type="STRING" id="660122.C7ZEH4"/>
    <dbReference type="GeneID" id="9669119"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102134"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102134"/>
    <dbReference type="eggNOG" id="ENOG502RM5M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_689041_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZEH4"/>
    <dbReference type="OMA" id="FEDMFRF"/>
    <dbReference type="OrthoDB" id="5953249at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="1">
        <location>
            <begin position="118"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="400" mass="46278" checksum="E850E4528968415B" modified="2009-10-13" version="1">MFARPRLPRPNAIRKCNPPSILAWPTIQTIRYSSFKRRRRSETHESAALARPSIQRSQRFQTTRVRGVKRRQSETHEPATLAWLLGYGDQVQPSGAPWPDLSKLVLENANLSLRNVRFLSIDIDGLHQDKAGIRQFDIGVSILDTEQIYQQLKLPPNRRKNLAVHLIKSRHYAVEDTRHDIAKRINFSFGGCRVMSLPKLRQKLKDKVEGRNVVLVMHGAATEVSVMKSLNINLNPVFTIDTTTTVRHLFRRTNLKHLLEVYRIPHKSRSLHHAGNDAHFILRVLLMIAVHHVRAKLGGAQLPDWVPVFETVARSPKPELEEMRKEGPLRITPGHKELKQMERRRETLERIARRLEKPSKEEEEMMPWRMVQVQPTLPDCDAMSPPWADRYTISQYGMLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEM4</accession>
    <name>C7ZEM4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sequence orphan</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_7367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698921">
        <property type="protein sequence ID" value="EEU37723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043436.1">
        <property type="nucleotide sequence ID" value="XM_003043390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEM4"/>
    <dbReference type="GeneID" id="9669321"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_7367"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_7367"/>
    <dbReference type="eggNOG" id="ENOG502QWAD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054095_2_0_1"/>
    <dbReference type="InParanoid" id="C7ZEM4"/>
    <dbReference type="OMA" id="WFASKPF"/>
    <dbReference type="OrthoDB" id="275936at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038781">
        <property type="entry name" value="C365.16-ike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37845">
        <property type="entry name" value="SEQUENCE ORPHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37845:SF1">
        <property type="entry name" value="SEQUENCE ORPHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU37723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="21195" checksum="A363AAB7AE736500" modified="2009-10-13" version="1" fragment="single">LVYFGTYATANLFDSFNAIQHDLDPSIVCSTPAKFAATTTVSSSLCIFKDAYFSRMASGAPVPLLSYALFSLRDAVTIYASFNLPNMLAPKLAEFPFSSITPFAEIFKSDESRLKMAQLFMPAASQIVSTPMHLLGLDLCARRSWMPIRERLSVIRQYTGFAAPLRMMRALPSFGIGSVANTGFRKSMMTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEW0</accession>
    <name>C7ZEW0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HAD family hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_51589</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043086.1">
        <property type="nucleotide sequence ID" value="XM_003043040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEW0"/>
    <dbReference type="STRING" id="660122.C7ZEW0"/>
    <dbReference type="GeneID" id="9665284"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51589"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51589"/>
    <dbReference type="eggNOG" id="KOG3085">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_8_1_1"/>
    <dbReference type="InParanoid" id="C7ZEW0"/>
    <dbReference type="OMA" id="CNFFDHI"/>
    <dbReference type="OrthoDB" id="444127at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051400">
        <property type="entry name" value="HAD-like_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46470">
        <property type="entry name" value="N-ACYLNEURAMINATE-9-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU37373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="28165" checksum="405A38619C312B3A" modified="2009-10-13" version="1">MEPTTTKVVFFDLDGTLFDHDHSLRLAISTMQLLYPILAGKNVEELVDKYNTALQQAYDEYLDKAITFEEANTRKVHLFFTALSLPKPSLDEVNEFRGGYKTIYRANRRATPGSVETLLRLRKHGYRICIITNGQTEDQAAKAEAIGIRHLVDRIITSEEAGYQKPDLRIFQYAMQQLNASPHAIMVGDSADSDIKGALDAQLTAIMYLPTTQESQRLLFGQQVPVIQHMSQLLKHFDIPSTTPSSFKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEY2</accession>
    <name>C7ZEY2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_51324</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the germin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043188.1">
        <property type="nucleotide sequence ID" value="XM_003043142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEY2"/>
    <dbReference type="STRING" id="660122.C7ZEY2"/>
    <dbReference type="GeneID" id="9665293"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51324"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51324"/>
    <dbReference type="eggNOG" id="ENOG502QSRM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061239_3_0_1"/>
    <dbReference type="InParanoid" id="C7ZEY2"/>
    <dbReference type="OMA" id="EFNPDCG"/>
    <dbReference type="OrthoDB" id="1921208at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02241">
        <property type="entry name" value="cupin_OxOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001929">
        <property type="entry name" value="Germin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31238">
        <property type="entry name" value="GERMIN-LIKE PROTEIN SUBFAMILY 3 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00325">
        <property type="entry name" value="GERMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002989063" description="Cupin type-1 domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="7">
        <location>
            <begin position="74"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU37475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="258" mass="27166" checksum="F3E8C0DC96621541" modified="2009-10-13" version="1">MSMLLLAGTALAAPAAKSVAERANDSIDNVLPPIVPINTRSGDRDLIAKLITAPTQVERAKLLDQPGDYVFDFEAATGSGESKGKGGRSTSATALTMPALIGNGASMTVAFLGPCGMNTAHVHNRATELNIIVKGRLVTNFVIENGAKPIQNTMDTWQMSVFPKGAIHQEFNPDCEDAVFVAGFNDPDPGVNQIAQNFFSLNGDVVSATLGGVQTIDGKDIESFREVIPANIALGIDACLNKCGIKRNAKRSISEILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEY3</accession>
    <name>C7ZEY3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_51592</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043189.1">
        <property type="nucleotide sequence ID" value="XM_003043143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEY3"/>
    <dbReference type="FunCoup" id="C7ZEY3">
        <property type="interactions" value="279"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZEY3"/>
    <dbReference type="GeneID" id="9665294"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51592"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51592"/>
    <dbReference type="eggNOG" id="KOG0223">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020019_1_4_1"/>
    <dbReference type="InParanoid" id="C7ZEY3"/>
    <dbReference type="OMA" id="FWVGPIS"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF283">
        <property type="entry name" value="AQUAPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU37476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="28047" checksum="808437295268BF06" modified="2009-10-13" version="1">MATSDEAGVLDGPHHQQYQLSPVGRHLVAASGEFVGTFFFLYFGYAGNLMAALQAPDTAPNGGLASTTDIWIAVSYGFSLLVNAWAFYRISGGLFNPAVSLGLCVGGQLSWTRAAFLFPAQVLGSICAGGLVDAMFPGRVEQANTLLGLNTSIAQGVFLEMFFTAQLVFVVLMLAAEKSRDTFLAPVGIGLALFVALIPGVSVTGGSANPVRSFGCAVAGASFPGYHWIYWVGPALGATLAALYYRLVKRLHYEEANPGQDSPHEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZF28</accession>
    <name>C7ZF28_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_51304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043206.1">
        <property type="nucleotide sequence ID" value="XM_003043160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZF28"/>
    <dbReference type="GeneID" id="9665215"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51304"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51304"/>
    <dbReference type="eggNOG" id="ENOG502S8UP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034857_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZF28"/>
    <dbReference type="OMA" id="WNGHFAS"/>
    <dbReference type="OrthoDB" id="3140657at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42057">
        <property type="entry name" value="F-BOX DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42057:SF2">
        <property type="entry name" value="F-BOX DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00200)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="10"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="518" mass="59645" checksum="90EAB6A79EB55CA4" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFR2</accession>
    <name>C7ZFR2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">D-serine dehydratase</fullName>
            <ecNumber evidence="11">4.3.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">D-serine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NECHADRAFT_37272</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the conversion of D-serine to pyruvate and ammonia. May play a role in D-serine detoxification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13977"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="EC" id="4.3.1.18"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:13978"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DSD1 family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.18" evidence="11"/>
    <dbReference type="EMBL" id="GG698923">
        <property type="protein sequence ID" value="EEU37311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043024.1">
        <property type="nucleotide sequence ID" value="XM_003042978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFR2"/>
    <dbReference type="STRING" id="660122.C7ZFR2"/>
    <dbReference type="GeneID" id="9664976"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_37272"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_37272"/>
    <dbReference type="eggNOG" id="ENOG502QRZ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031639_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZFR2"/>
    <dbReference type="OMA" id="WVRASGW"/>
    <dbReference type="OrthoDB" id="20198at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036088">
        <property type="term" value="P:D-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000016">
        <property type="entry name" value="D-serine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.20">
        <property type="entry name" value="D-serine dehydratase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051466">
        <property type="entry name" value="D-amino_acid_metab_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026956">
        <property type="entry name" value="D-ser_dehydrat-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042208">
        <property type="entry name" value="D-ser_dehydrat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004:SF2">
        <property type="entry name" value="D-SERINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004">
        <property type="entry name" value="ZGC:162816-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14031">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01119">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0216">Detoxification</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="D-serine dehydratase-like" evidence="14">
        <location>
            <begin position="326"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00066349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU37311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="462" mass="50295" checksum="897FC351C8903376" modified="2009-10-13" version="1">MTLPQRFAPPHDELRQFYVGKDIHDVPKPAVILDVSRVQRHCQSMLEAVDALGVGFRAHVKTHKTIEGTRLQVGQGSGDIKLVVSTLAEIDHLLPLFKEYQDAGRHVDILYGIPLPPSQIPRLATLGSELGKGSISVMIDHPSQLDSIKCFSQQTKFPARVYLKVDTGYHRAGLPPTSLNKNGLIEALAQLEAQGEAELIGLYSHSSLSYKDSTPEQAMANLEGEIQGCLEAVHAQSHLFPNHEKITISVGASPQVTAIENLTNTEGDLSDTAQSLRRAIQTVSSGKPGGLQTTLELHAGVYSILDLQQTSTNSRRTLGSFEDEIAISVIAEVCSVYNDKERSQPEALVAVGVLGLGREPCPSYPGWGIVNKAHLKSQTNSERRLIIGRVSQEHAIVAWEHGKDEDTADLPPLPLEVGQSVVIFPNHACITGALYGWYLVVDSSDEENPTKIVDVWARASGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFV3</accession>
    <name>C7ZFV3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_5382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698924">
        <property type="protein sequence ID" value="EEU37041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042754.1">
        <property type="nucleotide sequence ID" value="XM_003042708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFV3"/>
    <dbReference type="GeneID" id="9664954"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_5382"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_5382"/>
    <dbReference type="eggNOG" id="KOG0742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004471_5_0_1"/>
    <dbReference type="InParanoid" id="C7ZFV3"/>
    <dbReference type="OMA" id="TERSEHM"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056599">
        <property type="entry name" value="AAA_lid_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF2">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23232">
        <property type="entry name" value="AAA_lid_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="246" mass="28363" checksum="2832A874FC871BF6" modified="2009-10-13" version="1" fragment="single">GRGCIILLHGVPGVGKTSTAGKFQQCVAVHTKKPLYPITCGDIGYRPEDVERNLGHHFRLAHKWGCVLLLDEADVFLAKRDAFFLRILEYYSGILFLTTNRVGAIDDAFRSRLHLTLYYPKLTKKQTKQIFKHNFERIADINTNRKLNGLPPFEYKDTEPKIMAWAMETWKALRWNGRQIRNAFQTVLALAEFYEKSRGDESAPRVVTKKYFKIVANASTQFNDYLLATHGMDEDKVANREYMRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZGG4</accession>
    <name>C7ZGG4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_42107</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698925">
        <property type="protein sequence ID" value="EEU36930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042643.1">
        <property type="nucleotide sequence ID" value="XM_003042597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZGG4"/>
    <dbReference type="STRING" id="660122.C7ZGG4"/>
    <dbReference type="GeneID" id="9670143"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_42107"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_42107"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_291348_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZGG4"/>
    <dbReference type="OMA" id="DQFKHHS"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd04469">
        <property type="entry name" value="S1_Hex1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037318">
        <property type="entry name" value="Hex1_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="231"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="331"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU36930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1006" mass="112977" checksum="6AD19C3FFD879E1B" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHJ3</accession>
    <name>C7ZHJ3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_42498</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698928">
        <property type="protein sequence ID" value="EEU36477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042190.1">
        <property type="nucleotide sequence ID" value="XM_003042144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHJ3"/>
    <dbReference type="STRING" id="660122.C7ZHJ3"/>
    <dbReference type="GeneID" id="9669221"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_42498"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_42498"/>
    <dbReference type="eggNOG" id="KOG3867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_11_1_1"/>
    <dbReference type="InParanoid" id="C7ZHJ3"/>
    <dbReference type="OMA" id="QARYMEI"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16025">
        <property type="entry name" value="PAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000044">
        <property type="entry name" value="Arylsulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.10:FF:000005">
        <property type="entry name" value="Arylsulfatase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF46">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G12940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="6"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU36477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="605" mass="68209" checksum="A1EEE11AA6CE1A35" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHW5</accession>
    <name>C7ZHW5_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_86888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698929">
        <property type="protein sequence ID" value="EEU36352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003042019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHW5"/>
    <dbReference type="GeneID" id="9674401"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86888"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86888"/>
    <dbReference type="eggNOG" id="ENOG502SHTJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024888_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZHW5"/>
    <dbReference type="OMA" id="YALWQVR"/>
    <dbReference type="OrthoDB" id="5287717at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="601"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU36352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="681" mass="76814" checksum="359F7CC4660F8082" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZIB6</accession>
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        <recommendedName>
            <fullName evidence="7">Peptidase S33 tripeptidyl aminopeptidase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_52885</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698930">
        <property type="protein sequence ID" value="EEU36177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041890.1">
        <property type="nucleotide sequence ID" value="XM_003041844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZIB6"/>
    <dbReference type="STRING" id="660122.C7ZIB6"/>
    <dbReference type="GeneID" id="9674252"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_52885"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_52885"/>
    <dbReference type="eggNOG" id="ENOG502RY03">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013364_5_0_1"/>
    <dbReference type="InParanoid" id="C7ZIB6"/>
    <dbReference type="OMA" id="APFETWD"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="72"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="4">
        <location>
            <begin position="405"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU36177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="58761" checksum="435B7FE5CA8EDCD2" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJ28</accession>
    <name>C7ZJ28_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_85339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698932">
        <property type="protein sequence ID" value="EEU35942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041655.1">
        <property type="nucleotide sequence ID" value="XM_003041609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJ28"/>
    <dbReference type="GeneID" id="9674058"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85339"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85339"/>
    <dbReference type="eggNOG" id="ENOG502RPP3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043982_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZJ28"/>
    <dbReference type="OMA" id="WLDPLHY"/>
    <dbReference type="OrthoDB" id="4737775at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="36756" checksum="6D0C86EFEFE3D26E" modified="2009-10-13" version="1">MAPARIEVTSAEDELSRRRERGRRSQAAFRKRQAQAAQGLSDQNRRLIEGVQKAVDAVHGDERQEILDAIANLANIAGLETKDSPLRDTPPSSGDEDITINVLTGDFTRNSKSSTGTCTQISSPTPQRLDCGIWLDPMHYKRVSLPPQDIIPYLGPGSKTFAGLLFWSVMDHSLNGCKHPHAEASTVIKTGLGHSTATQDVKVSFIRRMVEARLEFKKTGSISAEHASAAENDLGVVLRNLVETDYRARGKDPDLWLSCVAIEQRVRSIAGNSAFLVLEKAVRDEGEQELREALVRVKCRLSDTGVCFGDGPRWNVDVVDSIFLDPIIQAMGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJL1</accession>
    <name>C7ZJL1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_44322</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698935">
        <property type="protein sequence ID" value="EEU35758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041471.1">
        <property type="nucleotide sequence ID" value="XM_003041425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJL1"/>
    <dbReference type="GeneID" id="9676306"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_44322"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_44322"/>
    <dbReference type="eggNOG" id="ENOG502RX9H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027816_3_1_1"/>
    <dbReference type="InParanoid" id="C7ZJL1"/>
    <dbReference type="OMA" id="AGMFWLH"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF697">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="47"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU35758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="460" mass="49064" checksum="7876EA46D61EF5B3" modified="2009-10-13" version="1">MASSPTDSIQHSPEKGSPSRGSGEDLKTEVIEDGGEVFQQAEYRALGWIRTAIILSKLCFATGVLAIPSAFSIVGYGPGIILLVCWGALTTYYAYIMYAFRMRYSGVHNIADAAGLMGGPIAREVAGGLFLLTWILATGSGFIGLAQGFQVLSSKHVCTVVWTLVAAICTALVASIQTLGKLAILTWIGFASIFTAVFIVVVGVTQVDRPAAAPQEGSFDMEVLAVGAPTFIPGFVAAINLFAGYGSTPTFMPVIAEMKTPKSFTKALFSSQGFLVACYISFALVVYIRYCGQYVASPSLGSAGGTLEKIAYGVSIPGFIMTSTLWVHLAAKFLLVRILRNSEHLQNHSLIHWTVWLGSTIGISTVAFIIAGAVPFFSYLIGLIGSLCCAPTCLIIPAFMGLYMDWELRGTSKVKQALCYFHIFTVVLGAFMTVTGTYTTIQSIIDAYKLGTVGTPFTCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJQ8</accession>
    <name>C7ZJQ8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_44393</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698935">
        <property type="protein sequence ID" value="EEU35782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041495.1">
        <property type="nucleotide sequence ID" value="XM_003041449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJQ8"/>
    <dbReference type="GeneID" id="9673866"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_44393"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_44393"/>
    <dbReference type="eggNOG" id="KOG0253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_52_4_1"/>
    <dbReference type="InParanoid" id="C7ZJQ8"/>
    <dbReference type="OMA" id="SGWRYLM"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="64"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU35782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="516" mass="55908" checksum="28082C9AA960950B" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJW7</accession>
    <name>C7ZJW7_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_87960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698936">
        <property type="protein sequence ID" value="EEU35664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041377.1">
        <property type="nucleotide sequence ID" value="XM_003041331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJW7"/>
    <dbReference type="GeneID" id="9676173"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87960"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87960"/>
    <dbReference type="HOGENOM" id="CLU_1027087_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZJW7"/>
    <dbReference type="OrthoDB" id="10495438at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU35664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="271" mass="30063" checksum="29A8BB2A3C0566C0" modified="2009-10-13" version="1">MTGTVACLVTLVAISPGLCVILTRRPLRLPGDNSVPSQGIFIAILTSSQVFPVSFNQALTTCSRTSPPILVPVCGAIKVALPEFTQDQSDNPGEGDHRLPQLSVHAGILGQIAVKVQRDVAYALTSTASLSNEELDELDSALDDATLLISDQLYQLDCQLNQLLITSSRDPGWWSEILRFFYIEETNVNRVLRRIDDVKRICDKAHKNRLKISDQLATGVVSIDDLHKTLCSWEDQLNRYSTSEETNLKDLQGRLKDHHSPSWFWGYLSCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZK13</accession>
    <name>C7ZK13_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_86864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698937">
        <property type="protein sequence ID" value="EEU35646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041359.1">
        <property type="nucleotide sequence ID" value="XM_003041313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZK13"/>
    <dbReference type="GeneID" id="9675984"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86864"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86864"/>
    <dbReference type="eggNOG" id="ENOG502SIE8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004184_7_2_1"/>
    <dbReference type="InParanoid" id="C7ZK13"/>
    <dbReference type="OMA" id="THFIGRR"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF79">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="43"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="648" mass="73480" checksum="F5912950B1D3BC4C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZK98</accession>
    <name>C7ZK98_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_55529</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GG698938">
        <property type="protein sequence ID" value="EEU35522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041235.1">
        <property type="nucleotide sequence ID" value="XM_003041189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZK98"/>
    <dbReference type="STRING" id="660122.C7ZK98"/>
    <dbReference type="GeneID" id="9675955"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55529"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55529"/>
    <dbReference type="eggNOG" id="KOG1371">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_10_1"/>
    <dbReference type="InParanoid" id="C7ZK98"/>
    <dbReference type="OMA" id="CAPVNPY"/>
    <dbReference type="OrthoDB" id="9402762at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000418">
        <property type="entry name" value="UDP-glucose 4-epimerase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF3">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="5">
        <location>
            <begin position="65"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU35522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="437" mass="47624" checksum="F111C03427B5F556" modified="2009-10-13" version="1">MDSYFSPPGTETPTSDAEFPFPSRSQSFQSLNSLSQPGTPDTERDVLFSGPPSRASFALNSDEYVLVVGGLGYIGSHTVWELVKDGRNVVVVDNLSNAFMGVLDTLNDMADKHTSSLGLRRPDLHFYEADFRDDIKMGQILPLYSTPGGSKIKRVIHFAAYKSVSESIEKPLKYYDNNVGGLIRFCSMLSSFNIKYLVFSSSATVYGSLADQGGRLVEEACTHTTTEWSDASGQARTTLSGCTGLTNPYGRSKWICEAILADLAVADPEWTIVALRYFNPIGCDESGRLGEDPRVTPTNLMPVVLKVMLGEMDRLHVFGTDWDTRDGTAIRDFIHVSDLARGHLAALTVKEKQGFQVFNVGTGTGHSVYEVIDAVQAAFGKDVPMIKAGRRDGDVGVCVADPQRAMAELGWKPQKTLLDSCRDLCRFLQANGAGVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKJ0</accession>
    <name>C7ZKJ0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_86172</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698940">
        <property type="protein sequence ID" value="EEU35448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041161.1">
        <property type="nucleotide sequence ID" value="XM_003041115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKJ0"/>
    <dbReference type="GeneID" id="9675811"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86172"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86172"/>
    <dbReference type="eggNOG" id="ENOG502RXDV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007003_4_0_1"/>
    <dbReference type="InParanoid" id="C7ZKJ0"/>
    <dbReference type="OMA" id="CKNCARS"/>
    <dbReference type="OrthoDB" id="4161332at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="642"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU35448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="753" mass="82477" checksum="92028F93DF7DEBB8" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKP1</accession>
    <name>C7ZKP1_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_86221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698940">
        <property type="protein sequence ID" value="EEU35478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041191.1">
        <property type="nucleotide sequence ID" value="XM_003041145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKP1"/>
    <dbReference type="GeneID" id="9675721"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86221"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86221"/>
    <dbReference type="HOGENOM" id="CLU_918574_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZKP1"/>
    <dbReference type="OrthoDB" id="10500727at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="303" mass="34347" checksum="DC18F64269E2DFDC" modified="2009-10-13" version="1">MIPGGILPATRKHYWRRVLDRRPNGKRPETPSPPEPDPKRPRTALRDEAATLSGSQENLHDLDNIVQPRNLNPLDQPSCSTYSNGNPEAIRPHLPFHQRDGEDASATLGESISGHNVPSREPLLPQHMLPQPLAFFLSLRARESIARLNEARLSMMIERIQRGQVEGFVFDREELAWTWEGMQDDSQARWDGPVMEGKGVEVTERGQARWYLWSPQVNRGDWFGGRVVAEVVFRVAMDRVLSFVAIVICWLNMDSAFSMGPEAMMGLLQLEALRPNHQRMRMITSERADKGADTDGSQLRDPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZL96</accession>
    <name>C7ZL96_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_53291</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698944">
        <property type="protein sequence ID" value="EEU35194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040907.1">
        <property type="nucleotide sequence ID" value="XM_003040861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZL96"/>
    <dbReference type="GeneID" id="9675237"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_53291"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_53291"/>
    <dbReference type="eggNOG" id="ENOG502SY1T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057733_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZL96"/>
    <dbReference type="OMA" id="CSDTTVK"/>
    <dbReference type="OrthoDB" id="4158815at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="176"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="257"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU35194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="35004" checksum="B76317951EC5466D" modified="2009-10-13" version="1">MSDLKPATKIDPNVWYQLTEAAVDDYEGDFVSSLQPVAQDDDLHVWPAKGINAFWQFQPIGDKPGRYAIRCSKTTTQKQLSVCYRPDVKVENRRTHACLLDSDGTDAQHWDVASWGANDTYRLINVKNGTDYYLDCVPNGPVFLSPNHEGYQSRQHWLMTSVKDVDDAAYSTVFSEDSSSTSHPITTSTSASESTASESETSTSGTSEAASSSGDSSNNKGLSSGAIAGISIGATLAVVALALLAFFLWRRKKRNSQTPKIVGSPESNNEGSDLPMPVSPVPAYNSLQQREKLDSEPPSIQEMLHEQAPVELSADQRHEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLE0</accession>
    <name>C7ZLE0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_87362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698944">
        <property type="protein sequence ID" value="EEU35219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040932.1">
        <property type="nucleotide sequence ID" value="XM_003040886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLE0"/>
    <dbReference type="GeneID" id="9675221"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87362"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87362"/>
    <dbReference type="HOGENOM" id="CLU_1875986_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZLE0"/>
    <dbReference type="OMA" id="MRFNAVV"/>
    <dbReference type="OrthoDB" id="3354195at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988215" evidence="1">
        <location>
            <begin position="20"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="136" mass="14015" checksum="86F3345B9422DE00" modified="2009-10-13" version="1">MRFNPSALVLAVLAGTAIAGHSHIEARVPQANDPLSFLSGLSYAPITDLLNQVLGPPLRKIEDALNFTLTQKLTESLQGGAPLSVLVAVVEALGELLNGADIGAVDKNLAVNSNGYFDSLDSALGVVNIGQAVKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZM24</accession>
    <name>C7ZM24_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_39683</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698949">
        <property type="protein sequence ID" value="EEU34921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040634.1">
        <property type="nucleotide sequence ID" value="XM_003040588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZM24"/>
    <dbReference type="STRING" id="660122.C7ZM24"/>
    <dbReference type="GeneID" id="9679044"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_39683"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_39683"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064755_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZM24"/>
    <dbReference type="OrthoDB" id="5095988at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="239"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU34921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="339" mass="38488" checksum="43A57CED619A7A37" modified="2009-10-13" version="1">MECFGLPSHSMSYPFDSTSFSSASSSYGPFIPTSRVSTPHEFSALEPDASYTFSYRVDVSSQEGAGNVMLDAISTKPEQMPFPNGPPNKPTKQELIDFDYREISMAHKPSMDPLATSRPETFAISHGAVIDATSFVMTPTQVSSGFKDTSVHSPWSRTSSSPFLQSNDDIFDIDRQPEYPYYIYDSHCIRDADSLEQARPRQIVTEEIHKTAEIPSIQARSPGKRAIEPVPISAKPVWSSCDYPGCDRAFRRKEHLKRHKQSFHGEGPNRFLCEFCGKGDFNRRDNLNIHRKLHARRNSHNRRVKFVADAVTAIEQEKRSRRFRARTRQRDQWCISGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMT7</accession>
    <name>C7ZMT7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_17767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698958">
        <property type="protein sequence ID" value="EEU34675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040388.1">
        <property type="nucleotide sequence ID" value="XM_003040342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMT7"/>
    <dbReference type="FunCoup" id="C7ZMT7">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="GeneID" id="9678820"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_17767"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_17767"/>
    <dbReference type="eggNOG" id="ENOG502RXBQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030124_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZMT7"/>
    <dbReference type="OMA" id="RYKPEAN"/>
    <dbReference type="OrthoDB" id="2968323at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF13">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="298" mass="33259" checksum="D04A66C091E9991F" modified="2009-10-13" version="1" fragment="single">WRAEPDIEKIKSTLRSLWPSSTVQVAFFAQGAFNKLYHVIVEGPPPLMLRISLPVDPRYKTLSEVATIRWVNTVTTIPLPQVITYSSSLDSALGFEWILMTRLDGTSLSSAWTHIDFSTKTALVRQFASFTASLFRNQLSGIGNIYPPVLSTLTPTTGRIVSMPFFWGDRINLDIDRGPFRHSRDWIAGRLQLAESDCLAVLRKYPADAEIDSDAEDDKEDATRTASIIAKLQQLIDLVFPETTKGEETTVLSRTDLSRSNILVDDAGNLTGVVDWECVSALPMWKACSYPSFLEGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZN42</accession>
    <name>C7ZN42_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_88858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698962">
        <property type="protein sequence ID" value="EEU34556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040269.1">
        <property type="nucleotide sequence ID" value="XM_003040223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZN42"/>
    <dbReference type="GeneID" id="9678703"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88858"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88858"/>
    <dbReference type="HOGENOM" id="CLU_1337832_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZN42"/>
    <dbReference type="OrthoDB" id="10360254at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU34556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="205" mass="22987" checksum="70498BCE8F7968B3" modified="2009-10-13" version="1">MADTLAQKFDAATAAAIQKASVLEESKPSRLSDDDTKVTKTAVAGIMGCKGDHRVLSEIEFRVLVFYASRLQMTDRVNILATQASLIVQRRKADQQLLTGMDKEFVNGTTSITGTKAAKIASVMRANPGYFPEPEEPDNWFRLPQLSNGPSLPSYQDARKMAPLKTAQEAEAIYTQRLRHHEYPLQQLINNDGMMWRLKMEWGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNJ8</accession>
    <name>C7ZNJ8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_44457</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698969">
        <property type="protein sequence ID" value="EEU34418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040131.1">
        <property type="nucleotide sequence ID" value="XM_003040085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNJ8"/>
    <dbReference type="STRING" id="660122.C7ZNJ8"/>
    <dbReference type="GeneID" id="9677956"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_44457"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_44457"/>
    <dbReference type="eggNOG" id="KOG4711">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001788_0_1_1"/>
    <dbReference type="InParanoid" id="C7ZNJ8"/>
    <dbReference type="OMA" id="FYSCMHT"/>
    <dbReference type="OrthoDB" id="2274698at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF4">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="542"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="571"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="610"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="651"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="6">
        <location>
            <begin position="129"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="7">
        <location>
            <begin position="564"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU34418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="841" mass="92909" checksum="B4268F91D37D2368" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZP47</accession>
    <name>C7ZP47_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_96663</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039998.1">
        <property type="nucleotide sequence ID" value="XM_003039952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZP47"/>
    <dbReference type="STRING" id="660122.C7ZP47"/>
    <dbReference type="GeneID" id="9677933"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_96663"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_96663"/>
    <dbReference type="eggNOG" id="ENOG502S58E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050545_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZP47"/>
    <dbReference type="OMA" id="HNRTEME"/>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21245">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="16"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="155"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="250"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU34285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="291" mass="32397" checksum="E60CA7F70C8EF9E0" modified="2009-10-13" version="1">MMFPTHTSQTRALKADYLTSGNLPYEAKPYDVEEVLSSNGFGNLDKIHISIDPVSARNPGYCFVDFPDRETAQNALESLSATIRGRSIKVGPCEPKKPRRNFGDEPATSRRWGDWRTKSEEGGVPIGQLNNKGEEKGPYWAMDHFDDAIRSEEVRRLYVGGLGKMIDQAQHQREITEIFTGFNPTAIGKRITPHESTRAQPGRHHYCFVDFETKEEALAAADALNGSTTTGGPLKVSLAEKIPAKLVARHPDRRNGRRVYDKAYARPGNTGSENATESGSAFSSNNWRRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZP50</accession>
    <name>C7ZP50_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_85596</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039797.1">
        <property type="nucleotide sequence ID" value="XM_003039751.1"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZP50"/>
    <dbReference type="GeneID" id="9677935"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85596"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85596"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_257882_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZP50"/>
    <dbReference type="OMA" id="WAGAYET"/>
    <dbReference type="OrthoDB" id="5050650at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="160"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1161"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU34084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1348" mass="151260" checksum="11EB54CF33D1C987" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQ14</accession>
    <name>C7ZQ14_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PD-(D/E)XK nuclease-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_88819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698978">
        <property type="protein sequence ID" value="EEU33899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039612.1">
        <property type="nucleotide sequence ID" value="XM_003039566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQ14"/>
    <dbReference type="STRING" id="660122.C7ZQ14"/>
    <dbReference type="GeneID" id="9667132"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88819"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88819"/>
    <dbReference type="eggNOG" id="ENOG502SSY4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027219_0_2_1"/>
    <dbReference type="InParanoid" id="C7ZQ14"/>
    <dbReference type="OrthoDB" id="4161186at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046797">
        <property type="entry name" value="PDDEXK_12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20516">
        <property type="entry name" value="PDDEXK_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PD-(D/E)XK nuclease-like" evidence="2">
        <location>
            <begin position="124"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU33899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="383" mass="43721" checksum="21364E52EBF3CA95" modified="2009-10-13" version="1">MSVSERSGQSAKRPRIESSEDEDEDDEYLAEVDKTPRPQSNILRQHSLPSESQSQTSGRSSPSKQMNTLELSGFKWNQQLSLANPDIPDELFEFLTEIVNCNNGIGIISRDEKAQIAQRAQSNRSYRLFQDVMYADPTVRDAIGLTPPIDDVEWVVAEARECQEFSHPEASWNESVHFPLLHKAVYGPRRKRQRVGVGNCTTAKLIREYLPKNTLAKRVDYSFFIDPGADTLPTSKSPAEAVADLRKVMPCQVINHTAYRPFRDRPMVVTVETKKRYGSQEGAELQTGTWHAAHWEFLARRIEKTGGTLEGLPFLPGILIQGHDWSFVATTREESKTVVWLEQKFGYTNDTIGVYKAIWGVQRLARWVDDVYWPWYKKNVLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQC1</accession>
    <name>C7ZQC1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_89138</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698987">
        <property type="protein sequence ID" value="EEU33794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039507.1">
        <property type="nucleotide sequence ID" value="XM_003039461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQC1"/>
    <dbReference type="GeneID" id="9667021"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89138"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89138"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="InParanoid" id="C7ZQC1"/>
    <dbReference type="OMA" id="INHPAYR"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000217">
        <property type="entry name" value="MFS lactose permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF13">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="51"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU33794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="542" mass="59404" checksum="9174B7E0A05B98E5" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQL7</accession>
    <name>C7ZQL7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_98371</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG699001">
        <property type="protein sequence ID" value="EEU33690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039403.1">
        <property type="nucleotide sequence ID" value="XM_003039357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQL7"/>
    <dbReference type="GeneID" id="9666922"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_98371"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98371"/>
    <dbReference type="eggNOG" id="ENOG502QS4K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036005_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZQL7"/>
    <dbReference type="OMA" id="TAYYAQP"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF10">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="8">
        <location>
            <begin position="23"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU33690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="327" mass="36502" checksum="548A6C651CF010CC" modified="2009-10-13" version="1">MILSQLPSMENSLGYSPTTFESFDVTPVIGREFVGVDLSNLLRAPNSDELIRDLAITISRRGVVFFRKQDNLTDDLQKELVQRLGEQSGKPATTRRVTTPARTTRSASFRPNRRRSCFLAAMPASASELSAKPIPSDYALLRLTQLPETGGDTLWASGYELYDRISPTLQRFLDTLTAKYAQPQFNQAAKENNFSIYSAQRGAPENVGEVLEAVHPVVRTNPVTGWKSIFAVGQHVERIHGLSETENRHFLDWFIDLINANDVAIWDNGSVYHAATPDYMFEQGLGERYGVRAVSLGEKPYFDPQSTGRRESLEKETQEAAVPEVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQT5</accession>
    <name>C7ZQT5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_89307</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="GG699010">
        <property type="protein sequence ID" value="EEU33625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039338.1">
        <property type="nucleotide sequence ID" value="XM_003039292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQT5"/>
    <dbReference type="STRING" id="660122.C7ZQT5"/>
    <dbReference type="GeneID" id="9666859"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89307"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89307"/>
    <dbReference type="eggNOG" id="KOG1535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_2_1_1"/>
    <dbReference type="InParanoid" id="C7ZQT5"/>
    <dbReference type="OMA" id="RHMLFKV"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="80"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU33625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="286" mass="31556" checksum="93CB2CE5C0EA86C8" modified="2009-10-13" version="1">MPVSSWINFRSCSMKVPFQRLVRFRDPDGNILYGEAPPGNSLCGQRVPVYVGNHPWDLRESGHHQVITEVLCPLAQTPLVYGVGLNYEKHIVECGYPRPEYPSNFVKPPDALNGPYSDVHVNKNHPDIDYEGELVFIVGRDACAIETAHAEDYILGYTVGNDVTSRHWQRVPGIGNSFGKSADGFAPIGPVIVTTGVVESEGLELVTMVNSEERQRSRLDDLRFKAGDILAHLTKFNTLRAGTVVMTGTPAGVGAFMNPPSWLRDGDVVEVYISDIGTIRNRFVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZR14</accession>
    <name>C7ZR14_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_89383</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699024">
        <property type="protein sequence ID" value="EEU33539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039252.1">
        <property type="nucleotide sequence ID" value="XM_003039206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZR14"/>
    <dbReference type="STRING" id="660122.C7ZR14"/>
    <dbReference type="GeneID" id="9666778"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89383"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89383"/>
    <dbReference type="eggNOG" id="ENOG502RHJM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038732_9_0_1"/>
    <dbReference type="InParanoid" id="C7ZR14"/>
    <dbReference type="OMA" id="PQGRMTT"/>
    <dbReference type="OrthoDB" id="2349068at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF34">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU33539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="353" mass="37499" checksum="B51CF70A181DAC50" modified="2009-10-13" version="1">MASSLTLQQMFPWTQAPLICSAPMRGVSGAALAVAVSAGGGLGFIAGADDVSTLEGKFEAAKRLVAEQKAQSESPEENPLLLHTGSTLPVGVGFLNWGADIEVALPLIVKYRPVAVWLFAPRDGAADQHPWVRRIRDQTDGDVSIWVMVGDIGDATDAMKHLQPDVLVLQGADGGGHGLATSASILALVPEMVDKLVARHLDDPLRAPIPKIVAAGGLVDGRGIAAALMLGAEGVAMGTRFLASFESEITKEYQKAVVDTQDGGRFTIRSPIFDKARGTIFWPPKYAARGVINRTYSDFAQGKVTEADSFSQYQQDLENAQVKYGVNGRINTLVSTAVGLVKEVLPAAEIVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZR57</accession>
    <name>C7ZR57_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_12611</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG699035">
        <property type="protein sequence ID" value="EEU33497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039210.1">
        <property type="nucleotide sequence ID" value="XM_003039164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZR57"/>
    <dbReference type="GeneID" id="9666732"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_12611"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_12611"/>
    <dbReference type="eggNOG" id="ENOG502RZ2S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006926_1_1_1"/>
    <dbReference type="InParanoid" id="C7ZR57"/>
    <dbReference type="OMA" id="WTVYIFD"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="167"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU33497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="453" mass="50975" checksum="87B1C985C308F7F9" modified="2009-10-13" version="1" fragment="single">YVGDAACEAFNTRVRRHLRNDDSIAPPKHDRYFKTNTLRKLVDRDLDLPDQGYAMLLIETAERFVGSEYHMFLRRTFLHQFDEVYKPGTPKDPVWLCGLFAILALGELYSNIPVCAHRSQADIPGTGFFLRALDLFEDLYEEPTVSYIETVLLLSYYSHALNRRNSAYIFTGLAMRLSMALGLHRELPAQLASPFEHEHRRRVWWTVYAFDRLCSLKLGHPVMIKDEDISVNLPSHNNLTSDDLEDLPDPKQILSSIAMARIAGSILQDLYQPRSRFAILPNVQKILAQLKDFIQSLPDELSLAKIASTACPGRALASLHVHCNHCIVLTTRPVFFQHFQSQATLPHVRASHGPCSAVMPALADACVSAATTCYKLLRRLWVNGQIVTLGGFDSQYLFSAATILAMSHSLKPTNSSRTLLEGSSSMLRIMGTSGNIPARGYYEQLAELKHDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHI4</accession>
    <name>C7YHI4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Cytidine deaminase</fullName>
            <ecNumber evidence="4 13">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 13">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NECHADRAFT_74982</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2'-deoxycytidine + H2O + H(+) = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 13">
            <text>cytidine + H2O + H(+) = uridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="4 13"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054358.1">
        <property type="nucleotide sequence ID" value="XM_003054312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YHI4"/>
    <dbReference type="FunCoup" id="C7YHI4">
        <property type="interactions" value="170"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YHI4"/>
    <dbReference type="GeneID" id="9664589"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74982"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74982"/>
    <dbReference type="eggNOG" id="KOG0833">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097262_2_2_1"/>
    <dbReference type="InParanoid" id="C7YHI4"/>
    <dbReference type="OMA" id="LTHFTCV"/>
    <dbReference type="OrthoDB" id="414540at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055086">
        <property type="term" value="P:nucleobase-containing small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072527">
        <property type="term" value="P:pyrimidine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01283">
        <property type="entry name" value="cytidine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000069">
        <property type="entry name" value="Cytidine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050202">
        <property type="entry name" value="Cyt/Deoxycyt_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004064">
        <property type="entry name" value="PRK05578.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644:SF2">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="27"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="68"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU48645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="165" mass="17601" checksum="62C571DB8AD4C59F" modified="2009-10-13" version="1">METPETISKGDAARTAEICEQHGITPNEFSELRQRATAAKATAYCPYSRFRVGATVLSGEGQFIDGANVENASYPVGTCAERVALGTAVTGGHRGFRAVAVATDIAPPASPCGMCRQFIREFCTLETPIIMFDKNEDFVVVKLGQLLPMSFGPDQLPPPEALSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHJ1</accession>
    <name>C7YHJ1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SWI5-dependent HO expression protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_74989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054362.1">
        <property type="nucleotide sequence ID" value="XM_003054316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YHJ1"/>
    <dbReference type="STRING" id="660122.C7YHJ1"/>
    <dbReference type="GeneID" id="9664593"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74989"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74989"/>
    <dbReference type="eggNOG" id="ENOG502S77X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044609_1_0_1"/>
    <dbReference type="InParanoid" id="C7YHJ1"/>
    <dbReference type="OMA" id="NMHQHNG"/>
    <dbReference type="OrthoDB" id="3918393at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="183"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="303"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU48649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="46420" checksum="A0E531CE113697BF" modified="2009-10-13" version="1">MRNRLHKKDFSIHKDAVNAAASLAARFTELHAPAEKEKTLTPASTGSINSMKGRSPATYKPAVARSSTIRSVPSFEGSESSPDSKHSAFSSSVNSTASAMSNNPETNHHAQTPIKAKADPNNTSTTPSRWSTGAPRVVEPTPEPEHSTMSEGPEHTDGQWDSTIGKAGLGKTGRVINKLVSDNESLKRDIQIERLKADEAKQAAKLVEDKMERVVSDYESRLLEANVTKTLLARKERQVESLSATVDLEKKKTASALERERNWKDEMEKTRKETTVQVEEATNYAQLMEGRYNAISSHWQNQGDEVKRAVSKMKTEIEQLNEERRKDDDKIQTLKDLCDQQDNNIKQLRHEKEEIARMFEEYKKAQEDALKDIKTNARKREDEQERLLEQSREALAKLKWALNVKENVKGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHJ9</accession>
    <name>C7YHJ9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_74996</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054367.1">
        <property type="nucleotide sequence ID" value="XM_003054321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YHJ9"/>
    <dbReference type="GeneID" id="9674509"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74996"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74996"/>
    <dbReference type="eggNOG" id="ENOG502TE6H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1261820_0_0_1"/>
    <dbReference type="InParanoid" id="C7YHJ9"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="27"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU48654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="219" mass="23780" checksum="E1C286DFF8134062" modified="2009-10-13" version="1">MAADRQIIHETPLFSCDKPRRLWGAHQSIALAWTTLNGQTRDELQAAFAGLLGLSTRAGLSKTQRQQLEGFVKEYASADMGGRRVHIHRIASHINHACGRCANAKASIDSADPNSISVTLLRPVSAGEQILIKYKKPNAHCFNNPKRLPHKNSSNPQLTSNNLLNTGMPHKVKARMPHKTKARMPHKSNNNPGRGASASDREPAVGGPVGLGEVANWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHK3</accession>
    <name>C7YHK3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_74999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053638.1">
        <property type="nucleotide sequence ID" value="XM_003053592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YHK3"/>
    <dbReference type="STRING" id="660122.C7YHK3"/>
    <dbReference type="GeneID" id="9674586"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74999"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74999"/>
    <dbReference type="eggNOG" id="KOG4313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048013_0_0_1"/>
    <dbReference type="InParanoid" id="C7YHK3"/>
    <dbReference type="OMA" id="PVGYMLP"/>
    <dbReference type="OrthoDB" id="10261522at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03676">
        <property type="entry name" value="NUDIX_Tnr3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="174"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU47925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="390" mass="43706" checksum="1C1E090EC70E00BE" modified="2009-10-13" version="1">MASTRLAKPSGEATQSSCLNHSAAELIYPGTPSHSLDMTSLYGVVQQGNKIDAVDLEKVWAFYIQGIDEVVGYMRDDVQRDMIWDENFTMNQDTRTILLNPKIQSGENIATACCRVFSNLCLLNRGRFNNCIDGWLAKDVPRREFQPLHVADSTRQDLTIPLPIRGLFGVVTVGVHLNVYTVKQVDGRESVDRIWVSHRAKGVNVSYSGMLDQVVAGGMDPTDRVSGVLSPCVTLKREAREEAGLHIDLNTREVLMGQEDSTRRLVGSVEQAPAITFYDCKDRNAGLMNEGHLEPGVRFVYDLRVDTTFQPHAEERGIERFEALSVDEVKKSLHSLEWKPNCGLVMVDFMVRKGLVSEADDTRLGDIMTGLQRPLPFKFAQDKFRVLDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIS4</accession>
    <name>C7YIS4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-homologous end-joining factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_75426</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the XRCC4-XLF family. XLF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054569.1">
        <property type="nucleotide sequence ID" value="XM_003054523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIS4"/>
    <dbReference type="STRING" id="660122.C7YIS4"/>
    <dbReference type="GeneID" id="9664691"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75426"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75426"/>
    <dbReference type="eggNOG" id="ENOG502SCQK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022898_1_0_1"/>
    <dbReference type="InParanoid" id="C7YIS4"/>
    <dbReference type="OMA" id="IKGVAPF"/>
    <dbReference type="OrthoDB" id="2155935at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045027">
        <property type="term" value="F:DNA end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.210.10">
        <property type="entry name" value="DNA double-strand break repair and VJ recombination XRCC4, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052287">
        <property type="entry name" value="NHEJ_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053829">
        <property type="entry name" value="XLF-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015381">
        <property type="entry name" value="XLF-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038051">
        <property type="entry name" value="XRCC4-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32235">
        <property type="entry name" value="NON-HOMOLOGOUS END-JOINING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32235:SF1">
        <property type="entry name" value="NON-HOMOLOGOUS END-JOINING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09302">
        <property type="entry name" value="XLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21928">
        <property type="entry name" value="XLF_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XLF-like N-terminal" evidence="9">
        <location>
            <begin position="2"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="XLF-like coiled-coil region" evidence="10">
        <location>
            <begin position="96"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="231"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="441"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU48856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="503" mass="53921" checksum="A7186AA2D9968253" modified="2009-10-13" version="1">MANVWTESLDRKSICIRGWSENTTIDPSDTPDNMAKFLDSLNTALDSTQPGHDETHLRLEPASKSDAGEGGLTLKITCELLGLQPLKWPMHLKKLPSSAIAADLVLPLIQAHLTRNLEVESLIRTLGHKDVVITKLLDKLEAVGTGLEHVFNGLSGKKRISRAAAADKIPGLAPFDRHRWKSGLAYTDDGPSNTESLIEDVLGGGGLQFEPTIEVAESPLLDDWWHQFSGASSVGRPSQKAIPAKETTPPPQVSGVGDDDDDDFQVQSTPPHLTAARKSMASRGKGKPVLDDASTEGDPESPASAKDVPVPPETRKETRPTRRLGALGRKKQSTPPRSPSPKIPSPAKKAPSPNVDDSETASEAEDDGATASLPDDDPPPAPSPSPPPKPVAKKSGLGRIGGAKAKQPVKETSPPTEPEVTEIARPATQNPPKRLGVIGKKKGDAKEPSSAADESRGRARSTKEEAPKPRETSQERADRRREELKRELEKKAAAGPAKKKRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJE9</accession>
    <name>C7YJE9_FUSV7</name>
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        <recommendedName>
            <fullName evidence="2">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_75654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EEU48964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054677.1">
        <property type="nucleotide sequence ID" value="XM_003054631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJE9"/>
    <dbReference type="STRING" id="660122.C7YJE9"/>
    <dbReference type="GeneID" id="9663833"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75654"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75654"/>
    <dbReference type="eggNOG" id="ENOG502SW8P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_466985_0_0_1"/>
    <dbReference type="InParanoid" id="C7YJE9"/>
    <dbReference type="OMA" id="GPSHENT"/>
    <dbReference type="OrthoDB" id="5308957at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF3">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="57"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU48964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="584" mass="65489" checksum="0557794B27880401" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7YK31</accession>
    <name>C7YK31_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_74465</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053384.1">
        <property type="nucleotide sequence ID" value="XM_003053338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YK31"/>
    <dbReference type="STRING" id="660122.C7YK31"/>
    <dbReference type="GeneID" id="9676716"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74465"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74465"/>
    <dbReference type="eggNOG" id="KOG2590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005100_1_0_1"/>
    <dbReference type="InParanoid" id="C7YK31"/>
    <dbReference type="OMA" id="WPTPQVA"/>
    <dbReference type="OrthoDB" id="340227at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07323">
        <property type="entry name" value="LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF132">
        <property type="entry name" value="LA-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="563"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="24"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="742"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="298"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="443"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="466"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="757"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU47671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="793" mass="85474" checksum="69844637CF264CC4" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNA3</accession>
    <name>C7YNA3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_35846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053300.1">
        <property type="nucleotide sequence ID" value="XM_003053254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNA3"/>
    <dbReference type="STRING" id="660122.C7YNA3"/>
    <dbReference type="GeneID" id="9671335"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_35846"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_35846"/>
    <dbReference type="eggNOG" id="ENOG502S80R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065010_0_1_1"/>
    <dbReference type="InParanoid" id="C7YNA3"/>
    <dbReference type="OMA" id="RFWFYMP"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.320">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010323">
        <property type="entry name" value="DUF924"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06041">
        <property type="entry name" value="DUF924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU47587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="250" mass="29071" checksum="DC54E8CF9C8DAAE3" modified="2009-10-13" version="1">MAYGSQTVVELSQMLDNSLLDRVRRFWFRHITDDHHLIVPDKEKALVWFSQDDEFDQECISTFGPVLDFLSSETNRIGVDYILHATNPTSALDWMSLIILLDQIPRNCYRGEMAAVAYRFFDPIVLGLAFQAIATGIPEHPEVRYRHAYRFWFYLPLQHCENAKILQGVVREHDLMFDDSRQLMGVNVCVSLQSPEVLHCRDVLIKRRESLGIWEATLRGIVRDHMATLEEHGRYPHRDRALGRNVNCNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNB4</accession>
    <name>C7YNB4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_22566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053305.1">
        <property type="nucleotide sequence ID" value="XM_003053259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNB4"/>
    <dbReference type="STRING" id="660122.C7YNB4"/>
    <dbReference type="GeneID" id="9664371"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_22566"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_22566"/>
    <dbReference type="eggNOG" id="ENOG502TBH9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016575_2_0_1"/>
    <dbReference type="InParanoid" id="C7YNB4"/>
    <dbReference type="OMA" id="WEWHALN"/>
    <dbReference type="OrthoDB" id="5123901at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU47592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="467" mass="52949" checksum="2836C86F7927F872" modified="2009-10-13" version="1" fragment="single">HAGCAALAERLGLTPAEYLPALAYSYEPSKSDERRRLELVRFRLQQALKRNIGRFPTEVWDFVAKDLVCEFATVAIPVVEPKTVFTIDALEAVWATYVEIDGVEYIKSVSNEQKPGGRLLWDKPKSPTGHVYIGEDHLGISEITNHPEVTQSAQSKQVSTWWRTVTLKHSSKIDFKTDGVKLRSFSAATLLRDVKWPYPMTPDEIKGMYLYYTALDREAKMIPVDINAPDTIGYSVGWHYGCVYFHAHKRGESLDFYHELDARQLDENEAAAKNQDERHEPHAVKVDRMARMAEESGIEWRYHPLNAGEAIEQVWIRQPQKLPDDDDDDDDSPFGPRYLWCDASHDVAIGLVTNQSRVLVSGIPCEFPQDRFPWRCIAKSSTASPMRIFFSYSLDGINLFAAPKSGVPKGEPVHQGLYEEEPDNFCLFGYDFHTSASLENVAQVVLCKGTEQGKPRINGLLFRYKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPK5</accession>
    <name>C7YPK5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C4-dicarboxylate transporter/malic acid transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_78786</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052025.1">
        <property type="nucleotide sequence ID" value="XM_003051979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YPK5"/>
    <dbReference type="GeneID" id="9668729"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78786"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78786"/>
    <dbReference type="eggNOG" id="ENOG502R08Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030057_2_1_1"/>
    <dbReference type="InParanoid" id="C7YPK5"/>
    <dbReference type="OMA" id="FYHYPYT"/>
    <dbReference type="OrthoDB" id="2901184at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015140">
        <property type="term" value="F:malate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09317">
        <property type="entry name" value="TDT_Mae1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030185">
        <property type="entry name" value="Mae1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162:SF3">
        <property type="entry name" value="TRANSPORTER_MALIC ACID TRANSPORT PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988189" description="C4-dicarboxylate transporter/malic acid transport protein" evidence="6">
        <location>
            <begin position="29"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU46312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="54025" checksum="BB460DF9D5D0EC64" modified="2009-10-13" version="1">MPLANFGTLVLHHLVFVAHLAYFHIAFAHMEPSALVVLYCVSKLLARRADDIDGPPPEWPPPVIQCLNHVMAIAEKSPVTPKVGIRDRIACHRWTYFTMTMSTGGVANILHSRKPTPNVKWDTPWIRGIGLFFFILNLILFVTNLILLSIRFHIRPGSFTHSFTDQVESLFIPASVVSIAVILINTCQYGIPNTGIWLLRTMELMFWIYAALSVGVSALLYLILWSTLVFPVHTMTPTWVFPAYPLLLNAPFAANLIAAAHASGHALSTNTTAMALGAAAIQGTGCLIAFMISSAFIYRLMTQKLPRDTQRPGIFMSIGPYGFTAAGIAQLGNQAESLLPPDFLDTPQVAPIIKVVCILVSLWLWGLAMWFFLVCVGALWKYVRAGSSMPFQISWWSFVFPNTALVTATSVMGNIFHSDGLHIFACVMTIAIVIVWAVVFGRMVWCLKEKRLLWPKNETLRVIPSNAINHVYLVFTAAALLFLQAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPN4</accession>
    <name>C7YPN4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="2 12">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NECHADRAFT_78814</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 12">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="2 12"/>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051592.1">
        <property type="nucleotide sequence ID" value="XM_003051546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YPN4"/>
    <dbReference type="FunCoup" id="C7YPN4">
        <property type="interactions" value="1260"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YPN4"/>
    <dbReference type="GeneID" id="9673266"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78814"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78814"/>
    <dbReference type="eggNOG" id="KOG1112">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000404_1_2_1"/>
    <dbReference type="InParanoid" id="C7YPN4"/>
    <dbReference type="OMA" id="IELPQHM"/>
    <dbReference type="OrthoDB" id="3000483at2759"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051063">
        <property type="term" value="F:CDP reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046704">
        <property type="term" value="P:CDP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006240">
        <property type="term" value="P:dCDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01679">
        <property type="entry name" value="RNR_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.70.20:FF:000001">
        <property type="entry name" value="Ribonucleoside-diphosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573:SF6">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="R1 subunit of ribonucleotide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="14">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="798"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="841"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU45879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="893" mass="100206" checksum="C91EDA3EEB85D0D2" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPP4</accession>
    <name>C7YPP4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 20">Glutathione reductase</fullName>
            <ecNumber evidence="4 20">1.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">NECHADRAFT_92562</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 20">Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 20">
            <text>2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="17">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="4 20"/>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051599.1">
        <property type="nucleotide sequence ID" value="XM_003051553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YPP4"/>
    <dbReference type="FunCoup" id="C7YPP4">
        <property type="interactions" value="1132"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YPP4"/>
    <dbReference type="GeneID" id="9673269"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_92562"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_92562"/>
    <dbReference type="eggNOG" id="KOG0405">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_2_2_1"/>
    <dbReference type="InParanoid" id="C7YPP4"/>
    <dbReference type="OMA" id="MSKHYDY"/>
    <dbReference type="OrthoDB" id="5956163at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000003">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000141">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000671">
        <property type="entry name" value="Thioredoxin reductase 2, tandem duplicate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006322">
        <property type="entry name" value="Glutathione_Rdtase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01421">
        <property type="entry name" value="gluta_reduc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004776">
        <property type="entry name" value="PRK06116.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF2">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 20" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 17 19" id="KW-0274">FAD</keyword>
    <keyword evidence="7 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-0520">NAD</keyword>
    <keyword evidence="9 20" id="KW-0521">NADP</keyword>
    <keyword evidence="17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13 19" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="22">
        <location>
            <begin position="9"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="21">
        <location>
            <begin position="356"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="184"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="46"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU365016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EEU45886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="469" mass="50685" checksum="2A38BA2A24AD6891" modified="2009-10-13" version="1">MAPITKETDYLVIGGGSGGLASARMASNKFGIKATIVESKRLGGTCVNVGCVPKKVTYNAAALAEAIHDSKSYGFSVEETAPFDWSTFKTKRDAYVKRLNGIYERNLNNDKVDYVHGWARLVSKNQAEVTLDDQSKVLINAKKILVAVGGKPTPPPSIPGAEHGINSDGFFEIATQPKKVAIVGAGYIAVEFAGMFNALGTETHLFIRHNTFLRSFDPMIQEAVTNEYERLGVKLHRSSQATKVEKDANGKLTVTYKDDAGNETVLSDVDHLIWAIGRTPETHGIGLEEAGVKLGEKGHILVDEYQNTAVDNIYALGDVTGEVELTPVAIAAGRRLAHRLFGGPEFSNLKLDYKNVPSVVFSHPEVGSIGLTEPQAIEKYGKDNIKVYKTGFTAMYYAMMDPEQKGPTNYKLIVTGPEEKVVGLHIMGIGSGEMLQGFGVAVKMGATKADFDSCVAIHPTSAEELVTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQ65</accession>
    <name>C7YQ65_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prefoldin subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_102554</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052132.1">
        <property type="nucleotide sequence ID" value="XM_003052086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQ65"/>
    <dbReference type="FunCoup" id="C7YQ65">
        <property type="interactions" value="770"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YQ65"/>
    <dbReference type="GeneID" id="9673435"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102554"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102554"/>
    <dbReference type="eggNOG" id="KOG4098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113004_1_0_1"/>
    <dbReference type="InParanoid" id="C7YQ65"/>
    <dbReference type="OMA" id="CFKMIGG"/>
    <dbReference type="OrthoDB" id="29646at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23163">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000002">
        <property type="entry name" value="Prefoldin subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027235">
        <property type="entry name" value="PFD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13303">
        <property type="entry name" value="PREFOLDIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU46419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="13463" checksum="D898562EFD2C9FF0" modified="2009-10-13" version="1">MSSAQVPAKKQQDLQATYSNYKNTLQQIAQKIGDIEQEAEEHKLVLETLEPLSGDRKCFRLINGVLVERTVKDVVPALKTNQEGLRKVLDDLVKQYKTKQDDLEKWKKKNNVQVVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7YR73</accession>
    <name>C7YR73_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_41605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051117.1">
        <property type="nucleotide sequence ID" value="XM_003051071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YR73"/>
    <dbReference type="GeneID" id="9665762"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_41605"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_41605"/>
    <dbReference type="eggNOG" id="ENOG502S5DH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084254_0_0_1"/>
    <dbReference type="InParanoid" id="C7YR73"/>
    <dbReference type="OMA" id="GHWLDDD"/>
    <dbReference type="OrthoDB" id="4510061at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU45404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="166" mass="18944" checksum="5A6D82AAAE82226E" modified="2009-10-13" version="1" fragment="single">EVLSDFRTLQYYIAAAPVDPEDTGDYYTEGWAALRQCSLDGQHILECAADTSVPNPPGGEDEQMKAELKQVLLDAYARRHEGQKIYLRQAAAQRWVEYRRQVLQSGSPSRNQSQLRACDRQLRTELAAITDEVIYAELKASDEGMGRWTAEDPSLRSVLRWLRARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRR0</accession>
    <name>C7YRR0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_40860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051217.1">
        <property type="nucleotide sequence ID" value="XM_003051171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YRR0"/>
    <dbReference type="GeneID" id="9665999"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_40860"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_40860"/>
    <dbReference type="eggNOG" id="ENOG502S60G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024592_0_0_1"/>
    <dbReference type="InParanoid" id="C7YRR0"/>
    <dbReference type="OMA" id="WKRHVSA"/>
    <dbReference type="OrthoDB" id="5388486at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039970">
        <property type="entry name" value="TF_Grauzone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23225:SF2">
        <property type="entry name" value="AT09679P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23225">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU45504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="485" mass="54182" checksum="9E29AB18EBAE323F" modified="2009-10-13" version="1">MQRYLQEQQPPLWFESQPCMPNSSYGYSSIVSSIAPGAQFRHDSPLSYQQSLATSDNDPYVDSTQGPSTPPNNVISSPHIAPQDSHSPRFMLTGLTDPGAGSDSSTSTPFYHDHHDHDPNPNLFASLNNPTYGVNNKAQTFVAYPDLQDADTEDAQQADDGSSSDLSSPTNRDDDDDEDYKPTRRAKSSRAPKSTPRRGRPRRSSSGTNASKTKISKPRPSSRATTARRLVSSTAVNTKVCPHCSNGFTDQATLQKHINSLHKRPFTCVFHFAGCDKVFANKNEWKRHVWAQHLNLHYWLCTNGACGHASTPEGGVYSKEPTHGRIFRRKDLFTQHIRRMHAPAHIVKAEKDKNLPSDWVAQEKMMQNRAVRQRCELPLFMRCPAQNCRLEFNNGSKTWDNRMEHVAIHLERAASNEESAVLFGGVNDVELTEWASSPSVNVIELTTGGWKTCQPLKATRVELCEAPNIDTILDEDAEGEECTYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRS8</accession>
    <name>C7YRS8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_40488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050839.1">
        <property type="nucleotide sequence ID" value="XM_003050793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YRS8"/>
    <dbReference type="STRING" id="660122.C7YRS8"/>
    <dbReference type="GeneID" id="9667998"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_40488"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_40488"/>
    <dbReference type="eggNOG" id="ENOG502S039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039745_0_0_1"/>
    <dbReference type="InParanoid" id="C7YRS8"/>
    <dbReference type="OMA" id="IPYTQCL"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058268">
        <property type="entry name" value="DUF7962"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25907">
        <property type="entry name" value="DUF7962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="13"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7962" evidence="2">
        <location>
            <begin position="112"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU45126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="333" mass="36909" checksum="97F3B36F159B55EF" modified="2009-10-13" version="1">MANPRVIVYHYSYSPFARRLIWYLTLRGIPYSQCIQPPLMPRPDVSRLGISYRRIPILAVGRDVYLDTRLQMRKLEAMFPKLPRLGATSPDQIAVERLLSTLTNDTDILATALPLLPQDLPLLKDPAYYRDRGDFLGTELNGSGMDAKKPEALVELASDIGFLENALLADGRDWISGTEKPSLADIEAIWPFHWITGIQGALPEDRFSPSVYPRVYAWIRRFQSAVSAAKKRVGAPVTLSGEEAASEIRAGSFCEPEKDVEASDAVVLAQSLRKGVAVMVWPTDTGSSGRDEGTLVSIDADEVVYETGGVEGFVRVHAPRHRFRVEGVKEAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7YU03</accession>
    <name>C7YU03_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP/GTP exchange factor Sec2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_84757</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050429.1">
        <property type="nucleotide sequence ID" value="XM_003050383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YU03"/>
    <dbReference type="STRING" id="660122.C7YU03"/>
    <dbReference type="GeneID" id="9674828"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84757"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84757"/>
    <dbReference type="eggNOG" id="ENOG502S1Y5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055310_0_0_1"/>
    <dbReference type="InParanoid" id="C7YU03"/>
    <dbReference type="OMA" id="CADYEDQ"/>
    <dbReference type="OrthoDB" id="5560525at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF4">
        <property type="entry name" value="GDP_GTP EXCHANGE FACTOR SEC2 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06428">
        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDP/GTP exchange factor Sec2 N-terminal" evidence="4">
        <location>
            <begin position="151"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="108"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="242"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="27"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU44716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="298" mass="33394" checksum="F33C1D14A23F0813" modified="2009-10-13" version="1">MVMTMAAPPIASDDSPCCPGCGYALPLDHTQVQLLEAQARIVDLENQVRLLNEKASAAVDRWADYEDELTRLRSQLASSPTQKQLPATPTNTRMSFLQSGTSRLSALLSPRKSHPDLGSIETNPSRPPPNQRSASSGSQPQLQPPPSPSAEDLLEALSREQNLRKEAEGKVAATSQEVEELSAALFEQANEMVAEERRARAKLEQRVDELERRDMEKRRRLDKLEGAMNRIERVRLLLAEAEQDVESSKQTVKEIEDLERQQEEENRRILQRRTAASVPESVKENGDADSIHTQETQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7YU96</accession>
    <name>C7YU96_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_48812</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IMPACT family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050477.1">
        <property type="nucleotide sequence ID" value="XM_003050431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YU96"/>
    <dbReference type="FunCoup" id="C7YU96">
        <property type="interactions" value="389"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YU96"/>
    <dbReference type="GeneID" id="9674873"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_48812"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_48812"/>
    <dbReference type="eggNOG" id="KOG3299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045276_0_1_1"/>
    <dbReference type="InParanoid" id="C7YU96"/>
    <dbReference type="OMA" id="HLMQVMD"/>
    <dbReference type="OrthoDB" id="69641at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23822">
        <property type="entry name" value="RWD_ScYIH1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="entry name" value="Impact, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020569">
        <property type="entry name" value="UPF0029_Impact_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="IMPACT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301:SF25">
        <property type="entry name" value="PROTEIN IMPACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="Impact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00910">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="RWD" evidence="8">
        <location>
            <begin position="7"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU44764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="264" mass="28951" checksum="164E5A1689AC14F1" modified="2009-10-13" version="1">MSEELQDEVEAINSIYGDGSLVPTEGDTSVFILNLPGDASSLRVRFPQEYPSKPPSVLGTHHSSGGVRGAGARDLKLFREALESVFQEGLVCLFDAVEEFTRRSEEEAEDEAPSAPSPPPEEYEIEEPSFPPPKWILSEPITDSKSTFIAHVARVTSPDQARHYVQVLLASDKRIRTATHNMTAWRIKGPGAASFQDCDDDGEAAAGGRLLHLMQLMDIWDAMVVVTRWYGGVQLGPKRFALINAVARDGFVKAGLVEEKKKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7YUB7</accession>
    <name>C7YUB7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED6</name>
        <name evidence="10" type="ORF">NECHADRAFT_84866</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050097.1">
        <property type="nucleotide sequence ID" value="XM_003050051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YUB7"/>
    <dbReference type="FunCoup" id="C7YUB7">
        <property type="interactions" value="782"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YUB7"/>
    <dbReference type="GeneID" id="9665462"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84866"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84866"/>
    <dbReference type="eggNOG" id="KOG3169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060172_0_0_1"/>
    <dbReference type="InParanoid" id="C7YUB7"/>
    <dbReference type="OMA" id="ASHGHTY"/>
    <dbReference type="OrthoDB" id="344220at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.580">
        <property type="entry name" value="Mediator complex, subunit Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007018">
        <property type="entry name" value="Mediator_Med6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038566">
        <property type="entry name" value="Mediator_Med6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13104">
        <property type="entry name" value="MED-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04934">
        <property type="entry name" value="Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="171"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="238"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU44384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="316" mass="34486" checksum="E7230F5D1C5C395F" modified="2009-10-13" version="1">MANPNDPPLDEIQWRSPIAIANMGGLHSNSILFYFAESPFFERTSNNAVVYNQAMNNSAMFSDIQTREAFEGRLNTMAGLEFRVAEEPAETGPGAGTGVWVIRKQTRRKHYEARDEIIVHASYFVVGENIYMAPTLNDILAARIMTMSSAIARAASSAESIRKWRPSLGHVYQLPSNQPPARSKAQDSAAATPMPEEASKASALPATASQKDDEASLERLVEESLMVHMKYGGEYIDENPITGRPGEFHLSSTGRKVIPPPQLAKSEGIGSISGPTINTKVDDKKDDKSKTPKSATMSKPRRKKSKMLSTSTPAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C7YV24</accession>
    <name>C7YV24_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GIY-YIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_49413</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Forms a heterodimer with SLX4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the SLX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050623.1">
        <property type="nucleotide sequence ID" value="XM_003050577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YV24"/>
    <dbReference type="FunCoup" id="C7YV24">
        <property type="interactions" value="419"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YV24"/>
    <dbReference type="GeneID" id="9674578"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_49413"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_49413"/>
    <dbReference type="eggNOG" id="KOG3005">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030739_1_1_1"/>
    <dbReference type="InParanoid" id="C7YV24"/>
    <dbReference type="OMA" id="HNRGCDF"/>
    <dbReference type="OrthoDB" id="24645at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03100">
        <property type="entry name" value="Endonuc_su_Slx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027520">
        <property type="entry name" value="Slx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048749">
        <property type="entry name" value="SLX1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050381">
        <property type="entry name" value="SLX1_endonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208:SF10">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21202">
        <property type="entry name" value="SLX1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="10">
        <location>
            <begin position="10"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU44910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="311" mass="35124" checksum="0B666BBF119475A3" modified="2009-10-13" version="1">MSQLSRPHPALYGVYVLRSTVRHASIYIGSTPNPPRRLKQHNGEARGGAVRTAREKLRPWEVMILVTGFPSSIAALKFEWAMTNPHLTTHISAEERLTKAAEKRKGMKKPRKPIHTLTSVVSNLHLLTNVPSFARWPLTVHFFASEPKKAWDKWLQSIDAVPRQGMNVFTDFGPSKETQRESSPAPWGIYALPLDYAPMKGYIEKAHNVVSFEREGKCVHCHEELESGKGLHPMCPNGRCEAMGHLDCWSKHALKGEDEGAMIPRSCTCPSCYSEIQWGDMMKELTLRVRGPKEVEKLLKKPRRTRKAAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVA6</accession>
    <name>C7YVA6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_85207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050663.1">
        <property type="nucleotide sequence ID" value="XM_003050617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVA6"/>
    <dbReference type="GeneID" id="9675047"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85207"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85207"/>
    <dbReference type="HOGENOM" id="CLU_573700_0_0_1"/>
    <dbReference type="InParanoid" id="C7YVA6"/>
    <dbReference type="OMA" id="FECHARM"/>
    <dbReference type="OrthoDB" id="3779652at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU44950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="583" mass="67886" checksum="B79BEF7535CD900B" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVV4</accession>
    <name>C7YVV4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_89636</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU43854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049567.1">
        <property type="nucleotide sequence ID" value="XM_003049521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVV4"/>
    <dbReference type="GeneID" id="9677355"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89636"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89636"/>
    <dbReference type="eggNOG" id="KOG1638">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065395_0_0_1"/>
    <dbReference type="InParanoid" id="C7YVV4"/>
    <dbReference type="OMA" id="PHYALEW"/>
    <dbReference type="OrthoDB" id="5788137at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003865">
        <property type="term" value="F:3-oxo-5-alpha-steroid 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016636">
        <property type="entry name" value="3-oxo-5-alpha-steroid_4-DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF43">
        <property type="entry name" value="STEROID 5-ALPHA-REDUCTASE DET2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015596">
        <property type="entry name" value="5_alpha-SR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="7">
        <location>
            <begin position="118"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU43854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="284" mass="32841" checksum="11A134A0EA906C44" modified="2009-10-13" version="1">MAIVEGWLPPTREHYDLILKIWQISYPIVGSIQWLTKWYGMGKTSVASRLNLPGRIGWLTMEAPGFLTLLYLMKTLPEQHSIDDLPWQNKVLAGLFVIHYSYRAVMFPYLQPSMSPLHIAVWLLGVSFQIFNATCLGSWLAAYGPTTEEAWASQSSILQFSAGILIFYLGLSGNFFHDEELREIRRREAQRAQRDEAKANVEKHYQIPQAGLFRYMLYPHYLCEWVEWAGFWMAAGWGCAPARAFLINEIFAMLPRAVRGKRWYLERFGEDKVGKKWAVIPGVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVY1</accession>
    <name>C7YVY1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_29709</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU43867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003049534.1"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YVY1"/>
    <dbReference type="GeneID" id="9677155"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_29709"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_29709"/>
    <dbReference type="eggNOG" id="KOG1620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001850_1_0_1"/>
    <dbReference type="InParanoid" id="C7YVY1"/>
    <dbReference type="OMA" id="WGATMVN"/>
    <dbReference type="OrthoDB" id="2573163at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF21">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="372"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="455"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="840"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="929"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="985"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1010"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="190"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="473"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="508"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="566"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="589"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="614"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="847"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="930"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="985"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1035"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1108"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1177"/>
            <end position="1187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU43867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1480" mass="163313" checksum="F6D48384ABCE16F9" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWS7</accession>
    <name>C7YWS7_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_82769</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049425.1">
        <property type="nucleotide sequence ID" value="XM_003049379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWS7"/>
    <dbReference type="GeneID" id="9666556"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82769"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82769"/>
    <dbReference type="HOGENOM" id="CLU_1971116_0_0_1"/>
    <dbReference type="InParanoid" id="C7YWS7"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU43712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="127" mass="14718" checksum="CD85BBB4E39F15F8" modified="2009-10-13" version="1">MVELTPEECFMVSIYDILQHRRTCPDEGCKFHKAAWRQDCEKELVFRIIQKIIQAEEALAREGTMYEDSIKVATALRAFKLLCLEQFWSFMDPDVAVDNMLKLLFANPDTQQAGEATNNTTARLRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWZ0</accession>
    <name>C7YWZ0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_101119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049449.1">
        <property type="nucleotide sequence ID" value="XM_003049403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWZ0"/>
    <dbReference type="GeneID" id="9666580"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101119"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101119"/>
    <dbReference type="eggNOG" id="KOG1546">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016732_1_0_1"/>
    <dbReference type="InParanoid" id="C7YWZ0"/>
    <dbReference type="OMA" id="IHRHLCA"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="2">
        <location>
            <begin position="91"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU43736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="736" mass="81566" checksum="EC3162D6C23185A4" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7YX20</accession>
    <name>C7YX20_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_82863</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049467.1">
        <property type="nucleotide sequence ID" value="XM_003049421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YX20"/>
    <dbReference type="GeneID" id="9676898"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82863"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82863"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="C7YX20"/>
    <dbReference type="OMA" id="RPKWYIS"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF18">
        <property type="entry name" value="NICOTINIC ACID TRANSPORTER TNA1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="61"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU43754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="513" mass="57105" checksum="E8DF669AD7678014" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXA6</accession>
    <name>C7YXA6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Purple acid phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_70723</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="4"/>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049507.1">
        <property type="nucleotide sequence ID" value="XM_003049461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXA6"/>
    <dbReference type="STRING" id="660122.C7YXA6"/>
    <dbReference type="GeneID" id="9676938"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_70723"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_70723"/>
    <dbReference type="eggNOG" id="KOG1378">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013387_2_2_1"/>
    <dbReference type="InParanoid" id="C7YXA6"/>
    <dbReference type="OMA" id="THIVNGM"/>
    <dbReference type="OrthoDB" id="45007at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014390">
        <property type="entry name" value="Acid_Pase_Asper"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PAPs-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="ACID PHOSPHATASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953:SF153">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000900">
        <property type="entry name" value="Acid_Ptase_Asper"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005125798" description="Purple acid phosphatase" evidence="4">
        <location>
            <begin position="23"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="8">
        <location>
            <begin position="82"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="277"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase C-terminal" evidence="7">
        <location>
            <begin position="536"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="608"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="615"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU43794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="656" mass="71763" checksum="0FCEF3987F8789A5" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXU0</accession>
    <name>C7YXU0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_45149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049360.1">
        <property type="nucleotide sequence ID" value="XM_003049314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXU0"/>
    <dbReference type="GeneID" id="9666416"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45149"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45149"/>
    <dbReference type="eggNOG" id="ENOG502SPQC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014597_2_1_1"/>
    <dbReference type="InParanoid" id="C7YXU0"/>
    <dbReference type="OMA" id="IWIAERD"/>
    <dbReference type="OrthoDB" id="10054429at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF11">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU43647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="52476" checksum="5D33E0181161DE72" modified="2009-10-13" version="1">MDLNGNEKQLSSRVSSNNSDLSLYVPAGEDSILLGHYFSFVCEVASSFDSSANPFRSRVTKMMDASPLLFTCVMSISAAHLYQNQGDSSSIPLSFQTEAISRISRELAKISTHVPPHPPGVLALARPSAASLVKDDILLGIILLGMTSSWHDPSSLGLYHLTGSRHLFKLWMATNGLEQPPRPLSMTQNFIVSSMVYWEVMVSYLLDQDLEAISYLDVFLDPAPESLSQPCPWTGVATDIFIRLAKVGTMVRKRRTLRSRKLASGETSALIQLIAEASTLEQAILKSRAPLIGLVKDTGDPRSPPSHLVKMARSYRLASLLELYRAFPEIATSSTSRFDEAETTDKQSQLVLGLAFDILEILETIPDNSRTIAIQSLVYLIAGSTLGHLAAVEGHQLTAAQSRQNQLINNWRQFVRNRFYKSFLSIGLHTINRVGTILEEVWSRMDSVVSSAGQGHVMDVHWIDAMTGKKLETILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXX3</accession>
    <name>C7YXX3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FMN hydroxy acid dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_82680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049381.1">
        <property type="nucleotide sequence ID" value="XM_003049335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXX3"/>
    <dbReference type="STRING" id="660122.C7YXX3"/>
    <dbReference type="GeneID" id="9677017"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82680"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82680"/>
    <dbReference type="eggNOG" id="KOG0538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1461703_0_0_1"/>
    <dbReference type="InParanoid" id="C7YXX3"/>
    <dbReference type="OMA" id="IAPMAMH"/>
    <dbReference type="OrthoDB" id="3940601at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF149">
        <property type="entry name" value="2-HYDROXYACID OXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU43668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="185" mass="20591" checksum="488B3E5FCC3A3CE2" modified="2009-10-13" version="1">MTERLAYLPVAMLSLRHLVCPQPSLHIMNPIPGDQMDGLEWLDFKQIPRMTWHGHIDPGGEVATSRATAKKGVAMALSSYSSMNLEDVAAESQGNPYMIHVCFYKDRRKTLEITKRAETAGFKAVLVSVDIPVLGIRPNEHRNNWGVPEGITMPMLADENGIMHHDADYLKVDPAADADEVLDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7YY71</accession>
    <name>C7YY71_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_95379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU42952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048665.1">
        <property type="nucleotide sequence ID" value="XM_003048619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YY71"/>
    <dbReference type="GeneID" id="9667790"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95379"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95379"/>
    <dbReference type="eggNOG" id="ENOG502SX07">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025636_0_0_1"/>
    <dbReference type="InParanoid" id="C7YY71"/>
    <dbReference type="OMA" id="WEEQATH"/>
    <dbReference type="OrthoDB" id="3481168at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988670" description="Metallo-beta-lactamase domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="58642" checksum="6FA4E12992F6CCF7" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYN4</accession>
    <name>C7YYN4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_83750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048747.1">
        <property type="nucleotide sequence ID" value="XM_003048701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYN4"/>
    <dbReference type="GeneID" id="9665931"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83750"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83750"/>
    <dbReference type="eggNOG" id="ENOG502RJ7Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1200109_0_0_1"/>
    <dbReference type="InParanoid" id="C7YYN4"/>
    <dbReference type="OMA" id="NHRVARY"/>
    <dbReference type="OrthoDB" id="5092327at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU43034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="231" mass="25834" checksum="D7AA0A898EE025F9" modified="2009-10-13" version="1">MQNPDGNIPSQRFIRLILKAFLIIFSIGSFVTFILAAITAGGDWPQMQQSALSDATSRFITVPRDGRGLVRRDDDDDFRRGPFGRGNARFANDRDFQSNVQLFRLDPNDPAWLPFFFLSAIAFLSWLATATLLYFVFARGRSFGSRFPRYVFRVIALIVLAFAPVFVFGWYRNDGSFSLVCKSNYAIGQAALVLAHLTFFAGIYLTFLGAIFDLPTDFGVDSRRTSATSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZ33</accession>
    <name>C7YZ33_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Histone H3 methyltransferase complex and RNA cleavage factor II complex, subunit SWD2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SWDB2101</name>
        <name evidence="7" type="ORF">NECHADRAFT_46489</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SWD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048821.1">
        <property type="nucleotide sequence ID" value="XM_003048775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZ33"/>
    <dbReference type="FunCoup" id="C7YZ33">
        <property type="interactions" value="1025"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YZ33"/>
    <dbReference type="GeneID" id="9666081"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_46489"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_46489"/>
    <dbReference type="eggNOG" id="KOG1446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044117_2_0_1"/>
    <dbReference type="InParanoid" id="C7YZ33"/>
    <dbReference type="OMA" id="HNEGYIR"/>
    <dbReference type="OrthoDB" id="27537at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="61"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="138"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU43108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="373" mass="40986" checksum="4D7D9FBC996225D7" modified="2009-10-13" version="1">MASTPMDIDRSNTPNGSSLNIHRTIGATASVSNLSDVISNFRPTKLFRRDDIKDGRPQPHVLSIDFDDEGELIMTSASDETIQIYNVKEGRHDKSLLSKKYGVKLAKFTHTGSSIIYASTKQNGTRPYLARPTPRNIVTCLSVHPGSDNFISCSRDNTVRLWDTQTKNCQGQLFLRSPYLAAYDPSGTVFAVACPSSGTVLLYDARNYDKAPFATVDVVEQCRRVDSQCLVKGWTKLEFSNDGKSLLVGTRGNGHFLLDAFEGTLKAYLRKPNGGTKRLAVGEAVSGASTDGTTFESSGECCFTPDGRYILSGSKKDVLVWDSMTAPGDNKVLEPSWTLPDKREASVLGFNPRFNFFATADQELVFWLPDPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZD5</accession>
    <name>C7YZD5_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_83992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048498.1">
        <property type="nucleotide sequence ID" value="XM_003048452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZD5"/>
    <dbReference type="GeneID" id="9667575"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83992"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83992"/>
    <dbReference type="HOGENOM" id="CLU_1886314_0_0_1"/>
    <dbReference type="InParanoid" id="C7YZD5"/>
    <dbReference type="OrthoDB" id="5105937at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="135" mass="15600" checksum="2F14752DD40462E2" modified="2009-10-13" version="1">MNHQQAKLGQVAEILTPSVNTAVRAILAFLTIMFLRAILGYTILAKIIIILISGDLEAEHLPFPYLVMSFLVYFGLFELSCSNTNLFCASYNFCASYRKRRHNFNPLIENESWWDADRDRLKEKLVMSVNYSPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZQ6</accession>
    <name>C7YZQ6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein HRI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_47547</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HRI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048553.1">
        <property type="nucleotide sequence ID" value="XM_003048507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZQ6"/>
    <dbReference type="GeneID" id="9667440"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_47547"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_47547"/>
    <dbReference type="eggNOG" id="ENOG502S8GG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060351_1_0_1"/>
    <dbReference type="InParanoid" id="C7YZQ6"/>
    <dbReference type="OMA" id="TVERWEW"/>
    <dbReference type="OrthoDB" id="4045395at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd11693">
        <property type="entry name" value="HRI1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11692">
        <property type="entry name" value="HRI1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.320">
        <property type="entry name" value="Protein HRI1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031818">
        <property type="entry name" value="Hri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038744">
        <property type="entry name" value="Hri1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043047">
        <property type="entry name" value="Hri1_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16815">
        <property type="entry name" value="HRI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU42840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="242" mass="27009" checksum="FED6C12749D3D45B" modified="2009-10-13" version="1">MGSISVRKWIRWVPEEASEPTSTLVLTSPGRHFVDLRIYLPEGHQGPWTDPLPLSRLEWGIAGISISTKRPDSTGKLASYSAFHQWISSRTLTPELFPDAGFMYSQPDNLVLEKGSMLNPDTGADGEYEELWHDVDPTAVPGEGGVRVLVVQLHDDEHRTRGSVVRLGRHMQGFVRVGDDVALERWEWDEGWKRTVKIGEIGLPCEKILKGENLSEGDVVEVGGKPWMVVEESGKRDATSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z150</accession>
    <name>C7Z150_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_80115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048221.1">
        <property type="nucleotide sequence ID" value="XM_003048175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z150"/>
    <dbReference type="GeneID" id="9672001"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_80115"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_80115"/>
    <dbReference type="HOGENOM" id="CLU_2159049_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z150"/>
    <dbReference type="OrthoDB" id="4976098at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU42508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="111" mass="13020" checksum="A7075A6F87B4C831" modified="2009-10-13" version="1">MASEYQDAVALRTLTQANLRIIFPNIPVMEFFVYWNDKTIRAVVVDMTRLYWSELGGYRPSSLIHLEWKARADDPQGKLLEGHKVLFEETQTLLKHRLLDRLRVCRLNTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1K6</accession>
    <name>C7Z1K6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_85832</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
            <orientation evidence="1 6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="6">Cytoplasmic face of coated pits and vesicles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the clathrin light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU42020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047733.1">
        <property type="nucleotide sequence ID" value="XM_003047687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1K6"/>
    <dbReference type="FunCoup" id="C7Z1K6">
        <property type="interactions" value="319"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z1K6"/>
    <dbReference type="GeneID" id="9671686"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85832"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85832"/>
    <dbReference type="eggNOG" id="KOG4031">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069856_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z1K6"/>
    <dbReference type="OMA" id="FYENYNT"/>
    <dbReference type="OrthoDB" id="5512at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000996">
        <property type="entry name" value="Clathrin_L-chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639:SF7">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01086">
        <property type="entry name" value="Clathrin_lg_ch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="132"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU42020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="237" mass="25771" checksum="413A3FD16DAE3602" modified="2009-10-13" version="1">MADRFPSLEDFDSGAQTDIKDPSADPSTDDFLAREKALLGDDADQFATNDDAAAFVDAEGDLLGSGGNEQSTFESQFPDLTQPDAGTGLTPGGTAVTGPSVSYNSGYQAYAEEEEEPEVIKEWRERRDAQIAKRVEQFAAQREETIKEAQQNIDDFYDNYNNKKEKGIAQTRKEAEEFLANQEDTVSGGTSWDRIAKLVDVSGKGTKGGASGSGKERFRELLVSLRKDEKAPGATGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z2B3</accession>
    <name>C7Z2B3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_106439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU42142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047855.1">
        <property type="nucleotide sequence ID" value="XM_003047809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z2B3"/>
    <dbReference type="GeneID" id="9671821"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_106439"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_106439"/>
    <dbReference type="eggNOG" id="ENOG502STCJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117769_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z2B3"/>
    <dbReference type="OMA" id="IPCADAK"/>
    <dbReference type="OrthoDB" id="3799394at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002987809" evidence="1">
        <location>
            <begin position="18"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="146" mass="15404" checksum="46EF8CB43C9FB5FF" modified="2009-10-13" version="1">MLFTNLIAATLLGFAAAQQSPNGRGCGFKIAPCPADTKCVPNDYSCTNLHRCPGTCYFKNQYQTCGGFRMEPPPPCKKGTHCIDDPRIPGSCGMACDAPGICVPKKAPSCGGFIGKKCPKGLWCYDNPTDDCDPENGGADCIGICL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z2S1</accession>
    <name>C7Z2S1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_22507</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047241.1">
        <property type="nucleotide sequence ID" value="XM_003047195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z2S1"/>
    <dbReference type="GeneID" id="9676082"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_22507"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_22507"/>
    <dbReference type="eggNOG" id="ENOG502S9TN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008497_4_0_1"/>
    <dbReference type="InParanoid" id="C7Z2S1"/>
    <dbReference type="OMA" id="GRVHCAY"/>
    <dbReference type="OrthoDB" id="5399138at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU41528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="436" mass="48280" checksum="561DD04F150B331D" modified="2009-10-13" version="1" fragment="single">QQSGLPRRRSRYLRHQPQTPTEPIAIPTSTKSTDSGLDPMQRWQDSPPEAEPASLSAIVDALERAPLRSRSSAGSPGSQHFGSRAASTVSFGSGTSCSSASVASANSITHRSSSRGRVTKRTRTPAAKAKEPGKRIFLCTFCCDSFKSKYDWARHEKSLHLNLQGWRCAPFGGTVVSPSTGRSHCAYCSLLDPTPEHLSSHNHESCQNSDPTHFFSRKDHLVQHLRLVHHVQTMPIIDSWKVEGPPVSSRCGFCSIQLHTWQERVDHLTKHFRSGATMDSWKGEHCFEPSIAAQVTNAIPPYLIAAESRALVPFSSTDPGTKDHLSQIKHATQQSLGQWDDGGAMAMSGSEPSPQSSTQQGSLDGINERSPPMMYPDVLALHLGRYAQEKMKLGIIPTDRMFQEEARRIMFDSVDPWDQTIADNDDWLSCFRSRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z2W6</accession>
    <name>C7Z2W6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_87741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047266.1">
        <property type="nucleotide sequence ID" value="XM_003047220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z2W6"/>
    <dbReference type="GeneID" id="9675801"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87741"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87741"/>
    <dbReference type="eggNOG" id="ENOG502T53V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004184_3_6_1"/>
    <dbReference type="InParanoid" id="C7Z2W6"/>
    <dbReference type="OMA" id="RENWMAK"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="107"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU41553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="685" mass="77457" checksum="15FDFCA39F7452A0" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z363</accession>
    <name>C7Z363_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Accumulation-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_87842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047317.1">
        <property type="nucleotide sequence ID" value="XM_003047271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z363"/>
    <dbReference type="GeneID" id="9675922"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87842"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87842"/>
    <dbReference type="eggNOG" id="ENOG502SQTD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079445_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z363"/>
    <dbReference type="OMA" id="TICRTLV"/>
    <dbReference type="OrthoDB" id="3014608at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002986754" description="Accumulation-associated protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU41604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="27682" checksum="4A13EBB16058B0AD" modified="2009-10-13" version="1">MKLFTITLLATQLSAILAAPAAIQHDSRAIVRPRSPHARFSLVATVTSTIVPSQTSAAAGGGAEGGEGAEGGEEGAEDEVEQAGEFDVPIVLPGGSKVDTLYPPGQNGVFEIEFQNAEDRTLTVTQNTSPAAPPAGFRAVEPVSFIVNLAEGTEGLTLQKVDYILNANSTLDISTGAIGRFCTEAGAFVIDPAVGELEFEVEENELLIKVDNMNGEWGIFIPDAAATPAAGEGAAPSEEATPGGDAATPGGGATPDTKQQLIDLLLGLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z3L9</accession>
    <name>C7Z3L9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_101164</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046871.1">
        <property type="nucleotide sequence ID" value="XM_003046825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z3L9"/>
    <dbReference type="GeneID" id="9675773"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101164"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101164"/>
    <dbReference type="eggNOG" id="ENOG502QV3Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016574_6_1_1"/>
    <dbReference type="InParanoid" id="C7Z3L9"/>
    <dbReference type="OMA" id="QQCEHLD"/>
    <dbReference type="OrthoDB" id="2740448at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF24">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="8"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU41158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="497" mass="56049" checksum="AFECCA84FEA4E8D5" modified="2009-10-13" version="1">MSNRTTRACEPCRVRKVKCNGSTPCSQCAHLNLSCIYSTAPSKRKPGVRGRLVAQLRQGTTDSRSSTTPPQVQDSPSSLGTYTAEFFLNLVTAYEEVVFPVNPIIPSSEIVAAIENMERSFEDSALVYAFGAVTINLSEISQGLNDDITTRMTDLMHHSFRAHRRAELGSEIDSRLPVTVKRIMTCIFLEICLMALKRFDRSLAILREAIAMIQMLQVDQNVCERRIDDQELARRQRLYWEAFIHERFLTIMPGYPSILPPLRTGVPLPDSSIPQHVRAGFDRLIHLFLIMDDTFLSHWRALQDADLEVPEITADWIESKQAQLDEDEIGAAEAEKELMSGGYGGLSELQHADLFVTRLWLRTLVWQLALSQGLLQSVPPKNSHEGFSMHFPAQRLSAELRNLVGRLDRVESIGIHGSGILQKLFDITSTVADVLALPIGHEQDAESRIEDFLFLVKFLLSFERIPPNQKEYLKEKVNAVQREHASGFHSLAAYTFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z405</accession>
    <name>C7Z405_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_46452</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046944.1">
        <property type="nucleotide sequence ID" value="XM_003046898.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9678683"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_46452"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_46452"/>
    <dbReference type="eggNOG" id="KOG2029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002786_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z405"/>
    <dbReference type="OMA" id="WTFYETI"/>
    <dbReference type="OrthoDB" id="361039at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1763"/>
            <end position="1783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1803"/>
            <end position="1822"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="50"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="490"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="692"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1139"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1339"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1462"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1855"/>
            <end position="1887"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1702"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="497"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="732"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1205"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1247"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1272"/>
            <end position="1281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU41231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1913" mass="211443" checksum="9AEA3BFB7706C6DD" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4U5</accession>
    <name>C7Z4U5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_76640</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046121.1">
        <property type="nucleotide sequence ID" value="XM_003046075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4U5"/>
    <dbReference type="STRING" id="660122.C7Z4U5"/>
    <dbReference type="GeneID" id="9678227"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76640"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76640"/>
    <dbReference type="eggNOG" id="KOG0001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1180512_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z4U5"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000469">
        <property type="entry name" value="Polyubiquitin-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="10">
        <location>
            <begin position="194"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="79"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU40408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="235" mass="24587" checksum="03C902C1B7A63DF8" modified="2009-10-13" version="1">MKLANDPRCAPLANLVFFFQHHIFVSQPMGKPHSLQGVMITSDKVLDPLPHVVFGAGVDLSKLTPAQLYALGAGLAAGADAPAARMKKTKGGQKPRAKPKPKPKPEPKPPGQGTSVFAQRRREKAAAKAEAKAKAEAEAAPSSSPSTTSPSAAAAPAKTPAESEPEPEPAAEEAEAAVKKESTLHLILGLRGGMQIFVKTLTGKTITLEVEPSDTIDNVKSKIQDEEASVILQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z582</accession>
    <name>C7Z582_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Golgi apparatus membrane protein TVP18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_58502</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046189.1">
        <property type="nucleotide sequence ID" value="XM_003046143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z582"/>
    <dbReference type="FunCoup" id="C7Z582">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z582"/>
    <dbReference type="GeneID" id="9678572"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_58502"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_58502"/>
    <dbReference type="eggNOG" id="ENOG502S3AC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118698_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z582"/>
    <dbReference type="OMA" id="IYAQWLG"/>
    <dbReference type="OrthoDB" id="5591789at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019365">
        <property type="entry name" value="TVP18/Ca-channel_flower"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314:SF2">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10233">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01077">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU40476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="15923" checksum="ECF5B01D87E3B9CC" modified="2009-10-13" version="1">MTLKEEFQTRNFSIYGQWIGILSMIICLAVGIANIFSFNPVRIIFCALAIASAFVILFIEVPLLLRICPTSGKFDEVIRKISTNYMRAGAYGVMSTLQFVSNVSGASSLIAAAVFLLIAALCYLLAGIKGQAFVGSKTLGGAGVAQMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z602</accession>
    <name>C7Z602_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_90656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045755.1">
        <property type="nucleotide sequence ID" value="XM_003045709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z602"/>
    <dbReference type="GeneID" id="9668514"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90656"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90656"/>
    <dbReference type="eggNOG" id="ENOG502SGYQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_6_2_1"/>
    <dbReference type="InParanoid" id="C7Z602"/>
    <dbReference type="OMA" id="NSEHENA"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU40042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="25185" checksum="3404B3B47060B89C" modified="2009-10-13" version="1">MNTRAVALPKSLPDPAQWNQLIARYKEFRLLSLQLSPESFGSSYAREVAFSEEIWASRLNNPVALNTVIVSEPDDGAEDIDNISLILSSPWLAALTLVGPLEAKTAAKSYEDKMHLQPDTVSFGPPAPGVDSTYVLNAMYVLPSERRKGHSYKIIDFAKQLALIKENNRAVTLALILGDDNVPAMKSYEKSGFEVVHRYWFDDTRGGEVKKTRAAVMRADVRVEDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6M6</accession>
    <name>C7Z6M6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec1 family superfamily</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_76154</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046430.1">
        <property type="nucleotide sequence ID" value="XM_003046384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6M6"/>
    <dbReference type="FunCoup" id="C7Z6M6">
        <property type="interactions" value="805"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z6M6"/>
    <dbReference type="GeneID" id="9668708"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76154"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76154"/>
    <dbReference type="eggNOG" id="KOG1300">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009210_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z6M6"/>
    <dbReference type="OMA" id="PFTRPHT"/>
    <dbReference type="OrthoDB" id="2228at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="566"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="587"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="604"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="643"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="665"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU40717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="678" mass="76984" checksum="A964D6F9D03A8C61" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6P8</accession>
    <name>C7Z6P8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase III subunit Rpc5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_76172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045883.1">
        <property type="nucleotide sequence ID" value="XM_003045837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6P8"/>
    <dbReference type="STRING" id="660122.C7Z6P8"/>
    <dbReference type="GeneID" id="9668717"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76172"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76172"/>
    <dbReference type="eggNOG" id="KOG2354">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045565_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z6P8"/>
    <dbReference type="OMA" id="QHPNRTD"/>
    <dbReference type="OrthoDB" id="340681at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006886">
        <property type="entry name" value="RNA_pol_III_Rpc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES III 80 KDA POLYPEPTIDE RNA POLYMERASE III SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04801">
        <property type="entry name" value="RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU40170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="38421" checksum="EAFDD7993CF5ABE4" modified="2009-10-13" version="1">MATRPDESVTPMDVDDIDPKLQQSASTNTIDDDDDDDPVTATYNVFINPSLPLGRRLLILQHPNTASDTPQAAPTELRLKTRAGMVEVDLPLDHSVAYDREKGLKWGKGLQASMAAKNGGSHGLAGGFGVGGVQGRGGRKKTEEDADNLDWAEAVRQDKVLRTQTLGGHYPKTQKQLHMVGVFQGKELHLTPVSSLVMLRPQLHHIDAAVQLDRQANSKDAGPSSGAGTARAIHMTVKTTGDGDTVTTETMADRLRAVQSENWRNLRFTDENEEAAWEVYNESLFLRPTEDETQDEETKGKETKVDAAAKEERPLEDSVPHLGRKWDDDEYFEAVFKVKKPKPGFPSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6Y1</accession>
    <name>C7Z6Y1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CoA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_90862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045921.1">
        <property type="nucleotide sequence ID" value="XM_003045875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6Y1"/>
    <dbReference type="GeneID" id="9668198"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90862"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90862"/>
    <dbReference type="eggNOG" id="ENOG502S6U8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112567_1_1_1"/>
    <dbReference type="InParanoid" id="C7Z6Y1"/>
    <dbReference type="OMA" id="IYNACVL"/>
    <dbReference type="OrthoDB" id="5138418at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303:SF2">
        <property type="entry name" value="COA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303">
        <property type="entry name" value="CYTOPLASMIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA-binding" evidence="1">
        <location>
            <begin position="10"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU40208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="153" mass="16240" checksum="33287055B48D85A0" modified="2009-10-13" version="1">MTTEATVRKFFASSAFAVVGASSNPAKFGHRVFVWYLYHDLPVTPINPGSATISALEKDYPTVPNITALPNPKQTSISVITPPSATLKVLQEAKELGIPSVWLQPGSFDDDVLKFANEQGGFDAVVAGDGGRGHEGWCILVDGERGLKAAGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7D5</accession>
    <name>C7Z7D5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">tRNA (guanine(26)-N(2))-dimethyltransferase</fullName>
            <ecNumber evidence="7 9">2.1.1.216</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_33053</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:43140"/>
            <dbReference type="Rhea" id="RHEA-COMP:10359"/>
            <dbReference type="Rhea" id="RHEA-COMP:10360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74513"/>
            <dbReference type="EC" id="2.1.1.216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216" evidence="7 9"/>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045996.1">
        <property type="nucleotide sequence ID" value="XM_003045950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7D5"/>
    <dbReference type="FunCoup" id="C7Z7D5">
        <property type="interactions" value="1183"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z7D5"/>
    <dbReference type="GeneID" id="9668352"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_33053"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_33053"/>
    <dbReference type="eggNOG" id="KOG1253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010862_2_0_1"/>
    <dbReference type="InParanoid" id="C7Z7D5"/>
    <dbReference type="OMA" id="MKCCHEM"/>
    <dbReference type="OrthoDB" id="6349953at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160104">
        <property type="term" value="F:tRNA (guanine(26)-N2)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002940">
        <property type="term" value="P:tRNA N2-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.70:FF:000001">
        <property type="entry name" value="tRNA (guanine(26)-N(2))-dimethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="entry name" value="N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00308">
        <property type="entry name" value="TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631:SF3">
        <property type="entry name" value="TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 9" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="74"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU40283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="617" mass="68533" checksum="6C1C8700E7D22ADA" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7H9</accession>
    <name>C7Z7H9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-xylosidase C-terminal Concanavalin A-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_91030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046019.1">
        <property type="nucleotide sequence ID" value="XM_003045973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7H9"/>
    <dbReference type="GeneID" id="9668373"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_91030"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_91030"/>
    <dbReference type="eggNOG" id="ENOG502SHCU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016508_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z7H9"/>
    <dbReference type="OMA" id="GHQINIA"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18617">
        <property type="entry name" value="GH43_XynB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF12">
        <property type="entry name" value="BETA-XYLOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="7">
        <location>
            <begin position="350"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU40306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="522" mass="58106" checksum="D7431D1074F68660" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7R5</accession>
    <name>C7Z7R5_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_39473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045586.1">
        <property type="nucleotide sequence ID" value="XM_003045540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7R5"/>
    <dbReference type="GeneID" id="9672602"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_39473"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_39473"/>
    <dbReference type="eggNOG" id="ENOG502S67X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041445_2_1_1"/>
    <dbReference type="InParanoid" id="C7Z7R5"/>
    <dbReference type="OMA" id="LEWTSSC"/>
    <dbReference type="OrthoDB" id="3205825at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179">
        <property type="entry name" value="PROTEIN CBG02620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU39873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="288" mass="32472" checksum="306084720D28B1E3" modified="2009-10-13" version="1" fragment="single">FRTVKPSIDDMNIASIAWGVSLVFLWCIQLQALIQIIINRIAILMVVRQNARKLKIGAFIIILFVNISVFCIWIPARLGINKTWKDINNVWDRIEKVIFLLVDAGLNLYFIHLVRSRLIANGLTKYGRLFRFNLGMIAVSMTMDVLLIAMMSLPNDIVYVQFHPLAYLVKLHIEMNMADLITKVVKASNPSGYPDYSGSRSRTTQQGKSSGRGVTGKHTASMFAGGNTTYIEAGAEDIELPTRNEHGIQKTVRTEVVVKPSRQSQYDDPDMASESSSTRQLKREHFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7S4</accession>
    <name>C7Z7S4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_100270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045590.1">
        <property type="nucleotide sequence ID" value="XM_003045544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7S4"/>
    <dbReference type="FunCoup" id="C7Z7S4">
        <property type="interactions" value="1156"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z7S4"/>
    <dbReference type="GeneID" id="9672617"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100270"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100270"/>
    <dbReference type="eggNOG" id="KOG3320">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088621_1_2_1"/>
    <dbReference type="InParanoid" id="C7Z7S4"/>
    <dbReference type="OMA" id="AAYHKVQ"/>
    <dbReference type="OrthoDB" id="1724687at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000554">
        <property type="entry name" value="Ribosomal_eS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047861">
        <property type="entry name" value="Ribosomal_eS7_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01251">
        <property type="entry name" value="Ribosomal_S7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00948">
        <property type="entry name" value="RIBOSOMAL_S7E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU39877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="203" mass="23158" checksum="442CC6CBE0178B48" modified="2009-10-13" version="1">MSAQALNKIAPNSPSRQNPSELESSIAQALYDLETNTADLKVALRPLQFVSAREIEVGHGKKAIVIFVPVPSLQGFHRVQQRLTRELEKKFSDRHVLILASRRILPRPKRSARSRNTQKQKRPRSRTLTAVHDAILEDLTYPVEIVGKRVRTKEDGSKLLKVILDEKERGGVDYRLDTYSEVYRRLTGRNVNFEFPQSGPADY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7Y9</accession>
    <name>C7Z7Y9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Azaphilone pigments biosynthesis cluster protein L N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_68825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045620.1">
        <property type="nucleotide sequence ID" value="XM_003045574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7Y9"/>
    <dbReference type="STRING" id="660122.C7Z7Y9"/>
    <dbReference type="GeneID" id="9672390"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_68825"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_68825"/>
    <dbReference type="eggNOG" id="ENOG502SICT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032923_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z7Y9"/>
    <dbReference type="OMA" id="QCMDICS"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988892" description="Azaphilone pigments biosynthesis cluster protein L N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="4">
        <location>
            <begin position="2"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="375"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU39907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="450" mass="49847" checksum="A3D846526E08BC2B" modified="2009-10-13" version="1">MAEPVGLASAILALGTFALKASVSLYDDVNTFRNHPKRVRDLLEELNALRGVLEMLMETAGAATDVNFSALHIPLQRCGEACKEFGQELAKCCARSNADRTSFRDWAKMKYMGNDIDDFRQQLASYKSTINIALIDASLRASSITAKTLDGHKELIRNATDDLEAHLESINEKLEAMIDRTVPASDTDAADLCRIQNERASTEKGLQICRQLSDHIKEIQLNHAGRGKDLPRILDSGLLPDRIVSESLQQCTGSLSVATEQLERLQRKLMDQLMAKSRSAMAEEDGADLERLRSELETTRQSIMICHQVDMRLQQNVSVIENYATGDQTVQFLASTNEKTINGKNSGFGWAQRQIGGHFDNETVRQLSQDAFKPVTRYGKSDESQSQDQTPSHPRPIPNDQDVSKFSDRWGGGHRLISTSCSDRAVQISPVPNQDLPSGSSTGKQKSPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z810</accession>
    <name>C7Z810_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_39608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045632.1">
        <property type="nucleotide sequence ID" value="XM_003045586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z810"/>
    <dbReference type="STRING" id="660122.C7Z810"/>
    <dbReference type="GeneID" id="9672399"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_39608"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_39608"/>
    <dbReference type="eggNOG" id="KOG3328">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089876_12_0_1"/>
    <dbReference type="InParanoid" id="C7Z810"/>
    <dbReference type="OMA" id="IIDWAGG"/>
    <dbReference type="OrthoDB" id="46529at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACOT13"/>
    </dbReference>
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        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF11">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04355)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="72"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU39919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="171" mass="18285" checksum="240DE4795A37ECBF" modified="2009-10-13" version="1">MSSETPSTRIQTPDVTTSEIERTAHVQRLMDRLLEKSPIYNFIMSPVKLISATQGTVTTQMVLNGNHVNSRGGLHGAVSATIIDFVTGLAIASWDLRETTGASVDMHISYLSTAKVGDTVEIVSTADKVGGSMAFSTIRISKVGEDGSLTPVTVGQHTKYVRQSSAKTDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8U1</accession>
    <name>C7Z8U1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_104735</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045158.1">
        <property type="nucleotide sequence ID" value="XM_003045112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8U1"/>
    <dbReference type="FunCoup" id="C7Z8U1">
        <property type="interactions" value="185"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z8U1"/>
    <dbReference type="GeneID" id="9673655"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_104735"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_104735"/>
    <dbReference type="eggNOG" id="KOG1650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005126_10_0_1"/>
    <dbReference type="InParanoid" id="C7Z8U1"/>
    <dbReference type="OMA" id="CTFIVPP"/>
    <dbReference type="OrthoDB" id="2687058at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050794">
        <property type="entry name" value="CPA2_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468">
        <property type="entry name" value="CATION/H + ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468:SF0">
        <property type="entry name" value="K(+)_H(+) ANTIPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="9">
        <location>
            <begin position="54"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="509"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="850"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="509"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU39445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="870" mass="93347" checksum="698A82BEF3F3F4B7" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8X4</accession>
    <name>C7Z8X4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_100890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045174.1">
        <property type="nucleotide sequence ID" value="XM_003045128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8X4"/>
    <dbReference type="FunCoup" id="C7Z8X4">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z8X4"/>
    <dbReference type="GeneID" id="9673672"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100890"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100890"/>
    <dbReference type="eggNOG" id="KOG0283">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004759_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z8X4"/>
    <dbReference type="OMA" id="DTEGLKW"/>
    <dbReference type="OrthoDB" id="1932312at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040324">
        <property type="entry name" value="WDR44/Dgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221">
        <property type="entry name" value="WD REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="333"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="373"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="528"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="598"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="733"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="937"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="629"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="733"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="784"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="826"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="884"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="954"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU39461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="996" mass="109174" checksum="1AA3CCE28100A2AA" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9K2</accession>
    <name>C7Z9K2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein L34Ae</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_102720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044825.1">
        <property type="nucleotide sequence ID" value="XM_003044779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9K2"/>
    <dbReference type="FunCoup" id="C7Z9K2">
        <property type="interactions" value="908"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z9K2"/>
    <dbReference type="GeneID" id="9673810"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102720"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102720"/>
    <dbReference type="eggNOG" id="KOG1790">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118652_1_1_1"/>
    <dbReference type="InParanoid" id="C7Z9K2"/>
    <dbReference type="OMA" id="RCHKCVR"/>
    <dbReference type="OrthoDB" id="277449at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.370.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008195">
        <property type="entry name" value="Ribosomal_eL34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038562">
        <property type="entry name" value="Ribosomal_eL34_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018065">
        <property type="entry name" value="Ribosomal_eL34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46595">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01199">
        <property type="entry name" value="Ribosomal_L34e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01250">
        <property type="entry name" value="RIBOSOMALL34"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01145">
        <property type="entry name" value="RIBOSOMAL_L34E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU39112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="13201" checksum="90EA2F010561B1CE" modified="2009-10-13" version="1">MVSQRVTYRRRNGYNTTSNRTRVIKTPGGDLRLLHIKKRGTVPKCGDCGSKLSGIPALRPREYSQISKPQKTVQRAYGGSRCGGCVRDRIVRAFLIEEQKIVKKVLKEQEQSQKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9M2</accession>
    <name>C7Z9M2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_43317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045239.1">
        <property type="nucleotide sequence ID" value="XM_003045193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9M2"/>
    <dbReference type="GeneID" id="9673823"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_43317"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_43317"/>
    <dbReference type="eggNOG" id="ENOG502S67X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041445_2_1_1"/>
    <dbReference type="InParanoid" id="C7Z9M2"/>
    <dbReference type="OMA" id="FASIIWG"/>
    <dbReference type="OrthoDB" id="3205825at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179">
        <property type="entry name" value="PROTEIN CBG02620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU39526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="42468" checksum="B259EAFBDF13434C" modified="2009-10-13" version="1">MAPERGFLVPEHFKDDLPSEDDMNIASIIWGLSLGVVVFNCAKAFRQAKSAIHRRKRITTYVTLVWLEIISSFILGVMVWLYLRGIIPPSFQFYFFIIVFWSTQVQCLIQIIINRVALLMVVRANGTRLKWLCFLILLAINISVFCIWVPARLQINDTYVHINEIWDRCEKVIFAIMDAALNFYFIWVVKKRLISNGLQKYNRLYQMNLFLVAISIALDILLICMMSLPNSFVYVQFHPLVYLLKLHIEMNMADLIGKVVRASNNQDSNDYSSRSRTTGKSGSRPTHAGRFGATLTRTHIELGEEDEMELKERENLEGIKKTVVTEIVRTGPGHPGHEDDDIPEHHERAVSEASSTKAHQEPYSIEHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZA70</accession>
    <name>C7ZA70_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_81996</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044935.1">
        <property type="nucleotide sequence ID" value="XM_003044889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZA70"/>
    <dbReference type="GeneID" id="9672295"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_81996"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_81996"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_4_1"/>
    <dbReference type="InParanoid" id="C7ZA70"/>
    <dbReference type="OMA" id="LWAFPTE"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU39222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="52229" checksum="F633C07287DB5C6E" modified="2009-10-13" version="1">MALLSVPILAGALLAAVIVHNLLRVFTSPLSKIPNAGFGAAYSRLAWAFPREYKGTVTIDLPKLHEKLDPEQHAKRRRIMGQLFSRTKVPQLEKLISSHVDRFVQLIRENGPNVDLAVASRALEADIMSTFSFGKSIEAVDSWASGKELEMVAKNDLKATWMPVLTNFPLLCELLEQLEGAIFRVTGVRSAYTKGLTEFQQWCRDSWKLAISEDSELDEPATKSPNLIKSLCNSGLHAETALSEAKENLGPGTDTTSATLAHILWALAQNPDYQNALYEDLAAVSFYTDMTTLESVPRLQACVKEGIRWAGAAAAMLPRIVPPGGIELHGKFIPEGVREQTVLTSSPIWYQHDKTAFPNPKVYNPYRWLTDDCKGMSEDKLRDRFYIPFSRGANICMGAHFAYLELYISVSQVIRNFHLEICNITQRSTLEKNEETNWTPVPLPKRREWVAAVPMEKLEVKMCPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAB7</accession>
    <name>C7ZAB7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ceramidase</fullName>
            <ecNumber evidence="1">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_82043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.23" evidence="1"/>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044959.1">
        <property type="nucleotide sequence ID" value="XM_003044913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAB7"/>
    <dbReference type="GeneID" id="9672141"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82043"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82043"/>
    <dbReference type="eggNOG" id="ENOG502QVBG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051035_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZAB7"/>
    <dbReference type="OMA" id="MMHFRTL"/>
    <dbReference type="OrthoDB" id="5273684at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029130">
        <property type="entry name" value="Acid_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28583">
        <property type="entry name" value="ACID AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28583:SF1">
        <property type="entry name" value="ACID CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15508">
        <property type="entry name" value="NAAA-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acid ceramidase N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU39246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="439" mass="49913" checksum="93E50A548648DDF2" modified="2009-10-13" version="1">MEQESEIPTFRIDLARSPEDRYVDVAATFGPRIRTLGHVFDELLESMLGSKWLARIAKFLARVFLRRVHDEEETREIRGFVKVARCDLFLVVALNVFLDVMMGCTAGCVKVKGKQVQDERLMHFRTLDWGLDPLRDLVVVLEYVDSSKDPDHVIATSITYAGFMGVLTGVKENLSLSLNYRPLHLCDNSHLKKHQLLVILGFRPSVSSILRHTLFNQQKTEAPSSLVESAKQLSSVRSAPCYLTLCDGNHAVVIEKDLLTGRLRENDRFIVQTNHDSCDATRCGTELRSEPVTPHPELWLRDSNDRMDVISDKWSDHCSTEASSDDEAVVVDDNKSSVKQETLREWMMDKRISNGFTHFACIMDPATGRVPWLRRGPAPEVKVVEDAAKDEYLLYSNFYWAYQEGRSAIVGIRLLPMMTIITDIRHGLINSTMRDSNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAS8</accession>
    <name>C7ZAS8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_95105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044473.1">
        <property type="nucleotide sequence ID" value="XM_003044427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAS8"/>
    <dbReference type="GeneID" id="9672775"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95105"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95105"/>
    <dbReference type="eggNOG" id="ENOG502QSKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZAS8"/>
    <dbReference type="OMA" id="HKARRVW"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="33600" checksum="1E96910267CFC8F4" modified="2009-10-13" version="1">MSSSAAPASGPAETEAAGVTEPVAAATGQPPAVSTEDRDSGQDDDELAESTTSISDSVLQYRTIHGRTYHSERGNAQYWGSNDEQQNESMGINHHLLTLAIGDKLHLAPLKKDIENAVDIGTGTGIWAIDFADEHPGCKVIGTDISPIQPGWVPPNLELPGGYIESLESAPWLESDDGTVTDKTAMCQWGKLFVQGGLKIGRSFTLVDDEEQRKGMKAAGFVDIQEFNIKVPLGDWPKDPKLKEMGRFSRATLEQDTEGYVLYMATSEGWSREEVSVYAARLRREMRNSKIHAYFRMKVVWGKKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBK3</accession>
    <name>C7ZBK3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_88456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698915">
        <property type="protein sequence ID" value="EEU38583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044296.1">
        <property type="nucleotide sequence ID" value="XM_003044250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBK3"/>
    <dbReference type="GeneID" id="9670672"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88456"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88456"/>
    <dbReference type="eggNOG" id="ENOG502RAMP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1235318_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZBK3"/>
    <dbReference type="OrthoDB" id="5105815at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="224" mass="25095" checksum="FE8BBE490B34DEA8" modified="2009-10-13" version="1">MAPKRRLSSDDDAGGLPLQKRRITELLAALSDRGETNGSKVNHADLVEHHEPQANGTVNSSRHKRPAPDMEESSLPERNAKRPALNTTHGKSAEYESRLKIYQMLHECTHWDAFCYILNTAHELGDMTLALTLHDSPSAMRLKALKQLRPEWRERLIELVSDIEHEKELFDPRSLFPTVVTDSFLDFLSISNANMRGKAIVSKVLEGDMPHVGPCPCVPASDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBY0</accession>
    <name>C7ZBY0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_55379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698916">
        <property type="protein sequence ID" value="EEU38492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044205.1">
        <property type="nucleotide sequence ID" value="XM_003044159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBY0"/>
    <dbReference type="GeneID" id="9670546"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55379"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55379"/>
    <dbReference type="eggNOG" id="ENOG502S2QN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_9_0_1"/>
    <dbReference type="InParanoid" id="C7ZBY0"/>
    <dbReference type="OMA" id="FEARGME"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF3">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="36"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU38492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="307" mass="33289" checksum="0C76FD3EFE07B1D9" modified="2009-10-13" version="1">MTTRREYVFKVANGVPIAADVYFKKAVTASKLPIALHFHGGNFTVGSKELLVRHQAEKLVDLGFVVVSANYRLSPTVTVFEGPVKDALDAYKWSQTKLPELLSGDAGVNVDGSRVVTLGHSCGATLALLMAGLPRPPLAILDMYGIKYLSDQAYHTPLPAPPGSPKLDQDFVGLIWKDVPPPTYAPPPVGPSGPDFSSYRVAWMFDAMGKGTLFKTAVGDDNYDRVDPVSLFIKAHFPPTYFIHGTQDRLVPARLSQRAHDELKSRGVETELALVDGGQHGFDESAQPGDGVFGLLTKGFEFLKAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCG1</accession>
    <name>C7ZCG1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_77040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698918">
        <property type="protein sequence ID" value="EEU38256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043969.1">
        <property type="nucleotide sequence ID" value="XM_003043923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCG1"/>
    <dbReference type="STRING" id="660122.C7ZCG1"/>
    <dbReference type="GeneID" id="9670295"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77040"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77040"/>
    <dbReference type="eggNOG" id="KOG1695">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003953_3_0_1"/>
    <dbReference type="InParanoid" id="C7ZCG1"/>
    <dbReference type="OMA" id="FHWGLPH"/>
    <dbReference type="OrthoDB" id="5135333at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF12">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="270"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="815"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="819"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="852"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU38256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1009" mass="114383" checksum="AD983360457FD01B" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCP6</accession>
    <name>C7ZCP6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_91510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698918">
        <property type="protein sequence ID" value="EEU38405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044118.1">
        <property type="nucleotide sequence ID" value="XM_003044072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCP6"/>
    <dbReference type="STRING" id="660122.C7ZCP6"/>
    <dbReference type="GeneID" id="9670338"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_91510"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_91510"/>
    <dbReference type="eggNOG" id="ENOG502SVCF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024934_2_0_1"/>
    <dbReference type="InParanoid" id="C7ZCP6"/>
    <dbReference type="OMA" id="LGHDENT"/>
    <dbReference type="OrthoDB" id="4937900at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU38405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="380" mass="42788" checksum="385DC3F5C84E4674" modified="2009-10-13" version="1">MSDQSSQRQDTRRTHRKSRNGCVTCKQRRVKCDEGRPRCSKCVFGDRPCSYQNQKPETPTSPTPTPRVSETPQPRAEAGTFTAMDLAFLHHAECNLAEFMALQCDMKPIITLAVDNALTTPYLLDQLLALSALHRAVSDPAMASVYHQQATELQTRALSAFNETKADISESNHLTSFVFATLLGVHVLRNTLANNHHSLVAFISAFVAYIRLHRGVRAVTNQYWGLILQSELKPLLYIVDWADRADQLEPGTDTARMREFLQSTPGISSLSLDACLDALKQVQWVLDTIRLEPTRFDLAVHATMAWPLLVPDDYVDALYQHRPEALAVLSYYAAIVHRYREFWVFLGGAGSTLVELIARHIGPFWCEVMAWPQSEVFEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZD09</accession>
    <name>C7ZD09_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_84407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698919">
        <property type="protein sequence ID" value="EEU38012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043725.1">
        <property type="nucleotide sequence ID" value="XM_003043679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZD09"/>
    <dbReference type="STRING" id="660122.C7ZD09"/>
    <dbReference type="GeneID" id="9670213"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84407"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84407"/>
    <dbReference type="eggNOG" id="ENOG502SS3X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004184_7_2_1"/>
    <dbReference type="InParanoid" id="C7ZD09"/>
    <dbReference type="OMA" id="ERRTHEY"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="44"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="582" mass="64777" checksum="D45C0C4FFDA6D72B" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZD37</accession>
    <name>C7ZD37_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_48202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698919">
        <property type="protein sequence ID" value="EEU38153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043866.1">
        <property type="nucleotide sequence ID" value="XM_003043820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZD37"/>
    <dbReference type="STRING" id="660122.C7ZD37"/>
    <dbReference type="GeneID" id="9670025"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_48202"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_48202"/>
    <dbReference type="eggNOG" id="ENOG502SICY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002639_3_2_1"/>
    <dbReference type="InParanoid" id="C7ZD37"/>
    <dbReference type="OMA" id="WYLILED"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="239"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="738" mass="82734" checksum="A5E8AF1ECA4252B5" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEH7</accession>
    <name>C7ZEH7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_53387</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698921">
        <property type="protein sequence ID" value="EEU37699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043412.1">
        <property type="nucleotide sequence ID" value="XM_003043366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEH7"/>
    <dbReference type="GeneID" id="9669297"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_53387"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_53387"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="InParanoid" id="C7ZEH7"/>
    <dbReference type="OMA" id="MWLQYYA"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000050">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU37699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="56600" checksum="157C7DD9CEA0DDAF" modified="2009-10-13" version="1">MIRTFVQFLTPLNLSFLAVTVFILHSIRNKFRRGLRTLPGPTLAAYSGVWRYLDVRSGQAHKTAINLHRKHGSLVRIGPNHVSISDPREIKKIYGLKSGYTKVEVNLFGTRDEDYHRELKKPVANAFSLSTLLTNEPAVDSCTNLLIEKLSQYADASAPVDFGEWLQFYTFDVVGEITFAKKLGFLEKGGDVDGMIQAIEDLLVYASSIGQVPVWHNFLMGNPLLPILFPSMEGWNKVLTFTLKAVNAVIGNVDEDSKLKKDGEFNIESLDKQGDMLSKWFAVKLANPEKMSTRDIVVHLSTNVFAGSDTTAIALRAVFYNLLKSPAKMQKLVKEIDDAAAAGLLSSPISFKDSTKNLPYMQAVLKEGLRIHPSVGLLLERHVPAGGAVICGKPIPEGTIVGINAWVTQHDPEVFPNPDQFEPERWLDASEEQLKMMEQSFFAFGGGSRTCIGRHIAIMEMAKLIPEILRRFELSLPSPDHEWHTKNIWFVQQEGLICNLKRRQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEN3</accession>
    <name>C7ZEN3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_86286</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043075.1">
        <property type="nucleotide sequence ID" value="XM_003043029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEN3"/>
    <dbReference type="GeneID" id="9665174"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86286"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86286"/>
    <dbReference type="eggNOG" id="ENOG502S1A6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZEN3"/>
    <dbReference type="OMA" id="TRWGFLN"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF5">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="5">
        <location>
            <begin position="53"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU37362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="392" mass="43680" checksum="098A634F0ECD9121" modified="2009-10-13" version="1">MDSIKSKPAPELELPSSTKTVRVRAIDTTTRMACDAYAFVQPQIQGHEKLNFKTMCFLIEHEGEHILFDCGSRKDFWNGSPHTQSMIGGHVPAVEIEYGVDEILTMQGFGLQDLKAIVWSHWHWDHIGDGSKFPAGTDIVVGPGFTKNFVPGWPENPKSPVLTSDLQGHRIHEPEFSLTVAGFPAVDYFGDGSFYLLDVPGHAIGHICGLARTTPETFVFMGGDCCHYAGMFRPTEYLPLPRDISTPALDSYYPSPCPCSAFTQHHPKATGTEARTNPFYDVSRAAGSAYSFGDEAQKSLNKLQLLDAHSGIFVCLAHDDVLFDVLPLFNDDTTKDINDWQKRGLKEYCRWAFLNELPKGKKPGREPLVVGLWRQGKQVTWDKDKGFVDVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEU8</accession>
    <name>C7ZEU8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_86270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043149.1">
        <property type="nucleotide sequence ID" value="XM_003043103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEU8"/>
    <dbReference type="STRING" id="660122.C7ZEU8"/>
    <dbReference type="GeneID" id="9665168"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86270"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86270"/>
    <dbReference type="eggNOG" id="ENOG502SKP9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_8_5_1"/>
    <dbReference type="InParanoid" id="C7ZEU8"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF31">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="11"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU37436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="328" mass="35472" checksum="5D8282DB0DF632BA" modified="2009-10-13" version="1">MHQTYSPMNPKLVTVYGATGAQGGSVVRALLRDKFSSCTIRGITRSPDSEAAKALAAEGVEIVKVNIFDKDELAAVFKGSWAVFVNTNSDDPSIGSPGLPTKTQIGLLAVDAAVEVGDYVWSCPLSLFRWYSIGSHSSMLSSRPNVPAEKEHIGKYALSQSSLRSIVVNPAYYMENFNAKEWSEYLGGLPFYQDSAGYYTLSWPLWGGGGSNEVPLIAIERDFGDIVHGALLNADQLCGKTIQAASQSKPLEEIPTDFEHATGKRARVMQTVKDMFGFCYESGGLYYGEPNNVDVSASLKQAAAAAQGRSGENTRLYSLGEYVKDVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFE2</accession>
    <name>C7ZFE2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_37300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
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            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698923">
        <property type="protein sequence ID" value="EEU37230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003042897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFE2"/>
    <dbReference type="GeneID" id="9665083"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_37300"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_37300"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_2_4_1"/>
    <dbReference type="InParanoid" id="C7ZFE2"/>
    <dbReference type="OMA" id="WQVYLCY"/>
    <dbReference type="OrthoDB" id="2417308at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF11">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="497"/>
            <end position="518"/>
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    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFV2</accession>
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        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
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                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
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            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
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            <end position="285"/>
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        </location>
    </feature>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEU37124.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
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    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="706" mass="79586" checksum="153FD779B80977AC" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZG00</accession>
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    </protein>
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            <taxon>Sordariomycetes</taxon>
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            <taxon>Hypocreales</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
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                <person name="Rodriguez-Carres M."/>
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                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
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                <person name="White G.J."/>
                <person name="Zhou S."/>
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                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
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                <person name="Napoli C.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_52155"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="PERMEASE-RELATED"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU36970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="59561" checksum="2F3B211191EAA25D" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZG39</accession>
    <name>C7ZG39_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_52092</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698924">
        <property type="protein sequence ID" value="EEU37011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042724.1">
        <property type="nucleotide sequence ID" value="XM_003042678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZG39"/>
    <dbReference type="GeneID" id="9664929"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_52092"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_52092"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="InParanoid" id="C7ZG39"/>
    <dbReference type="OMA" id="STEMVSW"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF59">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU37011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="509" mass="56449" checksum="2792B7C26CA684E8" modified="2009-10-13" version="1">MPIKEIFTESVLAKYARTIKATPRDLMVNRNLLFSCAVYALAGLPTSESTQFNVISGAKASDIQNFISIIYIGYAVGAASSFFVNDRIGRRWSFRLYASIWILGQMIATASPGWAGLYTARIISGIGIGSLSVTGPMSIVELAPAEIRGLLTAWYTIAMGIALFTSVFCVYGIFLHMDPGRLQYQIVWFSPAIFMFFAILASFFICESPRWLMMVDKKDDAVSTLAKLRCLPTDHQRIEGEIQDIENSISGMGSSFVGIVKETFTVPSNLRRLQQALISYALAQLSGANSVTSYFVPIMSIMGLGGDTARSMFLSAMYGMSKFFFSIIASFFFIDALGRRRSLFVGISMQLISHVYIGVFIKFHQEGPVSSTASQAATAALFVHAFGYAVGLFVLPYIFGGELWPNRIRSFGGAVSQTFHWLFIYAVKYSIPSLLKTTDNWGAFLFFAGWCFLALIYVFFMVPEISGLSVEEIDYLFKGSWFNAYKRSRRGPVINSVESGDARSSIEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZG58</accession>
    <name>C7ZG58_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_52119</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698924">
        <property type="protein sequence ID" value="EEU37107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042820.1">
        <property type="nucleotide sequence ID" value="XM_003042774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZG58"/>
    <dbReference type="STRING" id="660122.C7ZG58"/>
    <dbReference type="GeneID" id="9664852"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_52119"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_52119"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_1"/>
    <dbReference type="InParanoid" id="C7ZG58"/>
    <dbReference type="OMA" id="GVIRAPM"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="6"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU37107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="237" mass="25044" checksum="8AECD91B44B7A2A4" modified="2009-10-13" version="1">MSLAGQAFVVTGGASGIGKAIVKKLLELSAKVYALDLSEIPIHSSTPGELVPFSKVDVSSRASVKSVFDKISPLDSELRGLVNCAGILRPTDGSEKSDESFRLLWDVNVMGTWNTNTEFHNFHRPASIVNLGSMASVRGIHGLSGYVASKHAVLGLTRTFAQEWGPEAFRVNAVAPGAVNTPMIQGMSGDDSHNAAYKGAFKSLSEPEEIADVILYLLGDGSSSISGQLIEVNGGWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZG60</accession>
    <name>C7ZG60_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_29610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698924">
        <property type="protein sequence ID" value="EEU37023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042736.1">
        <property type="nucleotide sequence ID" value="XM_003042690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZG60"/>
    <dbReference type="STRING" id="660122.C7ZG60"/>
    <dbReference type="GeneID" id="9664938"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_29610"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_29610"/>
    <dbReference type="eggNOG" id="KOG0907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_14_6_1"/>
    <dbReference type="InParanoid" id="C7ZG60"/>
    <dbReference type="OMA" id="WCIPSVF"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="site" description="Deprotonates C-terminal active site Cys" evidence="3">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="3">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="3">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="30"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU37023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="105" mass="12253" checksum="CC2F8B7AD318135D" modified="2009-10-13" version="1" fragment="single">MVHNVRTNEEFKEALETYDIVVVDFFATWCEPCKVIAPVYAHCHELDKFKDFRFLKINVDELPDLCEELKVSSMPTFQLYKKGEKIDELQGADREGLIKLLEKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZH63</accession>
    <name>C7ZH63_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_51736</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698927">
        <property type="protein sequence ID" value="EEU36675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042388.1">
        <property type="nucleotide sequence ID" value="XM_003042342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZH63"/>
    <dbReference type="GeneID" id="9669396"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51736"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51736"/>
    <dbReference type="eggNOG" id="ENOG502RW31">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_12_0_1"/>
    <dbReference type="InParanoid" id="C7ZH63"/>
    <dbReference type="OMA" id="AMRIYTK"/>
    <dbReference type="OrthoDB" id="5342292at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF124">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="54"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="307"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU36675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="387" mass="43206" checksum="49842299043A9207" modified="2009-10-13" version="1">MTTFPTINGTEVFRLPPPGYGPLDFDNPRQQKKLEHYLIFGLGAPLALIALLQRYYTKIFLSKGLQTDDGKLQESESRSLDSPNLSFIASIAQGGMCAHSWEMSLADFQRYSLISYLCGPIYQLCNGFIKLSLLSLYLHLSPQRWFRIAVWLTIGIVTAYTIIITFMMWFLCNPPRKAFDFKVEGGSCTDAAILYMATAVSNIVTDVILFVLPIPMVYNLHMPKIQKFGAIIVFAIGSLTVATSVTRLVYLPVVLASTDVSWDSAPANIWTFIEANLFVICGSMPTLRKFFKHFMPRIVGSSGASHYGTTSYGQHQQSNTLSRVRKGRSQYAQFPEDNATELERFSDDDNKNGGTVVVGNASTEGLRDDHSERAILQTQTFTVQYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHT7</accession>
    <name>C7ZHT7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_42374</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698928">
        <property type="protein sequence ID" value="EEU36571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042284.1">
        <property type="nucleotide sequence ID" value="XM_003042238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHT7"/>
    <dbReference type="STRING" id="660122.C7ZHT7"/>
    <dbReference type="GeneID" id="9669389"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_42374"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_42374"/>
    <dbReference type="eggNOG" id="KOG0022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_14_1_1"/>
    <dbReference type="InParanoid" id="C7ZHT7"/>
    <dbReference type="OMA" id="INFMGEP"/>
    <dbReference type="OrthoDB" id="1560166at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08278">
        <property type="entry name" value="benzyl_alcohol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350:SF2">
        <property type="entry name" value="GROES-LIKE ZINC-BINDING ALCOHOL DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350">
        <property type="entry name" value="NAD-DEPENDENT ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="8">
        <location>
            <begin position="35"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="7">
        <location>
            <begin position="209"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU36571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="39585" checksum="812F6592D14AAAE9" modified="2009-10-13" version="1">MAADHNTVTRAVVCRGPLSEGKWAIELLTLQPLKETDLKVKVLSVGLCHTDLTIGSTPQELGAYPGVLGHEGCGIVLDIGSKVTAAKVGDRVLLSFRSCKSCTFCNKGEPSYCSTFTPLNMGLGSHPRTFATDKEGLPVKGFFFGQSSFCEITTVSETSVVNVSDHVQTDDDLKLLSPLGCGLQTGAGAIMKLQDLNEDDSVAIVGLGAASKIRGIKTVIAIDRVQSRLDLAKHFGATHTLDSSRLGNELVPAVQGLTEGLGASVSVDATGNLNVIKQGIVATRNLGKVCMLGVTPPGTTLDIDSTSFLGSGKQLFGSVEGGVIPTEFIPSLIQWHRQGILPIERIVKFYPAESFAQALSDMRSGDVVKPVLYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZI08</accession>
    <name>C7ZI08_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Lariat debranching enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_52551</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lariat debranching enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698929">
        <property type="protein sequence ID" value="EEU36375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042088.1">
        <property type="nucleotide sequence ID" value="XM_003042042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZI08"/>
    <dbReference type="FunCoup" id="C7ZI08">
        <property type="interactions" value="676"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZI08"/>
    <dbReference type="GeneID" id="9674424"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_52551"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_52551"/>
    <dbReference type="eggNOG" id="KOG2863">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005893_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZI08"/>
    <dbReference type="OMA" id="DWPNGVE"/>
    <dbReference type="OrthoDB" id="407609at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008419">
        <property type="term" value="F:RNA lariat debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00844">
        <property type="entry name" value="MPP_Dbr1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007708">
        <property type="entry name" value="DBR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041816">
        <property type="entry name" value="Dbr1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849:SF0">
        <property type="entry name" value="LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849">
        <property type="entry name" value="RNA LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05011">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01124">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lariat debranching enzyme C-terminal" evidence="13">
        <location>
            <begin position="263"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU36375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="431" mass="48680" checksum="D778B5D1A85D2A5A" modified="2009-10-13" version="1" fragment="single">QGHGELDTIYATLENQCEAKGWALSEIDFLIICGDFQAVRNDLDLNCMSVPRRYLRMGDFHKYYSGAAKAPVLTLVIGGNHEASNYLFELYHGGWLAPNIYYLGAAGVINYGPCRIAGLSGIYNGSDYRKSHDERLPYDRDLIRSIYHVREYDVQKLLQVTQPVDIALSHDWPTWVELFGNHEQLFAEKPHFFASAKVDNLGSKPAAEVLNGLRPSYWFSGHMHARFEATVEHRGSKMEDSVKQLDLPDTLKDVLPLFKSRRKPSQASSSESVGRNQQTEFLALSKAGQDVASYMELKELKVPTLLTGSALTETSNGGKFHLCYDAEWLAITRAYNDTLRIPDPETLIVPPLKGKQKSPASTIPKHKDWVKENIVDKDLLRIPNNFARHAPEYDPNVGQRREQPLEYPNQQTAEFAKLLGISNKFHLEDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKK6</accession>
    <name>C7ZKK6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_86188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698940">
        <property type="protein sequence ID" value="EEU35425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041138.1">
        <property type="nucleotide sequence ID" value="XM_003041092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKK6"/>
    <dbReference type="GeneID" id="9675820"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86188"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86188"/>
    <dbReference type="eggNOG" id="ENOG502RB4F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024934_0_3_1"/>
    <dbReference type="InParanoid" id="C7ZKK6"/>
    <dbReference type="OMA" id="PEMACSH"/>
    <dbReference type="OrthoDB" id="3546279at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="33797" checksum="B12C9DE48A995AD5" modified="2009-10-13" version="1">MSSILTQEPATEDVWRKVVPEIAFSHDFLMHGMLGLSAMHYAQSHPDQRREYTLISSHYQSLAVQNFATKLQDINEDNFEPYFFLATFVFILSMCSIADRQDSGLPAPRDIAQSFILLQGIKSICEFKPMETWSRDGPLAPLLEQHEPLPVKRTGAFQNRMEKLYGLARELSPTFSVINVQSSCLLAIESLRTTHTACTTDTMSARARRIWLWPMSLTQVFIELISNNHHVALIILAHYAALTRPFEHPHWMNREWSGNVMAAVECALDERWHEWIAWPKKALLEQIDVDEMDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKM0</accession>
    <name>C7ZKM0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_51160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698940">
        <property type="protein sequence ID" value="EEU35463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041176.1">
        <property type="nucleotide sequence ID" value="XM_003041130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKM0"/>
    <dbReference type="GeneID" id="9675706"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51160"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51160"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006937_8_1_1"/>
    <dbReference type="InParanoid" id="C7ZKM0"/>
    <dbReference type="OMA" id="SMPNMFM"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF5">
        <property type="entry name" value="DUAL-FUNCTIONAL MONOOXYGENASE_METHYLTRANSFERASE PSOF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU35463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="530" mass="59914" checksum="E6E9C10B91D0A33D" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKS4</accession>
    <name>C7ZKS4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SGTA homodimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_61659</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SGT family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698941">
        <property type="protein sequence ID" value="EEU35347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041060.1">
        <property type="nucleotide sequence ID" value="XM_003041014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKS4"/>
    <dbReference type="FunCoup" id="C7ZKS4">
        <property type="interactions" value="600"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZKS4"/>
    <dbReference type="GeneID" id="9675655"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_61659"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_61659"/>
    <dbReference type="eggNOG" id="KOG0553">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044224_1_1_1"/>
    <dbReference type="InParanoid" id="C7ZKS4"/>
    <dbReference type="OMA" id="DMARNMM"/>
    <dbReference type="OrthoDB" id="2335338at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.420:FF:000005">
        <property type="entry name" value="Hsc70 cochaperone (SGT), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000207">
        <property type="entry name" value="Small glutamine-rich tetratricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000011">
        <property type="entry name" value="TPR Domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047150">
        <property type="entry name" value="SGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032374">
        <property type="entry name" value="SGTA_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831:SF2">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16546">
        <property type="entry name" value="SGTA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="SGTA homodimerisation" evidence="7">
        <location>
            <begin position="7"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="103"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU35347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="361" mass="37058" checksum="D4BE624FC98B0010" modified="2009-10-13" version="1">MASTHTSKQRLALAICDFLSASTNDGTLTADDKDSIDVAVNCIAESFKIDPTDTSAVAAAVGSQNLLQIYSVFEKARADKPAAAATASTPSAPEPTEEQKKESEGLKSKGNAAMAQKNYGLAIDLYTQALGLNPVNAVFLSNRAAAHSANKDHASARADAEAAVSIDPGYTKAWSRLGLARFALGDARGAMEAYARGIEHEGNGGSDAMKKGYETAKRRVQEMEAEEDSLNRSAPSVGVDVNANPGMPDLGNLASMFGGAGGPGGAGGGMPDLGSIMSNPMFANMAQKLMSNPDLMNNLMSNPRLREMADRYSTGGGMPDLNSLMSDPQIGEMARSMMGGGAPGAGGNPFGGAGGQGGAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLC2</accession>
    <name>C7ZLC2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_72912</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698944">
        <property type="protein sequence ID" value="EEU35213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040926.1">
        <property type="nucleotide sequence ID" value="XM_003040880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLC2"/>
    <dbReference type="GeneID" id="9675256"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_72912"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_72912"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_6_3_1"/>
    <dbReference type="InParanoid" id="C7ZLC2"/>
    <dbReference type="OMA" id="NNTWNRG"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="179"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU35213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="347" mass="38918" checksum="3C454817000D1FB5" modified="2009-10-13" version="1">MAQLEIPIIDFSGFYSEDPTRKQAVVDQVRQSCLYNGFFQITGHSVPLQQQKQALACAKKFFSLSQAEKDEVSKDKTTWNRGYEMLRSQILEEGTQPELKEGFYIGDDIPKTHPYFVNKKLNSGPNQWPEALGDDLTDFKNHSMEYYHSTLKLASDLMRVLALSLDLEETYFSRFLDGAVATMRLLHYPSQPADADEKLTRGIGAHTDFGAITMLLQDKVDGLQVWDQKNNVWIDVPPTEGALVVNLGNLMARWTNEKYKSNVHRVINKSGNERYSIPVFVSGNPDYVVDCIPTCKAAQDPAKFEPATVEQVVSASYAESYGRAQLYKQGLQKTIDSQVKPAGVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLF7</accession>
    <name>C7ZLF7_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_72896</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698944">
        <property type="protein sequence ID" value="EEU35153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040866.1">
        <property type="nucleotide sequence ID" value="XM_003040820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLF7"/>
    <dbReference type="GeneID" id="9675232"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_72896"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_72896"/>
    <dbReference type="eggNOG" id="KOG1237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004790_4_2_1"/>
    <dbReference type="InParanoid" id="C7ZLF7"/>
    <dbReference type="OMA" id="ACQICLA"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="534"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU35153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="560" mass="60157" checksum="F0A2ACF25630B5F5" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLP5</accession>
    <name>C7ZLP5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Linalool dehydratase/isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_82460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698946">
        <property type="protein sequence ID" value="EEU35065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040778.1">
        <property type="nucleotide sequence ID" value="XM_003040732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLP5"/>
    <dbReference type="STRING" id="660122.C7ZLP5"/>
    <dbReference type="GeneID" id="9679214"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82460"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82460"/>
    <dbReference type="eggNOG" id="ENOG502QYCV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027581_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZLP5"/>
    <dbReference type="OMA" id="WGYWATE"/>
    <dbReference type="OrthoDB" id="9979195at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041411">
        <property type="entry name" value="Ldi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18566">
        <property type="entry name" value="Ldi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Linalool dehydratase/isomerase" evidence="2">
        <location>
            <begin position="283"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU35065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="705" mass="78146" checksum="9C879B804D31EA7A" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLR9</accession>
    <name>C7ZLR9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAM1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Outer kinetochore protein DAM1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">NECHADRAFT_9895</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698947">
        <property type="protein sequence ID" value="EEU35007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040720.1">
        <property type="nucleotide sequence ID" value="XM_003040674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLR9"/>
    <dbReference type="STRING" id="660122.C7ZLR9"/>
    <dbReference type="GeneID" id="9679166"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_9895"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_9895"/>
    <dbReference type="eggNOG" id="ENOG502S08R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083960_2_1_1"/>
    <dbReference type="InParanoid" id="C7ZLR9"/>
    <dbReference type="OMA" id="PNSRSWT"/>
    <dbReference type="OrthoDB" id="5586015at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990537">
        <property type="term" value="C:mitotic spindle polar microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013962">
        <property type="entry name" value="DASH_Dam1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08653">
        <property type="entry name" value="DASH_Dam1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEU35007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="85" mass="9459" checksum="C435E78BC2E0F82F" modified="2009-10-13" version="1" fragment="single">PTTPLRPSSRSSFRESARGAGENDAPFPLNAFEPAFAELSDAMADLEANMMHFQLMHESLARFSESFASFMYGLNMNAFCVDFPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZM12</accession>
    <name>C7ZM12_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_78548</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698948">
        <property type="protein sequence ID" value="EEU34995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040708.1">
        <property type="nucleotide sequence ID" value="XM_003040662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZM12"/>
    <dbReference type="STRING" id="660122.C7ZM12"/>
    <dbReference type="GeneID" id="9679131"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78548"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78548"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_27_0_1"/>
    <dbReference type="InParanoid" id="C7ZM12"/>
    <dbReference type="OMA" id="RNHCPYP"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF17">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0349">Heme</keyword>
    <keyword evidence="8 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU34995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="57130" checksum="C510961C2A480864" modified="2009-10-13" version="1">MQLTLTLLPVALAAAVAYFIAFQVTVYRRRRSHGCKPAPHAMAWDPIFGLKHATALHKAIRNHRNLEYFDKMFKSYGNTFEVGLLGNLMHVTCDPENIKAILATKFADWDMGPRRRWATFEFVGVGIFAADGQDWVHARTAARPQLARSYFADTAVWEKHLQIWFESLRGQNPPGSLVELQEWTQRFMVDVGTEMLSGRPLDVLTEERAHVGRRFLWALDRANTMISERLRAGKMSFLVRDGQLQEARRVLHEGVDPFVMEAIRDHKEGSYVEDDNKYTVPRALAAEGVPLEQIRDHVLNLLLAAVGSEASLISTLFFVLARYPEVQEKLRQEMSNTLEGDRMPTYDDVRNMKYLNWVIKEVLRVYPPVPQNLRVANKDTILPVGGGPDGRSPVFIPKGHECSFSSYSLHRREDLWGKDSLDFRPERWEKERPTWSYIPFSGGPRICLGQQLALVGAGYVLLRFMQQYPTFKGPQPIQEWEEKLNITCFVNNGVWVNIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMR7</accession>
    <name>C7ZMR7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxymethylenebutenolidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_44627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698958">
        <property type="protein sequence ID" value="EEU34683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040396.1">
        <property type="nucleotide sequence ID" value="XM_003040350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMR7"/>
    <dbReference type="STRING" id="660122.C7ZMR7"/>
    <dbReference type="GeneID" id="9678809"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_44627"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_44627"/>
    <dbReference type="eggNOG" id="ENOG502QWD6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032662_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZMR7"/>
    <dbReference type="OMA" id="PSNQMFE"/>
    <dbReference type="OrthoDB" id="5440at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436:SF3">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="POLYKETIDE CYCLASE SNOAL-LIKE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="44391" checksum="EA6D6589EA9E8DC8" modified="2009-10-13" version="1">MPVYADITKPPARLPQPKPQSLGEGITLLPPLSRLGRGPGLIILTEESEKHLQIIEGVPSALIKWAEEGYAVVEIQGKAFSRGVEEVVGVALEGLSNCDKLEPKNSKVGVIAYDPKLWSQASGALLGSPNVVGGVVYASASDEDQVEASGVPVLRHVAGSSAITKKENGVTTYPYANGKSFRMATPFDKDFDYWAESLSHTRNLTFLKPLMGGPYFDLEQIWDEHTYYEFADRSVEHTMSTMVDQPYVNHVPTFYRGHFIFQNSVDTELELISRTMGIDRVVDEFIYKFTHDATVDWLLPGVPPTFKKLEMPFTAVVNIRGDRLYHEHISWDQGTVLAQLGLMPQYLPFPYPVKGQKEGSRFEFRVPVLGIETASKMRDRNSVPSNEMFDYTVREVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZN02</accession>
    <name>C7ZN02_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_3907</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698960">
        <property type="protein sequence ID" value="EEU34623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040336.1">
        <property type="nucleotide sequence ID" value="XM_003040290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZN02"/>
    <dbReference type="GeneID" id="9678736"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_3907"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_3907"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_4_0_1"/>
    <dbReference type="InParanoid" id="C7ZN02"/>
    <dbReference type="OMA" id="EICREDA"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF15">
        <property type="entry name" value="TRANSPORTER SEO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU34623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="48642" checksum="B182FD08B9FCC379" modified="2009-10-13" version="1" fragment="single">WFDPNDSPAERRLVQKLDFFILTYAFVGFWVCSAQVHVTRPILALTSTQVLYIDRGVLANAYVSGMREELELFGNQYIQLNAVYSAGYCISMIPATLLITKYKAQLVIPACMFMWGIWSICCFQAKSFRELIAYRFLMALSQGPYFCSIHYILGSWYRTDEIIRRAGIFYVSSGVGTMTTGLLAARIYTNLDGHLGHAGWRWMYLVASFLTFPVAIWGLTSLPGTPRDGKRWFMTEHEFGLAKERMALQGRLDPKGLSLSKESLKRFLGRWHFWVLVPWNVQWTLGFLGMSSGALWLRAQTQYTTAQVNNFTAISPSLGIIWIMSFAWVVDKFGRKAIIPTIAFAFRKLFISKMHVTNLALPRFAIVVNYIEVSLSPINYSLANIVCAADAEERAFVISSMLAISTAFGAWVSILSFPTVEAPRFFKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZN40</accession>
    <name>C7ZN40_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_88856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698962">
        <property type="protein sequence ID" value="EEU34555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040268.1">
        <property type="nucleotide sequence ID" value="XM_003040222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZN40"/>
    <dbReference type="GeneID" id="9678702"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88856"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88856"/>
    <dbReference type="HOGENOM" id="CLU_1578941_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZN40"/>
    <dbReference type="OrthoDB" id="10586612at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="169" mass="19211" checksum="6E8267B2C4C4B717" modified="2009-10-13" version="1">MPALTVEQRVHLRAQVEERNSDQDSVSSGLSTMGVAESRLTSLSQPKLIGNTIQRGTREHRQTRQASALAESPGESVGPKKETESLFNHWPPYNDSVRAVEMPTITPPSPLRIETPIQQRHNSLEDVLPEPSRDPVLTHGNLERFEDLRKKATNTKWMRDARRQLWDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZN53</accession>
    <name>C7ZN53_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_88869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698962">
        <property type="protein sequence ID" value="EEU34561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040274.1">
        <property type="nucleotide sequence ID" value="XM_003040228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZN53"/>
    <dbReference type="GeneID" id="9678095"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88869"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88869"/>
    <dbReference type="eggNOG" id="ENOG502SEAR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032064_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZN53"/>
    <dbReference type="OMA" id="CKTPGER"/>
    <dbReference type="OrthoDB" id="4630416at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="493" mass="55627" checksum="D828DA1DC601B89B" modified="2009-10-13" version="1">MLGPRPTPPVVQRDGFQLRQGHFTRINGDIGRVSGSRLKELFDPSSLQLEQDRIEAERTAQQLFTKKFFSAQLSHYGLRHPRNIKNPNSGHFRELLREAVLNGKCDQVPERVTNLKHAMELELEPIHQQWVIDVEAWEATKRQEEEEALHNKSPGEKANIDVNWFMDYYFLTNGKPDRTKTSEPLALHGYSDLGRNICALVDRVPGLAWARSGTRFETTLCIGWGHKAVQALAEKLTAEAWAARRKREKTDRENAMNAHQDYLSQSNQGGSSRDRPARAANQSPQTLFDLGQCRGSYVVESNTLLGAWEEMVEEVGCGSTATRPLFTLDIRDSKVAGILIAAVDFGTFQGAMILSDSKRKLRDLLRSEGETDEFSDRDYDGEYGTEDDEDEEDDEDDESDIADDEDWESDPPRKRQKTTPSASRRIFFRTPGCDAGEYYSDPQPGYLDFSNDGYASFCGQCLLAEEADVDLKGYKVSDVPAPAKRGGDFEWPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZND0</accession>
    <name>C7ZND0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_98184</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698966">
        <property type="protein sequence ID" value="EEU34479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040192.1">
        <property type="nucleotide sequence ID" value="XM_003040146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZND0"/>
    <dbReference type="STRING" id="660122.C7ZND0"/>
    <dbReference type="GeneID" id="9678014"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_98184"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98184"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_3_1"/>
    <dbReference type="InParanoid" id="C7ZND0"/>
    <dbReference type="OMA" id="DFACKIH"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08282">
        <property type="entry name" value="PFDH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF3">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT FORMALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="9">
        <location>
            <begin position="32"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="8">
        <location>
            <begin position="164"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU34479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="356" mass="38081" checksum="B14851A3F6A9E707" modified="2009-10-13" version="1">MSLNASMRAVLWEGVPLEMNVASVPVPVIREPTDALVRITASALCGTDLHTYHGLFGSPNVPWIMGHEGMGYVERVGDAVSALTVGDLVVVPSQASIGHLAMGPALPEGFGLGTTYGDGGGCQSDTVDDIEYLFLSDIFPTGWAALDFANFEPGDTVAVFGAGPVGLLAAYSAILRGATKVYSVDYVQERLDLAASIGAIPINFRESDPVQQILAHEPDGVIRSLDCVGAEALNNQLERQQNIILNQMIEVTRARGGIGIVGEHSTVGNDTAGAPLGSTLEPIYEFPFSQLYMKSLSLRGGSVDPKLYAAQLAEIIQNGKARPSFIISALIDMEEVPQYYQLFDQRQEVKVVIRFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZP96</accession>
    <name>C7ZP96_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium uniporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">NECHADRAFT_96683</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Highly selective calcium channel localized to the inner mitochondrial membrane, which mediates calcium uptake into the mitochondrial matrix. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates ATP production, cytoplasmic calcium signals and activation of cell death pathways. Sufficient to operate as a pore-forming channel without the need of calcium-sensor or auxiliary subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="17">Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer, assembles in a dimer or dimers configuration with two interfaces.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Mitochondrion inner membrane</location>
            <topology evidence="1 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the MCU (TC 1.A.77) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040022.1">
        <property type="nucleotide sequence ID" value="XM_003039976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZP96"/>
    <dbReference type="STRING" id="660122.C7ZP96"/>
    <dbReference type="GeneID" id="9677661"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_96683"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_96683"/>
    <dbReference type="eggNOG" id="KOG2966">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035826_1_1_1"/>
    <dbReference type="InParanoid" id="C7ZP96"/>
    <dbReference type="OMA" id="IKHECDA"/>
    <dbReference type="OrthoDB" id="278338at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015292">
        <property type="term" value="F:uniporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006769">
        <property type="entry name" value="MCU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039055">
        <property type="entry name" value="MCU_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462:SF10">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04678">
        <property type="entry name" value="MCU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 17" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4 17" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 17" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium uniporter protein C-terminal" evidence="19">
        <location>
            <begin position="279"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="48"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="198"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="442"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU367035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EEU34309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="459" mass="52730" checksum="E902A977EEBEFE06" modified="2009-10-13" version="1">MNHALRRATLRLSPALRTRLPTQTFSPAFCRCETLQKPFTRTFTTSKYTQQEQAARDEDLSDRAQKRQVRKVTSGTSAQTLENDRPWHRMDSQAETGAGEEDLPKKEDMTKGRLLTTPTRLLKLILPMPFHPEQEHVNRPVGGEDVKDADDTVEPLALLVHPQQPLSYLERLIQAEIPPVQYKGREKLPDIVFRAEADQEEQHGKKDDNKNGANVASYSGLGHEGPSRKEANWVRWSGSTEVGDFIRDAARGREFAIDIEGYSNELRVAVPSFRDRTYYMRMRLRRMSRDIDTMAKVKNECDALAHQGAHRLAQGGFAALAGWWGVVYYVTFHTQWGWDLVEPVTYLAGLSTIMGGYLWFLYISKDLSYKAAMRVTVSKRQTALYQERGFNQQRWEQVVHEANTLRNEIKVVASEYDVDWDENKDLGGEEVKKVLEEEEKATRKRQKRSRRSSKRVLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPE4</accession>
    <name>C7ZPE4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_96708</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039842.1">
        <property type="nucleotide sequence ID" value="XM_003039796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZPE4"/>
    <dbReference type="STRING" id="660122.C7ZPE4"/>
    <dbReference type="GeneID" id="9677570"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_96708"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_96708"/>
    <dbReference type="eggNOG" id="KOG0069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZPE4"/>
    <dbReference type="OMA" id="CADRTKE"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333">
        <property type="entry name" value="2-HACID_DH_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="3">
        <location>
            <begin position="133"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="3">
        <location>
            <begin position="207"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU34129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="335" mass="37241" checksum="90966C3F280D258F" modified="2009-10-13" version="1">MSSSEVLLVITPFAPKPEWLANLKAKCPSVEVITHPTELYAQEVPKEKAFPPKEWMPNLQFAQLLSAGCAQIFGLPLFEETEIAFSTSNDSHAPQVSEWVIGTWMAHQHFCSQSLTTSTFKSRANGWTLTRMKTPRILGILGYGNIGRQVAKIATTLGMDVHAYTLHERATAESRKDDGFVETGLGDPDGLLPSKWFHGKDQLNDFLASDLDLLVILLPLTEQTRNMISKEQFALLSKKKTYVCNTGRGPIVNTGDLITALDTEQIRGAALDVTDPEPLPSDSKLRGYKNAIITPHCAGNSNHVYERVFKILTYNLERRSKGEQPINKVRKSLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPM0</accession>
    <name>C7ZPM0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_9901</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040088.1">
        <property type="nucleotide sequence ID" value="XM_003040042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZPM0"/>
    <dbReference type="FunCoup" id="C7ZPM0">
        <property type="interactions" value="972"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZPM0"/>
    <dbReference type="GeneID" id="9677828"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_9901"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_9901"/>
    <dbReference type="eggNOG" id="KOG0003">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010412_6_2_1"/>
    <dbReference type="InParanoid" id="C7ZPM0"/>
    <dbReference type="OMA" id="AMKYNCE"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000014">
        <property type="entry name" value="Ubiquitin-60S ribosomal L40 fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU34375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="80" mass="8965" checksum="8FE02E4885448A7B" modified="2009-10-13" version="1" fragment="single">FVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGIIEPSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPM3</accession>
    <name>C7ZPM3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_85766</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS52 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039879.1">
        <property type="nucleotide sequence ID" value="XM_003039833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZPM3"/>
    <dbReference type="FunCoup" id="C7ZPM3">
        <property type="interactions" value="892"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZPM3"/>
    <dbReference type="GeneID" id="9677831"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85766"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85766"/>
    <dbReference type="eggNOG" id="KOG1961">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010797_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZPM3"/>
    <dbReference type="OMA" id="IHVVMVE"/>
    <dbReference type="OrthoDB" id="19482at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007258">
        <property type="entry name" value="Vps52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048361">
        <property type="entry name" value="Vps52_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048319">
        <property type="entry name" value="Vps52_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190">
        <property type="entry name" value="SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190:SF7">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20655">
        <property type="entry name" value="Vps52_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04129">
        <property type="entry name" value="Vps52_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps52 coiled-coil" evidence="7">
        <location>
            <begin position="158"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Vps52 C-terminal" evidence="8">
        <location>
            <begin position="344"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU34166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="665" mass="74291" checksum="CA7994F21AE34327" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQ74</accession>
    <name>C7ZQ74_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_15651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698984">
        <property type="protein sequence ID" value="EEU33842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039555.1">
        <property type="nucleotide sequence ID" value="XM_003039509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQ74"/>
    <dbReference type="STRING" id="660122.C7ZQ74"/>
    <dbReference type="GeneID" id="9667069"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_15651"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_15651"/>
    <dbReference type="eggNOG" id="ENOG502QRBS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022730_2_2_1"/>
    <dbReference type="InParanoid" id="C7ZQ74"/>
    <dbReference type="OMA" id="RTLEKMH"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF213">
        <property type="entry name" value="DEPENDENT OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="42"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU33842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="430" mass="47819" checksum="C53EC2D57F49CF8A" modified="2009-10-13" version="1" fragment="single">ITAQIEADPGLPQSNSTISSWQVPVHPDVGRIQSEALPQFSDYIVIGSGVAGCGVVKSLLENSSPANSSVTVLEARGLCSGATGRNGGQLVKPYPSRFVQLTQDFGVDVAVKVFRLANHTLEEMHKLASSYDDQLCEDAAARRVTKMVAFMDQESWIQGQKDAKFYEEHMPEERGLFKFFTKEQMEKEWNVKGSYGGLSFPSGVCWPYRLITGVFKRLQDQFPNRLNIETNTPVTTILYDEKADPKYPYIITTPRGIVKATHVIHCTNGHTGHLLPRLRGKIFPMREAMSAQDVGDKMPDMSDQMSWTFLEEPKFDSKTGMIRIGWVYGLQNRNNGGFWIGGEDRRPEEMIASDDSVISIQGKVDLETKLTQVFNQNWVPKQPEIQGIWTGIMASTGDTLPFVGNLPASVTGRPGKGEWIAGGWNQYGMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQI5</accession>
    <name>C7ZQI5_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_89211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698996">
        <property type="protein sequence ID" value="EEU33720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039433.1">
        <property type="nucleotide sequence ID" value="XM_003039387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQI5"/>
    <dbReference type="GeneID" id="9666961"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89211"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89211"/>
    <dbReference type="eggNOG" id="ENOG502RVJ2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1283564_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZQI5"/>
    <dbReference type="OrthoDB" id="5030973at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU33720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="215" mass="23746" checksum="D45B478416DF6A99" modified="2009-10-13" version="1">MESNYDDVDLAYQPVGNDNEALASFNLPMFINGDDNNIFHTKNASMSDWNRRICSLLEVLYSTLDDSPKSTSATLLVLKFRFATIKHRRRLVRARISIEFFSKDPEVAAPTVLAIGFDYRWAVEPTVDHDDSVAGGKMNVGVPGIPFVEATVAASTEKTRSRDRQDATTITGSTHFGKGLDTGNHTACSWTLLENKTRKNASPNQETPRANSSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQM6</accession>
    <name>C7ZQM6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_89252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699003">
        <property type="protein sequence ID" value="EEU33673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039386.1">
        <property type="nucleotide sequence ID" value="XM_003039340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQM6"/>
    <dbReference type="GeneID" id="9666916"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89252"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89252"/>
    <dbReference type="HOGENOM" id="CLU_1482383_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZQM6"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU33673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="182" mass="21101" checksum="0F8DF64E33B0DFFA" modified="2009-10-13" version="1">MAAKDEGNEGNTDLIDKDGLLDNEDLLRRLAIEDHVIADHHRVLILLRFLGAIEEERPYRRGRRRRRLRTNTRLARHLTYNVVSSLSEQYAAWREVHSVSALNLGKLAVAVRTTYYQVHSASLRNPTTMTKIVRSAGGWDMDYYSQRENLARLLAYLFHLRRTLGLFTIPRSTRGIQHMFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQY3</accession>
    <name>C7ZQY3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alcohol dehydrogenase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_56483</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG699020">
        <property type="protein sequence ID" value="EEU33570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039283.1">
        <property type="nucleotide sequence ID" value="XM_003039237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQY3"/>
    <dbReference type="STRING" id="660122.C7ZQY3"/>
    <dbReference type="GeneID" id="9666803"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_56483"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_56483"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZQY3"/>
    <dbReference type="OMA" id="HEVGPDC"/>
    <dbReference type="OrthoDB" id="5407715at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05188">
        <property type="entry name" value="MDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350">
        <property type="entry name" value="NAD-DEPENDENT ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350:SF17">
        <property type="entry name" value="NAD-DEPENDENT ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="200"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU33570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="381" mass="40748" checksum="1C8439CD8BC08788" modified="2009-10-13" version="1">MSSNSTVTKNRALWLSSFDKPLELVDLPVPEATAGSVVVKVLNTVVFPYAEDIHQGRLPVFNLSLPLVPHPSHIGRVHAVGSDAVLAKPGDLVFFSAPIFARDDPDVNIIQGHHGGEGPRGRRLMQGEWRDGALQEYQKVPLENIFILNEDRLCKQLGYTPADLHEISFYTIAAGALCEAANLQAGETIALGPATGTFGGITSDMALALGANVIAIGRSEEKLAGLAKQLGNHERFSYVVMTGDDEVDAAAIRKATPDGRGVEVYNDWASGALTGSPYFSAAIRAVRPEGRVVLSGAPSGSISVPYTLVMHQNIKIIGKVIVSRGGIDLTIKMVNSGILKLGKRGGSAHKVYSLEDHHAAFQDAKKNSGFRVYTDIAPNPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>C7YGS3</accession>
    <name>C7YGS3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thymidylate synthase</fullName>
            <ecNumber evidence="4">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_31603</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="4"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054223.1">
        <property type="nucleotide sequence ID" value="XM_003054177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YGS3"/>
    <dbReference type="FunCoup" id="C7YGS3">
        <property type="interactions" value="573"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YGS3"/>
    <dbReference type="GeneID" id="9676836"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_31603"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_31603"/>
    <dbReference type="eggNOG" id="KOG0673">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021669_0_2_1"/>
    <dbReference type="InParanoid" id="C7YGS3"/>
    <dbReference type="OMA" id="AYGRFWR"/>
    <dbReference type="OrthoDB" id="766at2759"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.572.10:FF:000005">
        <property type="entry name" value="Thymidylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548:SF2">
        <property type="entry name" value="THYMIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="THYMIDYLATE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate synthase/dCMP hydroxymethylase" evidence="12">
        <location>
            <begin position="25"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU48510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="326" mass="36619" checksum="FCC54CEC275C23A8" modified="2009-10-13" version="1">MTASQTPSTGKPSNGSSSSVNREEHQYLDLVKEILETGERRPDRTGTGTYSIFAPRPLKFALNNNGTPILPLLTTKRVFTRAVIAELLWFVEGNTSSTSLSEAGIKIWDGNGSREFLDNLGLNHREVGDLGPVYGFQWRHFGAEYVDAKTDYTGQGVDQLAEIIHKLRTNPYDRRLILSAWNPADLKKMVLPPCHMFAQFYVSYPRRKDGDPETKPQGHLHCQLYQRSCDMGLGVPFNIASYALLTHMMAHVCELVPGSLTHVMGDAHVYLDHVEALNTQLEREPRDFPELEITREKGGSIDGWKAEDFVIKGYDPHKTIAMKMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHC5</accession>
    <name>C7YHC5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytosolic Fe-S cluster assembly factor NAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Cytosolic Fe-S cluster assembly factor nar1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Nuclear architecture-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_90148</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the cytosolic Fe/S protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. May play a role in the transfer of pre-assembled Fe/S clusters to target apoproteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NARF family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053608.1">
        <property type="nucleotide sequence ID" value="XM_003053562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YHC5"/>
    <dbReference type="FunCoup" id="C7YHC5">
        <property type="interactions" value="380"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YHC5"/>
    <dbReference type="GeneID" id="9664477"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90148"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90148"/>
    <dbReference type="eggNOG" id="KOG2439">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018240_0_1_1"/>
    <dbReference type="InParanoid" id="C7YHC5"/>
    <dbReference type="OMA" id="GYLHHVL"/>
    <dbReference type="OrthoDB" id="10253113at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000042">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor NAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1780:FF:000004">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor nar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.950.10">
        <property type="entry name" value="Fe-only Hydrogenase (Larger Subunit), Chain L, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050340">
        <property type="entry name" value="Cytosolic_Fe-S_CAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11615">
        <property type="entry name" value="NITRATE, FORMATE, IRON DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="Fe-only hydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron hydrogenase large subunit C-terminal" evidence="10">
        <location>
            <begin position="120"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU47895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="577" mass="61656" checksum="2EDC245CB876F832" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C7YI03</accession>
    <name>C7YI03_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="4">2.5.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diphthamide biosynthesis protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Diphtheria toxin resistance protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">NECHADRAFT_65768</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 18">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="4"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053720.1">
        <property type="nucleotide sequence ID" value="XM_003053674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YI03"/>
    <dbReference type="FunCoup" id="C7YI03">
        <property type="interactions" value="638"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YI03"/>
    <dbReference type="GeneID" id="9674743"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_65768"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_65768"/>
    <dbReference type="eggNOG" id="KOG2648">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037146_1_1_1"/>
    <dbReference type="InParanoid" id="C7YI03"/>
    <dbReference type="OMA" id="PGQVLGC"/>
    <dbReference type="OrthoDB" id="1649088at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120513">
        <property type="term" value="C:2-(3-amino-3-carboxypropyl)histidine synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11850:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEU48007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="461" mass="50300" checksum="A64E9654E0694BEE" modified="2009-10-13" version="1">MEEDRRQTDLGTAADIEEAQLAQASPSPAETETTPATQNGATPLKQPKKRFVGRRAAAEAAAKNGGAGVSGESGAVQTAKPRRAPRLLNQVPKEILEDPNLKAAIALLPANYNFEIPKTIHRIRSSGAKRVALQLPEGLLLFATTISDILTQFCPGIETLIMGDVTYGACCIDDYTARALGCDLLVHYAHSCLIPVDVTKIKTLYVFVDITIDASHLLASLERNFASGKTIAVVGTIQFNATIHGVRSNLERAGFRVVVPQIAPLSKGEILGCTSPRLKDEDKVDLMLYLGDGRFHLESIMIHNPSIPAYRYDPYSRKLTRETYGHDEMKSLRRTAIQGARTARKWGLILGALGRQGNPHTLGLIERRLAARGIPVVHLLLSEIFPGKLALMADVECWVQVACPRLSIDWGYAFPRPLLTPYEALVALGEREDWGEGVYPMDYYGKDGLGRTRPLEIGASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7YI71</accession>
    <name>C7YI71_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SprT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_75217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054464.1">
        <property type="nucleotide sequence ID" value="XM_003054418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YI71"/>
    <dbReference type="STRING" id="660122.C7YI71"/>
    <dbReference type="GeneID" id="9664518"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75217"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75217"/>
    <dbReference type="eggNOG" id="ENOG502RJ6T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034476_1_0_1"/>
    <dbReference type="InParanoid" id="C7YI71"/>
    <dbReference type="OMA" id="NTPMTIP"/>
    <dbReference type="OrthoDB" id="5236983at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SprT-like" evidence="2">
        <location>
            <begin position="290"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU48751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="493" mass="55430" checksum="4F0BA148D3B5DA44" modified="2009-10-13" version="1">MAFRVDDGGLSLGATGPDPYVVGGKRRVSHSDGCDGFTFGPKRKRFDDDYYEYTNIDDALALPYDDAYNNNNIPPVAGPSGHESPAYPYPFHLHHRHGYPRAHYGGVHQHADYPYGRSYSSPAEDEVPHHDDIETTPPPIHPPDLMTLNKLGFLVIRERSPPPEDHEFPSIDAGLDFGSTPEPRPAPAAAFGPAPVPEACAMERTESGLSVSSDTTQHSLASLALKAEDNGLSLLSDLAAARLVRDHVAGLGSNRRRHRRSDSRHGRILRTLINPKSRAADFPLDEDALRSIFSAANELFFFNTLAGRVAWDWSHPASAQYQAHIVGTTAVRRSPVSGFETLIVLSSPILKDTQYNRRLLISTFLHEMIHSYLFVTCGLKASHDGGHTEGFRQIADTIDNWVGRGSLRLSEMDADLEHFRERPSVAHEQHQVRSRSADDQRKVPWRCERWDGCSRHDYCEPRPRPHPDHIDWEWNDREGRRARDPRRRASPFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C7YI76</accession>
    <name>C7YI76_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_75222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053764.1">
        <property type="nucleotide sequence ID" value="XM_003053718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YI76"/>
    <dbReference type="GeneID" id="9664521"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75222"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75222"/>
    <dbReference type="HOGENOM" id="CLU_1603181_0_0_1"/>
    <dbReference type="InParanoid" id="C7YI76"/>
    <dbReference type="OrthoDB" id="10325930at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU48051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="166" mass="19147" checksum="BB989CB0239AF839" modified="2009-10-13" version="1">MATPPTDQEAYFISTCNRILETTEQILEQSAKGFECLDRLLALKLSHPNIFSEEDDAKLKAVKRESDEKKTELQDNINKTRQMFLEPSPDYFREFGPDFDPLKIEEHLNRGRQDTHEWNEKLLAAERIVRANNPQIEELQKIHSDDKDAATQTETNVEKTPTSSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJ49</accession>
    <name>C7YJ49_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_90489</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053919.1">
        <property type="nucleotide sequence ID" value="XM_003053873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJ49"/>
    <dbReference type="FunCoup" id="C7YJ49">
        <property type="interactions" value="70"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YJ49"/>
    <dbReference type="GeneID" id="9676555"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90489"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90489"/>
    <dbReference type="eggNOG" id="KOG1212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="InParanoid" id="C7YJ49"/>
    <dbReference type="OMA" id="HNSIKWV"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF2">
        <property type="entry name" value="AMIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="6">
        <location>
            <begin position="79"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="212"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU48206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="537" mass="59851" checksum="E2AB895B8836169C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJ50</accession>
    <name>C7YJ50_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_75555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054634.1">
        <property type="nucleotide sequence ID" value="XM_003054588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJ50"/>
    <dbReference type="GeneID" id="9663702"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75555"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75555"/>
    <dbReference type="eggNOG" id="ENOG502SN6V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004184_7_2_1"/>
    <dbReference type="InParanoid" id="C7YJ50"/>
    <dbReference type="OMA" id="QDDKTER"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="118"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU48921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="614" mass="70614" checksum="3F4447E4671140B4" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJI9</accession>
    <name>C7YJI9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_123282</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054695.1">
        <property type="nucleotide sequence ID" value="XM_003054649.1"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YJI9"/>
    <dbReference type="GeneID" id="9663855"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_123282"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_123282"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_31_0_1"/>
    <dbReference type="InParanoid" id="C7YJI9"/>
    <dbReference type="OMA" id="FFATMLR"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.30.70.3290">
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
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    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
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    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
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    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
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        <property type="entry name" value="Thiolase-like"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="9"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="943"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2452"/>
            <end position="2529"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="9">
        <location>
            <begin position="943"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="9">
        <location>
            <begin position="1094"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="9">
        <location>
            <position position="975"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="9">
        <location>
            <position position="1159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU48982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2530" mass="275053" checksum="85A066218343DA38" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJV5</accession>
    <name>C7YJV5_FUSV7</name>
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        <recommendedName>
            <fullName evidence="2">DUF8035 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_98623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053346.1">
        <property type="nucleotide sequence ID" value="XM_003053300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJV5"/>
    <dbReference type="STRING" id="660122.C7YJV5"/>
    <dbReference type="GeneID" id="9676695"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_98623"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98623"/>
    <dbReference type="eggNOG" id="ENOG502QQ4F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025210_0_0_1"/>
    <dbReference type="InParanoid" id="C7YJV5"/>
    <dbReference type="OMA" id="EPEFEWV"/>
    <dbReference type="OrthoDB" id="5242628at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058348">
        <property type="entry name" value="DUF8035"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26118">
        <property type="entry name" value="DUF8035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8035" evidence="2">
        <location>
            <begin position="465"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU47633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="569" mass="67385" checksum="A90E1EEBC701E7EE" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJW7</accession>
    <name>C7YJW7_FUSV7</name>
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        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_74402</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054060.1">
        <property type="nucleotide sequence ID" value="XM_003054014.1"/>
    </dbReference>
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    <dbReference type="STRING" id="660122.C7YJW7"/>
    <dbReference type="GeneID" id="9663991"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74402"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74402"/>
    <dbReference type="eggNOG" id="KOG0528">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022445_0_0_1"/>
    <dbReference type="InParanoid" id="C7YJW7"/>
    <dbReference type="OMA" id="HTAYLQG"/>
    <dbReference type="OrthoDB" id="44756at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051356">
        <property type="entry name" value="SOX/SOX-like_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789:SF2">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="209"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="209"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="111"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="269"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU48347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="501" mass="55192" checksum="8A0BA274DC76FAAB" modified="2009-10-13" version="1">MPQSAPPSPPQSSDGFLQPATFMSPARITSHPRGAMSPEQGFVGYPYPSRYSTPVREDDLSVSVYEPQTVYSQKGDISFTGYAAGHNYTSHPYRPLPEEAGYNAHVPYTPEASPPTPCPTGDSITTRSGLSIPKKSYPMGRSQAVKTGRVQKRSKVDKVKNASSILSKPLSEIAKDLPEVPVADIATFVARSTEERLSETSRNKKPGQIKRPMNAFMLYRKAYQDVAKTQCAQNNHQHVSKVCGAGWPLEPPQVRQMFDGWAKVERINHQQAHPGYKFTPSKPRKTRRDEDDVDGFSDNDSDYGGARKSRTRHVSRMSETPSITYDTVGNVADEPSMAAYHGMHAYPTPGQTHALPYGPAEPNTYDLNMRQYGGLGPAHGMVSRTPSPGNDYGLHGLDGFAGSYYTPPEPVFESAGHPPMFGEAGYDMYNGLPGEASFGHDNWVPHMGAAEQDIGFMMAGYEDTAAQDAYLRGKQEDWKVEEIDDSSQFEHWITQTEQGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJX5</accession>
    <name>C7YJX5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_74410</name>
    </gene>
    <organism evidence="9 10">
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        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053353.1">
        <property type="nucleotide sequence ID" value="XM_003053307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJX5"/>
    <dbReference type="FunCoup" id="C7YJX5">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YJX5"/>
    <dbReference type="GeneID" id="9663996"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74410"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74410"/>
    <dbReference type="eggNOG" id="KOG4455">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110781_4_0_1"/>
    <dbReference type="InParanoid" id="C7YJX5"/>
    <dbReference type="OMA" id="YPGFLFY"/>
    <dbReference type="OrthoDB" id="16510at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008504">
        <property type="entry name" value="Emc6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU47640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="119" mass="13296" checksum="455CC4A5BAFA0F8B" modified="2009-10-13" version="1">MSSSERVLQINPVVPESVIHNSKALSNLHSLTASLFGVSAGILGLESYYGFLIYFVFSFITTLLFYFLKVAPESIPKGHAPLDPSRFYRGFFDFWISGMLNGISGFVLTWTLFYGLVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7YK81</accession>
    <name>C7YK81_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_74516</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053409.1">
        <property type="nucleotide sequence ID" value="XM_003053363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YK81"/>
    <dbReference type="STRING" id="660122.C7YK81"/>
    <dbReference type="GeneID" id="9664121"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74516"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74516"/>
    <dbReference type="eggNOG" id="ENOG502SR3R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034747_0_0_1"/>
    <dbReference type="InParanoid" id="C7YK81"/>
    <dbReference type="OMA" id="CCMCGYW"/>
    <dbReference type="OrthoDB" id="74807at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21437">
        <property type="entry name" value="zf-HIT_ZNHIT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039723">
        <property type="entry name" value="Vps71/ZNHIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13093">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="5">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="122"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU47696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="265" mass="28936" checksum="384F9638D6DBC6D9" modified="2009-10-13" version="1">MNNFGVIELASAKTKSAPGWAYVPDNTIASRSTAPTNRKRARNAPGLTLSDLTARQDTKIRKEVEALDKDGGRDNTIPLPVKSGRAQGKHTPNVRKILQSQKTFGNHLDDFLAMQALAESNPALSRSNTAGANNKRSSGSRRDTPTSARQPAQDEDITMTDVNLPPVLSESSKPPPTSHAGDDDPLLMSCVPEMPSDEELRKLLSHPPLTYGEATGNWDPKYPTRVFCSVCGYWGRVRCMKCGTRVCALDCLEAHKEECVTRYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7YKC3</accession>
    <name>C7YKC3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PWWP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_74558</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054143.1">
        <property type="nucleotide sequence ID" value="XM_003054097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YKC3"/>
    <dbReference type="FunCoup" id="C7YKC3">
        <property type="interactions" value="103"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YKC3"/>
    <dbReference type="GeneID" id="9664149"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74558"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74558"/>
    <dbReference type="eggNOG" id="ENOG502S12V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019479_0_0_1"/>
    <dbReference type="InParanoid" id="C7YKC3"/>
    <dbReference type="OMA" id="WPVIVCD"/>
    <dbReference type="OrthoDB" id="62853at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="187"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="570"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU48430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="598" mass="65451" checksum="5A909132BB50460A" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLF1</accession>
    <name>C7YLF1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Intradiol ring-cleavage dioxygenases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_77509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052962.1">
        <property type="nucleotide sequence ID" value="XM_003052916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YLF1"/>
    <dbReference type="GeneID" id="9671021"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77509"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77509"/>
    <dbReference type="eggNOG" id="ENOG502QPRK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027719_1_0_1"/>
    <dbReference type="InParanoid" id="C7YLF1"/>
    <dbReference type="OMA" id="HAQVHTN"/>
    <dbReference type="OrthoDB" id="121380at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03457">
        <property type="entry name" value="intradiol_dioxygenase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF4">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002987363" description="Intradiol ring-cleavage dioxygenases domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="2">
        <location>
            <begin position="94"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU47249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="339" mass="37929" checksum="94CCF971D9ACEB0D" modified="2009-10-13" version="1">MFKATFLVFFLFGAVFSHPHKEPDAESIRAHEDARRRCGPRVAKMKRDRLALRRRDDSVDADSGDTVYRINAKAPKYNKIKDWTNILTPETSRGPYFLPRSQTLRQDIREDEPGVPLSLEIGVIDVDTCDPLDSVLVDIWHCNATGSYSSFTGLSPNTQFLDLYSEKTDNGTLDLHQGLPDLSIQWLSTDESTFLRGMWPTDKHGVTSFTTIVPGFYVQRAIHIHVQIHTNWTILSNGTLAHGSIVSTGQIFIDELLSRQLMALEPYVSHTEIERVKNADDGIYNQESATGAMTLLDTEPLDGKDYTKGVFGYITLGVQMSQIRNGSTIDALPEVPVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C7YN30</accession>
    <name>C7YN30_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_99741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052766.1">
        <property type="nucleotide sequence ID" value="XM_003052720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YN30"/>
    <dbReference type="GeneID" id="9664255"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_99741"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_99741"/>
    <dbReference type="HOGENOM" id="CLU_1230229_0_0_1"/>
    <dbReference type="InParanoid" id="C7YN30"/>
    <dbReference type="OrthoDB" id="10464988at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU47053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="225" mass="24772" checksum="2C4A4CEBDFFC5CEF" modified="2009-10-13" version="1">MCSPRQQSSNVNVPSQTQVFLARGKHNRPITAPPLPILSSIGFIAELPFTDDVPRPWNLGTLSNGWRIPGTPDLNAEEVRIRYLLIDRNNLHHRQFIHHITEPHLLTPGSPPHDGALTAALQPVRAPTRIRGPLLRPPRSLASVPPRWPHSLCISDDASGHTTDEPNDAPTEDNSYRGLPHYYRIFGGLTRQATPFSFGRSPRVPRSGSETPTGISLDAVAHCNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7YP54</accession>
    <name>C7YP54_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1917 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_67998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0696 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051498.1">
        <property type="nucleotide sequence ID" value="XM_003051452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YP54"/>
    <dbReference type="GeneID" id="9673105"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_67998"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_67998"/>
    <dbReference type="eggNOG" id="ENOG502SG47">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051869_0_1_1"/>
    <dbReference type="InParanoid" id="C7YP54"/>
    <dbReference type="OMA" id="RPIYYKC"/>
    <dbReference type="OrthoDB" id="10067381at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015034">
        <property type="entry name" value="Bles03"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977:SF1">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08939">
        <property type="entry name" value="Bles03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU45785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="33916" checksum="D4736489767C5C0D" modified="2009-10-13" version="1">MDISDDSDFYGDEETVMNLQQRVQDFDVDAWMFQQQENPGRAVPRSTLIGDTSHLHNPYAGVPYAWQLTETVDEFLVRLPPKTTELSEQTPWIFICNPYIPRMEKAMAQNQLSKGNEDEAPEEEGSRTALVIEGGHERLQIASRYIQGIPRNIPISVQEREVNKERNSAAEDILRLAHAAKVRAGKWMLFCPPAEVNDVWDIVAKATANNELGIAAKVAPKPVDEDSRRDRLICVYTTDFADKADVGRVLQKLRELRLVEARGRPIYYKPDVYTYIGISSGNIWGLKATIYSSNDIFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPB6</accession>
    <name>C7YPB6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit K</fullName>
            <shortName evidence="4">eIF3k</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">eIF-3 p25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_59834</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit K family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051982.1">
        <property type="nucleotide sequence ID" value="XM_003051936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YPB6"/>
    <dbReference type="STRING" id="660122.C7YPB6"/>
    <dbReference type="GeneID" id="9668607"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_59834"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_59834"/>
    <dbReference type="eggNOG" id="KOG3252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076723_0_1_1"/>
    <dbReference type="InParanoid" id="C7YPB6"/>
    <dbReference type="OMA" id="GDDLCAD"/>
    <dbReference type="OrthoDB" id="337745at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000389">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.250">
        <property type="entry name" value="ARM repeat, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03010">
        <property type="entry name" value="eIF3k"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009374">
        <property type="entry name" value="eIF3k"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016020">
        <property type="entry name" value="Transl_init_fac_sub12_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="44"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU46269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="232" mass="26208" checksum="44155F0B461D6D6E" modified="2009-10-13" version="1">MNGEDPPERPNEIADIINGLERYNPEAVGALETYLQDQCEGKFTDCNANRTLLKLYQLNPDRIKDEVITNILVKTMTQFPSSQFSLALHLINPSSVATGDLGEAITKLRSLNGELEGAQYARFWADLDDDMVADLIADIPDFEDLIRHRIALLVSQAFRELKLSHLESWLGLDNEEATKKFVTEVAGWSVEDDDTVKVPSNPDNEAKKAEIREDVSVEQFSRVLRRSWEDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQA7</accession>
    <name>C7YQA7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_79038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052150.1">
        <property type="nucleotide sequence ID" value="XM_003052104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQA7"/>
    <dbReference type="GeneID" id="9668932"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79038"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79038"/>
    <dbReference type="eggNOG" id="ENOG502RMGQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105498_0_0_1"/>
    <dbReference type="InParanoid" id="C7YQA7"/>
    <dbReference type="OrthoDB" id="4990480at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU46437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="22466" checksum="1EB71B3967B1D7ED" modified="2009-10-13" version="1">MTSERFSSGPLWAAKLNLRLLSISFDVVLLITLLTLIAGSSPDATTIILFGPLTCMAFAWSFIDAIYLCTRNRRGHEPVTRIKFDLVLCLAFVIASSLIGYLGTTDHAVPTLDQTTDEPHLATRALFCFGIAQVFVHSLLFVIAHQEWKASTNEFQISSTSSVDDPLPASTWTVPSPKSGPGRREIVVLRDEEEGLLADASRPSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQE3</accession>
    <name>C7YQE3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATPase inhibitor, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_102558</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Inhibits the enzyme activity of ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ATPase inhibitor family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052166.1">
        <property type="nucleotide sequence ID" value="XM_003052120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQE3"/>
    <dbReference type="STRING" id="660122.C7YQE3"/>
    <dbReference type="GeneID" id="9672636"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102558"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102558"/>
    <dbReference type="eggNOG" id="ENOG502SCJG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145563_0_1_1"/>
    <dbReference type="InParanoid" id="C7YQE3"/>
    <dbReference type="OMA" id="NQGGEHN"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007648">
        <property type="entry name" value="ATPase_inhibitor_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04568">
        <property type="entry name" value="IATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64602">
        <property type="entry name" value="F1 ATPase inhibitor, IF1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="53"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU46453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="96" mass="11099" checksum="CB4AE44BE6150297" modified="2009-10-13" version="1">MLRTTFRQTATFRPVRCFSTTPRVMTEGATGAPPKTGGPGDAFQRREKANEDYAIRQREKEKLIELKKKLQEQQQHLERLSKHIDEITKEQGGEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQL8</accession>
    <name>C7YQL8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF2428 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_104137</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the THADA family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051761.1">
        <property type="nucleotide sequence ID" value="XM_003051715.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="C7YQL8">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YQL8"/>
    <dbReference type="GeneID" id="9673581"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_104137"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_104137"/>
    <dbReference type="eggNOG" id="KOG1810">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001011_1_0_1"/>
    <dbReference type="InParanoid" id="C7YQL8"/>
    <dbReference type="OMA" id="LIMDPFD"/>
    <dbReference type="OrthoDB" id="73997at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056843">
        <property type="entry name" value="THADA-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056842">
        <property type="entry name" value="THADA-like_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019442">
        <property type="entry name" value="THADA/TRM732_DUF2428"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051954">
        <property type="entry name" value="tRNA_methyltransferase_THADA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387:SF0">
        <property type="entry name" value="DUF2428 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387">
        <property type="entry name" value="THADA/DEATH RECEPTOR INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10350">
        <property type="entry name" value="DUF2428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25150">
        <property type="entry name" value="TPR_Trm732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25151">
        <property type="entry name" value="TPR_Trm732_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26523">
        <property type="entry name" value="Trm732_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like TPR repeats region" evidence="4">
        <location>
            <begin position="232"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2428" evidence="3">
        <location>
            <begin position="669"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like C-terminal TPR repeats region" evidence="5">
        <location>
            <begin position="916"/>
            <end position="1071"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU46048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1560" mass="173943" checksum="0636659CD558FB63" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRN1</accession>
    <name>C7YRN1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Up-regulated during septation protein 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_80448</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050814.1">
        <property type="nucleotide sequence ID" value="XM_003050768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YRN1"/>
    <dbReference type="STRING" id="660122.C7YRN1"/>
    <dbReference type="GeneID" id="9667976"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_80448"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_80448"/>
    <dbReference type="eggNOG" id="ENOG502S13H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013725_0_0_1"/>
    <dbReference type="InParanoid" id="C7YRN1"/>
    <dbReference type="OMA" id="EVPMDSP"/>
    <dbReference type="OrthoDB" id="5429395at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029191">
        <property type="entry name" value="Uds1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15456">
        <property type="entry name" value="Uds1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Up-regulated during septation protein 1" evidence="3">
        <location>
            <begin position="374"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="9"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="494"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="651"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="454"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="502"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="518"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU45101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="696" mass="77047" checksum="2D15B7AA7DD478D1" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRP1</accession>
    <name>C7YRP1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosomal protein L44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_69440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051209.1">
        <property type="nucleotide sequence ID" value="XM_003051163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YRP1"/>
    <dbReference type="FunCoup" id="C7YRP1">
        <property type="interactions" value="720"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YRP1"/>
    <dbReference type="GeneID" id="9665913"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_69440"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_69440"/>
    <dbReference type="eggNOG" id="KOG3464">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114645_2_1_1"/>
    <dbReference type="InParanoid" id="C7YRP1"/>
    <dbReference type="OMA" id="CKKHTIH"/>
    <dbReference type="OrthoDB" id="2967263at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.80:FF:000001">
        <property type="entry name" value="60S ribosomal protein L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_eL44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053708">
        <property type="entry name" value="Ribosomal_LSU_eL42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36A/L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU45496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="12084" checksum="821D696EB7868EA3" modified="2009-10-13" version="1">MVNVPKTRNTYCKGKDCRKHTQHKVTQYKAGKASLFAQGKRRYDRKQSGYGGQTKPVFHKKAKTTKKVVLRLECVKCKTKLQLALKRCKHFELGGDKKTKGAALVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRW7</accession>
    <name>C7YRW7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell division control protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_100599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051249.1">
        <property type="nucleotide sequence ID" value="XM_003051203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YRW7"/>
    <dbReference type="STRING" id="660122.C7YRW7"/>
    <dbReference type="GeneID" id="9666024"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100599"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100599"/>
    <dbReference type="eggNOG" id="ENOG502S6JC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052857_0_0_1"/>
    <dbReference type="InParanoid" id="C7YRW7"/>
    <dbReference type="OMA" id="YMNILLD"/>
    <dbReference type="OrthoDB" id="5357220at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012535">
        <property type="entry name" value="Cell_div_Cdc14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08045">
        <property type="entry name" value="CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU45536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="32677" checksum="4E02080B233BDD65" modified="2009-10-13" version="1">MMESLLSLAFDNLSSYDGPKVRKGLRQVEGLLAQICLSNPRSDNSRRNRDHENNGEASPEQKDLAELSQDPAFQEFFKLQEGFEWNVAMRLIGTLDRLMAKGSDGQNDLLILNALDLIQGTLLLHPPSKSLFSREQNMNLLLDLLEPFNCPAIQCATLLTLVTALLDTPRNTRTFEGLDGLLTITSLFKSRSTAREVKLKLVEFLYFYLMPESPSIPRADQRDSVPGMLQRSPSKLAGAFNNEARRKRSGSDADDVYLTTEEKQELLSQHLSSVEELVKDLRNCAPFGGVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRY3</accession>
    <name>C7YRY3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Enoyl-CoA hydratase/isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_61301</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051257.1">
        <property type="nucleotide sequence ID" value="XM_003051211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YRY3"/>
    <dbReference type="STRING" id="660122.C7YRY3"/>
    <dbReference type="GeneID" id="9668028"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_61301"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_61301"/>
    <dbReference type="eggNOG" id="KOG1681">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_0_1"/>
    <dbReference type="InParanoid" id="C7YRY3"/>
    <dbReference type="OMA" id="QYVAHVE"/>
    <dbReference type="OrthoDB" id="14970at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051750">
        <property type="term" value="F:delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000004">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000024">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149:SF1">
        <property type="entry name" value="DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU45544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="30442" checksum="3488DF16BAB7951A" modified="2009-10-13" version="1">MSSNSPLPAYASYEHMLVSSPAPFVAHVEINRPRKLNAFSQAVWLEFGRVFEQLSHDAEVRAVVLSGAGDRAFTAGLDVQAATSDGVLNGGEQDVARKAKALRSHIEEFQASISAMEKCEKPVICVVHGISIGLAIDIACCADIRISASNTRFAVKEVDIGLAADIGTLARLPKLVGSTSWVKDVCLTARDFSAQEALSVGFVSQVHEGKEAAVQAGVALAATLASKSPVAVQGTKELLNYGRDHSVDESLRYTKVWNAAAVQSKDFSQALMSGLKKTKPRFEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7YS09</accession>
    <name>C7YS09_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">4-coumarate-CoA ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_93727</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050876.1">
        <property type="nucleotide sequence ID" value="XM_003050830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YS09"/>
    <dbReference type="STRING" id="660122.C7YS09"/>
    <dbReference type="GeneID" id="9668042"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_93727"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_93727"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="InParanoid" id="C7YS09"/>
    <dbReference type="OMA" id="CSIQQWI"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF424">
        <property type="entry name" value="ACETYL-COA SYNTHETASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="41"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="469"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU45163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="569" mass="62705" checksum="89E04626763FFB75" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSC1</accession>
    <name>C7YSC1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YCII-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_80686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050936.1">
        <property type="nucleotide sequence ID" value="XM_003050890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSC1"/>
    <dbReference type="GeneID" id="9666179"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_80686"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_80686"/>
    <dbReference type="eggNOG" id="ENOG502S8X0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110355_2_4_1"/>
    <dbReference type="InParanoid" id="C7YSC1"/>
    <dbReference type="OMA" id="ESGNWKM"/>
    <dbReference type="OrthoDB" id="5519740at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1060">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051807">
        <property type="entry name" value="Sec-metab_biosynth-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606:SF3">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII-related" evidence="1">
        <location>
            <begin position="13"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU45223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="115" mass="12910" checksum="E23E350847D81A0C" modified="2009-10-13" version="1">MQSVSVPPGKYEFLVVVPDKPGVREKRLEVRHIHFSNMLPNVENGSWKTGGALLNSVPKDDSPDSLDFMGSTLVCVAKSVEEVREQLSKDIYATSGVWDMDKIQIYPFRAAFRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSR8</accession>
    <name>C7YSR8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_41583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051404.1">
        <property type="nucleotide sequence ID" value="XM_003051358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSR8"/>
    <dbReference type="GeneID" id="9668327"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_41583"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_41583"/>
    <dbReference type="eggNOG" id="KOG1205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_8_2_1"/>
    <dbReference type="InParanoid" id="C7YSR8"/>
    <dbReference type="OMA" id="KMQISIF"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU45691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="306" mass="33192" checksum="EDEDF88EF8B9D119" modified="2009-10-13" version="1">MVFTGLAKYHKEPYPEISPKLPEVSQEGRTILITGGSDGIGLATAKAFVAASAKRIIILGRRAEKLDVAVVELVKEAASTGSPTVTEGRVCDVSDLESTASLWSSLRDDGIVVDVLVLNAAAVGAIKPLTEIGRDNILKDFDLNFRTNLDFTERLYKQEGKGAGGRKVVVGVSTLAIYLWNLVNDRPSYGPSKSAGTLILQQFARAFKPEELQVSVVHPGAVWTEGMKEAGGTEGMYKFDDVNLPAHFIVWSASPQAEFLHGRLIWANWDINELKGEAFRKQLDENPNLLTVGVEGLSESKNLPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSV9</accession>
    <name>C7YSV9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Serine protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_61473</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051431.1">
        <property type="nucleotide sequence ID" value="XM_003051385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSV9"/>
    <dbReference type="FunCoup" id="C7YSV9">
        <property type="interactions" value="345"/>
    </dbReference>
    <dbReference type="GeneID" id="9668430"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_61473"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_61473"/>
    <dbReference type="eggNOG" id="KOG1153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_1_4_1"/>
    <dbReference type="InParanoid" id="C7YSV9"/>
    <dbReference type="OMA" id="RHPDVDY"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019863">
        <property type="term" value="F:IgE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.80:FF:000006">
        <property type="entry name" value="Autophagic serine protease Alp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012226465" description="Serine protease" evidence="9">
        <location>
            <begin position="16"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="11">
        <location>
            <begin position="42"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="10">
        <location>
            <begin position="193"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU45718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="530" mass="56832" checksum="4E690700F3F3092F" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7YT01</accession>
    <name>C7YT01_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NECHADRAFT_40957</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051039.1">
        <property type="nucleotide sequence ID" value="XM_003050993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YT01"/>
    <dbReference type="STRING" id="660122.C7YT01"/>
    <dbReference type="GeneID" id="9668449"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_40957"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_40957"/>
    <dbReference type="eggNOG" id="KOG1417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027174_0_1_1"/>
    <dbReference type="InParanoid" id="C7YT01"/>
    <dbReference type="OMA" id="PGTIPHG"/>
    <dbReference type="OrthoDB" id="1689029at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07000">
        <property type="entry name" value="cupin_HGO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000034">
        <property type="entry name" value="Homogentisate 1,2-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046451">
        <property type="entry name" value="HgmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01015">
        <property type="entry name" value="hmgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF4">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="14">
        <location>
            <begin position="33"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase C-terminal" evidence="13">
        <location>
            <begin position="309"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU45326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="478" mass="53891" checksum="03A08AAE16C044DE" modified="2009-10-13" version="1">MTNQDFQKIFHWAETQKNGSIPSFETRPNDPYQYQSGFNNSFESEAVPGTIPKGQNSPRAIRFGLYAEQITASAFVAPRHVNKKAWLYRARPAVAHQGFTNLPDNPDTESNFLPTNPRVHVSPTQLAWNPFEIPNGQDQDFVDGLKTIAGSGDPTLREGLATHVFLCNKSMEKRAFVNSDGDFLIVPQQGALDIQTEFGFLYVQPGEICVIQRGQRFKVKVEGPTRGYILEIWGSNFELPELGPLGANGLANARDFLHPVAAYEVTENDPWEITYKLGGKFFQSKQRHCPFDVIAWSGNYVPYKYDLTKFVNVGSISVDHIDPSIFCVLTAKSRDPTAPLADFLIFSPRWDVASHTYRPPYYHRNCASELMGLIYGDYDGRSDEFRPGSVSFECGFVPHGVAYEQFAAASKEDPPVMRISEGSVAFMFESSRAFTITDYAWKSDQKHEHDPKMWDDLVDNFSKHKIEVDQLLARKAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7YT18</accession>
    <name>C7YT18_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_80919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051458.1">
        <property type="nucleotide sequence ID" value="XM_003051412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YT18"/>
    <dbReference type="GeneID" id="9668457"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_80919"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_80919"/>
    <dbReference type="eggNOG" id="ENOG502R7JY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002639_3_1_1"/>
    <dbReference type="InParanoid" id="C7YT18"/>
    <dbReference type="OMA" id="NACGHAR"/>
    <dbReference type="OrthoDB" id="3486565at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="190"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU45745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="661" mass="72902" checksum="517B99A00CEB22F5" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7YT72</accession>
    <name>C7YT72_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_41716</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Sterol O-acyltransferase that catalyzes the formation of stery esters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051076.1">
        <property type="nucleotide sequence ID" value="XM_003051030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YT72"/>
    <dbReference type="FunCoup" id="C7YT72">
        <property type="interactions" value="252"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YT72"/>
    <dbReference type="GeneID" id="9668584"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_41716"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_41716"/>
    <dbReference type="eggNOG" id="KOG0380">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018190_2_1_1"/>
    <dbReference type="InParanoid" id="C7YT72"/>
    <dbReference type="OMA" id="INWWYVA"/>
    <dbReference type="OrthoDB" id="10039049at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034737">
        <property type="term" value="F:ergosterol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008204">
        <property type="term" value="P:ergosterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF23">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="540"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="593"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="291"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU45363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="616" mass="71393" checksum="3D572DFAB58B0899" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7YTJ7</accession>
    <name>C7YTJ7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small acidic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_84606</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMAP family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050345.1">
        <property type="nucleotide sequence ID" value="XM_003050299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YTJ7"/>
    <dbReference type="GeneID" id="9674756"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84606"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84606"/>
    <dbReference type="eggNOG" id="ENOG502S7BH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_787755_0_0_1"/>
    <dbReference type="InParanoid" id="C7YTJ7"/>
    <dbReference type="OMA" id="QAEQWQV"/>
    <dbReference type="OrthoDB" id="10066125at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026714">
        <property type="entry name" value="SMAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028124">
        <property type="entry name" value="SMAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22175:SF0">
        <property type="entry name" value="SMALL ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22175">
        <property type="entry name" value="SMALL ACIDIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15477">
        <property type="entry name" value="SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small acidic protein-like" evidence="4">
        <location>
            <begin position="279"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="107"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="300"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU44632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="352" mass="38163" checksum="D86EFF99BD4A10E3" modified="2009-10-13" version="1">MSESTNPGPKMHPDRLKAGKAPAPKRKIDKKQIKAEKRMKKRTARAEKRAAKAAAQELEGPKPKVPPLVKGQVKMQKMKMRVEKLEREGHQKLAKAKKLAAQVQAIIDAQNTNQSESKPEDKDEDMLSISGSEAEEATSDSSADSDGGVDVSKQPTEVPPEVPADEVVMKHRRLSNAASERSHVSHVETPAETEPKKEKKSKKSKKAKEVEAEEEAVEAEADSEAEEPAVSEKKSKKAEKKRKRDSEVADETSTKKEKKKGKGKKEKEDSSADAPAEQWHVDEVEGGSARQAKFLRLLGGKKGGAGAGAPATSHASKGQSDSTKAEAEIQKQFEAGMKMKNEGGSKRRGLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C7YU72</accession>
    <name>C7YU72_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cdc23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_48805</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050463.1">
        <property type="nucleotide sequence ID" value="XM_003050417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YU72"/>
    <dbReference type="FunCoup" id="C7YU72">
        <property type="interactions" value="1061"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YU72"/>
    <dbReference type="GeneID" id="9674863"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_48805"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_48805"/>
    <dbReference type="eggNOG" id="KOG1155">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018320_2_0_1"/>
    <dbReference type="InParanoid" id="C7YU72"/>
    <dbReference type="OMA" id="ERCLYHS"/>
    <dbReference type="OrthoDB" id="10262026at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007192">
        <property type="entry name" value="APC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF10">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04049">
        <property type="entry name" value="ANAPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cdc23" evidence="9">
        <location>
            <begin position="10"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="346"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="380"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="548"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU44750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="637" mass="70904" checksum="CD17B287C0E76BCA" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7YUY7</accession>
    <name>C7YUY7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Presequence protease, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Pitrilysin metalloproteinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">NECHADRAFT_96407</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Degrades mitochondrial transit peptides after their cleavage in the intermembrane space or in the matrix, and presequence peptides; clearance of these peptides is required to keep the presequence processing machinery running. Preferentially cleaves the N-terminal side of paired basic amino acid residues. Also degrades other unstructured peptides. May function as an ATP-dependent peptidase as opposed to a metalloendopeptidase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer and homodimer; homodimerization is induced by binding of the substrate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M16 family. PreP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050201.1">
        <property type="nucleotide sequence ID" value="XM_003050155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YUY7"/>
    <dbReference type="FunCoup" id="C7YUY7">
        <property type="interactions" value="668"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YUY7"/>
    <dbReference type="GeneID" id="9674560"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_96407"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_96407"/>
    <dbReference type="eggNOG" id="KOG2019">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009165_0_0_1"/>
    <dbReference type="InParanoid" id="C7YUY7"/>
    <dbReference type="OMA" id="NYLYYIR"/>
    <dbReference type="OrthoDB" id="10250783at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000013">
        <property type="entry name" value="Mitochondrial presequence protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000009">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000011">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055130">
        <property type="entry name" value="PreP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF13">
        <property type="entry name" value="PRESEQUENCE PROTEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08367">
        <property type="entry name" value="M16C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22516">
        <property type="entry name" value="PreP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16C associated" evidence="16">
        <location>
            <begin position="480"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEU44488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1004" mass="111818" checksum="4AC53CFC9A0060BB" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVB2</accession>
    <name>C7YVB2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_96468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050664.1">
        <property type="nucleotide sequence ID" value="XM_003050618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVB2"/>
    <dbReference type="GeneID" id="9675052"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_96468"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_96468"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015676_3_1_1"/>
    <dbReference type="InParanoid" id="C7YVB2"/>
    <dbReference type="OMA" id="CMKFHVP"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF68">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU44951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="639" mass="70145" checksum="48A1B5FBAD0507A0" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVR4</accession>
    <name>C7YVR4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_89611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049756.1">
        <property type="nucleotide sequence ID" value="XM_003049710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVR4"/>
    <dbReference type="STRING" id="660122.C7YVR4"/>
    <dbReference type="GeneID" id="9677331"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89611"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89611"/>
    <dbReference type="eggNOG" id="ENOG502SGAA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_352553_0_0_1"/>
    <dbReference type="InParanoid" id="C7YVR4"/>
    <dbReference type="OMA" id="MWRRHER"/>
    <dbReference type="OrthoDB" id="1918685at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="408"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="914"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU44043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="933" mass="105188" checksum="F1F5A41955404E24" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7YW01</accession>
    <name>C7YW01_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_29856</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049802.1">
        <property type="nucleotide sequence ID" value="XM_003049756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YW01"/>
    <dbReference type="STRING" id="660122.C7YW01"/>
    <dbReference type="GeneID" id="9677377"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_29856"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_29856"/>
    <dbReference type="eggNOG" id="ENOG502SZS5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103429_0_0_1"/>
    <dbReference type="InParanoid" id="C7YW01"/>
    <dbReference type="OMA" id="SQHQACN"/>
    <dbReference type="OrthoDB" id="2328572at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU44089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="211" mass="22741" checksum="3526E97B0928247C" modified="2009-10-13" version="1">MFGTWKYDPETDEVQSVRNGFDPVTARSSSHQACDRCHEKKLRCSGDKNGCERCRNNNLRCEYTRTGSKSSRRGKSSRKSAEGDSPSSSSSKRGGSSSKRSGKHHSGSSRAAASAEEGDGVLGQFDFSTLGPEDGFDLSMLSSAGADHGAGYATAGPSAGQYAQNFDGSYQQWDPAAYAAAYGQQQGYSGEDWGQYDQGDYAQDPRYYQGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXR1</accession>
    <name>C7YXR1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_45556</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049102.1">
        <property type="nucleotide sequence ID" value="XM_003049056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXR1"/>
    <dbReference type="FunCoup" id="C7YXR1">
        <property type="interactions" value="97"/>
    </dbReference>
    <dbReference type="GeneID" id="9676994"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45556"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45556"/>
    <dbReference type="eggNOG" id="KOG4510">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032828_4_3_1"/>
    <dbReference type="InParanoid" id="C7YXR1"/>
    <dbReference type="OMA" id="QIIFIRM"/>
    <dbReference type="OrthoDB" id="306876at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="63"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="252"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU43389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="400" mass="42892" checksum="FFC8B61665314FC8" modified="2009-10-13" version="1">MSYGTIKTPAPASNPPEASPLLIANGGPAASNDALDCPETSQQESLNGNSLWVTLKSIYNNNIGLFLVFLAQMFGSIMTMTTRLLETGFETKYHALQVIFVRMLATAIAGSLGMWYKKVPGFPFGPREVRGLLLLRGFAGTAGLIGLYYSLSYLAISDATVITFLVPTMTASISWVALHEPFTVKEAAAGFIAFTGVLFVARPAFLFPEGANASALSTGVESIVPGVVVQGGILPPPEVTPAERAIAIMCSIFGSFAAATAYSTIRAIGKRAHSLVSVNYFATLATVSSFLIIMIHPDLQFEIPKSTIEWILLLSIGVSGFLLQVLLTEGLQREKAGRATNLIYVQMVFALIIERVVWGTTPPVTSFVGSALIIGAAIWVTLQKKAPVEQTRLLDEERRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXS0</accession>
    <name>C7YXS0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_82627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049106.1">
        <property type="nucleotide sequence ID" value="XM_003049060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXS0"/>
    <dbReference type="GeneID" id="9666403"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82627"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82627"/>
    <dbReference type="HOGENOM" id="CLU_2223919_0_0_1"/>
    <dbReference type="InParanoid" id="C7YXS0"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU43393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="106" mass="11556" checksum="2410139BBDC1BC64" modified="2009-10-13" version="1">MEETSCPPPDIKSDYHADLTVSNRITIMPKKSANVDSNDGLPYSRKNTLHEAAAMQRVGMGPQCDDPVGRQVQPPNINVTHDVDDACVHPSDTQAPSETDVEDVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>C7YY80</accession>
    <name>C7YY80_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_95387</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU42958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048671.1">
        <property type="nucleotide sequence ID" value="XM_003048625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YY80"/>
    <dbReference type="FunCoup" id="C7YY80">
        <property type="interactions" value="1029"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YY80"/>
    <dbReference type="GeneID" id="9667796"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95387"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95387"/>
    <dbReference type="eggNOG" id="KOG0343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_26_1_1"/>
    <dbReference type="InParanoid" id="C7YY80"/>
    <dbReference type="OMA" id="YDKMFER"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17941">
        <property type="entry name" value="DEADc_DDX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="83"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="283"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="498"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="650"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="658"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="689"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="701"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="750"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="784"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU42958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="804" mass="90669" checksum="EE275E6D1170E583" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYJ8</accession>
    <name>C7YYJ8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxisomal ATPase PEX6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peroxin-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_47187</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with PEX1; forming the PEX1-PEX6 AAA ATPase complex, which is composed of a heterohexamer formed by a trimer of PEX1-PEX6 dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Peroxisome membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048729.1">
        <property type="nucleotide sequence ID" value="XM_003048683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYJ8"/>
    <dbReference type="FunCoup" id="C7YYJ8">
        <property type="interactions" value="283"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YYJ8"/>
    <dbReference type="GeneID" id="9665838"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_47187"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_47187"/>
    <dbReference type="eggNOG" id="KOG0736">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_0_2_1"/>
    <dbReference type="InParanoid" id="C7YYJ8"/>
    <dbReference type="OMA" id="KIMLCEP"/>
    <dbReference type="OrthoDB" id="5553750at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19527">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000108">
        <property type="entry name" value="Peroxisomal biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000109">
        <property type="entry name" value="Peroxisomal biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000039">
        <property type="entry name" value="peroxisome biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056995">
        <property type="entry name" value="PEX6_4th_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047533">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF9">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23315">
        <property type="entry name" value="PEX6_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="509"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="784"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1054"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1054"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1071"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1099"/>
            <end position="1111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU43016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1138" mass="122877" checksum="CAE631223B27A047" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYM1</accession>
    <name>C7YYM1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">PQ loop repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_46967</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the laat-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048928.1">
        <property type="nucleotide sequence ID" value="XM_003048882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYM1"/>
    <dbReference type="FunCoup" id="C7YYM1">
        <property type="interactions" value="361"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YYM1"/>
    <dbReference type="GeneID" id="9665925"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_46967"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_46967"/>
    <dbReference type="eggNOG" id="KOG2913">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019699_1_1_1"/>
    <dbReference type="InParanoid" id="C7YYM1"/>
    <dbReference type="OMA" id="DMCIFIQ"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098588">
        <property type="term" value="C:bounding membrane of organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015101">
        <property type="term" value="F:organic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034488">
        <property type="term" value="P:basic amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034490">
        <property type="term" value="P:basic amino acid transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000011">
        <property type="entry name" value="PQ loop repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF35">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER YPQ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="107"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="319"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU43215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="40438" checksum="3FB6F9F35A454B4C" modified="2009-10-13" version="1">MTPPTQILNLDVEAISGICGSISIACWVVVFSPQIIQNFQRSSADALSIQFIIVWLLGDVFNILGAVLQGVLPTMIILAIYYTIADLVLLGQCFYYRGFTWRDPPAHTPKPANPAPGEPNERTGLLSNGYHHHERRGSDWSGLSPAVPHIAEDATPQEPTVLQTLVWNSIIVMMVIAAGILGWFLGQKASGDKDNTGGEKQDSLEFNLLGQIFGYLCTVAYIASRLPQLILNWRRKTTDGLSMLFFLFACLGNITYVLSIFAYEPKCKHEHCKPGEASHIYGRYILVNLSWLAGSLVTLFLDLGVFAQYFMYSNPESNSIDGRQRRNNPIEDEEEYDDDQSIDEDRWDQRPLLQRGDSVYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYP2</accession>
    <name>C7YYP2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_71061</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048939.1">
        <property type="nucleotide sequence ID" value="XM_003048893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYP2"/>
    <dbReference type="GeneID" id="9665936"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_71061"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_71061"/>
    <dbReference type="eggNOG" id="KOG0475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003181_2_0_1"/>
    <dbReference type="InParanoid" id="C7YYP2"/>
    <dbReference type="OMA" id="TDWVHDT"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000013">
        <property type="entry name" value="Voltage-gated chloride channel (ClcA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF3">
        <property type="entry name" value="CLC CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0868">Chloride</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="495"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="553"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU43226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="862" mass="95649" checksum="55FF200435D664E8" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZ04</accession>
    <name>C7YZ04_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytidyltransferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_7866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048806.1">
        <property type="nucleotide sequence ID" value="XM_003048760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZ04"/>
    <dbReference type="STRING" id="660122.C7YZ04"/>
    <dbReference type="GeneID" id="9665653"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_7866"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_7866"/>
    <dbReference type="eggNOG" id="KOG3199">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033366_0_2_1"/>
    <dbReference type="InParanoid" id="C7YZ04"/>
    <dbReference type="OMA" id="PMQTHID"/>
    <dbReference type="OrthoDB" id="422187at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051182">
        <property type="entry name" value="Euk_NMN_adenylyltrnsfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039:SF0">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU43093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="149" mass="16952" checksum="1C4BB1797D407128" modified="2009-10-13" version="1" fragment="single">KQGLAPGHHRVEMCRLAAEDEYDWLTVDPWETESPTTIPTAQVLDHVDYEINDVIGGIECDEGTKRSAKIVLLAGLDLVQTMSTPGVWEKRDLDHILDRYGLFALERRGTETEPALASLEQWRQNIHIIHKHVTEDISSTKTRLLLKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZ08</accession>
    <name>C7YZ08_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_71173</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Cytoplasmic vesicle</location>
            <location evidence="10 11">COPI-coated vesicle membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Golgi apparatus membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003048950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZ08"/>
    <dbReference type="FunCoup" id="C7YZ08">
        <property type="interactions" value="1156"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YZ08"/>
    <dbReference type="GeneID" id="9666068"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_71173"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_71173"/>
    <dbReference type="eggNOG" id="KOG2635">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019988_3_0_1"/>
    <dbReference type="InParanoid" id="C7YZ08"/>
    <dbReference type="OMA" id="VQFRTHP"/>
    <dbReference type="OrthoDB" id="10266042at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051645">
        <property type="term" value="P:Golgi localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09254">
        <property type="entry name" value="AP_delta-COPI_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14830">
        <property type="entry name" value="Delta_COP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="13">
        <location>
            <begin position="284"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="155"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU43283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="522" mass="57629" checksum="A0C77B1BC523E78A" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZ10</accession>
    <name>C7YZ10_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF803 domain membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_83870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="GeneID" id="9665657"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83870"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83870"/>
    <dbReference type="eggNOG" id="KOG2922">
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    </dbReference>
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    <dbReference type="InParanoid" id="C7YZ10"/>
    <dbReference type="OMA" id="PMVYISI"/>
    <dbReference type="OrthoDB" id="6428174at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF85">
        <property type="entry name" value="DUF803 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G15880)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="360"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="384"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU43097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="43167" checksum="FE0FBD6D3E50A3CF" modified="2009-10-13" version="1">MLEDKYIGLALAMASALAIGTSFVITKKGLNQAEERHGFEGDGYVYLRNPLWWAGIATLGLGEVCNFAAYAFAPAILVTPLGALSVLIGAVLGSYFLNEELGTLGKLGSAICLIGAVVIVLHAPPDEDIQTIDQILHYAIQPGFLLYAIAVVAFAVFMIYKIAPVYGRRNALIYLSICSTVGSISVMSVKAFGIALKLTFAGHNQFTHPSTYVFMILTAVCILTQMNYFNKALACFPTNIVNPLYYVTFTTATLCASFILFSGFNTTDPTNTLSLICGFLTTFTGVYLLNLSRGDPHGHKLVAGRGGSDATGTDMVSGLQTRLSMSARRSADPSRHSMSSQHGDREGLIRAYDEEEAAGFGLTDLAEDSDEEMRHANGNGNGKARYDDSIELDNRNKSGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZW3</accession>
    <name>C7YZW3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_47592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048392.1">
        <property type="nucleotide sequence ID" value="XM_003048346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZW3"/>
    <dbReference type="STRING" id="660122.C7YZW3"/>
    <dbReference type="GeneID" id="9667658"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_47592"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_47592"/>
    <dbReference type="eggNOG" id="ENOG502T0M3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064975_0_0_1"/>
    <dbReference type="InParanoid" id="C7YZW3"/>
    <dbReference type="OMA" id="DIIAWLV"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="69"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="242" mass="26873" checksum="4D0ACA732F8238BD" modified="2009-10-13" version="1">MSNIIAWLVPTARNSTADKATHLPSNISRIVLTTSSQTLTSRLPNLLASRPPRAIQLTFDAAPKRPGSFVLGTDPASCDVVLPPMEGIDARHCELSFDAEGRLVLNDFSERGTQVWYDWESNGDQTDYTWILSSGSQHGFPSTVQRITVDIQGVRFQIVVNDHSDDWDAYHEKVDEFLQQPAWTEGLSAGWDRGSISPVAPLFSNVPLFQHIFVKALGEEPVGEVYLWNLARPWEPMVKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z001</accession>
    <name>C7Z001_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dockerin type 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_95849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048596.1">
        <property type="nucleotide sequence ID" value="XM_003048550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z001"/>
    <dbReference type="GeneID" id="9667492"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95849"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95849"/>
    <dbReference type="eggNOG" id="ENOG502SHSP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042057_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z001"/>
    <dbReference type="OMA" id="ATGAWWE"/>
    <dbReference type="OrthoDB" id="5319191at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045690">
        <property type="entry name" value="DUF6055"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19527">
        <property type="entry name" value="DUF6055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU42883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="46448" checksum="A8F1A29278D8E25D" modified="2009-10-13" version="1">MSAPLLPFPWSPSIQAPWPRSLSEPATFEANPNVGNGGSNFKDSARFRVYGASSAEADEALEMLEGAYDCFIGKLGWRSSGLTFYDNDDTYYKTNFYTVSSLDGGAAGLQHSDMESGFGYVEVLQEYLTNPQITVHEYGHVVHFHQRTWVNQANTGAWWETVANWFSDTYKTSDICAEAREKHGQSTSPTEIDLQKVIGDSFQVIVDGSTDSGNYYQAWPFLTYLTSNPDNFAGLGQDVIRQLMVQYPEDSNETPLHTLSRVSENATVTEIVGRYWAHMAYLDIGHPSAKEAFLSQRDTLNFDNLESQGSDSYKVKTDRQPRYMGSNIIPLTSSGDGKVEVKVECDAAFTATLAIHETSSGKIRYVSLVDGAASASVASGEEASLVVANTPAELINYDAFNLSEDVQKGLDYTVTITGATTGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z148</accession>
    <name>C7Z148_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phenylacetaldoxime dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_39778</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048014.1">
        <property type="nucleotide sequence ID" value="XM_003047968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z148"/>
    <dbReference type="GeneID" id="9671825"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_39778"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_39778"/>
    <dbReference type="eggNOG" id="ENOG502SHKM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065607_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z148"/>
    <dbReference type="OMA" id="FRTWHEV"/>
    <dbReference type="OrthoDB" id="3359285at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025702">
        <property type="entry name" value="OXD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13816">
        <property type="entry name" value="Dehydratase_hem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU42301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="40578" checksum="0ECC6AE1A4E3D6E9" modified="2009-10-13" version="1">MSCPARIYPLRKPKNHRLPIPRWRLALPRDTTHVYTAYIGIQKHSNDQATSDAQKEATSAIQAWLKGHHGPSAFESFTVIDGSDVEETSIWVSYWLEESKYKLSIEKLSLPSIYSSLSTPGRASIGIWREAFTTEVPRLETNYSGLDYLPGLARLPGTSFPEHEFSAYWGAARDRIPSSAYDLFPQSADTVPPTTVPRGIGQYLTGTNAENIAHIRSGQFWENCGQEEADAYDSKLEPTLRSGLEYLWENSPDTGALGLRYLRNHDIDSPDERLRKETCGAGFFTSLETLENWAKSHRSHLAIYRGAMAHYKAFGDRRKMRTWHEVSVLRGGDAKFEYLNCVPKTGVIRGISLTAEDIEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1H6</accession>
    <name>C7Z1H6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_101970</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU42170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047883.1">
        <property type="nucleotide sequence ID" value="XM_003047837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1H6"/>
    <dbReference type="GeneID" id="9671506"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101970"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101970"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1786948_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z1H6"/>
    <dbReference type="OMA" id="GCESMFS"/>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000343">
        <property type="entry name" value="C2H2 transcription factor (AmdX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000576">
        <property type="entry name" value="C2H2 transcription factor (AmdX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF13">
        <property type="entry name" value="RESPIRATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="87"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU42170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="164" mass="18553" checksum="BC78534564506294" modified="2009-10-13" version="1">MSNPPSSNAAVLSVPSTDDDSASMIIADTKVSANFPPPKTDKPRPHVCGTCQRSFARLEHLERHERSHTKEKPFECPECNRRFARRDMLLRHQQKLHQTSTPSSRPRNRRESAGGIPSGQQGDHVICQYPTYGQLYPVPQFNGVDVGSWKMDEENKWLPSIDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1X8</accession>
    <name>C7Z1X8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal protein bL31m N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_9344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU42076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047789.1">
        <property type="nucleotide sequence ID" value="XM_003047743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1X8"/>
    <dbReference type="STRING" id="660122.C7Z1X8"/>
    <dbReference type="GeneID" id="9671752"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_9344"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_9344"/>
    <dbReference type="eggNOG" id="ENOG502RZ6E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2164425_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z1X8"/>
    <dbReference type="OMA" id="QCRNANL"/>
    <dbReference type="OrthoDB" id="5587740at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034600">
        <property type="entry name" value="Ribosomal_bL31m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048874">
        <property type="entry name" value="Ribosomal_bL31m_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL31M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21492">
        <property type="entry name" value="bL31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein bL31m N-terminal" evidence="1">
        <location>
            <begin position="28"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="111" mass="12363" checksum="D43C75BF48F97498" modified="2009-10-13" version="1" fragment="single">RTTLSSTSTSSPTRFSLGQVRHATFIPRPRRPYTFTQLVTLSDGSAYTMRTTSPLPIYRATKDTRNTLLWQPSEKSLKNVELDEAGKLAAFRERFGRAYDSGTGEGDEADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z253</accession>
    <name>C7Z253_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="7">3.4.21.92</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_73923</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="7"/>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU41941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047654.1">
        <property type="nucleotide sequence ID" value="XM_003047608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z253"/>
    <dbReference type="STRING" id="660122.C7Z253"/>
    <dbReference type="MEROPS" id="S14.001"/>
    <dbReference type="GeneID" id="9671789"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_73923"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_73923"/>
    <dbReference type="eggNOG" id="KOG0840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058707_7_1_1"/>
    <dbReference type="InParanoid" id="C7Z253"/>
    <dbReference type="OMA" id="RDYWMKA"/>
    <dbReference type="OrthoDB" id="2017408at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009368">
        <property type="term" value="C:endopeptidase Clp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381:SF11">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0720">Serine protease</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU41941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="157" mass="17141" checksum="1208B38C14C70DC5" modified="2009-10-13" version="1">MYINSPGGSVTSGMAIYDTMSYIKSPVSTVCVGGAASMAAILLAGGEAGKRFSLPHSSIMIHQPLGGTRGQASDILIYANQIQKIREQSNHIMQYHLNKAKGHDKYTIEEINDLMERDKYLSPDEALELGVIDEILTKRPESEQEKKDGQSEAPKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z3V0</accession>
    <name>C7Z3V0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_83376</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046916.1">
        <property type="nucleotide sequence ID" value="XM_003046870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z3V0"/>
    <dbReference type="STRING" id="660122.C7Z3V0"/>
    <dbReference type="GeneID" id="9675493"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83376"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83376"/>
    <dbReference type="eggNOG" id="KOG0259">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_4_1"/>
    <dbReference type="InParanoid" id="C7Z3V0"/>
    <dbReference type="OMA" id="MIKASEF"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510:SF1">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="45"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU41203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="390" mass="42724" checksum="67871820FAB812A3" modified="2009-10-13" version="1">MPEIPELNIDKWIEEYGVCRPSPEDSYASALSLNELQQLAPNTTLLDPGLALTYGTALGSVRLRERIAKLHSSPNVRLTAANVVITPGSSMANHLVLATLCGPSDHIICQYPTYGPLYLLPKHNGVDVSFWGLKEADGWSLDMGELAGMIQPNTKVIIICNPNNPTGTVLPRDTLDQVIALAQKHNIVVFSDEVFSPLFHTNDRAPPLVSIGSPGTVSTGSLSKAYALPGIRIGWVISQDKDIIHRVSVLRDYTTISVSLLDDSVASFALSEEVLPRLMERNLKLCAESITLIDEFVKRNSQRCRWTKPKGSGVAFVQILNKDKSPSDDLDFSKKLVEEAGIVVLPGSYSFAEEGANDLKGYLRIEIGSPGRLREALVALEEFVHKYESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z3V3</accession>
    <name>C7Z3V3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_95267</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046919.1">
        <property type="nucleotide sequence ID" value="XM_003046873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z3V3"/>
    <dbReference type="FunCoup" id="C7Z3V3">
        <property type="interactions" value="79"/>
    </dbReference>
    <dbReference type="GeneID" id="9678658"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95267"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95267"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009084_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z3V3"/>
    <dbReference type="OMA" id="FAGVWRK"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015137">
        <property type="term" value="F:citrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000172">
        <property type="entry name" value="MFS multidrug resistance transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF151">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="490"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="513"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="549"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="579"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="664"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="698"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="753"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="780"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="818"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="845"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="425"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU41206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="885" mass="97382" checksum="F4A07128DDCEC666" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z429</accession>
    <name>C7Z429_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_83458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046960.1">
        <property type="nucleotide sequence ID" value="XM_003046914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z429"/>
    <dbReference type="GeneID" id="9675296"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83458"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83458"/>
    <dbReference type="eggNOG" id="ENOG502T2WV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_582761_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z429"/>
    <dbReference type="OrthoDB" id="5106956at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU41247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="469" mass="51859" checksum="92F490B2683B6C46" modified="2009-10-13" version="1">MTTNADFTFTPHPSPEEIQDEWNLSLHGIEDEGENQAVIAHLRSIWRDNWWKYPDKIKQSFLNAARKTATTKTNIHSPCSHTLYRGAFIRNTHDFDWGVWLVLRGIYYDSLKDAATARAEMTRQTFARSPATKAIMQRYQDIDVLEDNVPLTFPPRPSSWEKKLEDGPGGSCTPPKTKDRTPAVKCPATNKTGGTGDGTRDSGVGSSTEMAKGEGVGSPSPDKTKTKVKKEAKKHTSAPSQGTSSHPRTNLDTTPSDSKTKAISIQGPVNEGGQREKSTNASNNSKVCPEEPSTAPKRLPKRSLSDDEEESQLRIKRRSTSSDQSRHSPEVKTEAIPNGCLQIATFNETLEHIYERIKKPINEKATEYVSQQVTQHLEDLQPRLKDLAIQLLSEMIPVIPRSSESSTIAQQIADSMAEQVLSIITGPVIQKLTTRLISELQPVVDKQIANGIAQHLLENLFGSTGSSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4Q1</accession>
    <name>C7Z4Q1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">COP9 signalosome complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_5151</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M67A family. CSN6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046101.1">
        <property type="nucleotide sequence ID" value="XM_003046055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4Q1"/>
    <dbReference type="STRING" id="660122.C7Z4Q1"/>
    <dbReference type="GeneID" id="9678207"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_5151"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_5151"/>
    <dbReference type="eggNOG" id="KOG3050">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027018_2_0_1"/>
    <dbReference type="InParanoid" id="C7Z4Q1"/>
    <dbReference type="OMA" id="LVGWWST"/>
    <dbReference type="OrthoDB" id="1378at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08063">
        <property type="entry name" value="MPN_CSN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033859">
        <property type="entry name" value="MPN_CSN6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF8">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="MPN" evidence="4">
        <location>
            <begin position="15"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="215"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU40388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="386" mass="42530" checksum="BC16CDBBC2EB294B" modified="2009-10-13" version="1" fragment="single">SNPLLSNQKSSELQAVLHPLVLLTISDYITRHTLRQQTGPIVGALLGQQNGREITIEHAFEAHTMEAPNTQGGYLLHAEKFGARLEQMITVHKDRQLDFVGWYTLLPSSGPTPTILPIHNQILEGWNESAVLLGFHPEQVLDHSVGGKLPLTIYESNYEVDDPRADNNDGEDRKMDDGEPTLKLKFRELPYSVETDETEMISMNYVAASGGNAAVAAPKEEKPSLSVESNGKGKRRLVESQDEERKPEDDAAALTPEEDEMIAALTAKANAIKMLQSRINLLTTYLERLPPSYVNGDATDSGSMDADYTTPSTTVLRQIQALVSRLDLVIPSDEASFEREMLHEANDVNLVGLLNGIMQSVNQARDVGKKFNVVEMSKATSRRGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z5F7</accession>
    <name>C7Z5F7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein transport protein SEC13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Protein transport protein sec13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NECHADRAFT_76851</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU41092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046805.1">
        <property type="nucleotide sequence ID" value="XM_003046759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z5F7"/>
    <dbReference type="FunCoup" id="C7Z5F7">
        <property type="interactions" value="1065"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z5F7"/>
    <dbReference type="GeneID" id="9678332"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76851"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76851"/>
    <dbReference type="eggNOG" id="KOG1332">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032441_0_1_1"/>
    <dbReference type="InParanoid" id="C7Z5F7"/>
    <dbReference type="OMA" id="IWKEEGD"/>
    <dbReference type="OrthoDB" id="364224at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051664">
        <property type="term" value="P:nuclear pore localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902953">
        <property type="term" value="P:positive regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070863">
        <property type="term" value="P:positive regulation of protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000017">
        <property type="entry name" value="SEC13 homolog (S. cerevisiae)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="6 13" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="55"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="14">
        <location>
            <begin position="96"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="213"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU41092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="308" mass="33828" checksum="3FEE8DE303E18856" modified="2009-10-13" version="1">MAAQVISNSGHEDMILLQHDAVLDYYGRKLATCSSDKTIKIFEIEGETQRLLETLKGHEGAVWCVAWAHPKYGNILASAGYDGKVFIWKEQGGQNSSWQRIYDFPLHKASVNIVSWSPHEAGCLLACASSDGNVSVLEFKDNSIDHTTFAAHGLGVNSVSWAPATTPGSIVSSAPGPAATGNRRFVTGGCDNVLKIWAFDPASQSYKQETEPLVGHNDWVRDVAWSPTVLQKSYIASASQDKTVRIWTSDPSNPTQWDSKVLNFEAAVWRVSWSLSGNVLAVSGQDNKVSLWKENLRGEWECVKSIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z5G2</accession>
    <name>C7Z5G2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinetochore protein NDC80</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">NECHADRAFT_33176</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Chromosome</location>
            <location evidence="11">Centromere</location>
            <location evidence="11">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the NDC80/HEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU41095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046808.1">
        <property type="nucleotide sequence ID" value="XM_003046762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z5G2"/>
    <dbReference type="FunCoup" id="C7Z5G2">
        <property type="interactions" value="262"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z5G2"/>
    <dbReference type="GeneID" id="9678613"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_33176"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_33176"/>
    <dbReference type="eggNOG" id="KOG0995">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012583_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z5G2"/>
    <dbReference type="OMA" id="PSHKFQK"/>
    <dbReference type="OrthoDB" id="7459479at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.30:FF:000001">
        <property type="entry name" value="Probable kinetochore protein ndc80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.30">
        <property type="entry name" value="Ncd80 complex, Ncd80 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005550">
        <property type="entry name" value="Kinetochore_Ndc80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055260">
        <property type="entry name" value="Ndc80_CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057091">
        <property type="entry name" value="NDC80_loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038273">
        <property type="entry name" value="Ndc80_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03801">
        <property type="entry name" value="Ndc80_HEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24487">
        <property type="entry name" value="NDC80_loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 11" id="KW-0137">Centromere</keyword>
    <keyword evidence="3 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Ndc80 CH" evidence="14">
        <location>
            <begin position="112"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Kinetochore protein NDC80 loop region" evidence="15">
        <location>
            <begin position="444"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="322"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="388"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="591"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF24487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEU41095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="727" mass="82612" checksum="FA06C3EC65166C62" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z5M2</accession>
    <name>C7Z5M2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_91391</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>adenosine + H2O + H(+) = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046261.1">
        <property type="nucleotide sequence ID" value="XM_003046215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z5M2"/>
    <dbReference type="STRING" id="660122.C7Z5M2"/>
    <dbReference type="GeneID" id="9678367"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_91391"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_91391"/>
    <dbReference type="eggNOG" id="KOG1097">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022829_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z5M2"/>
    <dbReference type="OMA" id="YQPRQTM"/>
    <dbReference type="OrthoDB" id="7202371at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000017">
        <property type="entry name" value="Adenosine deaminase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF37">
        <property type="entry name" value="ADENOSINE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="10">
        <location>
            <begin position="265"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU40548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="594" mass="67850" checksum="9CD1102B26E7F561" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z606</accession>
    <name>C7Z606_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_33373</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046326.1">
        <property type="nucleotide sequence ID" value="XM_003046280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z606"/>
    <dbReference type="GeneID" id="9668517"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_33373"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_33373"/>
    <dbReference type="eggNOG" id="ENOG502SRVW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_0_3_1"/>
    <dbReference type="InParanoid" id="C7Z606"/>
    <dbReference type="OMA" id="LIWIIIR"/>
    <dbReference type="OrthoDB" id="5421689at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="30"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="345"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU40613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="389" mass="43402" checksum="52C0CB707466FFE6" modified="2009-10-13" version="1">MGSTKIPSKQPDLWAAEFVTFTAATIFLILRLVSRRLTRIRLWWDDYFALMCYTMALGWLVLVPIWIQNGFGLHIWDIKHMTKEKALFQTKLLLYIAELMYASALFFAKASILSFYWRMFRVTNIKLPIQILFTCAVIWIIIRTFMGIFHCVPVQTFWDSSVKGTCAIEDSKFFFGTILVHVILDICILILPILQIRKLQLPGLQKLGVMVMFLFGIIICVAAMVIIVASTEYDNTSDDMTWNLSTIVIWASVEVNLVTVSACLPTVRPACIYLFTCTHPISSIGSGSNSYGQAYGRSQTKKSIRLSTLPKGNEGESSSTHQLAETEAGRGSVSDFESHALDRYRGNTSTITGPGHDGSSDDFPTGSAFGGIMVKNETTVRVSTAGQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z671</accession>
    <name>C7Z671_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_33967</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046360.1">
        <property type="nucleotide sequence ID" value="XM_003046314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z671"/>
    <dbReference type="STRING" id="660122.C7Z671"/>
    <dbReference type="GeneID" id="9668548"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_33967"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_33967"/>
    <dbReference type="eggNOG" id="ENOG502SIJX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005594_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z671"/>
    <dbReference type="OMA" id="IYCWRNG"/>
    <dbReference type="OrthoDB" id="3915838at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01833">
        <property type="entry name" value="XynB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF31">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988530" description="SGNH hydrolase-type esterase domain-containing protein" evidence="3">
        <location>
            <begin position="29"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="4">
        <location>
            <begin position="69"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU40647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="908" mass="100805" checksum="71946C59D9C9CF87" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6J5</accession>
    <name>C7Z6J5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Threonine/serine exporter-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_66128</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045855.1">
        <property type="nucleotide sequence ID" value="XM_003045809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6J5"/>
    <dbReference type="FunCoup" id="C7Z6J5">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="GeneID" id="9668053"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_66128"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_66128"/>
    <dbReference type="eggNOG" id="ENOG502QPMM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007078_2_1_1"/>
    <dbReference type="InParanoid" id="C7Z6J5"/>
    <dbReference type="OMA" id="KKRVGWH"/>
    <dbReference type="OrthoDB" id="413008at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="559"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="610"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="649"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="691"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="818"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="876"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="4">
        <location>
            <begin position="426"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="310"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="792"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="801"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU40142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="911" mass="99591" checksum="5EB6D8D9E6292FC2" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z702</accession>
    <name>C7Z702_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_58032</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046498.1">
        <property type="nucleotide sequence ID" value="XM_003046452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z702"/>
    <dbReference type="GeneID" id="9668841"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_58032"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_58032"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_2_1"/>
    <dbReference type="InParanoid" id="C7Z702"/>
    <dbReference type="OMA" id="HIELYQM"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19146">
        <property type="entry name" value="AKR_AKR9A1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF7">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="29"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU40785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="377" mass="41976" checksum="BE5DFDA716A5AF06" modified="2009-10-13" version="1">MALPMAPPPKSPLGHYRLLSPSAAVRVSPLCLGTMNFGNAWKDYMGECDQSTTEAILDFFYEQGGNFLDTANNYHFQESEKWVGEWMKKRGVRDEMVVATKYTTNFRAGPKGPNVMANFTGNGTKSLVTSVNSSLKNLQTDYIDLLYVHWWDYSTSIPELMQSLNQLVLSGKVLYLGISDTPAWVVSKANEYARNNGLRQFSVYQGRWSAASRDFEREIIPMCRAEGMGIAPWGALGGGKFKTEEQRKAQEGRKVEASQGEIKTSQVLESIADRKNSLITSVALAYVMHKTPYVFPIVGGRKVEHLRGNIEALTLELTEEDINEIDSAVEFDPGFPHNFLHRPGQVIGGQDVWLLKMGGTFDNVPPPKPISPAKRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z721</accession>
    <name>C7Z721_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="7">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_34322</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Vacuole membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="7"/>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046507.1">
        <property type="nucleotide sequence ID" value="XM_003046461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z721"/>
    <dbReference type="FunCoup" id="C7Z721">
        <property type="interactions" value="250"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z721"/>
    <dbReference type="GeneID" id="9668217"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_34322"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_34322"/>
    <dbReference type="eggNOG" id="KOG2381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009049_2_0_1"/>
    <dbReference type="InParanoid" id="C7Z721"/>
    <dbReference type="OMA" id="NWMVKVD"/>
    <dbReference type="OrthoDB" id="3349449at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039756">
        <property type="entry name" value="Lsb6/PI4K2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="162"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="313"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="417"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="591"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="646"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU40794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="782" mass="88539" checksum="DD874F1AE579E9B0" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7H0</accession>
    <name>C7Z7H0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">18S rRNA factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_17606</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF2/ABP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046583.1">
        <property type="nucleotide sequence ID" value="XM_003046537.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7H0"/>
    <dbReference type="FunCoup" id="C7Z7H0">
        <property type="interactions" value="926"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z7H0"/>
    <dbReference type="GeneID" id="9668368"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_17606"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_17606"/>
    <dbReference type="eggNOG" id="KOG3152">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054086_0_1_1"/>
    <dbReference type="InParanoid" id="C7Z7H0"/>
    <dbReference type="OMA" id="TRKHNDF"/>
    <dbReference type="OrthoDB" id="287393at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034462">
        <property type="term" value="P:small-subunit processome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12263">
        <property type="entry name" value="RRM_ABT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001147">
        <property type="entry name" value="Pre-rRNA-processing protein esf-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039119">
        <property type="entry name" value="ABT1/Esf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034353">
        <property type="entry name" value="ABT1/ESF2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311:SF7">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="114"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU40870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="315" mass="35568" checksum="3F8B0312C01FEC54" modified="2009-10-13" version="1" fragment="single">KNDFLDTADSDEENDVGYNSEDEVTKGGHTAKRRKLDSDDEDDLGSDNDRDASDNEDDAAEGGADLKEDEEAKDEPRKSKRKSKASLSTELPDITKPLTKKNLVASEAAIKKSGVVYLSRIPPFMKPAKLRSLLEPYGTINRIFLAPEDPASHARRVRAGGNKKRSYTEGWVEFVNKKEAKTVCELLNARTIGGKKGSYYRDDLWNLLYLKGFKWHNLTEQIATENAERTSRMRAEISKTTRENKEFVRNVEKAKMLDGMEAKAKAKKRKAGAEEQGEDEVRQVKRSFKQVPLAKKRTEVEEQPAEVARVLSKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7V0</accession>
    <name>C7Z7V0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_79566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045602.1">
        <property type="nucleotide sequence ID" value="XM_003045556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7V0"/>
    <dbReference type="GeneID" id="9672630"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79566"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79566"/>
    <dbReference type="eggNOG" id="ENOG502TGUQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1496623_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z7V0"/>
    <dbReference type="OrthoDB" id="4985941at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="180" mass="20194" checksum="28E80D2874F94627" modified="2009-10-13" version="1">MCQAVRYVYPGCGHPIRPDSDTWYLERCRIAHDTDSNCWLPRSPPPEFMQERVYHGEDLAEECATCLTLNAWDDDDAVRAWGSFFEGEESDVEDEDEEGDSDAGNTAQQDTTQRPTRADTSAGPSAEELREAEDLQWAINKMIEIDSDAGGETPPSPENRRLGSASMNLQSSQPSEMEYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z899</accession>
    <name>C7Z899_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate esterase family 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_106081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045673.1">
        <property type="nucleotide sequence ID" value="XM_003045627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z899"/>
    <dbReference type="GeneID" id="9672447"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_106081"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_106081"/>
    <dbReference type="eggNOG" id="ENOG502SIJX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053370_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z899"/>
    <dbReference type="OMA" id="ILWINCG"/>
    <dbReference type="OrthoDB" id="2119228at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01833">
        <property type="entry name" value="XynB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF5">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU39960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="460" mass="49621" checksum="8798361530333437" modified="2009-10-13" version="1">MEDESSGSCSIDLPDGDVVLKYKQTEAGEPVKKGTKLRILPVGDSITVGYLSDRNGGDGNGYRGRLKKDLSGDEVVFAGTESSGTMSDGYYAAWSGKTIQYISDHVRPSLEQRPNIILLAAGTNDMNPNRGISKEGNDPKGAADRLGKLVDKMIKECPDATILVAMIINTCDEKQSPATKEFQKLIPDVVKSRREDGHQVLAVDFTTFKTSDLQDCIHPTNSGYKLMGDYWYSFIHQIPTSWIKKPVGSDPNSGGSGNNGGESWTACNKNPIWKGAGKIAQGNVGHNGDWKYHKNWVAEGEVAEGLGWDTRYVPGNNNSIIGSGVGPAETIFLADMNGDGMDDYLVVDPDNGSVRVWWNYGPDDNWVNGWKFVPGGQIASSVPHANLETIRFPDVNGDGRADYVYIGEGGSLKHHMNTGSAGGQDVLFHAMGGIATGAVRNLSNLVFADVSFPCLNGHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z944</accession>
    <name>C7Z944_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAM50A/XAP5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_100827</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU38955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044668.1">
        <property type="nucleotide sequence ID" value="XM_003044622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z944"/>
    <dbReference type="STRING" id="660122.C7Z944"/>
    <dbReference type="GeneID" id="9673081"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100827"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100827"/>
    <dbReference type="eggNOG" id="KOG2894">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037985_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z944"/>
    <dbReference type="OMA" id="DFIWVFL"/>
    <dbReference type="OrthoDB" id="1562195at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048337">
        <property type="entry name" value="FAM50A/XAP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007005">
        <property type="entry name" value="XAP5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722:SF0">
        <property type="entry name" value="PROTEIN FAM50A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722">
        <property type="entry name" value="XAP-5 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04921">
        <property type="entry name" value="XAP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM50A/XAP5 C-terminal" evidence="2">
        <location>
            <begin position="175"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU38955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="365" mass="40244" checksum="16DB20A2D1CA162D" modified="2009-10-13" version="1">MSDQGSSRFTPQNKTTHERLSTHTVGLVALSDFRKRRAEVLEQQEREAHEAAFSGTSTPDRSLTGTPDNGGSDTGSGPRPVKKQKKKKLGKKLLSFDDEEGDEEAAPSKPTPKAKKDSAIDTEGSDSDVKAKFKANASVGIVPKAMTKSALRKEAAEREALRREFLAIQEAVKATEIAIPFVFYDGSNIPGGTVRVKKGDYVWVFLDKSRKVGAELGVGEKANARREWARVGVDDLMLVRGTVIIPHHYDFYFFAMNKTLGPGGQPVFDYSAEAPQKPEFTDDAKPSDPLVTPASKVATAKALPDVDTLEGATDDPSLTKVVDRRWYEKNKHIFPASMWQEFDPEKDYGREVRKDAGGNTFFFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9B0</accession>
    <name>C7Z9B0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_94436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044781.1">
        <property type="nucleotide sequence ID" value="XM_003044735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9B0"/>
    <dbReference type="STRING" id="660122.C7Z9B0"/>
    <dbReference type="GeneID" id="9673766"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94436"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94436"/>
    <dbReference type="eggNOG" id="ENOG502S3UW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066707_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z9B0"/>
    <dbReference type="OMA" id="HADKLQM"/>
    <dbReference type="OrthoDB" id="63935at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004074">
        <property type="term" value="F:biliverdin reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="9"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU39068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="241" mass="26126" checksum="38C53E8E8A332E17" modified="2009-10-13" version="1">MSKTIAFFGATGGCGLSALKLAVANNHTCVALCRNPDKLSTLFPSKPANLAAIKGNAHDPEAVASCLVNPADPSRLVDIVCFTIGSVFSFAKLTTEDPNVCEKAMDALFKALDALRQQGKTGRPLLAVISTTGISKFQRDVPIAFLPLYKALHVPHEDKRIMEEKLQAGSERWVAVRPSLLVDGAVPDRKIRVGVEDPVKGVEVKEFGYTISREDVGRWMYENLIVGETGRYEGKAVGITW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9B3</accession>
    <name>C7Z9B3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_100902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045185.1">
        <property type="nucleotide sequence ID" value="XM_003045139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9B3"/>
    <dbReference type="STRING" id="660122.C7Z9B3"/>
    <dbReference type="GeneID" id="9673768"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100902"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100902"/>
    <dbReference type="eggNOG" id="ENOG502S8WW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064787_2_0_1"/>
    <dbReference type="InParanoid" id="C7Z9B3"/>
    <dbReference type="OMA" id="FFCETRR"/>
    <dbReference type="OrthoDB" id="2687876at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052396">
        <property type="entry name" value="Meiotic_Drive_Suppr_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06293">
        <property type="entry name" value="Kdo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU39472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="31427" checksum="DC8F48CEF2B3B13D" modified="2009-10-13" version="1">METNSNVKLLAVLADPDDAEQSEYRFLVDDAHVRYVTLDGGLISGVDRTYAPVLLSQLPPFPPGDWNEGRVGKDERTGEPCFCETRRSSLPGIGDVWHKTMIDHLELHQLDHIRQTLYRVTHPSFDRPVLAKFAQFPWEIPYFAAETTSYEWIHGRGIGPAFLGHIHENGRVIGFLIEEVPDARTAEPDDLAACQRSLQKLHELGILHGDINKHNFLIRGGDGEAVLIDFETAHKCTDQELIDAEYKHLQDSLADTSGRGGAGLMDWTFDNRIDETFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9G4</accession>
    <name>C7Z9G4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_43320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044804.1">
        <property type="nucleotide sequence ID" value="XM_003044758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9G4"/>
    <dbReference type="STRING" id="660122.C7Z9G4"/>
    <dbReference type="GeneID" id="9673789"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_43320"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_43320"/>
    <dbReference type="eggNOG" id="ENOG502S0CM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_430823_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z9G4"/>
    <dbReference type="OMA" id="FLIHMPR"/>
    <dbReference type="OrthoDB" id="4925544at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="583" mass="65166" checksum="5124BE47C1A6534D" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9J6</accession>
    <name>C7Z9J6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prephenate dehydrogenase [NADP(+)]</fullName>
            <shortName evidence="2">PRDH</shortName>
            <ecNumber evidence="2">1.3.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_62071</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>prephenate + NADP(+) = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21640"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NADP(+) route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prephenate/arogenate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.13" evidence="2"/>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045228.1">
        <property type="nucleotide sequence ID" value="XM_003045182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9J6"/>
    <dbReference type="FunCoup" id="C7Z9J6">
        <property type="interactions" value="243"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z9J6"/>
    <dbReference type="GeneID" id="9673808"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_62071"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_62071"/>
    <dbReference type="eggNOG" id="KOG2380">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031403_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z9J6"/>
    <dbReference type="OMA" id="WRVNACD"/>
    <dbReference type="OrthoDB" id="5399569at2759"/>
    <dbReference type="UniPathway" id="UPA00122">
        <property type="reaction ID" value="UER00962"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3660.10:FF:000002">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3660.10:FF:000004">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3660.10">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046825">
        <property type="entry name" value="PDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050812">
        <property type="entry name" value="Preph/Arog_dehydrog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012385">
        <property type="entry name" value="Prephenate_DH_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363:SF0">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20463">
        <property type="entry name" value="PDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036510">
        <property type="entry name" value="PDH_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0827">Tyrosine biosynthesis</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR036510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU39515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="411" mass="46284" checksum="35F2D842BC80F925" modified="2009-10-13" version="1">MENFVVGLIGMGDMGKMYAERLSAAGWSIKNIEICRNGHLVSRASDYIIYSVEAAVIDRVIAQYGPSTKLGAIVGGQTSCKSPEIAAFEAHLPTDVSIISCHSLHGPNVDPYNQPLVLIQHRAPNEALAKVEAVLSCLRSKFVYLSAREHDRITADTQAVTHAAFLSMGKAWHANRQFPWELSRYVGGIENVKVNIMLRIYSQKWHVYAGLAILNPEAREQIAQYARSVTDLYKLMLEGNFEGLRDRVYQARDKVFGPSTTWGTRPLLEPSILSSFSLGTPTDEPRPNNHLSLLAMVDCWAALNIVPYDHMLCSTPLFRLRLGVTEYLFRNGDVLDAAIRTAIEDKTYRSDDLEFTFAARAWAECVSLGHFETWEKRFVSTQEFFEPRFEEAKVVGNQMMKKVLESLREEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZA78</accession>
    <name>C7ZA78_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_70532</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044939.1">
        <property type="nucleotide sequence ID" value="XM_003044893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZA78"/>
    <dbReference type="STRING" id="660122.C7ZA78"/>
    <dbReference type="GeneID" id="9672299"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_70532"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_70532"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_6_16_1"/>
    <dbReference type="InParanoid" id="C7ZA78"/>
    <dbReference type="OMA" id="PRYRASC"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031351">
        <property type="entry name" value="NWD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17108">
        <property type="entry name" value="HET-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="4">
        <location>
            <begin position="100"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="583"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="762"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU39226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="905" mass="101441" checksum="43BA57C38769F899" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAM9</accession>
    <name>C7ZAM9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transketolase-like pyrimidine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_94736</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045420.1">
        <property type="nucleotide sequence ID" value="XM_003045374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAM9"/>
    <dbReference type="STRING" id="660122.C7ZAM9"/>
    <dbReference type="GeneID" id="9672375"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94736"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94736"/>
    <dbReference type="eggNOG" id="KOG0523">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZAM9"/>
    <dbReference type="OMA" id="DICNQNG"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF6">
        <property type="entry name" value="TRANSKETOLASE-LIKE PYRIMIDINE-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="9">
        <location>
            <begin position="354"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU39707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="614" mass="66779" checksum="9035C8E8A0A1A49C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAQ5</accession>
    <name>C7ZAQ5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ornithine aminotransferase</fullName>
            <ecNumber evidence="5">2.6.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_88902</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 2-oxocarboxylate + L-ornithine = L-glutamate 5-semialdehyde + an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:13877"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="EC" id="2.6.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="5"/>
    <dbReference type="EMBL" id="GG698913">
        <property type="protein sequence ID" value="EEU38900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044613.1">
        <property type="nucleotide sequence ID" value="XM_003044567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAQ5"/>
    <dbReference type="STRING" id="660122.C7ZAQ5"/>
    <dbReference type="GeneID" id="9672914"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88902"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88902"/>
    <dbReference type="eggNOG" id="KOG1402">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_3_1"/>
    <dbReference type="InParanoid" id="C7ZAQ5"/>
    <dbReference type="OMA" id="ATMHAMR"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019544">
        <property type="term" value="P:L-arginine catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010121">
        <property type="term" value="P:L-arginine catabolic process to proline via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="ORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU38900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="430" mass="46368" checksum="BDAF04EA0D3EE497" modified="2009-10-13" version="1">MGSFSPLTKTAEVNNDYDTYVAGGFAPLPIALTSAQGSIAYGVDGKSYIDFLSMIAVTNMGHGHPRIVKAAVEALQTGATINLVVQNPHYGQLARRITQMFNYDRFVALTSGGEVVDAAMKMARKWGYLVKGIPMGKCCILSASRCYHGVGISNLSLFSFKSSLFQPFDPNNGHISPSGHEVRFGYLEDLKKAFEADAKNITAFIIEPIQGASGVIVPPEDYLPGVAKLCKQCNVLLILDEVQTGLGRCGYPLYQMKYGIRADLVVLGKALSGGLSPMSGVLGDNEVMELLDPVDLKGCAAALAALNVLVDEELSARADEMGDLMISTIKAMKPPHVIEYTGDALLRAIVITEKEPHVTARRLGALLVQRGLIANGMKGGRIRLYPPLNIDRELLIRGAEMVAQALIDLEGIPETLPGEIIPFKYGHYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZB77</accession>
    <name>C7ZB77_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prion-inhibition and propagation HeLo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_83000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044358.1">
        <property type="nucleotide sequence ID" value="XM_003044312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZB77"/>
    <dbReference type="GeneID" id="9672893"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83000"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83000"/>
    <dbReference type="eggNOG" id="ENOG502RMF4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093917_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZB77"/>
    <dbReference type="OMA" id="ASKPYDQ"/>
    <dbReference type="OrthoDB" id="5084929at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="22805" checksum="15388786318B161B" modified="2009-10-13" version="1">MKDERVSDHIRFPRYSYRVSRRTDGMSGYNDVMGRAVLICIINDLADVVDAVEDLRLPSRPEDRARLRIERRKMCDSVIKGANDLTAIFDSVKTESKYTDLAPKNLPQYRNQICGQLLNPLRKSDPRRATTYGRPFSFTPYREKLRIILSGIERELRRWLKVPREETRKSTKHGGQQQKSRSHRGSSPPNPGLCTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBB4</accession>
    <name>C7ZBB4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_22508</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044528.1">
        <property type="nucleotide sequence ID" value="XM_003044482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBB4"/>
    <dbReference type="STRING" id="660122.C7ZBB4"/>
    <dbReference type="GeneID" id="9670722"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_22508"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_22508"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_34_14_1"/>
    <dbReference type="InParanoid" id="C7ZBB4"/>
    <dbReference type="OMA" id="KELRWAM"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="14"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="3">
        <location>
            <begin position="301"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="541"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="574"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU38815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="612" mass="69990" checksum="4815160D7697C8C3" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBG9</accession>
    <name>C7ZBG9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_101152</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044448.1">
        <property type="nucleotide sequence ID" value="XM_003044402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBG9"/>
    <dbReference type="STRING" id="660122.C7ZBG9"/>
    <dbReference type="GeneID" id="9672751"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101152"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101152"/>
    <dbReference type="eggNOG" id="KOG0082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051043_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZBG9"/>
    <dbReference type="OMA" id="NDECANI"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU38735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="438" mass="50111" checksum="769BBDFDF131CDB6" modified="2009-10-13" version="1">MASTVALVDEKGLDRMPTDGTAGSSDKGPSDTLPNNDSGNRGWLFPALETVSSYIPIPKASSLTSWYSTEGKQRSDDIDRWLEAEGIRSQRCFRAILLGDRDQTQIFWKQSRLLSEPLSEEEQQSLRSEVRRVFLEEFWNHLTERIDRLEKKRQNAESNESTSNLLEMLQQTLETQDGESDTVQAERLISMCQDSSFQEAFQQERSILEEKDAELLGIEQPKISTCTCDADSFTLSQLQRVFSPNYQATEHDWFHFDHRFPSMVRETQVNMTDYSLAITDVLMNSCRRSRWLHLYDDCACMLFVADISRYWIRIEDVSDYENYDLLKGTIITFESIANSERLSKKPLHLVLSNITAFKAQLTIHPLSESFPEYTGTSDEEAIQFVVKEFLAVVKKREVVNVSTSDITALTGIGKVLDDLEKTVLKPLVEELEDHGVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBK9</accession>
    <name>C7ZBK9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromo shadow domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_55142</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698915">
        <property type="protein sequence ID" value="EEU38589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044302.1">
        <property type="nucleotide sequence ID" value="XM_003044256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBK9"/>
    <dbReference type="STRING" id="660122.C7ZBK9"/>
    <dbReference type="GeneID" id="9670625"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55142"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55142"/>
    <dbReference type="HOGENOM" id="CLU_2948155_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZBK9"/>
    <dbReference type="OrthoDB" id="433924at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008251">
        <property type="entry name" value="Chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01393">
        <property type="entry name" value="Chromo_shadow"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo shadow" evidence="4">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU38589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="60" mass="6790" checksum="262B16FF9E7C5DE2" modified="2009-10-13" version="1" fragment="single">WEDHILTIDGCDEDDTGTLVVYITWCGGQKTKHTASVLYRKCPQKVLQPQLVLISIPSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCZ3</accession>
    <name>C7ZCZ3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Acyl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_84391</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698919">
        <property type="protein sequence ID" value="EEU38004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043717.1">
        <property type="nucleotide sequence ID" value="XM_003043671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCZ3"/>
    <dbReference type="STRING" id="660122.C7ZCZ3"/>
    <dbReference type="GeneID" id="9670205"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84391"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84391"/>
    <dbReference type="eggNOG" id="KOG1469">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_1_2_1"/>
    <dbReference type="InParanoid" id="C7ZCZ3"/>
    <dbReference type="OMA" id="LSYLWTW"/>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF13">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="10">
        <location>
            <begin position="19"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="9">
        <location>
            <begin position="149"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="8">
        <location>
            <begin position="263"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU38004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="50763" checksum="D742549631FCEA9F" modified="2009-10-13" version="1">MEPPASARIPIAFTGQVSNEAKKTLDEVVRFVQEKCIPADAVFAQMLGKTAEKRFAAHPQILEDLKQEAHRRGLWNLFLPKGHYAEGAGYSNLEYGLMAEQLGKSQIASEAMNCSAPDTGNMEVLAKFGNSAQKTAWLEPLLEGKIRSAFLMTEPDVASSDATNIRFDMKRDGDEYILNGSKWWSSGAGDPRCELYIVMGKTDASNPDTYRQQSVILVPTRTPGITVHRMLSVFGYDDAPHGHGHISFNNVRVPSSSIVLGEGRGFEIIQGRLGPGRIHHTMRCIGAAERALDLILSRIHDPSKTPFGKMLHEHGHVITQVAQARIDIDASRLVVLNAAVQIDKGGAKSAIREIAEAKILVPKMLCRILDNAIQIYGGAGVSQDTPLAYMWASARTMRLVDGPDEVHMLQLGRRESRRAEAVRARLKAQKELEQEFFGTYKVDKVDALHMGWTSDTKPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZD76</accession>
    <name>C7ZD76_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_48278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698919">
        <property type="protein sequence ID" value="EEU38174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043887.1">
        <property type="nucleotide sequence ID" value="XM_003043841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZD76"/>
    <dbReference type="GeneID" id="9670043"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_48278"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_48278"/>
    <dbReference type="eggNOG" id="ENOG502SVCB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2133982_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZD76"/>
    <dbReference type="OMA" id="DQWEDAC"/>
    <dbReference type="OrthoDB" id="3873024at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002989169" evidence="1">
        <location>
            <begin position="18"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="108" mass="11731" checksum="BA09232A11A45FEC" modified="2009-10-13" version="1">MLAKTLSVFLFLTLAAADLHDSCTCHNGDSYNWRITTNACTDYNDSKFEWGGAAYDTPSGRCTQITAEDKIAGKEWEAACKKIAQSGFQCADGVGTCYADPDDVRGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDT2</accession>
    <name>C7ZDT2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_54776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043636.1">
        <property type="nucleotide sequence ID" value="XM_003043590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZDT2"/>
    <dbReference type="STRING" id="660122.C7ZDT2"/>
    <dbReference type="GeneID" id="9669737"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_54776"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_54776"/>
    <dbReference type="eggNOG" id="ENOG502T06K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014530_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZDT2"/>
    <dbReference type="OMA" id="GETWFIN"/>
    <dbReference type="OrthoDB" id="10267115at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="784"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="847"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="858"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="868"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="898"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="937"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="952" mass="105908" checksum="1D32D6BB30FE0150" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDY7</accession>
    <name>C7ZDY7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_64899</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043640.1">
        <property type="nucleotide sequence ID" value="XM_003043594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZDY7"/>
    <dbReference type="FunCoup" id="C7ZDY7">
        <property type="interactions" value="208"/>
    </dbReference>
    <dbReference type="GeneID" id="9669478"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_64899"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_64899"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZDY7"/>
    <dbReference type="OMA" id="QHAINEH"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF240">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="241"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU37927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="430" mass="46140" checksum="03B29DF0806865C0" modified="2009-10-13" version="1">MAEGDAQTMRPRGAQPISVQEDNDAQNDEIDYPDGGIKAWMVVVGAWCAMVPPMGLLNTLAVLQAWISENELEGISESKSGWIFSCYAFFITACGAQVGPVFDAYDIKLLLLPGSIGVIASLIFMSLSTEFYHFLLSFGVLGGISSSLLFNPSLSAIGHWFCKRRAFATGLACSAGGIGGIIFSIIILYLTPRIGFPWAIRVVAFLSLGLLIVANVFLRKHIPHNKKAKAYIDFGLFRDVNFSVTVAAIFLVEFAVFIPYTYLCSYALSYGFSSREAYLLNVLLNAGAIPGRVLPGYIADRFGAFNTMIVTALSCGAFILGLWLIADGDHARVMAFSVLFGFWSGAAISLSPVCVSRVCRIEDYGKSNGMAYFVASFGALVGIPIAGALLDGGGDGYRNLIIFAGGFYMVASITFCIARGVAGGWKPALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFL9</accession>
    <name>C7ZFL9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_25618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698923">
        <property type="protein sequence ID" value="EEU37291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043004.1">
        <property type="nucleotide sequence ID" value="XM_003042958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFL9"/>
    <dbReference type="STRING" id="660122.C7ZFL9"/>
    <dbReference type="GeneID" id="9665117"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_25618"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_25618"/>
    <dbReference type="eggNOG" id="ENOG502SNV5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029465_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZFL9"/>
    <dbReference type="OMA" id="ECEIIAT"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU37291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="44895" checksum="D2F45CA6D6189EFC" modified="2009-10-13" version="1" fragment="single">SVMQSPDALRNTMLIAGLHYGWKAGRLQVFESTLLFHKGEAMRLVNWLLVQSDSRRYHECIRHIATLCLTECAFGNVLVAETHLNGLMRYMDFHKPPDSPFADDESVEEELANRYVILTYNFIYGFKSRLRDILHEDDRVPPDTNPDPKRPDPDTVQELMHSWHKDEFRGLDIRLKAMKMVPYFFNQLPPNAKLWDIDGTPMLECLTRITETSGFKRNSAREAIQQNMWLEGAVTRLLLALVGCHIESLSGDYTRGLNRKNRSPLVTSWSGMCSASGLYLHAVLGIWNAGEPIESRMHRRVLYIVKQDLERHRPQKRDRRATDLWLWKAYVCAFSLERHLRLDGDQGLLIPLRRIFGELIAEWSYMTEVTDWTQARNALTRIVWPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHC8</accession>
    <name>C7ZHC8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S33 tripeptidyl aminopeptidase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_23559</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698927">
        <property type="protein sequence ID" value="EEU36749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042462.1">
        <property type="nucleotide sequence ID" value="XM_003042416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHC8"/>
    <dbReference type="GeneID" id="9669540"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_23559"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_23559"/>
    <dbReference type="eggNOG" id="ENOG502RY03">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013364_5_0_1"/>
    <dbReference type="InParanoid" id="C7ZHC8"/>
    <dbReference type="OMA" id="YWPYLAE"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="68"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="4">
        <location>
            <begin position="403"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU36749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="56916" checksum="7F921A4D79D18D13" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHX5</accession>
    <name>C7ZHX5_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_15348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698929">
        <property type="protein sequence ID" value="EEU36356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042069.1">
        <property type="nucleotide sequence ID" value="XM_003042023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHX5"/>
    <dbReference type="GeneID" id="9669069"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_15348"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_15348"/>
    <dbReference type="eggNOG" id="ENOG502SIC9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027146_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZHX5"/>
    <dbReference type="OMA" id="YLIWYPA"/>
    <dbReference type="OrthoDB" id="4360026at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU36356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="353" mass="40140" checksum="3BD185941E271CB2" modified="2009-10-13" version="1" fragment="single">AIRGEAVPQDLSHYVTIRCLVSGIRQHDGFAEELRGKTQHPSILRALNARAIMSNRLPEPNPPTQELPYCFWYPDIPSEQTLRSLLKAYPNPIMPYLVARACAAGGYTELYDELDVLPDVAVAEEARDNKASGQEIYDRIMSAPARYRVMDDYNCTVSLHPKPGALLNGDTRVRSALDKRQPISRDLYPPYFDIAEDWRLGAEGPHPGTRPIPDDVVSLLWNPLPLDLPTVDKDLLILMAAYSGNIDRYARLRRPQLINGEAQCIVRGIYHNTFFAKWCSQQPDLERFRKFVHARFIMNDDLTWVDDIDTSLPQKDLPYTIWYPRLASPETYMELAQRVPVLKQAAAHAMIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZI83</accession>
    <name>C7ZI83_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">nitrilase</fullName>
            <ecNumber evidence="4">3.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_52827</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a nitrile + 2 H2O = a carboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18379"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="EC" id="3.5.5.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.5.1" evidence="4"/>
    <dbReference type="EMBL" id="GG698930">
        <property type="protein sequence ID" value="EEU36214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041927.1">
        <property type="nucleotide sequence ID" value="XM_003041881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZI83"/>
    <dbReference type="STRING" id="660122.C7ZI83"/>
    <dbReference type="GeneID" id="9674341"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_52827"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_52827"/>
    <dbReference type="eggNOG" id="KOG0805">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_6_0_1"/>
    <dbReference type="InParanoid" id="C7ZI83"/>
    <dbReference type="OMA" id="AFMDEYF"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF14">
        <property type="entry name" value="ARYLACETONITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00920">
        <property type="entry name" value="NITRIL_CHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00921">
        <property type="entry name" value="NITRIL_CHT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="6">
        <location>
            <begin position="8"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00036406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU36214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="323" mass="36060" checksum="A1C95DEB0216488E" modified="2009-10-13" version="1">MSSNSSTVKVAAIQAEPVWNDLQGGVAKVISLIQEASGNGANVIGFPEVFIPGYPWSIWANSPTDNAPYMNEYFQNSLERESPEMDRIRDAVREAGVFIVLGYSERYKGTLYIAQSFIDETGTIVHHRRKIKPTHVERAIYGDGQGESLKTVVPSKFGRIGGLNCWEHSQPLLRYYEYSQDVDIHISSWPSIFPQHNPGWPYHIVPETCKNFSNILSQEGACFVVLASQILTEKSKEAANVQGYAYTEKSGGGFSTIFSPFGQELVEPLKPDEEGILYADVDIKEKYKAKQNLDTVGHYSRPDQLSLRVNTHASTPVFFANDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZIJ9</accession>
    <name>C7ZIJ9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_87170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698931">
        <property type="protein sequence ID" value="EEU36037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041750.1">
        <property type="nucleotide sequence ID" value="XM_003041704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZIJ9"/>
    <dbReference type="GeneID" id="9674111"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87170"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87170"/>
    <dbReference type="eggNOG" id="ENOG502RVW2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029465_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZIJ9"/>
    <dbReference type="OMA" id="RYINKWI"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU36037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="589" mass="67341" checksum="E42EC2634F8BD9FB" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJ76</accession>
    <name>C7ZJ76_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_101763</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698932">
        <property type="protein sequence ID" value="EEU36029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041742.1">
        <property type="nucleotide sequence ID" value="XM_003041696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJ76"/>
    <dbReference type="STRING" id="660122.C7ZJ76"/>
    <dbReference type="GeneID" id="9674083"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101763"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101763"/>
    <dbReference type="eggNOG" id="KOG2893">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037132_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZJ76"/>
    <dbReference type="OMA" id="NAFQMQQ"/>
    <dbReference type="OrthoDB" id="1306014at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20908">
        <property type="entry name" value="SUF4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000354">
        <property type="entry name" value="C2H2 finger domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215:SF0">
        <property type="entry name" value="BUB3-INTERACTING AND GLEBS MOTIF-CONTAINING PROTEIN ZNF207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215">
        <property type="entry name" value="ZINC FINGER PROTEIN 207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="9">
        <location>
            <begin position="13"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="171"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU36029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="34268" checksum="9C0EC9D3A4B8946F" modified="2009-10-13" version="1">MGKKRRGHPDIEEILHRPWCYYCERDFEDLKLLISHQKAKHFKCDRCGRRLNTAGGLSVHMNQVHKENLSQVENALPNRQGLEVEIFGMEGIPQDILDQHRNRILQNFQQAQKDRQIATGNPLPGQAMNNPRKKLKVESASELKKRLEEFRARKKDIAANGGVDAAATTTENQATFNAPPYQTSQAPYEQPGYPAQAAPAAQPYGFSPNSLPARPSSGNLPAPPGLPQRPTQGGAWNGAAPAAGDDIDQLIRMAEAGIKPPQKGEGEEGDKKKKDKDKKGRMFYDDAEVSPEERMAALPRYQFTPEVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJ92</accession>
    <name>C7ZJ92_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_35001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698933">
        <property type="protein sequence ID" value="EEU35810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041523.1">
        <property type="nucleotide sequence ID" value="XM_003041477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJ92"/>
    <dbReference type="STRING" id="660122.C7ZJ92"/>
    <dbReference type="GeneID" id="9673948"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_35001"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_35001"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_138_0_1"/>
    <dbReference type="InParanoid" id="C7ZJ92"/>
    <dbReference type="OMA" id="CAWNTIN"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="28"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="228"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU35810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="305" mass="35055" checksum="B1AD40FE6DDAF653" modified="2009-10-13" version="1" fragment="single">MRLIKVASVDSPRGLEMVDFSPNNVPPYAILSHTWTDDEVIYTDVINNTAKQKSSYHKVEYTCRQAIADSYEYAWADNCCIDKRSSAELSEAINSMFEWYSKAERCYAYLTDCPGDFDMTTLDSEFTGSRWFTRGWTLQELVAPKDLIFYGENWVRIGEKRTLSHILSSITGIDEDILINIRPIHSASVAKRMSWAASRETTRPEDVAYSLMGLFNVNMPMLYGEGDRAFLRLQEEIMKQSDDQSIFAWTDRDAPADAHHGLLAKSPTNFKYSNSVVPYEDWEPRTPYSMSNRGLRIDLHLTRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZK65</accession>
    <name>C7ZK65_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_86826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698937">
        <property type="protein sequence ID" value="EEU35588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041301.1">
        <property type="nucleotide sequence ID" value="XM_003041255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZK65"/>
    <dbReference type="GeneID" id="9676005"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86826"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86826"/>
    <dbReference type="eggNOG" id="ENOG502SUYN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079448_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZK65"/>
    <dbReference type="OMA" id="WKWQSSW"/>
    <dbReference type="OrthoDB" id="4367324at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988912" evidence="2">
        <location>
            <begin position="18"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU35588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="309" mass="34822" checksum="04984DDAC0F2229C" modified="2009-10-13" version="1">MTLRIFAVIPFITFPWATPFETLQAILTKANPPIRDESSPPRNVPKSKTAAPDSSFEVIRWTEFNLETLMEAYGDILNEQVQVKNRAPTQLPSIRYLADIKTVAQDCILPTLQYTTEAGARHIGIRLERHLPTFDFRPSLRLPGNQTCYPTFALCSSNDKAHVVGCVQSAKQWHSSDLLGTSMTAKRPIGRLITCCNNANTRYGFVFTSSEVVVTRFSRTNTARPFQIEWQAIPWDAHGENVLTVNLALWLLAMMSLNDDHRPICDSTELLPLNSWSRSVGTDGQVVYQHHLSMRKRFDLPAGAVYTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKR5</accession>
    <name>C7ZKR5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_69902</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698941">
        <property type="protein sequence ID" value="EEU35380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041093.1">
        <property type="nucleotide sequence ID" value="XM_003041047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKR5"/>
    <dbReference type="STRING" id="660122.C7ZKR5"/>
    <dbReference type="GeneID" id="9675546"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_69902"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_69902"/>
    <dbReference type="eggNOG" id="ENOG502SV4E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016775_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZKR5"/>
    <dbReference type="OMA" id="IRSECRM"/>
    <dbReference type="OrthoDB" id="5208775at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="190"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="409"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="515"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="410"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="521"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU35380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="553" mass="61313" checksum="1D38685C0CE010AF" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZL08</accession>
    <name>C7ZL08_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peroxisomal membrane protein PEX16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_36934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peroxin-16 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698942">
        <property type="protein sequence ID" value="EEU35292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041005.1">
        <property type="nucleotide sequence ID" value="XM_003040959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZL08"/>
    <dbReference type="STRING" id="660122.C7ZL08"/>
    <dbReference type="GeneID" id="9675398"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_36934"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_36934"/>
    <dbReference type="eggNOG" id="KOG4546">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036533_2_0_1"/>
    <dbReference type="InParanoid" id="C7ZL08"/>
    <dbReference type="OMA" id="PTWQSTY"/>
    <dbReference type="OrthoDB" id="2021143at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013919">
        <property type="entry name" value="Pex16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08610">
        <property type="entry name" value="Pex16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="2" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU35292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="363" mass="41088" checksum="47E123DEECF1E54C" modified="2009-10-13" version="1">MYDEFITKNAGQVSQIESALRSLTYIIPGRFRDAEIASESIHSGVQLLSLYHDSLLQKAIARLPMASMPSAHARYTRHWTQRSSAYRRIAMFLQMIIYTEMLWEMTAKRRGGERSRWKVVVILEALKALCRLLLLRITRSRPLVTPVLPEREPIPENATAAAEEEELAYRSESELMDDVSANGSDSESTHMKPPHEREWAMPRTGMSLPSLPDAGDISSYLLGRVLTADDIKPATKLLNKLQGSSHGAEILQILSPLIYAAAMAHNSRRGGSKKAWAPWLIGFAVEYAARQLRERGLRTTSLEREEWNKRGWAMGWWAMRGACYENITKGVVGGVSKRMPSFIGGILEDYEYLWENYYFSTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMC5</accession>
    <name>C7ZMC5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7587 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_88411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698951">
        <property type="protein sequence ID" value="EEU34828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040541.1">
        <property type="nucleotide sequence ID" value="XM_003040495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMC5"/>
    <dbReference type="STRING" id="660122.C7ZMC5"/>
    <dbReference type="GeneID" id="9678958"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88411"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88411"/>
    <dbReference type="eggNOG" id="ENOG502SJQX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035446_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZMC5"/>
    <dbReference type="OMA" id="YYEHENR"/>
    <dbReference type="OrthoDB" id="4152607at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056009">
        <property type="entry name" value="DUF7587"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24494">
        <property type="entry name" value="DUF7587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7587" evidence="1">
        <location>
            <begin position="270"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="575" mass="64697" checksum="B963B36B65D372D0" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNU4</accession>
    <name>C7ZNU4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_85544</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039969.1">
        <property type="nucleotide sequence ID" value="XM_003039923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNU4"/>
    <dbReference type="STRING" id="660122.C7ZNU4"/>
    <dbReference type="GeneID" id="9677904"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85544"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85544"/>
    <dbReference type="eggNOG" id="ENOG502SKM2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007003_7_0_1"/>
    <dbReference type="InParanoid" id="C7ZNU4"/>
    <dbReference type="OMA" id="PWYPIVD"/>
    <dbReference type="OrthoDB" id="2154091at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF83">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="373"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU34256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="726" mass="80495" checksum="822A8A9B714FD43A" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZP37</accession>
    <name>C7ZP37_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_101803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039992.1">
        <property type="nucleotide sequence ID" value="XM_003039946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZP37"/>
    <dbReference type="GeneID" id="9677927"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101803"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101803"/>
    <dbReference type="eggNOG" id="ENOG502SP0F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_565233_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZP37"/>
    <dbReference type="OMA" id="ERRMQNC"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF5">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU34279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="429" mass="47800" checksum="7A1E87D02CF9D830" modified="2009-10-13" version="1">MVSGQDNIGRSSSTNHVARKQTSTERRIQNRKAQKAYRERKRQRLQELENKVHALESASFIQPSTPQSISNLDTTPSHNIDASLGLLGDALNGDSAHEFSSTAAGLTEASAWTDADMWLDPAQLDGNFETDNVSNDTEELSLLRPNPTPVYQSSITQNTPLSTDGKAIQVSRPGGNMMSFSPRVLREVYTSLPKTTRDELRELAKAGDFSFVDVIKSRLGSGNNLSSQSPRQRTLESSTYCPYRNVMHIARFSYFAALFANLSSLGFDFSLFLNETSVSPFVGRSDLGDTDVPFSLRPLASQRSISHHPYIDSLPFPEFRRRALAALSTDPPLLDEDDLCIDLMLNDGLVCWGSMSENGMDRGTPWDSRSWEAKGWFLRKWWWLVGGQDGELWQSSTWWASQRGEKISTRERNTEGKDIAVGVYVGGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPD0</accession>
    <name>C7ZPD0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_50158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039834.1">
        <property type="nucleotide sequence ID" value="XM_003039788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZPD0"/>
    <dbReference type="GeneID" id="9677775"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_50158"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_50158"/>
    <dbReference type="eggNOG" id="ENOG502SMA1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062358_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZPD0"/>
    <dbReference type="OMA" id="FIDYQDC"/>
    <dbReference type="OrthoDB" id="71437at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046312">
        <property type="entry name" value="DUF6454"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20055">
        <property type="entry name" value="DUF6454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU34121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="35165" checksum="E33DFCCB8C6C4776" modified="2009-10-13" version="1">MEEPLAPTPLPPAHAASDGEQIIHIFQTLGRSTVWKSIANITFEGDTFEPEGMVRLGDDRYVVSSGHWTEPTEKYGKIINGTDRTPGKGLAHLMVYNGKGKLVADATITKEGDDEYHNGGIDFDGQYIWGTIAQYRPNSTAYVYRTDPNTLVLERVLNYADHLGGVVHDTRDNLITALNWGGRNASTWDLKSAETGCDASPEPERVVRNPSYFVDYQDCKWLGHSRFYNGKSIMLCSGVATIGGYNLGGIALVDVATMTPLAEIPIDLESALGVRLTQNPMDVGVKDGKLRLYLMPDQHNSTLYIYEAQPESPFQYGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPR9</accession>
    <name>C7ZPR9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_55800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698971">
        <property type="protein sequence ID" value="EEU33991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039704.1">
        <property type="nucleotide sequence ID" value="XM_003039658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZPR9"/>
    <dbReference type="GeneID" id="9677527"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55800"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55800"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_6_1_1"/>
    <dbReference type="InParanoid" id="C7ZPR9"/>
    <dbReference type="OMA" id="VFTHFIN"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF1">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU33991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="524" mass="56298" checksum="B16C9E14E0A655E3" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQC8</accession>
    <name>C7ZQC8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenosine deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_17307</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GG698988">
        <property type="protein sequence ID" value="EEU33779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039492.1">
        <property type="nucleotide sequence ID" value="XM_003039446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQC8"/>
    <dbReference type="STRING" id="660122.C7ZQC8"/>
    <dbReference type="GeneID" id="9667013"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_17307"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_17307"/>
    <dbReference type="eggNOG" id="KOG1097">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039228_7_0_1"/>
    <dbReference type="InParanoid" id="C7ZQC8"/>
    <dbReference type="OMA" id="YIATFEH"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016814">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114">
        <property type="entry name" value="ADENINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114:SF6">
        <property type="entry name" value="ADENINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="5">
        <location>
            <begin position="6"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU33779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="332" mass="36970" checksum="55F94719103CF0E5" modified="2009-10-13" version="1" fragment="single">WLQGLPKAELHLHLEGTVTPETLITLSVRHDSTPLTLQQARELYAYRDFVHFLHTFRLVLDRLQTPEDYALIVKEMMRNLHDQGVVHAEVYISWGNILHRKPHLDIEDVMAAIELARTEVLRDLGGPSIFWIADANRAWSVQEAGQVFGLAGKLKERFPTIVGIGLGGDEVGGPVEWFEQVYADAKKAGLRLTAHVGEATGPERGPSQIRTALKMGVERIGHGLAAQHDESLMHFLSKQNLPVEINITSNILTGCCPSVEVHPLPKYLEKGMFCILNSDDPAMFGSTCLDEYVLASDVFSLDLEAMRGLARNSITASFLPEKTKTQFLSRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZRH0</accession>
    <name>C7ZRH0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_73318</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG699083">
        <property type="protein sequence ID" value="EEU33388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039101.1">
        <property type="nucleotide sequence ID" value="XM_003039055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZRH0"/>
    <dbReference type="GeneID" id="9666622"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_73318"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_73318"/>
    <dbReference type="eggNOG" id="KOG1205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_8_2_1"/>
    <dbReference type="InParanoid" id="C7ZRH0"/>
    <dbReference type="OMA" id="PASYCVW"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="3">
        <location>
            <begin position="28"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU33388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="287" mass="30664" checksum="2CC50BEF0B452DAF" modified="2009-10-13" version="1">MSTPTTVYHRRAYPAIDPKRPELSTKGKNVVVTGSGSGIGAEIAKAFARSGAANVALVGRTAATLQSTKIAIEKESPETSVHIITADLTDAGHISEALATFTQAVPRGTIDVLVANAGYLHALVQLADLEHDDFWRTFEINVKGNFNLLRAFRTYAAVNATVISVNSAVAHVGFLPGHSGYAAAKAASAKMFDYFRAENPGIRVVQFHPGVVMTEMASKSVDAGTDLPFDDVSLPAAFAVWSASPEAGFLNGKYVWPHWDVDELKVMSSEIEESDRFTIGLGLSARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7YGU4</accession>
    <name>C7YGU4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Luciferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_74743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053515.1">
        <property type="nucleotide sequence ID" value="XM_003053469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YGU4"/>
    <dbReference type="GeneID" id="9664314"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74743"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74743"/>
    <dbReference type="eggNOG" id="ENOG502S0WG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063954_1_1_1"/>
    <dbReference type="InParanoid" id="C7YGU4"/>
    <dbReference type="OMA" id="EICHAHP"/>
    <dbReference type="OrthoDB" id="9987011at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048273">
        <property type="entry name" value="Luciferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040841">
        <property type="entry name" value="Luciferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38695">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38695:SF1">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17648">
        <property type="entry name" value="Luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase" evidence="1">
        <location>
            <begin position="209"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU47802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="303" mass="33901" checksum="475BAAD3B0F49D26" modified="2009-10-13" version="1">MSIAITSAETLTSPPPDLQGEVEVEALNISCVLRQQPISVTLDGPTIFLSALALLLVVHFLEPYHAELLIGIVPLVLLIQNDYQNFLNLGPGGTPSTFAGYIRITWFRLWSLNDPFVPPVPDPTRLPTSGILNRYHLPYRAGPRPIVAGIAPQRQIDQHGSQGCYRAVRRSMEKLASRIPKKFGTERSCLEKHGLALFARHPLQTNCQGEIVHVHDSDHSMHMCLHPDDIKEVLDKGWGQRHPLAWRSRFLKSPVSPDFVMIYAPRASQLDDEELQVICNVIEAAIWYTVAEDIEITTPLKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHZ7</accession>
    <name>C7YHZ7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spore coat protein SP96</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_103191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053715.1">
        <property type="nucleotide sequence ID" value="XM_003053669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YHZ7"/>
    <dbReference type="STRING" id="660122.C7YHZ7"/>
    <dbReference type="GeneID" id="9674738"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_103191"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_103191"/>
    <dbReference type="eggNOG" id="ENOG502RYN9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032571_1_1_1"/>
    <dbReference type="InParanoid" id="C7YHZ7"/>
    <dbReference type="OMA" id="YGHMQLA"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988317" description="Spore coat protein SP96" evidence="2">
        <location>
            <begin position="22"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU48002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="45838" checksum="DD3FE9B39A17AC1A" modified="2009-10-13" version="1">MKFFGIESAALALGLAGLAQAHMEMTSPPPFKSKANPHANGDVDYSMTAPLEAGGGNFPCKGYHSLFGTPAGASVADWKAGGSYSMTITGGANHGGGSCQASLSFDKGETWKVIHSYVGNCPGAGTTSYDFKVPADTPSGEAIFAWTWFNQIGNREMYMNCAAVTIGGGSSKKRASALSSRPSMFVANVNNGCSTEEGSDLEFPDPGPDTSNDSSKTAPPKGSCASSSGSGGGSSGGDSGATPSSPAGDVGSGNGNNGAVPSSPADNGSGAPSSAPVSAPTQTQPAAEPSQPAAEPTQPAVESSAPAGGAPSQVPGGVFITVSPPAEGTEAPVAAPTDTMMTLTKSAPGTGNEPMPTSVVQPEPVPTTPAGTPEAAPTVPATPSSGSGDGGSDSGSGSGEAHTAGTACTSEGEWNCIGGSKYQRCASGRWSVVQSMASGTTCSGSKAMAFAWGFGRKLALRARRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7YI22</accession>
    <name>C7YI22_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit</fullName>
            <ecNumber evidence="3">2.4.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GlcNAc-PI synthesis protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_90275</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.198" evidence="3"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053730.1">
        <property type="nucleotide sequence ID" value="XM_003053684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YI22"/>
    <dbReference type="FunCoup" id="C7YI22">
        <property type="interactions" value="474"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YI22"/>
    <dbReference type="GeneID" id="9664752"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90275"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90275"/>
    <dbReference type="eggNOG" id="KOG1111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_19_2_1"/>
    <dbReference type="InParanoid" id="C7YI22"/>
    <dbReference type="OMA" id="SHFWMSG"/>
    <dbReference type="OrthoDB" id="734129at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03796">
        <property type="entry name" value="GT4_PIG-A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000053">
        <property type="entry name" value="Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000026">
        <property type="entry name" value="Phosphatidylinositol N-acetylglucosaminyltransferase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039507">
        <property type="entry name" value="PIG-A/GPI3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013234">
        <property type="entry name" value="PIGA_GPI_anchor_biosynthesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08288">
        <property type="entry name" value="PIGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIGA GPI anchor biosynthesis" evidence="11">
        <location>
            <begin position="45"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="10">
        <location>
            <begin position="224"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="473"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="488"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU48017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="500" mass="56119" checksum="25FD5BF285E85B28" modified="2009-10-13" version="1">MTRRTYNIAMVSDFFFPQPGGIESHIYQLATKLVDRGHKVIVITHAYDDRKGVRYLTNGVKVYHVPFLEIYRHATFPTVFSFFPIFRNICIRERIEIVHGHGSLSSLCHEAILHARTMGLRTAFTDHSLFGFADAGTILTNKLLKFTLSDVDHSICVSHTCKENTVLRASLDPLMVSVIPNAVVAENFRPKDTPASPSPQSTTFGSEAPVYPPPQRIGPRDIITIVVISRLFYNKGTDLLIASIPRVLENHPNTRFIIAGSGPKAIDLEQMIETNVLQDRVEMLGPIRHEEVRDVMVRGHIYLHPSLTEAFGTVIVEAASCGLYVVCTQVGGIPEVLPSHMTTFAKPEEDDIVLATGKAITAIRAGKIRTEKFHDQVKKMYSWQNVALRTERVYDGISGTIPEDEFYGIDTSGYGSRIRNFALIDRLKRYYGCGIWAGKLFCLCCVVDYLFFLFLEWWFPRDNIDICPDWPRKQPAEDGAGSKKGLHSNRSSTSQGAPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIN9</accession>
    <name>C7YIN9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_102396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053841.1">
        <property type="nucleotide sequence ID" value="XM_003053795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIN9"/>
    <dbReference type="GeneID" id="9664673"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102396"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102396"/>
    <dbReference type="eggNOG" id="ENOG502SNJR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_4_3_1"/>
    <dbReference type="InParanoid" id="C7YIN9"/>
    <dbReference type="OMA" id="MDSYKIA"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03038">
        <property type="entry name" value="GST_N_etherase_LigE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="20"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Glutathione S-transferase UstS-like C-terminal" evidence="2">
        <location>
            <begin position="111"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU48128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="241" mass="27642" checksum="654159EDA3FFBF4F" modified="2009-10-13" version="1">MSSDQTVLFDLPSKAPRAAWSLNPWKTRFLLNFKGIDYKTEWLEYPNIKPTLEPHVSANEATGTWTIPTVKFPDGTYLMDSRKIVERVEKEHPEPSIHLDSPILAKLEEIMPRIMGPLRPIYFTTVPERLLNEESVPYWHETRSKLAGMPLDQLNKEKGGQIAWDAAKPVIAEVEALLKENSEGPFFLGKTPSYADFVWAGFLIFMQRNQVIDDLYNVSGDSQLHKDLLEATAPWHKRNDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIW6</accession>
    <name>C7YIW6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_30592</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053880.1">
        <property type="nucleotide sequence ID" value="XM_003053834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIW6"/>
    <dbReference type="FunCoup" id="C7YIW6">
        <property type="interactions" value="527"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YIW6"/>
    <dbReference type="GeneID" id="9664712"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_30592"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_30592"/>
    <dbReference type="eggNOG" id="KOG3662">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011607_2_1_1"/>
    <dbReference type="InParanoid" id="C7YIW6"/>
    <dbReference type="OMA" id="TIQNHLC"/>
    <dbReference type="OrthoDB" id="5977743at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF4">
        <property type="entry name" value="METALLOPHOSPHOESTERASE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="576"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="602"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU48167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="695" mass="78488" checksum="96B1AB361819F01D" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJB1</accession>
    <name>C7YJB1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Glycosyltransferase family 71</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_75617</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054662.1">
        <property type="nucleotide sequence ID" value="XM_003054616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJB1"/>
    <dbReference type="FunCoup" id="C7YJB1">
        <property type="interactions" value="93"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YJB1"/>
    <dbReference type="GeneID" id="9676583"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75617"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75617"/>
    <dbReference type="eggNOG" id="ENOG502RZ48">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030430_1_0_1"/>
    <dbReference type="InParanoid" id="C7YJB1"/>
    <dbReference type="OMA" id="SHYEKVI"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000033">
        <property type="term" value="F:alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392:SF1">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU48949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="58152" checksum="B32D19C36782F767" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJI2</accession>
    <name>C7YJI2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_75687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054691.1">
        <property type="nucleotide sequence ID" value="XM_003054645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJI2"/>
    <dbReference type="GeneID" id="9663852"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75687"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75687"/>
    <dbReference type="HOGENOM" id="CLU_1669850_0_0_1"/>
    <dbReference type="InParanoid" id="C7YJI2"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988359" evidence="1">
        <location>
            <begin position="24"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU48978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="158" mass="17041" checksum="1FF7CA8721FF8E93" modified="2009-10-13" version="1">MGLLLLLRCAALLLLLLLYRGLCTEYVLDEGLGDLSGGTRGEEPSVEAGSPETPCLALSRLLSTPASRLGEGGWVPAGLFQRSVEWGAAFSVDSAGSAVGDWRLASSSGRQRDVVPEKPCPYHEKPSTSLKRLDVWRRDMESGETGRARGQSLRSPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJI7</accession>
    <name>C7YJI7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_90539</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054694.1">
        <property type="nucleotide sequence ID" value="XM_003054648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJI7"/>
    <dbReference type="GeneID" id="9676615"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90539"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90539"/>
    <dbReference type="eggNOG" id="ENOG502SMKE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004083_8_0_1"/>
    <dbReference type="InParanoid" id="C7YJI7"/>
    <dbReference type="OMA" id="EVCIRQK"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF57">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="77"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="330"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="565"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="350"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="569"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU48981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="608" mass="68903" checksum="FB725C5A8A1EF233" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7YKL1</accession>
    <name>C7YKL1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIF subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TFIIF medium subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">TFIIF-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_74647</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053471.1">
        <property type="nucleotide sequence ID" value="XM_003053425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YKL1"/>
    <dbReference type="FunCoup" id="C7YKL1">
        <property type="interactions" value="505"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YKL1"/>
    <dbReference type="GeneID" id="9664189"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74647"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74647"/>
    <dbReference type="eggNOG" id="KOG2905">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047858_0_2_1"/>
    <dbReference type="InParanoid" id="C7YKL1"/>
    <dbReference type="OMA" id="ANCPEHQ"/>
    <dbReference type="OrthoDB" id="26094at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07980">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000035">
        <property type="entry name" value="General transcription factor IIF subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003196">
        <property type="entry name" value="TFIIF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040504">
        <property type="entry name" value="TFIIF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17683">
        <property type="entry name" value="TFIIF_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIF beta subunit N-terminal" evidence="12">
        <location>
            <begin position="51"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="11">
        <location>
            <begin position="275"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="152"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="341"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="353"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU47758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="369" mass="42475" checksum="2A4C24EB36174745" modified="2009-10-13" version="1">MTEPYIKSEGYIKPDPESSGSPAQMDEDDLYEDAGDLEFFDKNAANRAFETLYLARVPRYMWDAWIKLTERLGDDDEIRIGTLRTWTEQKPDGSANTKLRMLLSDQCPEHQMLPREYDLEVLEPNVNNHFIFSEEDLPGYKAQNKARHEAVNAGIPNSLLRKPNNNGGSDRPSYDRRSRYQPYYRKAVPKRTKVFGKIHYDVRVEPRDVREEERLLAQRLQDAEQSKSKLKIISRNKASSIINPGATGSASWGGNFIKNTAPINKPKKGEVFKAARIPENQLLDLIFECFRQYQYWSMKALRQKLQQPDQYLRQVLEKIAVLNKSGRFANHYCLSDAYRDKGGAESKEAAAEPIDDDDDEEMEDVLPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C7YKM0</accession>
    <name>C7YKM0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdenum cofactor sulfurase</fullName>
            <shortName evidence="4">MCS</shortName>
            <shortName evidence="4">MOS</shortName>
            <shortName evidence="4">MoCo sulfurase</shortName>
            <ecNumber evidence="4">2.8.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Molybdenum cofactor sulfurtransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hxB</name>
        <name evidence="7" type="ORF">NECHADRAFT_90012</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:42636"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:82685"/>
            <dbReference type="EC" id="2.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.9" evidence="4"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054187.1">
        <property type="nucleotide sequence ID" value="XM_003054141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YKM0"/>
    <dbReference type="STRING" id="660122.C7YKM0"/>
    <dbReference type="GeneID" id="9676808"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90012"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90012"/>
    <dbReference type="eggNOG" id="KOG2142">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010913_0_0_1"/>
    <dbReference type="InParanoid" id="C7YKM0"/>
    <dbReference type="OMA" id="PCTRCQM"/>
    <dbReference type="OrthoDB" id="10264306at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008265">
        <property type="term" value="F:molybdenum cofactor sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03050">
        <property type="entry name" value="MOCOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028886">
        <property type="entry name" value="MoCo_sulfurase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF80">
        <property type="entry name" value="MOLYBDENUM COFACTOR SULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MOSC" evidence="6">
        <location>
            <begin position="604"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="568"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU48474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="775" mass="86304" checksum="A9E1E3BD9E2489FB" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7YKN7</accession>
    <name>C7YKN7_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_74672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054195.1">
        <property type="nucleotide sequence ID" value="XM_003054149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YKN7"/>
    <dbReference type="STRING" id="660122.C7YKN7"/>
    <dbReference type="GeneID" id="9676817"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74672"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74672"/>
    <dbReference type="eggNOG" id="ENOG502R8BV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021363_0_0_1"/>
    <dbReference type="InParanoid" id="C7YKN7"/>
    <dbReference type="OMA" id="GYACSFY"/>
    <dbReference type="OrthoDB" id="5244801at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU48482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="536" mass="59103" checksum="4DECE2FEA6C2EE85" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7YKR5</accession>
    <name>C7YKR5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pyridoxal kinase</fullName>
            <ecNumber evidence="2">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_98769</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="2"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054210.1">
        <property type="nucleotide sequence ID" value="XM_003054164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YKR5"/>
    <dbReference type="FunCoup" id="C7YKR5">
        <property type="interactions" value="419"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YKR5"/>
    <dbReference type="GeneID" id="9676830"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_98769"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98769"/>
    <dbReference type="eggNOG" id="KOG2599">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046496_0_0_1"/>
    <dbReference type="InParanoid" id="C7YKR5"/>
    <dbReference type="OMA" id="AWTHQHP"/>
    <dbReference type="OrthoDB" id="2104723at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00687">
        <property type="entry name" value="pyridox_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534:SF2">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="7">
        <location>
            <begin position="117"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU48497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="372" mass="41293" checksum="F2426642977EFEBC" modified="2009-10-13" version="1">MSDTLPVPDTRVLAVASHVVSGYVGNKIAVFVLQSLGCDVAALNTVQFSNHTGYKQWKGTRVSAQEIMELYEGLKQSYLDDFDMMLSGYIPGAEAVNTVGQIGRELKQKAAETPGKFFWVLDPVMGDNGRLYVSEEVVPAYKKLLHDADLILPNQFEAELLSECKIHDMDSLHKAIQAMHDKYRVPHIVITSVNLEAPDHPPSHLSVVGSSMTSTGKARFFKIVFPSIDCYFSGTGDMFGALMVIRMREAVYNANGSLRNTASWLSDDSVSAVDLPLARAAEKVLASMHEVLSKTCEGMRGVVDRTLTEMRPQDRANDTKVHLVKSKAAELQLNKRNRRVLKSAYLLFLFESICEYPRGILIHIPYQPSLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7YKX9</accession>
    <name>C7YKX9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_36240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052410.1">
        <property type="nucleotide sequence ID" value="XM_003052364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YKX9"/>
    <dbReference type="STRING" id="660122.C7YKX9"/>
    <dbReference type="GeneID" id="9670942"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_36240"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_36240"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="InParanoid" id="C7YKX9"/>
    <dbReference type="OMA" id="LWNSQHH"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="18"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU46697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="340" mass="37807" checksum="6352566D2D460E4C" modified="2009-10-13" version="1">MSLGRTVLLNSGHKIPQLGYGTWQSSPGEVALGVFEALKVGYRHLVTNVICRYGNQPEVAEGLKRAFKEIPGLRREDVFITSKLWNSQHDPEIVEAALDDCLEELGLEYLDLYLVHFPISFKKSSVHVGQDLFPLTGGNQPEGDVVIDDTISIVDTWRAMTKLPKSKARAIGVSNHTVEHLKAIIDGTSVVPAVNQIERHPLLRQDDLIAFCKEKNIHITAYSAFGNNMLNIPLLFSHPDIKSLAERLSRERGQEVTPTQVLLSWAQSGGHSVIPKSVTPARIAANFEEIDLSADDLRVVEGVGKEQRRFNIPYIANKPRWDINLFGDESEAPATHKIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C7YN02</accession>
    <name>C7YN02_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_78059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052751.1">
        <property type="nucleotide sequence ID" value="XM_003052705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YN02"/>
    <dbReference type="GeneID" id="9664242"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78059"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78059"/>
    <dbReference type="HOGENOM" id="CLU_717823_0_0_1"/>
    <dbReference type="InParanoid" id="C7YN02"/>
    <dbReference type="OrthoDB" id="5096238at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU47038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="385" mass="43034" checksum="260E9C5D465F0402" modified="2009-10-13" version="1">MGNNHDNRGGYNGRGRNRRGWNKGGRNNGWQNEGNQQNGNNQNNGNNQQNGNNQHNGYSHYNGNHQQNQQNQRNGNNQNNGNNQSNGNNQNNGNNQSNGNNQNNGSNQQNGNSQQNGNNQQNGNLANNGQKNSKCSNDTIHWKTNGWIGADSNNTDDDNNNNGHNDNHCCFWQEVSQNPFLRQITAQLSQFMANNKRTFYPNSPPPSIDAIMTEARQAKTDWRKKVDGIQGAQVLLETKIGNFIGQALHGYFSPCMNPDILDETYMMTEQDVDAPASQCVGKYTVHSRHPIIPNGPKELEVQIKVTKSTMRVEMLVCPRDTDGYNFVGPVGAMNWYQKTLVTPIEGYTVTGQIDQGPKGMYLALIMGQSERAWDYVYANLLKCPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNT6</accession>
    <name>C7YNT6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">S-formylglutathione hydrolase</fullName>
            <ecNumber evidence="2 7">3.1.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_102591</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Serine hydrolase involved in the detoxification of formaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-formylglutathione + H2O = formate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14961"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="3.1.2.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the esterase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.12" evidence="2 7"/>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051887.1">
        <property type="nucleotide sequence ID" value="XM_003051841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNT6"/>
    <dbReference type="FunCoup" id="C7YNT6">
        <property type="interactions" value="706"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YNT6"/>
    <dbReference type="ESTHER" id="nech7-c7ynt6">
        <property type="family name" value="A85-EsteraseD-FGH"/>
    </dbReference>
    <dbReference type="GeneID" id="9672966"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102591"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102591"/>
    <dbReference type="eggNOG" id="KOG3101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056472_0_1_1"/>
    <dbReference type="InParanoid" id="C7YNT6"/>
    <dbReference type="OMA" id="PSDCPWG"/>
    <dbReference type="OrthoDB" id="420518at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018738">
        <property type="term" value="F:S-formylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000002">
        <property type="entry name" value="S-formylglutathione hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014186">
        <property type="entry name" value="S-formylglutathione_hydrol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02821">
        <property type="entry name" value="fghA_ester_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061:SF0">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0719">Serine esterase</keyword>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR614186-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU46174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="285" mass="31178" checksum="0C434F132B176233" modified="2009-10-13" version="1">MAFTTNATITSFGGRFLKLTHQSSVTGTPMNATLYLPPSASASKPAPLLIYLSGLTCSPDNVTEKGFLHAHASSLGLALLYPDTSPRGLDLPGEHDSWDFGSAAGFYIDATKDPWSKNYNMESYVSKELHDLVFQEFKELDSSRVSISGHSMGGHGALTLFLKNPGKYKSVSAWAPISNPSKCPWGDKAFSGYFGDDKEEWKKHDATELVKSWKGHFPALIDVGTADNFYKAGQLLPENLEKAVKEAGIEGLNVRYRDGYDHSYFFISTFGEDHVKHAAKALGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNW0</accession>
    <name>C7YNW0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GPI anchored serine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_100241</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051897.1">
        <property type="nucleotide sequence ID" value="XM_003051851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNW0"/>
    <dbReference type="STRING" id="660122.C7YNW0"/>
    <dbReference type="GeneID" id="9670880"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100241"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100241"/>
    <dbReference type="eggNOG" id="ENOG502SGJX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067145_0_0_1"/>
    <dbReference type="InParanoid" id="C7YNW0"/>
    <dbReference type="OMA" id="TVTCHES"/>
    <dbReference type="OrthoDB" id="3565477at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988434" description="GPI anchored serine-rich protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU46184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="36317" checksum="5630D8A4B9B420BD" modified="2009-10-13" version="1">MRYAFAAAFLASSAMATKDVVYQTELVTITSCGPEVTNCPARSTVVSTTSYPVVETSEAPIPTYEAPEPTYEAPKPTYEAPKPTSEAPLTTSTIYSTNIKTITSCGPEVTNCPARSTVVTTETYAVSTTICPVGEPSKPAQPEKPEQPTKPVYEQPKPSKPAETKPVYEQPSKPVYEQPSKPVYEQPSKPVYEQPSQPATPGKPTYPGKPSQPAPHHNGTVPVYPNPPAESSNKPVVPATPVPEAPECVPSQSVTAITKSYTTVLTTVEYSTIQVPCPTGGNPGYPSQPGNPTGPAVPPPAATTPAGGNPPAHGNETVPTQPPAVTAGAATFAGSAFFAAAAGIAAFILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7YP80</accession>
    <name>C7YP80_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Eukaryotic translation initiation factor 2A</fullName>
            <shortName evidence="8">eIF-2A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_68033</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051963.1">
        <property type="nucleotide sequence ID" value="XM_003051917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YP80"/>
    <dbReference type="FunCoup" id="C7YP80">
        <property type="interactions" value="1211"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YP80"/>
    <dbReference type="GeneID" id="9668590"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_68033"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_68033"/>
    <dbReference type="eggNOG" id="KOG2315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013809_0_1_1"/>
    <dbReference type="InParanoid" id="C7YP80"/>
    <dbReference type="OMA" id="RCCAYSP"/>
    <dbReference type="OrthoDB" id="2194683at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000596">
        <property type="entry name" value="Eukaryotic translation initiation factor 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="10">
        <location>
            <begin position="217"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="479"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="602"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="613"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU46250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="685" mass="74402" checksum="9CC2C12500D65E6A" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPP5</accession>
    <name>C7YPP5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Life-span regulatory factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_102533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051600.1">
        <property type="nucleotide sequence ID" value="XM_003051554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YPP5"/>
    <dbReference type="GeneID" id="9668753"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102533"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102533"/>
    <dbReference type="eggNOG" id="ENOG502S7ZU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099513_1_0_1"/>
    <dbReference type="InParanoid" id="C7YPP5"/>
    <dbReference type="OMA" id="CLVCDRQ"/>
    <dbReference type="OrthoDB" id="2563506at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024368">
        <property type="entry name" value="Ecl1/2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12855">
        <property type="entry name" value="Ecl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU45887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17130" checksum="AD00827CA51E7A1F" modified="2009-10-13" version="1">MDFDSWSHSFCLACDKQVQTSTDAYCSESCRLADFEKTSTTSSQASSPGFAPPSYPWTSKASSPGFYLSPAYDFSNAKPYGARHMSQPNCKPYGTEQSTANVRSLTPSSSHSSLCSMQSTSTTGESTQLSDKARKELRAYAVSFEQVRMQRRRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQ32</accession>
    <name>C7YQ32_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arp2/3 complex 34 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_60055</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052112.1">
        <property type="nucleotide sequence ID" value="XM_003052066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQ32"/>
    <dbReference type="FunCoup" id="C7YQ32">
        <property type="interactions" value="774"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YQ32"/>
    <dbReference type="GeneID" id="9673415"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_60055"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_60055"/>
    <dbReference type="eggNOG" id="KOG2826">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059439_1_0_1"/>
    <dbReference type="InParanoid" id="C7YQ32"/>
    <dbReference type="OMA" id="FRSYFHY"/>
    <dbReference type="OrthoDB" id="148331at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072697">
        <property type="term" value="P:protein localization to cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000003">
        <property type="entry name" value="Arp2/3 complex 34 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000005">
        <property type="entry name" value="Arp2/3 complex 34 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007188">
        <property type="entry name" value="ARPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058">
        <property type="entry name" value="ARP2/3 COMPLEX 34 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04045">
        <property type="entry name" value="P34-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU46399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="319" mass="36525" checksum="B812B8334316B483" modified="2009-10-13" version="1">MLLLDYQNVLIQSVLTERFSGAPPASIDQTVSDFDGVTFHISTPETKTQILLSIQIRCFPDLVKYGAEEVLQREYGDYVAPVEPGFDFSVLVDLENLPESKEERDALALKFALLKRNAMAAPFEQAYQEHYALKEEASKFTSEEAPQGVQEGGEVKAIHYREEEAIYVKASHDRVTVIFSTVFREETDRVFGKVFIQEFVDARRRAIQNAPQVLFRNDAPLELQGVPGIQNTDSGDIGYVTFVLFPRHLTPQRMGDVISHIQTFRDYFHYHIKASKAYIHSRMRKRTADFLQVLRRARPENEEKERKTASGRTFKVQGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQT3</accession>
    <name>C7YQT3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">6-phosphogluconolactonase</fullName>
            <shortName evidence="6">6PGL</shortName>
            <ecNumber evidence="4 6">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_79217</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="4 6"/>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052240.1">
        <property type="nucleotide sequence ID" value="XM_003052194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQT3"/>
    <dbReference type="FunCoup" id="C7YQT3">
        <property type="interactions" value="294"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YQT3"/>
    <dbReference type="GeneID" id="9672702"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79217"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79217"/>
    <dbReference type="eggNOG" id="KOG3147">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053947_0_1_1"/>
    <dbReference type="InParanoid" id="C7YQT3"/>
    <dbReference type="OMA" id="YQLFEFE"/>
    <dbReference type="OrthoDB" id="432544at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000005">
        <property type="entry name" value="6-phosphogluconolactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF0">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="7">
        <location>
            <begin position="14"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU46527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="260" mass="28228" checksum="12BE5B52F89E8CDE" modified="2009-10-13" version="1">MAKTQPNLFAFPSVDVLAQALRSYVIQSQAAGIARHGAFKVAVSGGSLPKTLAQALLAPSSGSNDVVDFARWEIFFADERAVPLDHDDSNYALLKKELLDKIPEGQKPTVHTINTEHLNDLQELADEYEQTLVASFASRDSVRLPIFDLLLLGCGPDGHTCSLFPGHPLLRETSAWVAPIDDSPKPPPKRITLTLPVVNHAVRVAFVATGGGKKDIMKQIFDTNGGLPCTLVNESTGERCSWFVDEPAVEGVSFPRRAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7YR39</accession>
    <name>C7YR39_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CTP:phosphocholine cytidylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phosphorylcholine transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_100466</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="9"/>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051102.1">
        <property type="nucleotide sequence ID" value="XM_003051056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YR39"/>
    <dbReference type="STRING" id="660122.C7YR39"/>
    <dbReference type="GeneID" id="9666496"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100466"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100466"/>
    <dbReference type="eggNOG" id="KOG2804">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034585_5_2_1"/>
    <dbReference type="InParanoid" id="C7YR39"/>
    <dbReference type="OMA" id="IPDCPWI"/>
    <dbReference type="OrthoDB" id="17102at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042564">
        <property type="term" value="C:NLS-dependent protein nuclear import complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000147">
        <property type="entry name" value="Cholinephosphate cytidylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="13">
        <location>
            <begin position="159"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="352"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="406"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="440"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU45389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="456" mass="49867" checksum="28FF4FED3B4C1947" modified="2009-10-13" version="1">MSSPSGSSQGGKRKRVSLSRPDSSVDLLDNGIQTSSRDASGEEGDTTAAEDGRPHHRAAAVSGPIPKRQRSNSDRIIENTDHALDPGEPSDTTEASIDIAERVGRKARKPSLRDLDDDDDEGEIHATEAMPPPPIGKLTDPAGGYKTNPPPVGRAVRVYADGVFDLLHLGHMRQLEQAKKAFPNTTLVVGVTGDHETHKRKGLTVMSAAERSETLRHCKWVDEVIEDCPWIVTPEFLEEHKLDYVAHDDLPYGADEGDDIYQPIKAAGKFLVTQRTEGVSTTGLITRIVRDYEKYIARQFKRGTSRQELNVSWLKKNEMDLKRHVQDLRENITNNWTTTGQELGRELKQFWPTSRPQSPARFNSAGSAEQLRSPTTPGGGSGTPKEFITGYALGLVGGVRSWMTKSRRDAADGSRPVSDDESEESDNIANANANANANAKTSTDPAINTPTTTSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRR9</accession>
    <name>C7YRR9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_93654</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051223.1">
        <property type="nucleotide sequence ID" value="XM_003051177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YRR9"/>
    <dbReference type="STRING" id="660122.C7YRR9"/>
    <dbReference type="GeneID" id="9667994"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_93654"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_93654"/>
    <dbReference type="eggNOG" id="KOG4400">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023950_0_0_1"/>
    <dbReference type="InParanoid" id="C7YRR9"/>
    <dbReference type="OMA" id="CTEPWRS"/>
    <dbReference type="OrthoDB" id="7608935at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051644">
        <property type="entry name" value="TRAMP_AT-DNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="309"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="355"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="392"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="162"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="500"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="556"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="573"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="584"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU45510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="595" mass="63829" checksum="02495FA4547E3170" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSG8</accession>
    <name>C7YSG8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glyoxylate reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_41786</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051348.1">
        <property type="nucleotide sequence ID" value="XM_003051302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSG8"/>
    <dbReference type="FunCoup" id="C7YSG8">
        <property type="interactions" value="500"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YSG8"/>
    <dbReference type="GeneID" id="9668195"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_41786"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_41786"/>
    <dbReference type="eggNOG" id="KOG0069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_2_1"/>
    <dbReference type="InParanoid" id="C7YSG8"/>
    <dbReference type="OMA" id="VMDAAPS"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000203">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase (SerA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF257">
        <property type="entry name" value="GLYOXYLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="64"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="121"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU45635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="35945" checksum="A2194339C23C42B1" modified="2009-10-13" version="1">MAPPKILLLGEIIHALESWRGLTSLAEIIGPGVENRNEFIEKCRQGGFDGVVVLHRMYHSVAVTGLIDEELVQALPESVKFICHTGAGYDQIDVAACSKRQIQVSNVPQEVNDSTADTAIFLMLGALRGFNQSIMTLRSGSWRGNPSPPLGHDPEGKTLGIIGCGGIGRNMAKKAAAFGMKVIYYNRTKSDDITEAEYVSLDDLLGSSDVIAISLPLNAATRHFLSYKDFEKMKQGVVVINTARGPIIDEQALVDALESGKVWSCGLDVYENEPAVHPGLVAHPRAMLLPHLGTYTVETHAKMEERCIANVRAALEKGKVNDLVPEQLGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7YUP5</accession>
    <name>C7YUP5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RTA1 like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_48509</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050158.1">
        <property type="nucleotide sequence ID" value="XM_003050112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YUP5"/>
    <dbReference type="GeneID" id="9674943"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_48509"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_48509"/>
    <dbReference type="eggNOG" id="ENOG502SHYP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033465_6_2_1"/>
    <dbReference type="InParanoid" id="C7YUP5"/>
    <dbReference type="OMA" id="NEVYFAC"/>
    <dbReference type="OrthoDB" id="4521223at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU44445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="32372" checksum="05D4DDEBB8A2D1D0" modified="2009-10-13" version="1" fragment="single">PIDGYVDPNFPNPNGDWDTPVIIYGYTPAFSLAVFAAVWFAVFLVVHLFQTIRFRSWYFITFPIGLLFEIVGYIARSLSAKDDPYHLLYFILNYFFIVTAPVFLAAGVYTILSALIPRLGRRYSFLPPKAILWFFITSDVIATVVQITGAALIGVRQSNRDDPTDANNILLGGLAYQVFSLGVFVILTASFLFRSRQEIRTRGRTLTSFCAAFAVATILIYLRTCFRLAETAEGLGGHLYSNEIYFACLEFAPVALAVLLFAIWYPGRCVGKKVGVKDLEKEQQSAVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7YV92</accession>
    <name>C7YV92_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_85193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050656.1">
        <property type="nucleotide sequence ID" value="XM_003050610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YV92"/>
    <dbReference type="GeneID" id="9675040"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85193"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85193"/>
    <dbReference type="eggNOG" id="ENOG502SZ6W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160184_0_0_1"/>
    <dbReference type="InParanoid" id="C7YV92"/>
    <dbReference type="OMA" id="CYHYTIS"/>
    <dbReference type="OrthoDB" id="5238343at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988700" evidence="1">
        <location>
            <begin position="19"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU44943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="101" mass="10578" checksum="C19C195FBF5CDF08" modified="2009-10-13" version="1">MKVALFASVIFLGRLGLALPPPQPVVVEPIDAASVVVEPIDPDSGCKPYQAPGCCVPSMCRCLDGKYYLFNKENKQGGGTGCDPPWGFLGDTVGAIPGYCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVF1</accession>
    <name>C7YVF1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_85253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050290.1">
        <property type="nucleotide sequence ID" value="XM_003050244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVF1"/>
    <dbReference type="STRING" id="660122.C7YVF1"/>
    <dbReference type="ESTHER" id="nech7-c7yvf1">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="9675075"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85253"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85253"/>
    <dbReference type="eggNOG" id="ENOG502RQNE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046066_1_3_1"/>
    <dbReference type="InParanoid" id="C7YVF1"/>
    <dbReference type="OMA" id="VRCQEGH"/>
    <dbReference type="OrthoDB" id="1263307at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF11">
        <property type="entry name" value="ESTERASE_LIPASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="9"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU44577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="252" mass="27471" checksum="EC7CB936CD4A1BB6" modified="2009-10-13" version="1">MSTPEKPTIVLVHGAWHLPSHYTMLKDKLTERGFTVIQPRNASVGQVSDIKGKTHLDDVAAIHEAMESPLNDRKEIIVVCHSYGGIPGSAAVEGYQIHERKNKGLKGGIKHVVYVASFALPARGLSLKTAIGGTYGPFMDRTDDYLPLNENAKNAFYHDLESELANRMLADCVYQSTASFETPSEFVAPDIAVPKTYVACENDRAIPIEGQLAMAGAMGDTVKIERLAAGHSPYLHPEFLSRLVEIIDGIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVT0</accession>
    <name>C7YVT0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ERCC4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">NECHADRAFT_29897</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EME1/MMS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU43846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049559.1">
        <property type="nucleotide sequence ID" value="XM_003049513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVT0"/>
    <dbReference type="STRING" id="660122.C7YVT0"/>
    <dbReference type="GeneID" id="9677339"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_29897"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_29897"/>
    <dbReference type="eggNOG" id="ENOG502R8ER">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013160_1_1_1"/>
    <dbReference type="InParanoid" id="C7YVT0"/>
    <dbReference type="OMA" id="EEIPRCT"/>
    <dbReference type="OrthoDB" id="343092at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20085">
        <property type="entry name" value="XPF_nuclease_Mms4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.670:FF:000004">
        <property type="entry name" value="Crossover junction endonuclease EME1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033310">
        <property type="entry name" value="Mms4/EME1/EME2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047521">
        <property type="entry name" value="XPF_nuclease_EME1_ascomycetes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077:SF5">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MMS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077">
        <property type="entry name" value="EME1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="15">
        <location>
            <begin position="81"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="22"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEU43846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="386" mass="43963" checksum="06F815C1364C58D4" modified="2009-10-13" version="1" fragment="single">DVIPSKSRSRSKPTTTTTSKKSAADRAREKEARAAAKEVDKETKRREKQEAKEAKAREKERNAALAEVNKLRTDKKVSTPEMMVDIPSSLNPTVTTQLTAMLEPLDVQFTTWESPVENVIKWRRKVKSRYNDDLGLWEPIPLRLQDEKHALVVMTADEFVKLALDDELSSHVEKMERHFSTHHILYLLEGLIPWMRKNRNLRNRQFTSRVRAQEASASNPSRRNKPAESYIPEETIEDALLQLQVMHDVMIHHTTIPLETAEWIVNFTQHVSTIPYRKQRDQATLVAGFCMESGQVKTGEDTKDTYVKMLQEIVRVTAPIAYGVAQEFTSISELVRGLEAGGPTRLEGVRKSANKDGTFSDRTIGQAVSRRMYKVFTGQDETSTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVW6</accession>
    <name>C7YVW6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pathway-specific nitrogen regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_74101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049785.1">
        <property type="nucleotide sequence ID" value="XM_003049739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVW6"/>
    <dbReference type="STRING" id="660122.C7YVW6"/>
    <dbReference type="GeneID" id="9677149"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74101"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74101"/>
    <dbReference type="eggNOG" id="ENOG502SAW3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_277723_0_0_1"/>
    <dbReference type="InParanoid" id="C7YVW6"/>
    <dbReference type="OMA" id="QIDNHEK"/>
    <dbReference type="OrthoDB" id="5369448at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="926"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="750"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="768"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="939"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="973"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1070"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1117"/>
            <end position="1146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU44072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1146" mass="128803" checksum="69F1430DF44D08C7" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWR7</accession>
    <name>C7YWR7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_70699</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049421.1">
        <property type="nucleotide sequence ID" value="XM_003049375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWR7"/>
    <dbReference type="GeneID" id="9677057"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_70699"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_70699"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012970_1_0_1"/>
    <dbReference type="InParanoid" id="C7YWR7"/>
    <dbReference type="OMA" id="DISWRWG"/>
    <dbReference type="OrthoDB" id="4078873at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000302">
        <property type="entry name" value="MFS siderochrome iron transporter MirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000284">
        <property type="entry name" value="Siderophore iron transporter mirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
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    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF50">
        <property type="entry name" value="MFS SIDEROCHROME IRON TRANSPORTER MIRB (AFU_ORTHOLOGUE AFUA_3G03640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0410">Iron transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="447"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="484"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="562"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="13">
        <location>
            <begin position="80"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU43708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="596" mass="65173" checksum="F11547111FF6CA1D" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7YX14</accession>
    <name>C7YX14_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enoyl-CoA hydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_82857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049464.1">
        <property type="nucleotide sequence ID" value="XM_003049418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YX14"/>
    <dbReference type="STRING" id="660122.C7YX14"/>
    <dbReference type="GeneID" id="9666126"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82857"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82857"/>
    <dbReference type="eggNOG" id="KOG1681">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_946666_0_0_1"/>
    <dbReference type="InParanoid" id="C7YX14"/>
    <dbReference type="OMA" id="FCTTPMV"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051683">
        <property type="entry name" value="Enoyl-CoA_Hydratase/Isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42964">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42964:SF1">
        <property type="entry name" value="POLYKETIDE BIOSYNTHESIS ENOYL-COA HYDRATASE PKSH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU43751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="30600" checksum="718B1E1F893F81A1" modified="2009-10-13" version="1">MASQILEQRDGSTLFITINNPKKGNSLNVDLIVKLRQVIEDAGKDNTLIAIVLTGAGKYFCTGMDLSSSSSLLENVPKGADRSNTQAGRFEQLLDLFKAVEFCPKPIIALINGPCYGGGTGLAFACDIRISVSSAFFVLSEVRRGLTPAIISPFIVREWGAPLAREAMIQARNVPASELHAKGSVHYLVDTLAEGQERVQQVLKQQRGCAPHAVGESKRMIRNALDSPTVEERDAKIRELFLTMIKPNEEVAYGMKEFQTGNRNVDWAAWYTKKASSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7YX74</accession>
    <name>C7YX74_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_82917</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049495.1">
        <property type="nucleotide sequence ID" value="XM_003049449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YX74"/>
    <dbReference type="GeneID" id="9676926"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82917"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82917"/>
    <dbReference type="HOGENOM" id="CLU_801906_0_0_1"/>
    <dbReference type="InParanoid" id="C7YX74"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="3">
        <location>
            <begin position="137"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU43782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="346" mass="39563" checksum="4D6DF859389C3B10" modified="2009-10-13" version="1">MTDGLRLQGDSLPIEYPTYDWGKSPSTDYHDHDWFWPLNKRVLTVSLLNGTNEEKNIIINLINEHYNTIKMGIRFKFLQDGDSTLSDIRVAVTTSSESTDGYMATTVPRNVPTLRLQMSLSRPGGPLQKDIDRRQSKILHEFGHALGLKHAHCHPDCTINWNHQVIEKRMGWTHDEFETQVRIAKEGIFALMPYDPKSIMHYSVRKGDTHSMITCLEPNLVLSKGDKKFLMAIYPPDGSDRTLKGVTERMWKPTSVLLREGKKRRDLRSAARQDLGHSNEGETFPSITLTDSEIQDLGSFFTDSQNGHLGTAFLQTIFPQAYRLEIFSIAFFYCAFMGYVGFLLFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXA3</accession>
    <name>C7YXA3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_82946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049504.1">
        <property type="nucleotide sequence ID" value="XM_003049458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXA3"/>
    <dbReference type="GeneID" id="9666250"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82946"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82946"/>
    <dbReference type="eggNOG" id="ENOG502RR8R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168414_1_0_1"/>
    <dbReference type="InParanoid" id="C7YXA3"/>
    <dbReference type="OMA" id="CCETNAV"/>
    <dbReference type="OrthoDB" id="8115477at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988759" description="Hydrophobin" evidence="2">
        <location>
            <begin position="18"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU43791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="11359" checksum="ED1EF03D1FACFC84" modified="2009-10-13" version="1">MQFTLASILAIAAVVTAAPAPGLPILGGGEDDGRESAPQPQGGDTTTTTTTNTNSNNKVCSVENQQVCCTGLLACAVQLLGEECKGGNAYCCNTGAEKGTLINIALANCVDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXC7</accession>
    <name>C7YXC7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">ABC transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">NECHADRAFT_45338</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049280.1">
        <property type="nucleotide sequence ID" value="XM_003049234.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9666261"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45338"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45338"/>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_27_1_1"/>
    <dbReference type="InParanoid" id="C7YXC7"/>
    <dbReference type="OMA" id="CMQTFEY"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002145">
        <property type="entry name" value="ABC transporter (MsbA subfamily)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF464">
        <property type="entry name" value="ABC-TYPE TRANSPORTER CICA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="760"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="802"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="839"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="903"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="992"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1016"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="146"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="472"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="762"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="1084"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="714"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEU43567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1332" mass="146264" checksum="8828B590220C779D" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXG1</accession>
    <name>C7YXG1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HypA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_45357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049297.1">
        <property type="nucleotide sequence ID" value="XM_003049251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXG1"/>
    <dbReference type="GeneID" id="9677104"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45357"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45357"/>
    <dbReference type="eggNOG" id="ENOG502S69W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019145_2_1_1"/>
    <dbReference type="InParanoid" id="C7YXG1"/>
    <dbReference type="OMA" id="WLKIARM"/>
    <dbReference type="OrthoDB" id="10004862at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF7">
        <property type="entry name" value="BAEYER-VILLIGER OXIDASE MDPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU43584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="50444" checksum="5DB1BD2B5DF4B55A" modified="2009-10-13" version="1">MAGASTVEISQDNVGVFHVLLVPDETIKTANELLQANHEQHHVFFNDRGFHNHITHYILTQAALGATPTQMRRAYTQERSLQRPQHPLDEEIVSRLENENYFLACLSRPDNYHNFLRFFECQIAQRGIGAVVHEYLFSRSRIAEELLSRLFASFLHPVIHFGFGLEFNQPAIIAEGLAQSAVRQPEVGKFFKGIQTAEESLKNNPSRPMIDLIREIEQNDAIRSAACWGDGSWIDDNPLANAPEELWKIAAQWRVSPQELKLKTAEMINVCTFYTAAAQRPEKQHKLDFFLIHNVNCSIFFSSLVEKDWISLEDKARLLEWKGRFDIVAYAARGSPQLRINEVVNYRPKKPEMGWEQLFKRVNAFLDDSHVTKLVRALANGERASLEYEERVDFPMKQSMFLKTAHIALDSTEEALYPDRWVKGAGFEQQWAKFRDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXJ5</accession>
    <name>C7YXJ5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="9">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_44993</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="9"/>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049065.1">
        <property type="nucleotide sequence ID" value="XM_003049019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXJ5"/>
    <dbReference type="STRING" id="660122.C7YXJ5"/>
    <dbReference type="GeneID" id="9666369"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_44993"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_44993"/>
    <dbReference type="eggNOG" id="KOG0975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031922_0_0_1"/>
    <dbReference type="InParanoid" id="C7YXJ5"/>
    <dbReference type="OMA" id="HMVTCRW"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000012">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF69">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU43352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="391" mass="43697" checksum="9D4BA857FC360930" modified="2009-10-13" version="1">MSLGSSQLNGASAPKQRLDASKLKFTQSTVLHPVPEPGSPELWAQNVHTDHMMTCRWTAEKGWDVPELKPFADFSISPLASCIHYATQCFEGMKVYRGFDNRVRLFRPDRNAKRLVMSAKRVSLPEFDDAELVELIKALVRTDAKRWLAEPGSFRYVRPALIGTGRQLGVQIPREAVLFVVMVCWPDFSTDSPPGVTPRSDLRLLTSRNDTIRAWPGGFGYAKVGANYGPSFASHCEAQESGYDQILWLFGDDGQVTEAGASNFFAVVKDERTSKLQLLTAPLDDKLILDGVTRRSVLELVESRLTDELMVKEAKFTMSDLEKAWKEGRLLEAFVSGTAFFIKDVSTIRVGNRNLDLTQNNDGTGKFGPRIKGWLKDIMFGVEENKWGVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXK0</accession>
    <name>C7YXK0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_45389</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049069.1">
        <property type="nucleotide sequence ID" value="XM_003049023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXK0"/>
    <dbReference type="GeneID" id="9666370"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45389"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45389"/>
    <dbReference type="eggNOG" id="ENOG502S1YX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_5_2_1"/>
    <dbReference type="InParanoid" id="C7YXK0"/>
    <dbReference type="OMA" id="YLAFADH"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030798">
        <property type="term" value="F:trans-aconitate 2-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.290">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023149">
        <property type="entry name" value="Trans_acon_MeTrfase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002463">
        <property type="entry name" value="PRK01683.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="3">
        <location>
            <begin position="59"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU43356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="283" mass="31889" checksum="522097768E03C284" modified="2009-10-13" version="1">MTSIVSRSNFHISTRSMMAQTEPKAQDWSASQYLKFAKQRTRPSRDLLAQVPLESPSFILDVGCGPGNSTQVLVDRYPGAVIEGIDSSPGMITEARKALPQIKFSVADLKTHTPQKPLDLVFSNAVFQWLKADERVPTMKRMMQWLRPGGVLAIQVPDNYLEPSHIAMRAVANEGRWASILGPLRPALDQFATPQQFYDELSPLSSSVDIWHTLYQHPLDDHQSLVEWVKGTGLRPFLNPLSPEDKEAFAESYLARLKDIYPVSVDGKVLLRYPRLFMIAVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYU0</accession>
    <name>C7YYU0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_9915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048967.1">
        <property type="nucleotide sequence ID" value="XM_003048921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYU0"/>
    <dbReference type="GeneID" id="9665617"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_9915"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_9915"/>
    <dbReference type="eggNOG" id="ENOG502S7FQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2378383_0_0_1"/>
    <dbReference type="InParanoid" id="C7YYU0"/>
    <dbReference type="OMA" id="PQKETEW"/>
    <dbReference type="OrthoDB" id="2253354at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035213">
        <property type="entry name" value="DUF5321"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17254">
        <property type="entry name" value="DUF5321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU43254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="78" mass="9045" checksum="7561EC68958B4BD6" modified="2009-10-13" version="1" fragment="single">KTREWNPATFFIAIFLLIGSMSIQMIALRNSFDRYMRQSEARIMALRDVVEKIQRGEPVDVEKALGTGDPKKEADWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZ86</accession>
    <name>C7YZ86_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA wybutosine-synthesizing protein 4</fullName>
            <ecNumber evidence="5">2.1.1.290</ecNumber>
            <ecNumber evidence="4">2.3.1.231</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Leucine carboxyl methyltransferase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">NECHADRAFT_47919</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine + CO2 = wybutosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:37119"/>
            <dbReference type="Rhea" id="RHEA-COMP:11844"/>
            <dbReference type="Rhea" id="RHEA-COMP:11847"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73544"/>
            <dbReference type="ChEBI" id="CHEBI:74275"/>
            <dbReference type="EC" id="2.3.1.231"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36903"/>
            <dbReference type="Rhea" id="RHEA-COMP:10379"/>
            <dbReference type="Rhea" id="RHEA-COMP:11844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73543"/>
            <dbReference type="ChEBI" id="CHEBI:74275"/>
            <dbReference type="EC" id="2.1.1.290"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.290" evidence="5"/>
    <dbReference type="EC" id="2.3.1.231" evidence="4"/>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048272.1">
        <property type="nucleotide sequence ID" value="XM_003048226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZ86"/>
    <dbReference type="FunCoup" id="C7YZ86">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YZ86"/>
    <dbReference type="GeneID" id="9667551"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_47919"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_47919"/>
    <dbReference type="eggNOG" id="KOG2132">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2918">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002761_1_0_1"/>
    <dbReference type="InParanoid" id="C7YZ86"/>
    <dbReference type="OMA" id="FCILEQF"/>
    <dbReference type="OrthoDB" id="47172at2759"/>
    <dbReference type="UniPathway" id="UPA00375"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000043">
        <property type="entry name" value="tRNA wybutosine-synthesizing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46529">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46529:SF1">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13418">
        <property type="entry name" value="Beta-prop_TYW4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="JmjC" evidence="16">
        <location>
            <begin position="802"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEU42559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="992" mass="109815" checksum="CA82F590F4D5FAB4" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z046</accession>
    <name>C7Z046_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_95873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048621.1">
        <property type="nucleotide sequence ID" value="XM_003048575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z046"/>
    <dbReference type="STRING" id="660122.C7Z046"/>
    <dbReference type="GeneID" id="9667512"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95873"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95873"/>
    <dbReference type="eggNOG" id="ENOG502S2W2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038717_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z046"/>
    <dbReference type="OMA" id="HNFLIYD"/>
    <dbReference type="OrthoDB" id="72269at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="389" mass="43456" checksum="86698DA8383FAE00" modified="2009-10-13" version="1">MPSSSSSGLSGRIIPILTLSALSIFAFDALLIQLDRNGYSALLNEILDDPNPRFLPGSERLLLRRYTGVPWLDRGFALSNLIWANVVDGSRPELSLFAFCFGAQLLPFFLVFMIESQRVVGWSRLVFNPIIWGMLMQAFGFGFIMPLFTVVHLLWTSNVTRSQTVYLRDHTSLHTVVPAFLLGYVLLCGLLAFPFPDDNLRQWLNIIWTWFPLHVVVLQTLFTGLLKRMSIGQDTFTPKVKLDREALSYAYGFAWNVAVIGQMSTYAVLIAANIFPGVFPHGVARRLTLERVFIPDAPHTYTPMKDTGSAMHNFFNYDLYIGSISGLIWAVHLLLQVRPELSSGEERTNLARGVATSFLLSGPGGALVALMQHRDDVVLIAEAKADKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z112</accession>
    <name>C7Z112_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">glutaryl-CoA dehydrogenase (ETF)</fullName>
            <ecNumber evidence="11">1.3.8.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">NECHADRAFT_60828</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>glutaryl-CoA + oxidized [electron-transfer flavoprotein] + 2 H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13389"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid metabolism; lysine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid metabolism; tryptophan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.6" evidence="11"/>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048198.1">
        <property type="nucleotide sequence ID" value="XM_003048152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z112"/>
    <dbReference type="STRING" id="660122.C7Z112"/>
    <dbReference type="GeneID" id="9667370"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_60828"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_60828"/>
    <dbReference type="eggNOG" id="KOG0138">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_8_0_1"/>
    <dbReference type="InParanoid" id="C7Z112"/>
    <dbReference type="OMA" id="HMMNLES"/>
    <dbReference type="OrthoDB" id="435240at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004361">
        <property type="term" value="F:glutaryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01151">
        <property type="entry name" value="GCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000003">
        <property type="entry name" value="glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000006">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000008">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052033">
        <property type="entry name" value="Glutaryl-CoA_DH_mitochondrial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807:SF1">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="16">
        <location>
            <begin position="47"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="15">
        <location>
            <begin position="162"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="14">
        <location>
            <begin position="277"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEU42485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="427" mass="46531" checksum="32F70CD9B9CB1C9D" modified="2009-10-13" version="1">MFRPILRQCARRASAAPLRPLAARSFASATGPSFNWEDPLNSNNLLTEEERAIGETAERYCQEHLLPRVLQAYRDENYDAKMLEEMGELGLLGATIDGYGCAGVSSVAGGLITRAVERVDSGYRSGMSVQSSLVMGGIYEHGTAEQKERFLPEMAKGKLLGAFGLTEPNHGSDPGSMETVARPHPTKKGYYLLSGAKTWITNSPIADVLMVWAKLQETGKIRGFLVERKDCPAGTLETPAIKDKNGLRASITGMIQLDDCPVPEENMFPNVEGLKGPFSCLNNARYGIALGVMGALEDCIDRARTYSLERKQFKGNPLAKYQLIQKKLADASTDAAYGTLAAIQVGRLKDEGKATPEMISMVKRQNCDAALRNARILQEIFGGNAVSDEYMIGRHVANLFVTQTYEGQSDIHSLILGRAITGVQAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z189</accession>
    <name>C7Z189_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_80152</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048033.1">
        <property type="nucleotide sequence ID" value="XM_003047987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z189"/>
    <dbReference type="GeneID" id="9672018"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_80152"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_80152"/>
    <dbReference type="eggNOG" id="ENOG502T3BB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_943622_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z189"/>
    <dbReference type="OrthoDB" id="4757095at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="2">
        <location>
            <begin position="19"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU42320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="295" mass="34518" checksum="5195C60900812021" modified="2009-10-13" version="1">MLMNFETRDQIDKPGPVNGQEQSPFFQKLIPDVRRLIYLEVFGSRSVHVVPGPGIGSPKYVLYTCRQPDDAPPHSECPDVGEEKCRLSTNLLYTCQMAYNEGATLLFKSNKFLFSDQTDCTFFFHLVPDSFQNSVRSLNVCVKFHIYDTHLIHTMCEELSNWTGDFKLRMRWDMDHPRRKKRYANFNTALDAIQQLMKNPRVRPKFWAPKMLEDGMGLILKKEDRLRLEFVKDESEPDPNDDDDGEEDDDEDEDEYDWDDDSEDYDEYDSEGCMTDVDHDDEETLRYWEALAGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1W0</accession>
    <name>C7Z1W0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_50902</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU41894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047607.1">
        <property type="nucleotide sequence ID" value="XM_003047561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1W0"/>
    <dbReference type="STRING" id="660122.C7Z1W0"/>
    <dbReference type="GeneID" id="9671566"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_50902"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_50902"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_14_0_1"/>
    <dbReference type="InParanoid" id="C7Z1W0"/>
    <dbReference type="OMA" id="GHSGAEY"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd10291">
        <property type="entry name" value="GST_C_YfcG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000172">
        <property type="entry name" value="Glutathione S-transferase GstA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="98"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU41894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="28969" checksum="4207BCB4791514BE" modified="2009-10-13" version="1">MASKTKTDITLYTVGTPNGIKASILLEELGLDYKVYPIKMSENEQKEPWFLEINPNGRIPAMTDTLNGEKIRVFESGAILQYLVDRYDKDHKVSYPYGSREHWETTSWLMWQMGGLGPMQGQANHFKRYAPEKIEYGINRYVNETRRLYRTLDTHLEKSSSGYIVGDKVTIADISCWGWVSSAKWAGVDLSEFPHLEKWLYKLLERPGFEAGRHVPTPHTAFETNKLTEEEIEAKAAASKAWIQAGMKDDAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z2A1</accession>
    <name>C7Z2A1_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_50679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU42136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047849.1">
        <property type="nucleotide sequence ID" value="XM_003047803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z2A1"/>
    <dbReference type="GeneID" id="9671815"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_50679"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_50679"/>
    <dbReference type="eggNOG" id="ENOG502SBBK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125059_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z2A1"/>
    <dbReference type="OMA" id="ERPIMAP"/>
    <dbReference type="OrthoDB" id="5399555at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="121" mass="13296" checksum="D1F0DF87F9E7ED8A" modified="2009-10-13" version="1">MPASLDSSRPIMAPSVSDPSKNRNSVRFSTYSMAPSFAPTVQTTDSAHAEIRDIATGLDRMENKALTSQRVVLTDEKTDTMSKLALGAKLERALDRRMVGQDAVMRPRGQSLNEKLSEKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z2K0</accession>
    <name>C7Z2K0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein S-acyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_54272</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.225" evidence="1"/>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047390.1">
        <property type="nucleotide sequence ID" value="XM_003047344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z2K0"/>
    <dbReference type="STRING" id="660122.C7Z2K0"/>
    <dbReference type="GeneID" id="9676046"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_54272"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_54272"/>
    <dbReference type="HOGENOM" id="CLU_000134_45_2_1"/>
    <dbReference type="InParanoid" id="C7Z2K0"/>
    <dbReference type="OMA" id="KWLHGQG"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="25"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="58"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU41677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="91" mass="9955" checksum="BAE39ACABF3A9EEB" modified="2009-10-13" version="1">MCGAADVIPRLLSTPDIEIDSRDEEGLTPLMFAVSHGHEEVSRLLLNANADPFLKDEEGRAALYHAASKGHVATMRILLKTNPDLIRFNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z2R9</accession>
    <name>C7Z2R9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="2">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_97788</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="2"/>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047239.1">
        <property type="nucleotide sequence ID" value="XM_003047193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z2R9"/>
    <dbReference type="FunCoup" id="C7Z2R9">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z2R9"/>
    <dbReference type="GeneID" id="9676080"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_97788"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_97788"/>
    <dbReference type="eggNOG" id="ENOG502QPT5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031468_10_3_1"/>
    <dbReference type="InParanoid" id="C7Z2R9"/>
    <dbReference type="OMA" id="GMIDEVN"/>
    <dbReference type="OrthoDB" id="73846at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050838">
        <property type="entry name" value="Ketopantoate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765:SF2">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="6">
        <location>
            <begin position="10"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="7">
        <location>
            <begin position="221"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU41526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="360" mass="39772" checksum="4D53FAF0D9706E11" modified="2009-10-13" version="1">MTVKARQHRVHVLGLGSIGTFAAHSLAEVPCPLTPSVTLLLHRASLVDNFVASGSKITLETREGVVIDHGKYDLEVLQDGQWYQHQSTQLDPSPTDDVIDNLVVSTKATQTASALRPLKHRLNGSSYILFLQNGSGMIEDVNKHVFTDEQTRPNYITGVTSHGVTLNSPFNIVHTGFAATSLGLVPRSDKIVQNTAATSYLLEALPLVPRLNATSYTFLDVFQIQLEKLTVNAFCNPLCALNDAKNGFLFTIPETRRAILTEISQVVYALPELHGVPGVLERFSVDRLAATVNGIIQKTAETTCSMVVDLRRGQKTEIEFINGYWCRRGREVGVPTPINDDLVRQILRRQGDEELVKNYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z3E8</accession>
    <name>C7Z3E8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_88890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698908">
        <property type="protein sequence ID" value="EEU41460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047173.1">
        <property type="nucleotide sequence ID" value="XM_003047127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z3E8"/>
    <dbReference type="GeneID" id="9675787"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88890"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88890"/>
    <dbReference type="HOGENOM" id="CLU_1005065_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z3E8"/>
    <dbReference type="OMA" id="TMENNYV"/>
    <dbReference type="OrthoDB" id="5100601at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988902" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU41460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="28337" checksum="8D0449DA253A34EA" modified="2009-10-13" version="1">MRSFPCLVAAALLLGSTSASAGPCQPQSWTTLISTTDTVAISSSTTALSSTSVTESVSETSATSTKAISSSISETSTASTTIVTSSTETSAIPGTTTSDFTTITTTTSQAPIPTVSQTFEVKAAQSDNTAVNGAVLHVTNNPSYALYLISPPRTSGSVLPGAFSIEEGTSRLMVGEWYVYTNAPDPYSMYAGPASSVGPNQAYISCTKPELVGEALQCSSATAGPIYFSVSSTATGSTNIMPWKVGSVHAGYSAVNLVAASKQVTSETSRVVQCCYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z3K1</accession>
    <name>C7Z3K1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycoside hydrolase family 105</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_46339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046862.1">
        <property type="nucleotide sequence ID" value="XM_003046816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z3K1"/>
    <dbReference type="GeneID" id="9675767"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_46339"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_46339"/>
    <dbReference type="eggNOG" id="ENOG502SMGG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038720_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z3K1"/>
    <dbReference type="OMA" id="YARWTHE"/>
    <dbReference type="OrthoDB" id="540611at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052043">
        <property type="entry name" value="PolySaccharide_Degr_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886:SF9">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988461" description="Glycoside hydrolase family 105" evidence="2">
        <location>
            <begin position="18"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU41149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="46064" checksum="47187191E2E330C6" modified="2009-10-13" version="1">MKGSFFVLQFIASAALAAVQLPRGWFTIQPTEKIKASKFQGKPRYLTWMADSQIQHGVEPTLAYTVSAFYSGVLLAYERTGDKKYFDYVKHGADILLYPEHDGTVLFYNNSNSIDDIRIGHTFLDMFNATGDDIYKKAATHMRNQIDRTGRTPEGGFYHRYPGYIDQMWLDGIYMLDVFYARWTYEFEPDNTTAWDDIALQFDIINKVTTSSNHTNGLPVHGFDAGKTQVWADPVTGAAPHVWGRAVGWYIMALVDTLDYFPESHNGRKRLISYLNSLIDAIVAAQDPKTKGWWLIMDPELAGVHGNYIESSGSAMCVNGLLKALRMGYISGTKYTKAALDGYELMTTSFAQPRGHGALAWEWTVQTGSLSSNGTFEYYASMPLFQNDLKGVAPFLFASYEYELFSSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4X5</accession>
    <name>C7Z4X5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cat eye syndrome critical region protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_91209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046135.1">
        <property type="nucleotide sequence ID" value="XM_003046089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4X5"/>
    <dbReference type="STRING" id="660122.C7Z4X5"/>
    <dbReference type="GeneID" id="9678241"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_91209"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_91209"/>
    <dbReference type="eggNOG" id="KOG1618">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030880_1_1_1"/>
    <dbReference type="InParanoid" id="C7Z4X5"/>
    <dbReference type="OMA" id="HDKRMLV"/>
    <dbReference type="OrthoDB" id="270009at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF57">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU40422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="53132" checksum="868EB545820C9D89" modified="2009-10-13" version="1">MQRFGAVGQCRLAARRCATPMTAAPDGSLVNPNDFQEPSEASRKLFSEIAFAFDIDGVLYQGRNRVEGAEKVIKMIRSNGIRYVFLTNGGGVPEVKKADTLQERLQIAKNDDVIRGRMILSHTPMSAWSDELKNHGTILITGSHPEQARQIALDYGFKRVVTPADILAECKDVFPFDHLEGDVNGKPVPLPDGKRIPLLKDPYTTNIPHNALKIDQIFVWNDPRDWSVDIQIIHDLLISHEGYLGTISHRNGDKSLPNNGWQQDNQPGLWISNMDLLWKTNYPVNRFGTGAFMEALKGVWSMTTDGKELEYNALGKPSNYTYKYAHDRLLQYYHDMACNRGKSPSHDITKCHPLRRVYMIGDNPESDIRGANDFNAEDGTEWVPILVRTGVWRQTLTEKEPRHKPAVIVDDVVDAVVWALNNEGMKATREWLLSAVSHTKGYVKVPELEQEGNLKETGVKYPSEEEAGEAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z521</accession>
    <name>C7Z521_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_76719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046157.1">
        <property type="nucleotide sequence ID" value="XM_003046111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z521"/>
    <dbReference type="GeneID" id="9678263"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76719"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76719"/>
    <dbReference type="eggNOG" id="ENOG502RD9U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039755_2_1_1"/>
    <dbReference type="InParanoid" id="C7Z521"/>
    <dbReference type="OMA" id="NDCLERD"/>
    <dbReference type="OrthoDB" id="5416097at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="2">
        <location>
            <begin position="178"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU40444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="521" mass="58094" checksum="36F8FF12E8A08407" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z575</accession>
    <name>C7Z575_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_76770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046185.1">
        <property type="nucleotide sequence ID" value="XM_003046139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z575"/>
    <dbReference type="GeneID" id="9678569"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76770"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76770"/>
    <dbReference type="eggNOG" id="ENOG502RJAW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1256340_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z575"/>
    <dbReference type="OrthoDB" id="5078657at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU40472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="220" mass="26117" checksum="8CB6B7C3C2E98CBA" modified="2009-10-13" version="1">MTFDDIVSPRTLFNSILNDEIVKAAYKQCKSQPVKCANEILPRHPLWYTRRTGIQNLFAGLRLPNVQTKDDGYVKHYTSSTRERNGSRYTLEWAEQRGNHIMVVSRLETRLPHREAPKRKAVNADYGMRHEISQRMKEVQRGILRGKHLNRVFYVVGIKDTPEETIWYLARRVLQSMRTFKSPLTLTEKAREQWKVEQEKYAEKQQYKWKHLTPESSKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z581</accession>
    <name>C7Z581_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ornithine cyclodeaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_34345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ornithine cyclodeaminase/mu-crystallin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU41053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046766.1">
        <property type="nucleotide sequence ID" value="XM_003046720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z581"/>
    <dbReference type="FunCoup" id="C7Z581">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z581"/>
    <dbReference type="GeneID" id="9678295"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_34345"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_34345"/>
    <dbReference type="eggNOG" id="KOG3007">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042088_0_1_1"/>
    <dbReference type="InParanoid" id="C7Z581"/>
    <dbReference type="OMA" id="IYCCTPS"/>
    <dbReference type="OrthoDB" id="41492at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000577">
        <property type="entry name" value="Proline utilization protein PrnX, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="entry name" value="ornithine cyclodeaminase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812:SF19">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU41053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="455" mass="50164" checksum="0A97AAB010842B8C" modified="2009-10-13" version="1">MTYTILSDDQVNSILEGLTVDELEEFRHVLASSLHEFSTGVPALEAAYQQPNRISTTHPETQARTLYMPSCAPCGMGCKVISLTTAEASQEADSKPITPTGVVNLFRPDGSPLGIVHASALTAFRTALASTCLLARRGHVKTLTVFGSGLQAYWHIRLALMMRGHTIKHVHIINRRWSENATSLLKKFASIPPEIKEREGWTDVKFGLLIPAFHEYNRLLKEQMRDADVIYCCTSSQEDLFDASILTSHEGRKKGRLIIAVGSYTPEMRELPDDLLQLAVKQYDKPHRHYHKHAPEGGVIVVDNIKGVLKEAGEIIAAKIGPNQLVELGELVMLHRQALEESDDPISSQTSLASDDRFDHGRSSISTVFGSDAPSSPSSVSSDPRKSGSIFHFRKGSNSSLDKEKGKNEDHLVRWLRDGTVIYKSVGLGLMDLVVGMHLVEVANEKHIGTVIKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z5D5</accession>
    <name>C7Z5D5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_28207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU41080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046793.1">
        <property type="nucleotide sequence ID" value="XM_003046747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z5D5"/>
    <dbReference type="GeneID" id="9678598"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_28207"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_28207"/>
    <dbReference type="eggNOG" id="ENOG502QQ71">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027506_3_0_1"/>
    <dbReference type="InParanoid" id="C7Z5D5"/>
    <dbReference type="OMA" id="PTIRTGK"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF68">
        <property type="entry name" value="GLYCOSIDASE CRH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988502" description="GH16 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="23"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU41080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="275" mass="29624" checksum="D7906ED636EA34DA" modified="2009-10-13" version="1" fragment="single">MFSKALSTAAVVLAAAGLVSAQTYTDCNPLKKTCPANPAFGDNKVDCDWTKGECDAFHSMIGTSLKYDGKGASFIINKESDAPTIRTDNYIFFGRVDVVVQAAQGQGIVTSAVLQSDDLDEIDWEWVGGDNAQVQSNYFSKGDTTTYDRAVYHPVSAPLTSTHKYSVEWTSTKIDWLIDDAVVRTLNAADAKGGSAFPQTPMQIKMGTWVAGGKNSNAGTREWAGGYTNFDDAPFTAYYKSITIVDYAGKDAPGQNAGAKEYVYGDNSGDWTSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z5L8</accession>
    <name>C7Z5L8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_32272</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046258.1">
        <property type="nucleotide sequence ID" value="XM_003046212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z5L8"/>
    <dbReference type="STRING" id="660122.C7Z5L8"/>
    <dbReference type="GeneID" id="9678639"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_32272"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_32272"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017099_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z5L8"/>
    <dbReference type="OMA" id="GRIWEAE"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="65"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="476"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="565"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="601"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="663"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="680"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="734"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU40545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="757" mass="85665" checksum="7A3ECAB14DDDDBA6" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z664</accession>
    <name>C7Z664_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_8936</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045785.1">
        <property type="nucleotide sequence ID" value="XM_003045739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z664"/>
    <dbReference type="STRING" id="660122.C7Z664"/>
    <dbReference type="GeneID" id="9667917"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_8936"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_8936"/>
    <dbReference type="HOGENOM" id="CLU_000134_45_3_1"/>
    <dbReference type="InParanoid" id="C7Z664"/>
    <dbReference type="OMA" id="SRDIENQ"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU40072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="90" mass="9526" checksum="6FCF52F3943BEDEB" modified="2009-10-13" version="1" fragment="single">GQTPLHHAAEAWKGEEVASLLLAKGNPDLEVQDMGGRTPLHCASQLGSEALVSLLLDEGVANANCRDLEGRTPLSLAAQRGQLQIVDKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z697</accession>
    <name>C7Z697_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_76026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046374.1">
        <property type="nucleotide sequence ID" value="XM_003046328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z697"/>
    <dbReference type="STRING" id="660122.C7Z697"/>
    <dbReference type="GeneID" id="9667934"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76026"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76026"/>
    <dbReference type="eggNOG" id="ENOG502SNFY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002639_5_5_1"/>
    <dbReference type="InParanoid" id="C7Z697"/>
    <dbReference type="OMA" id="NDANCNE"/>
    <dbReference type="OrthoDB" id="5347061at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="194"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU40661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="659" mass="75327" checksum="A13941250F7D6D81" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6E9</accession>
    <name>C7Z6E9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mg2+ transporter protein, CorA-like/Zinc transport protein ZntB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_76078</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046394.1">
        <property type="nucleotide sequence ID" value="XM_003046348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6E9"/>
    <dbReference type="GeneID" id="9667954"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76078"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76078"/>
    <dbReference type="eggNOG" id="ENOG502S52U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013571_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z6E9"/>
    <dbReference type="OMA" id="DPRWLNV"/>
    <dbReference type="OrthoDB" id="3231000at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="725"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="783"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="808"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="836"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="451"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU40681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="911" mass="105511" checksum="EE685F56D907CB8B" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6K5</accession>
    <name>C7Z6K5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_66139</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.2.9" evidence="1"/>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045860.1">
        <property type="nucleotide sequence ID" value="XM_003045814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6K5"/>
    <dbReference type="GeneID" id="9668058"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_66139"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_66139"/>
    <dbReference type="eggNOG" id="ENOG502S329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030506_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z6K5"/>
    <dbReference type="OMA" id="CFAGTQY"/>
    <dbReference type="OrthoDB" id="2017317at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935:SF0">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="81"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU40147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="397" mass="44697" checksum="967A9649BD7EF8A2" modified="2009-10-13" version="1">MSQHEEQPGVASAVSDAGTKTCALASLCKLSVAQRPAPEPTLVPKYPAVSSIPRTSAERLALAAEDVVDDPDHSKPNTYLYLAYGSNLCAQTFLGMRGIRPLSQVNVSVPTLELKFDLPGIPYREPCFANVGYRKLPDKPKLPPKIPFDPPRPPHSESQWDEGLLGVVYEVTEEDYKTIIRTEGGGTGYKQIMVPCLPLPPKMSIPEKPFPEIPKPFLAKTLFAPQIPDSDLPDDPRKKKWWYRFLIHPVREPGYAQPSARYLNLIRDGAKEHELPEGYQRWLNGMPTYTITNWRQHIGAAVYLVISLVFFAIMALSGPLADKDGKLPRWLALATTVFFNLSWMMYDGILKPVLGDGERTEETEQRWGHKKKSSWSQVRQRIPHLDEEKVGLLKEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7P2</accession>
    <name>C7Z7P2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 55</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_106067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045436.1">
        <property type="nucleotide sequence ID" value="XM_003045390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7P2"/>
    <dbReference type="STRING" id="660122.C7Z7P2"/>
    <dbReference type="GeneID" id="9672620"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_106067"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_106067"/>
    <dbReference type="eggNOG" id="ENOG502QV54">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002540_2_1_1"/>
    <dbReference type="InParanoid" id="C7Z7P2"/>
    <dbReference type="OMA" id="AVFMNWN"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000023">
        <property type="entry name" value="Exo-beta-1,3-glucanase Exg0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002987922" evidence="1">
        <location>
            <begin position="27"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="78"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="428"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU39723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="798" mass="85905" checksum="92ABC847A00F8E57" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z808</accession>
    <name>C7Z808_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dihydroxy-acid dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_39348</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045631.1">
        <property type="nucleotide sequence ID" value="XM_003045585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z808"/>
    <dbReference type="STRING" id="660122.C7Z808"/>
    <dbReference type="GeneID" id="9672398"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_39348"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_39348"/>
    <dbReference type="eggNOG" id="KOG2448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014271_3_0_1"/>
    <dbReference type="InParanoid" id="C7Z808"/>
    <dbReference type="OMA" id="MMFRNLA"/>
    <dbReference type="OrthoDB" id="3851628at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052352">
        <property type="entry name" value="Sugar_Degrad_Dehydratases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004784">
        <property type="entry name" value="PRK06131.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43183:SF1">
        <property type="entry name" value="HYPOTHETICAL DIHYDROXY-ACID DEHYDRATASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43183">
        <property type="entry name" value="HYPOTHETICAL DIHYDROXYACID DEHYDRATASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="6">
        <location>
            <begin position="53"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="7">
        <location>
            <begin position="384"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU39918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="604" mass="64347" checksum="9194E5B7DE4B7E63" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8A8</accession>
    <name>C7Z8A8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_19379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045678.1">
        <property type="nucleotide sequence ID" value="XM_003045632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8A8"/>
    <dbReference type="GeneID" id="9672451"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_19379"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_19379"/>
    <dbReference type="eggNOG" id="ENOG502SNRY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2043686_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z8A8"/>
    <dbReference type="OMA" id="HMCAVYL"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="121" mass="13499" checksum="74B1B60E430296BE" modified="2009-10-13" version="1" fragment="single">SDTDFPSLVSKYKALRLSALQQTPNAFSSTYEAESKLPDHDWMARLRNQSKDTFVVVDSDGEWVAQVTVYGPVSAEAYTLPPEAGQPPIAPDEDEEKWQMLSLYVLPSHRGKGVAKLLCRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8U8</accession>
    <name>C7Z8U8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ketoreductase (KR) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_81636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045162.1">
        <property type="nucleotide sequence ID" value="XM_003045116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8U8"/>
    <dbReference type="GeneID" id="9673658"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_81636"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_81636"/>
    <dbReference type="eggNOG" id="KOG0940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1741041_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z8U8"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF272">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU39449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="16302" checksum="EF6E5B096077E23E" modified="2009-10-13" version="1">MQTTPNQEDLRGKWTDKIVMITGTSAGIGVETARTIATTGARIYLPVRSPSKIQEALRDLIETGQVTLLELDLNSLDSVRKAAATFLSMEKAATAKDLEGRGGLYLENLAPSEPAKLDAIAEKPGYAPWAFDEENEKKLWDLSLQLVGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9L5</accession>
    <name>C7Z9L5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_43700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045236.1">
        <property type="nucleotide sequence ID" value="XM_003045190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9L5"/>
    <dbReference type="GeneID" id="9673819"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_43700"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_43700"/>
    <dbReference type="eggNOG" id="KOG1290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_81_2_1"/>
    <dbReference type="InParanoid" id="C7Z9L5"/>
    <dbReference type="OMA" id="KQWALPE"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="94"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU39523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="480" mass="54765" checksum="42277E0A1BA46D2C" modified="2009-10-13" version="1">MATRGFKSLRRPSLTLVSGARRCFGLKGMVPRIATRGLATAAQVSQPTLMEDHNARLISMGYTFNYIEHVENLEQYCHGGFHPVSLGETLNNRYLILNKLGHGGYSTVWLSWDILKQKYAALKIVLADFGEDSTEVDILHHLAARPGSKYPGKSLIRHVTDNFHFDGPNGRHTCLVNDPAMMSLRLAKDASFCRLFQPRTARAIAAQVVQALAYLHEGGVVHGDLHLDNVLLRLPERIRHLSPDQLHKKHSQPETIPVTRLDGAPLNENAPHHAVLPIWLGQKSEEVTLADARILLGDFGESYRPSNEKRQYCNAPIRYRAPEVQFPDACQPLSFSSDIWSLGCLIWGVMGQRPLFDAWTLSEDEILRDQTDLLGEIPEEWSVYGRSQPEYWAEEDMDVTPVQSAERGFTWEDRLERSIQQSRRENGMKTMSENEKEAFIEMMKQMITFRPEDRASARELLESRWMRQWALPEVRRTRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9W7</accession>
    <name>C7Z9W7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal eL28/Mak16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_100986</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045287.1">
        <property type="nucleotide sequence ID" value="XM_003045241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9W7"/>
    <dbReference type="STRING" id="660122.C7Z9W7"/>
    <dbReference type="GeneID" id="9672242"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100986"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100986"/>
    <dbReference type="eggNOG" id="KOG3412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106801_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z9W7"/>
    <dbReference type="OMA" id="GKYGQRP"/>
    <dbReference type="OrthoDB" id="338850at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.110:FF:000002">
        <property type="entry name" value="60S ribosomal protein L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002672">
        <property type="entry name" value="Ribosomal_eL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10544">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="5">
        <location>
            <begin position="13"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="123"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU39574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="158" mass="17074" checksum="0340DF39B8D376C6" modified="2009-10-13" version="1">MPSAQLPNISSDLVWEIVRNNNSFSAKSKKNGGVQFSRDPLNLTNISSRKHAGFVNDKAVGISVGEKGEVVVTTKKAQPNKPAQNTTQTSYSAVKSNRKTYQAVANQVAKNSYRPDLRAAAVERASAVKRSNKPVKPEPEQKLRGNKAKKAAAAAEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAB5</accession>
    <name>C7ZAB5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_43471</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045362.1">
        <property type="nucleotide sequence ID" value="XM_003045316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAB5"/>
    <dbReference type="STRING" id="660122.C7ZAB5"/>
    <dbReference type="GeneID" id="9672317"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_43471"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_43471"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="InParanoid" id="C7ZAB5"/>
    <dbReference type="OMA" id="VYKYIQI"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF168">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU39649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="53061" checksum="C4601CA0126D462E" modified="2009-10-13" version="1">MSSVDGLRGLFDGVRPSIAIAGLLVGVLIFWSGISTWRQYNRLRAFKGPRLAGFSKWWLIRTVGSGRAYLDFWEVTKKYGSIARVSPNDLLTDDPDLMKHILNVRTEYRRSPWYDGMRFDPANNNILSWRDEDEHFKLRSKMSAGYGGREVENLEPKIDKNILAFIKLLRKYADEKKPVDLGRRAQFFTLDVLSDLAFGEPFGFLETDSDVYEYIKTTEETLPMVMVTTVVPWLVKVLSSPIFKSLLPSEKDRLGFGRVMGIAKAITAERFGPDKKVRKDMLGSFVAHGLTQKEAESEILLQIIAGSDTTATAIRSTMLHIITSPHVYNKLRTEISKTSYSEPIIPDSIGRDLPYLQAVIKEGLRIFPPVAGLMSKEVPPQGDTWKGQFIPGGTSVGYCAWGIFRREDIWGPDAGEFRPERWIESPPEKIKEMESALDLIFSYGRWQCLGRPVALMELNKIYVEVSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAC6</accession>
    <name>C7ZAC6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lysine-specific metallo-endopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_82052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045367.1">
        <property type="nucleotide sequence ID" value="XM_003045321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAC6"/>
    <dbReference type="GeneID" id="9672146"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82052"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82052"/>
    <dbReference type="HOGENOM" id="CLU_960063_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZAC6"/>
    <dbReference type="OrthoDB" id="4804857at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988949" description="Lysine-specific metallo-endopeptidase domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="32795" checksum="64A68456729EA499" modified="2009-10-13" version="1">MMLKKLLFFLGFLQAVIGQQRRIFVDTVSCSNRRTFVAIEESYHSAIRRAGLAIEALRPWAEGGAPINTFDGRIRNVFDLLFGAQNTRGNLLLVFSHLDRLPGIQYMGGDSTSRTMHDIPHNHPKEPNIHNWDTVQKRDFTRLVAGAGMKTPPRSSPFSPSKLYLTAALHGFPGNDVAFGGVRINQASVKAAANPRMHRWLFTHFGGWFERLRVTQIDLLDRLESSMLHELTHTTAGRLADDIELPNSYGWENCRRLQTHRNAALFALAVELINQYHYDVNAAGELTKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAF3</accession>
    <name>C7ZAF3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GH64 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_94692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045379.1">
        <property type="nucleotide sequence ID" value="XM_003045333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAF3"/>
    <dbReference type="GeneID" id="9672334"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94692"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94692"/>
    <dbReference type="eggNOG" id="ENOG502SJJ1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032886_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZAF3"/>
    <dbReference type="OMA" id="QYPAGWV"/>
    <dbReference type="OrthoDB" id="10058186at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd09220">
        <property type="entry name" value="GH64-GluB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.50">
        <property type="entry name" value="Beta-1,3-glucanase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032477">
        <property type="entry name" value="Glyco_hydro_64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037398">
        <property type="entry name" value="Glyco_hydro_64_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042517">
        <property type="entry name" value="Glyco_hydro_64_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38165">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38165:SF1">
        <property type="entry name" value="GLUCANASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16483">
        <property type="entry name" value="Glyco_hydro_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52006">
        <property type="entry name" value="GH64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH64" evidence="1">
        <location>
            <begin position="92"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="469" mass="50751" checksum="8B1B87D331564D87" modified="2009-10-13" version="1">MRRVRLKQFCFRGWSFSTRMRPFFVLAALVGTALAAPFQPSPIFRRHELTPQGFIKVNPGGANDLSMTDENMLNGTYPRNKTHALTHRAAEPATLPLKLVNNFSGGNVRAYISGLDSDGTVVFIGADGGLVYPRSGGSKIPVEITENIAIPLPPQGETLDFNIPISMSSGRIYFADDDLHFFMVDIGNGDGLVQPSTNNLQDPSAGVNWGFVELTYTNGVLYANISYVDFVGIVLGMMLSLTDGSTQTTAGLVADAASKICDDMVKQKDADGRAWTFLCIANALGDPIRVISPGNQYDLEPITFEDYWTSYVDEVWNKYSTQPLTINTQTEAGSVSCRVSGEELVCDGDNRGYAKPNTKDIWGCNSGPFAIIEGDNAIHTAVVPRLCAAFVRSTLLVDGGDVQPSLGADSYYKNDPTNHYSRIVHSYEVDGRGYAFPYDDVNPDGNENASGVVSGTPNTLTIYVGAPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAQ8</accession>
    <name>C7ZAQ8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_88905</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698913">
        <property type="protein sequence ID" value="EEU38887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044600.1">
        <property type="nucleotide sequence ID" value="XM_003044554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAQ8"/>
    <dbReference type="STRING" id="660122.C7ZAQ8"/>
    <dbReference type="GeneID" id="9672905"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88905"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88905"/>
    <dbReference type="eggNOG" id="ENOG502S5TA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013962_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZAQ8"/>
    <dbReference type="OMA" id="AHYAHMC"/>
    <dbReference type="OrthoDB" id="25921at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="9">
        <location>
            <begin position="265"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="96"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU38887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="611" mass="69426" checksum="40A1E86F4077BFB3" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAW5</accession>
    <name>C7ZAW5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_83041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044505.1">
        <property type="nucleotide sequence ID" value="XM_003044459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAW5"/>
    <dbReference type="GeneID" id="9670699"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83041"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83041"/>
    <dbReference type="eggNOG" id="ENOG502STP0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092471_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZAW5"/>
    <dbReference type="OMA" id="NGENACI"/>
    <dbReference type="OrthoDB" id="3853793at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046925">
        <property type="entry name" value="WD-like_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20493">
        <property type="entry name" value="WD-like_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WD-like" evidence="1">
        <location>
            <begin position="140"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="250" mass="26852" checksum="E757E1BB28B70D6D" modified="2009-10-13" version="1">MKTRFTRMATSAAAIAIGMALYEVFPAAHAMPTTGTDSHARNAASADFEDIYLSKVTAKIFGQDATHYDFSVISSEKALAVAAVHDYAAAFSEGNENKILVTFVNATMAGHLKVGQAEDTAWLCGELDEVMLPHVSQCAHIEKRDILEARSRWNWTKSTSHVASTFGAQVLAGYLGNLAWTVFPVSPRSVCSSGACLSWAQPLAGFTGYFAQQLVQDALSAADLNHYSVEAYRGVNNIDICISNRASGCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZB61</accession>
    <name>C7ZB61_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_45711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044465.1">
        <property type="nucleotide sequence ID" value="XM_003044419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZB61"/>
    <dbReference type="GeneID" id="9672768"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45711"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45711"/>
    <dbReference type="eggNOG" id="ENOG502QSKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_2_2_1"/>
    <dbReference type="InParanoid" id="C7ZB61"/>
    <dbReference type="OMA" id="HYWVTDF"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF106">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="27702" checksum="42790743B786BC42" modified="2009-10-13" version="1" fragment="single">RVLDVGTGTGIWAIDFADQFPSAQVIGTDISPIQPSWIPPNCEFHIDDAQLDWTWPTDHFDYIHVRDLYGSINDWSALYAKAFRHLKPGGWFEDLELDIRAHSDVVTDPEHIYHRWNAVFQEAGEKMGKTFKIAIGSRMRDLMDETGFVEVTERKFRLPMSAWASDPKLKEIGSFVQMFVDGGLEGFGLFLLTQVMGWPYDKCQVFIAEMRQALRNKKLNPYYEVTLVYGRKPEEATTTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBF6</accession>
    <name>C7ZBF6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_83162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044560.1">
        <property type="nucleotide sequence ID" value="XM_003044514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBF6"/>
    <dbReference type="GeneID" id="9670754"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83162"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83162"/>
    <dbReference type="eggNOG" id="ENOG502SAKP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047431_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZBF6"/>
    <dbReference type="OMA" id="WIVRLDF"/>
    <dbReference type="OrthoDB" id="5367135at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="48586" checksum="25D84B6DD42EB6B5" modified="2009-10-13" version="1">MVGSLVPKNLWHPDRQGGGSPGRERDKDPIRYGLNSLDDSVIGQAVVMLRFIKTGTEKGGNGFFVNIPGQDKAVIFTAGHNLIDENGQRTTQLRAWWKGVGTGWVDIAEKDTHISKVFSSKPTEASAIDDFGIILIPKNNNPPPPKTAFGFALRLAEEERIEGVCNISSYLTTARKDDPTTRSTGQFVNPILKQHQLEYLATTEAGVSGSVVWTGYNGKPVAVAIHNYGPKRKSPKYGSRGSRIDMKMMREIMEWTGVYKRAVAILAQPARKSQPTPTYPLCLSWSETDKILRVHVQDDTEPIPAEAVFEALPVYSSAMLLGDDPKVEYGFAQPDKRPSASKDALRWISWNVEWDSASFASSLGRARLARWEVKGKTALIALNWQDSITEVVVRTDDGVVKPWELEFPDSDYSGVAYQKRAFGTFKNSFNRFIFQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZC62</accession>
    <name>C7ZC62_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_76940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698918">
        <property type="protein sequence ID" value="EEU38314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044027.1">
        <property type="nucleotide sequence ID" value="XM_003043981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZC62"/>
    <dbReference type="GeneID" id="9670352"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76940"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76940"/>
    <dbReference type="HOGENOM" id="CLU_1835665_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZC62"/>
    <dbReference type="OrthoDB" id="10291925at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="140" mass="15444" checksum="387FB34EC584CE89" modified="2009-10-13" version="1">MCVHDEARTGRCGAEAALRPDGDGPGKFRNPKSPNEPRTPASTKSGGLKIEPNAWVAANHVSGKRCMEPVRKKRGGSVRSYLGPMEKSDLFSEPTRNWGLTIGAQSSLSSSEPPLLSLEARGRDWRSRRRHQAQRRLAHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCR0</accession>
    <name>C7ZCR0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_95905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698919">
        <property type="protein sequence ID" value="EEU38086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043799.1">
        <property type="nucleotide sequence ID" value="XM_003043753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCR0"/>
    <dbReference type="GeneID" id="9670161"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95905"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95905"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006937_6_1_1"/>
    <dbReference type="InParanoid" id="C7ZCR0"/>
    <dbReference type="OMA" id="PAHTYQA"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF7">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="541" mass="60462" checksum="011DFF213F303900" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDD9</accession>
    <name>C7ZDD9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_48339</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698919">
        <property type="protein sequence ID" value="EEU38083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043796.1">
        <property type="nucleotide sequence ID" value="XM_003043750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZDD9"/>
    <dbReference type="STRING" id="660122.C7ZDD9"/>
    <dbReference type="GeneID" id="9669894"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_48339"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_48339"/>
    <dbReference type="eggNOG" id="ENOG502SJS5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_4_0_1"/>
    <dbReference type="InParanoid" id="C7ZDD9"/>
    <dbReference type="OMA" id="VQWNSRC"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972:SF1">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972">
        <property type="entry name" value="MONOOXYGENASE ASQM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="327"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU38083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="422" mass="46252" checksum="20D36CBA10B4C1F8" modified="2009-10-13" version="1">MDDATPSHHFLEGKTIIVAGGGISGSAFVVGLRRLWNPAWNPPKILIYDRDSPEITAQREGYSLSLTGYNTSGGLLALRKLGLLDRIIDKAVSGLEGAGAFKIWAPDWKEYMTLRHEPIEGLPSSSIRVPRKDVRQAIHEGLGPSDAVEWNTLCVSAHRLDNGRVRVQVVRKTQGQDTVTDEDCDLLIAADGASSKLRAFLRPDDNLNFAGAILRGGISRFEHDPPAPVDKDWGFMLSGTGVSCFFSPVDKKSIFWGIGHLEDTPVPVLDLENPEQVQAVIDRGLELGAALQEPFRTIVAHTDPKTVLSHNARDKPAFSHGNIDELPVVLIGDSNHAVSPFAGFGANLALCDSWDLAEQLSKGRSLTEAISAYDKLAVPRAMKILKDSRSRLRSGHSSGLRYWILWLMLMVGNFVRWALGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZF30</accession>
    <name>C7ZF30_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Short-chain dehydrogenase/reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_86371</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043207.1">
        <property type="nucleotide sequence ID" value="XM_003043161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZF30"/>
    <dbReference type="FunCoup" id="C7ZF30">
        <property type="interactions" value="262"/>
    </dbReference>
    <dbReference type="GeneID" id="9665216"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86371"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86371"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="InParanoid" id="C7ZF30"/>
    <dbReference type="OMA" id="GTNYMGP"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU37494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="33470" checksum="DE5A6C9ADA06A751" modified="2009-10-13" version="1">MSFDPKNDIPDLSGKVIIVTGGSSGLGKESALQLAKHNPATIFVTARTEKRGSAAIKEIQDAAPNFKGQIKFLELDLSSFASIQKGATAFLGQSDRLDILMNNAGLMATPAGLTADGYEIQFGSNYMGPALFTKLLLPTIVKTAEQHGGDARVVNLSSELFKQAPKEGVLLSQCKTPLNNISSLARYGQSKLADYYHTRALSKFYPTVKFVAIHPGVVNTGLFDDFRKRRPWLGGLISVIGSIFLTDVHAGAKAQLWASTTKSQNVRSGGFYNQKLKEYKDAVLNDEKAVEELWDWTEKEFASKGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZF89</accession>
    <name>C7ZF89_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_37041</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698923">
        <property type="protein sequence ID" value="EEU37275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042988.1">
        <property type="nucleotide sequence ID" value="XM_003042942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZF89"/>
    <dbReference type="FunCoup" id="C7ZF89">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="GeneID" id="9665103"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_37041"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_37041"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_1_1"/>
    <dbReference type="InParanoid" id="C7ZF89"/>
    <dbReference type="OMA" id="PWKINAL"/>
    <dbReference type="OrthoDB" id="3357846at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="53"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU37275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="492" mass="53207" checksum="ABFAD3758A4206CA" modified="2009-10-13" version="1">MVSEPQPEVDYASSLEKGVYDGDGGRKLKVVGWYGESDPANPINWPKWKKALVVLTINFTAFVVYMASAIYTPSQPGVQSEFGVSATASSLGLGLFVVGYGTGSLFWSPVSEIPAVGRNGPYALTLAIFLILSVPTALSNSFGMLLAFRFLQGFFGSPILSTGGASLGDIADPYTKPYSLYTWAISSFAGPSVGTIMAGFTVPRLGWRWGLWEILIVVSPALALLLFLPETSAPTILYRRAKLIRQLTGSDSYVARSEIESSHVTLMTWFYGYLVIPWKINLLDPSIMFTSVYSGLTYAIFLSMFEFFPMVYGDIYGMAPGEIGLVLICNIVATIVAGVPYLAFVYYKVNPSVKQGRPMSPERRLLPAVIGSLLVPGGIFMFGWTSRPTIHWIVPTIGALLSSAGFIVIIQSIFVYVTLAYPTYAASLFAGNGFIKGLVACGGILWSHPLYQGLGLSKGMSVLGALCAACIAGTLILYTWGHKLRERSRFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFA6</accession>
    <name>C7ZFA6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_78398</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698923">
        <property type="protein sequence ID" value="EEU37187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042900.1">
        <property type="nucleotide sequence ID" value="XM_003042854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFA6"/>
    <dbReference type="GeneID" id="9665110"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78398"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78398"/>
    <dbReference type="eggNOG" id="ENOG502SUMD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_946957_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZFA6"/>
    <dbReference type="OMA" id="YHEMEGN"/>
    <dbReference type="OrthoDB" id="4770059at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="194"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU37187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="294" mass="30824" checksum="965DD49CA429A592" modified="2009-10-13" version="1">MAGEFGNPDRKSSLIEPLTTIWTIPGGCPSPVPLVDDNHTTLDSSCYPPDDWTIWESLGFYSPGICPRGYTSGCKVTDSAYGGTVRPTETAAICVPSSYSCSDYLIYASSVSGNDTITVPAFQIRWAKSDLTAFETSRSTSSSATSTSSSSSTSHPHPTGLPTGAIVGIALGSAAVVAILSGFMFFLFRRRGRRGTQKSHVSPDKNPPKDGLAELETPTQPAELATATRSSQGRGSVHELQQGGKSTIPELGGADGMLPELAGTLGTGGRHELGAEERSIPELEGNNGSRHELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFC3</accession>
    <name>C7ZFC3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Aquaglyceroporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_67872</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>glycerol(in) = glycerol(out)</text>
            <dbReference type="Rhea" id="RHEA:29675"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698923">
        <property type="protein sequence ID" value="EEU37218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042931.1">
        <property type="nucleotide sequence ID" value="XM_003042885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFC3"/>
    <dbReference type="STRING" id="660122.C7ZFC3"/>
    <dbReference type="GeneID" id="9665076"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_67872"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_67872"/>
    <dbReference type="eggNOG" id="KOG0224">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020019_9_0_1"/>
    <dbReference type="InParanoid" id="C7ZFC3"/>
    <dbReference type="OMA" id="WGFAVLT"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000027">
        <property type="entry name" value="MIP aquaporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF9">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02019">
        <property type="entry name" value="AQUAPORIN7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU37218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="37123" checksum="BE9C8559F31B683B" modified="2009-10-13" version="1">MTASFNQDSISESSFNSPSSPAKVEMVQTKALKELPSDSTLQPHVGEREEVLLWSRVRETCQDAFSEFFGTFVMILFGDGVVAQVVLSRGTKGDYQSISWGWGLGVMLGVYVGGKSGGHLNPAVTLANCIFRGHPWRKLPIYAIAQTLGAMAAAAVVYGNYKSAINAYEGGPGIRTVTGENATAGIFCTYPAAFMTRTGMVFSEFIASTILQFVIFALADSTNIGAGPLMPLALFFLIFGIGACWGWETGYAINLARDFGPRLVSYMIGYGTEVWSAGGYYFWIPMVIPFLGTSFGGFLYDTFMYTGPSPMNTPYMGLKRLVTPRRSVWSNTYDRALDSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFH3</accession>
    <name>C7ZFH3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_37284</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698923">
        <property type="protein sequence ID" value="EEU37244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042957.1">
        <property type="nucleotide sequence ID" value="XM_003042911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFH3"/>
    <dbReference type="STRING" id="660122.C7ZFH3"/>
    <dbReference type="GeneID" id="9665141"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_37284"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_37284"/>
    <dbReference type="eggNOG" id="KOG1404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_4_0_1"/>
    <dbReference type="InParanoid" id="C7ZFH3"/>
    <dbReference type="OMA" id="HKIPSHY"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005685">
        <property type="entry name" value="PRK07483.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094:SF1">
        <property type="entry name" value="AMINOTRANSFERASE CLASS-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU37244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="52406" checksum="3A38D518FA89BD00" modified="2009-10-13" version="1">MDSKNSLLYKNFHKHPAALVESASGIYLHTSDGRKILDATSGAAVACLGYDNKEVQKAVVDQLVSVPYCHPGFYKTKSAEDLADFLVDSTHGQMSKAVLCGSGSEAVEVALKLAKTHFSHLAIPQTERCHFIARVGAWHGATLGALTLGDFKVRKDPFVQLISQNSSRISACSTYRGLQKGETEEAYVQRLAQELDDEFQRVGPNKVCAFVAETVGGSASGCAMPVKGYFPAMKAVCEKYGALLILDEVMCGMGRTGSLHAFEQEDVVPDILVVGKGLGAGYAPISAVMLNTKLVESFQKSGKGFAHGQTYMAHPQAAAAGLKVQQVIRDTNMVAHVQRMGDYLGSKLKERLLPLPWVGDIRGRGLFWAVEFVIDKKSKEPFPYSLGLHGMLHSKGMSEGYEISLFNANGGYDGYSGDHFLICPPFIVNETDVDEIVDRTARVIEDTFSELVNSAVWEKIAIQMDIAAETPVAGIAVGETLVSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZGP8</accession>
    <name>C7ZGP8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_42111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698925">
        <property type="protein sequence ID" value="EEU36952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042665.1">
        <property type="nucleotide sequence ID" value="XM_003042619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZGP8"/>
    <dbReference type="STRING" id="660122.C7ZGP8"/>
    <dbReference type="GeneID" id="9670000"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_42111"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_42111"/>
    <dbReference type="eggNOG" id="ENOG502RW58">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106366_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZGP8"/>
    <dbReference type="OMA" id="SKVCHER"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU36952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="179" mass="20218" checksum="CC8B898270BE7F89" modified="2009-10-13" version="1" fragment="single">CSEEGFDILDDEHLCPICAPACRDALVNFRTKAKTACNTTKDAVAFKYNNIIFPPTYQVDLLLLSYDVYCYKDRDTGKFCDLELTKWRRRRDTNFPMECEDCSLGRWRKQLEAPIRYSDEDASLFSKSTSVCGATGYEYAKPTAQYATTLSMDMETSSRSHITPTPTPTSTPTPEQGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZGR5</accession>
    <name>C7ZGR5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RTA1 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_81136</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698925">
        <property type="protein sequence ID" value="EEU36959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042672.1">
        <property type="nucleotide sequence ID" value="XM_003042626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZGR5"/>
    <dbReference type="GeneID" id="9670085"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_81136"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_81136"/>
    <dbReference type="eggNOG" id="ENOG502RNSS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033465_0_1_1"/>
    <dbReference type="InParanoid" id="C7ZGR5"/>
    <dbReference type="OMA" id="QVFIYVC"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF34">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU36959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="39381" checksum="5616BCF0E78859B5" modified="2009-10-13" version="1">MGGAGEPIPYSLYVYAPNKGAPIFFTIAYAITTIFHVWQCHRYKAWKLVGLHCICGVMFTAGYAMREYGAYNYLYKTTTKLPLAIFITSQVCIYVCPPLLELANYHVLGRIFYYVPYCAPIAPGKVLATFGGLMGLVELLNSLGVSLSANTSSTPEKQALGSHLTIAAISLQLIIIIIFVYLACLFQRRCAKTNVQSTAVKTLLNTLYMSMALILVRCIYRLVEHTGNTKVDIDDVDSLMTLSPILRYEVFFYIFEAVLMLINSILWNIWHPGRFLPKDYHVYLSQDGTEVEGEEDSDDRPLIAKAGNVLTFGIFWRKKEQAQRFHQLDEYPGAQQQEGSRRCVSEEPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHE7</accession>
    <name>C7ZHE7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_6182</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698928">
        <property type="protein sequence ID" value="EEU36421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042134.1">
        <property type="nucleotide sequence ID" value="XM_003042088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHE7"/>
    <dbReference type="GeneID" id="9669246"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_6182"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_6182"/>
    <dbReference type="eggNOG" id="ENOG502S025">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_0_2_1"/>
    <dbReference type="InParanoid" id="C7ZHE7"/>
    <dbReference type="OMA" id="MRIPLHI"/>
    <dbReference type="OrthoDB" id="3648173at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="24"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU36421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="271" mass="30542" checksum="4D1294305993F3D0" modified="2009-10-13" version="1" fragment="single">EDRSATLIGVVVMLLIITTVVVVLRLWTRYVILNQLGPDDFLALISLLVVIGCGIAMILETRYGLGKHVSPSILETLPLYLKNFYVAVVLYAAALMFIKLTFLLHYYRLLAIQGMKKVYQAAIVLVGGWALSQVLVGIFICWPIQGFWDKSIDAKCIPNQPQWYINAAGNIVTDVMVFLLPIPAIRSLRLPRTQKFILGGIFSLGFFTVILSAIRIEYLKDFEDFTWKHVESNLWSMAELTSALVCACLPTLRPFVIRYFPTLASKFTRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZI73</accession>
    <name>C7ZI73_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_52478</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698929">
        <property type="protein sequence ID" value="EEU36340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042053.1">
        <property type="nucleotide sequence ID" value="XM_003042007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZI73"/>
    <dbReference type="GeneID" id="9674390"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_52478"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_52478"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_6_3_1"/>
    <dbReference type="InParanoid" id="C7ZI73"/>
    <dbReference type="OMA" id="NANTVWH"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF134">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="505"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="549"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="504"/>
            <end position="505"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU36340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="577" mass="63532" checksum="15DD8701C1B7C911" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZIE0</accession>
    <name>C7ZIE0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SDG2112</name>
        <name evidence="2" type="ORF">NECHADRAFT_122942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698930">
        <property type="protein sequence ID" value="EEU36245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041958.1">
        <property type="nucleotide sequence ID" value="XM_003041912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZIE0"/>
    <dbReference type="GeneID" id="9674280"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_122942"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_122942"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009043_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZIE0"/>
    <dbReference type="OMA" id="LKMETHH"/>
    <dbReference type="OrthoDB" id="1028014at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053209">
        <property type="entry name" value="Gramillin-biosynth_MTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643:SF2">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="365"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU36245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="647" mass="73474" checksum="9E897F396E0980D9" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZIG5</accession>
    <name>C7ZIG5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_52870</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698930">
        <property type="protein sequence ID" value="EEU36198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041911.1">
        <property type="nucleotide sequence ID" value="XM_003041865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZIG5"/>
    <dbReference type="GeneID" id="9674295"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_52870"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_52870"/>
    <dbReference type="eggNOG" id="ENOG502SIM5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057368_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZIG5"/>
    <dbReference type="OMA" id="LIIQQHM"/>
    <dbReference type="OrthoDB" id="5378633at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="24"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="274"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="333"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU36198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="349" mass="38942" checksum="ADAA84922A52C20A" modified="2009-10-13" version="1">MAEGLGQVISWYICTVVACLFLAARLWIRFRKFGSLAVDDGLIILATCCLIGDLVIQQHMWNLGMAEIPKASRENFIQIMKMIVPGSILYVSSLWAIKIALVLFYKRLAAPGTKLQIIYNVALGLLVVFWTVIFFHIIFQCFPHDKRWSQDPDYQCDPHNAEINYWLTIILNIGTDVAIISLPISMVLQLQMKMKQKLGVAAIFALGFFVVIASIIRAYYSKRNETMLTCTVSMIETAVAIIATCLPPLRTLFLGHMSSAGTGSNYGHYELSSAGANRSRRTQQSRITTNVVGGTSNRDNDSQDELVKETAGRPIDRTDKAGITVNTTIQMHHGRDENRRSRAEAGDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZIJ5</accession>
    <name>C7ZIJ5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_87166</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698930">
        <property type="protein sequence ID" value="EEU36275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041988.1">
        <property type="nucleotide sequence ID" value="XM_003041942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZIJ5"/>
    <dbReference type="GeneID" id="9674310"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87166"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87166"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_869023_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZIJ5"/>
    <dbReference type="OMA" id="GHIYKDS"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF178">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="102"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="131"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU36275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="320" mass="36735" checksum="E1F3A2CA7936EE0D" modified="2009-10-13" version="1">MHLGGTRRRPSVERDRSRVLDRRCYEPEGLLVHQRIAHDKVRKHLCEICGKRYISPAGLRNHQAGVHRRERPFPCSECPSAFLKQHFLDTHIATVHRKERKFICKGCGKGFGRKADMEAHFKRQHSQASARTCDECGEKVSSPSELVAHKNRKHNPEAKYMCDECGARFKRPRDLKNHESRHSDARPWKCQFPGCTKDYKTKDELGNHARKKGEKKAPGAVYTPIFHPEYCRDRVRADDLTMTPEQCADVLMTVLIQPEYGDGNIVETMLIGTRDNPSVNVREVPLELLYPTVGPVGQDNHLLEEEEKLADQLVKQGMRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZIU3</accession>
    <name>C7ZIU3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_53006</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698931">
        <property type="protein sequence ID" value="EEU36145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041858.1">
        <property type="nucleotide sequence ID" value="XM_003041812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZIU3"/>
    <dbReference type="STRING" id="660122.C7ZIU3"/>
    <dbReference type="GeneID" id="9674124"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_53006"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_53006"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_9_4_1"/>
    <dbReference type="InParanoid" id="C7ZIU3"/>
    <dbReference type="OMA" id="WNDCLDI"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF562">
        <property type="entry name" value="ALDEHYDE REDUCTASE II (AFU_ORTHOLOGUE AFUA_1G11360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="14"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU36145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="249" mass="27197" checksum="AC4F4E3A84760C43" modified="2009-10-13" version="1">MTNNVTAIPQGSWVLVTAANGHTGSHIVIELLKRGFKVRGTVRDLESSQWLLDDDSVAPYAKRGDLELLVADNSVPNAFDDVVKGVSAVIHVAIISDLVADPNIVIPATVEAALTVCRSAARESSVKRFIFTSTFWAATFPAPGISDTITNLDTWNEFALRAAWAPPPYEADRIIPVYCASKVEAEKAVWKFVKDEKLPWVVNSVSPCVILGDIRVDKHLRSVPPQLFEQLYLGNTAALQTPARESHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJ81</accession>
    <name>C7ZJ81_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_49685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698932">
        <property type="protein sequence ID" value="EEU35966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041679.1">
        <property type="nucleotide sequence ID" value="XM_003041633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJ81"/>
    <dbReference type="STRING" id="660122.C7ZJ81"/>
    <dbReference type="GeneID" id="9674087"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_49685"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_49685"/>
    <dbReference type="eggNOG" id="ENOG502T0DY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096182_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZJ81"/>
    <dbReference type="OMA" id="FEVEWPQ"/>
    <dbReference type="OrthoDB" id="5376498at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU35966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14529" checksum="509EB7D6BE61FB2B" modified="2009-10-13" version="1" fragment="single">EIGDAHISVRFKHGIHTIYLFVDSLEPFSSVTNQLLDVLTERYPNGLTTSIAPPKTTSVTEGAILAYGALKNANDPTAGWKKLRIGNGDTPNKLGLKNNSLIAFAVVDDEDEDPVFEVEWPREDEELYEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJY3</accession>
    <name>C7ZJY3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_87976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698936">
        <property type="protein sequence ID" value="EEU35712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041425.1">
        <property type="nucleotide sequence ID" value="XM_003041379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJY3"/>
    <dbReference type="GeneID" id="9676294"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87976"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87976"/>
    <dbReference type="eggNOG" id="ENOG502RZ6R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012207_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZJY3"/>
    <dbReference type="OMA" id="LATWKLE"/>
    <dbReference type="OrthoDB" id="3692311at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="587"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU35712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="686" mass="76296" checksum="5DE7DA4757B0A000" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZL97</accession>
    <name>C7ZL97_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_102898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698944">
        <property type="protein sequence ID" value="EEU35195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040908.1">
        <property type="nucleotide sequence ID" value="XM_003040862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZL97"/>
    <dbReference type="GeneID" id="9675238"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102898"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102898"/>
    <dbReference type="eggNOG" id="ENOG502S1C9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083054_0_1_1"/>
    <dbReference type="InParanoid" id="C7ZL97"/>
    <dbReference type="OMA" id="DFPYNYH"/>
    <dbReference type="OrthoDB" id="2923349at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050135">
        <property type="term" value="F:NADP+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053024">
        <property type="entry name" value="Fungal_surface_NADase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025331">
        <property type="entry name" value="TNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42059">
        <property type="entry name" value="TNT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42059:SF1">
        <property type="entry name" value="TNT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14021">
        <property type="entry name" value="TNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002987219" description="TNT domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="TNT" evidence="2">
        <location>
            <begin position="115"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU35195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="225" mass="24245" checksum="BE99B8E0E8F51D35" modified="2009-10-13" version="1">MRVSFFLSSLLWLSTASALPTSLDERKAVGCDCTGTQNGGPSAKEFICRDSRLGPKVLPKKLPLDNLVENYDRFGGLTPGQFLDKWTDDKGSFIYPPQNGFQLDQNGNAINGTMELQKGALVDRFGSEYGSFISAAAAPYSQRALPPSNLATNPSSPNFPYNYHVYRVLKPLPVVGGPIAPWFGQPGLGAQFFTGGVGNIMALIEKGYLESVDPSVLIFRGKGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLY9</accession>
    <name>C7ZLY9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Choline transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_37372</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698948">
        <property type="protein sequence ID" value="EEU34979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040692.1">
        <property type="nucleotide sequence ID" value="XM_003040646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLY9"/>
    <dbReference type="FunCoup" id="C7ZLY9">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="GeneID" id="9679091"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_37372"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_37372"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_2_4_1"/>
    <dbReference type="InParanoid" id="C7ZLY9"/>
    <dbReference type="OMA" id="GIPWIAF"/>
    <dbReference type="OrthoDB" id="2417308at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015101">
        <property type="term" value="F:organic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000046">
        <property type="entry name" value="Amino-acid permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF7">
        <property type="entry name" value="CHOLINE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU34979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="54975" checksum="AE10377395B8ED38" modified="2009-10-13" version="1">MKDHPDVEKVRTGSADSDAERLAEMGYSQDMKRNFSVWSVLGVGFSLTNSWWGVSAALITGVNSGGPCLLVYGTILLALVSVGVAVSLSELASAMPNAAGQIFWAAELAPRRYARAASYITGWLAWAGSICASASVALSISSAAVGCYQLSHPDFEIKTWHVVVCYQLANAFIFLFNCVGKLLPTIASISLYTTLISFAVILIAVPASAETHQDPKFVFATFINNTGWTQNGIAVIVGLINVNWGFSCLDTAIHLAEEVHSPEKMVPIAIMGTVTIGFITSFGFIISMLFSLTNFELVSTTVTGVPMLELFHQALRHKGGAIALEALIICTGAGCLAACHTWSSRLCWSFARDGGLPFSNFLARIHPRLGVPLNAHATSCVLASILGCLYLASIAAFNSILSGCIVLPYLSYSIPITFLLIRGRENIAHGPFWLGRFGLVSNIVLLCWVLFTFVMYSFPAYQPVEASNMNYVSVVYGIVFLIAVVDWVFRGKKAFEPPVGRHDEIEGVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMG7</accession>
    <name>C7ZMG7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_44711</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698953">
        <property type="protein sequence ID" value="EEU34744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040457.1">
        <property type="nucleotide sequence ID" value="XM_003040411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMG7"/>
    <dbReference type="STRING" id="660122.C7ZMG7"/>
    <dbReference type="GeneID" id="9678884"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_44711"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_44711"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_2_1"/>
    <dbReference type="InParanoid" id="C7ZMG7"/>
    <dbReference type="OMA" id="VHGVWSC"/>
    <dbReference type="OrthoDB" id="256333at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08254">
        <property type="entry name" value="hydroxyacyl_CoA_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
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    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050129">
        <property type="entry name" value="Zn_alcohol_dh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401:SF5">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
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        <property type="entry name" value="ADH_ZINC"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="8"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU34744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="329" mass="34624" checksum="003AA34EC3099721" modified="2009-10-13" version="1">MNAYRFSKPSKGLEYTKVPVPVPEPDQVLVEVKASGLCHTDLNIITGLDETFFWKRPITLGHEIAGVVVSIGSKVTKFKTGDRVVAVITNKHPIAVGDVIHAAGLGCDGGFAQFAALREEKTLLIPDAVTFAEAAVATDAVATAYHAVVTEGQVSASSKVAVVGLGGLGMSAIQIAARIGATVHGFDIDRHKFATALQSGAVVCGKSFDDLPGVKFDIVFDFVGTGSTTAEAVKAVKPEGKVVLVGLSSKESTIDTHQFVALGVRLVGSIGSSAKEVAETLQMIAEKQFTPLMEEIPFDKLPEGINRLTQGNVVGRLWTDPSKLKETGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNC1</accession>
    <name>C7ZNC1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_88345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698965">
        <property type="protein sequence ID" value="EEU34506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040219.1">
        <property type="nucleotide sequence ID" value="XM_003040173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNC1"/>
    <dbReference type="GeneID" id="9678042"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88345"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88345"/>
    <dbReference type="eggNOG" id="ENOG502S9D9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016014_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZNC1"/>
    <dbReference type="OrthoDB" id="5099367at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU34506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="601" mass="65133" checksum="6091C10DEE321396" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZP02</accession>
    <name>C7ZP02_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_101770</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039910.1">
        <property type="nucleotide sequence ID" value="XM_003039864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZP02"/>
    <dbReference type="GeneID" id="9677631"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101770"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101770"/>
    <dbReference type="eggNOG" id="KOG1397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001583_2_0_1"/>
    <dbReference type="InParanoid" id="C7ZP02"/>
    <dbReference type="OMA" id="LVCFVSW"/>
    <dbReference type="OrthoDB" id="16982at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF10">
        <property type="entry name" value="VNX1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="654"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="688"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="723"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="757"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="Inner membrane component" evidence="10">
        <location>
            <begin position="144"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="324"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="653"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="534"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="616"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU34197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="781" mass="86270" checksum="8D31D9E3DB17E3A7" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPG0</accession>
    <name>C7ZPG0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MoaB/Mog domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_85705</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>adenylyl-molybdopterin + molybdate = Mo-molybdopterin + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>molybdopterin + ATP + H(+) = adenylyl-molybdopterin + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:31331"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the MoaB/Mog family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039853.1">
        <property type="nucleotide sequence ID" value="XM_003039807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZPG0"/>
    <dbReference type="STRING" id="660122.C7ZPG0"/>
    <dbReference type="GeneID" id="9677786"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85705"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85705"/>
    <dbReference type="eggNOG" id="KOG2371">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010186_2_2_1"/>
    <dbReference type="InParanoid" id="C7ZPG0"/>
    <dbReference type="OMA" id="ESPYPMI"/>
    <dbReference type="OrthoDB" id="4349954at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061598">
        <property type="term" value="F:molybdopterin adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.190.11:FF:000002">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.980.10:FF:000011">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="entry name" value="MoeA, C-terminal, domain IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.10">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.190.11">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF045515">
        <property type="entry name" value="Glp_gephyrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192:SF5">
        <property type="entry name" value="GEPHYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="MOLYBDOPTERIN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="MoeA C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="MoeA N-terminal region -like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01078">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01079">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002989021" description="MoaB/Mog domain-containing protein" evidence="7">
        <location>
            <begin position="26"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="MoaB/Mog" evidence="8">
        <location>
            <begin position="9"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="MoaB/Mog" evidence="8">
        <location>
            <begin position="429"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="177"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU34140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="669" mass="69937" checksum="BAEA489CBF84CD7D" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQC2</accession>
    <name>C7ZQC2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_56032</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698987">
        <property type="protein sequence ID" value="EEU33795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039508.1">
        <property type="nucleotide sequence ID" value="XM_003039462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQC2"/>
    <dbReference type="GeneID" id="9667031"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_56032"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_56032"/>
    <dbReference type="eggNOG" id="ENOG502SHZM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008599_1_1_1"/>
    <dbReference type="InParanoid" id="C7ZQC2"/>
    <dbReference type="OMA" id="LQTMPEE"/>
    <dbReference type="OrthoDB" id="3362851at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="2"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU33795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="647" mass="73076" checksum="2D7A6960646ED979" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQM0</accession>
    <name>C7ZQM0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_89247</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699001">
        <property type="protein sequence ID" value="EEU33691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039404.1">
        <property type="nucleotide sequence ID" value="XM_003039358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQM0"/>
    <dbReference type="GeneID" id="9666925"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89247"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89247"/>
    <dbReference type="eggNOG" id="ENOG502RX41">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_816604_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZQM0"/>
    <dbReference type="OrthoDB" id="4891185at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU33691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="340" mass="35872" checksum="B27BB91CC0ABC37A" modified="2009-10-13" version="1">MLNEGEVAVGCCPSGYHCDPASPYYCFTTPRLGALITGVSYDPNCNATTTTSTLGTYSARRLYLIQPYNETALPLDDDASSGLPTVGKIVVGIVVPLIVILVSLAAFWLISRKKRHKESTQAREIHVNADGGDAVIKAELCGSEGTALAGPYSVAFEKPELENTPANSGSHAKASEMDVDPLDKGLLELKGSNNGGEKPRSTILELASSATQARAALSSDQPRDRVGDEALSGGQSQARARPAQEPDEGTMELWQWSNPLHTGESEKAVSTGSSLERPRRKAVVGQADAAQSKVPSSPDTKGQSPALSLELTTTSPPATQRREEEPKDGEPATGPDSTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZR19</accession>
    <name>C7ZR19_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_89388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699024">
        <property type="protein sequence ID" value="EEU33542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039255.1">
        <property type="nucleotide sequence ID" value="XM_003039209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZR19"/>
    <dbReference type="STRING" id="660122.C7ZR19"/>
    <dbReference type="GeneID" id="9666771"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89388"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89388"/>
    <dbReference type="eggNOG" id="ENOG502RH95">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146891_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZR19"/>
    <dbReference type="OMA" id="AEYFTIC"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU33542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="141" mass="16008" checksum="DCDBBB4AD1CC1259" modified="2009-10-13" version="1">MIQYFYSLNYEVSASGVDTGADLETHHQTAETSDGSLDESGFDLVVHTRTYNLVEKYQIIGLKTLALRKFRDAASEKWNSSGFLDAVYEAYGSAPENDTSLKEAIVEIIVEHKELLDKDGTRRMLKEVDFLAYDVLMYEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZRB1</accession>
    <name>C7ZRB1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_89479</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG699054">
        <property type="protein sequence ID" value="EEU33445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039158.1">
        <property type="nucleotide sequence ID" value="XM_003039112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZRB1"/>
    <dbReference type="GeneID" id="9666679"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89479"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89479"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006937_7_1_1"/>
    <dbReference type="InParanoid" id="C7ZRB1"/>
    <dbReference type="OMA" id="WHASEWP"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF4">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU33445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="585" mass="66914" checksum="62B4423197963164" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZRC1</accession>
    <name>C7ZRC1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_102313</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699059">
        <property type="protein sequence ID" value="EEU33435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039148.1">
        <property type="nucleotide sequence ID" value="XM_003039102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZRC1"/>
    <dbReference type="GeneID" id="9666672"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102313"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102313"/>
    <dbReference type="eggNOG" id="ENOG502SHBD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019316_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZRC1"/>
    <dbReference type="OMA" id="YNVKMLL"/>
    <dbReference type="OrthoDB" id="3990906at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF15">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="549"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="608"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="699"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="554"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="618"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="729"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU33435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="738" mass="83047" checksum="43D54530E8180129" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-04-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>H6D5E6</accession>
    <name>H6D5E6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LAGLIDADG intron encoded protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">atp6-i1</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="2"/>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="Fungal Genet. Biol." volume="49" first="2" last="14">
            <title>Comparative analysis of Fusarium mitochondrial genomes reveals a highly variable region that encodes an exceptionally large open reading frame.</title>
            <authorList>
                <person name="Al-Reedy R.M."/>
                <person name="Malireddy R."/>
                <person name="Dillman C.B."/>
                <person name="Kennell J.C."/>
            </authorList>
            <dbReference type="PubMed" id="22178648"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2011.11.008"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
            <strain evidence="2">MpVI</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JN041209">
        <property type="protein sequence ID" value="AEJ72915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H6D5E6"/>
    <dbReference type="STRING" id="660122.H6D5E6"/>
    <dbReference type="InParanoid" id="H6D5E6"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.28.10:FF:000010">
        <property type="entry name" value="LAGLIDADG homing endonuclease I-LtrII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051289">
        <property type="entry name" value="LAGLIDADG_Endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36181">
        <property type="entry name" value="INTRON-ENCODED ENDONUCLEASE AI3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36181:SF4">
        <property type="entry name" value="LAGLIDADG ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00961">
        <property type="entry name" value="LAGLIDADG_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homing endonuclease LAGLIDADG" evidence="1">
        <location>
            <begin position="69"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Homing endonuclease LAGLIDADG" evidence="1">
        <location>
            <begin position="231"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEJ72915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="359" mass="41607" checksum="E38D95EEC86A724B" modified="2012-04-18" version="1" fragment="single">NRSLCIFYYLSQTCLFEAPGLHSNLTFQISTYSSFNSDSQPYTQINISKDSPRYSFNNKNTFYLNPDYLTGFIDGEGCFSLSIFKDDRRLTGWQVKPVFSVSLHNKDIKLLEAIQRTFKTGKIYKHGADSMQYRVSSLKHLQIITDHFYSYPLITQKRADYLLFKQAISIIKNKEHLSTEGLLKLVGIKATLNWGLSDKFKESFPTVKAVVRPSVIYNTLNIKIKNLNWIRGFIDAEGSFQVITQNKTNVSLRFSLTQHIKDEELLKDITTYLYSGRYYKSPSRNEGQYLVTVFSDIYDKLIPFLNEYPLLGAKQDDYLDFAQIAELIKSKAHLTDEGLERIKLIQSNMNRKRTTIKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C7YH47</accession>
    <name>C7YH47_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_57415</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053567.1">
        <property type="nucleotide sequence ID" value="XM_003053521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YH47"/>
    <dbReference type="FunCoup" id="C7YH47">
        <property type="interactions" value="1377"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YH47"/>
    <dbReference type="GeneID" id="9664440"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_57415"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_57415"/>
    <dbReference type="eggNOG" id="KOG0358">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_9_1_1"/>
    <dbReference type="InParanoid" id="C7YH47"/>
    <dbReference type="OMA" id="HPAANMI"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03338">
        <property type="entry name" value="TCP1_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000010">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012717">
        <property type="entry name" value="Chap_CCT_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02342">
        <property type="entry name" value="chap_CCT_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU47854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="511" mass="54606" checksum="68D6BFC59C5208E4" modified="2009-10-13" version="1">MAVRSSNIVAARAVADAIRTSLGPRGMDKMIRGGKGETIITNDGNTMLKSMSVMHPTAKMLVNLSGAQDVEAGDGTTSVVVICGSLLGAADRLLSKGIHPSVISESFQRAAAAAVEVLHEMSLPIALTDTASLLQAANTSLSSKIVSQYSNLLGPMAVNSVTKTIDLKTADNVDLNNIRIVKRVGGTIEDSELVDGLVLTQPVLKNAGGPVRMEKAKIGLIQFQLSPPKPDMENTIQVNDYRQMDKIVKEERLYLLNMAKKIKKAKCNVLLIQKSILRDAVNDLSLHFLAKLGILAVKDIERDEVEFICKSTGCKPIADVDSFTEDKLGYADLVEEVQSSGSRMVKVTGTKSVGKTVSVVVRGANSLILEEAERSLHDALCVVRCLVKKKALIAGGGAPEIEIAAQLSKQARSLTGTEAICWKAFADALEVIPTTLAENAGLNSIKVVTELRHRHEMGEKNAGVSIKSGGVNTNISKENVLQPLLVSTSAIELAAETVKMILRIDDIALTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHA2</accession>
    <name>C7YHA2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphotransferase</fullName>
            <ecNumber evidence="12">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">hxk1</name>
        <name evidence="15" type="ORF">NECHADRAFT_105821</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="12"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054311.1">
        <property type="nucleotide sequence ID" value="XM_003054265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YHA2"/>
    <dbReference type="SMR" id="C7YHA2"/>
    <dbReference type="FunCoup" id="C7YHA2">
        <property type="interactions" value="906"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YHA2"/>
    <dbReference type="GeneID" id="9674468"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_105821"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_105821"/>
    <dbReference type="eggNOG" id="KOG1369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014393_5_2_1"/>
    <dbReference type="InParanoid" id="C7YHA2"/>
    <dbReference type="OMA" id="ADCVQQF"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046323">
        <property type="term" value="P:D-glucose import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990539">
        <property type="term" value="P:fructose import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1250:FF:000001">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000092">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000004">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="13">
        <location>
            <begin position="27"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="14">
        <location>
            <begin position="228"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU48598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="492" mass="54731" checksum="AF5EC07550CCFA18" modified="2009-10-13" version="1">MVGLGPRRPPSRKGSMADVPKDLADEIHKLEKLLTVDAAKLKEITNHFVSELAKGLSVEGGSIPMNPTWVMSFPDGYETGTYLALDMGGTNLRVCQITLTEEKSEFDIIQSKYRMPEELKSATSEELWDYIADCLFQFLETHHGDCTNMEKLPLGFTFSYPATQNYIDEGILQRWTKGFDIEGVEGENVVPMFEEALTRRGVPIKLAALINDTTGTLVASAYTDVDMKIGCIFGTGCNAAYFENCGSIPKLAHLNLPPDLPMAINCEWGAFDNEHKVLPRTPYDVIIDKESPRPGQQAFEKMIAGLYLGEIFRLIMVDLHDNKNVHIFENQDIALLRKPYSLDASFLSFIEEDPFENLQETYDLFSSKLNLACTRPELELIRKTAELIGTRAARLSACGVAAVCKKKNYETCHVGADGSVFNKYPYFKERGAQALREILDWPKKTNKRAEDPVEVLAAEDGSGVGAALIAALTLKRINEGNLAGILHPENFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHT2</accession>
    <name>C7YHT2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_75077</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TBCB family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053677.1">
        <property type="nucleotide sequence ID" value="XM_003053631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YHT2"/>
    <dbReference type="FunCoup" id="C7YHT2">
        <property type="interactions" value="717"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YHT2"/>
    <dbReference type="GeneID" id="9664715"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75077"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75077"/>
    <dbReference type="eggNOG" id="KOG3206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067577_2_0_1"/>
    <dbReference type="InParanoid" id="C7YHT2"/>
    <dbReference type="OMA" id="DQYEQRT"/>
    <dbReference type="OrthoDB" id="5295208at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01789">
        <property type="entry name" value="Ubl_TBCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045172">
        <property type="entry name" value="TBCB_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF85">
        <property type="entry name" value="TUBULIN-FOLDING COFACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="5">
        <location>
            <begin position="177"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU47964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="242" mass="26562" checksum="773149CA7CD39FB7" modified="2009-10-13" version="1">MADVPLVVISEYAQSERRITPSWSISQLKTKLETVTGIPPSCQRLSLKPTAGAEAIAVEAPNEDDTHLSNFPLAPYAELHVIDTRPAAARINLNDTTGVDKYVMPEEEYEKKTDSVLAWKKNQKLGRFDPSAPSHEQAKLDSLDREIATRGIAVGRRCRVGGEDTRRGVIQYVGEVKEIPGGLGSWVAVKLDEPVGKNDGSIGGTRYWGGPSELKHGVFVRPERVEVGDFPALDDLEDMEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHX5</accession>
    <name>C7YHX5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_31225</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053705.1">
        <property type="nucleotide sequence ID" value="XM_003053659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YHX5"/>
    <dbReference type="GeneID" id="9664730"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_31225"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_31225"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_315238_0_0_1"/>
    <dbReference type="InParanoid" id="C7YHX5"/>
    <dbReference type="OMA" id="QTWGMLL"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF39">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05010)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
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</entry>
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        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
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                <person name="Zhou S."/>
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</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
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                <person name="Rodriguez-Carres M."/>
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                <person name="Grimwood J."/>
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            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="704"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="835"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU48969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1022" mass="114111" checksum="6DDE16515416885C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJK3</accession>
    <name>C7YJK3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_75708</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054003.1">
        <property type="nucleotide sequence ID" value="XM_003053957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJK3"/>
    <dbReference type="STRING" id="660122.C7YJK3"/>
    <dbReference type="GeneID" id="9663860"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75708"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75708"/>
    <dbReference type="eggNOG" id="KOG0873">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_312855_0_0_1"/>
    <dbReference type="InParanoid" id="C7YJK3"/>
    <dbReference type="OrthoDB" id="5383967at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988363" description="Fatty acid hydroxylase domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="806"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="523"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="526"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU48290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="937" mass="104634" checksum="96EAA28984AE3D2C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJW5</accession>
    <name>C7YJW5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA mismatch repair protein MSH5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MutS protein homolog 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_714</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054058.1">
        <property type="nucleotide sequence ID" value="XM_003054012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJW5"/>
    <dbReference type="FunCoup" id="C7YJW5">
        <property type="interactions" value="167"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YJW5"/>
    <dbReference type="GeneID" id="9676681"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_714"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_714"/>
    <dbReference type="eggNOG" id="KOG0221">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002472_8_0_1"/>
    <dbReference type="InParanoid" id="C7YJW5"/>
    <dbReference type="OMA" id="CSVYFMP"/>
    <dbReference type="OrthoDB" id="29596at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051026">
        <property type="term" value="P:chiasma assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03281">
        <property type="entry name" value="ABC_MSH5_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001067">
        <property type="entry name" value="DNA mismatch repair protein MSH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF20">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="12">
        <location>
            <begin position="646"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU48345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="794" mass="86718" checksum="EBF38535FBD69277" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJX3</accession>
    <name>C7YJX3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_98630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053352.1">
        <property type="nucleotide sequence ID" value="XM_003053306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJX3"/>
    <dbReference type="GeneID" id="9676683"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_98630"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98630"/>
    <dbReference type="eggNOG" id="ENOG502S3S2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082191_2_0_1"/>
    <dbReference type="InParanoid" id="C7YJX3"/>
    <dbReference type="OMA" id="HNDPERP"/>
    <dbReference type="OrthoDB" id="3063476at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF1">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU47639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="131" mass="13857" checksum="010D9A126BFD8B5F" modified="2009-10-13" version="1">MIASHGRGGAGNMADTAHTPKTNPADLQTPVLRGSVVTTGRGGTGNMAKNDDPRETRKRQDVEAVFRRPSAGAQHAGRGGAGNVFKDSDEELTRRPSNDNAIAEDDEPVKHAPATESLAQKGKNWLFGKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>C7YM32</accession>
    <name>C7YM32_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_99622</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the bZIP family. YAP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052586.1">
        <property type="nucleotide sequence ID" value="XM_003052540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YM32"/>
    <dbReference type="FunCoup" id="C7YM32">
        <property type="interactions" value="3155"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YM32"/>
    <dbReference type="GeneID" id="9663937"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_99622"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_99622"/>
    <dbReference type="eggNOG" id="ENOG502RPD7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011807_0_0_1"/>
    <dbReference type="InParanoid" id="C7YM32"/>
    <dbReference type="OMA" id="LNMACGN"/>
    <dbReference type="OrthoDB" id="5380163at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000067">
        <property type="entry name" value="BZIP transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.100">
        <property type="entry name" value="YAP1 redox domain. Chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013910">
        <property type="entry name" value="TF_PAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023167">
        <property type="entry name" value="Yap1_redox_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08601">
        <property type="entry name" value="PAP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111430">
        <property type="entry name" value="YAP1 redox domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="158"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="95"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="260"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="272"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="359"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU46873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="582" mass="62978" checksum="EA768BBEA5C25602" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7YM37</accession>
    <name>C7YM37_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Riboflavin kinase</fullName>
            <ecNumber evidence="4">2.7.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Flavin mononucleotide kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">NECHADRAFT_99626</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>riboflavin + ATP = FMN + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="4"/>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052589.1">
        <property type="nucleotide sequence ID" value="XM_003052543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YM37"/>
    <dbReference type="FunCoup" id="C7YM37">
        <property type="interactions" value="415"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YM37"/>
    <dbReference type="GeneID" id="9671121"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_99626"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_99626"/>
    <dbReference type="eggNOG" id="KOG3110">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048437_3_2_1"/>
    <dbReference type="InParanoid" id="C7YM37"/>
    <dbReference type="OMA" id="FDCEVAR"/>
    <dbReference type="OrthoDB" id="276388at2759"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749:SF6">
        <property type="entry name" value="RIBOFLAVIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="RIBOFLAVIN KINASE/FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Riboflavin kinase" evidence="15">
        <location>
            <begin position="16"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEU46876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="210" mass="22685" checksum="353DF822EBECE87D" modified="2009-10-13" version="1">MSSRPSIVGPDAGPDAPYPLHMEGNVISGFGRGSKELGIPTANLPVDAALTPWIADMPSGVYFGYASLALPSTHPDHPDATTSKDAPSSNEAALLASAPQSNPPFHIFPMVMSIGYNPFYKNTVRSAEVHVLHKFTADFYDVPMRLLILGFIREEKDYKSLDALIEDINFDCEVAKNSLAREGWVPSKGRVIGGASLDGKLDAQWLTRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7YMN7</accession>
    <name>C7YMN7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alcohol dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_92038</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052695.1">
        <property type="nucleotide sequence ID" value="XM_003052649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YMN7"/>
    <dbReference type="GeneID" id="9671227"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_92038"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_92038"/>
    <dbReference type="eggNOG" id="ENOG502QT3Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021479_0_0_1"/>
    <dbReference type="InParanoid" id="C7YMN7"/>
    <dbReference type="OMA" id="IWVGATN"/>
    <dbReference type="OrthoDB" id="5302359at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000424">
        <property type="entry name" value="Meiotically up-regulated gene 72 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF25">
        <property type="entry name" value="PROTEIN PAM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="3">
        <location>
            <begin position="199"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="666"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="739"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU46982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="769" mass="83321" checksum="D422AF004F263CAD" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7YMU3</accession>
    <name>C7YMU3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_35841</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052725.1">
        <property type="nucleotide sequence ID" value="XM_003052679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YMU3"/>
    <dbReference type="GeneID" id="9664209"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_35841"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_35841"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_13_3_1"/>
    <dbReference type="InParanoid" id="C7YMU3"/>
    <dbReference type="OMA" id="MYTTHLA"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF16">
        <property type="entry name" value="BACILYSIN BIOSYNTHESIS OXIDOREDUCTASE BACC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU47012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="356" mass="38786" checksum="D4316D5B23FC3178" modified="2009-10-13" version="1">MATENRDITALIRQSPPIDVSKPYDPTSLKGKTILITGGANGLGAHMVREWASHGAHVVIGDVADAAGEDLVAALRTSYPDSTFAFQHCDVTDWESQVSLFETAVRVSPHGGIDVVVPNAGIILPGHSMKFEAPVLKDGRIPKPNMATFDVNIVGATYTTHLAFYWLPKNEVSEGRDRCLLLIGSLASLCPFPGQCYYTMSKHAILGLFRTLRATSWRQGIRVNMIAPYYTSKSNMLKPEVEAMFLSGTAGGAEIEDVIDAATRLVADEAVKGRALCVGPKLRTVDVKVVEDEDELMVVGEAEGNGKGRAVWECYAEDYSNADAFVKRFVLLLNAAERVKGWLGVLSDIWGIFRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNX3</accession>
    <name>C7YNX3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit delta, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">F-ATPase delta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">NECHADRAFT_60460</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052364.1">
        <property type="nucleotide sequence ID" value="XM_003052318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNX3"/>
    <dbReference type="FunCoup" id="C7YNX3">
        <property type="interactions" value="752"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YNX3"/>
    <dbReference type="GeneID" id="9672983"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_60460"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_60460"/>
    <dbReference type="eggNOG" id="KOG1758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084338_0_0_1"/>
    <dbReference type="InParanoid" id="C7YNX3"/>
    <dbReference type="OMA" id="PHQTIYR"/>
    <dbReference type="OrthoDB" id="270171at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048938">
        <property type="entry name" value="ATPD_C_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21334">
        <property type="entry name" value="ATPD_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="14">
        <location>
            <begin position="36"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="F1F0-ATP synthase subunit delta C-terminal" evidence="15">
        <location>
            <begin position="122"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEU46651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="165" mass="17626" checksum="EEFF0F9ACBD855FC" modified="2009-10-13" version="1">MNSLRFARAALRARPAAIRVPLQRRTYAEAVPDKIKLSLALPHQAIYKSQDVVQVNIPAESGEMGVLANHVPSIEQLKPGLVEVIEESGGAKQFFLSGGFATVQPNSILSINAVEGFPLEDFSADAVRAQIAEAQKVASGSGSEQDIAEAKIELEVLETLAAHVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7YP62</accession>
    <name>C7YP62_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Jacalin-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_103976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051955.1">
        <property type="nucleotide sequence ID" value="XM_003051909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YP62"/>
    <dbReference type="FunCoup" id="C7YP62">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="GeneID" id="9673108"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_103976"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_103976"/>
    <dbReference type="eggNOG" id="KOG4525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009601_2_1_1"/>
    <dbReference type="InParanoid" id="C7YP62"/>
    <dbReference type="OMA" id="MFRNNFG"/>
    <dbReference type="OrthoDB" id="74460at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001229">
        <property type="entry name" value="Jacalin-like_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053002">
        <property type="entry name" value="Metalloproteinase_M10B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021917">
        <property type="entry name" value="Unchr_Zn-peptidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054:SF2">
        <property type="entry name" value="MIP04191P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054">
        <property type="entry name" value="ZINC METALLOPROTEINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01419">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12044">
        <property type="entry name" value="Metallopep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00915">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51752">
        <property type="entry name" value="JACALIN_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Jacalin-type lectin" evidence="2">
        <location>
            <begin position="635"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU46242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="780" mass="85421" checksum="C95FDBF0E6C80314" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPA3</accession>
    <name>C7YPA3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zinc/iron permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_38445</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051977.1">
        <property type="nucleotide sequence ID" value="XM_003051931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YPA3"/>
    <dbReference type="STRING" id="660122.C7YPA3"/>
    <dbReference type="GeneID" id="9668599"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_38445"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_38445"/>
    <dbReference type="eggNOG" id="KOG1558">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027089_5_0_1"/>
    <dbReference type="InParanoid" id="C7YPA3"/>
    <dbReference type="OMA" id="QYTGCHS"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF44">
        <property type="entry name" value="PROTEIN ZNTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988184" description="Zinc/iron permease" evidence="7">
        <location>
            <begin position="24"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU46264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="50981" checksum="1CDE51437B25D3FD" modified="2009-10-13" version="1">MYTPVSSLAKWGILVSTAASAAANLAPRATTAATTTASEAKVTAITGCHLHASDLYCFAGETEYLVDIKVTATTDVPAKYTDCHSHGSEMYCVDSDGEDVAEGHEEEEAAEADENEHCHFHAGVEHCTGGSDSESESSEAGSSSSSSCQPRQRDYNIGLRVGLLFVILATSAIGVFGPILLHKMMPTKLNLVLIVLKQFGTGIIISTAFVHLFTHAFLMFSNECIGELGYEATTAAIVMAGLFLSFLVEYIGHRVVLAKAKASAALSSTERKSVFLSTEVLSILVMEAGIIFHSLLIGLTLVVSGDEYFITLFIVILFHQMFEGIALGSRIATIGTAADAEVVTAARPSQETSSAQDSDKAPCPAETTSCEEVAPPTGLTLRKKLGLAALFAFTTPIGMAIGIGVLQQFNGNDKSTIIAIGTLDALSAGILVWVGLVEMWAADWMTGNHGQKAELADADILTTVLAFTGLVAGLVVMSLLGKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPE9</accession>
    <name>C7YPE9_FUSV7</name>
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        <recommendedName>
            <fullName evidence="8">DUF726 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_38994</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051546.1">
        <property type="nucleotide sequence ID" value="XM_003051500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YPE9"/>
    <dbReference type="GeneID" id="9668623"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_38994"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_38994"/>
    <dbReference type="eggNOG" id="KOG2385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007407_1_0_1"/>
    <dbReference type="InParanoid" id="C7YPE9"/>
    <dbReference type="OMA" id="KDIHWED"/>
    <dbReference type="OrthoDB" id="277931at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF22">
        <property type="entry name" value="DUF726 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G12860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU45833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="622" mass="68114" checksum="CCD6A4A8FB5DCC3D" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPL1</accession>
    <name>C7YPL1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_92536</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="interactions" value="112"/>
    </dbReference>
    <dbReference type="GeneID" id="9668732"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_92536"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_92536"/>
    <dbReference type="eggNOG" id="KOG4510">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032828_4_3_1"/>
    <dbReference type="InParanoid" id="C7YPL1"/>
    <dbReference type="OMA" id="PIASCYV"/>
    <dbReference type="OrthoDB" id="306876at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER G1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="107"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="280"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="432"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU45866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="460" mass="49947" checksum="F69C9A349A67D09E" modified="2009-10-13" version="1">MGSVPPPYEEIPQTPGAKLAPGNVGQSDRHLLPVPSPSPSLMGTKLDDSNYDEFRRLSLSPSPCPSPIPMGRLPHNGTELQGDATPTRWQVFWTRNKPAALVALSQFFGALMNLSARLVELEGNGMHPVQVLLMRQFMTACCCSAYMWWSKTPDFPFGKREIRWLLWLRGLSGYWGIYGMWYSMMYLPLADATVITFLAPGVAGFICWFALREPFTRIEQLATLVALLGVVLIARPTSLFSHSGEDQDPSTTEPPEGGIPGADHEATSEERLVAVGVALVGVLGAAGAFTTLRTIGKRAHPLISVNYFGAISTIISALFLIFAPILDVAQPGLRWVTPSTAKQWLLLLPLGILGFIMQYLLTSGLGADKSNRANAMVYTHMLFAASFDRWVFGHRMGLMSGAGCTLILGSAIGVVLIKKSPPPKVPADDIERHGNLVGEAEGSPMLLPDSGTSEEMRISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPZ7</accession>
    <name>C7YPZ7_FUSV7</name>
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        <submittedName>
            <fullName evidence="3">Bacterial-type extracellular deoxyribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_92629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051650.1">
        <property type="nucleotide sequence ID" value="XM_003051604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YPZ7"/>
    <dbReference type="STRING" id="660122.C7YPZ7"/>
    <dbReference type="GeneID" id="9668879"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_92629"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_92629"/>
    <dbReference type="eggNOG" id="ENOG502QWPZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043034_3_1_1"/>
    <dbReference type="InParanoid" id="C7YPZ7"/>
    <dbReference type="OMA" id="ASYYCTY"/>
    <dbReference type="OrthoDB" id="3162605at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="GmrSD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24094:SF15">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24094">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="GmrSD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988553" evidence="1">
        <location>
            <begin position="17"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="GmrSD restriction endonucleases C-terminal" evidence="2">
        <location>
            <begin position="99"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU45937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="200" mass="21691" checksum="A3CF1C894F5C2073" modified="2009-10-13" version="1">MKFSLALLVSATGALAAPTPPGIPTESTARSLLSGLTVGTPTNTDTYDRDLFPHWETVSGACNTREFVLQRDGTNVVTNSACAATSGTWRSPYDGATWTAASDVDIDHMVPLQNAWISGAASWTTAKRRDFANDITRPQLWAVTDNVNQAKGSATPATWKPPLTSFYCTYAKSWIQVKSYWQLAITSAEKTALTDMLNYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQ57</accession>
    <name>C7YQ57_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_37522</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052126.1">
        <property type="nucleotide sequence ID" value="XM_003052080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQ57"/>
    <dbReference type="FunCoup" id="C7YQ57">
        <property type="interactions" value="242"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YQ57"/>
    <dbReference type="GeneID" id="9673429"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_37522"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_37522"/>
    <dbReference type="eggNOG" id="ENOG502QQZ4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015811_2_0_1"/>
    <dbReference type="InParanoid" id="C7YQ57"/>
    <dbReference type="OMA" id="DEIQNTW"/>
    <dbReference type="OrthoDB" id="4161332at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU46413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="663" mass="74380" checksum="C575D3AC4E75567C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQT0</accession>
    <name>C7YQT0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_79214</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052239.1">
        <property type="nucleotide sequence ID" value="XM_003052193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQT0"/>
    <dbReference type="FunCoup" id="C7YQT0">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="GeneID" id="9672700"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79214"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79214"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_3_1"/>
    <dbReference type="InParanoid" id="C7YQT0"/>
    <dbReference type="OMA" id="QAFSYTF"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF84">
        <property type="entry name" value="VACUOLAR MEMBRANE AMINO ACID UPTAKE TRANSPORTER FNX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="4"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU46526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="496" mass="52862" checksum="8730C71A15DB2C21" modified="2009-10-13" version="1">MHLILPAVGIGVYMVAIDQLLTVATYAKIGNELNALNNTSWIATAYFLTLTSFQPLYGKLSDIFGRKPCLLFAYTIFAVGCLGCGLAQSMVQLCAARAVAGVGGGGMNAVVSILLSDLVPLRERGMWQGCINILWAAGTSTGAPLGGLLADSVGWRWSFLGQVPLCFVAFVAVYFVLDLPPVSHDHWLTKVRQIDFLGAFTLVIAVVALLAGLDSGSNLGWSHIITIVALSLAPVLFGLFLFVEMKVASNPFAPGHIIFDRSLFACYLVNFFGVAGQMAILFFIPLFFQAVQGLTATQSGALLVPGMIAGVIASLLGGWIIKRTEKFYAITVSAYALLFVAALPLGLSVWFRSTTGEVIGLVATSLGAGCGITTTLVGLLANAAVEDTAVVVACSYLFRSLGSSIGISTGSAVLQQVLRTQLASRLPNGDEAREIEENVRQSLDYIKELPPHLAAQVRSSYQVATLGAMALITIYLGVSFLTAFWIKERPLKRYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRK3</accession>
    <name>C7YRK3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_40480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050803.1">
        <property type="nucleotide sequence ID" value="XM_003050757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YRK3"/>
    <dbReference type="STRING" id="660122.C7YRK3"/>
    <dbReference type="GeneID" id="9665896"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_40480"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_40480"/>
    <dbReference type="eggNOG" id="ENOG502RDJ2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008050_0_0_1"/>
    <dbReference type="InParanoid" id="C7YRK3"/>
    <dbReference type="OMA" id="RIEMTYY"/>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052981">
        <property type="entry name" value="Ingression_C2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052">
        <property type="entry name" value="CONSERVED SERINE PROLINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_2G01790)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052:SF3">
        <property type="entry name" value="INGRESSION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="11"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="398"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="561"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="737"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="820"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="854"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="876"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU45090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="951" mass="105153" checksum="C1E1A11D8CEC9F8D" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSX5</accession>
    <name>C7YSX5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_104591</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051437.1">
        <property type="nucleotide sequence ID" value="XM_003051391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSX5"/>
    <dbReference type="STRING" id="660122.C7YSX5"/>
    <dbReference type="GeneID" id="9666345"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_104591"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_104591"/>
    <dbReference type="eggNOG" id="KOG0683">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017290_0_1_1"/>
    <dbReference type="InParanoid" id="C7YSX5"/>
    <dbReference type="OMA" id="NIMTFRL"/>
    <dbReference type="OrthoDB" id="77835at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006576">
        <property type="term" value="P:biogenic amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000013">
        <property type="entry name" value="Glutamine synthetase bacteria"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000005">
        <property type="entry name" value="Probable glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
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        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785">
        <property type="entry name" value="GAMMA-GLUTAMYLPUTRESCINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785:SF12">
        <property type="entry name" value="TYPE-1 GLUTAMINE SYNTHETASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS catalytic" evidence="8">
        <location>
            <begin position="124"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU45724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="482" mass="53525" checksum="8A9304AC32893C0A" modified="2009-10-13" version="1">MASELFPDTITPETLPQLLQSDTMVKVAGVDVDGILRGKLVSKKKFLSIAEAGFGFCSVIFGWDMHDKTYIRELKISNAENGYHDLLAVPDLSTFRRIPWEDNVPFFLVDFLDPDTKKPICACPRGLIKTQLDKLKSHGYGAMAGAEYEFYQFKNPDPSTSSPAAYLQENPPHQLPALTEGMFGYSLTRPVHNQEYYYDVFNTCAQFSCDIEGWHTESGPGVFEAALEFGEISQMADRAALFKYVVKSVSTKYGITPCFMAKPKQGLPGNSGHMHVSLVDKAGKNLFARDTLDENAQWKDIAGLSDLGRHFLAGILVGLPDIMPLLAPTINSYKRLVENFWAPVTVSWGLEHRAASIRLITPPTSKPSATRFEVRVPGADTNPHFVLAAVLGCGWRGVEKKLEIPTPPLAMGQDVGGEADQGERLAKSLKEATTRFMAKGSIAREVFGDDFVEHFGGTREHEIRLYDEAVTDWEMKRYIETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7YTD4</accession>
    <name>C7YTD4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_96046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050313.1">
        <property type="nucleotide sequence ID" value="XM_003050267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YTD4"/>
    <dbReference type="GeneID" id="9675098"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_96046"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_96046"/>
    <dbReference type="eggNOG" id="ENOG502RYFN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047435_0_0_1"/>
    <dbReference type="InParanoid" id="C7YTD4"/>
    <dbReference type="OMA" id="YSDHLHP"/>
    <dbReference type="OrthoDB" id="9971601at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36142">
        <property type="entry name" value="METALLO-HYDROLASE/OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36142:SF2">
        <property type="entry name" value="METALLO-HYDROLASE_OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU44600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="39499" checksum="A30732F4C6B7D64B" modified="2009-10-13" version="1">MSERRRGVLQTQLSSAEKQPRPVLTSLNGDNSWLMSFPRPEAERAAAGKVFYHVVFEPWLEGPTSMLGWWMINITLSSSPGILDVEAVKGVVREIEDAAAIHLPQSGDASAKASTEESDSGGIDAILLSFYLLDHVHEATLRTFSKDIPVIATPEAANIVRPWGHFETIKVIQDLQPLVQSWRTPELHPGKPLPVWLTPIRLPGFAVLNFSLAIVWTHTTNDEGEVHEVILTSPHGTRFEGSLEAFRNAEPKTKMLAMLHGLKESYTFGRQTTLGAKGGLELYRKIGGVKYWILSHHSKLLYGGIFMYLSWTQDTHRTVSWMLEEEQKVDPDSAKKERPNIVEVDNGGSFVLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7YTJ8</accession>
    <name>C7YTJ8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_84607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84607"/>
    <dbReference type="eggNOG" id="ENOG502SSMB">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052635">
        <property type="entry name" value="Sec_Metab_Biosynth_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607">
        <property type="entry name" value="XANTHOCILLIN BIOSYNTHESIS CLUSTER TRANSCRIPTION FACTOR XANC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
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            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
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            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
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            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
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        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
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        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU44633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="275" mass="30997" checksum="D6196AE65E30B59F" modified="2009-10-13" version="1">MSSPRYSASDLQPPEIRIQSASPEVPQAQQSQYQYLYEEELEASEELEQPRRAKSLPSETPREGHRRHRKKRSSNTAHLETPEVDPRNNKMAGSSKHSSSSSRKGSSSSSSSKKSKSSPKDDLDWTDVTDPEERRRIQNRIAQRKFREKARENKEKAERDSRNQEYAGNSYRIPNPGDFSTDPEPSGLPWGSVNIAHFVARGQEVESRRSSGRGTYSGDDGFATATYGASPSYGGAQWTQHTSYGGSSGGDEMYYDDSYLFWYLKHRGGLKWNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7YTU0</accession>
    <name>C7YTU0_FUSV7</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_63485</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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            <taxon>Fusarium vanettenii</taxon>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="FunCoup" id="C7YTU0">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YTU0"/>
    <dbReference type="GeneID" id="9674803"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_63485"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_63485"/>
    <dbReference type="eggNOG" id="KOG3680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003184_0_0_1"/>
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    <dbReference type="OMA" id="KMTRAMR"/>
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        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040185">
        <property type="entry name" value="Far11/STRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021819">
        <property type="entry name" value="Far11/STRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012486">
        <property type="entry name" value="Far11/STRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239:SF4">
        <property type="entry name" value="AT25231P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239">
        <property type="entry name" value="PROTEIN REQUIRED FOR HYPHAL ANASTOMOSIS HAM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11882">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07923">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01293">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01292">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="100"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Far11/STRP C-terminal" evidence="3">
        <location>
            <begin position="499"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="690"/>
        </location>
    </feature>
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        <location>
            <begin position="780"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="661"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU44305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1022" mass="114376" checksum="BCBA2EA9664D48BF" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7YU76</accession>
    <name>C7YU76_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_84827</name>
    </gene>
    <organism evidence="9 10">
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        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003050420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YU76"/>
    <dbReference type="GeneID" id="9665439"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84827"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84827"/>
    <dbReference type="eggNOG" id="ENOG502SN0C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_29_1_1"/>
    <dbReference type="InParanoid" id="C7YU76"/>
    <dbReference type="OMA" id="NYHNERI"/>
    <dbReference type="OrthoDB" id="5283415at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="2"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="243"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU44753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="350" mass="39394" checksum="4638F029203B4E7F" modified="2009-10-13" version="1">MAMALSIAETICSYYSMRLNYIGIHKKDIPLTQDFVLGQKWAFTIQILYNPILALVKTSVLLFLMRLGGQKREVRLCIISLLVFNLFQMVAMFFACVFQCTPVSYFWNRAKEESVRPDGMCINQNAFYIATSSLTILTDVLVLILPFWIFLGLKLPLKVRAAIIGVFVLGGAVTIMSILRMSWLIETAYFIDFTDPDLDWSYDIRFTYSAVETNLAIITASAPALRPLFLQWFPKFFSALKSSGNKYSSTRDGYGRSTTTGTAKRSRGGTGVRSSLAGPFPLKDIKGRSEIRSHSPTNSEEEIMTYNGILKTSEVAVQYGERVPATHLRDDSETESSRYGFGPRASHDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C7YUJ8</accession>
    <name>C7YUJ8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Altered inheritance of mitochondria protein 32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_84947</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AIM32 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050136.1">
        <property type="nucleotide sequence ID" value="XM_003050090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YUJ8"/>
    <dbReference type="STRING" id="660122.C7YUJ8"/>
    <dbReference type="GeneID" id="9674921"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84947"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84947"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_368446_0_0_1"/>
    <dbReference type="InParanoid" id="C7YUJ8"/>
    <dbReference type="OMA" id="CGCAATP"/>
    <dbReference type="OrthoDB" id="10253744at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF7">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="420"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU44423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="756" mass="82719" checksum="8548392A39C8A5E1" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C7YUL2</accession>
    <name>C7YUL2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_84960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050538.1">
        <property type="nucleotide sequence ID" value="XM_003050492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YUL2"/>
    <dbReference type="GeneID" id="9674928"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84960"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84960"/>
    <dbReference type="HOGENOM" id="CLU_1304920_0_0_1"/>
    <dbReference type="InParanoid" id="C7YUL2"/>
    <dbReference type="OrthoDB" id="5002369at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU44825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="240" mass="27858" checksum="8EE6BD2F474BF7AE" modified="2009-10-13" version="1">MDPAIRAQFLESPLYRDFKTAFQHIMEKKIKNSQEVQQNEVLEPYYYITGLPLPFRGGCWCISAPQDQCRDPETCPCKPRPFMGVNMRLAVCNRDHDERGNCFGARRDCFDLRNVAEPYFLLILSRGSEPATPWSQQQKERLTSIFGLYRITDGMYNHFANAVCALVDDMIDPFRAGNAGWVSQVHGILGWYGQSGHHCVEELVRYMSDACRDRLVLESPVLERGRRRRNREDWEGRDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7YUP2</accession>
    <name>C7YUP2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_84991</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050156.1">
        <property type="nucleotide sequence ID" value="XM_003050110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YUP2"/>
    <dbReference type="STRING" id="660122.C7YUP2"/>
    <dbReference type="GeneID" id="9674941"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84991"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84991"/>
    <dbReference type="eggNOG" id="KOG3172">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069177_0_0_1"/>
    <dbReference type="InParanoid" id="C7YUP2"/>
    <dbReference type="OrthoDB" id="6425924at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01721">
        <property type="entry name" value="Sm_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000002">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034099">
        <property type="entry name" value="SmD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="277"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="175"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU44443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="384" mass="43246" checksum="DD3CD3B45BA585A7" modified="2009-10-13" version="1">MNEANEPRRRRRHRIDAPQAQAVTTLKPPAAGAFRGTPTTQWSEWVLHASSSYYYRARYISYDEMLRVIPDGRNSIVSDNVGGHIHYQFMGLNDAAMRNHYTTPTQTPELSTCSGTTPTTAEPSPFQPLPRIHHKERDYISGPPAIEDRKMLMSGALLPPKPDNTYGKALVASKPRISRRKHHQQQQQHHQQQAAVPKKKERKKLEVDKRQMNSNVKLTEHSSRTGSTFPHLPLPQPPSLANFHDIPKLQLQPGPPQLHELERNHTSTATMTSTIGIPIKLLNEAQGHIVTLEITSGQTYRGKLLDAEDNMNVQLKDITVTARDGRVSHLDQVYIRGSHVRFFIVPDMLRNAPMFRSRNVRGRGVGLARGRATVSRARAGGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVN4</accession>
    <name>C7YVN4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_30404</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU43822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049535.1">
        <property type="nucleotide sequence ID" value="XM_003049489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVN4"/>
    <dbReference type="GeneID" id="9677317"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_30404"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_30404"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_2_1_1"/>
    <dbReference type="InParanoid" id="C7YVN4"/>
    <dbReference type="OMA" id="YNPRWPW"/>
    <dbReference type="OrthoDB" id="72788at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF4">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="6">
        <location>
            <begin position="70"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU43822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="455" mass="49738" checksum="FC4349B516AABE4D" modified="2009-10-13" version="1">MAAYLTQRICHPHHGIPVSRPETPAPEKEIKCHQPIYNKASKGVPFFTPEQDPRSGTAIQPQASGKPIPKLFTPLKIRGIEMQNRIWVAPMCQYSAHEGFHTPWHITHYGGMLQRGPGLVMIEATAVQANGRITPEDSGIWLDAHVDTLKKHVDFAHSQNALIGIQLAHAGRKASTVAPWLSSGATASKEVGGWPDDVVSPSDEAFNEHFPTPRAMTIAEIDQFKHDVISGVNRAVGAGFDVIELHFAHGYLVSSFFSPAVNKRTDEYGGTFENRIRLAIELVDATREAIPKGMPLFVRISATEWLDTNPDWKEESWTIDESVKLAKILAERGVDVLDVSSGGNHAQQKIIGGPAYQAPFAKKIKAAVGDKMLVSSVGNIKTGQVAQDVISGGKDEDDTPLDLIAAARMFQKNPGLVWAWADELETDIHVAHQIGWGFGGRAHKDAFGDGKHKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVR1</accession>
    <name>C7YVR1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_89608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU43836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049549.1">
        <property type="nucleotide sequence ID" value="XM_003049503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVR1"/>
    <dbReference type="GeneID" id="9677330"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89608"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89608"/>
    <dbReference type="eggNOG" id="ENOG502QWA6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009942_5_0_1"/>
    <dbReference type="InParanoid" id="C7YVR1"/>
    <dbReference type="OMA" id="HEPQMDE"/>
    <dbReference type="OrthoDB" id="3501663at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF20">
        <property type="entry name" value="AMIDOHYDROLASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase 3" evidence="1">
        <location>
            <begin position="55"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU43836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="538" mass="58789" checksum="227445BB0C7C4E30" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7YW00</accession>
    <name>C7YW00_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_65108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049801.1">
        <property type="nucleotide sequence ID" value="XM_003049755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YW00"/>
    <dbReference type="GeneID" id="9677167"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_65108"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_65108"/>
    <dbReference type="eggNOG" id="ENOG502SS5H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099515_1_0_1"/>
    <dbReference type="InParanoid" id="C7YW00"/>
    <dbReference type="OMA" id="MMFPPVL"/>
    <dbReference type="OrthoDB" id="4868994at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU44088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="140" mass="15251" checksum="3F1C829BBD06B260" modified="2009-10-13" version="1">MASEESGKSKSVLDYLNDWGSNSLPPSLLATLVTALHARPPSLPLFIFTPPLLFSSYLNLSGYPTGSAGLTAAWSGLYALLALRRRQPFRGRFSIRGIVRGTAVGLGTANCIAGGWVYFNGDFEKDAEERVNRNRWGNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7YW92</accession>
    <name>C7YW92_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitotic-spindle organizing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_29629</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for gamma-tubulin complex recruitment to the microtubule organizing center (MTOC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the gamma-tubulin complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MOZART1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU43922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049635.1">
        <property type="nucleotide sequence ID" value="XM_003049589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YW92"/>
    <dbReference type="STRING" id="660122.C7YW92"/>
    <dbReference type="GeneID" id="9677210"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_29629"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_29629"/>
    <dbReference type="eggNOG" id="ENOG502S6UI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160285_2_1_1"/>
    <dbReference type="InParanoid" id="C7YW92"/>
    <dbReference type="OrthoDB" id="48571at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000931">
        <property type="term" value="C:gamma-tubulin ring complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031021">
        <property type="term" value="C:interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033566">
        <property type="term" value="P:gamma-tubulin complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051415">
        <property type="term" value="P:microtubule nucleation by interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022214">
        <property type="entry name" value="MZT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520:SF2">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12554">
        <property type="entry name" value="MOZART1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU43922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="55" mass="6051" checksum="8C88721114FDE1D3" modified="2009-10-13" version="1" fragment="single">MPEPDKHAAAQQAVDILHEISTILNCHLDRRTLSICISMIERGVNPEALAVCLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7YX22</accession>
    <name>C7YX22_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_45515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049222.1">
        <property type="nucleotide sequence ID" value="XM_003049176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YX22"/>
    <dbReference type="STRING" id="660122.C7YX22"/>
    <dbReference type="GeneID" id="9676900"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45515"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45515"/>
    <dbReference type="eggNOG" id="KOG1177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_7_1"/>
    <dbReference type="InParanoid" id="C7YX22"/>
    <dbReference type="OMA" id="PHTAIRI"/>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF6">
        <property type="entry name" value="ACYL COA SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="467"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU43509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="574" mass="63458" checksum="B58596CA58F2D6FC" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXZ6</accession>
    <name>C7YXZ6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_82703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049394.1">
        <property type="nucleotide sequence ID" value="XM_003049348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXZ6"/>
    <dbReference type="GeneID" id="9677027"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82703"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82703"/>
    <dbReference type="eggNOG" id="ENOG502RKR9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_744122_0_0_1"/>
    <dbReference type="InParanoid" id="C7YXZ6"/>
    <dbReference type="OMA" id="CFSAGED"/>
    <dbReference type="OrthoDB" id="3692147at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU43681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="41836" checksum="4DB8A88D99AB2A8F" modified="2009-10-13" version="1">MGAATSCCAPVRPGAQGNDNGIEEHIDEATSPNPGHHGNSDEIDRYLDESTSENRHGTEPPVTPDALVSSALYNAVNSPIYILPDEILLAIIHTLIDDKDSASFFCIRKVSRRFRLLTNDRQFKEVPFCMYSKCNSCYTELNERCSFYRMNSGEVDCQMHWIPRFIGYPPGPKNDIASRLRRDLLCMMCQDGVQERKDAGLPIRCKFAPRDDLDWLDCSSCGLEHPSAVFSSLQRQKINDRVCVAKEGYIRLCQHEVIRWDDIQPWAGPGIRYHHEVIKVCKHASHSVACCEQASWPKATVTAHENGITTLSLSWNPHSGPDLNPGRLGPQRHSATEVRAVAQRFRADAARFIVPEQRSGHLPEMECFTKGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7YY36</accession>
    <name>C7YY36_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_101106</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049155.1">
        <property type="nucleotide sequence ID" value="XM_003049109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YY36"/>
    <dbReference type="STRING" id="660122.C7YY36"/>
    <dbReference type="GeneID" id="9666545"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101106"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101106"/>
    <dbReference type="eggNOG" id="ENOG502RZ8N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015092_1_1_1"/>
    <dbReference type="InParanoid" id="C7YY36"/>
    <dbReference type="OMA" id="ICTVFDW"/>
    <dbReference type="OrthoDB" id="5242705at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="684"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU43442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="757" mass="82926" checksum="6BF35386C4DAABD1" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYD7</accession>
    <name>C7YYD7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_46494</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048882.1">
        <property type="nucleotide sequence ID" value="XM_003048836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYD7"/>
    <dbReference type="STRING" id="660122.C7YYD7"/>
    <dbReference type="GeneID" id="9665474"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_46494"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_46494"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_6_1_1"/>
    <dbReference type="InParanoid" id="C7YYD7"/>
    <dbReference type="OMA" id="DPRYCAD"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.450.10">
        <property type="entry name" value="Glucose Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027424">
        <property type="entry name" value="Glucose_Oxidase_domain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF115">
        <property type="entry name" value="DEHYDROGENASE XPTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002986666" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="8">
        <location>
            <begin position="22"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="9">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="475"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="518"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU43169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="534" mass="58349" checksum="0014E81318CB7525" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYG4</accession>
    <name>C7YYG4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aromatic amino acid beta-eliminating lyase/threonine aldolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_95452</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048714.1">
        <property type="nucleotide sequence ID" value="XM_003048668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYG4"/>
    <dbReference type="FunCoup" id="C7YYG4">
        <property type="interactions" value="998"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YYG4"/>
    <dbReference type="GeneID" id="9665819"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95452"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95452"/>
    <dbReference type="eggNOG" id="KOG1368">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029381_1_0_1"/>
    <dbReference type="InParanoid" id="C7YYG4"/>
    <dbReference type="OMA" id="VQTNIVI"/>
    <dbReference type="OrthoDB" id="10261951at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008732">
        <property type="term" value="F:L-allo-threonine aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06502">
        <property type="entry name" value="TA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000030">
        <property type="entry name" value="Low-specificity L-threonine aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041359">
        <property type="entry name" value="GntG_guanitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="L-THREONINE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097">
        <property type="entry name" value="L-THREONINE ALDOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic amino acid beta-eliminating lyase/threonine aldolase" evidence="7">
        <location>
            <begin position="51"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="374"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU43001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="413" mass="44341" checksum="F0AD75AC75DD0FFA" modified="2009-10-13" version="1">MRPSSRLVSSCLSPSPHRFFASSSVAMGDSFATSEKTHNAWIGAKGPAAFDLRSDVVTTPTPAMLQAIQSCSLLDDVFQEDPATNDLEAYIAGRTGKEAGLFVLSGTMGNQLALRSLLTQPPHSVICDYRAHIFTSEAGGTSALTGAQIQPIVPKNGKYMTLEEIMANAVLDDDVHGCPTRVISLENTLHGMVIPLSEVKRISEFAKEHGIKLHLDGARLWEAVVSGAGSLPEYCSYFDTVTLCLSKGLGAPVGSVLVGSKATIKHARWTRKSIGGGLRQSGVVTSAGRVAVEQTFGASPNGEDGPLKASHETARKVDALWASLGGKVEEPTETNMVWLDLKAVGCSEKRFIEIGKEEGLKFMCNRLVTHYQVAQNEEEVLKRLRAVFDKVLAEKEDLSSKPQVGKGSVYVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYT4</accession>
    <name>C7YYT4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_83798</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048963.1">
        <property type="nucleotide sequence ID" value="XM_003048917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYT4"/>
    <dbReference type="FunCoup" id="C7YYT4">
        <property type="interactions" value="382"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YYT4"/>
    <dbReference type="GeneID" id="9665540"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83798"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83798"/>
    <dbReference type="eggNOG" id="KOG1965">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005912_5_2_1"/>
    <dbReference type="InParanoid" id="C7YYT4"/>
    <dbReference type="OMA" id="FTYVRRF"/>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF187">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="356"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="47"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="513"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="537"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="563"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU43250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="646" mass="70425" checksum="74FF14E88854B24B" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYV9</accession>
    <name>C7YYV9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EXPERA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_46522</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PrpF family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048975.1">
        <property type="nucleotide sequence ID" value="XM_003048929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYV9"/>
    <dbReference type="STRING" id="660122.C7YYV9"/>
    <dbReference type="GeneID" id="9665628"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_46522"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_46522"/>
    <dbReference type="eggNOG" id="KOG4826">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_357903_0_0_1"/>
    <dbReference type="InParanoid" id="C7YYV9"/>
    <dbReference type="OrthoDB" id="10267539at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007400">
        <property type="entry name" value="PrpF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709">
        <property type="entry name" value="ACONITATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709:SF2">
        <property type="entry name" value="DUF453 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G00360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13772">
        <property type="entry name" value="AIG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04303">
        <property type="entry name" value="PrpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="704"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="743"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="9">
        <location>
            <begin position="596"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU43262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="783" mass="85775" checksum="23E5C10B1EC01E8E" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZ03</accession>
    <name>C7YZ03_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_46756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048805.1">
        <property type="nucleotide sequence ID" value="XM_003048759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZ03"/>
    <dbReference type="GeneID" id="9666067"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_46756"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_46756"/>
    <dbReference type="eggNOG" id="ENOG502SP43">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090736_0_0_1"/>
    <dbReference type="InParanoid" id="C7YZ03"/>
    <dbReference type="OMA" id="PHFGTLC"/>
    <dbReference type="OrthoDB" id="3890746at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU43092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="233" mass="24925" checksum="9D6D043163ACABDB" modified="2009-10-13" version="1">MDPTLSHISTGSKTEISAASNFDADMDDAKFESKSRMFRLTDSARLGLTVLGLAAGITILGVSADSIAVYNATHVPGDYLLPLWPANFDLRPTVALVVCSVLMMVANAISLVSSKVPTMRNKTGVEMTLAFGPPIVALIAAIISMSFFYAVNASTEVDTLQSWSCRWENIAMTTQPHFDTLCKQSRAGVALSVLLVPVEVIILGLAAYQFMLRRQLDLTARGPGRKAGSPALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZB0</accession>
    <name>C7YZB0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_47393</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048485.1">
        <property type="nucleotide sequence ID" value="XM_003048439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZB0"/>
    <dbReference type="STRING" id="660122.C7YZB0"/>
    <dbReference type="GeneID" id="9667736"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_47393"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_47393"/>
    <dbReference type="eggNOG" id="ENOG502SDK4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019535_0_0_1"/>
    <dbReference type="InParanoid" id="C7YZB0"/>
    <dbReference type="OMA" id="KEYIWEW"/>
    <dbReference type="OrthoDB" id="166746at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21552">
        <property type="entry name" value="VEFS-box_ctSUZ12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019135">
        <property type="entry name" value="Polycomb_protein_VEFS-Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597:SF0">
        <property type="entry name" value="POLYCOMB PROTEIN SUZ12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09733">
        <property type="entry name" value="VEFS-Box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="8">
        <location>
            <begin position="733"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="33"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="353"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="517"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="702"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="548"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU42772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="790" mass="87566" checksum="9D46974B6105D6AF" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZX2</accession>
    <name>C7YZX2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="10">PPIase</shortName>
            <ecNumber evidence="10">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_95831</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048399.1">
        <property type="nucleotide sequence ID" value="XM_003048353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZX2"/>
    <dbReference type="STRING" id="660122.C7YZX2"/>
    <dbReference type="GeneID" id="9667476"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95831"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95831"/>
    <dbReference type="eggNOG" id="KOG0415">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018791_2_1_1"/>
    <dbReference type="InParanoid" id="C7YZX2"/>
    <dbReference type="OMA" id="APKCCEN"/>
    <dbReference type="OrthoDB" id="2083at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01921">
        <property type="entry name" value="cyclophilin_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12235">
        <property type="entry name" value="RRM_PPIL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000015">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000287">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035542">
        <property type="entry name" value="CRIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035538">
        <property type="entry name" value="Cyclophilin_PPIL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843:SF1">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="12">
        <location>
            <begin position="6"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="251"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="333"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="178"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="385"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="424"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU42686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="483" mass="55503" checksum="089006636A4218D0" modified="2009-10-13" version="1">MSVLLETSVGDIVIDLLVDHAPKLCENFLKLCKLKYYNFSPVHSVQKNFSFQTGDPLGPLSKDSDGGSSIWGHLSGDSSKRTFPAFFHPKLKHLERGTVSMATAPLQSDPDTRVAASQFIITLGEDTDFLDGKAAIFGKVVEGFDALEKINEAIVDDKGYPLIDIRIKHTVILDDPYPDPPGLREPSSSPPPTDQQLKTVRIADEAALHADDNVDEEELEKRRRNREAQAQALTLEMMGDLPFAEVKPPENVLFVCKLNPVTGDEDLELIFGRFGKILSCEVIRDQKTGDSLQYAFIEYEDKASCEAAYFKMQDVLIDDRRIHVDFSQSVSKLSDSWRNDTNKKRRANAGRGGWGGVRELEKRRQYREERERSTEGDYGMVYGEEEMKGKLERNGPGRQKDDGPPPKPRDAEGPGRRSRSRSPRPRDRSRDRYRKPRDDRRGDRRDWDRRDRDRNRGRDRDRRDRDRDRDRYGRDDYDRRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z066</accession>
    <name>C7Z066_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_63211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048445.1">
        <property type="nucleotide sequence ID" value="XM_003048399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z066"/>
    <dbReference type="GeneID" id="9667522"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_63211"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_63211"/>
    <dbReference type="eggNOG" id="ENOG502SPD0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117282_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z066"/>
    <dbReference type="OMA" id="PYECRHD"/>
    <dbReference type="OrthoDB" id="5352317at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988830" evidence="1">
        <location>
            <begin position="19"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="148" mass="15461" checksum="B711E1D68679F3FA" modified="2009-10-13" version="1">MKFSAAVLAIVAATGVSAAPAASDSVSMMAATPQWTIRDAKRYCRADDSICNWKFGIDTGNGKVVECRHDVKGPKASQKAAAGPSTCGDFTVTSGWSGQFGAGNGFTTLSVVSKSKRQIIWPAYTDKQLAGAKIVKPDQSYAPASLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z118</accession>
    <name>C7Z118_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_39968</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048003.1">
        <property type="nucleotide sequence ID" value="XM_003047957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z118"/>
    <dbReference type="FunCoup" id="C7Z118">
        <property type="interactions" value="509"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z118"/>
    <dbReference type="GeneID" id="9667374"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_39968"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_39968"/>
    <dbReference type="eggNOG" id="KOG0554">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_0_1"/>
    <dbReference type="InParanoid" id="C7Z118"/>
    <dbReference type="OMA" id="PEMAFYD"/>
    <dbReference type="OrthoDB" id="43906at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070145">
        <property type="term" value="P:mitochondrial asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04318">
        <property type="entry name" value="EcAsnRS_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003037">
        <property type="entry name" value="PRK03932.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF34">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="176"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU42290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="526" mass="59300" checksum="5C13DE79E76D6ECF" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z353</accession>
    <name>C7Z353_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">5-oxoprolinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_54297</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047483.1">
        <property type="nucleotide sequence ID" value="XM_003047437.1"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z353"/>
    <dbReference type="GeneID" id="9675915"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_54297"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_54297"/>
    <dbReference type="eggNOG" id="KOG1939">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002157_0_1_1"/>
    <dbReference type="InParanoid" id="C7Z353"/>
    <dbReference type="OMA" id="GTGPQMW"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="5">
        <location>
            <begin position="5"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="3">
        <location>
            <begin position="239"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="6">
        <location>
            <begin position="541"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="4">
        <location>
            <begin position="743"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1262"/>
            <end position="1289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU41770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1289" mass="139822" checksum="03948C833F8C9FD8" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z3D6</accession>
    <name>C7Z3D6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_87912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047530.1">
        <property type="nucleotide sequence ID" value="XM_003047484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z3D6"/>
    <dbReference type="GeneID" id="9676341"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87912"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87912"/>
    <dbReference type="HOGENOM" id="CLU_1395779_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z3D6"/>
    <dbReference type="OMA" id="IDDICPF"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="45"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU41817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="214" mass="24390" checksum="451E6DBA3581BD78" modified="2009-10-13" version="1">MDNLVQRIVDTYAECAPTYDEEVTQFPYYQTLRKLIFTFDWAGSVVDLGCGTGLLGQLLNEKGEPFTIMGVDLSPAMTASPSISKYYETPITIGTVQAAITQPLKVNHVACFGTLTYLNDHEFLTFLERALEVAQRSITFDMEDVSQEYREKMAEDKTILPCYNHTKAWKAWKESKLPAGWRVVYDEYGLQYHDNHETGCDINDTMVRLEKAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z3Y1</accession>
    <name>C7Z3Y1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 12">Vacuolar protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_95282</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 12">Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Vacuole membrane</location>
            <topology evidence="1 12">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the beta-catenin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046934.1">
        <property type="nucleotide sequence ID" value="XM_003046888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z3Y1"/>
    <dbReference type="FunCoup" id="C7Z3Y1">
        <property type="interactions" value="133"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z3Y1"/>
    <dbReference type="GeneID" id="9675581"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95282"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95282"/>
    <dbReference type="eggNOG" id="KOG4224">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021483_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z3Y1"/>
    <dbReference type="OMA" id="VWDKPDG"/>
    <dbReference type="OrthoDB" id="7537227at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071563">
        <property type="term" value="C:Myo2p-Vac17p-Vac8p transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051656">
        <property type="term" value="P:establishment of organelle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061724">
        <property type="term" value="P:lipophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071562">
        <property type="term" value="P:nucleus-vacuole junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903044">
        <property type="term" value="P:protein localization to membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031503">
        <property type="term" value="P:protein-containing complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000243">
        <property type="entry name" value="Putative Vacuolar protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000095">
        <property type="entry name" value="Vacuolar protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045156">
        <property type="entry name" value="Vac8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47249">
        <property type="entry name" value="VACUOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47249:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0926">Vacuole</keyword>
    <feature type="repeat" description="ARM" evidence="11">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="11">
        <location>
            <begin position="130"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="11">
        <location>
            <begin position="171"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="11">
        <location>
            <begin position="212"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="11">
        <location>
            <begin position="255"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="11">
        <location>
            <begin position="296"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="11">
        <location>
            <begin position="337"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU369097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU41221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="562" mass="61225" checksum="3451F66C5B6BEDED" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z422</accession>
    <name>C7Z422_FUSV7</name>
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        <recommendedName>
            <fullName evidence="4">Increased recombination centers protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_95305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EEU41241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z422"/>
    <dbReference type="STRING" id="660122.C7Z422"/>
    <dbReference type="GeneID" id="9675290"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95305"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95305"/>
    <dbReference type="eggNOG" id="ENOG502RTVH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031716_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z422"/>
    <dbReference type="OMA" id="EALMMRM"/>
    <dbReference type="OrthoDB" id="10261384at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034627">
        <property type="entry name" value="Irc6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28043">
        <property type="entry name" value="INCREASED RECOMBINATION CENTERS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28043:SF1">
        <property type="entry name" value="INCREASED RECOMBINATION CENTERS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10199">
        <property type="entry name" value="Adaptin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU41241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="35383" checksum="0BBA13B35D6A7444" modified="2009-10-13" version="1">MAEAEMSSASRRILAVALEGETTILSSVVKDLTGSSPSTPADPSLSLAGTTHSLHLKTPYYTTTVPIWLDLISSPSEWSSSFLSPEAIEVLAVLGGVVVIFTASPVSAEKEHPGRSLIEHVGKVLKQGLGGWDWDGVGLAVGVGGDGSEEDWDEICAEAGLEFVSVGGKGDTGRNEFGEKTGIARVKEALEANDWSQLEVPLSDSDFGDFETSSAKAHDDDHDDDELDPQKMGFGFDRSDFEGLRRAIWEAGQDNEEPSESSKEAGKKDKSSEEAATRGGFEDLDDDDIAKVEKMMRKLQAVREAGEGMGEEQRKRMAARAVEEVMKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z597</accession>
    <name>C7Z597_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_32901</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046197.1">
        <property type="nucleotide sequence ID" value="XM_003046151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z597"/>
    <dbReference type="FunCoup" id="C7Z597">
        <property type="interactions" value="321"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z597"/>
    <dbReference type="GeneID" id="9678303"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_32901"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_32901"/>
    <dbReference type="eggNOG" id="ENOG502QQXX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006632_1_2_1"/>
    <dbReference type="InParanoid" id="C7Z597"/>
    <dbReference type="OMA" id="HIFAFNW"/>
    <dbReference type="OrthoDB" id="2264294at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="236"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="667"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="688"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU40484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="705" mass="78277" checksum="8D2EDD3382CBAA40" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z5A8</accession>
    <name>C7Z5A8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_91304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU41065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003046732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z5A8"/>
    <dbReference type="GeneID" id="9678310"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_91304"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_91304"/>
    <dbReference type="eggNOG" id="ENOG502QURU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002370_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z5A8"/>
    <dbReference type="OMA" id="KYMGVPR"/>
    <dbReference type="OrthoDB" id="5367052at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="557"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="633"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1087"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="770"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="581"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="659"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="697"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="708"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1099"/>
            <end position="1117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU41065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1169" mass="128681" checksum="67D13FB31F57BD57" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z5D7</accession>
    <name>C7Z5D7_FUSV7</name>
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        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_76831</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU41081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003046748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z5D7"/>
    <dbReference type="FunCoup" id="C7Z5D7">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="GeneID" id="9678323"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76831"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76831"/>
    <dbReference type="eggNOG" id="KOG2262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004965_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z5D7"/>
    <dbReference type="OMA" id="SYCVWPQ"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="375"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="521"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="631"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="665"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="697"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="742"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="776"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU41081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="842" mass="94544" checksum="F4A6C1BCE151E469" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z5E1</accession>
    <name>C7Z5E1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="12">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Transfer RNA methyltransferase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TRM8</name>
        <name evidence="19" type="ORF">NECHADRAFT_66805</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
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            <dbReference type="ChEBI" id="CHEBI:59789"/>
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            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="11 12">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Forms a complex with TRM82.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="12"/>
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        <property type="protein sequence ID" value="EEU40505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_003046218.1">
        <property type="nucleotide sequence ID" value="XM_003046172.1"/>
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    <dbReference type="FunCoup" id="C7Z5E1">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z5E1"/>
    <dbReference type="GeneID" id="9678324"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_66805"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_66805"/>
    <dbReference type="eggNOG" id="KOG2101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3115">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002131_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z5E1"/>
    <dbReference type="OMA" id="AMYVVEV"/>
    <dbReference type="OrthoDB" id="120967at2759"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106143">
        <property type="term" value="C:tRNA (m7G46) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06876">
        <property type="entry name" value="PX_MDM1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000060">
        <property type="entry name" value="tRNA (guanine-N(7)-)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03055">
        <property type="entry name" value="tRNA_methyltr_TrmB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025763">
        <property type="entry name" value="Trm8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00091">
        <property type="entry name" value="tRNA (guanosine(46)-N7)-methyltransferase TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 12" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4 12" id="KW-0820">tRNA-binding</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="18">
        <location>
            <begin position="383"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="16">
        <location>
            <begin position="698"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="17">
        <location>
            <begin position="1160"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="586"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="673"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="845"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1001"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1053"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1117"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="589"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="858"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="882"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1062"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="113"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="147"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="245"/>
            <end position="247"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEU40505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1492" mass="167469" checksum="43C223298EC1D7B1" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z5P3</accession>
    <name>C7Z5P3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_33775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EEU40561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003046228.1"/>
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    <dbReference type="STRING" id="660122.C7Z5P3"/>
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    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_33775"/>
    <dbReference type="eggNOG" id="ENOG502QUV4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_4_2_1"/>
    <dbReference type="InParanoid" id="C7Z5P3"/>
    <dbReference type="OMA" id="WSMGPFF"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002986814" description="FAD-binding PCMH-type domain-containing protein" evidence="3">
        <location>
            <begin position="30"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="183"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU40561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="651" mass="71226" checksum="27E40D22EC7FF592" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-11-30" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z638</accession>
    <name>MTNA_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="1">M1Pi</shortName>
            <shortName evidence="1">MTR-1-P isomerase</shortName>
            <ecNumber evidence="1">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">MRI1</name>
        <name type="ORF">NECHADRAFT_57836</name>
    </gene>
    <organism>
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-(methylsulfanyl)-alpha-D-ribose 1-phosphate = 5-(methylsulfanyl)-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="1"/>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045774.1">
        <property type="nucleotide sequence ID" value="XM_003045728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z638"/>
    <dbReference type="SMR" id="C7Z638"/>
    <dbReference type="FunCoup" id="C7Z638">
        <property type="interactions" value="749"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z638"/>
    <dbReference type="EnsemblFungi" id="NechaT57836">
        <property type="protein sequence ID" value="NechaP57836"/>
        <property type="gene ID" value="NechaG57836"/>
    </dbReference>
    <dbReference type="GeneID" id="9678447"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_57836"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_57836"/>
    <dbReference type="eggNOG" id="KOG1468">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_1_3_1"/>
    <dbReference type="InParanoid" id="C7Z638"/>
    <dbReference type="OMA" id="CETRPLN"/>
    <dbReference type="OrthoDB" id="2461at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.420:FF:000003">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000003">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="entry name" value="translation initiation factor eif-2b, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004326">
        <property type="entry name" value="PRK05720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF1">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0486">Methionine biosynthesis</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000402034" description="Methylthioribose-1-phosphate isomerase">
        <location>
            <begin position="1"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03119"/>
        </source>
    </evidence>
    <sequence length="388" mass="42201" checksum="CD94C17ADB19A2BE" modified="2009-10-13" version="1">MSTLQAVKYIRGKLEVLDQLRLPHEFHYDEVSNRTEAFDSIYTMRVRGAPAIAIVAALGLAVELHNGSCTASSAEETIGQIEEALDYLKESRPTAVDLTNAINQLKARIREVGSTATKEAIISAFIEEAEKIFEKDLKTNLSIGDFGAEWLRAQVGASPEQQISVLTHCNTGSLATSGHGTALGIIRTLQAKKLLHHAFCTETRPYNQGSRLTAFELVFEGIPSTLITDSMAASLFRTRKQEKNIAAVIVGADRVVRNGDTANKIGTYQLAVLAKHHGVKFIVAAPTTSIDLETETGDGIKIEERKKEELTQVTGAVIKPDGTVDESSKVRVATADQRINVWNPAFDVTPAEFIDAVVTEKGAIEKGPDGKFDFSQILPERWAKITGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6K7</accession>
    <name>C7Z6K7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_7029</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046423.1">
        <property type="nucleotide sequence ID" value="XM_003046377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6K7"/>
    <dbReference type="GeneID" id="9668696"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_7029"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_7029"/>
    <dbReference type="eggNOG" id="ENOG502SIGA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_863374_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z6K7"/>
    <dbReference type="OrthoDB" id="2283488at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR ASQA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="29"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU40710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="293" mass="32965" checksum="C7AC508224697A89" modified="2009-10-13" version="1" fragment="single">ELESPSITTLQCHLFSVVYLCCASFQNMAHSTLAAAMSIAQTLGLHLEPPASMPRAEKELRKRLWWATFINDSKTSMKVGRPISMQRSQITVSPISDDEEAASFFDSSLGSYDGVTWLTYAAQNQKLIIVSTDIHNAFYERCSEILGQSRHSTPYKNSKDLESCAKFITSQLPALQAWADQVPPGLRLQRRDSGAPFSADRAPVLIDSCAPLWLQRHRICLELIYHTLQSNLHRPFINFAPPPGTYTPTAERHAATCANHAAAYTHILHQTLQETDIMNGWQEFFIWQWNATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z744</accession>
    <name>C7Z744_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_76304</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046520.1">
        <property type="nucleotide sequence ID" value="XM_003046474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z744"/>
    <dbReference type="FunCoup" id="C7Z744">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z744"/>
    <dbReference type="GeneID" id="9668861"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76304"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76304"/>
    <dbReference type="eggNOG" id="KOG0191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021868_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z744"/>
    <dbReference type="OMA" id="IFVYFYD"/>
    <dbReference type="OrthoDB" id="72053at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052250">
        <property type="entry name" value="PDI_TMX3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426:SF1">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988549" description="Thioredoxin domain-containing protein" evidence="7">
        <location>
            <begin position="19"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="704"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="16"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="286"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="168"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="181"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="242"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU40807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="756" mass="85662" checksum="44688661E81F90E3" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7L6</accession>
    <name>C7Z7L6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_33256</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046609.1">
        <property type="nucleotide sequence ID" value="XM_003046563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7L6"/>
    <dbReference type="FunCoup" id="C7Z7L6">
        <property type="interactions" value="1223"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z7L6"/>
    <dbReference type="GeneID" id="9668394"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_33256"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_33256"/>
    <dbReference type="eggNOG" id="KOG2081">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005996_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z7L6"/>
    <dbReference type="OMA" id="LECITSW"/>
    <dbReference type="OrthoDB" id="435593at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000266">
        <property type="entry name" value="mRNA transport regulator MTR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057941">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057942">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058537">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF53">
        <property type="entry name" value="MRNA TRANSPORT REGULATOR MTR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24138">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24140">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24139">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="3">
        <location>
            <begin position="33"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU40896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="971" mass="109115" checksum="6F61CA5CFAB4DD2D" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z856</accession>
    <name>C7Z856_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxypeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_39178</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045652.1">
        <property type="nucleotide sequence ID" value="XM_003045606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z856"/>
    <dbReference type="MEROPS" id="S10.016"/>
    <dbReference type="GeneID" id="9672552"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_39178"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_39178"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008523_10_3_1"/>
    <dbReference type="InParanoid" id="C7Z856"/>
    <dbReference type="OMA" id="PCSVNAD"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF189">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002986870" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU39939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="634" mass="69931" checksum="E106EC4C9B75D69C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8A7</accession>
    <name>C7Z8A7_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_79722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045549.1">
        <property type="nucleotide sequence ID" value="XM_003045503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8A7"/>
    <dbReference type="STRING" id="660122.C7Z8A7"/>
    <dbReference type="GeneID" id="9672578"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79722"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79722"/>
    <dbReference type="eggNOG" id="ENOG502SJK3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013814_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z8A7"/>
    <dbReference type="OMA" id="FCWALAG"/>
    <dbReference type="OrthoDB" id="5419219at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="584"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="618"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU39836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="800" mass="90754" checksum="4804280C5828509C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8I6</accession>
    <name>C7Z8I6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_81483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045083.1">
        <property type="nucleotide sequence ID" value="XM_003045037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8I6"/>
    <dbReference type="STRING" id="660122.C7Z8I6"/>
    <dbReference type="GeneID" id="9673510"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_81483"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_81483"/>
    <dbReference type="eggNOG" id="ENOG502QW00">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063392_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z8I6"/>
    <dbReference type="OMA" id="DYHLGFL"/>
    <dbReference type="OrthoDB" id="187894at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048244">
        <property type="term" value="F:phytanoyl-CoA dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001561">
        <property type="term" value="P:fatty acid alpha-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047128">
        <property type="entry name" value="PhyH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21308">
        <property type="entry name" value="PHYTANOYL-COA ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21308:SF8">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G09620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU39370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="44576" checksum="2FA473F1DBCFECB7" modified="2009-10-13" version="1">MASNGTTHKNGVDGILSEQGQARLFKLSPPPSLDAFKAICEQRATKEEYPLAADIKENIPIYNLAEYSTLTEEQKLALQDEWYRVLLHGPGVLVTAGLYKDHGVIDKATATYARIIQKESKGTKVSGDHFAGAGKNDRIWNSFSKHGLEDPASFLSYYSNPYLDLIFGSWLGPAYRVTAQVNNVRPGGQPQVSHRDYHLGFMSTERCGGYPRAMQVASQCLTLQGAVAHVDVPLESGPTRLLPFSQAFSAGYMAYRLPEFNEFFLEKYVALPLQKGDGLFFNPALFHAAGENKSSDINRLVNLLQISSAFGKPMETIDALPLVERTWDDLTALYKAKGLSDEVKMFVSAVGEGYPFPTNLDNNPPKNESMAPDSEQDIILGALVKGKSKAQVLTDLEAFRTKIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z995</accession>
    <name>C7Z995_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_94378</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044731.1">
        <property type="nucleotide sequence ID" value="XM_003044685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z995"/>
    <dbReference type="GeneID" id="9673231"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94378"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94378"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_3_1"/>
    <dbReference type="InParanoid" id="C7Z995"/>
    <dbReference type="OMA" id="LFFVHHR"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF50">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="49"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU39018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="529" mass="58166" checksum="ADAE6E91AE03D455" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9R9</accession>
    <name>C7Z9R9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_43219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045262.1">
        <property type="nucleotide sequence ID" value="XM_003045216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9R9"/>
    <dbReference type="FunCoup" id="C7Z9R9">
        <property type="interactions" value="179"/>
    </dbReference>
    <dbReference type="GeneID" id="9672044"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_43219"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_43219"/>
    <dbReference type="eggNOG" id="KOG4754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039184_0_1_1"/>
    <dbReference type="InParanoid" id="C7Z9R9"/>
    <dbReference type="OMA" id="HGLGVHN"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="34265" checksum="25E94328CE282488" modified="2009-10-13" version="1">MTTWTFKAEPGIFVEIADIAHQYPQGKVTTQPSLGLIPGQKYPSDDPNASDQRDWARLTAYVRWLNETCPENVCYKLLYLTRHGTGVHNKVHTEVGSEAWNSRVSFQDGNDKETWFDAFLTDVGIQQAAELNTFWTNLINIDGAPIPEIIYTSPLARCLQTTSLVFSSLMSSHSAEFQPMVKELLRERITMHTCDFRRSRTWIAENYPNYKIEEGFTEDDGFRKRSGPETKGEHIERKQRALEEIFEEARDNQFISLTVHSYAIRAIQAAVGAGVCRTREGTSLALLVRGERREQVNGAAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9S1</accession>
    <name>C7Z9S1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RTA1 like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_44031</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045263.1">
        <property type="nucleotide sequence ID" value="XM_003045217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9S1"/>
    <dbReference type="FunCoup" id="C7Z9S1">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="GeneID" id="9672045"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_44031"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_44031"/>
    <dbReference type="eggNOG" id="ENOG502QURG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033465_3_1_1"/>
    <dbReference type="InParanoid" id="C7Z9S1"/>
    <dbReference type="OMA" id="IVRRTWM"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF35">
        <property type="entry name" value="RTA1 DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU39550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="31378" checksum="84E92B7731ACF3B2" modified="2009-10-13" version="1">MANDYYKYDPSVAAAVIFIVAFGISGFYHAYQVARLRSWYFIPFVIGCAVEAIGYGGRAINASEDSEQWSKGPYIIQALLLLLGPPFYAASIYMVLGRLIRLLEADKFSMVRLKWLTKIFLFGDIVSILAQGMGGGMLAGADTKSARDRGQTVIIVGLFVQLIFFGFFGIVAIVFHRRINNEPTSASLKIHSPWQKLLIALYVSSALIMVRSIFRVIEYVMGEDGELMAKEAYIYIFDATLMLIVSVIFNVFHPSAIINKQSMQRLYNTDSENQLQSLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9Y2</accession>
    <name>C7Z9Y2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_42807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045295.1">
        <property type="nucleotide sequence ID" value="XM_003045249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9Y2"/>
    <dbReference type="STRING" id="660122.C7Z9Y2"/>
    <dbReference type="GeneID" id="9672074"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_42807"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_42807"/>
    <dbReference type="eggNOG" id="ENOG502QPN7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019746_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z9Y2"/>
    <dbReference type="OMA" id="VVPWMMF"/>
    <dbReference type="OrthoDB" id="2019015at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF20">
        <property type="entry name" value="FLAVIN-CONTAINING AMINE OXIDASEDEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="58898" checksum="2ABCD7EBF07B1B90" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZA29</accession>
    <name>C7ZA29_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_43033</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase G subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045319.1">
        <property type="nucleotide sequence ID" value="XM_003045273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZA29"/>
    <dbReference type="FunCoup" id="C7ZA29">
        <property type="interactions" value="304"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZA29"/>
    <dbReference type="GeneID" id="9672097"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_43033"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_43033"/>
    <dbReference type="eggNOG" id="KOG1772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125101_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZA29"/>
    <dbReference type="OMA" id="ARKYRQD"/>
    <dbReference type="OrthoDB" id="250802at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2950:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01147">
        <property type="entry name" value="V_ATP_synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713:SF11">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU39606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="111" mass="12395" checksum="AD23C945555E40DB" modified="2009-10-13" version="1" fragment="single">SAQNSAGIQTLLDAEREASKIVQKVRTKRIREARDEAKQEIADYKNNKEDEYKKFEAEHSKGNQQAEDEANKEADAQIKTIQEAGKKGQAQVVKNLLNAVFEVQPVAPTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAG5</accession>
    <name>C7ZAG5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_43331</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044983.1">
        <property type="nucleotide sequence ID" value="XM_003044937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAG5"/>
    <dbReference type="STRING" id="660122.C7ZAG5"/>
    <dbReference type="GeneID" id="9672165"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_43331"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_43331"/>
    <dbReference type="eggNOG" id="KOG4245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039329_5_2_1"/>
    <dbReference type="InParanoid" id="C7ZAG5"/>
    <dbReference type="OMA" id="GHMGERI"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF31">
        <property type="entry name" value="AMIDOHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G05840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="38"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU39270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="341" mass="38152" checksum="2A91D0E72A57B1A3" modified="2009-10-13" version="1">MAKGTVAIEEAVVNADDLEWLSQTANIYAPGQTGQTQHHALTRKLADIHDERLKAMDANGVDYMLLSLTSPGSQGESDPVKASSLAVRSNDWLAKQVAENPKRFGALAALSMHDADEAAAELRRAVKELGMFGALINDFQSAGPDSSVKKYYDTPEYLPFWKAVEELDVPVYLHPRYPIDSELHSDGKFGPRKQILGAAVQFHLDLSFHIYALCSSGIFDQFPRVQVVIGHMGEGIPFNLWRADHWYNKPVKKATRPSKHDYSYYLKHNVSITTSGNFSTDVMKFCVAQLGVERCMFSIDYPYDTIEEAQDWWKGAELPEDQKQAVGRSNAIKLFKLPLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAL0</accession>
    <name>C7ZAL0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_94726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045408.1">
        <property type="nucleotide sequence ID" value="XM_003045362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAL0"/>
    <dbReference type="GeneID" id="9672189"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94726"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94726"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120074_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZAL0"/>
    <dbReference type="OMA" id="ARSHILC"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF11">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="140" mass="16367" checksum="F2B414F304279181" modified="2009-10-13" version="1">MPNYFIFNGPNYLVGYGSLLSIMDWIADYIMRWIKKISTGDIKSVTVDVGAIADYNTYTHEFLKRTVWISGCRSWYKNNKVDGKVTAMYAGSIIHYKEILESFRTEDFNFEYNSRNRFRFMGNGLTVLEEKGENLGFYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAN3</accession>
    <name>C7ZAN3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_82156</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045017.1">
        <property type="nucleotide sequence ID" value="XM_003044971.1"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZAN3"/>
    <dbReference type="GeneID" id="9672199"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82156"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82156"/>
    <dbReference type="eggNOG" id="KOG0594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_242740_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZAN3"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359:SF1">
        <property type="entry name" value="INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE EPSILON SUBUNIT HOMOLOG 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1253"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1283"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="298"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="862"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="981"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1368"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1457"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="862"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1510"/>
            <end position="1538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU39304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1643" mass="184515" checksum="95166D3F6B988D08" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAW1</accession>
    <name>C7ZAW1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_106275</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 77 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044502.1">
        <property type="nucleotide sequence ID" value="XM_003044456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAW1"/>
    <dbReference type="GeneID" id="9670696"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_106275"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_106275"/>
    <dbReference type="eggNOG" id="ENOG502S9ID">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_554363_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZAW1"/>
    <dbReference type="OMA" id="WDDCAND"/>
    <dbReference type="OrthoDB" id="3763672at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005069">
        <property type="entry name" value="Nucl-diP-sugar_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF3">
        <property type="entry name" value="NUCLEOTIDE-DIPHOSPHO-SUGAR TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03407">
        <property type="entry name" value="Nucleotid_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotide-diphospho-sugar transferase" evidence="5">
        <location>
            <begin position="203"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU38789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="406" mass="46283" checksum="83FF1A3CE430A84F" modified="2009-10-13" version="1">MMGAVRSNRVALLVAAVFFTFFMGLAHFHLNATQSRPATAISDSDEYIPDVDHAVASPDNAPKEPEIEVVEEVVEVEVEETPTPTPTPTAAESHVLRPQDFVIPSVKPTTPQFADYGAWGWKLPHPDPIWKESLGERLCIVDLESRPFDKPGQIWDPQGMSWSRAKDVHGPSGGTLNHWVYSQIHGYKYYYVKINTYKDRRDSWKKPSVLSKILKNHDVCIFIDSDALFNHLDLPLEWLMNYWSISPHNNSLALAVDPDVQHNHDRFGKLFLNTGFMIMQNNNKTYDIFRDWDDCPNEGSKYPGCTEFRHRKGWQPTDQGGFGTFVRYDYPNDIKELPCTEANGFPEANQGCMGKFIKHVWLGKEDRLKIVVGNVFPGTLLETFHKQFLAAKNTFFTTEDALMSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAZ8</accession>
    <name>C7ZAZ8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_83077</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044522.1">
        <property type="nucleotide sequence ID" value="XM_003044476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAZ8"/>
    <dbReference type="STRING" id="660122.C7ZAZ8"/>
    <dbReference type="GeneID" id="9670817"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83077"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83077"/>
    <dbReference type="eggNOG" id="KOG0813">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066441_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZAZ8"/>
    <dbReference type="OMA" id="FQDQCIT"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051453">
        <property type="entry name" value="MBL_Glyoxalase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46233">
        <property type="entry name" value="HYDROXYACYLGLUTATHIONE HYDROLASE GLOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46233:SF3">
        <property type="entry name" value="HYDROXYACYLGLUTATHIONE HYDROLASE GLOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="5">
        <location>
            <begin position="100"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU38809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="274" mass="29912" checksum="D9EBE4942AC54945" modified="2009-10-13" version="1">MNPWKALVYFSSLPAALGQNGGTDFSTWFNITEFPNPQVANVARLQAEAQELAQGRLWYDYVHRCINSQKYPTISNNVQTPGWVTPARAFDSLFFVGYSFVSSWAIGTGDGIILIDALNNAEEAEKVIIPGLKAFGYTARDIKALAITHEHFDHYGGAAWFQDTFNTPIYASSAAWAGMKKLQGTPSIDKTLDEGDVLEIGNTTVRVFSTPGHTPGTISLIFPVYDRGEKHVAGLYGGGGIPSKAEDKTTQVQSFLRFSRLAKDAGVDVLLSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBN4</accession>
    <name>C7ZBN4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_9124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698915">
        <property type="protein sequence ID" value="EEU38595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044308.1">
        <property type="nucleotide sequence ID" value="XM_003044262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBN4"/>
    <dbReference type="GeneID" id="9670631"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_9124"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_9124"/>
    <dbReference type="HOGENOM" id="CLU_3129799_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZBN4"/>
    <dbReference type="OrthoDB" id="4839903at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU38595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="50" mass="5669" checksum="B29FDAB36E34DD38" modified="2009-10-13" version="1" fragment="single">GKRWASNLVKRQPELRIRCFRGCDYKGAGCGGPEAICGGLYLLWHRRVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBY6</accession>
    <name>C7ZBY6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carotenoid oxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_55392</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698916">
        <property type="protein sequence ID" value="EEU38446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044159.1">
        <property type="nucleotide sequence ID" value="XM_003044113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBY6"/>
    <dbReference type="GeneID" id="9670550"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55392"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55392"/>
    <dbReference type="eggNOG" id="KOG1285">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016472_6_2_1"/>
    <dbReference type="InParanoid" id="C7ZBY6"/>
    <dbReference type="OMA" id="TWPQAQI"/>
    <dbReference type="OrthoDB" id="1069523at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF89">
        <property type="entry name" value="CAROTENOID 9,10(9',10')-CLEAVAGE DIOXYGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU38446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="56943" checksum="AB1EA7A13AC65292" modified="2009-10-13" version="1">MSKWNEDHLRFEADAYELEVIGEIPSTIHGAFYRVQPDHAFPPIFAETEIPLNGDGNVSSFYIKDGHVDFKQRYVRTPKLIAEREARQALFGRYRNKYTDDPRVQNVLKGTTANTHVVFHDNKLMALKEDARPMELDPITLETLGYIDYHGTLHCPTHTAHPKADSTTGELVSYGYEAAGDASPDICSFTVDKNGKISDEVWFQAPWPCMIHDFWATDNWVVFPINGLKASLEQMKSGGDHFYWDENLDYQLLGVIPRRGAKPEDAKWFKTPQGCYSHTINAYEEDGKLVLDANVWTDLHFPFFPNTKGERFFTDPKKVKAPILRYRFDPNGSTDKMIHPEGVLVDGINEFGRIDDRLFGKKYSRVWILKIDPTYQIKVNDHETAEGNVGFNTLVCYNFETGELQSYRHGDDSTFQEPVFVPRYEGADYEDGYILVLADRYREGRNVLLLFEASDITKGPLAEIKLPFKLMDGLHGSWVDGKEVDAAKEASEARRANGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZD04</accession>
    <name>C7ZD04_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_47993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698919">
        <property type="protein sequence ID" value="EEU38010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043723.1">
        <property type="nucleotide sequence ID" value="XM_003043677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZD04"/>
    <dbReference type="GeneID" id="9670210"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_47993"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_47993"/>
    <dbReference type="eggNOG" id="KOG3947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041441_3_1_1"/>
    <dbReference type="InParanoid" id="C7ZD04"/>
    <dbReference type="OMA" id="AIKFINC"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF18">
        <property type="entry name" value="ESTER HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="39"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="317" mass="35631" checksum="5A985B07D52A90F8" modified="2009-10-13" version="1">MQPLTSITLPGRRQREAASKLLTIHNPKVKPSRPSNPLRVVCISDTHNTRPILPPGDLLIHAGDLTENGSFEEVQAELKWLSDQPHTYKVLIAGNHDVLLDEAFLTKYPERRYGLSKTKADLDWDSVIYLEDSCIALDFPPTEPIRDVTPSSEPRRLTIFGSPWTPRYGTSAFQYRPDDELHWSTRFSSLDTKPDIIITHGPPKHHLDTRDFHRAGCPYLAEEIAQIRPRLVVSGHIHVSYGREDVVLDGVQRAYEEVMTGWAGWMTVGWMAILVLLAKLKGLVLPALSQERTVFVNASVVSGPKNVLTNEPIVVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDY1</accession>
    <name>C7ZDY1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_88249</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043522.1">
        <property type="nucleotide sequence ID" value="XM_003043476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZDY1"/>
    <dbReference type="STRING" id="660122.C7ZDY1"/>
    <dbReference type="GeneID" id="9669739"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88249"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88249"/>
    <dbReference type="eggNOG" id="KOG1414">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058862_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZDY1"/>
    <dbReference type="OMA" id="MESICTE"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000837">
        <property type="entry name" value="AP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002112">
        <property type="entry name" value="Leuzip_Jun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351:SF24">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351">
        <property type="entry name" value="FOS TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00043">
        <property type="entry name" value="LEUZIPPRJUN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="179"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="85"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU37809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="269" mass="30200" checksum="334376762DFD98F7" modified="2009-10-13" version="1">MEDNLRYVIVQGAPFMDHLDGDITMNTFDYLPDIPQEQWWAADASVFPPSFGGLDPAIHYHQGDLPYNGFTPNYGSEWSGFSSVQEYPAPSAPDSSCLEPSPSVSSRRSSASAQQDDEQQKPSAAERATSNSTKRPPSTRKNKPRGPAVEGKKDSKSRKAEPSQTTSSSSPNDADGFSKRVQERNRVASNKFRTKKREDAKKLKTDEEDMERVNRDLSSCVADLTQEVYQLKMRLLQHTDCDCALIQNYIASEAQRYIWNLDDKHEHGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEA7</accession>
    <name>C7ZEA7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_87561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698921">
        <property type="protein sequence ID" value="EEU37629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043342.1">
        <property type="nucleotide sequence ID" value="XM_003043296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEA7"/>
    <dbReference type="STRING" id="660122.C7ZEA7"/>
    <dbReference type="GeneID" id="9669405"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87561"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87561"/>
    <dbReference type="eggNOG" id="ENOG502TDPI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002639_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZEA7"/>
    <dbReference type="OMA" id="NCAGSHE"/>
    <dbReference type="OrthoDB" id="5362512at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="182"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="778" mass="87946" checksum="82A413FD08CE647C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEJ4</accession>
    <name>C7ZEJ4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_25244</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698921">
        <property type="protein sequence ID" value="EEU37706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043419.1">
        <property type="nucleotide sequence ID" value="XM_003043373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEJ4"/>
    <dbReference type="GeneID" id="9669131"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_25244"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_25244"/>
    <dbReference type="eggNOG" id="ENOG502QW7R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_734805_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZEJ4"/>
    <dbReference type="OMA" id="MAVFNEP"/>
    <dbReference type="OrthoDB" id="5229455at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="84"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU37706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="377" mass="42016" checksum="5BB9DF1CFBFDD9B7" modified="2009-10-13" version="1" fragment="single">MPPQRRSWVGCSRCKRFKKKCSEDRPTCQRCKSAGVACEYGVHLRWGGRPFNRSAFGNCLSRNELSVQRLDINRDNFIYVSPSTPQPSQAAVAVSTPPPSSSPSPSTLSKETENYDTSSSTSSEVSLLSPAKSYDLVPRRRQISLPLPVGYFSHLSPLHMSGLQYFTERTVRALAPHPQIFDELCELILPMAVFNDALLQGIVALAAVHKLASCKTSDEQTAQGLIIEGFQALSSRSLCQRLSECDDDRQLVPLLAAARTLFVCEVFAANPSRDRWSIHFRGARGLISRLQDKGLSQNPTDELRFLLRWFDMTESLVCHAASDLVSEQTTIPTPSTQSSDSEPVYIDMYLARTRDLLGVFKEIARLQHRSNKATDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZG14</accession>
    <name>C7ZG14_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ecp2 effector protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_86628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698924">
        <property type="protein sequence ID" value="EEU37072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042785.1">
        <property type="nucleotide sequence ID" value="XM_003042739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZG14"/>
    <dbReference type="STRING" id="660122.C7ZG14"/>
    <dbReference type="GeneID" id="9664808"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86628"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86628"/>
    <dbReference type="eggNOG" id="ENOG502SUB1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089018_2_2_1"/>
    <dbReference type="InParanoid" id="C7ZG14"/>
    <dbReference type="OMA" id="CNDRDSW"/>
    <dbReference type="OrthoDB" id="3552888at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35605">
        <property type="entry name" value="ECP2 EFFECTOR PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35605:SF1">
        <property type="entry name" value="ECP2 EFFECTOR PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002989097" description="Ecp2 effector protein domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="21173" checksum="689F6D9A33A209EA" modified="2009-10-13" version="1">MKTNAFISVFSATMAFASAIPQTSNVPKVVSAPIDGYEIAPMKWTGQVDKRSENITLEGTLEEITVKAREINPDFGASPSVEKRGFGKMNCGWGGKGRAGVLAIKEGIDYLQGIDGYCGLDDGPYKCARVSCSWDSAIWLCNDNDTPLRVPCKDLGPFAAKIREDCMSSGWSEPMTQGQLFGDQGNWNVIVGKDSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZG18</accession>
    <name>C7ZG18_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Polysaccharide lyase family 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_52321</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the polysaccharide lyase 9 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698924">
        <property type="protein sequence ID" value="EEU37075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042788.1">
        <property type="nucleotide sequence ID" value="XM_003042742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZG18"/>
    <dbReference type="STRING" id="660122.C7ZG18"/>
    <dbReference type="GeneID" id="9664809"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_52321"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_52321"/>
    <dbReference type="eggNOG" id="ENOG502QSUT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030634_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZG18"/>
    <dbReference type="OMA" id="ERNTAWN"/>
    <dbReference type="OrthoDB" id="5561043at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016837">
        <property type="term" value="F:carbon-oxygen lyase activity, acting on polysaccharides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053868">
        <property type="entry name" value="Pel9A-like_beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039513">
        <property type="entry name" value="PL-6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052052">
        <property type="entry name" value="Polysaccharide_Lyase_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40088">
        <property type="entry name" value="PECTATE LYASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40088:SF1">
        <property type="entry name" value="PECTATE LYASE PEL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14592">
        <property type="entry name" value="Chondroitinas_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22842">
        <property type="entry name" value="Pel9A-like_beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002987070" evidence="10">
        <location>
            <begin position="21"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Pel9A-like right handed beta-helix region" evidence="11">
        <location>
            <begin position="141"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="344"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU37075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="391" mass="41940" checksum="72DA7D0BD6288D6B" modified="2009-10-13" version="1">MAFLKLTPTLLLAILSGASAKDIFVSPTGSGSGTLDAPYGSIQSAVNAAKAGDTIYLRKGTYAPTTNIQFKTSGSKGSPITVRPYQSEKVVIDGENLPGTPKKLDEALPNGERGIFHIQNANYWSFYNLELINGPYGIYARDASNNYYEGLSTHDNYETGFQLEGASANNVVVNLDSYRNRDPRKNGESADGFACKDGTGEGNVLRNARLWDNVDDGLDLFMFGSPVTLEEVYAWGNGYNRWGFSPFEGDGNGFKLGIKNNPPANHIVKNCIAFDNLKKGFIDNGNPGTLTFERNTAWSNGDVGYNMKSSSSKMNNNIAASNDVGQVSLISSVKASGNSWNDGTTWNDKSFKSTDSSTLKGARGSDGRVKASDFLIPTSGKAIGATTKAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZI65</accession>
    <name>C7ZI65_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_86985</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698929">
        <property type="protein sequence ID" value="EEU36335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042048.1">
        <property type="nucleotide sequence ID" value="XM_003042002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZI65"/>
    <dbReference type="GeneID" id="9669045"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86985"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86985"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="InParanoid" id="C7ZI65"/>
    <dbReference type="OMA" id="LSTCGMF"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF3">
        <property type="entry name" value="HEXOSE TRANSPORTER PROTEIN (AFU_ORTHOLOGUE AFUA_8G04480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="43"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU36335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="528" mass="58572" checksum="3982DCA071D55C97" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZIE3</accession>
    <name>C7ZIE3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_87112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698930">
        <property type="protein sequence ID" value="EEU36246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041959.1">
        <property type="nucleotide sequence ID" value="XM_003041913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZIE3"/>
    <dbReference type="STRING" id="660122.C7ZIE3"/>
    <dbReference type="GeneID" id="9674317"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87112"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87112"/>
    <dbReference type="eggNOG" id="ENOG502RE9P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007898_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZIE3"/>
    <dbReference type="OMA" id="PFNYLVP"/>
    <dbReference type="OrthoDB" id="3029913at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU36246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="850" mass="94453" checksum="8ABCFA3746E35C15" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZIL9</accession>
    <name>C7ZIL9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_87190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698931">
        <property type="protein sequence ID" value="EEU36047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041760.1">
        <property type="nucleotide sequence ID" value="XM_003041714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZIL9"/>
    <dbReference type="STRING" id="660122.C7ZIL9"/>
    <dbReference type="GeneID" id="9674215"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87190"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87190"/>
    <dbReference type="eggNOG" id="KOG1607">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028277_2_2_1"/>
    <dbReference type="InParanoid" id="C7ZIL9"/>
    <dbReference type="OMA" id="KLYCLLQ"/>
    <dbReference type="OrthoDB" id="256333at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF0">
        <property type="entry name" value="LD18904P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="9">
        <location>
            <begin position="111"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU36047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="425" mass="49109" checksum="05DFF6F6D1780384" modified="2009-10-13" version="1">MSAKIRPSYYYPRRKGASAKRWFVENQIGLCLCVTVPVLLARTVAFTRPYTTKFLSLSYYDEKTGDYGLGFDDVYIVLFLVAVFTGLRAATMQYALVPLAKRFNLKGSKVTRFSEQSWMIIYYTISWNIGMYIYATSPYWLNLREMWTGWPNRETTVFMKSYMIAQLAFWLQQIIVINIEKPRKDHWQMISHHIVTIGLVYCSYRYGLTRVGNVVLVLMDLNDLFFSVAKCLKYLKHQTLCDIMFGIFVVSWVLLRHVAFCLVIWSVYAHTTEMMTGCYRGMGEDVTGPFDIPKEGSRYWLVPLISNSEIVCYDPKIMHAFLSGLLFLQGLMILWFIMIFKLVVRVLLGENAEDTRSDDEAENEQDYLEVEVGSENICLPSRSSVTGLARSDSRQRSRGVSTSLQSDGRKLLDRIGCEKKIEWEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJ19</accession>
    <name>C7ZJ19_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ABC transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_49776</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698932">
        <property type="protein sequence ID" value="EEU35999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041712.1">
        <property type="nucleotide sequence ID" value="XM_003041666.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9674107"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_49776"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_49776"/>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_27_6_1"/>
    <dbReference type="InParanoid" id="C7ZJ19"/>
    <dbReference type="OMA" id="RFTADFH"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000610">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
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    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="502"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="609"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="713"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="851"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="875"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="954"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1352"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1427"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1510"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1610"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="720"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1045"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="1387"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1699"/>
            <end position="1935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1306"/>
            <end position="1332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU35999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1950" mass="216428" checksum="27FB39A8FDF3B72E" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJC4</accession>
    <name>C7ZJC4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_9974</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003041546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJC4"/>
    <dbReference type="STRING" id="660122.C7ZJC4"/>
    <dbReference type="GeneID" id="9673963"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_9974"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_9974"/>
    <dbReference type="eggNOG" id="KOG0940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2967316_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZJC4"/>
    <dbReference type="OMA" id="WEQRIDP"/>
    <dbReference type="OrthoDB" id="3045089at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051583">
        <property type="entry name" value="YAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17616:SF8">
        <property type="entry name" value="TRANSCRIPTIONAL COACTIVATOR YORKIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17616">
        <property type="entry name" value="YES-ASSOCIATED PROTEIN YAP1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00403">
        <property type="entry name" value="WWDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="5">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU35879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="59" mass="6885" checksum="5541E5ED343CC9B6" modified="2009-10-13" version="1" fragment="single">WEERYDPASGRAYFVNHNTETTTWEHPSPLPDGWEARATSDGRAYYVNHNTKTTSWDDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKJ6</accession>
    <name>C7ZKJ6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_86178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698940">
        <property type="protein sequence ID" value="EEU35452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041165.1">
        <property type="nucleotide sequence ID" value="XM_003041119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKJ6"/>
    <dbReference type="GeneID" id="9675813"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86178"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86178"/>
    <dbReference type="eggNOG" id="ENOG502SYWK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055465_0_1_1"/>
    <dbReference type="InParanoid" id="C7ZKJ6"/>
    <dbReference type="OMA" id="QYPTGFT"/>
    <dbReference type="OrthoDB" id="5325022at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF4">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="21815" checksum="51B971470A420A50" modified="2009-10-13" version="1">MANRRPDVLEYPTGTTVLRIFQAILSVIIIIVVSFTVSAGIFAGNGLMLFTSSATLAISLWMIMAHISLAHLYNYWAGLSLDIFLLVFWIISVAVLASQTAFLWGASNDICREQDCPDAFKDATQFSGYIFAATVGLGGIEFIFSCVFLIFHGIMTFRQRRYNRIGINIESGPVETYPKHPQEPTEYHHLVPERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKM9</accession>
    <name>C7ZKM9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_51151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698940">
        <property type="protein sequence ID" value="EEU35436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041149.1">
        <property type="nucleotide sequence ID" value="XM_003041103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKM9"/>
    <dbReference type="GeneID" id="9675710"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51151"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51151"/>
    <dbReference type="eggNOG" id="ENOG502SJKY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084522_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZKM9"/>
    <dbReference type="OMA" id="IFRYGPT"/>
    <dbReference type="OrthoDB" id="2446447at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd02219">
        <property type="entry name" value="cupin_YjlB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047121">
        <property type="entry name" value="YjiB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448">
        <property type="entry name" value="BLR7373 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448:SF3">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-1" evidence="1">
        <location>
            <begin position="61"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="241" mass="26676" checksum="A170091A298D4F30" modified="2009-10-13" version="1">MAQVHKYHLFPTDLVPNSPRPLLQYKNVLTKRPDTSHCDPTEVWDMFTKNEWKVSWIFRYGATQLSHFHSQAHECMAVLSGTATIRFGVADTSEDMKENTYGSAWEEGGIELQAEAGDVFVIPAGVAHKTYNVKPDDGFKLLSPGGAHGIEADDDDPRKALSEIKLSGYTMMGAYTGGDWDFVQRGGDFEKAWSVPKPKYDPVFGQSDQGLFKTWKGTGKTPEGLKIAFKDGIAIESPLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKW8</accession>
    <name>C7ZKW8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 6A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_69981</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698941">
        <property type="protein sequence ID" value="EEU35371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041084.1">
        <property type="nucleotide sequence ID" value="XM_003041038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKW8"/>
    <dbReference type="FunCoup" id="C7ZKW8">
        <property type="interactions" value="948"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZKW8"/>
    <dbReference type="GeneID" id="9675570"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_69981"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_69981"/>
    <dbReference type="eggNOG" id="KOG0652">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_2_4_1"/>
    <dbReference type="InParanoid" id="C7ZKW8"/>
    <dbReference type="OMA" id="NKISHEH"/>
    <dbReference type="OrthoDB" id="9443236at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045899">
        <property type="term" value="P:positive regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000009">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000076">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="239"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU35371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="459" mass="50987" checksum="F46658843F33B017" modified="2009-10-13" version="1">MSTLEELDDFDHREKEEDKRDDGDKNQKKPTDGDADMKDAEEEQDDILDDEILGLSTQDILTRKRLLENDSRIMRSEYSRLSHEKAAMAEKIKENVDKIANNRQLPYLVGNVVELLDLDPTAESSEEGANIDLDATRVGKSAVIKTSTRQTIFLPLIGLVDADKLKPGDLIGVNKDSYLILDTLPAEYDSRVKAMEVDEKPTEQYTDVGGLDKQIEELVEAIVWPMKEAERFKKIGIKAPKGALMYGPPGTGKTLLARACAAQTDATFLKLAGPQLVQMFIGDGAKLVRDCFALAKEKAPAIIFIDELDAVGTKRFDSEKSGDREVQRTMLELLNQLDGFASDDRIKVLAATNRVDVLDPALLRSGRLDRKIEFPLPNEEARAQILKIHSRKMKVDPGVNWGELARSTDEFGGAMLKAVCVEAGMIALRSGKNKIGHEHYVDAIAEVQAKKKDTVNFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLN4</accession>
    <name>C7ZLN4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">beta-glucosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_44831</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4 10"/>
    <dbReference type="EMBL" id="GG698946">
        <property type="protein sequence ID" value="EEU35060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040773.1">
        <property type="nucleotide sequence ID" value="XM_003040727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLN4"/>
    <dbReference type="STRING" id="660122.C7ZLN4"/>
    <dbReference type="GeneID" id="9679208"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_44831"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_44831"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_4_0_1"/>
    <dbReference type="InParanoid" id="C7ZLN4"/>
    <dbReference type="OMA" id="PALCIPC"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF13">
        <property type="entry name" value="BETA-GLUCOSIDASE K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="11">
        <location>
            <begin position="403"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU35060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="839" mass="92189" checksum="286F1D70CF0B24D5" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZM25</accession>
    <name>C7ZM25_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_79773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698949">
        <property type="protein sequence ID" value="EEU34892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040605.1">
        <property type="nucleotide sequence ID" value="XM_003040559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZM25"/>
    <dbReference type="GeneID" id="9679072"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79773"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79773"/>
    <dbReference type="HOGENOM" id="CLU_760944_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZM25"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="364" mass="40282" checksum="06A15BAD76BE26B7" modified="2009-10-13" version="1">MEAFYTNRWKADSAITLHETSDSQCRAEQAGGYMYTFPGLKIKQAIILETRSQSCADQASTQNRGRGSRVTGPVPRAWSSKHTEIAGIKHENRPDYRPPQGLMPPLFPPDVGVASLAWAADRGAGRWMDDSGESWFSHVSKDARRECPVVIPSPSYHVGTEDALVNLPCFGELGEHRVSEEFPQPGPDGYGLKKGKIKHHPSKPTLTFGVGRAIYLWTFHLVSFSQCGEFLVIHDSKKGRPETLRVPPNFDAAASQIKRRRTPELCQPARKTKPLQSVECSDEATETGLSHHLPSMDGSRAMVKSTKTIVRKNVNPYSQVEIIQMNSSSNEQVTPISQVPTYIRATNFSVTVHTTVNNGQAICQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZM53</accession>
    <name>C7ZM53_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_14339</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698949">
        <property type="protein sequence ID" value="EEU34906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040619.1">
        <property type="nucleotide sequence ID" value="XM_003040573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZM53"/>
    <dbReference type="FunCoup" id="C7ZM53">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="GeneID" id="9679055"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_14339"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_14339"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_1_1"/>
    <dbReference type="InParanoid" id="C7ZM53"/>
    <dbReference type="OMA" id="YFIVERR"/>
    <dbReference type="OrthoDB" id="3357846at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU34906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="49919" checksum="AB5C78AFE603FDC5" modified="2009-10-13" version="1" fragment="single">IVVDWYGANDLANPKNWPVYKKVLIFAVVNYSNMVVYMSSSIYAASQKGMMEEFGVSSTVANLGLALFVLGYGFGPMIMSPLSDVDHIGRNPPYLISSTIFLLLSVLTATVGNVEGLMVLRFLQGFFGSPMLASGGASLGDVCNENVQPLALYTWACSGFAAASIAPILSSFTVPIMGWRWSLWEIVILNAPTLMTPETSRGKILYMRLQRLQKRYPEIHMITAVQAKSPRPTTSGLWNAVVVPVQMHLLDPSITFTSVYSGFVYGIYYSFFEVLPFVYEGIYQLPSDMASLAYLSVVVGVFLIGIPYCGYIYFYALPLSQKGVSIAPEQRLIPALFSSFLVPGGLFLFAWTSRPSIHWMVPTLGIAMTSAGIVIIIQCIFVYLSLSYPLYAASAFGGNSFLRSLIAFAALLWSKPLYHELGVGGGSSLLGGLCIFGVAGIFILYRYGAALRMKSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMC0</accession>
    <name>C7ZMC0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_88406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698951">
        <property type="protein sequence ID" value="EEU34826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040539.1">
        <property type="nucleotide sequence ID" value="XM_003040493.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9678973"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88406"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88406"/>
    <dbReference type="eggNOG" id="ENOG502RFWN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000692_0_1_1"/>
    <dbReference type="InParanoid" id="C7ZMC0"/>
    <dbReference type="OMA" id="LHIAFDH"/>
    <dbReference type="OrthoDB" id="5096121at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1237"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1246"/>
            <end position="1285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1285" mass="145163" checksum="4CE2DB65788CD3BF" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNC0</accession>
    <name>C7ZNC0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cutinase</fullName>
            <ecNumber evidence="3">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_55040</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cutinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="3"/>
    <dbReference type="EMBL" id="GG698965">
        <property type="protein sequence ID" value="EEU34505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040218.1">
        <property type="nucleotide sequence ID" value="XM_003040172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNC0"/>
    <dbReference type="ESTHER" id="nech7-c7znc0">
        <property type="family name" value="Cutinase"/>
    </dbReference>
    <dbReference type="GeneID" id="9678033"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55040"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55040"/>
    <dbReference type="eggNOG" id="ENOG502SI38">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040058_2_0_1"/>
    <dbReference type="InParanoid" id="C7ZNC0"/>
    <dbReference type="OMA" id="KIFCLPT"/>
    <dbReference type="OrthoDB" id="3225429at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000235">
        <property type="entry name" value="Cutinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF3">
        <property type="entry name" value="CUTINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00129">
        <property type="entry name" value="CUTINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002987257" description="cutinase" evidence="13">
        <location>
            <begin position="17"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="47"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="187"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU34505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="228" mass="24083" checksum="BEB65557704BB7D3" modified="2009-10-13" version="1">MKFLPFVALLAGLSRALPLDAAANDGSLTTRALFSSDELLDGDAGSCPSAILVYARGSLEFGNLGFLGGLVGDGIKTVLGEDQVWTQGVGGDYSAAIGDNGLPDGTSPEAIQEMIGLFELADKKCPNATLVSGGWSQGAALVAASIRDLNPTIRGKIAGVILFGYTKNKQNNGRIPNYPADRLRVFCNDGDAVCEGELSITIPHLFYLSEARREAPEFLIEQINKYQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNN6</accession>
    <name>C7ZNN6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_85452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039734.1">
        <property type="nucleotide sequence ID" value="XM_003039688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNN6"/>
    <dbReference type="GeneID" id="9677574"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85452"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85452"/>
    <dbReference type="HOGENOM" id="CLU_114629_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZNN6"/>
    <dbReference type="OMA" id="PYPVQQW"/>
    <dbReference type="OrthoDB" id="5017895at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU34021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="220" mass="24953" checksum="427D81AF0F5045E3" modified="2009-10-13" version="1">MSYFNQNNAQNVPIYICPQTSTQPGLTYASNQNQQFVLQPIANNQQQPPRGMGHPMQNPMTYQHWWNQHTLPSDPRSPNSLYRQNPQALVAARNTVYGPQGDALREVPRPGGYHLEGEWHVGYLGHQITQRQQRTDPDTGPFGLSVWVHQDSRPTQTTQSDRQLWSIGLTRMAGRSDCGLKVVCQTVCQTVALYAAEISGIHVCNVDRNGYVQWIWQGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZP30</accession>
    <name>C7ZP30_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_85516</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039763.1">
        <property type="nucleotide sequence ID" value="XM_003039717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZP30"/>
    <dbReference type="GeneID" id="9677603"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85516"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85516"/>
    <dbReference type="eggNOG" id="ENOG502RZ2S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006926_1_1_1"/>
    <dbReference type="InParanoid" id="C7ZP30"/>
    <dbReference type="OMA" id="NDTESMY"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU34050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="718" mass="80768" checksum="EAC869BB129D3D53" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPY4</accession>
    <name>C7ZPY4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_89030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698975">
        <property type="protein sequence ID" value="EEU33923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039636.1">
        <property type="nucleotide sequence ID" value="XM_003039590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZPY4"/>
    <dbReference type="GeneID" id="9667168"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89030"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89030"/>
    <dbReference type="eggNOG" id="ENOG502QSDU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014119_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZPY4"/>
    <dbReference type="OMA" id="WSHHSAI"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU33923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="646" mass="72991" checksum="69559117A9D03A74" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQR0</accession>
    <name>C7ZQR0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_89282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699007">
        <property type="protein sequence ID" value="EEU33643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039356.1">
        <property type="nucleotide sequence ID" value="XM_003039310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQR0"/>
    <dbReference type="GeneID" id="9666878"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89282"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89282"/>
    <dbReference type="eggNOG" id="KOG1576">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_7_1_1"/>
    <dbReference type="InParanoid" id="C7ZQR0"/>
    <dbReference type="OMA" id="QNCTPSF"/>
    <dbReference type="OrthoDB" id="5286008at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045290">
        <property type="term" value="F:D-arabinose 1-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070485">
        <property type="term" value="P:dehydro-D-arabinono-1,4-lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686:SF1">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU33643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="402" mass="44039" checksum="7F42879221C50FDF" modified="2009-10-13" version="1">MGSIQTSSPTHTGLNPPPLVMGGAGFSYQLHPEPQSLPIINILLRAFELGVRTIDTSPYYEPSEQLMGAALSHANIQSKYKRGDYKLMTKVGRIKENKFNYSPDWIRKSVARSLERFQTTYLDVVFCHDVEYVSIDEAVTAVGVLLELQRACVILRVGISGYDIDVLAEVASTVRKRYGHPVDVVQTWAQLTLHNTQVETRGFELFRAAGVNSVFCSSPLAVGLLRTGGIPRGLTGDWHPAPEGLREAAAEAAKWVESHGKGESLSSVALQYAILKARQSCTSSFTVSTITGISNLSDLEQNVAAAKRILKVAPFTGNEASESLQSYNQLDQEALERNWPLFERVRSILGEWIDYDFSGSNTKAREEVSLPNGTNSTKKDAVQVSAMDRDSLIQSTVVQAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQR9</accession>
    <name>C7ZQR9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_19117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699009">
        <property type="protein sequence ID" value="EEU33633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039346.1">
        <property type="nucleotide sequence ID" value="XM_003039300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQR9"/>
    <dbReference type="GeneID" id="9666875"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_19117"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_19117"/>
    <dbReference type="eggNOG" id="ENOG502SN4M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066073_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZQR9"/>
    <dbReference type="OMA" id="EPEFAYF"/>
    <dbReference type="OrthoDB" id="72726at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU33633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="187" mass="21144" checksum="DFCE803F2D73AF3C" modified="2009-10-13" version="1" fragment="single">LASTLRLLPGLRLDILTVLGLRTKEVSYDTLNSLIRESCGWKELQYISHSSEVLGFAKLERLHFGDESILEDRDGALSRPPVAIYRSTVSDCPGSVINVNARARFEQKMPEDTAAQEAFGIAEDAGLMAYGERGKKIMIIVKRGAGVNYEQKKDSRFIQSDIRRDMPGKTWKEIRYECIDRIFVDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZR95</accession>
    <name>C7ZR95_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7923 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_89465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699050">
        <property type="protein sequence ID" value="EEU33462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039175.1">
        <property type="nucleotide sequence ID" value="XM_003039129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZR95"/>
    <dbReference type="STRING" id="660122.C7ZR95"/>
    <dbReference type="GeneID" id="9666695"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89465"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89465"/>
    <dbReference type="eggNOG" id="ENOG502SM7V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031811_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZR95"/>
    <dbReference type="OMA" id="FIRGFNM"/>
    <dbReference type="OrthoDB" id="2270193at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057683">
        <property type="entry name" value="DUF7923"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543:SF1">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25540">
        <property type="entry name" value="DUF7923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7923" evidence="3">
        <location>
            <begin position="69"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU33462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="404" mass="44728" checksum="4E171FB1F201CB62" modified="2009-10-13" version="1">MASSESQLDELKSAWNTCKAHDNERCNLIELSDAQSDLRDKKDLLHLERERLDDATRQLQDFLHEKDGHMFASVLIDGDCMPFKDDLVSQGLEGGQKTASLLRQAVDEDLKCTMGSGASHVRVIVRVYANLKGLAKTYKDHDILSDLATLFEFVRGFNMGDDLCDFVDAGNGKECADEKIKATFRINVVDVHCRQILFGGAPDNGYARLLGPYKEDKTACRRITLLEGPPFANELADLKDSFRTTASFAKIFRSEKLPTMKRRVSFRLSAPGSPSTNYAAAAAAKPPPASTPQASPTVPGRSLLFGVVHHNRLGQRVDAPLPQYSREDFFSLKSRKLCNAFHLLGACPYEDKYGICNHDHDGKLSDKQLLALAAIARQSPYQMGLDYSSAAIRSIKSDQDPNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZRK9</accession>
    <name>C7ZRK9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_64954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG699099">
        <property type="protein sequence ID" value="EEU33348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039061.1">
        <property type="nucleotide sequence ID" value="XM_003039015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZRK9"/>
    <dbReference type="STRING" id="660122.C7ZRK9"/>
    <dbReference type="GeneID" id="9667208"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_64954"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_64954"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_8_0_1"/>
    <dbReference type="InParanoid" id="C7ZRK9"/>
    <dbReference type="OMA" id="HRENHEM"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF37">
        <property type="entry name" value="CLAVALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU33348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="291" mass="31706" checksum="C032F3408EC004D5" modified="2009-10-13" version="1">MTLGKKHDCEFDSDPRQNKELANSLRDKHVIIAGAGRGIGRATAELFAYTAISSLSIFALELTEVNETGRLCSAINPALAVRTAALDVTDFSAVQQFVDRTAHEFGRIDVVFMNAGRPPQFLPVHESEPTIWWDTVAISLQGSFNLARATLPLMRQSSNGGTLIFTSSAGAHATEGMGSYTIGKLGVSRLAEILYHENKHAGIRTFSLHPGKSAKAVVSFFKDIPFDTPQMPAGMVVVLASGRLDFLSGRYVDSTKTVAEYIADKDGILNEDAYRVKLLLGRGEFLPEWKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C7YGU1</accession>
    <name>C7YGU1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 16">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">NECHADRAFT_102366</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="function">
        <text evidence="16">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054231.1">
        <property type="nucleotide sequence ID" value="XM_003054185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YGU1"/>
    <dbReference type="FunCoup" id="C7YGU1">
        <property type="interactions" value="1206"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YGU1"/>
    <dbReference type="GeneID" id="9676846"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102366"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102366"/>
    <dbReference type="eggNOG" id="KOG0070">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_9_3_1"/>
    <dbReference type="InParanoid" id="C7YGU1"/>
    <dbReference type="OMA" id="HYYANTN"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003500">
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    </dbReference>
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        <location>
            <begin position="24"/>
            <end position="31"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:37565"/>
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            <position position="31"/>
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        <ligand>
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            <position position="48"/>
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        <ligand>
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    <sequence length="183" mass="20975" checksum="96BD04972B0114CE" modified="2009-10-13" version="1">MGLAFSKLFDRLWGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNIQFTVWDVGGQDKIRPLWRHYFQNTQGIIFVVDSNDRDRIVEAREELQRMLNEDELRDAILLVFANKQDLPNAMNAAEITDKLGLHSLRQRAWYIQSTCATSGDGLYEGLEWLANTLRKAGHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7YGX5</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">NECHADRAFT_74774</name>
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            <taxon>Sordariomycetes</taxon>
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            <taxon>Nectriaceae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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    </dbReference>
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        </location>
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        </location>
    </feature>
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            <begin position="586"/>
            <end position="608"/>
        </location>
    </feature>
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        <location>
            <begin position="33"/>
            <end position="51"/>
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    </feature>
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            <begin position="180"/>
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        </location>
    </feature>
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            <begin position="205"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEU48533.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="608" mass="69245" checksum="6FCCBA6FFBAC87E3" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
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    </gene>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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            <taxon>Fusarium vanettenii</taxon>
        </lineage>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
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                <person name="Salamov A."/>
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                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EEU47830.1"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zinc_finger_trans_reg"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="401"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="90"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="500"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="508"/>
            <end position="531"/>
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    </feature>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU47830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="742" mass="83044" checksum="1050F6A2FAD5397D" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7YH96</accession>
    <name>C7YH96_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Threonylcarbamoyl-AMP synthase</fullName>
            <shortName evidence="14">TC-AMP synthase</shortName>
            <ecNumber evidence="3 14">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 14">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">NECHADRAFT_74894</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Likely catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Required for normal translation, by ensuring translation fidelity at the level of codon recognition, appropriate translation initiation selection and maintenance of reading frame. Also involved in telomere replication. Binds to single-stranded telomeric (ssTG) DNA and positively regulates telomere length.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="3 14"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053592.1">
        <property type="nucleotide sequence ID" value="XM_003053546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YH96"/>
    <dbReference type="FunCoup" id="C7YH96">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YH96"/>
    <dbReference type="GeneID" id="9674465"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74894"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74894"/>
    <dbReference type="eggNOG" id="KOG3051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031397_0_0_1"/>
    <dbReference type="InParanoid" id="C7YH96"/>
    <dbReference type="OMA" id="RTQRWKS"/>
    <dbReference type="OrthoDB" id="412787at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000008">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010923">
        <property type="entry name" value="T(6)A37_SUA5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00057">
        <property type="entry name" value="L-threonylcarbamoyladenylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF16">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="Sua5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004930">
        <property type="entry name" value="Tln_factor_SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="16">
        <location>
            <begin position="39"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR004930-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEU47879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="431" mass="46304" checksum="DDF840D1FD225670" modified="2009-10-13" version="1">METRIVKVSSKGSLGRFRPGEGLARLDHWEVQCEDKSALKALEKAAHELRTTPTPVAFPTETVYGLGADATRSPSVKGIYSAKGRPSDNPLISHVCDLEMLREYIGQIEGGQDPIPSRYRALIERFWPGPLTILLPNPQPTKLAPEVTAGLKTFGVRMPSSPLALSLIKLAGVPLAAPSANASTKPSPTTAQHVMDDLRGRIELILDGGQCAVGVESTVVDGLCDPPVVLRPGGIGLDELRSCPGWEGAVIAYKDQSEEGKAAPRAPGMKYKHYSPKARVVLYESSCAKGATGVASSELATATNGAVNGHATNGEKKMRKIGVIRTQRWKQGAGLRCASLQRQKTVDQDQDSPFDVVEGDLLDENEKPIGKILDIDLGRDTEGIARGLFSALREFDRQGADTIFVEGIEDRIDIAAAVMNRLRKAASEIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHE7</accession>
    <name>C7YHE7_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_74945</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
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            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="9664488"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74945"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74945"/>
    <dbReference type="eggNOG" id="KOG0270">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023867_0_1_1"/>
    <dbReference type="InParanoid" id="C7YHE7"/>
    <dbReference type="OMA" id="CFVPRGV"/>
    <dbReference type="OrthoDB" id="270624at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="rRNA processing protein Pwp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001345">
        <property type="entry name" value="WD40 repeat-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
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            <begin position="269"/>
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        <location>
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            <end position="440"/>
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    </feature>
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        <location>
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            <end position="113"/>
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    </feature>
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        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
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            <end position="519"/>
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        <location>
            <begin position="520"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEU48619.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="538" mass="60154" checksum="32ED75B1937B9852" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHZ9</accession>
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        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">NECHADRAFT_75145</name>
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            <taxon>Sordariomycetes</taxon>
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        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="GeneID" id="9674740"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75145"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75145"/>
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    </dbReference>
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    <dbReference type="InParanoid" id="C7YHZ9"/>
    <dbReference type="OMA" id="EVRVCWL"/>
    <dbReference type="OrthoDB" id="3360032at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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            <end position="233"/>
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    </feature>
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            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU48723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="233" mass="25725" checksum="ED8AB0A7EEA0DDA1" modified="2009-10-13" version="1">MFLLALRHLLPILGLILFLTSSTEANAEKVIFTAPDVVPIPLQKPSLADLNLPVLTPDSWSIRTNLSRVFPTEPKDYASGAATWLLLDSLNAGQRYEFRQPTGFVMDVYELDTVWGTPELMQSLADFAYSRQSSTDSHGDREEGERSASVLLLQIKASADYFTDDAALMRDPPPVLVDLILDPYLYSLIPRSLVPTIGFLVVVGLVAWFVARSVASKLQSIAVAGESREKKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7YI09</accession>
    <name>C7YI09_FUSV7</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">NECHADRAFT_75155</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
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                <person name="Salamov A."/>
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                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
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                <person name="Covert S.F."/>
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            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="660122.C7YI09"/>
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    <dbReference type="KEGG" id="nhe:NECHADRAFT_75155"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75155"/>
    <dbReference type="eggNOG" id="ENOG502T2GG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_362098_0_0_1"/>
    <dbReference type="InParanoid" id="C7YI09"/>
    <dbReference type="OMA" id="YYQPESH"/>
    <dbReference type="OrthoDB" id="1703270at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="752"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU48727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="779" mass="85416" checksum="98DA2D4258232CC8" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIF9</accession>
    <name>C7YIF9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA ligase D 3'-phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_75306</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053803.1">
        <property type="nucleotide sequence ID" value="XM_003053757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIF9"/>
    <dbReference type="GeneID" id="9676431"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75306"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75306"/>
    <dbReference type="eggNOG" id="ENOG502SF29">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040687_0_0_1"/>
    <dbReference type="InParanoid" id="C7YIF9"/>
    <dbReference type="OMA" id="SIHQRKW"/>
    <dbReference type="OrthoDB" id="2588098at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014144">
        <property type="entry name" value="LigD_PE_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39465:SF1">
        <property type="entry name" value="DNA LIGASE D 3'-PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39465">
        <property type="entry name" value="DNA LIGASE D, 3'-PHOSPHOESTERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13298">
        <property type="entry name" value="LigD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA ligase D 3'-phosphoesterase" evidence="3">
        <location>
            <begin position="103"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU48090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="332" mass="37024" checksum="F61BE4A8F0EFB6B2" modified="2009-10-13" version="1">MTKKRPPSPNLIPNPFIKKKNLEWTLDSPSTTQTAHSSLIPLPPPTTADIESGSTTIDDHLSHFQAHLSKHVITPSPLLSIQSYASLYSSNIGNPEGAHFVIHQHDHPIAGTHYDLRLQINETSSASWAIMYGLPGDPNSTRLNRNATETRIHCLWAHYLYGTLEHTLYSPGGASTHRHPIPHHHHHHQIHHPKQPHKLSYTPPFKDARSASACTALAYRTLTFLTSASPNQRTLLGERKVDERLELNAVVGVEALRSHTANAEKLSAMEREIRELEDEQVRLTNAYPGASNTIGSVHQRRCVVTGQRGADILKDEGVNNFVQRKGWKPVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIH5</accession>
    <name>C7YIH5_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_75324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054518.1">
        <property type="nucleotide sequence ID" value="XM_003054472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIH5"/>
    <dbReference type="GeneID" id="9676439"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75324"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75324"/>
    <dbReference type="eggNOG" id="ENOG502R0P1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1086219_0_0_1"/>
    <dbReference type="InParanoid" id="C7YIH5"/>
    <dbReference type="OMA" id="FWTEANI"/>
    <dbReference type="OrthoDB" id="4589291at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU48805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="256" mass="29885" checksum="06BF3888AC37E255" modified="2009-10-13" version="1">MSRQPNSDVDPPAGLVSNFFEKLAHGFNNAFSRQAENETPQRGSEASSSRMSCRCHLAEEMAWVLEIKFASDLDVPRDTTPEWRAFLQVNAHDVPKLMREGFYWSEANVDQERGEYACYPHEENSSLQRFCRTYHLDDLQDDPQWVAELIVHSHELRVLSEFRIRNLKIEDTLSAVAYRTHDHWVYYYHVNAPWQCINAIYDDMPLKGWWPWPKELKAEAETEDEIENEVEEEAEDEAEDEAEAEAENEAEDEAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>C7YII0</accession>
    <name>C7YII0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isoleucine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">NECHADRAFT_75329</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="3"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054522.1">
        <property type="nucleotide sequence ID" value="XM_003054476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YII0"/>
    <dbReference type="FunCoup" id="C7YII0">
        <property type="interactions" value="744"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YII0"/>
    <dbReference type="GeneID" id="9676443"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75329"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75329"/>
    <dbReference type="eggNOG" id="KOG0433">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_7_2_1"/>
    <dbReference type="InParanoid" id="C7YII0"/>
    <dbReference type="OMA" id="HCWRCKT"/>
    <dbReference type="OrthoDB" id="10264412at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07960">
        <property type="entry name" value="Anticodon_Ia_Ile_BEm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000111">
        <property type="entry name" value="Mitochondrial isoleucyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.830">
        <property type="entry name" value="Ile-tRNA synthetase CP2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
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        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
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        <property type="entry name" value="Anticodon_Ile_BEm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050081">
        <property type="entry name" value="Ile-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="14">
        <location>
            <begin position="35"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="15">
        <location>
            <begin position="700"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEU48809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="950" mass="106119" checksum="2B373B131F999837" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIT6</accession>
    <name>C7YIT6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Maintenance of telomere capping protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_90424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053866.1">
        <property type="nucleotide sequence ID" value="XM_003053820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIT6"/>
    <dbReference type="FunCoup" id="C7YIT6">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YIT6"/>
    <dbReference type="GeneID" id="9676495"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90424"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90424"/>
    <dbReference type="eggNOG" id="ENOG502QU4J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034224_0_1_1"/>
    <dbReference type="InParanoid" id="C7YIT6"/>
    <dbReference type="OMA" id="RIHLVHD"/>
    <dbReference type="OrthoDB" id="5594977at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018814">
        <property type="entry name" value="DUF5427"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265:SF1">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10310">
        <property type="entry name" value="DUF5427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU48153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="54018" checksum="49631A0637D831F1" modified="2009-10-13" version="1">MAPKKTKAADDDNLDDLFSGIDTKPKKTTKAKPTSAASKAIADQDILADLESELAAEQPSRPHTPRLKDAARRSTATPPAGDPRKSTDSARSLRASFTPSATSSELHEAEKKPAPEPAQPAPQQSGGGWWGGILSTASAAMKQAEAAVTQIQQNEEAKKWADQVKGIRGLDVTTLRTYGDELRHRALPTFTNILHTLAPPISSHERLLIHITHDLVGYPSLDPLIHNVFGHVMSQVEGGDLLVVQRGQESHSRRSTDNPTGWHDGPWWRQADSPRELGLIKGLAEGTKLCRANAESYATEYFAASGGLEEAKHKATEDVSESNPVRTSDLFLAVQAIAVDDDKTLFARTASAEREKDSSTVENQEENEELICFAVFILDPVHDIEFYTVSQTVPARWVQWLDSAGPLTPRSGEEGDESEINVPEEIRDIIESGGVDPREWVAEWLEELLNLSVGIVAQRYVARRMGVGEGGLGKGKRRMEDLVQDNAGEAARAGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJE0</accession>
    <name>C7YJE0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U3 small nucleolar RNA-associated protein 11</fullName>
            <shortName evidence="6">U3 snoRNA-associated protein 11</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_99031</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Nucleus</location>
            <location evidence="2 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UTP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054674.1">
        <property type="nucleotide sequence ID" value="XM_003054628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJE0"/>
    <dbReference type="FunCoup" id="C7YJE0">
        <property type="interactions" value="733"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YJE0"/>
    <dbReference type="GeneID" id="9663827"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_99031"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_99031"/>
    <dbReference type="eggNOG" id="KOG3237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061887_0_1_1"/>
    <dbReference type="InParanoid" id="C7YJE0"/>
    <dbReference type="OMA" id="KWKVRER"/>
    <dbReference type="OrthoDB" id="29058at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007144">
        <property type="entry name" value="SSU_processome_Utp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03998">
        <property type="entry name" value="Utp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015952">
        <property type="entry name" value="U3snoRNP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="141"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU48961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="271" mass="31482" checksum="A6F2EECFD4ECFC7D" modified="2009-10-13" version="1">MSSMRNAVARRPHRERAQPLERQRLGLLEKHKDYSLRAKDFNKKKATLKALRDKAAERNEDEFYFGMLSRKGPGNRVKDGKKWSGTVQGDRGNKVLDVDTVRLLKTQDIGYIRTMRQVVAKEVAKLEEQVVLTRGFDKLGKDEEEEQDDDDNEFDFATAPSKPKAPRKIVFMDDEEQRENVIRQKMEDDDEDVADKTFEGFDDEKKEDAELERAKSLRRLQLQLENARKKLHTLKTAEEELEIQRAKMAKTATSGGTTRKGKKIMVRTRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJG1</accession>
    <name>C7YJG1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1264 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_73446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OBAP family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053984.1">
        <property type="nucleotide sequence ID" value="XM_003053938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJG1"/>
    <dbReference type="GeneID" id="9663841"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_73446"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_73446"/>
    <dbReference type="eggNOG" id="ENOG502QR3B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071931_2_1_1"/>
    <dbReference type="InParanoid" id="C7YJG1"/>
    <dbReference type="OMA" id="RHVEAHH"/>
    <dbReference type="OrthoDB" id="1901244at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010686">
        <property type="entry name" value="OBAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31360:SF0">
        <property type="entry name" value="OIL BODY-ASSOCIATED PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06884">
        <property type="entry name" value="DUF1264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU48271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="25800" checksum="864C124593A87D96" modified="2009-10-13" version="1">MASSQREEIPITNEGMGQPLSATNQVLTAGAAVTQDFRPVKSICAHLNAFHAYADDPKRFVEANHYCAHLNEDVRQCLLYDSDEPTARLIGIEYMITPKLYDTLSKEERKLWHSHAYEVKSGMLIMPNRAVPESAWEVAENMEMDQVVHLYGKVYHLWQTDRGDMLPLGPPKLMTSFTADGQLDFKHVRDRDRRFGVDHKQKREARKDIPVPAIHEDADQAWKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7YKN2</accession>
    <name>C7YKN2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_98757</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053482.1">
        <property type="nucleotide sequence ID" value="XM_003053436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YKN2"/>
    <dbReference type="STRING" id="660122.C7YKN2"/>
    <dbReference type="GeneID" id="9676814"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_98757"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98757"/>
    <dbReference type="eggNOG" id="ENOG502SDP0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033452_0_0_1"/>
    <dbReference type="InParanoid" id="C7YKN2"/>
    <dbReference type="OMA" id="KPDMDCV"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051775">
        <property type="entry name" value="Homeobox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24323">
        <property type="entry name" value="CEH-10 HOMEODOMAIN-CONTAINING HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24323:SF7">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="51"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="53"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="132"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="253"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="402"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="415"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="514"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="527"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU47769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="580" mass="63512" checksum="13ADA0C67B157C21" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7YKN5</accession>
    <name>C7YKN5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="8">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_90019</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="8"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053483.1">
        <property type="nucleotide sequence ID" value="XM_003053437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YKN5"/>
    <dbReference type="FunCoup" id="C7YKN5">
        <property type="interactions" value="546"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YKN5"/>
    <dbReference type="GeneID" id="9664276"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90019"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90019"/>
    <dbReference type="eggNOG" id="KOG2867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030733_0_0_1"/>
    <dbReference type="InParanoid" id="C7YKN5"/>
    <dbReference type="OMA" id="SWIKINA"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016325">
        <property type="entry name" value="Phstyr_phstse_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="18"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="366"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU47770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="430" mass="47679" checksum="D9D9E4435288D098" modified="2009-10-13" version="1">MSSRHLTLVAPRAAVSGAASSIPSLKDRLPKLEPRRRRQTPGNPTPIPETPALPAPPDTSNWTYKTPSRRILSRQDHDIFLSSPTCKLITGWVFGLAESVVDVPNSSVHDSDLSSPIKTILSILDEAEQLVAKSPPNEQGGSRFGNKAFRGFLDLAEKNSPAWHRQLGLENDEAITELSTYFCQSFGNGNRIDYGSGHELNFMIWLLCLYQLGVVQKSDFKPLVLRVFVRYLAVMRIVQMTYYLEPAGSHGVWGLDDYQFLPFLFGASQLLHHPYITPRAIHQDLTLEEFGEEYMYLGQVSFVNSTKTVKGLRWHSPMLDDISSAKSWTKIDGGMRRMFVAEVLGKLPVMQHFLFGSLVPAADGMSEEDAAGFEEEEAEHDHSGHSHTGVAHDGTGWGDCCGIKVPSSLAAAQEMKKRGAGQALRRIPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLE4</accession>
    <name>C7YLE4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane ATPase</fullName>
            <ecNumber evidence="10">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_77500</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="10"/>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052960.1">
        <property type="nucleotide sequence ID" value="XM_003052914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YLE4"/>
    <dbReference type="STRING" id="660122.C7YLE4"/>
    <dbReference type="GeneID" id="9671016"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77500"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77500"/>
    <dbReference type="eggNOG" id="KOG0205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_6_0_1"/>
    <dbReference type="InParanoid" id="C7YLE4"/>
    <dbReference type="OMA" id="FWILIAW"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000005">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000008">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="412"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="773"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="800"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="834"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="874"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="902"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="942"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="12">
        <location>
            <begin position="87"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="254"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU47247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1028" mass="113734" checksum="E4BB15D3C27FE359" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLH0</accession>
    <name>C7YLH0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine amidotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_103671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052973.1">
        <property type="nucleotide sequence ID" value="XM_003052927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YLH0"/>
    <dbReference type="FunCoup" id="C7YLH0">
        <property type="interactions" value="118"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YLH0"/>
    <dbReference type="GeneID" id="9671029"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_103671"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_103671"/>
    <dbReference type="eggNOG" id="KOG3179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054974_0_2_1"/>
    <dbReference type="InParanoid" id="C7YLH0"/>
    <dbReference type="OMA" id="HQIVRYG"/>
    <dbReference type="OrthoDB" id="92161at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="89"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU47260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="247" mass="27358" checksum="94CE8EC3837A680B" modified="2009-10-13" version="1">MTRTFRLAVLECDTPFPSVNASRGSYGNIFRDLLVKGLDGLGEKGSDVSLDLSKWDVVTAQEYPNVDDVDGFLLTGSKFTAFHDDPWILKLVDFVSKVYTTTKKPIVGICFGHQIIGRALGANVGLSPGGWEICVDRINLNETGQKLLGVSSLGLHQMHRDAVLDVPKGLVSLGSSPRCEVQGLYEPGRVISFQAHPEFDDFIMSEIMEARYEQKIFDKDMYEEGITRARAAHDGVLVSSKIWEFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C7YMP5</accession>
    <name>C7YMP5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WH1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_92045</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052700.1">
        <property type="nucleotide sequence ID" value="XM_003052654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YMP5"/>
    <dbReference type="FunCoup" id="C7YMP5">
        <property type="interactions" value="191"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YMP5"/>
    <dbReference type="GeneID" id="9664111"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_92045"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_92045"/>
    <dbReference type="eggNOG" id="KOG3671">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015385_1_1_1"/>
    <dbReference type="InParanoid" id="C7YMP5"/>
    <dbReference type="OMA" id="EYNQDRK"/>
    <dbReference type="OrthoDB" id="8963340at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045010">
        <property type="term" value="P:actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01205">
        <property type="entry name" value="EVH1_WASP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000281">
        <property type="entry name" value="Actin associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051412">
        <property type="entry name" value="Formin_Homology_Diaphanous_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033927">
        <property type="entry name" value="WASPfam_EVH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691:SF6">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00461">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00246">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH1" evidence="3">
        <location>
            <begin position="17"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="WH2" evidence="4">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="415"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="539"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="558"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU46987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="605" mass="63219" checksum="33762ABB56FA65EB" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNC6</accession>
    <name>C7YNC6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_35964</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053313.1">
        <property type="nucleotide sequence ID" value="XM_003053267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNC6"/>
    <dbReference type="FunCoup" id="C7YNC6">
        <property type="interactions" value="904"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YNC6"/>
    <dbReference type="GeneID" id="9664379"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_35964"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_35964"/>
    <dbReference type="eggNOG" id="KOG1315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034009_0_0_1"/>
    <dbReference type="InParanoid" id="C7YNC6"/>
    <dbReference type="OMA" id="SFYTKDV"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="141"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU47600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="409" mass="46350" checksum="9E08660CB7220083" modified="2009-10-13" version="1">MPRPATSNRAETRWTVRLVPFFCAAAIGYATYLTVAHLCVNYLLREKKKTAVAVVLLVLYFVFFILTVATYFRTFLTIQFKTGFVPLTPEREALDQEREQIKKRGGDLEALPWVPPDTNPDSPGLETFYSRDVFVCESDGRPRWCSECRNWKPDRAHHSSDLDRCVRKMDHLCPWVGGVVGENSFNFFVQFTSYCASYCTVCLATSGYSLHLKMQDGESLDARIVVGIALAGLFCLFTSAMTMTSARFVFTNITNIDLFKKNQVFRLAVRVSHTTRPTDRFQTIVYPLSPVCSSSTTFSRGQLNSVNRSRTPSPEPRMAARDQQARRTFAILTTEPGENPWDLGYWGNFKSVMGNSVFEWLLPIRHSPCCNHDSMVSDYEYGPLIEVLKRRYGITDGGPAKEGIEMTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNU2</accession>
    <name>C7YNU2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_79425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051891.1">
        <property type="nucleotide sequence ID" value="XM_003051845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNU2"/>
    <dbReference type="GeneID" id="9672970"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79425"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79425"/>
    <dbReference type="eggNOG" id="ENOG502SKW0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_472585_0_0_1"/>
    <dbReference type="InParanoid" id="C7YNU2"/>
    <dbReference type="OMA" id="IATSNCH"/>
    <dbReference type="OrthoDB" id="5376140at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU46178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="577" mass="64227" checksum="1279E6E3FE46CC82" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7YP82</accession>
    <name>C7YP82_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hpc2-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_92448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051513.1">
        <property type="nucleotide sequence ID" value="XM_003051467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YP82"/>
    <dbReference type="STRING" id="660122.C7YP82"/>
    <dbReference type="GeneID" id="9673118"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_92448"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_92448"/>
    <dbReference type="eggNOG" id="ENOG502RG9A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012566_0_0_1"/>
    <dbReference type="InParanoid" id="C7YP82"/>
    <dbReference type="OMA" id="MDGDVPM"/>
    <dbReference type="OrthoDB" id="5576775at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014840">
        <property type="entry name" value="HRD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08729">
        <property type="entry name" value="HUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hpc2-related" evidence="2">
        <location>
            <begin position="513"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
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            <end position="35"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
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            <begin position="174"/>
            <end position="184"/>
        </location>
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            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
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        </location>
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    </feature>
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        </location>
    </feature>
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            <begin position="560"/>
            <end position="571"/>
        </location>
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            <begin position="579"/>
            <end position="605"/>
        </location>
    </feature>
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    </feature>
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        <location>
            <begin position="641"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEU45800.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="659" mass="70167" checksum="3C18A0B223AF24A0" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPK3</accession>
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        </submittedName>
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        <name evidence="4" type="ORF">NECHADRAFT_78784</name>
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        <lineage>
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            <taxon>Sordariomycetes</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
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            <authorList>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003051978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YPK3"/>
    <dbReference type="STRING" id="660122.C7YPK3"/>
    <dbReference type="GeneID" id="9668728"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78784"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78784"/>
    <dbReference type="eggNOG" id="ENOG502S7YV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070882_0_0_1"/>
    <dbReference type="InParanoid" id="C7YPK3"/>
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    <dbReference type="OrthoDB" id="9936937at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
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            <end position="95"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF25871"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEU46311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="235" mass="25690" checksum="57B64039C228DC1C" modified="2009-10-13" version="1">MEQQQSSAQRPLAGADSIRALKDDNAIFTAFDSYPWTKDKMFMSGLYAILGEPGQQNPQASLVDMAIHARVFYYSQRIGVMIDFTAYKAWLASNPDHSPPDVLPEEYHRRDGPNASPPPVLDWQKAAPKADLYIDRKAAAAQAGSEDQPNYPMGFAEMIKLLKEGKPVPGIRQIPNTIARDPSVKPVGARAVPRKPWEKDAAADPPTLPDLPKALDTEFPPVDDDVPASANVATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQ17</accession>
    <name>C7YQ17_FUSV7</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">NECHADRAFT_100020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
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                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
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                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
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                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003051614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQ17"/>
    <dbReference type="STRING" id="660122.C7YQ17"/>
    <dbReference type="GeneID" id="9668889"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100020"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100020"/>
    <dbReference type="eggNOG" id="ENOG502S5P0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039192_1_0_1"/>
    <dbReference type="InParanoid" id="C7YQ17"/>
    <dbReference type="OMA" id="TEADWRN"/>
    <dbReference type="OrthoDB" id="5397087at2759"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
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            <end position="277"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="32"/>
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            <end position="218"/>
        </location>
    </feature>
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        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEU45947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="453" mass="50627" checksum="B0EE3CAE4A25A569" modified="2009-10-13" version="1">MPKRIREPQDTGEKTQPPVRRATERSHSENQERAYIAASRRADRSIEARVQSARNASEIHKKRTGKAFRITEEIVMKEEMYEEEDDEFPRSYRLLNPHMQTANPELNARVDAYLSNKVAMSTLITATENDWRNNEINTTFDQFFPNVQSRARAASQWSTSQGFLPQTLHSPVATPRVLSVGEQHFNMQFHPVNYGHPNNGQQNNGKPNNGQQNNGQPKSRQPSSGQQNNGQQNNERHLSTASLPVSPTEDRNNVPMSPPALTPGSMSHPETPRSRHGSAFVATQSQSYNTRGFDSESSSFTSQLPPEARMFLGGVGLGNPYGPMYHEPQMWPAQSFSLDAGADPTQFFGYTPDTKPLKEGETTEASGGEQYPDPFTIMNWNGQNESDSPAQNVSWNNQGDSQRESDSPAKKTGLNNQGDNQGDKQDESDSQAKNVLEEWETYIDDSAFSSSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQ75</accession>
    <name>C7YQ75_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA replication regulator Sld3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_38515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051684.1">
        <property type="nucleotide sequence ID" value="XM_003051638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQ75"/>
    <dbReference type="STRING" id="660122.C7YQ75"/>
    <dbReference type="GeneID" id="9668913"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_38515"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_38515"/>
    <dbReference type="eggNOG" id="ENOG502S01X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006240_0_0_1"/>
    <dbReference type="InParanoid" id="C7YQ75"/>
    <dbReference type="OMA" id="IYEQLGW"/>
    <dbReference type="OrthoDB" id="5395343at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013948">
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    </dbReference>
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        <property type="entry name" value="Sld3"/>
    </dbReference>
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        <property type="entry name" value="DNA REPLICATION REGULATOR SLD3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA REPLICATION REGULATOR SLD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08639">
        <property type="entry name" value="Sld3_STD"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="303"/>
            <end position="760"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
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            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
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            <end position="340"/>
        </location>
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            <end position="436"/>
        </location>
    </feature>
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            <begin position="513"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="719"/>
            <end position="838"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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            <end position="40"/>
        </location>
    </feature>
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        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
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        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
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        <location>
            <begin position="541"/>
            <end position="552"/>
        </location>
    </feature>
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        <location>
            <begin position="553"/>
            <end position="571"/>
        </location>
    </feature>
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        <location>
            <begin position="721"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="831"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08639"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEU45971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="856" mass="94770" checksum="4CDB82BD716808EC" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQI6</accession>
    <name>C7YQI6_FUSV7</name>
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        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">NECHADRAFT_79118</name>
    </gene>
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        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQI6"/>
    <dbReference type="GeneID" id="9672655"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79118"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79118"/>
    <dbReference type="eggNOG" id="ENOG502S7P4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2146523_0_0_1"/>
    <dbReference type="InParanoid" id="C7YQI6"/>
    <dbReference type="OMA" id="LCYINGT"/>
    <dbReference type="OrthoDB" id="2122304at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BLR7753 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEU46029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="112" mass="12129" checksum="6271840852E11042" modified="2009-10-13" version="1">MSKRVTSSTNPQVSLPLSANLPSNTRQKKQLILRAKAATENGFETIGYFAAGVAAANHAGVRAPALNALSFGYVACRAVYNVAYVWLQADRRLCWVRSVVWTVGIGLITTFN</sequence>
</entry>
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    <accession>C7YQN8</accession>
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        <recommendedName>
            <fullName evidence="3">LRR-containing protein second PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">NECHADRAFT_68500</name>
    </gene>
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        <lineage>
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            <taxon>Sordariomycetes</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
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                <person name="Salamov A."/>
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                <person name="Lindquist E."/>
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                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
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                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003052168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQN8"/>
    <dbReference type="STRING" id="660122.C7YQN8"/>
    <dbReference type="GeneID" id="9673592"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_68500"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_68500"/>
    <dbReference type="eggNOG" id="ENOG502RSHR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003789_1_0_1"/>
    <dbReference type="InParanoid" id="C7YQN8"/>
    <dbReference type="OMA" id="CEDAPCF"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057334">
        <property type="entry name" value="PH_2nd_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25353">
        <property type="entry name" value="PH_2nd_LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="LRR-containing protein second PH" evidence="3">
        <location>
            <begin position="267"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1116"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1123"/>
            <end position="1132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU46501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1209" mass="133649" checksum="5BDC74B1B8568A1F" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7YR75</accession>
    <name>C7YR75_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WKF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_93506</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050744.1">
        <property type="nucleotide sequence ID" value="XM_003050698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YR75"/>
    <dbReference type="STRING" id="660122.C7YR75"/>
    <dbReference type="GeneID" id="9666513"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_93506"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_93506"/>
    <dbReference type="eggNOG" id="KOG4829">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045013_1_0_1"/>
    <dbReference type="InParanoid" id="C7YR75"/>
    <dbReference type="OMA" id="NAFRECL"/>
    <dbReference type="OrthoDB" id="10261563at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019327">
        <property type="entry name" value="WKF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22306">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22306:SF2">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10180">
        <property type="entry name" value="WKF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WKF" evidence="2">
        <location>
            <begin position="122"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU45031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="387" mass="42841" checksum="32BAB65FE80F331A" modified="2009-10-13" version="1">MHQHTTPLYNYVQVPAWKRLGLKLKQPSAASEPASTQSFGHPSTSTTHSATKRKLDAPQPSNSSQRQKSVTFADTPSRSTNAGVTSKFNTPTKTPKQSKAKSKGPAKKEKPQAPTDLKPALEHLRLWKTARDSWKFNKIHQNNLVKHVFDADKFPAADIDAFYDYIQDLKGFGRMRLRDTAREIRDQDQSEGAKAFPEGTKDLEATQQRYETVLAKYLENQPVGTKRKGFTEVDYLSDSDDDAIIIQRLVKRMRAELIIEELSDSDDTETSTTSSQTITASDNNATTTTDADKRVKLNDGSGKRKRKLRVNLDDSDTSSSESESDSDSESDSDTSSSGSSSSESESENEGPARPYRRPGEEDSSDSSSSSDDTSSEEDSSEDESDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRU0</accession>
    <name>C7YRU0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_40718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050845.1">
        <property type="nucleotide sequence ID" value="XM_003050799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YRU0"/>
    <dbReference type="STRING" id="660122.C7YRU0"/>
    <dbReference type="GeneID" id="9666013"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_40718"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_40718"/>
    <dbReference type="eggNOG" id="ENOG502RZT7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044590_1_0_1"/>
    <dbReference type="InParanoid" id="C7YRU0"/>
    <dbReference type="OMA" id="IAWRTAM"/>
    <dbReference type="OrthoDB" id="2135488at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052350">
        <property type="entry name" value="Metallo-dep_Lactonases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43569">
        <property type="entry name" value="AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43569:SF2">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="124"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU45132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="346" mass="38694" checksum="ED1B972663C5FB96" modified="2009-10-13" version="1">MADDQLILPIIDSHIHLYPSSEVDSLAWCTPENPLNGQRSVDEYREATASAPSLLGFIFVETDRKNDLESGAADGSGWEGPLAEVSWIKRVALGQPRDGEGHSADDAKLCLGIVPWAPLPSGVEVMERYLDRVKEEAGDAWSKVKGFRYLVQDKPHGTMLEENFIESVKLLGRRGFVFDVGVDQHRRGKKQLEELVEFVDRVHDGVPEEEKVTLVLNHLGKPDFTVINITSDPSFHAWRTAMYTLSKDPQTYIKLSGGFSEMPDSLKNQDPNHIFEATLGWLGIVLATFGPSRIMFGSDWPVCTVGTEDAWPRWRSVVERMCWMATLGDEERAMIFGGTAKKAYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7YS53</accession>
    <name>C7YS53_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="3">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Nuclear thiol peroxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NECHADRAFT_8856</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="3"/>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050901.1">
        <property type="nucleotide sequence ID" value="XM_003050855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YS53"/>
    <dbReference type="FunCoup" id="C7YS53">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YS53"/>
    <dbReference type="GeneID" id="9666144"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_8856"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_8856"/>
    <dbReference type="eggNOG" id="KOG0855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_2_0_1"/>
    <dbReference type="InParanoid" id="C7YS53"/>
    <dbReference type="OMA" id="QACNFTS"/>
    <dbReference type="OrthoDB" id="338622at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03017">
        <property type="entry name" value="PRX_BCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000157">
        <property type="entry name" value="DOT5p Nuclear thiol peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050924">
        <property type="entry name" value="Peroxiredoxin_BCP/PrxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801:SF23">
        <property type="entry name" value="PEROXIREDOXIN DOT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="14">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU45188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="146" mass="15464" checksum="AA287C1DC0320366" modified="2009-10-13" version="1" fragment="single">VGDVVDLDGFGGEIETNDGEKTTLKALVDESKAGVVLFTYPKASTPGCTKQVCFFRDSYEPLTAGGLAIYGLSTDSPKANTTFKDKQKLPYPLLCDPKATLIGAIGLKKSPKGTQRGVFVIDKEGKVLVAEPGSPQGTVDRVKKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7YS81</accession>
    <name>C7YS81_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_69631</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051303.1">
        <property type="nucleotide sequence ID" value="XM_003051257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YS81"/>
    <dbReference type="STRING" id="660122.C7YS81"/>
    <dbReference type="GeneID" id="9668150"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_69631"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_69631"/>
    <dbReference type="eggNOG" id="ENOG502SXC3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_715813_0_0_1"/>
    <dbReference type="InParanoid" id="C7YS81"/>
    <dbReference type="OMA" id="GRAMGCD"/>
    <dbReference type="OrthoDB" id="4866377at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988624" description="Extracellular membrane protein CFEM domain-containing protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU45590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="40415" checksum="81E6047FC67AE106" modified="2009-10-13" version="1">MSLLGLWLYLFPLALSLDFESVTISRDLGNVGHTCISKCLYYTIISDMGKAMGCDDPYDNNCYCATASASASLADAWMSQCATKTCSAGDRSRDLSSMQSIYASYCMGAGFTQPGATNWYSPAEATEEPQSPSGEDDDDSTNAEPSKTVDSGSVETTTRLTIVTQTTEGGAGPSKSRVTVEATSTYYVNPDGSAAQINLSDSSDNSAVKIGVGVAVPVVAIAAIGLFAWWFIRRRKQRQAQTLPTTQPVTETTAGGGAGIAPERKDTIQRKPIGATAVSPVSSMSHTNELSGVGVQREVSGREVHPFPAVTPSPPVQVPGQHEMTGDGWRPNLEMDGRDARVEMSGEARPPELPGQTSSPPPVYTAHETTQRWELPDNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSF0</accession>
    <name>C7YSF0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome c oxidase assembly protein COX16, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cytochrome c oxidase assembly protein cox16, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_41129</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the COX16 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050951.1">
        <property type="nucleotide sequence ID" value="XM_003050905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSF0"/>
    <dbReference type="FunCoup" id="C7YSF0">
        <property type="interactions" value="143"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YSF0"/>
    <dbReference type="GeneID" id="9666194"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_41129"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_41129"/>
    <dbReference type="eggNOG" id="ENOG502S9GT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131611_2_0_1"/>
    <dbReference type="InParanoid" id="C7YSF0"/>
    <dbReference type="OMA" id="VNMKDEY"/>
    <dbReference type="OrthoDB" id="5516033at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020164">
        <property type="entry name" value="Cyt_c_Oxase_assmbl_COX16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130:SF14">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX16 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130">
        <property type="entry name" value="MITOCHONDRIAL OUTER MEMBRANE PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14138">
        <property type="entry name" value="COX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU45238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="116" mass="13731" checksum="0459EF17898F3D1B" modified="2009-10-13" version="1">MPTFQSKKFRSAADMNKIGMRYRTVMNKHPFLMFGLPFMAVIVAGSFVLTPATAVRYERHDRKVRQMTKDEELNVRRSARKVDMKEEYYRLAGRDLDNWEQKRVERLKGENDGILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSJ3</accession>
    <name>C7YSJ3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_80756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051362.1">
        <property type="nucleotide sequence ID" value="XM_003051316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSJ3"/>
    <dbReference type="GeneID" id="9666212"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_80756"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_80756"/>
    <dbReference type="eggNOG" id="ENOG502QTB6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026024_2_1_1"/>
    <dbReference type="InParanoid" id="C7YSJ3"/>
    <dbReference type="OMA" id="LADWWGL"/>
    <dbReference type="OrthoDB" id="2956246at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU45649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="401" mass="43902" checksum="057E992856FC4325" modified="2009-10-13" version="1">MFHLPILLKTQHTLTSLPSPHSPEPHSQSLQKNNGGKSNLNIKNSHSHNQPRSLIPSWTTTPLPDIVLSASGLLALADLRTISRRTALVGGASWVDSLVLAPGLHYQQACDDFEREAPIGLVALPVEAFNGVRYAVKNSITASYLVALCSQSPEGIVTLDVGLDMPWRAVKAFKKLFKKRKVEDEEDENEDDDDWDVLPDVDWLSHLLYLVSPLLTVSSLTFMILFEDWWGLAILLTLITSRILNVWAIKHRTQSPGHTPHDHRVTEYIVDLGGGHAVRLRGPDADLQALVTHAWLRAQSHIDGYLEAIAKLLVYLTAALGGNMTQAGSIVLVGLLLISAALLGLSNAHARGIRVHGRYALPETEKTKMRIISSRTSRGSSTAMREVDTASAPRNRVAGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSW2</accession>
    <name>C7YSW2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit WBP1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_61480</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DDOST 48 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051017.1">
        <property type="nucleotide sequence ID" value="XM_003050971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSW2"/>
    <dbReference type="FunCoup" id="C7YSW2">
        <property type="interactions" value="1043"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YSW2"/>
    <dbReference type="GeneID" id="9668432"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_61480"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_61480"/>
    <dbReference type="eggNOG" id="KOG2754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031804_1_0_1"/>
    <dbReference type="InParanoid" id="C7YSW2"/>
    <dbReference type="OMA" id="AHDEYPR"/>
    <dbReference type="OrthoDB" id="29105at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005013">
        <property type="entry name" value="DDOST_48_kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055459">
        <property type="entry name" value="OST48_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055457">
        <property type="entry name" value="OST48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23358">
        <property type="entry name" value="OST48_MD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03345">
        <property type="entry name" value="OST48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005125771" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1" evidence="8">
        <location>
            <begin position="19"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 N-terminal" evidence="9">
        <location>
            <begin position="25"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 middle" evidence="10">
        <location>
            <begin position="299"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU45304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="458" mass="50741" checksum="558C0C748F40AEE4" modified="2009-10-13" version="1">MRSLLSLVLLLFAALVSAAGTAGNRLLVVLDAVEEKEAYSTFFADLNERGYQITYESPKNSALSLFRLGERNYDHLVFLPTKVKGLGPNLTPNIILDFINAGGNILLTMSSTHAVPTSLVSVLAELDIALPVERTGKIVDHFNFDTISAAESHDVLVLDAPRNVRPGLKDYFEIPGALLAVSNAVGHTLGSGPLLTPILRAPPTAYSYNPKEQAETVDPDELFAAGKQLALVSTMQARNSARFTIIGSAEMLQDKTFDTKVSRKGGKALYPSNREFITSLAGWTFKELGVLRVNKIEHHLVGDNETNPEIYRIKNDVTYSISISEYAWRSWMPFELPPGDSLQLEFSMLSPFHRLDLKATHVDDHATVFSTNFTLPDQHGIFNFKVNYKRPFLTNVEEKNTVSVRHMAHDEWPRSYVISGAWPWLTGIGATVTGFLAFSIIWVYSQPVATLEKGKKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSZ3</accession>
    <name>C7YSZ3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_93930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051033.1">
        <property type="nucleotide sequence ID" value="XM_003050987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSZ3"/>
    <dbReference type="GeneID" id="9666352"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_93930"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_93930"/>
    <dbReference type="eggNOG" id="ENOG502S1A6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_1_0_1"/>
    <dbReference type="InParanoid" id="C7YSZ3"/>
    <dbReference type="OMA" id="DTPGHDH"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF5">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="5">
        <location>
            <begin position="12"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU45320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="310" mass="34145" checksum="C528CE671188FB9B" modified="2009-10-13" version="1">MCFLLEHKTDLGSEYILFDCGSRKDFWNGSPQTNKMIASNLVGMQVDYGVDEILTSSGFDLENLKSIVWSHWHWDHIGDGSKFPASVDIVVGPGFTAEFAPGWPERLNSPVLASDLRGHRIHEPEFDTSVAGFAAHDYLGDGSFYLLDVPGHALGHICGLARTTPDTFIFMGADACHFAGAFRPTPYLPLPTTHHPAAGTLSEEDADASRTSPFYKVSRVPGTVYIHGDAAQASIDKLRILDAHPGVFICLAHDAALFETLPVYNIDPDQDINDWKKAGYKERLRRDDKVIVWDEGKGFVDETKSLPGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSZ4</accession>
    <name>C7YSZ4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_41395</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051448.1">
        <property type="nucleotide sequence ID" value="XM_003051402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSZ4"/>
    <dbReference type="STRING" id="660122.C7YSZ4"/>
    <dbReference type="GeneID" id="9666353"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_41395"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_41395"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_1_1"/>
    <dbReference type="InParanoid" id="C7YSZ4"/>
    <dbReference type="OMA" id="HIASHEF"/>
    <dbReference type="OrthoDB" id="256333at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="20"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU45735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="374" mass="39898" checksum="4263398C829BCEDC" modified="2009-10-13" version="1">MVYPPEPPTTMLAAVVEKFGEPYRMRRISRPSSPQGQDILLKVLAASYCHTDAVFASGGLSQTLPRIGCHEFAGKVLEVGPDVPKARGIFAGLHVGVPGRAYHPCGTCYECQNTGSDEIGYSPYCPLAGNLGLTQDGGFQKFCLVDSRQVAPLPEGLSPLQAAPLMCAGLTIWSALRHAAVQRASTVGILGAGGGLGHLGVQFAARLGKRVLAIDAKDAALAHLKQVKHSLGSAGTSVHVVDACTLNVDETKGIWEESPAKLPTDIGLDAVILLPESQKAFDLGVQLLRNHGTMIVLSFPKEKLSVSAHDLVFRDIRLVGSLVGRNTQLREMLDFVMKNGVKASVKTYPFEQLNELARDSKQGVSGKLIIDMTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7YTN7</accession>
    <name>C7YTN7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="7">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_49344</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="7"/>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049990.1">
        <property type="nucleotide sequence ID" value="XM_003049944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YTN7"/>
    <dbReference type="FunCoup" id="C7YTN7">
        <property type="interactions" value="177"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YTN7"/>
    <dbReference type="GeneID" id="9675151"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_49344"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_49344"/>
    <dbReference type="eggNOG" id="KOG0787">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023861_0_0_1"/>
    <dbReference type="InParanoid" id="C7YTN7"/>
    <dbReference type="OMA" id="ICEAQEH"/>
    <dbReference type="OrthoDB" id="407390at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF25">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase N-terminal" evidence="9">
        <location>
            <begin position="57"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="8">
        <location>
            <begin position="271"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU44277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="450" mass="50910" checksum="32E95D79C7901EE4" modified="2009-10-13" version="1">MPSIALRQSRRCRLTHPGALFRTSHALFSTAHARAPNNSSWRPVAILDEWVAKEARPISLRQLMVFGRSLTESRLISSANYVRTELPIRIAHRLRDMQRLPWVVVTNPHMKAVYDLYYNAFDTFRKIKEVKTLEDNDKMCDLISQNLKSHLTVIPKLAMGILECGGLMDPNDLDKFMNTILRSRISRRVIAEQHLSLTEAYNSPNFSPGAKLSESDFIGEVFIKCYAKDVIERCSKAVRALARTTNGPGVQIPEIKVEGYLDASFPYILSHLEYIIGELLRNSVQAVIDRHQQIHADPNSVKPHPVEITICENHQHVIIRICDRGGGIPRVELPYLWSFTKGPQSQRRLENLAQVPKMAATMQELHVEEELGRADLKAPPYQSSLSSLTSRPPNLRLGMGLPLSRVYAEYWAGSLDLHSLEGYGVDVFLQISRLGNKNEQLTTRASMDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7YUU0</accession>
    <name>C7YUU0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_49089</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050577.1">
        <property type="nucleotide sequence ID" value="XM_003050531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YUU0"/>
    <dbReference type="STRING" id="660122.C7YUU0"/>
    <dbReference type="GeneID" id="9674967"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_49089"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_49089"/>
    <dbReference type="eggNOG" id="KOG3923">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034311_2_0_1"/>
    <dbReference type="InParanoid" id="C7YUU0"/>
    <dbReference type="OMA" id="EYDTWVV"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF26">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_5G13940)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="16"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU44864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="382" mass="41779" checksum="F5FDEBC8528475FF" modified="2009-10-13" version="1">MKKLKFPYSVLTHNRAGIIGLTCALSIQSKLAEQHLDHLYLVMIVSRDFPTCTPGAPTSHAVDYASVWAGAHVRPIPASTPQLAREAAWLKQTVQHLRGQVEREPWIGITPVTGVEYLEATDEAYETWNGGSFEADTGLTGFHELPTSFLPPGVVLGFEYQTFCLNAPVYYTGLLRKFLLQGGHTLKRNLASEWEEFSVAPNVAAVINASGVGFGDPKCFPTRGQIVLTNLTGFSKTIIRQCKDGSWSFVIPRFFDGGTIIGGTKEPNNWETKPHFDTREELIEAAKGLDPGLAVSLEGYKGGKGPHVIADVVGRRPTRDGGMRLQVERKSFLRENGRAVVHAYGAGGRGYELSWGVAQEVTSLVMEELNISNGAKIRPSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVI6</accession>
    <name>C7YVI6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_29805</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU43801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049514.1">
        <property type="nucleotide sequence ID" value="XM_003049468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVI6"/>
    <dbReference type="FunCoup" id="C7YVI6">
        <property type="interactions" value="262"/>
    </dbReference>
    <dbReference type="GeneID" id="9677290"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_29805"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_29805"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="InParanoid" id="C7YVI6"/>
    <dbReference type="OMA" id="TQLWCTV"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU43801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="324" mass="35098" checksum="6326AF2D6C1FED8D" modified="2009-10-13" version="1">MEKHHCWFGSASFDPDVDIPDLSGKVCLVTGSNTGLGLATLKALAKHNPAKIYLAARSRSKAEAARLEIQASSPAAEKANIDLLDLDVSSFHSIKAAAERVNKEVERLDILQLNAGIAMIPPATTAEGYEIQFGTNYLGHVLFTQLLMPKLLATAAMPGADVRIVSMSSVGHKPFAPSSGIIFDELKSDMGNHGGHELYGQAMLAKALFAYELAKRFPQITSTSLHPGTVKSGVWGGNKDVNWLIFNVLVKPAVALTGVTNEEGCKTQLWCSFSKDVKNGHYYEPIGKEGKESKLARDDELSAKLWEWTEKELQAHGAPGWKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWX1</accession>
    <name>C7YWX1_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_101116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049442.1">
        <property type="nucleotide sequence ID" value="XM_003049396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWX1"/>
    <dbReference type="GeneID" id="9666105"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101116"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101116"/>
    <dbReference type="eggNOG" id="ENOG502SF70">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166278_0_0_1"/>
    <dbReference type="InParanoid" id="C7YWX1"/>
    <dbReference type="OMA" id="EQDNNQM"/>
    <dbReference type="OrthoDB" id="2873061at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587:SF4">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU43729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="127" mass="14492" checksum="7465DF0A38A7920B" modified="2009-10-13" version="1">MPPAPTQDVEQRDGLSDDSQDTGAKYEEEEAPVKKEKTRKKTKKNKVERRKRRSMFTDDEMDMGMTQGNWGMGQQQQPQQQQMQQQQPQQGGGGKSDALSLHLELNLEIEIQLKARIHGDLTLTLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7YX48</accession>
    <name>C7YX48_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ASST-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_95070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049482.1">
        <property type="nucleotide sequence ID" value="XM_003049436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YX48"/>
    <dbReference type="GeneID" id="9676913"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95070"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95070"/>
    <dbReference type="eggNOG" id="ENOG502QTSQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018249_1_0_1"/>
    <dbReference type="InParanoid" id="C7YX48"/>
    <dbReference type="OMA" id="GWVANFR"/>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF9">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002986616" description="ASST-domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU43769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="59239" checksum="F39A5380A8717ED7" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXL2</accession>
    <name>C7YXL2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_82568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049318.1">
        <property type="nucleotide sequence ID" value="XM_003049272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXL2"/>
    <dbReference type="GeneID" id="9676969"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82568"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82568"/>
    <dbReference type="eggNOG" id="ENOG502RK1K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048615_0_0_1"/>
    <dbReference type="InParanoid" id="C7YXL2"/>
    <dbReference type="OMA" id="HETTRNK"/>
    <dbReference type="OrthoDB" id="4367324at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU43605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="411" mass="48026" checksum="30E393CCF372DE56" modified="2009-10-13" version="1">MTGTNPATSILELLTYPNPTVSHRPPKRKTNSRNQKWHAPKQIKKWDEFHDFNVFRASFGGRLLEEARREGRHFAAYPDIDYETNCIERNEDDTRELYAVWNKKIVTAALRPIRQEFHSAIWSKGDPPSEDELSEPPPRPEKQRQQPPRKCSIGARTPQMQSLQGLRPDSGTALRNTSPTDGDPDPATYRLERFPKEYKPAEKWKSKWMAQVPLINESGEWERGRLSHDLAWPIKQAYTYCIQNMCRYGCILTCHEAFIFRVRPRSIKSVDGPQETSVLKRQLIRDGLMEYISIPWANHRQGDLESHETWTINLALWFMHILVGNKYEVCWRYDRLLDETLAALRPSQDEPLTHEDQDEDEDDDESSDSDASDETVPFDESLFTPLRKRKRDEDVEEGINHSFSKRQFLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXS7</accession>
    <name>C7YXS7_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_82634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049351.1">
        <property type="nucleotide sequence ID" value="XM_003049305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXS7"/>
    <dbReference type="GeneID" id="9666407"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82634"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82634"/>
    <dbReference type="HOGENOM" id="CLU_1503834_0_0_1"/>
    <dbReference type="InParanoid" id="C7YXS7"/>
    <dbReference type="OrthoDB" id="4982160at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU43638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="179" mass="20017" checksum="0BA9482B6B19D41C" modified="2009-10-13" version="1">MSFVLQLIQNLPGLTILKHDQGMRFVALLGASCRVSSPDKGAQYRVTFPDDNVGEIAIFNDGEEEIQLHALFYCQEIVLDSDLTVEWTKAWLRCAKIGNAIKDIEARVAIGCDTLPAVNAKGPDTVPNDRRTWEWRFPLEEEQDHVRTCTGDAIAVRIGVKLAPKEGIHIRSLKLGYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXT7</accession>
    <name>C7YXT7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_62410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049357.1">
        <property type="nucleotide sequence ID" value="XM_003049311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXT7"/>
    <dbReference type="GeneID" id="9677005"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_62410"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_62410"/>
    <dbReference type="eggNOG" id="ENOG502SJHI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039077_0_0_1"/>
    <dbReference type="InParanoid" id="C7YXT7"/>
    <dbReference type="OMA" id="FVDWTWI"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988775" description="Peptidase A1 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="51"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU43644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="439" mass="47699" checksum="FF3EB574341407FB" modified="2009-10-13" version="1">MMHTFHHLAVLLIGSLPASASTLPHPDGYRHVNASCSKSVAVPAVWNGFGYLFNITVGTPPQELTMLSDWTWMSLFVRSGRCLNQYDPSLCLGTSGQTWFDEKVSTSFANTTLPQLSWPLTAFAPNFTVDYGTDDVCIGNVCSAGTVLQVSDFPYPGEGIPKVPFGGIFGMAPVTAGLNETFHPANYQAWKAGRLGSLVGWNSCAALASSDPCLGGEAKLVFGGTDSSLYDNDTLRIYEIQNPDWLSDAFYPLTPPRENYWTTPLTGSWILGNSKEESRNFADPFSGSNGSNVTPLAVLDEGSEGLGAPLSLNAYNWLVDQVRGTVASNDTVEEILAQGSSGFNTAEQDWYTVSCDDMDSYPELVYELNGHTNYTVPPQDYVTKIGDSSTCYLNINVWKYGRTEDGNAKVALLGLAFLKRLYVVLDFETQSFGLAPLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7YY96</accession>
    <name>C7YY96_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_46630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048862.1">
        <property type="nucleotide sequence ID" value="XM_003048816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YY96"/>
    <dbReference type="GeneID" id="9665784"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_46630"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_46630"/>
    <dbReference type="eggNOG" id="KOG3947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041441_2_0_1"/>
    <dbReference type="InParanoid" id="C7YY96"/>
    <dbReference type="OMA" id="SRPRMHC"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF0">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU43149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="327" mass="36611" checksum="CC2B1C50416BC3C8" modified="2009-10-13" version="1">MSPLIKTRFLILSDTHGLQFQEDRKPHISADVVIHCGDITCDSKLHDFKQAIDLLKEIDAPLKIVIAGNHDFSLDDLAFKEKITEASRLAQEDLEESIKIEYGDYGDARRLFDGHEDIVFLEEGSHQFPLDNGALLRVYASPYTPTTGNSSDWGFQYSGAHEFAIEKGTDIVVTHGPPHGIMDMTTERQRIGCPQLFGAVARAQPKLHCFGHVHDSWGAKLVAWRPTISDQPSHFSDIDNGKSVVIESLSRLKGSKFESAEDREAREDAVERYKSQWYCHTSHCGGDNRPLGLGETLFVNAAVMGDGELSQYPWLVDIELEPYRGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYU5</accession>
    <name>C7YYU5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_83807</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048773.1">
        <property type="nucleotide sequence ID" value="XM_003048727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYU5"/>
    <dbReference type="STRING" id="660122.C7YYU5"/>
    <dbReference type="GeneID" id="9665620"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83807"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83807"/>
    <dbReference type="eggNOG" id="ENOG502SBS0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010066_0_0_1"/>
    <dbReference type="InParanoid" id="C7YYU5"/>
    <dbReference type="OMA" id="CETCQAS"/>
    <dbReference type="OrthoDB" id="106784at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16620">
        <property type="entry name" value="vRING-HC-C4C4_RBBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032922">
        <property type="entry name" value="SON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46528">
        <property type="entry name" value="PROTEIN SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46528:SF1">
        <property type="entry name" value="PROTEIN SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="27"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="396"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="479"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
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        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="560"/>
            <end position="598"/>
        </location>
    </feature>
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        <location>
            <begin position="607"/>
            <end position="626"/>
        </location>
    </feature>
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        <location>
            <begin position="657"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="688"/>
            <end position="710"/>
        </location>
    </feature>
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        <location>
            <begin position="719"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="810"/>
            <end position="832"/>
        </location>
    </feature>
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        <location>
            <begin position="863"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="886"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU43060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="901" mass="99412" checksum="F2FD543FAF997369" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZC9</accession>
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            <fullName evidence="4">HbrB-like protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">NECHADRAFT_47711</name>
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        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
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        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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            <taxon>Fusarium vanettenii</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048294.1">
        <property type="nucleotide sequence ID" value="XM_003048248.1"/>
    </dbReference>
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    <dbReference type="STRING" id="660122.C7YZC9"/>
    <dbReference type="GeneID" id="9667745"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_47711"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_47711"/>
    <dbReference type="eggNOG" id="ENOG502RZ40">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005193_1_0_1"/>
    <dbReference type="InParanoid" id="C7YZC9"/>
    <dbReference type="OMA" id="VELWLFT"/>
    <dbReference type="OrthoDB" id="2290221at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013745">
        <property type="entry name" value="Bit61/PRR5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428:SF2">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="HbrB"/>
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    </dbReference>
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    </feature>
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            <end position="67"/>
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            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
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            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
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        <location>
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        </location>
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            <end position="690"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="843" mass="89714" checksum="714E8543797A28B1" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZH2</accession>
    <name>C7YZH2_FUSV7</name>
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        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="1" type="ORF">NECHADRAFT_84029</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048315.1">
        <property type="nucleotide sequence ID" value="XM_003048269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZH2"/>
    <dbReference type="GeneID" id="9667766"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84029"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84029"/>
    <dbReference type="eggNOG" id="ENOG502RMKV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037442_1_0_1"/>
    <dbReference type="InParanoid" id="C7YZH2"/>
    <dbReference type="OMA" id="RISEYWA"/>
    <dbReference type="OrthoDB" id="5033794at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU42602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="52868" checksum="F40E10AE17611828" modified="2009-10-13" version="1">MTHPADRVFHTLELAQHIVHHLQEKDLFIALGITKALWKSREPVSAWREYIRRFGYADSLIDQYTDRYHPRDIYLRICRSADAINRGTNPKCKRIDLRDDDPDDSLVCMGKQDVHYLSRQLVEDEIDIYTLDHRGLKLLHKGKNMRLMSCFDNSSRLLGNEDDQIVARNIKDWSLSGSFGPYRPLQQWWTQDRHVLTFHVIEQGETSKTIFEVWDAHGVKRGELVHPDGCTFHDLEKPGENLMATGSERHIRVWDLDTLKCVYEYDAPEDSPGAILDLHQNIVFYKPHIGIWFTDFWTTDGSPVTRPRAELVTRANSSWCKFSDGTMVTYPWEMTLCDPEGGELYAVYYSSNLEEPYELDAGILLDRFFFTVIKIIDYEEADTVPKPAELKIYAKDGEELGSKILRKGGRTHRWFVDIFGRLVFVYQDSNERLEELEVVDFCRWAKVATRRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z076</accession>
    <name>C7Z076_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carbonic anhydrase</fullName>
            <ecNumber evidence="2">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_63216</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048635.1">
        <property type="nucleotide sequence ID" value="XM_003048589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z076"/>
    <dbReference type="STRING" id="660122.C7Z076"/>
    <dbReference type="GeneID" id="9667528"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_63216"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_63216"/>
    <dbReference type="eggNOG" id="KOG0382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039326_0_1_1"/>
    <dbReference type="InParanoid" id="C7Z076"/>
    <dbReference type="OMA" id="GHTIQAN"/>
    <dbReference type="OrthoDB" id="429145at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03124">
        <property type="entry name" value="alpha_CA_prokaryotic_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041891">
        <property type="entry name" value="Alpha_CA_prokaryot-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF265">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988702" description="carbonic anhydrase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="8">
        <location>
            <begin position="38"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU42922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="311" mass="33203" checksum="E7525F1531F29018" modified="2009-10-13" version="1">MPAWSSLFTLLAASAPQVLASCAYGTHLHPRAEAFEEPKFGYNGIKGPVNWYSLDPAANVMCATGKSQSPINMAKGSFNLIPASEMTLEIPDFTEGAEFENLGTTVEVIAEEAGGGSLEIGEKSYELKQFHFHLPSEHLDNGTSMAMEMHMVWQTAEEEIAVIGVYIDLDDGAAAAASSAKSHHARGRAKRAALEPRQSAATASTVLETVLGSVDKIATPGATTHTEPLAMSELVKLLTSGSFQSYAGSLTTPPCSEGVRWLVSNKKVSIKTSTYLKARSVIGFNARYPQNAPGEENLLQIAADAEDEHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0F1</accession>
    <name>C7Z0F1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_79871</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047903.1">
        <property type="nucleotide sequence ID" value="XM_003047857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0F1"/>
    <dbReference type="GeneID" id="9667257"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79871"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79871"/>
    <dbReference type="eggNOG" id="ENOG502SX0U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_672842_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z0F1"/>
    <dbReference type="OrthoDB" id="5072820at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="384"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU42190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="409" mass="45828" checksum="FFE87930BDA8231D" modified="2009-10-13" version="1">MPRKAAQPPPPSIVAPEEEGGLATQVAEKVLKSLEPILENRIGTVQQSVAVVAKLVDMNLNQSDDPKHFLQRNPDIRYTLDAPSDLNRVKALTMSEIMCLLQRAGEPFNQIIRVKHSGQELRFTSKSESAEIRIRAEAWQISTHLGLSVNCGVIPKPYFVCADNVSNELFPKPRDLKDEWSEENQVDINNAFWARKNLILVLFELEHAKKLISDGIFFGDTHFSHVRPFELQSVPKFCYKCYKPNHLRKECQARDFRCGRCAGMHDTQGCDNPAIRCPNCGKEHEAWFPQCSNRQVQSMRALCKEWESQGPSWATMSPREELNGWLKQMTSPSPGPSQSQPVEPKTAPKKGKKKAKASADAPKDQDRRVTRSATAKAAASSTESGDRGQTEGEQRVGKPKGRKNKNSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z113</accession>
    <name>C7Z113_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LrgB-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_100400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048001.1">
        <property type="nucleotide sequence ID" value="XM_003047955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z113"/>
    <dbReference type="GeneID" id="9667371"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100400"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100400"/>
    <dbReference type="eggNOG" id="ENOG502QQ63">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024337_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z113"/>
    <dbReference type="OMA" id="LRWMNLF"/>
    <dbReference type="OrthoDB" id="2502820at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007300">
        <property type="entry name" value="CidB/LrgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005538">
        <property type="entry name" value="LrgA/CidA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30249:SF0">
        <property type="entry name" value="PLASTIDAL GLYCOLATE_GLYCERATE TRANSLOCATOR 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30249">
        <property type="entry name" value="PUTATIVE SEROTONIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03788">
        <property type="entry name" value="LrgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04172">
        <property type="entry name" value="LrgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU42288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="551" mass="59552" checksum="597095C47D00E574" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z171</accession>
    <name>C7Z171_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DSBA-like thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_80134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048025.1">
        <property type="nucleotide sequence ID" value="XM_003047979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z171"/>
    <dbReference type="STRING" id="660122.C7Z171"/>
    <dbReference type="GeneID" id="9672010"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_80134"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_80134"/>
    <dbReference type="eggNOG" id="ENOG502QTH7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069253_0_1_1"/>
    <dbReference type="InParanoid" id="C7Z171"/>
    <dbReference type="OMA" id="IRWHAFQ"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03024">
        <property type="entry name" value="DsbA_FrnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887:SF41">
        <property type="entry name" value="THIOREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="9"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="221" mass="24595" checksum="A59A69831954301B" modified="2009-10-13" version="1">MPTISITAISDPVCPWCYIGAIRLTRAISLYRKTVSSSDVVTTSWHAYQLDPHTKTQPMLEKMASKVGEEKVPEFKARLGDIGKREGLIFDFGGTIGNTRDAHRLEKLAKTKDEVDLQTRVALEVMKMYFEEGSNITSIDDLVKAAGRAGIDEGEARAWLESDNGGEEVDAEVLEMQKLGVRGVPRYIINGKFMIDGAEDVGIFLEQMVLAREEALRENQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1N7</accession>
    <name>C7Z1N7_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_85862</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU42032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047745.1">
        <property type="nucleotide sequence ID" value="XM_003047699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1N7"/>
    <dbReference type="STRING" id="660122.C7Z1N7"/>
    <dbReference type="GeneID" id="9671530"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85862"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85862"/>
    <dbReference type="eggNOG" id="ENOG502T4E7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091427_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z1N7"/>
    <dbReference type="OMA" id="PQLHSDC"/>
    <dbReference type="OrthoDB" id="5414836at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.510">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF33">
        <property type="entry name" value="MEMBRANE PROTEIN WSC4, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="104"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="194"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="130"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU42032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="266" mass="28868" checksum="41F4D8E3716DFA94" modified="2009-10-13" version="1">MAGDILTLVRRQSTPVQCYNCEYAYQYARLAGRTEALCEDDGFYDLYQTCANCIEDETDTDNVREYVEPKLGRFVDYCASFTSLTNWATMGTASAALATASATLATTEEDEQRSATEAASTDDADDSTSRNVPAATSNSESDQLDPPTSSSPSEANDNSGKSQAWIAGPVVGAIVAVLILAGVGFWWYRRRKRAPKAPPSPQENQETAQFDKPQLHSECIPRPNPGQVVTTLPADQGHAHSYSYGEMPANEAPAYELSGEDRRRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z2J3</accession>
    <name>C7Z2J3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amine oxidase</fullName>
            <ecNumber evidence="11">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_72998</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="11">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="10">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10 11">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="11"/>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047386.1">
        <property type="nucleotide sequence ID" value="XM_003047340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z2J3"/>
    <dbReference type="STRING" id="660122.C7Z2J3"/>
    <dbReference type="GeneID" id="9671472"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_72998"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_72998"/>
    <dbReference type="eggNOG" id="KOG1186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011500_3_1_1"/>
    <dbReference type="InParanoid" id="C7Z2J3"/>
    <dbReference type="OMA" id="LYAGGWY"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF33">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="13">
        <location>
            <begin position="7"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="12">
        <location>
            <begin position="238"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="9">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="10">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU41673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="683" mass="76232" checksum="D839A42C83FB2AC9" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z305</accession>
    <name>C7Z305_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_97825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047462.1">
        <property type="nucleotide sequence ID" value="XM_003047416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z305"/>
    <dbReference type="GeneID" id="9675895"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_97825"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_97825"/>
    <dbReference type="eggNOG" id="ENOG502SC2M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016056_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z305"/>
    <dbReference type="OMA" id="CANHCGA"/>
    <dbReference type="OrthoDB" id="96314at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052701">
        <property type="entry name" value="GAG_Ulvan_Degrading_Sulfatases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43751">
        <property type="entry name" value="SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43751:SF3">
        <property type="entry name" value="SULFATASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="3">
        <location>
            <begin position="575"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU41749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="910" mass="103876" checksum="91AB600C1D83ED8D" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z3H9</accession>
    <name>C7Z3H9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_95210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047026.1">
        <property type="nucleotide sequence ID" value="XM_003046980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z3H9"/>
    <dbReference type="STRING" id="660122.C7Z3H9"/>
    <dbReference type="GeneID" id="9675436"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95210"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95210"/>
    <dbReference type="eggNOG" id="KOG1412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032440_1_2_1"/>
    <dbReference type="InParanoid" id="C7Z3H9"/>
    <dbReference type="OMA" id="ANHMAAH"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000066">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF20">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="29"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU41313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="404" mass="45056" checksum="5AE33C9D9689A4A5" modified="2009-10-13" version="1">MSYLDKLPPIQPDPAFSLVAAYEADTCEKKVDLCPGFYRDENAKPWILPSVVQAKERIHGNPILNHEHLPLSGHPGLIRGAQELAFGKTRDLKRVASIQTVSGTGANHIAALFLSTRLKPKTVWISNPSWINHTEIWKLAGPDVQQRFYPYFDAEKSKVDFEGMTETLRKDARKGDVVILHACAHNPTGADLTESQWKIVAKICKKIGLFAVFDMAYQGFASGNLEQDAFAITHFYDSFDMEFAIAQSFSKNFGLYSERIGVLHVVALDAKAAANTTLLLTQVSRAEITSCPSYGARIVAEILGNPILFKQWLEDLVEMSERMKRMRLSLYQGLERRKVRGSWNHLLSDIGMFSMTGLSRAQVVELREKHHIYLLPSGRLSVTGLTSNNVESVAAALHDILGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4M6</accession>
    <name>C7Z4M6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF300 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_91131</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046087.1">
        <property type="nucleotide sequence ID" value="XM_003046041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4M6"/>
    <dbReference type="FunCoup" id="C7Z4M6">
        <property type="interactions" value="611"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z4M6"/>
    <dbReference type="GeneID" id="9678468"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_91131"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_91131"/>
    <dbReference type="eggNOG" id="KOG2641">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012923_4_2_1"/>
    <dbReference type="InParanoid" id="C7Z4M6"/>
    <dbReference type="OMA" id="AFAIAHW"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="368"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="438"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="548"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="576"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU40374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="587" mass="65759" checksum="A78B851766A80452" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4Q4</accession>
    <name>C7Z4Q4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein BCP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_33359</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Involved in nuclear export, actin cytoskeleton organization and vesicular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the BCP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046102.1">
        <property type="nucleotide sequence ID" value="XM_003046056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4Q4"/>
    <dbReference type="FunCoup" id="C7Z4Q4">
        <property type="interactions" value="991"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z4Q4"/>
    <dbReference type="GeneID" id="9678481"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_33359"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_33359"/>
    <dbReference type="eggNOG" id="KOG3034">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068770_2_0_1"/>
    <dbReference type="InParanoid" id="C7Z4Q4"/>
    <dbReference type="OMA" id="VKFYRKE"/>
    <dbReference type="OrthoDB" id="27543at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025602">
        <property type="entry name" value="BCP1_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261">
        <property type="entry name" value="BRCA2 AND CDKN1A INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261:SF0">
        <property type="entry name" value="BRCA2 AND CDKN1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13862">
        <property type="entry name" value="BCCIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028983">
        <property type="entry name" value="BCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU40389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="285" mass="32085" checksum="90A9B9D0A08CD514" modified="2009-10-13" version="1">MGKKRAREEAKDVPPADVDKMDEDGSDDEDFDMVNVEFEWFNFDPEVDFHGTKTLLRQLFDVDANLFNMSALSDLVLSQPTIGSTIKVDGKANDAYALLTVLNTAVHQNKEPMNDILKYLVNKAQSNPSLAPVANVLNSGKHVGLIFSERLINMPSELAPPLYSMLVDEVEAAVEDKEPYEFSHYLILSKTYQELESKLDQENQKRKKAKEEAGVYYFHVEDEVLQKHAEAYGNFNYTKEDESVADSKRAFQEMGVKAHGHMILIEASKFPGAVKAVNEYLSAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z682</accession>
    <name>C7Z682_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_33675</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the 2nd section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the shikimate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045794.1">
        <property type="nucleotide sequence ID" value="XM_003045748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z682"/>
    <dbReference type="STRING" id="660122.C7Z682"/>
    <dbReference type="GeneID" id="9667926"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_33675"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_33675"/>
    <dbReference type="eggNOG" id="KOG0692">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008871_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z682"/>
    <dbReference type="OMA" id="AVYSMIH"/>
    <dbReference type="OrthoDB" id="4415835at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000386">
        <property type="entry name" value="Quinate repressor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090">
        <property type="entry name" value="AROM/DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090:SF27">
        <property type="entry name" value="QUINATE REPRESSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="5">
        <location>
            <begin position="546"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase" evidence="4">
        <location>
            <begin position="688"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="SDH C-terminal" evidence="6">
        <location>
            <begin position="830"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="866"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="866"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU40081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="887" mass="97996" checksum="D137C2EC38E9B96C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6S7</accession>
    <name>C7Z6S7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Uracil permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_76199</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046461.1">
        <property type="nucleotide sequence ID" value="XM_003046415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6S7"/>
    <dbReference type="FunCoup" id="C7Z6S7">
        <property type="interactions" value="632"/>
    </dbReference>
    <dbReference type="GeneID" id="9668803"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76199"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76199"/>
    <dbReference type="eggNOG" id="KOG2466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021555_2_0_1"/>
    <dbReference type="InParanoid" id="C7Z6S7"/>
    <dbReference type="OMA" id="GWNWRAV"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000001">
        <property type="entry name" value="Uracil permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012681">
        <property type="entry name" value="NCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00800">
        <property type="entry name" value="ncs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF2">
        <property type="entry name" value="ALLANTOIN PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="529"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU40748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="551" mass="61183" checksum="AF9FDDA0FD3A3AD9" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z715</accession>
    <name>C7Z715_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">10 kDa heat shock protein, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_102425</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045939.1">
        <property type="nucleotide sequence ID" value="XM_003045893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z715"/>
    <dbReference type="SMR" id="C7Z715"/>
    <dbReference type="FunCoup" id="C7Z715">
        <property type="interactions" value="815"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z715"/>
    <dbReference type="GeneID" id="9668848"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102425"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102425"/>
    <dbReference type="eggNOG" id="KOG1641">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132825_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z715"/>
    <dbReference type="OMA" id="EDFLIMR"/>
    <dbReference type="OrthoDB" id="184876at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.33.40:FF:000002">
        <property type="entry name" value="10 kDa chaperonin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772:SF0">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU40226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="11128" checksum="8F79D309924CA8C0" modified="2009-10-13" version="1">MATSIKSIRALAPLLDRVLVQRIKAEAKTASGIFLPESSVEKLNEAKVLAVGPGALDKKGNRLPMGVAVGDRVLIPQFGGSPVKAGEEEYQLFRDSEILAKINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z771</accession>
    <name>C7Z771_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_103402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045964.1">
        <property type="nucleotide sequence ID" value="XM_003045918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z771"/>
    <dbReference type="STRING" id="660122.C7Z771"/>
    <dbReference type="GeneID" id="9668873"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_103402"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_103402"/>
    <dbReference type="eggNOG" id="KOG0429">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040072_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z771"/>
    <dbReference type="OMA" id="DGIWAKR"/>
    <dbReference type="OrthoDB" id="5596422at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd23814">
        <property type="entry name" value="UEV_AKTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="12"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU40251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="332" mass="35937" checksum="07B236B0940CEE9B" modified="2009-10-13" version="1">MASVKMGGLPSLRKQQLLSEFTGLKQACPEGIFVSLTPGDATLWSGVLFVRKGPYCPAILRFQISFPDAYPQLPPLVTFSTDMFHPLITPLTTYVYSTEIEDSGTVSASDQERLPPGGFSLRHGFPDWFGRGRRSMIEARRTSGQQTSSPGPTGSISSATTTPASSAGKPSYMRTGKKSVSAYEVLHYIRSTFDDEEVLDSVPLAAAGNPGAWHAWRTHRRAAGKLTEDTTAAAPSQGGEEKPKEEGEQASDQAQDKATPASPAVTTRHPGEWNWDGVWEDRVKKGIASSLSEPVLYGGTNTADDLIKFLPMEDNDVDSVKENLRRTLGQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8Q6</accession>
    <name>C7Z8Q6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_43364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU38993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044706.1">
        <property type="nucleotide sequence ID" value="XM_003044660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8Q6"/>
    <dbReference type="STRING" id="660122.C7Z8Q6"/>
    <dbReference type="GeneID" id="9673208"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_43364"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_43364"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_6_1_1"/>
    <dbReference type="InParanoid" id="C7Z8Q6"/>
    <dbReference type="OMA" id="FHLWPGV"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="89"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU38993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="313" mass="34644" checksum="0194ADC053241DA9" modified="2009-10-13" version="1">MATLRYDPEFAKALEPLRSKRPSGPPQTALEIRRNNDALFKNMFPKAPSADIIQQTDYTIQSYDGANILLRRFAKPEHLSVKEPLPTILAIHGGGFISGSVDACAGLVANKVLAADRPIFAVGYRLAPEHPHPAPVEDSYAALKYLLDHAAELNIDPQRVAVQGESAGGGIAVGLALLARDRELQPSIAKLLLTYPELDDRPRHDKDAEFLKFTTWSPKHNELAWAAYADVSPYAAPARAATYKGLPSTYVDVGTLDVFREENMEFVRRLLADNVEVEFHVWPGVPHVFEFLGPGTKWHVRATEARVNAMKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9Y6</accession>
    <name>C7Z9Y6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Vacuolar protein sorting-associated protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_100996</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the MSS1-MTO1 complex that catalyzes the 5-carboxymethylaminomethyluridine (cmnm(5)U) modification at the 34th wobble position (U34) of mitochondrial tRNAs.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MnmG family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045296.1">
        <property type="nucleotide sequence ID" value="XM_003045250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9Y6"/>
    <dbReference type="FunCoup" id="C7Z9Y6">
        <property type="interactions" value="744"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z9Y6"/>
    <dbReference type="GeneID" id="9672077"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100996"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100996"/>
    <dbReference type="eggNOG" id="KOG1299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006656_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z9Y6"/>
    <dbReference type="OMA" id="DADMIGK"/>
    <dbReference type="OrthoDB" id="10266265at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000145">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000002">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.830.10:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="entry name" value="GidA associated domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00129">
        <property type="entry name" value="MnmG_GidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049312">
        <property type="entry name" value="GIDA_C_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047001">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00136">
        <property type="entry name" value="mnmG_gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="GLUCOSE INHIBITED DIVISION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PROTEIN MTO1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21680">
        <property type="entry name" value="GIDA_C_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="SAM_GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01228">
        <property type="entry name" value="GIDA_assoc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain" evidence="13">
        <location>
            <begin position="1119"/>
            <end position="1190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU39583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1205" mass="133411" checksum="C67FE961C3E046A6" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9Z2</accession>
    <name>C7Z9Z2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GDP-mannose transporter</fullName>
            <shortName evidence="7">GMT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_43433</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cytoplasmic vesicle membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045300.1">
        <property type="nucleotide sequence ID" value="XM_003045254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9Z2"/>
    <dbReference type="FunCoup" id="C7Z9Z2">
        <property type="interactions" value="580"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z9Z2"/>
    <dbReference type="GeneID" id="9672255"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_43433"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_43433"/>
    <dbReference type="eggNOG" id="KOG1444">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025360_1_2_1"/>
    <dbReference type="InParanoid" id="C7Z9Z2"/>
    <dbReference type="OMA" id="VWMLINC"/>
    <dbReference type="OrthoDB" id="417037at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU39587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="390" mass="42771" checksum="4D8A0751D62AB8AF" modified="2009-10-13" version="1">MTDKKNEDYVVRMGDDYGKKEKDAFLARSPTRSAYGSNMHGNSLEQLEKSPPLSIVAYCFSSISMTVVNKYVVSGSFWNLNFFYLTVQAIVCIATITLCKQLGLIKVLAPFDPDRAKKWFPISLLLVGMIYTSTKSLQFLSVPVYTIFKNLTIIVIAYGEVLWFGGSVTPMALLSFGLMVLSSVVAAWADIQSAIAGDFGTSNSADAMSTLNAGYAWMGMNVFCSAAYVLGMRKVIKKMNFKDWDTMYYNNLLTIPVLVVCSLISEDWSAFNFARNFPEETRNKIIIGMIYSGLAAIFISYCSAWCIRVTSSTTYSMVGALNKLPIAISGLVFFSAPVTVGSVSAIFIGFVSGIVYAWARVRQSVSSRNSLPTVRPTMSASAKSARDANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZA31</accession>
    <name>C7ZA31_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Cellulase</fullName>
            <ecNumber evidence="3 10">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_94623</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 45 (cellulase K) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3 10"/>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044915.1">
        <property type="nucleotide sequence ID" value="XM_003044869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZA31"/>
    <dbReference type="GeneID" id="9672276"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94623"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94623"/>
    <dbReference type="eggNOG" id="ENOG502QTGS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045022_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZA31"/>
    <dbReference type="OMA" id="NYSPWAV"/>
    <dbReference type="OrthoDB" id="10035502at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22278">
        <property type="entry name" value="DPBB_GH45_endoglucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052288">
        <property type="entry name" value="GH45_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000334">
        <property type="entry name" value="Glyco_hydro_45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39730">
        <property type="entry name" value="ENDOGLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39730:SF1">
        <property type="entry name" value="ENDOGLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02015">
        <property type="entry name" value="Glyco_hydro_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01140">
        <property type="entry name" value="GLYCOSYL_HYDROL_F45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002989062" description="Cellulase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="13">
        <location>
            <begin position="360"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="218"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="251"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU39202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="401" mass="41536" checksum="35FE5F2A1E490210" modified="2009-10-13" version="1">MRSSTLIALVGPLAVHAASGNGHSTRYWDCCKPSCSWSGKASVSAPALTCDKNDNPISDADAKSGCDGGSAFACTNYSPFAVNDNLAYGFAATKLSGGSEATWCCACYALTFTTGPVKGKTMVVQSTNTGGDLGENHFDLQMPGGGVGIFDGCSSQFGGSGLGGAQYGGISSRSDCDKFPELLKDGCYWRFDWFQNADNPDFTFEQVQCPKALTDISGCKRNDDSSFPAYKGDTSSSGSTGSKASTSKAAVQSQKTQAPASTKVQQPSNPQTQVQSSASNPQKTQVQNSASNPQKTQVQNSASQPQQTQAPVKEPATPKTTKVGASKTRSGCSVPKKTKQTAQATAKASATKSAPATAQSAVAAWYQCGGSKSAYPNGNLPCASGSTCVQHNEYYAQCVPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAG1</accession>
    <name>C7ZAG1_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_82086</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045385.1">
        <property type="nucleotide sequence ID" value="XM_003045339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAG1"/>
    <dbReference type="STRING" id="660122.C7ZAG1"/>
    <dbReference type="GeneID" id="9672340"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82086"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82086"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_0_1"/>
    <dbReference type="InParanoid" id="C7ZAG1"/>
    <dbReference type="OMA" id="FMEVLQY"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF283">
        <property type="entry name" value="RETINOL DEHYDROGENASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU39672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="351" mass="37134" checksum="86C3E588C683B322" modified="2009-10-13" version="1">MTSNSQFDNKTTGTEVAAAFGDEIRGKNVVITGVSPSSIGASTALAIASQAPATLVLASRTQSKLEAVAAEIKAKYPTVPVKVVLLDLSSIESIKAAAAEIGTALDHIDILINNAGLNLQTRDTVTTPGGIKVDQQLFTNHVGPFLLTELLLPKIISAASKGPKGSVRIVNVSSHGHRLSPIRFSDYAFEKDLYNGVPEEERPPTAVIPGFLQAKDGYPGFIGYGQSKAANVLHSVELTRRLQKAGSNVSALSVHPGTIDTGLTRSLDTEGRGTMGGTAPGGVWKTMDQGAATTLVAAFDPKLTEGRTKPYWYLSNCQPDDERLAAHAYDPKAAEKLWSETEKMLGIKSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAI5</accession>
    <name>C7ZAI5_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_82109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044993.1">
        <property type="nucleotide sequence ID" value="XM_003044947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAI5"/>
    <dbReference type="GeneID" id="9672352"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82109"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82109"/>
    <dbReference type="HOGENOM" id="CLU_1741042_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZAI5"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU39280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="150" mass="15758" checksum="78F9C05AB5EDDCD3" modified="2009-10-13" version="1">MPHVALDGVQKSLRRSSIGRLWPVQGPILEISAALPNLRSPDGMVRDVAALVRAAPTACSLQPQTKAAIGTIASAAKEQRSKWKLCRSRRVVGFKLSGLLTNGGIPPPVFHGSREGGARPVPKIADMDQAPLVVVPGYLQEILPTGSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZB62</accession>
    <name>C7ZB62_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_83219</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044592.1">
        <property type="nucleotide sequence ID" value="XM_003044546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZB62"/>
    <dbReference type="GeneID" id="9672769"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83219"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83219"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_4_2_1"/>
    <dbReference type="InParanoid" id="C7ZB62"/>
    <dbReference type="OMA" id="FWILFFW"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015233">
        <property type="term" value="F:pantothenate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098717">
        <property type="term" value="P:pantothenate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF4">
        <property type="entry name" value="PANTOTHENATE TRANSPORTER FEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="57"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="513"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU38879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="534" mass="59386" checksum="B897C4AC7E724C02" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBX8</accession>
    <name>C7ZBX8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alcohol dehydrogenase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_55265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698916">
        <property type="protein sequence ID" value="EEU38490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044203.1">
        <property type="nucleotide sequence ID" value="XM_003044157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBX8"/>
    <dbReference type="STRING" id="660122.C7ZBX8"/>
    <dbReference type="GeneID" id="9670544"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55265"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55265"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZBX8"/>
    <dbReference type="OMA" id="YGLEEHH"/>
    <dbReference type="OrthoDB" id="5407715at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05188">
        <property type="entry name" value="MDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350">
        <property type="entry name" value="NAD-DEPENDENT ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350:SF17">
        <property type="entry name" value="NAD-DEPENDENT ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="203"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU38490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="381" mass="40896" checksum="5AFE43BA2CE4C066" modified="2009-10-13" version="1">MSPSSTATKNRGLWLSSFDKPLELVELPVPEATAGSVVVKVLNTVVFPYAEDIHQGRLPVFNLSLPLVPHPSHIGRVHAIGSDAVLAKPGDLVFFSAPIFARDDPDVSIIQGHHGGEGPRGRKLMQGEWRDGALQEYQKVPLENIFILNEDRLCKQLGYTPAELHEISFYTISAGALCEAANLQAGETIALGPATGTFGGVTSDMALALGANVIAIGRSEKNLARLAEQLGNHERFSYVVMTGDDEVDAAAIRKASPDGRGVEVYNDWASGTLTGSPYFSAAIRAVRPEGRVVLSGAPSGSISVPYTLVMHQNIKIIGKVIVSRGGIDSTIKMINSGVLKLGKRGGSKHKVYTLEEHHEAFQDAKQNSGFRVYTNIAPNPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBY4</accession>
    <name>C7ZBY4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Intradiol ring-cleavage dioxygenases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_55328</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698916">
        <property type="protein sequence ID" value="EEU38445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044158.1">
        <property type="nucleotide sequence ID" value="XM_003044112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBY4"/>
    <dbReference type="GeneID" id="9670549"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55328"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55328"/>
    <dbReference type="eggNOG" id="ENOG502QWDJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046727_2_0_1"/>
    <dbReference type="InParanoid" id="C7ZBY4"/>
    <dbReference type="OMA" id="EEWQAGI"/>
    <dbReference type="OrthoDB" id="5238185at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03461">
        <property type="entry name" value="1_2-HQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039390">
        <property type="entry name" value="1_2-HQD/HQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF7">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catechol dioxygenase N-terminal" evidence="8">
        <location>
            <begin position="32"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="7">
        <location>
            <begin position="114"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU38445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="36336" checksum="EC6444D4B079DFEB" modified="2009-10-13" version="1">MSHIRPDIPPLKDLTTENITENVVAINSTCQNPRTRFLFERLTHHLHDFARETRLSTTEWEAAIQFLTRTGKICSDTRQEFILLSDVLGLSLLVDSIDHPKPPTSTEGTVLGPFHAHGAENVASGHTISHDPEGEPLLVVCSVKDSQGNPLADVEVDVWETDSKGFYDVQYADREGFDNRAVLHSDHQGKFYFKAIVPVPYPIPDDGPVGQLLKILNRHPYRPSHMHFKFKKAGYDPLITALYIRGDPYETSDAVFGVKESLIVDLKKVSEAPGLAEAYGVSETTKLLQYDFVLVSETEVAALRHAEALKSAGTLGAGVQVVDGTLYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZC40</accession>
    <name>C7ZC40_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_106587</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the secreted LysM effector family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698917">
        <property type="protein sequence ID" value="EEU38415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044128.1">
        <property type="nucleotide sequence ID" value="XM_003044082.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9670477"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_106587"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_106587"/>
    <dbReference type="eggNOG" id="ENOG502SK24">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002540_4_1_1"/>
    <dbReference type="InParanoid" id="C7ZC40"/>
    <dbReference type="OMA" id="VEIQDMM"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002989116" description="LysM domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="1137"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="1284"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00044955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU38415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1348" mass="147645" checksum="5D4E615AC0456356" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDA2</accession>
    <name>C7ZDA2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_63301</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S12 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698919">
        <property type="protein sequence ID" value="EEU38058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043771.1">
        <property type="nucleotide sequence ID" value="XM_003043725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZDA2"/>
    <dbReference type="GeneID" id="9669882"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_63301"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_63301"/>
    <dbReference type="eggNOG" id="ENOG502S0EY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_14_1_1"/>
    <dbReference type="InParanoid" id="C7ZDA2"/>
    <dbReference type="OMA" id="KWQENYE"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF9">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002987016" description="Beta-lactamase-related domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="48"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU38058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="456" mass="51536" checksum="EC5566576D84B54A" modified="2009-10-13" version="1" fragment="single">MMLFLALHVACLAHLASSQQIPLNEQLSSHSESTDHDSNDVPIADAAFEQYIRDKMARWHAPGLAMAILDGNKTWTRGFGYASLEGEPVTPSTLFYCGSMTKSFTAAALSLLVDQSQDYADIQWSTPVSNLLREDFVLSDDWATSHITVADVLCHRTGYPRHDYAGPFLNSSVNMVHSFRHLPMAGEPRAQWRYSNLMYGTMGYLIETLTGTSLADFFRDRLWLPMGMRNTYLHPDDALASESTLAVPYYWNNDTETYGEIPWRDEQNIAGAGMAISSVLDWSRYLRHMIDETGPISKAGHHTLKLPHKVVEERERLFTGPVYYGFGWFGSVFQDEPVWWHSGLVNSMMSIMLMIPSKKFGFVIMLNSENAPALDSIIAKTLYDFFHVEEGKRQNLEANWNQTYAEWEERLGNCSNRLYPSLPSPPIRAPLPPGRFAGEYYHPGYGPISVSISCDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDF2</accession>
    <name>C7ZDF2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_88179</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043604.1">
        <property type="nucleotide sequence ID" value="XM_003043558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZDF2"/>
    <dbReference type="STRING" id="660122.C7ZDF2"/>
    <dbReference type="GeneID" id="9669435"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88179"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88179"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="InParanoid" id="C7ZDF2"/>
    <dbReference type="OMA" id="HYPKECA"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU37891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="346" mass="37128" checksum="D5EBF9B80CCE6E59" modified="2009-10-13" version="1">MTGELVLLTGGTGFLGYAILVDLLKSGYRVRAAARSQSKVDKVLAAPSISALAPSSDQLTFVMVPDMTAPGAYDDAVQGVDLIVHVAAPLPSGEASRDSPGDAFFKASVEGNLAILKSAHEKGKTVRRIVMTSSTVAIAPADVYVTDTKEREILRGPDNRVVFPPPPYDSELRAYGASKAAALNAAEAFVRDNTTNFDLISIMPSWIFGKDELFTNTQDIRTDSTKVLINGLLTGNQGVPAVGNVVLCADVARAHVRALDTDIKGNQSFVLSTEVKWEDTIPIAKKHFPGAFASGLFKEGSPQPTLPISWDSSKTRDVLGIELATYEDMVKEVVSQYLELAEREEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEI5</accession>
    <name>C7ZEI5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycoside hydrolase family 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_106524</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698921">
        <property type="protein sequence ID" value="EEU37603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043316.1">
        <property type="nucleotide sequence ID" value="XM_003043270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEI5"/>
    <dbReference type="STRING" id="660122.C7ZEI5"/>
    <dbReference type="GeneID" id="9669126"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_106524"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_106524"/>
    <dbReference type="eggNOG" id="KOG2024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009935_3_1_1"/>
    <dbReference type="InParanoid" id="C7ZEI5"/>
    <dbReference type="OMA" id="PQCGSPF"/>
    <dbReference type="OrthoDB" id="408320at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051913">
        <property type="entry name" value="GH2_Domain-Containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732:SF2">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002989053" description="Glycoside hydrolase family 2" evidence="4">
        <location>
            <begin position="25"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="7">
        <location>
            <begin position="104"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="5">
        <location>
            <begin position="230"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 catalytic" evidence="6">
        <location>
            <begin position="352"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU37603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="636" mass="72306" checksum="79B722239C45D063" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEZ9</accession>
    <name>C7ZEZ9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose receptor Git3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_86356</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043198.1">
        <property type="nucleotide sequence ID" value="XM_003043152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEZ9"/>
    <dbReference type="GeneID" id="9665211"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86356"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86356"/>
    <dbReference type="eggNOG" id="ENOG502SIRC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032576_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZEZ9"/>
    <dbReference type="OMA" id="IWIYLRR"/>
    <dbReference type="OrthoDB" id="100006at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023041">
        <property type="entry name" value="Glucose_rcpt_Git3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11710">
        <property type="entry name" value="Git3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose receptor Git3-like N-terminal" evidence="7">
        <location>
            <begin position="110"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="284"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU37485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="475" mass="52559" checksum="8AAF9B5BDA75C95F" modified="2009-10-13" version="1">MTPSIDNGHPVFLPGLEIRHRWVQDGCGRGSGDFLPHLGGQRSFVLSDDFCSDFVRYIPSAFAELSACSRVELGGSRCAFIPDRNSRRPWRSIAHIVPEFINTLNNSVSGIIFLKTGELQPGTPCAVNGMVGQFSVQAADFSILAIALVTLLTVTRFVYMPSVSTKGWILTCLAVWTIPLITSLTPTALGEMVPVGGNWCWISAGRPDLRYGMGHGWRFLVILSTIAIYIYIWAYLRRHLGSKIVDQGSSSYDTPSTGTMGSFWSKAGRKGGFQVMKDEEVELSTFGDGSNTANSRREINDDEIRSSNKEELAGLDLEAAEESGSSSTRPRRRSTRHMSSATRKELGLPTPAHVRYDDASPVGRHGQGATLQTNASEFPIRRDTHEVEVEIKRMMLLNAYPFMYVLLWMPGLINRIMEASGHSTSKTTIAALQISTQYIGLANALTYGFNHHLRDRLKGMYLTPAVSRIKKRFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZG40</accession>
    <name>C7ZG40_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_52287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698924">
        <property type="protein sequence ID" value="EEU37012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042725.1">
        <property type="nucleotide sequence ID" value="XM_003042679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZG40"/>
    <dbReference type="STRING" id="660122.C7ZG40"/>
    <dbReference type="GeneID" id="9664841"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_52287"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_52287"/>
    <dbReference type="HOGENOM" id="CLU_002639_8_3_1"/>
    <dbReference type="InParanoid" id="C7ZG40"/>
    <dbReference type="OMA" id="NECEATH"/>
    <dbReference type="OrthoDB" id="5362512at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="52"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="335" mass="38000" checksum="363A03749D82BC39" modified="2009-10-13" version="1" fragment="single">FALGALKECLDNHTLCDNGTDHGFLPSRLVEVQETSVRVVETHQLDPAQTKYLALSHCWGPPESITAQLNDETYEEYMKEIPAAALPKTFKDAIAITRKLGYQYIWVDSLCIIQHNVGCWIKEGSQMCQIYENSLVTLAAASSSSGQGGLFYNSPKIEITGTVPESGKEYQLFARFNFNHRFFDYPLMNRAWVMQERLLSPRTLYFTSQELVWECRSRNVCQCSPILGGFRAQVDGFPDNSKLQPAEAHLDTSALVSKWYEVVEIYTQLKLTHASDKLMAVDGIAQYMAPLRESQHFAGLWIDSFATDLAWAVDTFDDERGRVPEWRAPTWSWAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZG49</accession>
    <name>C7ZG49_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_52117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698924">
        <property type="protein sequence ID" value="EEU37017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042730.1">
        <property type="nucleotide sequence ID" value="XM_003042684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZG49"/>
    <dbReference type="GeneID" id="9664846"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_52117"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_52117"/>
    <dbReference type="eggNOG" id="ENOG502SYW6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086503_2_0_1"/>
    <dbReference type="InParanoid" id="C7ZG49"/>
    <dbReference type="OMA" id="DMELMVC"/>
    <dbReference type="OrthoDB" id="10039976at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053144">
        <property type="entry name" value="Acetyltransferase_Butenolide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43233">
        <property type="entry name" value="FAMILY N-ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43233:SF1">
        <property type="entry name" value="FAMILY N-ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="203" mass="22642" checksum="B4B66883D236BB5A" modified="2009-10-13" version="1">MALSIKQQLQNRTWTKGSYLISTDRTLLPTQKLQEVFASDDFYWAKPLPTDAMLDVLENSLCFGLYEQSQSDGTASSSQPQFIGIARCITDYVTFIYLTDVWVDPKYQGQGLGTWLLKSIQQVIEAMPYLRRSLLFTGDWERSVPFYERVMGMEVMQGGNGQGLAVMGRKGKGHSTYVEDENCWLAAVGSLGPGTPQLDGDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZGF6</accession>
    <name>C7ZGF6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_94041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698925">
        <property type="protein sequence ID" value="EEU36925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042638.1">
        <property type="nucleotide sequence ID" value="XM_003042592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZGF6"/>
    <dbReference type="GeneID" id="9669980"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94041"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94041"/>
    <dbReference type="eggNOG" id="ENOG502SH7Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003772_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZGF6"/>
    <dbReference type="OMA" id="YYQYQDL"/>
    <dbReference type="OrthoDB" id="2588159at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053161">
        <property type="entry name" value="Ulvan_degrading_GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36848">
        <property type="entry name" value="DNA-BINDING PROTEIN (PUTATIVE SECRETED PROTEIN)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36848:SF2">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17132">
        <property type="entry name" value="Glyco_hydro_106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002989109" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU36925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="842" mass="92556" checksum="434B1153CCC5C6DE" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZGH7</accession>
    <name>C7ZGH7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">L-xylulose reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_81004</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698925">
        <property type="protein sequence ID" value="EEU36893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042606.1">
        <property type="nucleotide sequence ID" value="XM_003042560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZGH7"/>
    <dbReference type="STRING" id="660122.C7ZGH7"/>
    <dbReference type="GeneID" id="9670106"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_81004"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_81004"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="InParanoid" id="C7ZGH7"/>
    <dbReference type="OMA" id="EMKEEWF"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF13">
        <property type="entry name" value="L-XYLULOSE REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU36893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="29909" checksum="BEEAFCA1837429CE" modified="2009-10-13" version="1">MSQISNGNGRQSIRNPNPPIEDSVFKSLRLDGRTVIITGGCGGIGYEVARGLAEAGANLALWYHSSQNAAKLSAKIASDFSVTVKTYQVDVRDNTQVEATVDKVVQDFGRLDVMIANAGIPTKAGGLDDTIEDWNNVRAIDFDGAYYSVRAAGRVFREQKRGVGIITASMSGHAANVPQEQTCYNACKAGCIHLAKSLSVEWAKWGGRINSVSPGYIDTAISGDCPFEMKEEWYSLTPLKRDADPRELKGIYLYLASDASSYTTGADFVIDGGYTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHL4</accession>
    <name>C7ZHL4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein NO VEIN C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_81180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698928">
        <property type="protein sequence ID" value="EEU36433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042146.1">
        <property type="nucleotide sequence ID" value="XM_003042100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHL4"/>
    <dbReference type="GeneID" id="9669333"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_81180"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_81180"/>
    <dbReference type="eggNOG" id="ENOG502QQIR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1152041_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZHL4"/>
    <dbReference type="OMA" id="YLEDSWR"/>
    <dbReference type="OrthoDB" id="1262810at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024975">
        <property type="entry name" value="NOV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13020">
        <property type="entry name" value="NOV_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein NO VEIN C-terminal" evidence="2">
        <location>
            <begin position="153"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU36433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="241" mass="27143" checksum="23EBF99220203FB9" modified="2009-10-13" version="1">MSYRPHLGGGDDPSRPPLFHHSSLSLNASSYHAPTQPGGRSEDAQYRAILDRVVEKARRTTFGTINSSGRRDTLSSGGRHADAYESFDGLDVVGKFRSTNQLERDKKIGAAGELFNRRETADLVYVDSAGHFTDMLIGCGYLDHDDWHGARPKYYIEVKTTTRPRDTPFYMSGKQYRLMQRVHSTEDRSEVYMIFRVFCLNDDGIGLSVYFDPEKLRQDGQLEFTGQTWSVTPVNGTEADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJG2</accession>
    <name>C7ZJG2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-reducing end alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_91575</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="GG698933">
        <property type="protein sequence ID" value="EEU35844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041557.1">
        <property type="nucleotide sequence ID" value="XM_003041511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZJG2"/>
    <dbReference type="STRING" id="660122.C7ZJG2"/>
    <dbReference type="GeneID" id="9673984"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_91575"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_91575"/>
    <dbReference type="eggNOG" id="ENOG502QQEX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010060_1_1_1"/>
    <dbReference type="InParanoid" id="C7ZJG2"/>
    <dbReference type="OMA" id="PGRESDW"/>
    <dbReference type="OrthoDB" id="406864at2759"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055235">
        <property type="entry name" value="ASD1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051563">
        <property type="entry name" value="Glycosyl_Hydrolase_51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776:SF0">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22848">
        <property type="entry name" value="ASD1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988166" description="non-reducing end alpha-L-arabinofuranosidase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-arabinofuranosidase C-terminal" evidence="9">
        <location>
            <begin position="448"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU35844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="643" mass="70143" checksum="BF9B2E72CD182FBF" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZJS2</accession>
    <name>C7ZJS2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_44395</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="9676301"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_44395"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_44395"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_008455_11_3_1"/>
    <dbReference type="InParanoid" id="C7ZJS2"/>
    <dbReference type="OMA" id="IHYLAPI"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF38">
        <property type="entry name" value="POLYAMINE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
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    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="187"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="326"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
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        <location>
            <begin position="40"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU35753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="482" mass="52463" checksum="703DFDE7EB5B93A2" modified="2009-10-13" version="1">MHDDEAGSCLKAEPGSSGHNLSPTDPDSPMTWSFLKKVYVSAVSFAFVFVVMYGTTTYTAAVNAVPAAFGVSQRTALLGFTMPFYGVFFAPIYTPHLSERYGRRPIYFTSFPLFSLCVVVIGLASNISTLLAFRFLAGLFGGPCLVLIEGTFADVWPAHKTVTYYSFLTLASYSGAALGPLIGGFVFSVKGPAWLSWVTLLFAMAAMAFGAFMPETYNREILRTRIRYNKSGIKLPCAQSGVTTSEMAHITFFTPLKMLFTEPLVILITLYLGLNFGVLFQWFISVPAALNAAYGFDVKKAGLAFLSALIGVVFALVSSSSLEALFSKPTKHGMESIEKRLIPAMVGSFFVAGSLFWVAFTAKPTVHYVVPICGTAFYVWGNAMVLISFISYLFDAYPAAGTLSALTTAACFRVACAGIVPLFILDVLKDLDGDWTFSTFGILSAIMGTFPFVLYWFGLSWRSRSKYSGGYMSASMTEESIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKC3</accession>
    <name>C7ZKC3_FUSV7</name>
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        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_55481</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698938">
        <property type="protein sequence ID" value="EEU35532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041245.1">
        <property type="nucleotide sequence ID" value="XM_003041199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKC3"/>
    <dbReference type="GeneID" id="9675970"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55481"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55481"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012970_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZKC3"/>
    <dbReference type="OMA" id="DQSATIF"/>
    <dbReference type="OrthoDB" id="4078873at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF107">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="537"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU35532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="575" mass="63096" checksum="32913D58DF5F71FE" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKX3</accession>
    <name>C7ZKX3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_99796</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698942">
        <property type="protein sequence ID" value="EEU35308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041021.1">
        <property type="nucleotide sequence ID" value="XM_003040975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKX3"/>
    <dbReference type="GeneID" id="9675419"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_99796"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_99796"/>
    <dbReference type="eggNOG" id="KOG1192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000537_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZKX3"/>
    <dbReference type="OMA" id="WSQALIP"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000268">
        <property type="entry name" value="Glycosyltransferase family 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF13">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="3">
        <location>
            <begin position="95"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="4">
        <location>
            <begin position="412"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU35308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="887" mass="96875" checksum="20618ABADEC70513" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZL33</accession>
    <name>C7ZL33_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_78308</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698942">
        <property type="protein sequence ID" value="EEU35336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041049.1">
        <property type="nucleotide sequence ID" value="XM_003041003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZL33"/>
    <dbReference type="GeneID" id="9675413"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78308"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78308"/>
    <dbReference type="eggNOG" id="ENOG502SHRF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016969_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZL33"/>
    <dbReference type="OMA" id="ERIVIMS"/>
    <dbReference type="OrthoDB" id="5419927at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40619">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40619:SF3">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="414"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU35336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="599" mass="68050" checksum="11E610C701259FF2" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZL44</accession>
    <name>C7ZL44_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Conserved oligomeric Golgi complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_54508</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698943">
        <property type="protein sequence ID" value="EEU35251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040964.1">
        <property type="nucleotide sequence ID" value="XM_003040918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZL44"/>
    <dbReference type="FunCoup" id="C7ZL44">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZL44"/>
    <dbReference type="GeneID" id="9675369"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_54508"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_54508"/>
    <dbReference type="eggNOG" id="ENOG502QQP3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030042_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZL44"/>
    <dbReference type="OMA" id="YFWRTLA"/>
    <dbReference type="OrthoDB" id="18786at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019465">
        <property type="entry name" value="Cog5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048485">
        <property type="entry name" value="COG5_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049176">
        <property type="entry name" value="COG5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228:SF3">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20649">
        <property type="entry name" value="COG5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10392">
        <property type="entry name" value="COG5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 N-terminal" evidence="6">
        <location>
            <begin position="17"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU35251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="446" mass="49014" checksum="11082FE4228CBAC2" modified="2009-10-13" version="1">MAADPAADEEPSYIDYETFLDPDFSPASFANSLVVSTNNPNDTPLDLSTPLSRVLFDAQEIDSHIDVLTTRSAVPLLNYTQQQTQASKHIVAELDGQIKSLNDSYRQLEKEVIDKHAEADEVRLVALRLWETLKLGRSVGRCLQLGRQLEVQHSELELPGNGPGASGKEDHRALVRCGYTILSLREVLDRKAPGEEGFGLNRVDTVRSLQDTVITPIERSVRERAERIICEFSVQSVSTFAQVDETKSRTVSALTTLYLLSPTLGFKPEKWTPRLLLQALETYIRSALQASITALSRSLGQLPTLEKSLTEVMAKCQNIVSLEAVLESTKPPTHPLLPAANQPSQTNLLQFLLAHLETGSLASFFWRTMASSLATRVQDIVNRGGVVARTLRTNKNTVGDAIRQAVVKGSQLHSALSGPKARTKADANWDREVAVMVGSVVNNLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLG8</accession>
    <name>C7ZLG8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_5061</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698945">
        <property type="protein sequence ID" value="EEU35133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040846.1">
        <property type="nucleotide sequence ID" value="XM_003040800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLG8"/>
    <dbReference type="STRING" id="660122.C7ZLG8"/>
    <dbReference type="GeneID" id="9679261"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_5061"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_5061"/>
    <dbReference type="eggNOG" id="KOG2820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_0_1_1"/>
    <dbReference type="InParanoid" id="C7ZLG8"/>
    <dbReference type="OMA" id="AMQMPTI"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF46">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU35133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="386" mass="42309" checksum="D1E6435FC112C476" modified="2009-10-13" version="1" fragment="single">VIIIGAGAFGLSTALHLQRHHRDAVDVLLRDSASFPSIDSASGNDTSRAVRMDYADPFYFNLAKEAIEAWQGDPVFSQHFHLSGRIGAQPPGHTNVEKCKHVLQAAGVDVEDFGEADKVSSLHNMFPLLGNRDKLRGWDFYYVKHAGWANPKEAVISAMKDYQSLGGRQITDRWRGCVVDNIISGNQIRGVKTADGQSHFAEHVIYATGAFSTSNKKLLPGLGTQIHPTGFAIAHWKLENSEELKAWQGYPAVDIYHNGYFFPPDPITGLMKLGLGIVGFTHDENPRSSWEDQSDVGIALRNSDLVSTNEAGKIPAIAEEGIRWILNRWAPSLANKKFLDMKICWDAMTPDGGWLIDHHPGIQGLSVATGGSGHGFKFLPVVGSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLP4</accession>
    <name>C7ZLP4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_44802</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698946">
        <property type="protein sequence ID" value="EEU35100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040813.1">
        <property type="nucleotide sequence ID" value="XM_003040767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLP4"/>
    <dbReference type="STRING" id="660122.C7ZLP4"/>
    <dbReference type="GeneID" id="9679213"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_44802"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_44802"/>
    <dbReference type="eggNOG" id="KOG0022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_14_1_1"/>
    <dbReference type="InParanoid" id="C7ZLP4"/>
    <dbReference type="OMA" id="FSACKSC"/>
    <dbReference type="OrthoDB" id="1560166at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08278">
        <property type="entry name" value="benzyl_alcohol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350:SF2">
        <property type="entry name" value="GROES-LIKE ZINC-BINDING ALCOHOL DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350">
        <property type="entry name" value="NAD-DEPENDENT ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="20"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU35100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="384" mass="40722" checksum="AC3D5D95BE45A5F0" modified="2009-10-13" version="1">MKANVQTTQAIVSHAPEDGKRRWILEDVQVSEPGEYEAIVEMVASGVCHTDLGCGTAPDGTPGFPVPPYPRVLGHEGAGFVRAVGSKITKVKPGDAVLLSFAFCTKCHNCKFGAPGYCHEFSALNFAGTKKAFQFPTGTGPDVGGSFFGQSSFSKLSRVQETSLVNVSQLVRNKNDLKLLAPLGCGIQTGAGTVTELAAAKPSDKVAIIGLGGVGLAAIMAAKLKGCRTIIGIDRVPARIGMAKKLGATHGIDTSTISNLVDEVRKVTEGSGSTITVDATGVLPLIQQGLEFTANQGKMILLGVAPMDAGLEIAVVPYMVTGKQIMGSMEGGVYPEDYIPKMIRWYQNGEFPVDELIKFYPVQDYQKAIRNMEDGSTIKPVLIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZM41</accession>
    <name>C7ZM41_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_79789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698949">
        <property type="protein sequence ID" value="EEU34900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040613.1">
        <property type="nucleotide sequence ID" value="XM_003040567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZM41"/>
    <dbReference type="GeneID" id="9679049"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79789"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79789"/>
    <dbReference type="eggNOG" id="ENOG502SJKS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008719_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZM41"/>
    <dbReference type="OMA" id="FANCAPV"/>
    <dbReference type="OrthoDB" id="4525710at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF25">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="408"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="413"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU34900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="455" mass="51348" checksum="49EB18214FC22445" modified="2009-10-13" version="1">MAASIGQGWSNPLPSLLPVAEPLEEEETGSETGFIAEFGFGPPLDNRKEAEYFMHFIHELAPWFDVCDPARHFGTEVPKRARHFPFLAYSILAFSSRQISLKSGIPDDSHETYHSHALRILIPILDDPIGAVNENVLAGIVILRSYEEMTDMDGSTHLTGSSRLLNSEFRFAAQGGLGEAASWVVLRQDMYVSLTRSRPLRTNMDSYRDSQSFVDTCDESLANRVVFICGRVLAYAFGPESRLDPVLWAELGEDLRRWYEATPWKVLSWSPDSPAREGGEKSVFPTLWMARHIQVLGYQHYYIARMLLNIFDPQLWTPGFDAIRLRAASDEAVRKDLRTLLGLTISNPNLPTAYFTAHHTLYACGVYLKDEREHQEVFRFLEDMSNTMGWPTREVAAQLRKDWGVDKGIPENASISPHQLSAQRFSGDQAWDPEPGVWGQGSPMDKEENSVIHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNB4</accession>
    <name>C7ZNB4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methylitaconate delta2-delta3-isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_55022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpF family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698965">
        <property type="protein sequence ID" value="EEU34493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040206.1">
        <property type="nucleotide sequence ID" value="XM_003040160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNB4"/>
    <dbReference type="GeneID" id="9678029"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55022"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55022"/>
    <dbReference type="eggNOG" id="ENOG502SHIK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026443_0_1_1"/>
    <dbReference type="InParanoid" id="C7ZNB4"/>
    <dbReference type="OMA" id="MQRIPCV"/>
    <dbReference type="OrthoDB" id="10267539at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007400">
        <property type="entry name" value="PrpF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709">
        <property type="entry name" value="ACONITATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709:SF2">
        <property type="entry name" value="DUF453 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G00360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04303">
        <property type="entry name" value="PrpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU34493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="46634" checksum="F22D1BF62A9D785E" modified="2009-10-13" version="1">MALQEKHSQGSHLIRHSLPCVLMRAGTSKGLFLHRSHLPEKEVGWPSHLISALGSRNNDPRQVDGVGGGTSTTSKVAVVSPSLRPDADVDFTFVQVAVGRESVDFSGNCGNMSSGVGPFAVQEGLVVPQPGQAEIDVRIFNTNTNRIIVETIEIDETGQYKEDGNYTIPGVKSFGSEVKCSFVDPAGSMTGSLFPSGQKQQWLNILSCPLVPQLELFRVRVTLIDAANPFVLVDSSSISGILKTLPSPETQHQLVESIRLKGAVAMGLASSIEIAAQTRGTPKIALLRSPVRRTAKDIEKPGIRVQSYSMGLPHPSLQLTGAVCLGAAVSVKGTIAADLAALVDIDESLPPTPKRTPPPNIKGDREMDDEVRTVLIEHSKGTIPVRVVRRGEEEIASCAVSRTARRLFEGRVIYYTETSSRAFAEKHSFKKMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNY2</accession>
    <name>C7ZNY2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbohydrate esterase family 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_49924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039991.1">
        <property type="nucleotide sequence ID" value="XM_003039945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNY2"/>
    <dbReference type="STRING" id="660122.C7ZNY2"/>
    <dbReference type="GeneID" id="9677926"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_49924"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_49924"/>
    <dbReference type="eggNOG" id="ENOG502SKVX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015101_3_1_1"/>
    <dbReference type="InParanoid" id="C7ZNY2"/>
    <dbReference type="OMA" id="WGAWALE"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01846">
        <property type="entry name" value="fatty_acyltransferase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF22">
        <property type="entry name" value="GDSL LIPASE_ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002989006" description="Carbohydrate esterase family 16" evidence="2">
        <location>
            <begin position="19"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU34278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="32930" checksum="1111FBBAAD7DB6C7" modified="2009-10-13" version="1">MRLHIALVLTCDAFLASAYPRPNRLFSRLIVFGDSFSDNGNGAWVGSNGTWPVDPAYFNHSFSNGPKWNDLVAEVLDLELINLATGGATTDNDFVAGGTGASSTIPVPSADDQITAFLSRDKPTETDIFVHWIGANDILFNTNITGIEVTSLISKHANRLYRAGIKNLILANYNNATTFPATYNSSDYNVPSVQAFVGDLSIGLMDIAAGYSGFFRTAFVDIGALFSDIVKRPARYDIDRKYVDPPTACLTGVYTSEGVPRHLCSDPERHLFFDSYHPVKEVHAMMAKMFIKAIQGLSRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNZ6</accession>
    <name>C7ZNZ6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_96569</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039907.1">
        <property type="nucleotide sequence ID" value="XM_003039861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNZ6"/>
    <dbReference type="GeneID" id="9677816"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_96569"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_96569"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="InParanoid" id="C7ZNZ6"/>
    <dbReference type="OMA" id="YFCATTV"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU34194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="288" mass="30813" checksum="7FA7D61CB22FB63F" modified="2009-10-13" version="1">MSPSALETPTTVPTNAAAETSSTYLNTQPGPDHDWRITLKDKVIAITGANRGIGLGIAEVCLANDAAAVFSLDLFEPGDEFLAVQTANPKRFSYINCDVTSEESITSAIDSIISKRGAIHGLVANAGMTKHQPALDFDRAQLDKLFNLNVFGAYFCATAAARRFIELGIKGSIVFTASMTSYRPNRAAPSAPYGATKGAVRNMTHTLAMEWAKHGIRVNSISPGFVKTAMTYFVDQTPDWGLKMQYYGGMPRLADPKELGGAYVYLLSDGASYTTGIDIPVAGIVGAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZP41</accession>
    <name>C7ZP41_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HpcH/HpaI aldolase/citrate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_85587</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039995.1">
        <property type="nucleotide sequence ID" value="XM_003039949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZP41"/>
    <dbReference type="STRING" id="660122.C7ZP41"/>
    <dbReference type="GeneID" id="9677930"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85587"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85587"/>
    <dbReference type="eggNOG" id="ENOG502QR7H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059964_3_1_1"/>
    <dbReference type="InParanoid" id="C7ZP41"/>
    <dbReference type="OMA" id="HYLALGC"/>
    <dbReference type="OrthoDB" id="1621678at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000004">
        <property type="entry name" value="5-keto-4-deoxy-D-glucarate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF9">
        <property type="entry name" value="HPCH_HPAI ALDOLASE_CITRATE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="3">
        <location>
            <begin position="33"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU34282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="269" mass="29126" checksum="DAE485F3CA0E1A30" modified="2009-10-13" version="1">MTQKTYPTALTTEIENPRLRFLNKIKAGEYPLMTFVAIPSVRQAQIVALTGLDGVILDCEHGHIGDDSMHNSVAAISALGVSPIIRIRGPAHDIIKRALDTGAHGIMVPQINNAEEARQIVQSSKFPPQGVRGQGSAFPAIGHGLTTPEYMKSANETILTMIQIETRAGVENVDEICAVPGVDMVFIGPNDLAQSLLGYVPARGDEPEFLAAIDKIIAAGRRHGKWVGRMVNNGTAAKEARERYDTVAITGDTKAIQNWYMAEFEIARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZP95</accession>
    <name>C7ZP95_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acyltransferase MbtK/IucB-like conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_50302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lysine N-acyltransferase MbtK family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040021.1">
        <property type="nucleotide sequence ID" value="XM_003039975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZP95"/>
    <dbReference type="STRING" id="660122.C7ZP95"/>
    <dbReference type="GeneID" id="9677660"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_50302"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_50302"/>
    <dbReference type="eggNOG" id="ENOG502RZMI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027095_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZP95"/>
    <dbReference type="OMA" id="FPHKQSW"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438:SF1">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13523">
        <property type="entry name" value="Acetyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU34308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="56848" checksum="4AA98FEE667EF414" modified="2009-10-13" version="1">MAPQVIRLPDGQTFTVTPVFAGLGFKSHELNTHHNAFPIGWTVVLNTETETDADTEADPTSEDKGDNDVEKQGPENEGNGVALDGESSSATRSVKRHIHSFAKPTLQGDNLFISSIANPSSSEFKPAASPTRQIAMMLWITLYWYFHQPEPAPQVPADAAKLTPHAAKPRGEWRINIKRDGVLRGRNLIPKLERMGLIASANSAVGTSLDDNSDGWSNMFVSRRMFWQLPGRLFLFSLQPNRVGNFDSTPGSPIGSRPGSPIRGESQAPFHKAFPRHSPHSSYGRLDTDLPGGPMPTSMASVPSFPIGPFFSSSHLPTYYPPPPLQYVFTNNIRHPMRPKPPRMGEVFYTRFVPSVCQYLSFRVASISPNPVPYLGPVGPKPPEQTHLSALSDTSLLQMWMGKPRVSAFWNEYDPQFLTNSLNSTNSFPVIGMWDGVPFGYFEIYWVKEDILGQHLGSDAGDWDRGLHVLIGEEWARGRVPIWLTGLVHWCLTSDYRTMNICLEPRVDNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPM1</accession>
    <name>C7ZPM1_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_85764</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRN7/TAF1B family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040089.1">
        <property type="nucleotide sequence ID" value="XM_003040043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZPM1"/>
    <dbReference type="STRING" id="660122.C7ZPM1"/>
    <dbReference type="GeneID" id="9677829"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85764"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85764"/>
    <dbReference type="eggNOG" id="KOG0003">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081075_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZPM1"/>
    <dbReference type="OMA" id="IKWANDR"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048540">
        <property type="entry name" value="Rrn7_cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033599">
        <property type="entry name" value="TAF1B/Rrn7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021752">
        <property type="entry name" value="TF_Rrn7_Zf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576:SF2">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20644">
        <property type="entry name" value="Rrn7_cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11781">
        <property type="entry name" value="Zn_ribbon_RRN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRN7-type" evidence="11">
        <location>
            <begin position="11"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Rrn7/TAF1B N-terminal cyclin" evidence="12">
        <location>
            <begin position="87"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU34376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="224" mass="25753" checksum="573A650B6A87F3EE" modified="2009-10-13" version="1">MDERRDLRKFPRGERCPECGARKWYLENGLRFCSNGHQVEGFVQFDMGDEQDAGKMGSVARREKETKEKELRHLTGQAGKNLFLESLQLILRNQLLWLIKEKGHREELETVVRDLWDLRTRGSGSLVIDDAPTADLEMFSSQPTGDEKNATSTKSASRAQSWDPERGPDWPMPRMLDTLALCYLGCLLLRIPTGIGELCLWVNNGHMPYKRALRHSSQPEVYYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPQ4</accession>
    <name>C7ZPQ4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable electron transfer flavoprotein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_50378</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9 10">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040110.1">
        <property type="nucleotide sequence ID" value="XM_003040064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZPQ4"/>
    <dbReference type="FunCoup" id="C7ZPQ4">
        <property type="interactions" value="544"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZPQ4"/>
    <dbReference type="GeneID" id="9677612"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_50378"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_50378"/>
    <dbReference type="eggNOG" id="KOG3954">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034178_0_1_1"/>
    <dbReference type="InParanoid" id="C7ZPQ4"/>
    <dbReference type="OMA" id="WRPYAEQ"/>
    <dbReference type="OrthoDB" id="1715808at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000041">
        <property type="entry name" value="Electron transfer flavoprotein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000001">
        <property type="entry name" value="Electron transfer flavoprotein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 9 10" id="KW-0274">FAD</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="11">
        <location>
            <begin position="20"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="247"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="261"/>
            <end position="265"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="278"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000089-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU34397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="332" mass="34450" checksum="73A70A7625A963EA" modified="2009-10-13" version="1">MGRAHAYSLNAQARQRLLSTLAILEHKDGQLNHSSSSAFTAAKKLGGTVHGFIAGSNIKAVAEEAAKAEGVEKIIAVDNGAYDKGLPENYAPLLVENIKKGGYTHVIAGHTAFGKNLLPRVAALLDSQQISDITAIEGENTFVRPIYAGNAIATVESSDSIKVVTIRGTAFAAAALEGGSATVEEGVDPKTESPTEWVSEDLAKSDRPDLSTASRVVSGGRGLKSKEDFDKVMLPLADALGAAVGASRAAVDSGYADNSLQVGQTGKVVAPQLYMAVGISGAIQHLAGMKDSKVIAAINKDADAPIFQVADVGLVGDLFEKVPELTEKIKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQ66</accession>
    <name>C7ZQ66_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_89085</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698984">
        <property type="protein sequence ID" value="EEU33829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039542.1">
        <property type="nucleotide sequence ID" value="XM_003039496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQ66"/>
    <dbReference type="GeneID" id="9667073"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89085"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89085"/>
    <dbReference type="eggNOG" id="ENOG502SJ9I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033175_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZQ66"/>
    <dbReference type="OMA" id="ANWISHP"/>
    <dbReference type="OrthoDB" id="5229455at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF43">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="64"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU33829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="586" mass="65690" checksum="5953630BA6C3627D" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQU2</accession>
    <name>C7ZQU2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Transaminase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_10996</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="GG699012">
        <property type="protein sequence ID" value="EEU33611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039324.1">
        <property type="nucleotide sequence ID" value="XM_003039278.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQU2"/>
    <dbReference type="STRING" id="660122.C7ZQU2"/>
    <dbReference type="GeneID" id="9666845"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_10996"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_10996"/>
    <dbReference type="eggNOG" id="KOG0186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_314643_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZQU2"/>
    <dbReference type="OrthoDB" id="5464at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="10">
        <location>
            <begin position="30"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Proline dehydrogenase" evidence="11">
        <location>
            <begin position="592"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU33611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="930" mass="104177" checksum="3AC54AFAD59C271E" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQX4</accession>
    <name>C7ZQX4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_88537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699018">
        <property type="protein sequence ID" value="EEU33587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039300.1">
        <property type="nucleotide sequence ID" value="XM_003039254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQX4"/>
    <dbReference type="GeneID" id="9666818"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88537"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88537"/>
    <dbReference type="eggNOG" id="ENOG502T46S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071326_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZQX4"/>
    <dbReference type="OrthoDB" id="3546164at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU33587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="21129" checksum="856C6DA330095663" modified="2009-10-13" version="1">MPFLAIVVPTIPAEHKANVLADWPSQKAELKAQPGVLDVLAGPILIEDGVPPTDFKFFQGIIFKSAEDADAFENSSWTKERKAKFQAHGGPEPFVARFEVSEPPAHGSPKPITQFSVLEIADTSKHAQAREAFENLAKAAGKETAGGVSAGDGQKAGLGVTGWDSLEEAKAVRDDPKFAAAIAALDSLGKTHTIFVEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZRJ2</accession>
    <name>C7ZRJ2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_74386</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG699095">
        <property type="protein sequence ID" value="EEU33367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039080.1">
        <property type="nucleotide sequence ID" value="XM_003039034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZRJ2"/>
    <dbReference type="GeneID" id="9666599"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74386"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74386"/>
    <dbReference type="eggNOG" id="ENOG502SJHM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011017_2_0_1"/>
    <dbReference type="InParanoid" id="C7ZRJ2"/>
    <dbReference type="OMA" id="DEAWFAD"/>
    <dbReference type="OrthoDB" id="3862662at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF10">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="212"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="532"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU33367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="617" mass="71061" checksum="6EE15B545C6A5ADB" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHL9</accession>
    <name>C7YHL9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial</fullName>
            <ecNumber evidence="11">1.14.15.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2-methoxy-6-polyprenolphenol 4-hydroxylase</fullName>
            <ecNumber evidence="11">1.14.15.46</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">COQ6</name>
        <name evidence="13" type="ORF">NECHADRAFT_65697</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-polyprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid. Also acts downstream of coq4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-polyprenyl)phenol to 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to coq6 from NADPH via a ferredoxin/ferredoxin reductase system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)phenol + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81183"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="EC" id="1.14.15.46"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81195"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="1.14.15.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UbiH/COQ6 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.45" evidence="11"/>
    <dbReference type="EC" id="1.14.15.46" evidence="11"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054375.1">
        <property type="nucleotide sequence ID" value="XM_003054329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YHL9"/>
    <dbReference type="FunCoup" id="C7YHL9">
        <property type="interactions" value="455"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YHL9"/>
    <dbReference type="GeneID" id="9674596"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_65697"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_65697"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_8_0_1"/>
    <dbReference type="InParanoid" id="C7YHL9"/>
    <dbReference type="OMA" id="VKQMQVW"/>
    <dbReference type="OrthoDB" id="683240at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120538">
        <property type="term" value="F:2-methoxy-6-polyprenolphenol 4-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106364">
        <property type="term" value="F:4-hydroxy-3-all-trans-polyprenylbenzoate oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000021">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000245">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03193">
        <property type="entry name" value="COQ6_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018168">
        <property type="entry name" value="Ubi_Hdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010971">
        <property type="entry name" value="UbiH/COQ6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000689">
        <property type="entry name" value="UbQ_mOase_COQ6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01988">
        <property type="entry name" value="Ubi-OHases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01304">
        <property type="entry name" value="UBIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="3 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="FAD-binding" evidence="12">
        <location>
            <begin position="38"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU48662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="487" mass="52725" checksum="BE8FDA2415674A74" modified="2009-10-13" version="1">MLARRSVLGQSSFVCRSCVRQYQSQIRRASTAAQDNIYDVVCVGGGPAGLSLLTALRANPVTAGLRVALVEAQDLSKVSSFSLPPTQFSNRCSSLTPSSARYLDTIGAWQHMKRERIQDYQEMQVWDGVTGARIEFDWPPGSAADKTIAYMAENLNLTSGLLKRLNELGGVDIFDKTKVENIDLGKETEEVDLSEWPIVQLSGGHSLAARLLIGADGANSPVRTFAGINSRGWDYGRHGVVATLQLEGDGWGGEFNKIAYQRFLPTGPVAMLPLPGNHASLVWSTTPEKATLLKSLSSKDFIAIVNAAFRLSPIDIGYMHTQADGQAEEFSWRMEHTTIDAESIPQTVVGVQEGTVASFPLKLRHADTYTGERVALVGDAAHTIHPLAGQGLNQGQGDVQSLAKTIEYAVSHGQDLGTQLSLESYNSERYAANHVILGVCDKLHRLYSVESGPLVPLRSVGLRAVNAFGPLKNFFMQQASGTGIKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C7YHM9</accession>
    <name>C7YHM9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I and III subunit RPAC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_90198</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053654.1">
        <property type="nucleotide sequence ID" value="XM_003053608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YHM9"/>
    <dbReference type="FunCoup" id="C7YHM9">
        <property type="interactions" value="969"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YHM9"/>
    <dbReference type="GeneID" id="9674602"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90198"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90198"/>
    <dbReference type="eggNOG" id="KOG1521">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038421_0_1_1"/>
    <dbReference type="InParanoid" id="C7YHM9"/>
    <dbReference type="OMA" id="KKKCRAF"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07032">
        <property type="entry name" value="RNAP_I_II_AC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000003">
        <property type="entry name" value="Dna-directed rna polymerases i and iii subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033901">
        <property type="entry name" value="RNAPI/III_AC40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF13">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="8">
        <location>
            <begin position="70"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU47941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="381" mass="42536" checksum="F58EB7B8D7C58DDA" modified="2009-10-13" version="1">MHPTQQAAWRRAPDAEETARRQTVGINKETVTNISSTDYPGHHPGEDAAFTIERFREGFSVGFHQNDQFLSSFSLVGIDASLANAFRRILLAEIPTLAVENVYIENNTSVIQDEVLAHRLGLVPFKGGREGLRDFLKWYKKPEPGEDPFSGCFDYNTVRLELNVTCTVNPDASPTENDPLKAYNNAHVYARDIVFVPTGRQAEYFDGEDAIAPTNPDILIAKLRPRQTINLAMHMHKGIGADHAKFSPVATASYRLLPTITITKPILGADADKFAKCFPQGVIGLERVTAEEAAQAGSGYEGHEGETKAVVVDAMKDTVSREVLRHEEFEGKVKLGRRRDHFIFSIESTGQWDSDELFLESVKHLKLKCKKLEQQVVNMVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>C7YI00</accession>
    <name>C7YI00_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">NECHADRAFT_98894</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 15">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 15">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053717.1">
        <property type="nucleotide sequence ID" value="XM_003053671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YI00"/>
    <dbReference type="FunCoup" id="C7YI00">
        <property type="interactions" value="1210"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YI00"/>
    <dbReference type="GeneID" id="9664743"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_98894"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98894"/>
    <dbReference type="eggNOG" id="KOG1376">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015718_1_0_1"/>
    <dbReference type="InParanoid" id="C7YI00"/>
    <dbReference type="OMA" id="YMASCIL"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000008">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="16">
        <location>
            <begin position="49"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="17">
        <location>
            <begin position="248"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEU48004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="449" mass="50045" checksum="7A189FF584304467" modified="2009-10-13" version="1">MREVISINVGQAGCQIANSCWELYCLEHGIQPDGYLTEERKAQDPDQGFSTFFSETGQGKYVPRAIYCDLEPNVVDEVRTGPYRNLFHPEMMITGKEDASNNYARGHYTVGKELIDGVLDKIRRVADNCVGLQGFLVFHSFGGGTGSGFGALLMERLSVDYGKKSKLEFCVYPAPQTATSVVEPYNSILTTHTTLEHSDCSFMVDNEAIYDICRRNLGLERPNYENLNRLIAQVVSSITASLRFDGSLNVDLNEFQTNLVPYPRIHFPLVAYAPVISAAKAAHEANSVQEMTMSCFEPNNQMVKCDPRHGKYMATCLLYRGDVVPNDAHAAVATLKTKRTIQFVDWCPTGFKLGICYQAPENVPNGDLAKVSRAVCMLSNTTAIAEAWSSLSLKFDLMHSKRAFVHWYVGEGMEEGEFSEAREDLAALERDYEEVATDSLGEEELEAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIJ2</accession>
    <name>C7YIJ2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enoyl-CoA hydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_98957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054530.1">
        <property type="nucleotide sequence ID" value="XM_003054484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIJ2"/>
    <dbReference type="STRING" id="660122.C7YIJ2"/>
    <dbReference type="GeneID" id="9664648"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_98957"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98957"/>
    <dbReference type="eggNOG" id="KOG1680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_2_1"/>
    <dbReference type="InParanoid" id="C7YIJ2"/>
    <dbReference type="OMA" id="QALMCDV"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF4">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G01890)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU48817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="32981" checksum="6A3430B664D4DA56" modified="2009-10-13" version="1">MASSQSFPDSYAALDLPTLQLFHHPASSTSVTPVIVIKLHRPEARNAFTDTMCASLSEALNLISGDPRVRAVVITSSDPKNRMFCAGMDFNEEHILGKDANDHRDSGGKVSLPMYHCAKPVIVALNGSAVGVGITMTLGANIRIASRDAMVGFVFARRGFSMEGCSSFFLPRLVGTSRALHLTTTGSVYPAGHKLLDGLFSEVVAPDEVLPTALKIADDIAANVSNVSTRVMKDMIYRSVGSPEEAHLLESKIFWHLFTGKDAKEGMQSFLEKRKPNFTGNMEDNAPTAWPWWSPVDVRKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIJ5</accession>
    <name>C7YIJ5_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_30788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054531.1">
        <property type="nucleotide sequence ID" value="XM_003054485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIJ5"/>
    <dbReference type="GeneID" id="9664650"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_30788"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_30788"/>
    <dbReference type="eggNOG" id="KOG2819">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032056_3_0_1"/>
    <dbReference type="InParanoid" id="C7YIJ5"/>
    <dbReference type="OMA" id="YRKNDQK"/>
    <dbReference type="OrthoDB" id="411211at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005373">
        <property type="entry name" value="PHAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039156">
        <property type="entry name" value="PHAF1/BROMI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465:SF2">
        <property type="entry name" value="PHAGOSOME ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465">
        <property type="entry name" value="UPF0183 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03676">
        <property type="entry name" value="PHAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU48818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="513" mass="57043" checksum="6E9E3965B1C25B7C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJ52</accession>
    <name>C7YJ52_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_99017</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053920.1">
        <property type="nucleotide sequence ID" value="XM_003053874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJ52"/>
    <dbReference type="GeneID" id="9676557"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_99017"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_99017"/>
    <dbReference type="eggNOG" id="ENOG502SHMG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019691_1_0_1"/>
    <dbReference type="InParanoid" id="C7YJ52"/>
    <dbReference type="OMA" id="TCVRFEY"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052478">
        <property type="entry name" value="Metabolite_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="47"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU48207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="539" mass="60019" checksum="0563AE5816FBE976" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJA7</accession>
    <name>C7YJA7_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_75613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
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    </reference>
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        <property type="protein sequence ID" value="EEU48238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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            <end position="70"/>
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        <location>
            <begin position="139"/>
            <end position="161"/>
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            <end position="577"/>
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    <sequence length="635" mass="69275" checksum="CB54BE278468A0D3" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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            <taxon>Nectriaceae</taxon>
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            <taxon>Fusarium vanettenii</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
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                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEU48316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="348" mass="39780" checksum="573E306C9BD9AC79" modified="2009-10-13" version="1">MSLVHTFLGQSPDQLHLVNGDQVSLLDFRAYDEYVRRQQKIFNDMSASAVSPSDVGSLGKVADEIRQHKQRDRAISCIATLSGNNNNIACQATLSLVVRLMLMVEIGSLEKSFGFMHHTGRCPLPQWMESDLASLAARLFCASLPTNCSIMSIPTTFDAWSLENVAGIKIEFTDNLADHLRLANNDTQLYVFHHVAYLEYQRHISNSQNAVLPEGLAEETLKTLAILFPQSDHWSPLRSTRKKRAWLERLRVNSNRRIDSRLTCCGTPNMDDRQLSNFRFWRDRLAIIKEVYDESTPDSFSQWWHDRRNGVQWHNFWVAMVVLGLTAFFGFIQCILAAVQVYKAYHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLZ4</accession>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
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                <person name="Salamov A."/>
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                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
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    </reference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF30">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BCTRLSENSOR"/>
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    </dbReference>
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        <property type="match status" value="2"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="558"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="706"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="862"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="1209"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="119"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="893"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="1286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU46856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1374" mass="152840" checksum="2CDEABA02D9DFCB6" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7YMG5</accession>
    <name>C7YMG5_FUSV7</name>
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        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_20598</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="660122.C7YMG5"/>
    <dbReference type="GeneID" id="9671189"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_20598"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_20598"/>
    <dbReference type="eggNOG" id="KOG4839">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006646_0_0_1"/>
    <dbReference type="InParanoid" id="C7YMG5"/>
    <dbReference type="OMA" id="PHNIRYS"/>
    <dbReference type="OrthoDB" id="1922977at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="1007"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="1007"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="417"/>
            <end position="684"/>
        </location>
    </feature>
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            <end position="908"/>
        </location>
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            <begin position="924"/>
            <end position="968"/>
        </location>
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        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
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        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
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            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
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        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
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        <location>
            <begin position="378"/>
            <end position="391"/>
        </location>
    </feature>
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        <location>
            <begin position="392"/>
            <end position="404"/>
        </location>
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        <location>
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            <end position="539"/>
        </location>
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            <end position="558"/>
        </location>
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        <location>
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        </location>
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        <location>
            <begin position="597"/>
            <end position="614"/>
        </location>
    </feature>
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        <location>
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            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="855"/>
            <end position="884"/>
        </location>
    </feature>
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        <location>
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        </location>
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        <location>
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            <end position="967"/>
        </location>
    </feature>
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        <location>
            <position position="1109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU46944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1109" mass="119517" checksum="4CD07F810B1A844B" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7YMR2</accession>
    <name>C7YMR2_FUSV7</name>
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        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_35952</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
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        <property type="protein sequence ID" value="EEU46996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003052663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YMR2"/>
    <dbReference type="GeneID" id="9671241"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_35952"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_35952"/>
    <dbReference type="eggNOG" id="ENOG502SRJS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095045_1_0_1"/>
    <dbReference type="InParanoid" id="C7YMR2"/>
    <dbReference type="OMA" id="LCKEIQY"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU46996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="124" mass="13881" checksum="4AE5EEAA8AB3AA31" modified="2009-10-13" version="1" fragment="single">CVTCQCTQCRKNGGSLMAYFHQLPASGVAFTSQTTLSRYHATEGCARGFCTACGSWLFWRREAADTISMSVGTLDEDVLKRWGKLLAHAELHFWCENEIEGATDHLQGEKWKQDNEGEGAERMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNA1</accession>
    <name>C7YNA1_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_36311</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052801.1">
        <property type="nucleotide sequence ID" value="XM_003052755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNA1"/>
    <dbReference type="GeneID" id="9671333"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_36311"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_36311"/>
    <dbReference type="eggNOG" id="ENOG502RTJ4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002341_2_0_1"/>
    <dbReference type="InParanoid" id="C7YNA1"/>
    <dbReference type="OMA" id="RAFHEED"/>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Prion-inhibition and propagation HeLo" evidence="2">
        <location>
            <begin position="11"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="278"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU47088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="641" mass="72631" checksum="47A1E4F81567D6D2" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7YND7</accession>
    <name>C7YND7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_78193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052816.1">
        <property type="nucleotide sequence ID" value="XM_003052770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YND7"/>
    <dbReference type="STRING" id="660122.C7YND7"/>
    <dbReference type="GeneID" id="9664387"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78193"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78193"/>
    <dbReference type="eggNOG" id="ENOG502SNEF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030115_0_1_1"/>
    <dbReference type="InParanoid" id="C7YND7"/>
    <dbReference type="OMA" id="ESTMAIT"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="65"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU47103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="408" mass="47082" checksum="B9D393DAEDA522BC" modified="2009-10-13" version="1">MVDLIAQDRLQRERDSFIETIDESSIQRLASSYHDGDECDFFQPPKCGRFVMSYFVRFPNGDFLIAQTTIPIPRVIAPNIDEEEDADIPPFVILEYVEGTPLSDVRIQGLSVEQKATFYQDLANIYLQLRGLTFSEIGALALSDEDEVDVLQGPVSPEFNLQQLAGLQPALVREVRGPRGPVRTATEYVSILLAMSWNVFYSSPAVTQDKVDAEQTLYYLFQFDRFVRKKWFDESLDHEPFVLSHGDLVDRNIIVDDDMHIVAVLGWEWSRVVPLQLFNPPLWLVSNSPELLASRQFYQYHVEELDKFMTILRQREQAHFGGIHLADEWQDIHRNGGLLVAEALEKMDLEIIFYFGYRFCDDSQVPTTFLRQFMEDSPARVDIVASKVREGEMYDLECQHRRLGEYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNF7</accession>
    <name>C7YNF7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">O-methyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_36367</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053331.1">
        <property type="nucleotide sequence ID" value="XM_003053285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNF7"/>
    <dbReference type="GeneID" id="9671358"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_36367"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_36367"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005533_5_0_1"/>
    <dbReference type="InParanoid" id="C7YNF7"/>
    <dbReference type="OMA" id="RILINDC"/>
    <dbReference type="OrthoDB" id="2410195at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF17">
        <property type="entry name" value="O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="226"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU47618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="393" mass="43085" checksum="55241A68EC99AF20" modified="2009-10-13" version="1">MAAALIDAVASNGKVFTETGDEGARQKVIAAAAALIQELENPGEQLARIGWGEPTRTAAFRTGFELGLFKKLGDEPQSSEQLAAGTTADPVLVARILKHLAANGIVKEVGMDQYVATPFSMSTRDPTMEGGLIYSFEGMIPTFQGLPEFLAKTNYQVPKDASDGPVQYGLRTEKPFFSILKENARLGKAFNGFMTGYAKARPRWVDFYPFEERLAADDKSAEQSGPLLVDIGGGVGHELLGLNAKDNAPAGQLVLQDLPEVIEDARTTGDLPENIQAVAHDFFKPQPAEYRGARAYFMRLILHDWPDAECAVILSHIRDAMAKGYSRLLINEAVLRDVGAPWQQTSLDWTMMGMLVNRERTESQWRKLLADAGLKITGIWHKDSESVIEAMLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNM2</accession>
    <name>C7YNM2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_60402</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052310.1">
        <property type="nucleotide sequence ID" value="XM_003052264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNM2"/>
    <dbReference type="STRING" id="660122.C7YNM2"/>
    <dbReference type="GeneID" id="9670832"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_60402"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_60402"/>
    <dbReference type="eggNOG" id="KOG0955">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002663_0_0_1"/>
    <dbReference type="InParanoid" id="C7YNM2"/>
    <dbReference type="OMA" id="NTSKWSH"/>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15670">
        <property type="entry name" value="ePHD_BRPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15492">
        <property type="entry name" value="PHD_BRPF_JADE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000007">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF107">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="426"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="480"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="161"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="393"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="649"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="943"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="973"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1130"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="171"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="649"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="979"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1144"/>
            <end position="1158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU46597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1158" mass="128072" checksum="0EFEA778201F8635" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPJ9</accession>
    <name>C7YPJ9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_92531</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052022.1">
        <property type="nucleotide sequence ID" value="XM_003051976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YPJ9"/>
    <dbReference type="STRING" id="660122.C7YPJ9"/>
    <dbReference type="GeneID" id="9673250"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_92531"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_92531"/>
    <dbReference type="eggNOG" id="KOG0817">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043304_1_0_1"/>
    <dbReference type="InParanoid" id="C7YPJ9"/>
    <dbReference type="OMA" id="WMRRKKD"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF133">
        <property type="entry name" value="COA BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ACB" evidence="4">
        <location>
            <begin position="5"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU46309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="302" mass="34441" checksum="1C2A719F29D2AFC4" modified="2009-10-13" version="1">MADSVDRVFVHALNTVKKIPKTGASRPPPNDRLRLYGLYKQAMEGDVDGVMERPNAASGMAPDDLQREKDKWDAWNLQKGLSRTESKRRYVEALIDTMHRYATTPDAKELVAELEFVWNQIKHNSPSSSMSSPRANRSGGASQQHYADPPSEAEGPMKMISPMSEYDEAELRSQRQLDLEDEMEEGQEGSQRGGRWQRRVERALTTMSAEVAALREQITTGREWRAKKQRSFPAWAKWFAWLVVKHLSADFVILAIVLLWMRKRKDRRLEDLVRAALRLAREYVRKVLPSRGQPASLPGSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C7YR33</accession>
    <name>C7YR33_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras modification protein ERF4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_68612</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with ERF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052287.1">
        <property type="nucleotide sequence ID" value="XM_003052241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YR33"/>
    <dbReference type="STRING" id="660122.C7YR33"/>
    <dbReference type="GeneID" id="9673740"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_68612"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_68612"/>
    <dbReference type="eggNOG" id="ENOG502S30T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018540_1_0_1"/>
    <dbReference type="InParanoid" id="C7YR33"/>
    <dbReference type="OMA" id="WDDMGLT"/>
    <dbReference type="OrthoDB" id="5377273at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031211">
        <property type="term" value="C:endoplasmic reticulum palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051371">
        <property type="entry name" value="Ras_palmitoyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254">
        <property type="entry name" value="GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 7_ERF4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Golgin subfamily A member 7/ERF4" evidence="8">
        <location>
            <begin position="484"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="114"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="615"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="324"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU46574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="642" mass="68871" checksum="9782EF2D22A02C29" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRB5</accession>
    <name>C7YRB5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_80333</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051141.1">
        <property type="nucleotide sequence ID" value="XM_003051095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YRB5"/>
    <dbReference type="GeneID" id="9665855"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_80333"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_80333"/>
    <dbReference type="eggNOG" id="ENOG502SPW2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051118_1_1_1"/>
    <dbReference type="InParanoid" id="C7YRB5"/>
    <dbReference type="OMA" id="MVFLQIG"/>
    <dbReference type="OrthoDB" id="5416037at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF4">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="3">
        <location>
            <begin position="144"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU45428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="286" mass="32129" checksum="F997582FC36C415F" modified="2009-10-13" version="1">MLNAPSTPRNLEMSPRTSIGGWVSSEAQHGSTTQTQASTTVETPPSEEEINLKPWKFIGYKGYAEFISSDDDWFILRRFGTLNIRVALALQDEVSVLEEKLKKLDATYSQRGAPDRHNGRLRGDVEERRALIELLSDKLYKYTQEEQEYLQHGKDLICVAQKDKTPLRRLIDSSLTIRTLPIWRHKDKAVPNYDAEHVSYYSDSRMDKFASAVIAIIGVVMLITPIWVLQAMDGLKAKLGVITAFVLIFLLTLSFAMASKPFEALGATAAYAAVLMVFTQLGTPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7YS24</accession>
    <name>C7YS24_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_104536</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050884.1">
        <property type="nucleotide sequence ID" value="XM_003050838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YS24"/>
    <dbReference type="GeneID" id="9666052"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_104536"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_104536"/>
    <dbReference type="eggNOG" id="KOG2765">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025401_0_0_1"/>
    <dbReference type="InParanoid" id="C7YS24"/>
    <dbReference type="OMA" id="AVYIQHQ"/>
    <dbReference type="OrthoDB" id="10062838at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026505">
        <property type="entry name" value="Solute_c_fam_35_mem_F3/F4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
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        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
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        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
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        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
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        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
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        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
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        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
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            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
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        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU45171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="553" mass="61918" checksum="9A70E0F87A630B14" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSB3</accession>
    <name>C7YSB3_FUSV7</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">NECHADRAFT_100655</name>
    </gene>
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        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003051272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSB3"/>
    <dbReference type="GeneID" id="9668165"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100655"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100655"/>
    <dbReference type="eggNOG" id="ENOG502S606">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041168_1_0_1"/>
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    <dbReference type="OMA" id="AHIKTED"/>
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        <property type="component" value="Chromosome 5"/>
    </dbReference>
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        <property type="entry name" value="YALI0D23727P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42111:SF1">
        <property type="entry name" value="YALI0D23727P"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="183"/>
        </location>
    </feature>
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        <location>
            <begin position="304"/>
            <end position="396"/>
        </location>
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            <end position="66"/>
        </location>
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            <begin position="83"/>
            <end position="108"/>
        </location>
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            <end position="126"/>
        </location>
    </feature>
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            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU45605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="396" mass="41600" checksum="C56F0A354C4DCB9A" modified="2009-10-13" version="1">MSLAEAAPITRGDPYAPVDAADDQRLGDSTPRASDFMTEPDSQTGDAKKDPKSKKRSFFGFGKKKTPSLTKSESQNESKPESESQSEPKSQSQSQTPSHSNSAAASPPLMSRDASKLSSTAWSAPSDQAFVLPSSPGRGFSGSPRLSSPATSQIFERDVQDSTVLKPNSPAIPTHIQTENYIPPVLDDASEAITNEKLDPDTVEIVTHSSHQPAAVTVTGANNGLPLYDQSASEWAAELASFADRDAVSADNASNYGSLDSSDVRRLSFISFADVVQAEHNPPAGVASSRDSIHLAGLTSLPAAVNRSPSPIRSPVSSQGPESPPTSNPGSMKGIELSPPRKPLGSPTSTANLKLSVGGNDLNIETMSQALRRTGSTDLSNVRSHPTSPIEGSNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSR3</accession>
    <name>C7YSR3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_80823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051000.1">
        <property type="nucleotide sequence ID" value="XM_003050954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSR3"/>
    <dbReference type="GeneID" id="9668324"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_80823"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_80823"/>
    <dbReference type="eggNOG" id="ENOG502RPR4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1069605_0_0_1"/>
    <dbReference type="InParanoid" id="C7YSR3"/>
    <dbReference type="OMA" id="FRITHRV"/>
    <dbReference type="OrthoDB" id="5193943at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU45287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="254" mass="29013" checksum="EC8B18E1B3E9E803" modified="2009-10-13" version="1">MDSTNITSNGTQWPLFNKYNELPINHIYTFCIFAYFMPHMLRMMKSKGYAKAHHYHRSLLIVHSVVSVIEVVLFHVKSWHLGHDPKANNIDLFLCVVQTITSLVMTERMRFIPKLTLELSRASFQAMAFMRVLASGLALYLGSTEWHRASVKMLASFVWVRFIIIWSSKFAGINTYGQGYSLGLIGGILMGIYEGTYPHGIGIYMGTTLSLLAFDRWASKFDNPSIDMLRFVGVVSHRVEKPNEEPEKPLKKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>C7YTC4</accession>
    <name>C7YTC4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 2</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSD2</name>
        <name evidence="16" type="ORF">NECHADRAFT_69234</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit. Interacts with pstB2. This interaction may be a means to structurally tether the donor membrane (ER) harboring PstB2 to acceptor membranes (Golgi/endosomes) harboring PSD2 during PtdSer transport to the site of PtdEtn synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Golgi apparatus membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Endosome membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The C2 domains have an essential, but non-catalytic function. They may facilitate interactions with other proteins and are required for lipid transport function.</text>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="12"/>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_003051100.1">
        <property type="nucleotide sequence ID" value="XM_003051054.1"/>
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    <dbReference type="AlphaFoldDB" id="C7YTC4"/>
    <dbReference type="FunCoup" id="C7YTC4">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YTC4"/>
    <dbReference type="GeneID" id="9665743"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_69234"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_69234"/>
    <dbReference type="eggNOG" id="KOG1030">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002661_0_0_1"/>
    <dbReference type="InParanoid" id="C7YTC4"/>
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    <dbReference type="OrthoDB" id="67700at2759"/>
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        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:Golgi membrane"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0006646">
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        <property type="term" value="P:protein autoprocessing"/>
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    <dbReference type="CDD" id="cd04039">
        <property type="entry name" value="C2_PSD"/>
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    </dbReference>
    <dbReference type="CDD" id="cd04024">
        <property type="entry name" value="C2A_Synaptotagmin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000445">
        <property type="entry name" value="Phosphatidylserine decarboxylase proenzyme 2"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.60.40.150:FF:000198">
        <property type="entry name" value="Phosphatidylserine decarboxylase proenzyme 2"/>
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    <dbReference type="Gene3D" id="2.60.40.150">
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    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00663">
        <property type="entry name" value="PS_decarb_PSD_B_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
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        <property type="entry name" value="C2_domain_sf"/>
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    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
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    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
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    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033179">
        <property type="entry name" value="PSD_type2_pro"/>
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    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF17">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023317791" description="Phosphatidylserine decarboxylase 2 beta chain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023317792" description="Phosphatidylserine decarboxylase 2 alpha chain" evidence="12">
        <location>
            <begin position="1020"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="38"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="272"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="521"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="209"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="393"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="620"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1075"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="630"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="667"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1111"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="875"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="933"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="1020"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="12">
        <location>
            <position position="1020"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="12">
        <location>
            <begin position="1019"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="12">
        <location>
            <position position="1020"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEU45387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1123" mass="125124" checksum="434C6A53F22DC6C5" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7YUC5</accession>
    <name>C7YUC5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_21972</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003050054.1"/>
    </dbReference>
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        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YUC5"/>
    <dbReference type="GeneID" id="9674885"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_21972"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_21972"/>
    <dbReference type="eggNOG" id="KOG1867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008279_6_0_1"/>
    <dbReference type="InParanoid" id="C7YUC5"/>
    <dbReference type="OMA" id="NRDNSCY"/>
    <dbReference type="OrthoDB" id="2020758at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02662">
        <property type="entry name" value="Peptidase_C19F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="10">
        <location>
            <begin position="151"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="262"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="480"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="550"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="646"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="657"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU44387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="672" mass="74556" checksum="E296FB3908BA1F0D" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7YUT0</accession>
    <name>C7YUT0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Expressed protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_101713</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of a tri-snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNUT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050177.1">
        <property type="nucleotide sequence ID" value="XM_003050131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YUT0"/>
    <dbReference type="STRING" id="660122.C7YUT0"/>
    <dbReference type="GeneID" id="9665695"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101713"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101713"/>
    <dbReference type="eggNOG" id="KOG3263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075596_0_0_1"/>
    <dbReference type="InParanoid" id="C7YUT0"/>
    <dbReference type="OMA" id="VDSSTMW"/>
    <dbReference type="OrthoDB" id="21368at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013957">
        <property type="entry name" value="SNRNP27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077">
        <property type="entry name" value="U4/U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077:SF1">
        <property type="entry name" value="U4_U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08648">
        <property type="entry name" value="SNRNP27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein" evidence="9">
        <location>
            <begin position="172"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU44464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="228" mass="26879" checksum="D8BE8A12448F0202" modified="2009-10-13" version="1">MGDSRRNRRPDSRQMWDESDRRDRRGGPRDRDRDNNDRDRRGYRDRSRERRGGYRDRSRSPDRRHRDRDGDRNRPRNRGPRYHDDRRDQRRDDDDGPRYRRDDDGDRRAKPRRSASPSTRSPSHDTTSLPTRTRPDNKREQQPPNMSFNVSNKSPPRRDDAPEGDEMDAEDDEMAAMQAMMGFGGFGTTKNKKVAGNNAGGVSKEKKTEYRQYMNRQGGFNRPLSPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C7YUY0</accession>
    <name>C7YUY0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_49301</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050199.1">
        <property type="nucleotide sequence ID" value="XM_003050153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YUY0"/>
    <dbReference type="STRING" id="660122.C7YUY0"/>
    <dbReference type="GeneID" id="9674984"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_49301"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_49301"/>
    <dbReference type="eggNOG" id="KOG1311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024136_0_1_1"/>
    <dbReference type="InParanoid" id="C7YUY0"/>
    <dbReference type="OMA" id="GEFRFCK"/>
    <dbReference type="OrthoDB" id="302728at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="107"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="386"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="456"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="487"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="519"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU44486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="538" mass="60723" checksum="C3A49737F1204143" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C7YV60</accession>
    <name>C7YV60_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Essential protein Yae1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_85162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050236.1">
        <property type="nucleotide sequence ID" value="XM_003050190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YV60"/>
    <dbReference type="GeneID" id="9674673"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85162"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85162"/>
    <dbReference type="HOGENOM" id="CLU_1971119_0_0_1"/>
    <dbReference type="InParanoid" id="C7YV60"/>
    <dbReference type="OrthoDB" id="5106024at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU44523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="14182" checksum="72628AC0FD302887" modified="2009-10-13" version="1">MPQAGGFSRAVPRRRDFSSAFRRFRGARRRRAIIAAVTAAVREMFFAQETEADHNMGGSQQPPMYNDEELVDEYLRGHERGLRLGLRRGHESGYRQGLAEGFAHGLRQGQESAYVAGYNDGAAYGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7YW37</accession>
    <name>C7YW37_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_74170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU43898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049611.1">
        <property type="nucleotide sequence ID" value="XM_003049565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YW37"/>
    <dbReference type="MEROPS" id="S10.001"/>
    <dbReference type="GeneID" id="9677394"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74170"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74170"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008523_10_4_1"/>
    <dbReference type="InParanoid" id="C7YW37"/>
    <dbReference type="OMA" id="HACYREL"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006523192" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU43898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="488" mass="54615" checksum="D3021C6F2E8B0C7E" modified="2009-10-13" version="1">MKAVHLIAVIWLACCSPFGVRGEYVTIPSTLSPNYAIRAKDLTGQVCDSGSNNTVGWADLGPHHLFYWFHQARTQHLSKPLLLWLQGGPGNSGFFGNFLEHGPCRLEGNPAEAVRHEHPWTELFNVIFVDQPVNVGFSYSDDSSGVNRAEDAAIELVDFMRVFYQGYPDMRDVPLFIAGESYGGRYVPMTAAALIEFNKFQPRPGDAIPLKGIMVGNGYTSPTDVYSSGYELGCFPFKGFRNYFNSSECARFSTTLPECLDLLRACEALPGSAICYRSAEFCQGEFKFEKLRPQHSWDRRKYCDPPEKCIETSRAVTAWMNTPEIWELLEIESQTNKVRPVGVANGTVSEQFLQSGDLGESTVTALERILRYASEERTRGSGRDIDVLYYNGVTDILCTSVGNRRMLENLRWPGEGLYRASPWETLSWKTVEGVSAGQLKRADGLWYAELEDAGHLVPTDQPIVILNLLSSWLGKSLFSERVSNNDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWE3</accession>
    <name>C7YWE3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anaphase-promoting complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NECHADRAFT_9904</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RING-box family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049880.1">
        <property type="nucleotide sequence ID" value="XM_003049834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWE3"/>
    <dbReference type="FunCoup" id="C7YWE3">
        <property type="interactions" value="254"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YWE3"/>
    <dbReference type="GeneID" id="9677231"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_9904"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_9904"/>
    <dbReference type="eggNOG" id="KOG1493">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115512_0_1_1"/>
    <dbReference type="InParanoid" id="C7YWE3"/>
    <dbReference type="OMA" id="QWRWDTG"/>
    <dbReference type="OrthoDB" id="1681166at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16456">
        <property type="entry name" value="RING-H2_APC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000111">
        <property type="entry name" value="Anaphase-promoting complex subunit 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024991">
        <property type="entry name" value="RING-H2_APC11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12861">
        <property type="entry name" value="zf-ANAPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="35"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU44167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="79" mass="9063" checksum="C66842A26E1FEAB0" modified="2009-10-13" version="1" fragment="single">MKVTIKEWNTVATWRWDIPEDDVCGICQVHFDGTCPTCKYPGDSCSLLSGKCGHNFHMHCILEWIKQDSSRGQCPMCRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWH1</accession>
    <name>C7YWH1_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_29913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049892.1">
        <property type="nucleotide sequence ID" value="XM_003049846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWH1"/>
    <dbReference type="GeneID" id="9677490"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_29913"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_29913"/>
    <dbReference type="eggNOG" id="ENOG502REQX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_678014_0_0_1"/>
    <dbReference type="InParanoid" id="C7YWH1"/>
    <dbReference type="OMA" id="LCCQPLC"/>
    <dbReference type="OrthoDB" id="4819569at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU44179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="382" mass="42494" checksum="B2B4E8E19458ED20" modified="2009-10-13" version="1">MFQRVYPSQGIGYEVTCAAAGTVCRNPPTALKLNGQRITSQYCQFHACRQVEGGRACPNAKLPRAVVCSQHIRCQAVDNGTRCNLDVKDGNSALYRYCMPLHLCTLPGCEAQRTWHNGQDLAFCHEHRCEYDDCRNHKDTGPFCKDHTCDDTHCIAFAQGVDPEDPQRFCERHRHCQKPQCRRLCHVRDNGQPSPFCGAHYCEAPDCEAEREGGSHCRDHACAEQGCLEGQESPGSGYCKKHTCKTRNCRLRRLGKDYCPYHECVYGGCEAEAMEGGFLFKGQHTSYVKTATTIDEAVVDEQNEAHDSVNTIFARSVTVKTQRLLRSNSALVTSVLCQNVTDPGKLQSTDLPRAMLTDSFATDTAVDKLAATTRLRRDQAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWQ8</accession>
    <name>C7YWQ8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_95016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049416.1">
        <property type="nucleotide sequence ID" value="XM_003049370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWQ8"/>
    <dbReference type="GeneID" id="9677053"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95016"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95016"/>
    <dbReference type="eggNOG" id="ENOG502RB3M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044226_0_0_1"/>
    <dbReference type="InParanoid" id="C7YWQ8"/>
    <dbReference type="OMA" id="AHMARAY"/>
    <dbReference type="OrthoDB" id="4850726at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="155"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU43703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="375" mass="42442" checksum="DA26001A66881F14" modified="2009-10-13" version="1">MPSLEGLSLVPYRSLDPSGTEVRLLELHPASTGNINERLVCRLVHERLSDSSDFIGLSSLFGDINVTEAIHVNGTRVVLPANVAQALRYVRAVFLSPSPPTPCSSSSDLREEKRYEAPLSPPPPPKKPPGWLRSLFRGVRNAFADPSKGARPPLRIWLDTLCINRRDAREESERRSHMARAYRHAKMVVGWLGPKDSTSDLAIEIIRAWDKCMPLTFGEPGDRELHPDNYAPTLQWMGPVAHLSDIPEGITDPREVPSYKAISEFLNRPYFRNTWMLDDMTMARFPAFLLGDDIVSWMQILRLNRVNEDIKDHGADMFPDHLRHLLEYMPLGSVYTFLKEFDMRQREEGIVPMMITATSSVRSSESISALRGAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWU8</accession>
    <name>C7YWU8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_95023</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049183.1">
        <property type="nucleotide sequence ID" value="XM_003049137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWU8"/>
    <dbReference type="STRING" id="660122.C7YWU8"/>
    <dbReference type="GeneID" id="9677075"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95023"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95023"/>
    <dbReference type="eggNOG" id="ENOG502S4M8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_18_0_1"/>
    <dbReference type="InParanoid" id="C7YWU8"/>
    <dbReference type="OMA" id="MWWSTYE"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="141"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU43470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="457" mass="50240" checksum="54470B111D745B9E" modified="2009-10-13" version="1">MRIVIIGAGISGCAVYLELKKHLKGAPDITIYEAYDTARDTTAEKRGQDPTHSSTLIVGGGLAIAPNGLGVLRRLDDDLLCDITRNGYVTSHSNLKDKNGNVLMRMGPGLVSDMFSVACSRHSLWRCLRDRIPDDHIVNKRVLNVTANLQGKNIVRFVDGSDSVEADLVIGADGVRSIAKEALFPDAKDNPYPPKYEGLVGIGGFVSADDVRESVDKGSINFVFSGSGFFGYFFSESSPSDSKRDSPSHVCEPGDSLAWWSTYEIKECPDPKSLDMDDVMRQLRERHGQWKDPVVQSVLKSAHIQNMYPTWTSPELPTWERDGVVLLGDAAHTLPPTSGQGASQALEDCEAFTLFLAHSLDDISEQDDSSNLASIKQAINKAARQYMDLRQPRVRQILKAAQKMQSSKRTMGAIQEYAMYTFMKVIGFFPSIATKPTRAVIEYNVAEEVARVLGAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7YX42</accession>
    <name>C7YX42_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_82885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049478.1">
        <property type="nucleotide sequence ID" value="XM_003049432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YX42"/>
    <dbReference type="GeneID" id="9666140"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82885"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82885"/>
    <dbReference type="eggNOG" id="ENOG502S528">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069431_0_0_1"/>
    <dbReference type="InParanoid" id="C7YX42"/>
    <dbReference type="OMA" id="PFFWREL"/>
    <dbReference type="OrthoDB" id="5333917at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU43765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="360" mass="40996" checksum="681422200E57DACE" modified="2009-10-13" version="1">MSSTITHHLHTAQTRPDLWDHLLDPNHPLNTAWPYFLEQDTTLLSLSQKICDFPGLRKFQYLISERNDEGNEELVACGRSIPFFWQELRDAEKGGRLDLNPHLFQSLPDGGWDTMVARGIRQYMASHPEEAPSWPWSSAPITTDDQERDTARASSPELPNALSALAVTVRADRRRTGLAERILQKMKDTARQEGLKILVVPLRPTKKSSHPFVPMEEYITWTQAQAPLKPTICRTPSPFRLTPQATVQPITIASKDHALKSSLPFDPWLRKHVRIGAKIAKIAHKSMEVEASLDDWTAWTGIDFDSFPNAPKVREINRTSKVVEYTQVALQGGLVPLKVYKEEKRAVYVEPNVWIYHQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C7YX56</accession>
    <name>C7YX56_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_45329</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049485.1">
        <property type="nucleotide sequence ID" value="XM_003049439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YX56"/>
    <dbReference type="STRING" id="660122.C7YX56"/>
    <dbReference type="GeneID" id="9676916"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45329"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45329"/>
    <dbReference type="eggNOG" id="KOG0022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_14_1_1"/>
    <dbReference type="InParanoid" id="C7YX56"/>
    <dbReference type="OMA" id="HEGAGWV"/>
    <dbReference type="OrthoDB" id="1560166at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051903">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08278">
        <property type="entry name" value="benzyl_alcohol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF12">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="18"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU43772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="380" mass="40578" checksum="03ACA38FAA14AA13" modified="2009-10-13" version="1">MTSPTNIATEALVTEKPGDKFEMKPIILDEVRGDEVLVEMKYSGICHTDVLLQNGLIPGVEYPAIFGHEGAGIIRALGSDIKDKSLQVGDHVLLSFNVCGKCKKCVAGKPSFCHIHSPVNVGSVRLSDGSTPARLEDGRSVRSQFFGHSSFARVSVVAERSVVKCPYPESLPYYAPLGCGFQTGAGTVLNALKPDKTQTVVIFGMGSVGIAALMAAAYLQVKQLVAVDVVDDKLANAKEFGATHVVNSRTCGEGGIEAKIREITDGGADFAIDCTGLIPVIESLFGCLAPGGTATSVGVPPPNAVVRIEPQTFLLENKRYVGVVEGGSNPQKFIPELMELHRQGHFPVEKLCTVYSIKDFEKALADMRGGKVVKPIIHWD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-07-27" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYG9</accession>
    <name>DAPB_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName>Probable dipeptidyl-aminopeptidase B</fullName>
            <shortName>DPAP B</shortName>
            <ecNumber>3.4.14.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">DAPB</name>
        <name type="ORF">NECHADRAFT_47100</name>
    </gene>
    <organism>
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.</text>
            <dbReference type="EC" id="3.4.14.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">Lysosome-like vacuoles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S9B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.5"/>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048718.1">
        <property type="nucleotide sequence ID" value="XM_003048672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYG9"/>
    <dbReference type="SMR" id="C7YYG9"/>
    <dbReference type="FunCoup" id="C7YYG9">
        <property type="interactions" value="350"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YYG9"/>
    <dbReference type="ESTHER" id="nech7-dapb">
        <property type="family name" value="DPP4N_Peptidase_S9"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="C7YYG9">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="NechaT47100">
        <property type="protein sequence ID" value="NechaP47100"/>
        <property type="gene ID" value="NechaG47100"/>
    </dbReference>
    <dbReference type="GeneID" id="9665490"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_47100"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_47100"/>
    <dbReference type="eggNOG" id="KOG2100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006105_0_1_1"/>
    <dbReference type="InParanoid" id="C7YYG9"/>
    <dbReference type="OMA" id="MRTPQEN"/>
    <dbReference type="OrthoDB" id="16520at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000003">
        <property type="entry name" value="Dipeptidyl peptidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF200">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 10, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0031">Aminopeptidase</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0720">Serine protease</keyword>
    <keyword id="KW-0735">Signal-anchor</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <feature type="chain" id="PRO_0000412150" description="Probable dipeptidyl-aminopeptidase B">
        <location>
            <begin position="1"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Signal-anchor for type II membrane protein" evidence="2">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="topological domain" description="Vacuolar" evidence="2">
        <location>
            <begin position="107"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="892"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="749"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="826"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="859"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="912" mass="102536" checksum="316574CA966658A3" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYL3</accession>
    <name>C7YYL3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Insulin-induced protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_83729</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the INSIG family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048738.1">
        <property type="nucleotide sequence ID" value="XM_003048692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYL3"/>
    <dbReference type="STRING" id="660122.C7YYL3"/>
    <dbReference type="GeneID" id="9665510"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83729"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83729"/>
    <dbReference type="eggNOG" id="ENOG502S4EI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039316_1_0_1"/>
    <dbReference type="InParanoid" id="C7YYL3"/>
    <dbReference type="OMA" id="YGVITVH"/>
    <dbReference type="OrthoDB" id="205546at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025929">
        <property type="entry name" value="INSIG_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15301">
        <property type="entry name" value="INSULIN-INDUCED GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15301:SF3">
        <property type="entry name" value="PROTEIN NSG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07281">
        <property type="entry name" value="INSIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU43025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="42143" checksum="10A703035D3E20F1" modified="2009-10-13" version="1">MADDGPPLLRPIPRRPFDLSLTSPTPPDENSSPATPAPAQSVDLNNLRFLQPTPEPVSLSRPQSFLNLTSSTLFGIYSPTASNSRDRIFADRDELDTPWGTGAQTPIKRASIDEATYELLRDRSHLVRRRSSFRPVEAPSPLVPAPSPASLALRGLVLFVLGVGYGILVTTRPDSLKSLRGNMIRPAYNWAHLAFWGFAGVALGALLPWLDRVWEESFGDDGEEAVAENDGASTKDDGPSTDWALVVRAIGAFVGIVFAIVWQRKVAWASTLQVSLTLALVNPLLWWLIDRSKPGLFLSAVVGLTGSVLLLGVNPEIMPAPTHVALGNFSLGQDGDHDLPVLGGLARQETLETGVWMLSVLFCSCVCFGNIGRRLAVGPAATAKGRWAGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYM2</accession>
    <name>C7YYM2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_46920</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60876"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:60877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. NudC subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="4"/>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048740.1">
        <property type="nucleotide sequence ID" value="XM_003048694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYM2"/>
    <dbReference type="FunCoup" id="C7YYM2">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YYM2"/>
    <dbReference type="GeneID" id="9665926"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_46920"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_46920"/>
    <dbReference type="eggNOG" id="KOG3084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_0_2_1"/>
    <dbReference type="InParanoid" id="C7YYM2"/>
    <dbReference type="OMA" id="CNTRTTL"/>
    <dbReference type="OrthoDB" id="10249612at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006742">
        <property type="term" value="P:NADP+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03429">
        <property type="entry name" value="NUDIX_NADH_pyrophosphatase_Nudt13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000042">
        <property type="entry name" value="Probable NADH pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050241">
        <property type="entry name" value="NAD-cap_RNA_hydrolase_NudC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015375">
        <property type="entry name" value="NADH_PPase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049734">
        <property type="entry name" value="NudC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015376">
        <property type="entry name" value="Znr_NADH_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904:SF6">
        <property type="entry name" value="NAD-CAPPED RNA HYDROLASE NUDT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904">
        <property type="entry name" value="NUDIX HYDROLASE, NUDC SUBFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09296">
        <property type="entry name" value="NUDIX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09297">
        <property type="entry name" value="Zn_ribbon_NUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="254"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU43027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="416" mass="45295" checksum="35DBA9984B7AF2B7" modified="2009-10-13" version="1">MPADAPLSELPIIAALQDDDSMLTRRFGKEVVNYYAGGRINRYSFLRADAAFLRKAAVSPTARYLALNDLNPLVVDKKKLAYLTFDEVQSLVGPDPFGLTEDEAIQAFDSAQTKPLIVFLGMLEGENETDHIASGDHGDIKGHPYFAVDITPKGTHAEKATSFLADKEGKGLSLDKNPRAMSHNPDAAALYAQARSIVDWNARNPFCAGCGQPNLSVHAGYKRVCPSTDRKGGDSGEPRADCPTRHGVSNVCFPRTDPTMIAAVVSADGKRLLLGRQKRWPPYWYSTLAGFLEPGESIEESVRREVWEESGVRVGRVVIHSSQPWPYPASLMIGAIAQALPGEGEKITLNDKELEVAKWFEIEEVRKALETGTSPLGEAAPEGYKEGDLRLPPIQAIANRLITAVVEGFLSAAPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZC2</accession>
    <name>C7YZC2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">NhNPS7</name>
        <name evidence="7" type="ORF">NECHADRAFT_95699</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048492.1">
        <property type="nucleotide sequence ID" value="XM_003048446.1"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YZC2"/>
    <dbReference type="GeneID" id="9667741"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95699"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95699"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_60_2_1"/>
    <dbReference type="InParanoid" id="C7YZC2"/>
    <dbReference type="OMA" id="WQYVPVR"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000003">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000014">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF3">
        <property type="entry name" value="SIDEROPHORE SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="568"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1188"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="554"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU42779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1716" mass="189622" checksum="7158C437D74345DB" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZD1</accession>
    <name>C7YZD1_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_47654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048495.1">
        <property type="nucleotide sequence ID" value="XM_003048449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZD1"/>
    <dbReference type="GeneID" id="9667747"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_47654"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_47654"/>
    <dbReference type="eggNOG" id="ENOG502RJ1N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1402553_0_0_1"/>
    <dbReference type="InParanoid" id="C7YZD1"/>
    <dbReference type="OMA" id="WFLLKEM"/>
    <dbReference type="OrthoDB" id="5072679at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="208" mass="22830" checksum="F9D5403E292ABB23" modified="2009-10-13" version="1">MDVCITAQEPFSCEPMGSKPFEPVQTSQKAANDASASASAPLLLGGKSSPETSKPKELEFELITYDPSNDSSLTHPWDVASEPVRLPVGSTKSQLLNLLRTQLPVPSASAKKTGTFRLSRTIRRQKLDAATLFLTFGGVIVPLGPKEEDWHYRNAITKTDLLERTEGEWYLIKEMIAASSGSLKCYIVIHGEAPSNRKSSGWWFSSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZM2</accession>
    <name>C7YZM2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_84077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048344.1">
        <property type="nucleotide sequence ID" value="XM_003048298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZM2"/>
    <dbReference type="STRING" id="660122.C7YZM2"/>
    <dbReference type="GeneID" id="9667421"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84077"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84077"/>
    <dbReference type="eggNOG" id="ENOG502TC9C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_946958_0_0_1"/>
    <dbReference type="InParanoid" id="C7YZM2"/>
    <dbReference type="OrthoDB" id="610608at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU42631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="33065" checksum="6138399A8F897C8C" modified="2009-10-13" version="1">MASSAPSFILPLTPDWSLEDFDEFMGQPLFSAPTSQCLSSVTISGPCMPPSPFHPAKRNHNAFLLESPSYQSSEAPRSPQPKKKTVAGDINYSCPYRKRNPEVFNVRDHPTCATASFPSITMVKRHIMSTHLLSKCTEQCENCHSWFGDEKALMMHHRNGICPRHFSPSARQCDMGIDQEMEAKLRDRRAIYQVLTWRDLWMTIFPGCGEVPSPAFRPVVEGTEALEFFFRSLSGLDGPGRYRAQAMMPPSCDCDDFGEALRRVYGFVVDVQRRSGRFPDFGVETTYIGGRGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZW8</accession>
    <name>C7YZW8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_84169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048396.1">
        <property type="nucleotide sequence ID" value="XM_003048350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZW8"/>
    <dbReference type="GeneID" id="9667473"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84169"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84169"/>
    <dbReference type="eggNOG" id="ENOG502TECI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120091_0_0_1"/>
    <dbReference type="InParanoid" id="C7YZW8"/>
    <dbReference type="OMA" id="LLYGGWW"/>
    <dbReference type="OrthoDB" id="3542181at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988399" evidence="1">
        <location>
            <begin position="25"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="134" mass="14386" checksum="E30DA29816AA191E" modified="2009-10-13" version="1">MASRYTRIIFTLLAVLCLTTTTFAIPTAEQPAQTISSPTQTVAARACAVTARQNTNYNEQNPPPFNPPVTAAPTQEDALASLGWKQSTYYECRTRDGQERCGWHIPVYKAGAAERGSNLGLLVVGVAVALGVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z045</accession>
    <name>C7Z045_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1989 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_105183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048434.1">
        <property type="nucleotide sequence ID" value="XM_003048388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z045"/>
    <dbReference type="GeneID" id="9667698"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_105183"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_105183"/>
    <dbReference type="eggNOG" id="ENOG502QSJ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054069_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z045"/>
    <dbReference type="OMA" id="FMKASPV"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018959">
        <property type="entry name" value="DUF1989"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31527">
        <property type="entry name" value="RE64534P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31527:SF0">
        <property type="entry name" value="RE64534P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09347">
        <property type="entry name" value="DUF1989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1989" evidence="1">
        <location>
            <begin position="53"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="297" mass="33320" checksum="9DEFFD821363F3AF" modified="2009-10-13" version="1">MSSNGAERLKNRKPIKKPVPAYLPSPGSVLTVDKDAYTAIREAPRELIEEFLLPIRSGRAWKAPAGSIVKISTPEGPQVGDLNLWNLHNPRERFWASRTKQLHASHVSTYDRLWSNLPYMRPLATILTDSLDWYGEDEHGGRVHDLLGTRCDPYINTVLSGGQYNFQCHSNLTRAVLPYGLNEQDVHDVINIFQVTGLDEKGRYFMNPSPAEPGDHIEFLAEQDLLMALSTCPGGDLSLWGFGAASEDEMIKCCRPLKVEVYRLKDETLLQKHGWKPAEVSGYVGRHGMDVPLGEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0B3</accession>
    <name>C7Z0B3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_79830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047888.1">
        <property type="nucleotide sequence ID" value="XM_003047842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0B3"/>
    <dbReference type="GeneID" id="9671880"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79830"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79830"/>
    <dbReference type="eggNOG" id="ENOG502RS5V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_737779_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z0B3"/>
    <dbReference type="OMA" id="RIMAHIT"/>
    <dbReference type="OrthoDB" id="4984599at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU42175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="370" mass="43188" checksum="F1A6153105B69EF3" modified="2009-10-13" version="1">MESRRNSSPLYLSRSPQLHCADQWLDWFFDLRSKARTIGIWDNMDPYEPDGPDDELILPKAKSFVKLKTRLIKDAQDNNKPDPLDADILRMYDILLRETETKLAIYHERAVKEEAIRNLIMDTVHPDIYEAAMNTLPGKHTLRQHIKSIQDIYAPTSLFLQSRVNVAYRAVLDEARAGNCDPEAWVHKWRKAFTRAEEFGSPYVQGREAVSDFLTAVDAYFAPGWGLSTYGDYTDSLDNEKANMTLQTISQSFFYYINDIPARSKLDTRHTENVAQAQVIKVDMSCPCGRRNHPWEAEECSILEFAIRGYKDGRTNSFSRKRRNDILRELWKNQWGDLRLRLEKKGWDIPEAVWPRVEEGPYWLEYPPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0C2</accession>
    <name>C7Z0C2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_40249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047892.1">
        <property type="nucleotide sequence ID" value="XM_003047846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0C2"/>
    <dbReference type="STRING" id="660122.C7Z0C2"/>
    <dbReference type="GeneID" id="9667239"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_40249"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_40249"/>
    <dbReference type="eggNOG" id="ENOG502RXHN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072358_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z0C2"/>
    <dbReference type="OMA" id="FQFRFDP"/>
    <dbReference type="OrthoDB" id="5030973at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="270" mass="30090" checksum="3BDF147F9768B6CE" modified="2009-10-13" version="1">MFEGDIEGGRFHTKNNPKDPYQRREVIQRSGHGVDIRCTLIDAIHGAMSEDSDYWATLLVLQFRFDPQKRARRISEATIELTFDVSDPDGIPPEVEAVSFDGHYSFLPSKQSETVTRGGEGTVGVSYGAELGASAKWEKAVTRETEDATKIMGGKLIAGSMPPERKAKWTLLENQTLKTGVPASVRVAVRIKRMDEKMFTCLPRLKCKADRWTSLQSFFGGVPADDPVLLKPDMKPTNKLMVYDTEELGSVDLQKLSDVTFTTMILDAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0N2</accession>
    <name>C7Z0N2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_39897</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048124.1">
        <property type="nucleotide sequence ID" value="XM_003048078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0N2"/>
    <dbReference type="FunCoup" id="C7Z0N2">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="GeneID" id="9667296"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_39897"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_39897"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="InParanoid" id="C7Z0N2"/>
    <dbReference type="OMA" id="VFFMYPE"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF54">
        <property type="entry name" value="GLUCOSE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G00890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="10"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="493"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU42411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="515" mass="56230" checksum="F06C66A4FA48DC12" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0S1</accession>
    <name>C7Z0S1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_68995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048146.1">
        <property type="nucleotide sequence ID" value="XM_003048100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0S1"/>
    <dbReference type="ESTHER" id="nech7-c7z0s1">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="9667318"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_68995"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_68995"/>
    <dbReference type="eggNOG" id="ENOG502QTPE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051715_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z0S1"/>
    <dbReference type="OMA" id="WHPSYFR"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042171">
        <property type="term" value="F:lysophosphatidic acid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF29">
        <property type="entry name" value="PUMMELIG, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="57"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU42433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="332" mass="37190" checksum="F42B7DAB53C36695" modified="2009-10-13" version="1">MFNFHLSYQWLHFRRPTGPPTPVPDGLERLWVDTPEGRLELLSNTPSIVQEGRGPPIVFCHGGMGGAWVWTEYLQYFAACGIQCYAVSLRGHGESWHPSYLQMVFATPRSALAEDLVAAIEWVQVHEESEVILAGHSSGGGLSQGILGDGLVKVKALALLGAVPAYGSMGVYMNWWKLDPWFTIRLMLHGWHSNSPLSHPKLTQRAFFGDRFPLSSVIPFQRRMNRYESYLWPFSMMQPFAKGSSILRQIRNDGSSGEKVLVMAGTQDKLMTPKVTEETAEFYRAAAGEKREGVRVSFVDGAGHHLQNDVQWKESAGKLFQFYKGIESPISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1F9</accession>
    <name>C7Z1F9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_86138</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU41997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047710.1">
        <property type="nucleotide sequence ID" value="XM_003047664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1F9"/>
    <dbReference type="STRING" id="660122.C7Z1F9"/>
    <dbReference type="GeneID" id="9671495"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86138"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86138"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_1_1"/>
    <dbReference type="InParanoid" id="C7Z1F9"/>
    <dbReference type="OMA" id="AKWEIFL"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF11">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU41997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="540" mass="60481" checksum="9E16E0DBB2E4283F" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1N6</accession>
    <name>C7Z1N6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_85861</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU42031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047744.1">
        <property type="nucleotide sequence ID" value="XM_003047698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1N6"/>
    <dbReference type="STRING" id="660122.C7Z1N6"/>
    <dbReference type="GeneID" id="9671529"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85861"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85861"/>
    <dbReference type="eggNOG" id="ENOG502S9BE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_458615_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z1N6"/>
    <dbReference type="OMA" id="THTSISC"/>
    <dbReference type="OrthoDB" id="5153231at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU42031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="595" mass="69055" checksum="E20168BE9DA61872" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1W5</accession>
    <name>C7Z1W5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_85939</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU41896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047609.1">
        <property type="nucleotide sequence ID" value="XM_003047563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1W5"/>
    <dbReference type="STRING" id="660122.C7Z1W5"/>
    <dbReference type="GeneID" id="9671569"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85939"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85939"/>
    <dbReference type="eggNOG" id="KOG0714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_457824_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z1W5"/>
    <dbReference type="OMA" id="GEHVMQY"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000073">
        <property type="entry name" value="DnaJ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF10">
        <property type="entry name" value="CHAPERONE PROTEIN DNAJ A6, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU41896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="559" mass="64469" checksum="49B1F36C526876CA" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z307</accession>
    <name>C7Z307_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_8548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047463.1">
        <property type="nucleotide sequence ID" value="XM_003047417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z307"/>
    <dbReference type="STRING" id="660122.C7Z307"/>
    <dbReference type="GeneID" id="9675896"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_8548"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_8548"/>
    <dbReference type="eggNOG" id="ENOG502RJJ4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102622_1_1_1"/>
    <dbReference type="InParanoid" id="C7Z307"/>
    <dbReference type="OMA" id="KECYNNH"/>
    <dbReference type="OrthoDB" id="5362512at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF11">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="58"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU41750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="163" mass="18375" checksum="E7E58375C1C950D4" modified="2009-10-13" version="1" fragment="single">ESSMWSLARSWLDECFQGHNKCSAPQSPDFSPTRLVEIVDSTTFRVIECRSIKTSQRYVAFSHCWGEVETLKLLKVNKPRLETGISISELPQSYREAIDACIRLNFKFIWIDSLCIIQDSTDDWRAESATMMHVYGNALLTIAAAAAAESSESSLAHRDPLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z3M4</accession>
    <name>C7Z3M4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_83301</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047048.1">
        <property type="nucleotide sequence ID" value="XM_003047002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z3M4"/>
    <dbReference type="GeneID" id="9675458"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83301"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83301"/>
    <dbReference type="eggNOG" id="ENOG502T4E1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_478244_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z3M4"/>
    <dbReference type="OMA" id="RSAWVEY"/>
    <dbReference type="OrthoDB" id="4754366at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988800" evidence="3">
        <location>
            <begin position="24"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="509"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU41335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="570" mass="64423" checksum="630529E221D1184F" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z418</accession>
    <name>C7Z418_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Translocon Sec61/SecY plug domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_70864</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
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        <property type="protein sequence ID" value="EEU41238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003046905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z418"/>
    <dbReference type="FunCoup" id="C7Z418">
        <property type="interactions" value="944"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z418"/>
    <dbReference type="GeneID" id="9675601"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_70864"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_70864"/>
    <dbReference type="eggNOG" id="KOG1373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031763_2_1_1"/>
    <dbReference type="InParanoid" id="C7Z418"/>
    <dbReference type="OMA" id="PMMRQMF"/>
    <dbReference type="OrthoDB" id="420669at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005048">
        <property type="term" value="F:signal sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070843">
        <property type="term" value="P:misfolded protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3370.10:FF:000002">
        <property type="entry name" value="Transport Sec61 subunit alpha isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006341">
        <property type="entry name" value="PRK08568.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="13">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU41238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="476" mass="52189" checksum="CE5CCFB0699319BC" modified="2009-10-13" version="1">MSSLRFLDLVKPFVPFLPEVQQPETKIPFNQKLMWTALTLLIFLVMSQMPLYGIVSSDNSDPLYWLRMVIASNRGTLMELGITPIISSGMVFQLLAGTHMIDVNLDLKSDRELYQTAQKLLAFILSAGTATVYVFSGLYGPPSDLGAGIVFLLILQLVVAGMIVILLDELLQKGYGLGSGISLFIATNICESIMWKAFSPTTINTGRGPEFEGAVIALFHLLMTWPNKQRALQEAFYRQNLPNIMNLLATLAVFAAVIYLQGFRVEIPVKSSRQRGARGSYPVRLFYTSNMPIMLQSALSSNIFLISQMLYSRFSENLLVRLFGVWEAKDGSSQLHAVSGLVYYMSPPQNLKEALLDPIHMSAYIVYMLGACALFSKTWIEVSGSSPRDVAKQLKDQGLVMAGHRDQSMYKELKRIIPTAAAFGGACIGALSVSSDLMGALGSGTGTLLAVTIIYGYFEIAAKEGDLSGMKGMIMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4I1</accession>
    <name>C7Z4I1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Helicase-like transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CHR2126</name>
        <name evidence="16" type="ORF">NECHADRAFT_91099</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EEU40351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003046018.1"/>
    </dbReference>
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    <dbReference type="STRING" id="660122.C7Z4I1"/>
    <dbReference type="GeneID" id="9678170"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_91099"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_91099"/>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_2_5_1"/>
    <dbReference type="InParanoid" id="C7Z4I1"/>
    <dbReference type="OMA" id="ETTVWRL"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16509">
        <property type="entry name" value="RING-HC_HLTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF11">
        <property type="entry name" value="FAMILY HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G06590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="319"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="644"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="716"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEU40351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="884" mass="98588" checksum="8447689EAD709AAE" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4K5</accession>
    <name>C7Z4K5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_58293</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046654.1">
        <property type="nucleotide sequence ID" value="XM_003046608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4K5"/>
    <dbReference type="FunCoup" id="C7Z4K5">
        <property type="interactions" value="534"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z4K5"/>
    <dbReference type="GeneID" id="9678459"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_58293"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_58293"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_9_0_1"/>
    <dbReference type="InParanoid" id="C7Z4K5"/>
    <dbReference type="OMA" id="MHGKDVN"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001113">
        <property type="entry name" value="RNP domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="49"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="246"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="337"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="356"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU40941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="398" mass="41577" checksum="C07580ADB11C6A35" modified="2009-10-13" version="1">MTTTANTTNNLDAAVNDVANTLSNTSISKPADDKTAANEAASASAAEGRRLYIGNLAYATTEGELKDFFKSYLVESVSIPKNPRTDRPVGYAFVDLSTPTEAERAIEELSGKEILERKVSVQLARKPEPAGEKTEGANGEGSGAEGSRRRASGRGRGRGRGRGGRGARAGREGAGEKKEGEATEAVAATEDAAAAVAAPTTTEVQPLTDITNKINTDDSTKTKTQARPQRERRERGPPADGIPSKTKVMVANLPYDLTEEKLIELFKAYEPSSAKIALRPIPRFMIKKLQARGEARKGRGFGFVTLASEELQQKAVSEMNGKEIEGREIAVKVAIDSPDKTDDDHHEGAVNGQKEAAPATEAAPTAGASAPAAAAPAAAPAAADAAPAATTTTPVTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4T0</accession>
    <name>C7Z4T0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_91178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046114.1">
        <property type="nucleotide sequence ID" value="XM_003046068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4T0"/>
    <dbReference type="STRING" id="660122.C7Z4T0"/>
    <dbReference type="GeneID" id="9678495"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_91178"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_91178"/>
    <dbReference type="eggNOG" id="KOG3734">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018502_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z4T0"/>
    <dbReference type="OMA" id="WDSMRAP"/>
    <dbReference type="OrthoDB" id="3898179at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd07040">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF27">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU40401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="680" mass="72883" checksum="104B59E41E447F6E" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z517</accession>
    <name>C7Z517_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_76715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU41022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046735.1">
        <property type="nucleotide sequence ID" value="XM_003046689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z517"/>
    <dbReference type="GeneID" id="9678262"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76715"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76715"/>
    <dbReference type="HOGENOM" id="CLU_918576_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z517"/>
    <dbReference type="OrthoDB" id="5101182at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU41022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="303" mass="34277" checksum="AB6FA016E1BC6BAD" modified="2009-10-13" version="1">MHTHIRTDEMEPKESQNESAGAEPKLNPVIEQLDLVAASSRALEQVIAKAIEGDGKEKVVTTEMFENYFKMVFKMWDSTDLAPEIPKEPLNRDKRAMSVHIGTWANDAPEPVAEERKRKREGKDESAVKEAKARRLGAPARLAVSTQNPEVVKFDFRHHNLRMVSQNKVKVDYHPGMTYESAQIQLMRVLDQAEAARADEFNKRLLIALGRNRIVPFAKHGSGPGHVPTIAAEHQLGDRLFKPNLAGHRCLSRRESKSDYFVGTTVTWTWTSLTSPIRHDALHIRRSVFPFFSLGRLGSPRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z5B9</accession>
    <name>C7Z5B9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="3 6">2.1.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_32780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = 2-dehydropantoate + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the PanB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="3 6"/>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU41071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046784.1">
        <property type="nucleotide sequence ID" value="XM_003046738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z5B9"/>
    <dbReference type="FunCoup" id="C7Z5B9">
        <property type="interactions" value="194"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z5B9"/>
    <dbReference type="GeneID" id="9678315"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_32780"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_32780"/>
    <dbReference type="eggNOG" id="KOG2949">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_557875_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z5B9"/>
    <dbReference type="OMA" id="VLVWTDM"/>
    <dbReference type="OrthoDB" id="425211at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000003">
        <property type="entry name" value="3-methyl-2-oxobutanoate hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001452">
        <property type="entry name" value="PRK00311.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881:SF0">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU41071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="489" mass="52053" checksum="BC7B08608CF1968C" modified="2009-10-13" version="1">MSSVINPISRRASSLLPRLRSRPAWTLGPRPVAIGGAVQIRSSSHSPMGSPPTTQRKKVTLGTLKSLHRKGEPITVMTAHDFPSAHVADHAGMDMVLVGDSLAMVALGMEDTSEVVLEEMLLHCRSVARATKSAFTVGDLPMGTYEIGPEQALATAIRFIKQGRVQGVKLEGGKEMASTIKKITTAGIPVLGHVGLTPQRQNALGGFRVQGKTSAGAMSILEDALAIQEAGCFAMVVEAVPAEVAALITEKLSVPTIGIGAGNGCSGQVLVQVDMTGNFPPGRFLPKFVKKYGDVWGESMRAIEAYRDEVKTRQYPGPEHTYPISAEELDSFTKAVKDLDGANALFTYKKTLSVSLHLSFFLRYLTTSSNRLVALILHTSCANDGADPTGLNRTTTLSVLKLPALASAALASRGRSARTTDADMVRGRSGDAAPLAVSLSASGMGEAVCGEGEGDEVSRDGWSDIVEVDLKRLIERDYVEKRWLLDVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z5G6</accession>
    <name>C7Z5G6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hydroxymethylglutaryl-CoA synthase</fullName>
            <shortName evidence="6">HMG-CoA synthase</shortName>
            <ecNumber evidence="6">2.3.3.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">3-hydroxy-3-methylglutaryl coenzyme A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_66832</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10188"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.10" evidence="6"/>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU41096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046809.1">
        <property type="nucleotide sequence ID" value="XM_003046763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z5G6"/>
    <dbReference type="FunCoup" id="C7Z5G6">
        <property type="interactions" value="697"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z5G6"/>
    <dbReference type="GeneID" id="9678337"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_66832"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_66832"/>
    <dbReference type="eggNOG" id="KOG1393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008065_0_1_1"/>
    <dbReference type="InParanoid" id="C7Z5G6"/>
    <dbReference type="OMA" id="DDAYNWI"/>
    <dbReference type="OrthoDB" id="1269963at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000008">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000590">
        <property type="entry name" value="HMG_CoA_synt_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010122">
        <property type="entry name" value="HMG_CoA_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01833">
        <property type="entry name" value="HMG-CoA-S_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01226">
        <property type="entry name" value="HMG_COA_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="7">
        <location>
            <begin position="4"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="8">
        <location>
            <begin position="176"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="4">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU41096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="454" mass="50249" checksum="C8CBEE5FAC3D8C03" modified="2009-10-13" version="1">MAARPQNIGIKAIEIYFPSQYVEQTELEKFDGVSTGKYTIGLGQTKMSFCDDREDIYSFALTATKNLLKNYNVDPNSIGRLEVGTETLLDKSKSVKTVLMQLFGDNTNIEGVDTINACYGGTNAVFNTINWVESSAWDGRDGIVVAGDIALYAKGNARPTGGAGAVALLIGPNAPIVAEPGLRGTYMQHAYDFYKPDLTSEYPYVDGHYSINCYTKALDAAYRDYCKREAKQSTNGVTNGSDPNRTNLDRFDYLAFHSPTCKLVQKSYARLLYHDYLANADSPAFAEVAPELRDMDYEKSLTDKVVEKTFMGLTKKRFQERVNPSIQVATNVGNMYCGSVWGGLASLISVVDNKALEGKRIGLFSYGSGLAASFMSFRINGNIERISDVLDIPTRLAARRAVPPGDYDKMCDLRKQAHLQKDYTPKGEVSGIVPGTYYLTKVDDMFKREYAIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z5H4</accession>
    <name>C7Z5H4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_76867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046233.1">
        <property type="nucleotide sequence ID" value="XM_003046187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z5H4"/>
    <dbReference type="GeneID" id="9678339"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76867"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76867"/>
    <dbReference type="HOGENOM" id="CLU_1855805_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z5H4"/>
    <dbReference type="OrthoDB" id="5103111at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU40520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="138" mass="15495" checksum="34AF21491E02B702" modified="2009-10-13" version="1">MSTEGASKTSTAQPLQEQQQQQRQQNQNADSTFGSDEEILTRLKNLGLEDQISLTLLAKFKELRLQDRLYFAPPPTAHSTVEERAKAWSAEYCGYWSPSWDDSIHPYARPLPSTIPPGTECPSQRPTNSSIWGMGRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7Q8</accession>
    <name>C7Z7Q8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5071 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_79524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045445.1">
        <property type="nucleotide sequence ID" value="XM_003045399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7Q8"/>
    <dbReference type="GeneID" id="9672483"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79524"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79524"/>
    <dbReference type="eggNOG" id="ENOG502SMVK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083671_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z7Q8"/>
    <dbReference type="OMA" id="YQHFLID"/>
    <dbReference type="OrthoDB" id="2969215at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd11743">
        <property type="entry name" value="Cthe_2751_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.750">
        <property type="entry name" value="Domain of unknown function DUF5071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038692">
        <property type="entry name" value="Cthe_2751_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031837">
        <property type="entry name" value="DUF5071"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16804">
        <property type="entry name" value="DUF5071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5071" evidence="1">
        <location>
            <begin position="184"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="312" mass="34605" checksum="726CD504F05E1A5A" modified="2009-10-13" version="1">MTMKVKLTDTKHQKLASHSQTLTKDKLTMSTQDMKENTSTSVGGNGNTTDLGLLAGLDEEAFGARVPAILSSTSQAIFKSHQRKPPGTKVIRSRATEAPTVAAVSDILKSPIQDQDEFYLAWTALNEVVVDLPLEDLHHYRPALKAVSETTASDTTASHYQGATGLRSEAASLIRFMDDPAAVWTPQTKGDYVAERTLKERVKTAEEMRPHVPGLLDWLADPNWPPFRGCRAQLARFPEVTVGPIRQLIEKERGDGGWIASLLDFVDECVPVSMWEELKPTIKALVEEAKGDEDEWEVSDLARQWLERLEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8B1</accession>
    <name>C7Z8B1_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_79726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045552.1">
        <property type="nucleotide sequence ID" value="XM_003045506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8B1"/>
    <dbReference type="GeneID" id="9672453"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79726"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79726"/>
    <dbReference type="eggNOG" id="ENOG502SR63">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127786_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z8B1"/>
    <dbReference type="OMA" id="THHWRAN"/>
    <dbReference type="OrthoDB" id="10264507at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU39839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="117" mass="13307" checksum="A17821E1B3048756" modified="2009-10-13" version="1">MSSCFCCDAIRPYRPQHLDHEAKFTSFMAWVHKEESNSTPVPKVESTDLNEIHPSFAVQLVRQVNFGPLESKRYFIALSTASDAFKEVTESDLIRANFQKLNAHKNFGVTRTTGSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8W9</accession>
    <name>C7Z8W9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_100885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045171.1">
        <property type="nucleotide sequence ID" value="XM_003045125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8W9"/>
    <dbReference type="GeneID" id="9673670"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100885"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100885"/>
    <dbReference type="eggNOG" id="ENOG502RYIU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034303_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z8W9"/>
    <dbReference type="OMA" id="THLFCTI"/>
    <dbReference type="OrthoDB" id="549336at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="459" mass="51410" checksum="2EB45D724A41DF2A" modified="2009-10-13" version="1">MSAVALPRRFYSLLWLAILLAVVIFFVSFRDDAWSSIPSPPKSWRIPFTTDDGVLSSWKGSGDKGSDKGNSKSTYKGRKGDEPLRIALVESSGTHDEVAAAMLHAFGNYENSQLDAYFANQRFNMREIMDNFTLAANVTINKFDKFAGAMTSDPRPHILVSTTCEFDLDRGTDPVVDLLNHGETFLFCTIHHADRWAQGKYVSTVRGWAERGLVDFVGLSQHTLDFLVKETVPKWHSVANLTTRVIPPVYPVEVPETNPDDAISLAMQGDYSSGRRDYNGIFNHLGSVIRKANETTEDHEPEEVVLHVIGHGTKPEVPEHVKNNIFFDSGLSYPDFYALLSRSFSIIPGFASDTYYDRKASSTIPASLIAGAPIVANEELLNAYTYLPKEVTWVARPGEGEMDTIERVIADKDGFIKRRQKVRDLNKKLMADNQKNCNEWMELGEAKVKAYAEAQKQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z915</accession>
    <name>C7Z915_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase family 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_44020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU38943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044656.1">
        <property type="nucleotide sequence ID" value="XM_003044610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z915"/>
    <dbReference type="STRING" id="660122.C7Z915"/>
    <dbReference type="GeneID" id="9673064"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_44020"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_44020"/>
    <dbReference type="eggNOG" id="KOG1111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_23_0_1"/>
    <dbReference type="InParanoid" id="C7Z915"/>
    <dbReference type="OMA" id="HTNFPQY"/>
    <dbReference type="OrthoDB" id="512920at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03814">
        <property type="entry name" value="GT4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050194">
        <property type="entry name" value="Glycosyltransferase_grp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45947">
        <property type="entry name" value="SULFOQUINOVOSYL TRANSFERASE SQD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45947:SF3">
        <property type="entry name" value="SULFOQUINOVOSYL TRANSFERASE SQD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="482"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="4">
        <location>
            <begin position="40"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="3">
        <location>
            <begin position="240"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU38943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="523" mass="58255" checksum="41826C425E2664F7" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z931</accession>
    <name>C7Z931_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription factor SWI6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_43756</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Transcription factor that plays a role downstream of the MCK1-MKK2-MPS1 cascade. Required for hyphal morphogenesis and pathogenicity. Is an important oxidative stress response regulator and plays a positive role in the regulation of extracellular peroxidases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045061.1">
        <property type="nucleotide sequence ID" value="XM_003045015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z931"/>
    <dbReference type="FunCoup" id="C7Z931">
        <property type="interactions" value="538"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z931"/>
    <dbReference type="GeneID" id="9673499"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_43756"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_43756"/>
    <dbReference type="eggNOG" id="ENOG502QPWC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009666_1_1_1"/>
    <dbReference type="InParanoid" id="C7Z931"/>
    <dbReference type="OMA" id="HHIAMMA"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000001">
        <property type="entry name" value="APSES transcription factor (MbpA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000365">
        <property type="entry name" value="Start control protein cdc10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF3">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0183">Conidiation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="10">
        <location>
            <begin position="26"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="365"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="512"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="186"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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        </location>
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        <location>
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            <end position="684"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
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            <begin position="204"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="668"/>
            <end position="684"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU39348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="795" mass="86497" checksum="030A9C19A9625A92" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZA05</accession>
    <name>C7ZA05_FUSV7</name>
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        <recommendedName>
            <fullName evidence="8">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_21098</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZA05"/>
    <dbReference type="FunCoup" id="C7ZA05">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZA05"/>
    <dbReference type="GeneID" id="9672083"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_21098"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_21098"/>
    <dbReference type="eggNOG" id="KOG1396">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006633_0_1_1"/>
    <dbReference type="InParanoid" id="C7ZA05"/>
    <dbReference type="OMA" id="EFFCPVS"/>
    <dbReference type="OrthoDB" id="266334at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045120">
        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF0">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="652"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="8">
        <location>
            <begin position="168"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="83"/>
        </location>
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            <end position="129"/>
        </location>
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        <location>
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            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="704"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="617"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
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        </location>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        <location>
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            <end position="538"/>
        </location>
    </feature>
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        <location>
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            <end position="754"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="803"/>
            <end position="812"/>
        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU39596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="812" mass="88197" checksum="BB635CF461BE726C" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAC4</accession>
    <name>C7ZAC4_FUSV7</name>
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        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_43279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045366.1">
        <property type="nucleotide sequence ID" value="XM_003045320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAC4"/>
    <dbReference type="STRING" id="660122.C7ZAC4"/>
    <dbReference type="GeneID" id="9672321"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_43279"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_43279"/>
    <dbReference type="eggNOG" id="ENOG502S8TM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002639_4_2_1"/>
    <dbReference type="InParanoid" id="C7ZAC4"/>
    <dbReference type="OMA" id="THTPIRM"/>
    <dbReference type="OrthoDB" id="5347061at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF9">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="108"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU39653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="295" mass="33299" checksum="6F160DA1071FF715" modified="2009-10-13" version="1">MNFAPTKPWSSLLSQVTPRIPKIIILNCLLTLYKGSLGPGPAVGPAKKLPAEFTLRDATLISDWLEDCETNHAMCKQATYKLPACVLFVGSDDRLPHLYESRNEEVRYTALSHCWGAEEHRSPTTTNKSLAQRKEGIEWSELPPTFADAMAVTRLLGIDYIWIDSLCIIQDDADDWTRESTKMINVYQQAVLTISADGVLNSKAGLFHTVSQRATDEPKKMSWTNGSQENILYTRLTTVPPKSICIHSAAMSNIQDNPLRGRAWTLQEWLVSSRVVYFTKGELVWECKRFNRCEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAL1</accession>
    <name>C7ZAL1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_94727</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045007.1">
        <property type="nucleotide sequence ID" value="XM_003044961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAL1"/>
    <dbReference type="STRING" id="660122.C7ZAL1"/>
    <dbReference type="GeneID" id="9672364"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94727"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94727"/>
    <dbReference type="eggNOG" id="ENOG502QVYJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010170_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZAL1"/>
    <dbReference type="OMA" id="HREETMH"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF9">
        <property type="entry name" value="TAH-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="262"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU39294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="581" mass="64861" checksum="B13C9EB02937B3C5" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAU7</accession>
    <name>C7ZAU7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_82988</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044350.1">
        <property type="nucleotide sequence ID" value="XM_003044304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAU7"/>
    <dbReference type="STRING" id="660122.C7ZAU7"/>
    <dbReference type="GeneID" id="9672783"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82988"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82988"/>
    <dbReference type="eggNOG" id="ENOG502T32B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067163_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZAU7"/>
    <dbReference type="OMA" id="HEYPDLE"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU38637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="249" mass="28735" checksum="D71DE3F1774A0FE4" modified="2009-10-13" version="1">MDAQRITDVYRFQGRCAFNVDFQHKEFRVCWTGSWLKPPSLDEFPSSTEQTGATIEQIQHSSAVDAIWSRSRAIAHGANSHIRLFVDSLDDFPICKVAIDNRQREMIADEFSLLRHLAAMQPKARAVRTSTEPLQDEDGIFGFRMMKLKPVTHDEVSKYYHDVLEVLRHVHDAGVVHYDLSWTNIMLDQDGQVTLIDFGHAGLSEADIPLHKRRKSTRDSHQKYLASYDLEVLKTLQRYESILQHDDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAX4</accession>
    <name>C7ZAX4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_21662</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044510.1">
        <property type="nucleotide sequence ID" value="XM_003044464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAX4"/>
    <dbReference type="GeneID" id="9670805"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_21662"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_21662"/>
    <dbReference type="eggNOG" id="KOG0773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008497_2_0_1"/>
    <dbReference type="InParanoid" id="C7ZAX4"/>
    <dbReference type="OMA" id="YEGCSII"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="15"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="17"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="70"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="461"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU38797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="633" mass="71038" checksum="6600CC63F5014A78" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZB56</accession>
    <name>C7ZB56_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_83213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044462.1">
        <property type="nucleotide sequence ID" value="XM_003044416.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9672765"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83213"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83213"/>
    <dbReference type="eggNOG" id="ENOG502QQIR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000570_2_1_1"/>
    <dbReference type="InParanoid" id="C7ZB56"/>
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    <dbReference type="Proteomes" id="UP000005206">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HATPase_C_sf"/>
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        <property type="entry name" value="HET"/>
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        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
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        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="1602"/>
            <end position="1741"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="2106" mass="238754" checksum="1E825BB96A416E20" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBG6</accession>
    <name>C7ZBG6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_83173</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044567.1">
        <property type="nucleotide sequence ID" value="XM_003044521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBG6"/>
    <dbReference type="STRING" id="660122.C7ZBG6"/>
    <dbReference type="GeneID" id="9670761"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83173"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83173"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_10_0_1"/>
    <dbReference type="InParanoid" id="C7ZBG6"/>
    <dbReference type="OMA" id="HYWMAVQ"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="36"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU38854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="466" mass="50956" checksum="3187D82629F0CF72" modified="2009-10-13" version="1">MVVEADSLRKAGFKGDIIDASSSEFTDASKRFSAIFNAKAKLIAFPGTAEDVSTAVLFAGRTNLPLAVKCGGHHAGGASAVDNGLVIDLSHLKGVKINKERSEVTVAGGCLWGEVYTALRDEGLACVGGGVHNVGVGGHLLGGGYGPLTQRYGMACDNLVSATVVLANGKIVQASDKQNPDLFWGIKGASSNFGIAVELVLKTFPDPGQWVFRSLAFSPDDMPTLVPRFVQHVNAYQLNGDVVIVFLNFVRGPGNKPLVLLNFTLQGTVDQFSDIFSFFLDGMKPLNDSLTTFPSLVELSHCLDDLLLDGPPRIATGALPVTNITPTLVYKLWERWLEYTDRYSDASFTKVVFEMHKAKRVRPEASCIRAADQGHSMILISEEHNDPSHDTTALQWVHEGNQLVRQQQIQDWGKDLGVWANASMPTETAEDCWGQNYPRLQKLKAKYDPGYLFDKYWHIEPSYAHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBY2</accession>
    <name>C7ZBY2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_88588</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698916">
        <property type="protein sequence ID" value="EEU38444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044157.1">
        <property type="nucleotide sequence ID" value="XM_003044111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBY2"/>
    <dbReference type="GeneID" id="9670548"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88588"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88588"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_0_1"/>
    <dbReference type="InParanoid" id="C7ZBY2"/>
    <dbReference type="OMA" id="INNVFRM"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU38444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="37600" checksum="2046C125883F3386" modified="2009-10-13" version="1">MNSQRVTNELLDKRGARYISRQNLPMPGDVASGGKRVVFMPYGNLWKWERKVIHETIGPGNRNVFAPLQDVESRALLYLYLAEPDLWNQAHARYASSLIMSMVFGRRTKLGDPNIDRIIDTNNEIMKIFKPGSNLIDSFPFLASTGIPLPRSIQPWRNFAEEFEGLAERQRQGKDVTCFVSEFQRLGRDKTLGYESTDDSFEGYNLPAGTNVIWNSWGVHMDASEYEQPERFWPERFLNEDLDKPIKGHLAFGAGRRVCPGWVIASNSLHLLIARVMYCFDFHTVPGHLIPVGRPFEIGTEKPYEVKVTVRSPAHAALVRRECSEAANIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZC02</accession>
    <name>C7ZC02_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_88607</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698916">
        <property type="protein sequence ID" value="EEU38453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044166.1">
        <property type="nucleotide sequence ID" value="XM_003044120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZC02"/>
    <dbReference type="GeneID" id="9670559"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88607"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88607"/>
    <dbReference type="eggNOG" id="KOG3105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035169_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZC02"/>
    <dbReference type="OMA" id="TICHETE"/>
    <dbReference type="OrthoDB" id="5427804at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="101"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="3">
        <location>
            <begin position="523"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU38453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="581" mass="67705" checksum="2C106D8177AA1A4F" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDL5</accession>
    <name>C7ZDL5_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_88325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043676.1">
        <property type="nucleotide sequence ID" value="XM_003043630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZDL5"/>
    <dbReference type="STRING" id="660122.C7ZDL5"/>
    <dbReference type="GeneID" id="9669877"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88325"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88325"/>
    <dbReference type="HOGENOM" id="CLU_1402795_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZDL5"/>
    <dbReference type="OrthoDB" id="4107844at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU37963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="194" mass="22162" checksum="FFCC63B95AD59FD3" modified="2009-10-13" version="1">MKHGQWSPSQDFPMRLSCLQPSRVKRGIVAEVIVMMEVMVALISDLDGQETTHKRQLFLQFKSVSKKYPSKEAAAASEANMVMSENVISSSIGNYESKEVIVSLIQRDINFFPPPVPSHDGLLERSSFLLERLNGIAHHAKAELVKFLRDWTLTRHRQTTQGKLQQINFTATRCRHDEKQPIRAQRNLIPALKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZE80</accession>
    <name>C7ZE80_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_53357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698921">
        <property type="protein sequence ID" value="EEU37586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043299.1">
        <property type="nucleotide sequence ID" value="XM_003043253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZE80"/>
    <dbReference type="GeneID" id="9669109"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_53357"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_53357"/>
    <dbReference type="eggNOG" id="ENOG502STNI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120569_1_1_1"/>
    <dbReference type="InParanoid" id="C7ZE80"/>
    <dbReference type="OMA" id="GVAMIYF"/>
    <dbReference type="OrthoDB" id="3830014at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="5"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="106" mass="11781" checksum="9F77BF6404BCB06C" modified="2009-10-13" version="1">MAGQITRVTLFKIPKEEDQQQLLDLYKEMPQKATKDGKPYIVSVKAGKAAPDQRAQGFTVVALSTFSSIDDFNYYDTECAAHGDLKKFAKTVNQGVAMVFFENVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZET5</accession>
    <name>C7ZET5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_51371</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043060.1">
        <property type="nucleotide sequence ID" value="XM_003043014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZET5"/>
    <dbReference type="GeneID" id="9665324"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51371"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51371"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="InParanoid" id="C7ZET5"/>
    <dbReference type="OMA" id="WCIFFIP"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF38">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="12"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU37347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="521" mass="57193" checksum="EA448EE05EB59B50" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZF36</accession>
    <name>C7ZF36_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_86377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043210.1">
        <property type="nucleotide sequence ID" value="XM_003043164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZF36"/>
    <dbReference type="GeneID" id="9665315"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86377"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86377"/>
    <dbReference type="HOGENOM" id="CLU_1205060_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZF36"/>
    <dbReference type="OrthoDB" id="2562973at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU37497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="230" mass="25644" checksum="526CED5672BC73B9" modified="2009-10-13" version="1">MVIPCGCDSDFQTIKVDGKIISTAITLHRFDLPLELGKNEDDLYLKAPFPRFEALDNPQGMSLVLSSAATDDPFLTKLKLREPSAPGGSEEVADSLFDPTVRLYFVPANGQSEAYKYMDVVFKDDTYARLTELRTKYKVPVAQTGYDTSRQVISHVTNTFMKQFGNIFNAARHSSPGDVLKEVAFKGAMMQVLAGLTLVFLGQSRWIFDEVGGNLVKRERASRYQCLPMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFN3</accession>
    <name>C7ZFN3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_37173</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698923">
        <property type="protein sequence ID" value="EEU37299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043012.1">
        <property type="nucleotide sequence ID" value="XM_003042966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFN3"/>
    <dbReference type="GeneID" id="9665123"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_37173"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_37173"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="InParanoid" id="C7ZFN3"/>
    <dbReference type="OMA" id="QEPIHED"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU37299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="47397" checksum="65169C09AF77C828" modified="2009-10-13" version="1">MNTDLGSGEKSPPADVEPARQPALLPDEGSEDSESDKYLHGMPLILMALSLMIGVLTVALDNSIISTAIPKMTSEFNSLSDVRLYCGSMIIITQIVEMRKRPLFLGIITLGGLTGAIICFYYPSTLGGAVNKDRPLKQKILGLGLKSAVILTATLVCLFLALQWGGTVYPWRDSRVWGCLLGFGFLLILFSYIQVRQKEDALIPLRILSQRSVLLGCLFSCLLQGAMMTQAYHLPFYFQAVKGDDPQESGINILPHGVTVSIATLISGTAMTLSGYYVPFMWFGAALFTTGGGLLYTLSQSSPIGRWFGFQLMAGAGYGTTVQIPIFAIQVVLSTADIPLGTTMVIIAQSFGGAVGLAIAQNVFQNYLSQELNKIQGIDVAAVVAAGGVELEKVVRSGSLAMVRNAFQVAIANAFLVAVGLGGVAFLVSLGMERKRINKSKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFP1</accession>
    <name>C7ZFP1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_37158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698923">
        <property type="protein sequence ID" value="EEU37205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042918.1">
        <property type="nucleotide sequence ID" value="XM_003042872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFP1"/>
    <dbReference type="STRING" id="660122.C7ZFP1"/>
    <dbReference type="GeneID" id="9665128"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_37158"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_37158"/>
    <dbReference type="eggNOG" id="ENOG502SM08">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040048_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZFP1"/>
    <dbReference type="OMA" id="WYTISDL"/>
    <dbReference type="OrthoDB" id="165382at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU37205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="42260" checksum="B249399DD98753E9" modified="2009-10-13" version="1">MSSEIGIEEYRQDVLRVCSYHRTDFARAVVRTRPHKMQVIAPLLRNHFNNPSPFKHGPPFRLGVLDLLTPELLVIILLQLDVVSYLQFRRVNRHARVVATLLHEYKLVSAHGLEGLVALLRTKLAEFFTIKDLYRPLVTYSCKLCGGFGCFLFLPDCTRCCLPCLTEAPELRMTIVSSLVNQFLPVEGLTEYHQSQLGPVLHTVRGKYCLQHFRAVRLGEQLMPTRQVITILRSLDVPEKSIEKAVYRLRDWESNRFGSAAMYPWYNAQRGEAERGVNCKAIQFYIEENTPPHILRSACHRVHRDQIFSRASFLQHFKTCSHAQDLWARRDDGTPEKESWFISDGGYLRNEDEDEVVIVAARPSMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFZ7</accession>
    <name>C7ZFZ7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Pectinesterase</fullName>
            <ecNumber evidence="4 11">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_106465</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in maceration and soft-rotting of plant tissue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n methanol + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pectinesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="4 11"/>
    <dbReference type="EMBL" id="GG698924">
        <property type="protein sequence ID" value="EEU36967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042680.1">
        <property type="nucleotide sequence ID" value="XM_003042634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFZ7"/>
    <dbReference type="STRING" id="660122.C7ZFZ7"/>
    <dbReference type="GeneID" id="9664795"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_106465"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_106465"/>
    <dbReference type="eggNOG" id="ENOG502QSQ4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012243_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZFZ7"/>
    <dbReference type="OMA" id="TIIWINS"/>
    <dbReference type="OrthoDB" id="2019149at2759"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000014">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033131">
        <property type="entry name" value="Pectinesterase_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF127">
        <property type="entry name" value="PECTINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00503">
        <property type="entry name" value="PECTINESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012790913" description="Pectinesterase" evidence="12">
        <location>
            <begin position="16"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="13">
        <location>
            <begin position="33"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU36967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="329" mass="35071" checksum="81A7F87EE857AAA6" modified="2009-10-13" version="1">MKFLATLNFVTAAFAASRTSAPSGCLTVKKSPSSGQYGTIQAAVNALSTSASGSQCIFIDQGTYNEQVLVPKRSAQLTIYGYTADTSSYSGNKVTITAKKSQADGLNNDESATLRVKSSNFKLYNVNVANTYGKGSQAVALSAYADSGYYGCALTGYQDTLLSNEGYQLYSKCLIQGATDFIFGQKASSWFEKCDLRVVSASIGYITANGRDSSSNPSYYVFNNCNIAAASGNSVTNGAYYLGRPWREYARVVFQKTSMTSVINAAGWKVWNSGDERTGNVIFGEYSNTGAGASGKRASFYTKLSSAVSISTVLTGSYASKGYYDASYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZG42</accession>
    <name>C7ZG42_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_86687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698924">
        <property type="protein sequence ID" value="EEU37100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042813.1">
        <property type="nucleotide sequence ID" value="XM_003042767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZG42"/>
    <dbReference type="GeneID" id="9664843"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86687"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86687"/>
    <dbReference type="eggNOG" id="ENOG502T1D5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135765_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZG42"/>
    <dbReference type="OMA" id="ATMHGNK"/>
    <dbReference type="OrthoDB" id="3358750at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39475">
        <property type="entry name" value="CONIDIATION-SPECIFIC PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39475:SF1">
        <property type="entry name" value="CONIDIATION-SPECIFIC PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="118" mass="12963" checksum="2F5EC1667B777728" modified="2009-10-13" version="1">MPHGSNVGYPQSYDSGDQQHYSSAAVHKEGNMHQINTDGYLDKNKIMNELAEKDIQDHVKERMKHEPGFAAMRNGHKPSRGAMVDAEIAKEEAEMLAAKRKSKKGSMGSISSSGSMSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZH59</accession>
    <name>C7ZH59_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_51633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698927">
        <property type="protein sequence ID" value="EEU36581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042294.1">
        <property type="nucleotide sequence ID" value="XM_003042248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZH59"/>
    <dbReference type="GeneID" id="9669553"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51633"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51633"/>
    <dbReference type="eggNOG" id="KOG2317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_7_2_1"/>
    <dbReference type="InParanoid" id="C7ZH59"/>
    <dbReference type="OMA" id="FNIAWDE"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF42">
        <property type="entry name" value="MMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU36581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="129" mass="14080" checksum="B580FF044B5FEE39" modified="2009-10-13" version="1">MSYREPVVTSAACAPLPQFSQAVKFNGMVYCSGTIGIDPETDELVSGTVTDRARMALKNLQAVLEAAGSGMDRVVKANIFLANMKDFDAVNIAWDEFFPKDPKPCRTCVAVHQLPLDTDVEIEMTASYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZIQ8</accession>
    <name>C7ZIQ8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_53061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698931">
        <property type="protein sequence ID" value="EEU36070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041783.1">
        <property type="nucleotide sequence ID" value="XM_003041737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZIQ8"/>
    <dbReference type="STRING" id="660122.C7ZIQ8"/>
    <dbReference type="GeneID" id="9674173"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_53061"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_53061"/>
    <dbReference type="eggNOG" id="KOG1432">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019692_1_1_1"/>
    <dbReference type="InParanoid" id="C7ZIQ8"/>
    <dbReference type="OMA" id="HIVPMEY"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07383">
        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF11">
        <property type="entry name" value="METALLOPHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988141" description="Calcineurin-like phosphoesterase domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="42"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU36070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="434" mass="47752" checksum="0CA589616C4B2D00" modified="2009-10-13" version="1">MASRTLAVASSLFALSHAASIPRAVNNDNLPALKFTSNGTFQIAVFSDMHFGQRPAQDAKSVQVISDVLDYELPDLVVLNGDLINGDSTFKHNSTHYIDQIVAPIIDRNLTWASTYGNHDHNYYITGEGILEREQMWPGARTKSMVDDDDAGTSNYYLPVYASNCTNTNKCTPELLLWFFDSRGGRYYEADDQENWVDESVVTWFNETNTELVNKYNKVIPALAFVHIPINATMSIQTEVGIDENKQPGLNLDPPVAQQGEGWCANGTRDTDNCHYGGQDKPFTKALVTIPGIIGLFFGHDHGNTWCYRWEGSLPGVEVEGNGLNLCYGQHSGYGGYGDWIRGAREIIVSQDKLADKIIDTHIRLESGDIVGAVTLNSTYNEDSYTATPDTKTYLSDTGDLSNAEEMSAGVSLTPEFLYAAVGGSLVTMAYLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKI1</accession>
    <name>C7ZKI1_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_86163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698940">
        <property type="protein sequence ID" value="EEU35408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041121.1">
        <property type="nucleotide sequence ID" value="XM_003041075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKI1"/>
    <dbReference type="GeneID" id="9675690"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86163"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86163"/>
    <dbReference type="eggNOG" id="KOG2317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_7_0_1"/>
    <dbReference type="InParanoid" id="C7ZKI1"/>
    <dbReference type="OMA" id="MSDYTAM"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF58">
        <property type="entry name" value="PROTEIN HMF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988923" evidence="2">
        <location>
            <begin position="23"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU35408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="154" mass="16005" checksum="4524696DFAFD0F58" modified="2009-10-13" version="1">MIGMTLLKTTTLVLAAVGAVFAAPSPALQARSKSPITHLGNKGPILSGGVATKDLVYTSGTVPSVNGTIPEGIEAQVAAVIDNISLILEEAGTSWEYAIKTTVFLANMDDFAAMNAVYGRMLPDPKPARTTIQAGKLPGDFLVEIEAIVAQPHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKN5</accession>
    <name>C7ZKN5_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_86215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698940">
        <property type="protein sequence ID" value="EEU35472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041185.1">
        <property type="nucleotide sequence ID" value="XM_003041139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKN5"/>
    <dbReference type="STRING" id="660122.C7ZKN5"/>
    <dbReference type="GeneID" id="9675715"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86215"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86215"/>
    <dbReference type="eggNOG" id="ENOG502RPYW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039525_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZKN5"/>
    <dbReference type="OMA" id="CARMERY"/>
    <dbReference type="OrthoDB" id="5220943at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="481" mass="53289" checksum="3BF2BC7E3E55B80A" modified="2009-10-13" version="1">MSQSPGAAVPDTMNSTAPVAPAVPTAAMPMPGGALQTELLDALDGHASLMDKTAIRAVVAGTVAYDTLKGEATWLAIPTETEGKIPGVYVVGMSRQGQQGQFLDIDETEKLVDGLERYAKGARICIEHRRVTGSTSMTAEDEVLVEWVRTVDSLVGSVVAPDALPTPRFIQRDNEFLGMERVTEMFKRRCNRALDPSGKVRQIQSPLYVGCSKDLRTWTGAYERSARKDLADVNEPLCLVVSILEALNLPVDLSVQVAIRIWEADQLNLAEQLITTIAFSFVHQSGFNTTECGGTRSFTVDPTSAGLRQSAELLMAHSNTMEQNLRATLANIAQRRKFLDDVDRITDRLKTLNKAVREATPKEEFFGGRTYEEVKQIMAEKKQKLRDRIDQVRRENQQMELLNNILAIRAGRKVPLVNGLLEEEGEGGEEVPAYFGDYGHVTPRSGVARERHENRNIIALKMCIKDYVSSPHCYMRKIVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLQ2</accession>
    <name>C7ZLQ2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Glycoside hydrolase family 31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">NECHADRAFT_70633</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glucosidase involved in the degradation of cellulosic biomass. Has both alpha- and beta-glucosidase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698946">
        <property type="protein sequence ID" value="EEU35070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040783.1">
        <property type="nucleotide sequence ID" value="XM_003040737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLQ2"/>
    <dbReference type="STRING" id="660122.C7ZLQ2"/>
    <dbReference type="GeneID" id="9679184"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_70633"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_70633"/>
    <dbReference type="eggNOG" id="KOG1065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000631_11_0_1"/>
    <dbReference type="InParanoid" id="C7ZLQ2"/>
    <dbReference type="OMA" id="FNYPNDP"/>
    <dbReference type="OrthoDB" id="5839090at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000089">
        <property type="entry name" value="Alpha-glucosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1760:FF:000005">
        <property type="entry name" value="Putative alpha-glucosidase AgdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF67">
        <property type="entry name" value="ALPHA_BETA-GLUCOSIDASE AGDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 14 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002989277" evidence="16">
        <location>
            <begin position="20"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="18">
        <location>
            <begin position="124"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="17">
        <location>
            <begin position="282"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="19">
        <location>
            <begin position="751"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="451"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="471"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EEU35070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="954" mass="107217" checksum="D560DA15BA9BDCF9" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLQ8</accession>
    <name>C7ZLQ8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_82473</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698946">
        <property type="protein sequence ID" value="EEU35073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040786.1">
        <property type="nucleotide sequence ID" value="XM_003040740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLQ8"/>
    <dbReference type="STRING" id="660122.C7ZLQ8"/>
    <dbReference type="GeneID" id="9679187"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82473"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82473"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_6_3_1"/>
    <dbReference type="InParanoid" id="C7ZLQ8"/>
    <dbReference type="OMA" id="PVPNCKH"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF138">
        <property type="entry name" value="DEHYDROGENASE PKFF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002989395" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="6">
        <location>
            <begin position="18"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="8">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="575"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="619"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="156"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="574"/>
            <end position="575"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU35073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="652" mass="70041" checksum="A25AD121861AEAEE" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLS6</accession>
    <name>C7ZLS6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_67928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698947">
        <property type="protein sequence ID" value="EEU35011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040724.1">
        <property type="nucleotide sequence ID" value="XM_003040678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLS6"/>
    <dbReference type="STRING" id="660122.C7ZLS6"/>
    <dbReference type="GeneID" id="9679169"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_67928"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_67928"/>
    <dbReference type="eggNOG" id="KOG2865">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_6_4_1"/>
    <dbReference type="InParanoid" id="C7ZLS6"/>
    <dbReference type="OMA" id="PEDQFTN"/>
    <dbReference type="OrthoDB" id="275457at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05271">
        <property type="entry name" value="NDUFA9_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000358">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 39 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF11">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="50"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="375" mass="42685" checksum="1DB49DDBC7310278" modified="2009-10-13" version="1">MVSPLLAARSARNVALNVTGKRFLSDISITRTGKPIIRVEGGRSSLGGHTVTVFGATGQLGRYIVNRLARQGCTVVIPYREEMTKRHLKVTGDLGRVVFVEHDLRNTPSIEASVRHSDAVFNLIGRDYPTKNFSLEDVHIEGTERIIEAVAKYDVDRYIHVSSHSANSQSTSEFYRTKGRAEEIAREVFPETTIVRPAPIFGFEDNLLLKLAGVTNLFTSNNMQEKFYPVHSIDLGAALEKIFYDDTTAGQTFELYGPKQYSMREIADMVDKEIYKQRRHINVPKAILKPVAEILNKVLWWHTLSADEVEREYMDQVIDPEAKTFKDLGIEPGDIANFTYHYLQGFRSQNFYDLPPATEKEKREEKKYIHVLDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLV2</accession>
    <name>C7ZLV2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_59655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S14 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698947">
        <property type="protein sequence ID" value="EEU35000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040713.1">
        <property type="nucleotide sequence ID" value="XM_003040667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLV2"/>
    <dbReference type="FunCoup" id="C7ZLV2">
        <property type="interactions" value="1257"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZLV2"/>
    <dbReference type="GeneID" id="9679158"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_59655"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_59655"/>
    <dbReference type="eggNOG" id="KOG3151">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046003_1_1_1"/>
    <dbReference type="InParanoid" id="C7ZLV2"/>
    <dbReference type="OMA" id="HIMDGYF"/>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.990:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006746">
        <property type="entry name" value="26S_Psome_Rpn12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="74"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU35000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="270" mass="30131" checksum="90653BD031FE99BF" modified="2009-10-13" version="1">MADRNLAQILAQLKHSPSMSYSDANALLSKAKLALLKLNALTPSPSTPAPLLPLARETYEQGALFAIRARNPDAFTRYVQQLQPFYELPASVLAPNLPERNKVTGLSLLLLLTQGRYAEFHTELESLANREGGGGDVESDRYLGYPIRLERWLMEGSYDRVWKAMKSSEVPCDEYSVFSEILKNQIRSEIASSSERAYPSLPISSTKSLLFLDSEGDVISFAHHRGWVVRDGQIYFPDAAEGEDGDQNKEMSQMVIENALGYARELETIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZM02</accession>
    <name>C7ZM02_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_11702</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698948">
        <property type="protein sequence ID" value="EEU34960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040673.1">
        <property type="nucleotide sequence ID" value="XM_003040627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZM02"/>
    <dbReference type="STRING" id="660122.C7ZM02"/>
    <dbReference type="GeneID" id="9679127"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_11702"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_11702"/>
    <dbReference type="eggNOG" id="ENOG502SK3B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009941_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZM02"/>
    <dbReference type="OMA" id="CEGALWQ"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF23">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU34960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="625" mass="69758" checksum="199C4884E7B684B0" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMA9</accession>
    <name>C7ZMA9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_55065</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698950">
        <property type="protein sequence ID" value="EEU34859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040572.1">
        <property type="nucleotide sequence ID" value="XM_003040526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMA9"/>
    <dbReference type="GeneID" id="9678995"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55065"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55065"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_6_1"/>
    <dbReference type="InParanoid" id="C7ZMA9"/>
    <dbReference type="OMA" id="DKMFYEF"/>
    <dbReference type="OrthoDB" id="268400at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF160">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU34859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="47400" checksum="6DC751C471C18709" modified="2009-10-13" version="1" fragment="single">AGVSPGLAQVVQEFHSDYTEASNIISYCLLAIGLGAWIWTPTAVVIGKRPVLVTSQLVFVASSIWGSQATSMQSLLGSRIVGGLGAELFYEKDYSKAMAAYTLSLCLGSQLGNLIGGHLIAARGWQWHFKLLAILGGINFVTLLFFCPETAYIQDIADNANAADVDDDIRRHTDGKKQNAMKSLTQNLFYLRHPHVRGGGLRQWVLSFLLQIEYTFNPTVLLSSGMWGISLAWVAGISVIQNPLFAAPPFNWSPAEIGNWAVTSTVGVVVAFPIAGPLTDFVSSQIGKRRGHHMPEHRLYTLILPFLVGSAGLIIFGYTYANGSYVGPAVGYAMQTSTLLLIPATVLSYGVDSYPYDSAEVVSLMNAVTHLIPFGLIKTASDWLERDGTRKMFLDMAIIQWALIAGITVVLILFGPFIRVQSHKIHAKYGAKRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMG0</accession>
    <name>C7ZMG0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_19227</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="GG698952">
        <property type="protein sequence ID" value="EEU34803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040516.1">
        <property type="nucleotide sequence ID" value="XM_003040470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMG0"/>
    <dbReference type="STRING" id="660122.C7ZMG0"/>
    <dbReference type="GeneID" id="9678940"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_19227"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_19227"/>
    <dbReference type="HOGENOM" id="CLU_138921_0_1_1"/>
    <dbReference type="InParanoid" id="C7ZMG0"/>
    <dbReference type="OMA" id="MNTVELT"/>
    <dbReference type="OrthoDB" id="5584477at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU34803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="104" mass="12325" checksum="5BCCE0748E8DAD29" modified="2009-10-13" version="1" fragment="single">KFNDILELLEAFRDAIKAYWSLYFDGGILYRDISTRNIIIPDIRKEGEQRGILIDLDLSKEVTDLSTTSEQIIRTRPFILIDLMKHGQHSYLHDLDSFFFVFLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMG9</accession>
    <name>C7ZMG9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_82373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698953">
        <property type="protein sequence ID" value="EEU34773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040486.1">
        <property type="nucleotide sequence ID" value="XM_003040440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMG9"/>
    <dbReference type="GeneID" id="9678905"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82373"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82373"/>
    <dbReference type="eggNOG" id="ENOG502RM68">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015493_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZMG9"/>
    <dbReference type="OMA" id="EWLWYVW"/>
    <dbReference type="OrthoDB" id="5130013at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF39">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU34773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="49417" checksum="1228F2DA1863F583" modified="2009-10-13" version="1">MVANPLGIPTNELGERPNTLFLINTTFNDMELYGHRTSRMYLDRLVTFSPILPNRPQVQAEHACLLQYFQDTAYRSLVTFGTTAEQIRDALMTMITAPDTSSSFALLHAILAYSSLHSQGPNKEAMALKIQALQFLSVSLNEGPMTTARAAQHVAASMLLGAFETLLPSDSSGEWLWHIWGAMDTIRAAQLENVSDESDTRHLLDWVYYHGVLSRFAVHHWRHQSLIQSRSNTRGGPSGDQYLQLSQYRPTLPSPNPTYAILSLLSEVCETLVDPRDPRSRHEDYIRRLKELESRIDTVPVTSTSAKLSHDATFAVELYQVATRIYLARASQSPWEPPANLDALIEAGFAGPSKTCTSGCEHFFPLLIIACEARREDQRVAILNLVERTQRDSRIRTVRGVMDAIQSIWVQQDLHADGDVLVNYLDVMSVGISSTSTIPSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMP1</accession>
    <name>C7ZMP1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase</fullName>
            <ecNumber evidence="3">1.1.1.302</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_87016</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27274"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27278"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HTP reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.302" evidence="3"/>
    <dbReference type="EMBL" id="GG698957">
        <property type="protein sequence ID" value="EEU34706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040419.1">
        <property type="nucleotide sequence ID" value="XM_003040373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMP1"/>
    <dbReference type="STRING" id="660122.C7ZMP1"/>
    <dbReference type="GeneID" id="9678842"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87016"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87016"/>
    <dbReference type="eggNOG" id="ENOG502SBB8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1058016_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZMP1"/>
    <dbReference type="OMA" id="TDWIVED"/>
    <dbReference type="OrthoDB" id="3192019at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050765">
        <property type="entry name" value="Riboflavin_Biosynth_HTPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011:SF11">
        <property type="entry name" value="2,5-DIAMINO-6-RIBOSYLAMINO-4(3H)-PYRIMIDINONE 5'-PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="Bacterial bifunctional deaminase-reductase C-terminal" evidence="10">
        <location>
            <begin position="2"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU34706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="263" mass="28766" checksum="E23768A7A0F43D25" modified="2009-10-13" version="1">MPQLRYNVATSLDGYIASPDGSADWIVDDPTIDFKALYEQFDFFVMGRKTYETMLSFGEPNENPLSNRPKKSVIVASQSLKPEDFPDITILSMNVLEFIRQLKLGTGKDIWLMGGSKLATQCMRAGLVDTVEAAVMPVVLGDGIKLMEAIDSTENLPVRLDLLGSERDHANNCGQRKAGSMPGLIGKLHQVDGVAEALIETHWLDPSDLAAGRADASKEMPVNTLPPIRAPFQMREHFPPHAGLTHVGLSDDSDDWVNGGQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMX4</accession>
    <name>C7ZMX4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_34844</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698959">
        <property type="protein sequence ID" value="EEU34658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040371.1">
        <property type="nucleotide sequence ID" value="XM_003040325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMX4"/>
    <dbReference type="STRING" id="660122.C7ZMX4"/>
    <dbReference type="GeneID" id="9678798"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_34844"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_34844"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1078033_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZMX4"/>
    <dbReference type="OMA" id="ESPICVC"/>
    <dbReference type="OrthoDB" id="4476201at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF6">
        <property type="entry name" value="GABA-SPECIFIC PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU34658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="28066" checksum="CD37CDC339845F3E" modified="2009-10-13" version="1">MADLPKKYLDPEAREDHHVDEQEDGTIEALGYGVSYRRVLKTIANVCWVLSLTSPAGAILVVSSYLVTYGGFFGLVWGWIIPSFLLLPQVLAVGELCSSMPVNGATYWWTAALAPPSMSRSLSFISGCTTVVSLFTAVASFAYACSSILVTCAFITGSGWMPNQAQQMGVAMGIVVIWVIGMSMQLDKVGNCSSSADAGVRDRPPRRTCSQRRLVCIRSQCLWLIYKLFELGSGCCCAYDMVRCRLDQLCLDSPSVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZN44</accession>
    <name>C7ZN44_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_88860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698962">
        <property type="protein sequence ID" value="EEU34570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040283.1">
        <property type="nucleotide sequence ID" value="XM_003040237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZN44"/>
    <dbReference type="GeneID" id="9678704"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88860"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88860"/>
    <dbReference type="HOGENOM" id="CLU_1768590_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZN44"/>
    <dbReference type="OrthoDB" id="5106889at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU34570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="147" mass="16695" checksum="4DF2D94FDFA05BE9" modified="2009-10-13" version="1">MYLPICNLNFGRQDKSVTKDYNRLVMPKFRERVRWIQRKMIEYGALVKTPNGWAREPGRRFANAEEAGLWLDNKLTLASTPTSSPAQPFQAQGIQNSMWSHSRSIPTVDDPLPEMGQLCLNDDSTSSSIFKDCVAPDYQARSRVDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNE5</accession>
    <name>C7ZNE5_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_44490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698967">
        <property type="protein sequence ID" value="EEU34445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040158.1">
        <property type="nucleotide sequence ID" value="XM_003040112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNE5"/>
    <dbReference type="GeneID" id="9677999"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_44490"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_44490"/>
    <dbReference type="eggNOG" id="ENOG502RMHB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140475_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZNE5"/>
    <dbReference type="OMA" id="CFPITLW"/>
    <dbReference type="OrthoDB" id="5102867at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU34445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="159" mass="16824" checksum="076C125A1F270092" modified="2009-10-13" version="1">MPFSMADLNKRDETASKIPAPAKGFGALFGGGGYAEVVCCPLSVIFWSGYAITKKIKKKRQEKKATAAEAEEEVAVGSSDRTNHKDAEKMAEGSRASHVSPTPSPGEVSGTAPLDPALQKHPNNPRVCDPECPGYGKDFCLAHQRKGTSRPTSPGLLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNS6</accession>
    <name>C7ZNS6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_50453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039958.1">
        <property type="nucleotide sequence ID" value="XM_003039912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNS6"/>
    <dbReference type="STRING" id="660122.C7ZNS6"/>
    <dbReference type="GeneID" id="9677687"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_50453"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_50453"/>
    <dbReference type="eggNOG" id="ENOG502SZ3Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067153_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZNS6"/>
    <dbReference type="OMA" id="VNSITIW"/>
    <dbReference type="OrthoDB" id="5337308at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="362" mass="40234" checksum="6CBA7FF14C80C216" modified="2009-10-13" version="1">MGTRPQSSWRSLLSFFSVALFSLLLLLYLGPSRNSGQDLRVPVTERDLHDDAVTNLTKRATATYQAASEKGAKLHCLLAMSKEDVEAADGGKYKEPAKWLQKWGIEDSQGWVTEAEEGEEGADKNAPYWGDYLDAAFSSLDISKSDAHNVHWIHLSDAEIFPDPEEFEGTAEQGVRSGAYFTNSYILDPGVIIADNNYAVVPALNDNFPGWEKIFTTTHIQRSQWSDAAWMQWTKTCDWFGGDRTKIKYIIRSRITNKTTLSLIFEALISKYGGFPTIGKWDDRLTLDVATNPGEFHAVLASPNGAGVAYILMNHKSTLGIKTVNKVEIFVPNIPYTVVGTSVDDPLVQRAKIMLLFTVISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPH8</accession>
    <name>C7ZPH8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ferrochelatase</fullName>
            <ecNumber evidence="12">4.98.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_63998</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>heme b + 2 H(+) = protoporphyrin IX + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.98.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ferrochelatase family.</text>
    </comment>
    <dbReference type="EC" id="4.98.1.1" evidence="12"/>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040063.1">
        <property type="nucleotide sequence ID" value="XM_003040017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZPH8"/>
    <dbReference type="FunCoup" id="C7ZPH8">
        <property type="interactions" value="771"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZPH8"/>
    <dbReference type="GeneID" id="9677795"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_63998"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_63998"/>
    <dbReference type="eggNOG" id="KOG1321">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018884_1_1_1"/>
    <dbReference type="InParanoid" id="C7ZPH8"/>
    <dbReference type="OMA" id="DPYHCEC"/>
    <dbReference type="OrthoDB" id="1323at2759"/>
    <dbReference type="UniPathway" id="UPA00252">
        <property type="reaction ID" value="UER00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1400:FF:000003">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1400">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108:SF1">
        <property type="entry name" value="FERROCHELATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 12" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU34350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="419" mass="46210" checksum="52A0F0003820CC44" modified="2009-10-13" version="1">MALRRSGGQLYKGISQASSHRLALPQIASQKRYLATPVPPVTQDATGSKGPTAMVFLNMGGPSTLDEVGDFLSRLFADGDLIPLGRLQNYLGPLISKRRTPKIQKQYDAIGGGSPIRKWSEYQSSEMCKILDKISPETAPHKPYVAFRYADPLTEEMYTQLLKDGFGNGRGGRAVAFTQYPQYSCSTTGSSLNELWKWRHRLEGKTNKESGDGSITWSVIDRWPVHSGLVEAFAQNIEAKLAEYPEDRRKDVVLLFSAHSLPMSVVNRGDPYPGEVAATVYAVMQRLKFSNPYRLCWQSQVGPSAWLGPQTADSVEEYIAKGQTDLVLIPIAFTSDHIETLYELDEEVIGESGHRDTVKRVESLNGSPVFIQALADIAKAHLAENQACSAQMGLRCPGCKSERCAESKRFFASQQAGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQ52</accession>
    <name>C7ZQ52_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_55951</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698983">
        <property type="protein sequence ID" value="EEU33847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039560.1">
        <property type="nucleotide sequence ID" value="XM_003039514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQ52"/>
    <dbReference type="GeneID" id="9667086"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55951"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55951"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="InParanoid" id="C7ZQ52"/>
    <dbReference type="OMA" id="NPNWIKD"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF52">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="250"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="463"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU33847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="489" mass="54123" checksum="F5E93B6D8A2E0BEF" modified="2009-10-13" version="1">MAANIKWHELPNNTNPVWYKDAGLRHNVALGLGLCLVIATNVSSVSHCCPQELHLIGMSVNEYLQPKTALANQIQDQVSILTGFQAMPSWQIFFKRPTGALLGIYVASFFIPSIVTPWIGDWISTKFGRRWCIIIANIIILIGALVNTFTVNIGMWCGVVGLYIPGNWGWRFPSLLQVIGPVAVILWLIMNDREDQARQILAALHANGDINDALVQFEVEQISTSIQKEALQQQASLADFLRTPGNRRRLVTIIAMACSLNWMGNGIIAYYLAPILQSVGITAPVQITLINVGLAIWNLILAAAAAVNCDKVGRRPLFLLSTAGMLCSYAVVMGLSAGFANTKTKALGIAVIPFLFIYYGFYDTAYTPLPIAYTVEILPFSIRSKGMALFTSTATLGNAFNQFVNPIALKSIQWRYYAVYIGILIFYFVFIFFMFPETKRLSAEDASKVFDFDRKGHPLGKAVDVERDAKKPGDEKEPVTSIVTHDDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQA0</accession>
    <name>C7ZQA0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_89117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698986">
        <property type="protein sequence ID" value="EEU33808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039521.1">
        <property type="nucleotide sequence ID" value="XM_003039475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQA0"/>
    <dbReference type="GeneID" id="9667043"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89117"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89117"/>
    <dbReference type="HOGENOM" id="CLU_1555682_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZQA0"/>
    <dbReference type="OrthoDB" id="5113664at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU33808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="172" mass="18986" checksum="5803857D7F1E8DDF" modified="2009-10-13" version="1">MQVMLRTTIGLQQGCIFGGSGVGHCLHRIMLLTDLSTQQPKSQVGGRIIDGVEGPQLGHASPTFRFLMWLCGLVRLPLNTDHPSPLAQIHQPPWENLRGCESSYRESNAYAKRSNADAKRSNADVKRPKAAPSRNNTNEKKNNADAKKSNADAKKSNADAKKPRNSQTHRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7YGT8</accession>
    <name>C7YGT8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Dipeptidyl peptidase 3</fullName>
            <ecNumber evidence="4 15">3.4.14.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 15">Dipeptidyl aminopeptidase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 15">Dipeptidyl peptidase III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">NECHADRAFT_30560</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.</text>
            <dbReference type="EC" id="3.4.14.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15 17">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M49 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.4" evidence="4 15"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053512.1">
        <property type="nucleotide sequence ID" value="XM_003053466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YGT8"/>
    <dbReference type="FunCoup" id="C7YGT8">
        <property type="interactions" value="652"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YGT8"/>
    <dbReference type="MEROPS" id="M49.004"/>
    <dbReference type="GeneID" id="9664311"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_30560"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_30560"/>
    <dbReference type="eggNOG" id="KOG3675">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011977_1_0_1"/>
    <dbReference type="InParanoid" id="C7YGT8"/>
    <dbReference type="OMA" id="QRYWIRD"/>
    <dbReference type="OrthoDB" id="4694525at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000001">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000002">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005317">
        <property type="entry name" value="Dipeptidyl-peptase3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039461">
        <property type="entry name" value="Peptidase_M49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422:SF11">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE III-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03571">
        <property type="entry name" value="Peptidase_M49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007828">
        <property type="entry name" value="Dipeptidyl-peptidase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15 17" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="16">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="506"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR007828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEU47799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="707" mass="78773" checksum="9D62F1B61F0E1667" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7YH26</accession>
    <name>C7YH26_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP-dependent RNA helicase DHX8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_74824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053556.1">
        <property type="nucleotide sequence ID" value="XM_003053510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YH26"/>
    <dbReference type="STRING" id="660122.C7YH26"/>
    <dbReference type="GeneID" id="9676888"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74824"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74824"/>
    <dbReference type="eggNOG" id="ENOG502RYIY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082565_1_0_1"/>
    <dbReference type="InParanoid" id="C7YH26"/>
    <dbReference type="OMA" id="RDRMTWI"/>
    <dbReference type="OrthoDB" id="413653at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025633">
        <property type="entry name" value="DUF4291"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38567">
        <property type="entry name" value="DUF4291 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38567:SF1">
        <property type="entry name" value="DUF4291 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14124">
        <property type="entry name" value="DUF4291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU47843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="24939" checksum="ED645716AA8FBEA8" modified="2009-10-13" version="1">MTSTSPDTSIPYHQIRAHYDGKTITVYQAYKESIARDAVAAQKLNASPDFKPGRMTWVKPSWAWMMYRAGYSYKDSRQSHILAIRMKHEHFIGLLERGVLSKHAKKAPEDSTVKREKTSDVRIQWDPERTPKLGVLPYRSIQIGIPGALSTQWADEWIFEIEDVTDKARELKRVIDERPDITEEELLELGLIFEERPFEVPESVGERLEITVPLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>C7YH32</accession>
    <name>C7YH32_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_57399</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053559.1">
        <property type="nucleotide sequence ID" value="XM_003053513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YH32"/>
    <dbReference type="STRING" id="660122.C7YH32"/>
    <dbReference type="GeneID" id="9664433"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_57399"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_57399"/>
    <dbReference type="eggNOG" id="ENOG502RSRA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019529_0_0_1"/>
    <dbReference type="InParanoid" id="C7YH32"/>
    <dbReference type="OMA" id="FPCFSET"/>
    <dbReference type="OrthoDB" id="5319458at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G12570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="607"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="535"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="617"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU47846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="661" mass="74924" checksum="BE8C7D1D4C9E66E0" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIK2</accession>
    <name>C7YIK2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_75353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053821.1">
        <property type="nucleotide sequence ID" value="XM_003053775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIK2"/>
    <dbReference type="GeneID" id="9664653"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75353"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75353"/>
    <dbReference type="eggNOG" id="ENOG502RXYE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029564_3_0_1"/>
    <dbReference type="InParanoid" id="C7YIK2"/>
    <dbReference type="OMA" id="FWTRREN"/>
    <dbReference type="OrthoDB" id="2448307at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040410">
        <property type="entry name" value="UPF0658_Golgi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391:SF1">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="364"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU48108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="432" mass="48476" checksum="5C980379A5C9EFA5" modified="2009-10-13" version="1">MHTVATRLESRRSLLGPEHGYGYGGHYNQPYSDGEPAPQPIPQPAAFTQPNFADTAGVDPAVNQGYAYREGFSPSVPATSTLNGKTGFLTSRWPACFMTVSLLQAVLCICFEAYIFGKFQFNLGPHINLPKVQSQYKTIPTFLTLFIFGFLYTLVVVWDALRQKNTIQVIGVCFSNLALMVYTAIQVDQIKEAFDILGAHNALEKNVTAADLWGDVKPYLVAIPAIIALATVGMIFISWKIYQEYAWDILKNIGADYRMKKRFLHYQIYIALLKFDFFFFLGFIVQFVVVVAEKNDPEFALTIVTIPITIAILLAAAYFTRKENKPGMVCVIILYLGGLSYFLFKLVRIYQPGHKEAYEAVRRSLTAFAVITILLILLTIANAIVCMCNFGKGLKPHLQSLSRKRKVEEKPDINSINMQDVKPQAPSRMTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIZ8</accession>
    <name>C7YIZ8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_99005</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053894.1">
        <property type="nucleotide sequence ID" value="XM_003053848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIZ8"/>
    <dbReference type="FunCoup" id="C7YIZ8">
        <property type="interactions" value="962"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YIZ8"/>
    <dbReference type="GeneID" id="9676529"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_99005"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_99005"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_1"/>
    <dbReference type="InParanoid" id="C7YIZ8"/>
    <dbReference type="OMA" id="GQLIMQY"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019413">
        <property type="term" value="P:acetate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07091">
        <property type="entry name" value="ALDH_F1-2_Ald2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000001">
        <property type="entry name" value="Mitochondrial aldehyde dehydrogenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="28"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU48181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="493" mass="53760" checksum="90AF1C508D93D9B0" modified="2009-10-13" version="1">MATLTVKLETPVTGPYDQPIGLFIDGEWVESVDKRKFEVINPSNEQVITSVYEGTEKDVDLAVAAARKAFENTWKGTTPGERAHLLYKLADLAEKNKELLAAVESLDNGKSINNARGDVDAVVGCLRYYGGWADKIEGKTIDIAPDMFHYTRSEPIGVCGQIIPWNFPLLMLSWKIGPALATGNTIVMKTAEQTPLSGLVFTELIKEAGFPRGVFNLVTGLGRVAGAAISSHMDIDKVAFTGSTLVGRQIMKAAADSNLKKVTLELGGKSPNIIFNDANIEEAVDWVNFGIYFNHGQICCAGSRVLVQEGVYDKFIEAFKKRAEENKVGDPFHEETFQGPLVSGLQYERVMSYINLGKEEGATVLTGGGRHGDKGYFIEPTIFTNVRPDMKIMREEIFGPVCAIAKFKDEEEALALAHDTPYGLAAAVHTQSLSTAIRFSNSLHAGTIWVNCYNLLHHAVPFGGYKESGIGRELGEAALANYTQSKSVAIRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJ68</accession>
    <name>C7YJ68_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_105858</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054643.1">
        <property type="nucleotide sequence ID" value="XM_003054597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJ68"/>
    <dbReference type="FunCoup" id="C7YJ68">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YJ68"/>
    <dbReference type="GeneID" id="9663711"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_105858"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_105858"/>
    <dbReference type="eggNOG" id="ENOG502SC55">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091398_1_0_1"/>
    <dbReference type="InParanoid" id="C7YJ68"/>
    <dbReference type="OMA" id="PWENPED"/>
    <dbReference type="OrthoDB" id="5551751at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040200">
        <property type="entry name" value="Mug57-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28156">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YDR262W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28156:SF1">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YDR262W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988349" description="FAS1 domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="45"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU48930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="193" mass="21229" checksum="467C7B7C16F63107" modified="2009-10-13" version="1">MKPLFALSTLLTLSTSSQVPLGDVKPDLHRLHLPVMPAAPLNQPSVALADILGTQRSLTSFSSFARMDPSTDERLADLGTNTTVLAPLNSAVDALPRKPWEQPGDYAALGADAYEGDKGQDRARENMRRFVEAHLVPESPWGENEKVKTVGGKEVWWVEKDGKRVVMPDEIEVDNVVGQVGNGELVSCMRRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJC3</accession>
    <name>C7YJC3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_73441</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS30 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054667.1">
        <property type="nucleotide sequence ID" value="XM_003054621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJC3"/>
    <dbReference type="FunCoup" id="C7YJC3">
        <property type="interactions" value="398"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YJC3"/>
    <dbReference type="GeneID" id="9676588"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_73441"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_73441"/>
    <dbReference type="eggNOG" id="KOG0009">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010412_5_1_1"/>
    <dbReference type="InParanoid" id="C7YJC3"/>
    <dbReference type="OMA" id="YNTQNVP"/>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006846">
        <property type="entry name" value="Ribosomal_eS30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S30/UBIQUITIN-LIKE PROTEIN FUBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650:SF15">
        <property type="entry name" value="RIBOSOMAL PROTEIN S30, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04758">
        <property type="entry name" value="Ribosomal_S30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU48954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="62" mass="6893" checksum="72A73396CB2A490D" modified="2009-10-13" version="1">MGKVHGSLARAGKVKSQTPKVEKQEKTKVPKGRALKRLKYTRRFVNVTMTGGKRKMNPNPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJD4</accession>
    <name>C7YJD4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7702 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_75639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054671.1">
        <property type="nucleotide sequence ID" value="XM_003054625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJD4"/>
    <dbReference type="STRING" id="660122.C7YJD4"/>
    <dbReference type="GeneID" id="9676592"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75639"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75639"/>
    <dbReference type="eggNOG" id="ENOG502T3R5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080476_0_0_1"/>
    <dbReference type="InParanoid" id="C7YJD4"/>
    <dbReference type="OMA" id="CWPIFLS"/>
    <dbReference type="OrthoDB" id="2560628at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056119">
        <property type="entry name" value="DUF7702"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G00100)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24800">
        <property type="entry name" value="DUF7702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="2">
        <location>
            <begin position="19"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU48958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="282" mass="30720" checksum="ABD4E94DD1B2B1A6" modified="2009-10-13" version="1">MSVTSTADLPPPPSADKINLAIADLVLYILLLFPVIRITWRHGKAGMVCWPIFISFFPLRFVSDAYQIAKRNEPSIPNAVAIMTNAGSIACLSLTIIGLIYEVNVILPLPPKRWTERIMLAVTHLAITAGIALATYGGAPKAGAKGGVVAENLNQTGNCLMMFTMIFGLGWWLWETKKRVMSLKSHPNFEPGKYLLLAACAALPFQLIRIGYNLTMAFTPYAVIDPFSGSFASRFLLMFGTQLCVAIAVTVGGWMSVGLVPAHALGQENQGFSRFTTPRAWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJU5</accession>
    <name>C7YJU5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pyrroline-5-carboxylate reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_75801</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU49038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054751.1">
        <property type="nucleotide sequence ID" value="XM_003054705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJU5"/>
    <dbReference type="STRING" id="660122.C7YJU5"/>
    <dbReference type="GeneID" id="9676672"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75801"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75801"/>
    <dbReference type="eggNOG" id="KOG3124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042344_1_0_1"/>
    <dbReference type="InParanoid" id="C7YJU5"/>
    <dbReference type="OMA" id="EDAMWIS"/>
    <dbReference type="OrthoDB" id="10263291at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF65">
        <property type="entry name" value="HYPOTHETICAL PYRROLINE-5-CARBOXYLATE REDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="4">
        <location>
            <begin position="180"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="6"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="75"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU49038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="31249" checksum="164BB90A9B5A6CCD" modified="2009-10-13" version="1">MRVALLGCGQMGSAIASALLQSRKTDTFRSLILSVNGQNSKSHLEKQFNEYRDRVQVLNLQNVQAAKDADTIILAHMPYMLKDILSETGMREAFKGKLVISILAGINARRIQDALGIPEGPDGAPPQREYELVRAMPNLAAQIKESMTLVKDPGPDASPESLQKATKLLEQFGKVLKVPEKTYHAAGMLTGAYYALITVALDGLMDGSMSEGMALSDVNTVAIQCLKGLTKLMEQGKKPEDIREFLSAPEGASYRGIATLERGNVRSAYAEAIVRATNRAKELEAQGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJY1</accession>
    <name>C7YJY1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">INGF2101</name>
        <name evidence="19" type="ORF">NECHADRAFT_105799</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in cell cycle progression and meiosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the ING family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054067.1">
        <property type="nucleotide sequence ID" value="XM_003054021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJY1"/>
    <dbReference type="SMR" id="C7YJY1"/>
    <dbReference type="FunCoup" id="C7YJY1">
        <property type="interactions" value="274"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YJY1"/>
    <dbReference type="GeneID" id="9676688"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_105799"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_105799"/>
    <dbReference type="eggNOG" id="KOG1973">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031900_7_0_1"/>
    <dbReference type="InParanoid" id="C7YJY1"/>
    <dbReference type="OMA" id="YEWFHWK"/>
    <dbReference type="OrthoDB" id="2505961at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16858">
        <property type="entry name" value="ING_ING3_Yng2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000695">
        <property type="entry name" value="Chromatin modification-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF100">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN YNG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 15 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="18">
        <location>
            <begin position="383"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="170"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="364"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEU48354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="437" mass="47013" checksum="0F8366B2CE16CAF2" modified="2009-10-13" version="1">MPRDDLSIDFVKRMPQAEPLDPGLILDDWINRVQNLPEEIRFIQEEIADKDRQYNECIRVIEDRDGKIQKWIKTNGSHEPNPKEELLRAQVRENYARADQLSQEKIALHQKMQLIMDKHLRSLDAQIKLLYDRAEPGFTDPDEVPSLLRPSAANHTAPSIRAINPASHMAATGPATPLTAAQTSSNPTLARLPNHPNVRHAQAQQHAASAPATPAASMILNRQREGSAGPATKRGPRINPSLGSIPVTSSGLARHSSLGPGTPKGGVAGGPAALARAGSAGPRASSVKSMGTASARRGTPTAGGRKKIANKSSLSRVKKASSRNSPAPTVDSELSDVDSGSGDDEDGADGRSRGTPVIDGKDGDGDEVLGDADDDDEEGGDDKKYCLCHNVSYGDMVACDNDNCPYEWFHWSCVGLKSEPNGTWYCPVCTEKFKKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C7YK51</accession>
    <name>C7YK51_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-hexosaminidase</fullName>
            <ecNumber evidence="7">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_89921</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="7"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054100.1">
        <property type="nucleotide sequence ID" value="XM_003054054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YK51"/>
    <dbReference type="STRING" id="660122.C7YK51"/>
    <dbReference type="GeneID" id="9664031"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89921"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89921"/>
    <dbReference type="eggNOG" id="KOG2499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007082_0_2_1"/>
    <dbReference type="InParanoid" id="C7YK51"/>
    <dbReference type="OMA" id="GHDVVMC"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06562">
        <property type="entry name" value="GH20_HexA_HexB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000063">
        <property type="entry name" value="Beta-hexosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF58">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988440" description="Beta-hexosaminidase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="11">
        <location>
            <begin position="20"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="10">
        <location>
            <begin position="212"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001093-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU48387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="591" mass="66617" checksum="35968977F199327C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLH8</accession>
    <name>C7YLH8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_77536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052978.1">
        <property type="nucleotide sequence ID" value="XM_003052932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YLH8"/>
    <dbReference type="GeneID" id="9663744"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77536"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77536"/>
    <dbReference type="eggNOG" id="ENOG502SNSN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_402887_0_0_1"/>
    <dbReference type="InParanoid" id="C7YLH8"/>
    <dbReference type="OMA" id="ACTNSET"/>
    <dbReference type="OrthoDB" id="3549294at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU47265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="651" mass="73498" checksum="01E659A9388B2F12" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLI4</accession>
    <name>C7YLI4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_77545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052502.1">
        <property type="nucleotide sequence ID" value="XM_003052456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YLI4"/>
    <dbReference type="STRING" id="660122.C7YLI4"/>
    <dbReference type="GeneID" id="9671034"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77545"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77545"/>
    <dbReference type="eggNOG" id="ENOG502T639">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023361_0_0_1"/>
    <dbReference type="InParanoid" id="C7YLI4"/>
    <dbReference type="OMA" id="WQLEHIF"/>
    <dbReference type="OrthoDB" id="5055179at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988469" description="F-box domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU46789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="56551" checksum="025DFABB5CFAA32A" modified="2009-10-13" version="1">MSLHSTASAPYLLLLSLSHSTIDAETTKSVKKKTRRLSKMKKLPPEIICQILNDLTPSSLKAIRICWRFLEPFILPRLFHTIKINFAEKQIKRLQGIALSPNLAPLVQQLIWTTSGTRDTHDDPHGHVNTWAGHEDYIKETWPQDLDPERDEIDGLVYALWPAMCRSQSRITSFRCQDPLNYMRWLNYECLQAMGGLHTELPASFPASPLRATVGLLFRKELSLSNPIPRRDFVIRLIMAQLPMIGPHPASTVAWKRPLRSLGGLDLRIDSAGGHWRGPPSSEGMLKYFLTEASNIRELSLRFRPTGTYPRPTSHSKWVLQAVLCCGWEFLQTIKISFAMLPTSQPLFKFMEGHAKTLKHILLHQCSANEDIIEIIRGAAKVKDIKLHRFLVFPSCEGRLEVDEPRIIPERLVLDFINNKDPSLDPFDEWMPGKSCNWGTIAQKAASVSEEWPKDDGMHFTCRQCTDQVQEAASKQRFVDGECYDGESGVYRSLNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLN0</accession>
    <name>C7YLN0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6590 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_77591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052521.1">
        <property type="nucleotide sequence ID" value="XM_003052475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YLN0"/>
    <dbReference type="GeneID" id="9671053"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77591"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77591"/>
    <dbReference type="eggNOG" id="ENOG502T1JE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_647398_0_0_1"/>
    <dbReference type="InParanoid" id="C7YLN0"/>
    <dbReference type="OrthoDB" id="3438983at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046497">
        <property type="entry name" value="DUF6590"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20233">
        <property type="entry name" value="DUF6590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6590" evidence="2">
        <location>
            <begin position="241"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU46808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="424" mass="49088" checksum="A82CDF0555511B15" modified="2009-10-13" version="1">MPTHAYYGSCRVSKRPPTWRSRNERRNGTDSWTPDKDSRSERGDSKDGRDRQDNHRDRTGEREDSRNGRNRRDRRGEREDTRDEREDSVHNNYGRVNNNYNINIRSFGDNDRSRHWNGNVLRDRNFNTYVRNRPRRDRFDNRRYSPALSSRQSSRRTSFSSRTRSWVTSDSNTNSFSDRPVDSIETPRGGEDTDETGRRERDDGDDEYYGARQAYRDISRGDVVQGRMRPTDRVCDESELRLGAIISTAIHNQAREDTVAIDEFNKSLSGFGIVYSKYRKLIVVEEWAQHVVCIPLYTYNGRGLAGREALACEYFDVRDVGDPDPESGDTFCTLMAVRDREWPMENTFIEGRTVAKVTEKITFYRTNKCSIEGRIDQESLSTLIPPYLRSSTNPLAKFLSRSQSNSPADSPTDDAASEKEEGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7YN13</accession>
    <name>C7YN13_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="1">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_78070</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="1"/>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052760.1">
        <property type="nucleotide sequence ID" value="XM_003052714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YN13"/>
    <dbReference type="STRING" id="660122.C7YN13"/>
    <dbReference type="GeneID" id="9664244"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78070"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78070"/>
    <dbReference type="eggNOG" id="ENOG502SC9F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_5_0_1"/>
    <dbReference type="InParanoid" id="C7YN13"/>
    <dbReference type="OMA" id="TWYRGGW"/>
    <dbReference type="OrthoDB" id="338622at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02970">
        <property type="entry name" value="PRX_like2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050924">
        <property type="entry name" value="Peroxiredoxin_BCP/PrxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801:SF7">
        <property type="entry name" value="SLL1159 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="41"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU47047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="213" mass="23752" checksum="F5DD9D236FAC33DB" modified="2009-10-13" version="1">MSSQSEQLTAIAQSFKGVPGSEPITTAIEDFVQFFKPQNAVQVGDKFPSFRLSDATGKEVSSDDLLANGPLLITFYRGEWCPYCNIALQHLQRHLDEYKARGVTLVALTPELPDYSLTTAEKNEIKFPVLTDRNNEVAKKLGIVFDQSSAKDLFKQVGVDLSKRNGLDNFEVPIPATLLVDGSGIVRNVYIDPDYRNRMEPKVALEWIDALKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7YN36</accession>
    <name>C7YN36_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TRP C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_99744</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053265.1">
        <property type="nucleotide sequence ID" value="XM_003053219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YN36"/>
    <dbReference type="GeneID" id="9671303"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_99744"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_99744"/>
    <dbReference type="eggNOG" id="ENOG502RS5S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014990_0_0_1"/>
    <dbReference type="InParanoid" id="C7YN36"/>
    <dbReference type="OMA" id="EWYNLVH"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF8">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_2G17475)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002986337" description="TRP C-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="722"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="662"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU47552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="747" mass="82798" checksum="922AA2381A0D22FB" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7YN72</accession>
    <name>C7YN72_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_78128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053287.1">
        <property type="nucleotide sequence ID" value="XM_003053241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YN72"/>
    <dbReference type="GeneID" id="9664353"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78128"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78128"/>
    <dbReference type="eggNOG" id="ENOG502T38D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1023399_0_0_1"/>
    <dbReference type="InParanoid" id="C7YN72"/>
    <dbReference type="OMA" id="RTITTMY"/>
    <dbReference type="OrthoDB" id="4973016at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU47574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="272" mass="30499" checksum="E129F0A63490F9D7" modified="2009-10-13" version="1">MDALQTAKKEWGKGHEEGPYTSMRMVKYLIDQSGLSLQGFVSHPHQTLKEWTFPQTLKHVQAQRRKNSPELELTWNSKTGRCTALAHKVSGRLEEKGPDTFCFEHFNMTSGRAGHRLSRCRKTGVVIDSSSTVGAAMVPELTDWILVGNVKCKFDGSQSWTEITRSGASNLALEDEGKQIQKKSPPITHEEAQAHCLSEVAQQVPLLTYFRSFQNGQPKLHGMMKFQLDTKGNWRQLDLIPDPEVKDGQKHTGCIVWNQGGTEATKGVPSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNT2</accession>
    <name>C7YNT2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_38178</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051884.1">
        <property type="nucleotide sequence ID" value="XM_003051838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNT2"/>
    <dbReference type="STRING" id="660122.C7YNT2"/>
    <dbReference type="GeneID" id="9670865"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_38178"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_38178"/>
    <dbReference type="eggNOG" id="KOG2474">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023518_1_0_1"/>
    <dbReference type="InParanoid" id="C7YNT2"/>
    <dbReference type="OMA" id="HVVDCAH"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF210">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="101"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="264"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU46171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="505" mass="55648" checksum="81639DDECA463D99" modified="2009-10-13" version="1">MATTVVADSIDNDTRGWIMCVVSGIACVLGASIMFSALYSMLPESKEYFEQAKWSKQAAGLTMMACFITGFIGIQAISRLLHQFMPTHVVDCDHTHDKAANKDNEACQHSRRQSRASRARHRISRPSSSHVPVDKSLTRVANGHDHDAPVESTPLLESARNGQARVPKRHASARGDEMQQRPFSPTSANQPRPLSSSTEALSERRKSIREVQKRVMSFVQDTKCNCDELNSCYGYTDPCGQECFKHLGNRSGLPPRQPHILRTTTGSFLGRGHDHPHDHHDHHHHSHVEDIDESEPLSPSFRTSRAKSREPIDPNAPTEVSDHDSSCSSMEQDDDVEAQHHHHVPTNAFLSIGLQTSIAIALHKFPEGFITYATNHVNPALGFNVFMALFVHNITEGFAMCLPLYMALGSRWRAMAWSAFLGGLSQPIGAGIAALWFKLASRTNMTPNSVAYACLFAATSGIMVSVALQLFVESLSLNHNRNLCILFGFLGMVLLGLSNALIGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7YP04</accession>
    <name>C7YP04_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_79487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EEU46667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052380.1">
        <property type="nucleotide sequence ID" value="XM_003052334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YP04"/>
    <dbReference type="GeneID" id="9672998"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79487"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79487"/>
    <dbReference type="eggNOG" id="ENOG502RNJW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_280761_0_0_1"/>
    <dbReference type="InParanoid" id="C7YP04"/>
    <dbReference type="OrthoDB" id="5089448at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU46667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1118" mass="125018" checksum="51236A75D4DAF500" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7YP11</accession>
    <name>C7YP11_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">HTA2101</name>
        <name evidence="16" type="ORF">NECHADRAFT_59698</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4 12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051923.1">
        <property type="nucleotide sequence ID" value="XM_003051877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YP11"/>
    <dbReference type="FunCoup" id="C7YP11">
        <property type="interactions" value="1002"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YP11"/>
    <dbReference type="GeneID" id="9672851"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_59698"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_59698"/>
    <dbReference type="eggNOG" id="KOG1756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062828_3_0_1"/>
    <dbReference type="InParanoid" id="C7YP11"/>
    <dbReference type="OMA" id="CALESQH"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000008">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="13"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="15">
        <location>
            <begin position="94"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEU46210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="134" mass="14152" checksum="F996259DEC4850F8" modified="2009-10-13" version="1">MTGGGKSGGKASGSKNAQSRSSKAGLAFPVGRVHRLLRKGNYAQRVGAGAPVYLAAVLEYLAAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGHVTIAQGGVLPNIHQNLLPKKTVKGGKNASQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7YP55</accession>
    <name>C7YP55_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_68001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. MAK3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051952.1">
        <property type="nucleotide sequence ID" value="XM_003051906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YP55"/>
    <dbReference type="FunCoup" id="C7YP55">
        <property type="interactions" value="460"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YP55"/>
    <dbReference type="GeneID" id="9672850"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_68001"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_68001"/>
    <dbReference type="eggNOG" id="KOG3139">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_0_3_1"/>
    <dbReference type="InParanoid" id="C7YP55"/>
    <dbReference type="OMA" id="LCIFARH"/>
    <dbReference type="OrthoDB" id="249099at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044542">
        <property type="entry name" value="NAA30-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="13"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU46239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="188" mass="21491" checksum="EAE4A268376DF2C2" modified="2009-10-13" version="1">MDLTQIDNLPGELRYVQYEHALEAQYLPAIRALISKDLSEPYSIYVYRYFLCQWAHLCFMALNPVDSSLIGVIICKLEIHASHSNPTRRGYIAMLAVASDFRGHGIATTLVKKAIDAMTKRNADEIVLETEETNVPAMRLYEQLGFLRSKKLHRYYLNGNSAYRLVLPLKYIDPDANPNDLDILDMHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPT2</accession>
    <name>C7YPT2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_92587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051619.1">
        <property type="nucleotide sequence ID" value="XM_003051573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YPT2"/>
    <dbReference type="STRING" id="660122.C7YPT2"/>
    <dbReference type="GeneID" id="9673287"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_92587"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_92587"/>
    <dbReference type="eggNOG" id="ENOG502RY7V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014569_0_0_1"/>
    <dbReference type="InParanoid" id="C7YPT2"/>
    <dbReference type="OMA" id="CSCRIAE"/>
    <dbReference type="OrthoDB" id="4495335at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42041">
        <property type="entry name" value="DNA ENDONUCLEASE ACTIVATOR CTP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42041:SF1">
        <property type="entry name" value="DNA ENDONUCLEASE ACTIVATOR CTP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="552"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="420"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="552"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="569"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU45906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="641" mass="72399" checksum="11C16E762405A96B" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPX7</accession>
    <name>C7YPX7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL49</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_78909</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL49 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052083.1">
        <property type="nucleotide sequence ID" value="XM_003052037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YPX7"/>
    <dbReference type="STRING" id="660122.C7YPX7"/>
    <dbReference type="GeneID" id="9668793"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78909"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78909"/>
    <dbReference type="eggNOG" id="KOG4034">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121541_0_0_1"/>
    <dbReference type="InParanoid" id="C7YPX7"/>
    <dbReference type="OMA" id="YRRWQSG"/>
    <dbReference type="OrthoDB" id="19439at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007740">
        <property type="entry name" value="Ribosomal_mL49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477">
        <property type="entry name" value="MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05046">
        <property type="entry name" value="Img2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU46370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="168" mass="19196" checksum="DF79C6AA495C354B" modified="2009-10-13" version="1">MRLLAPRTLSAGCQALLQRPVPLVQRCTYASASQPTFKTHAGYRTNPLDKPVNPNKKNKIPYKDRPMKRFFAPLPTKTEEQLAAAFPYIVRRTPYSQLPVYQKWMSGGNRVIVLIKKVDGDRTRLVEDLATALEVKRSDIRLNPTTQHIEIKGQYFKPAMDWLLNAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQ68</accession>
    <name>C7YQ68_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit OST2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_78998</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DAD/OST2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051679.1">
        <property type="nucleotide sequence ID" value="XM_003051633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQ68"/>
    <dbReference type="FunCoup" id="C7YQ68">
        <property type="interactions" value="732"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YQ68"/>
    <dbReference type="GeneID" id="9673438"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78998"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78998"/>
    <dbReference type="eggNOG" id="KOG1746">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111220_0_0_1"/>
    <dbReference type="InParanoid" id="C7YQ68"/>
    <dbReference type="OMA" id="HIILHIV"/>
    <dbReference type="OrthoDB" id="445566at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003038">
        <property type="entry name" value="DAD/Ost2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02109">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005588">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU45966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="143" mass="15540" checksum="13861F62895FF848" modified="2009-10-13" version="1">MAPKKNVRDITPTAAAVQASAAAPAAASQPKAKKSGDSWDKVLQNIYDHYIQDTPQRTKLIDVFLVPGASCETHQILTSTQPFNAFLSGFSATVGQFVLTASLRVQTSQSNKTEFPSVSPERAFADYVVCSLILHFFCVNFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQ82</accession>
    <name>C7YQ82_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM7</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MCM7</name>
        <name evidence="15" type="ORF">NECHADRAFT_92685</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051689.1">
        <property type="nucleotide sequence ID" value="XM_003051643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQ82"/>
    <dbReference type="FunCoup" id="C7YQ82">
        <property type="interactions" value="985"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YQ82"/>
    <dbReference type="GeneID" id="9673442"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_92685"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_92685"/>
    <dbReference type="eggNOG" id="KOG0482">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000995_7_2_1"/>
    <dbReference type="InParanoid" id="C7YQ82"/>
    <dbReference type="OMA" id="AQHVTYV"/>
    <dbReference type="OrthoDB" id="3207464at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033679">
        <property type="term" value="F:3'-5' DNA/RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904931">
        <property type="term" value="F:MCM complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006267">
        <property type="term" value="P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17758">
        <property type="entry name" value="MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000004">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000288">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24901">
        <property type="entry name" value="WHD_MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01663">
        <property type="entry name" value="MCMPROTEIN7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="393"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU45976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="813" mass="90942" checksum="D1B32EE640F34470" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQJ9</accession>
    <name>C7YQJ9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LAA1-like C-terminal TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_68461</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEATR5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052194.1">
        <property type="nucleotide sequence ID" value="XM_003052148.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="C7YQJ9">
        <property type="interactions" value="109"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YQJ9"/>
    <dbReference type="GeneID" id="9672664"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_68461"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_68461"/>
    <dbReference type="eggNOG" id="KOG1822">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000503_0_0_1"/>
    <dbReference type="InParanoid" id="C7YQJ9"/>
    <dbReference type="OMA" id="YPQVIQE"/>
    <dbReference type="OrthoDB" id="192608at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001484">
        <property type="entry name" value="HEAT repeat containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040108">
        <property type="entry name" value="Laa1/Sip1/HEATR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046837">
        <property type="entry name" value="Laa1/Sip1/HEATR5-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057981">
        <property type="entry name" value="TPR_LAA1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663">
        <property type="entry name" value="HYPOTHETICAL HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20210">
        <property type="entry name" value="Laa1_Sip1_HTR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25808">
        <property type="entry name" value="TPR_LAA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LAA1-like C-terminal TPR repeats" evidence="3">
        <location>
            <begin position="1879"/>
            <end position="2036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU46481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="2056" mass="222928" checksum="FA17708EFC6A6BC4" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRB1</accession>
    <name>C7YRB1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Integral membrane bound transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_93538</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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            <end position="435"/>
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        <source>
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        <source>
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    </evidence>
    <sequence length="1045" mass="116215" checksum="82777120FB59E634" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSX1</accession>
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        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rodriguez-Carres M."/>
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                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
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                <person name="Molnar I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
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                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
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                <person name="Salamov A."/>
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                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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            <end position="18"/>
        </location>
    </feature>
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            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="151"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU45765.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="185" mass="19868" checksum="82F851550C90FAD6" modified="2009-10-13" version="1">MKVFTLLVPLLSAPLAFAAPGDYGYGYGNTKTVTATVTVTKNYPQPPVTKTKTLTVTQPAVTKTETVYKHKPPVTKTITVTQPPVTVTKPPVTVTKPPVTITKPPVTKTETVYKHKTVTVTQPAITKTKTITVTKTVTEYPRKTHDKPGYGNPGYGNPGYGNGGGKDKDKDGGKKLTDSLRHESC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>C7YTB4</accession>
    <name>C7YTB4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_80246</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050718.1">
        <property type="nucleotide sequence ID" value="XM_003050672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YTB4"/>
    <dbReference type="STRING" id="660122.C7YTB4"/>
    <dbReference type="GeneID" id="9668494"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_80246"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_80246"/>
    <dbReference type="eggNOG" id="KOG2294">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002508_1_0_1"/>
    <dbReference type="InParanoid" id="C7YTB4"/>
    <dbReference type="OMA" id="HYKSDKV"/>
    <dbReference type="OrthoDB" id="5402974at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060962">
        <property type="term" value="P:regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045178">
        <property type="entry name" value="Fhl1/FHA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21712">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN FHL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21712:SF29">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN FHL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="5">
        <location>
            <begin position="453"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Fork-head" evidence="6">
        <location>
            <begin position="781"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="3">
        <location>
            <begin position="781"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="175"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="337"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="566"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="916"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1137"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="56"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="590"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="625"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="679"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="709"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="719"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="738"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="916"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="935"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="945"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="957"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="977"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="993"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1011"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1039"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1146"/>
            <end position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU45005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1246" mass="132153" checksum="F45732ADD77C3D03" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7YTK4</accession>
    <name>C7YTK4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine/threonine-protein kinase BUR1</fullName>
            <ecNumber evidence="4">2.7.11.22</ecNumber>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Serine/threonine-protein kinase bur1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">NECHADRAFT_63411</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="4"/>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049972.1">
        <property type="nucleotide sequence ID" value="XM_003049926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YTK4"/>
    <dbReference type="FunCoup" id="C7YTK4">
        <property type="interactions" value="208"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YTK4"/>
    <dbReference type="GeneID" id="9675136"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_63411"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_63411"/>
    <dbReference type="eggNOG" id="KOG0600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_21_1"/>
    <dbReference type="InParanoid" id="C7YTK4"/>
    <dbReference type="OMA" id="ENMPGWK"/>
    <dbReference type="OrthoDB" id="28397at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070691">
        <property type="term" value="C:P-TEFb complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070693">
        <property type="term" value="C:P-TEFb-cap methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07866">
        <property type="entry name" value="STKc_BUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000562">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000514">
        <property type="entry name" value="Serine/threonine-protein kinase BUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF233">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 16 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="37"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="370"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="404"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EEU44259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="486" mass="55977" checksum="70161A6E92AD3F49" modified="2009-10-13" version="1">MDKVPDSTPNGTSPRTFALNHSRPRSSFKGCSRISDYELQGKLGEGTFGEVHRARSRKTGALVALKKIIMHHEKDGFPITALREIKLLKLLSHKNILKLEDMAIEHPTRQTDKRKKPIVYMATPYMDHDLSGLLDNPSVHFKEPQIKCYMLQLLEGLRYLHDNNILHRDMKAANLLISNQGILQIADFGLARHYDGPVPEAGRPMGEGRRDYTGLVVTRWYRPPELLLQLRQYTPAIDVWGVGCVFGEMLVGKPILAGDSDAHQLEMIWDLMGSPTEETMPRWKSLPGGEHLSPRPRTGNLQNRFRDFGSGPVSLLRELLKLDWRTRINAVDALQHPYFKMQPLPLEPHEIPTYEESHELDRRKFHDRKAALPPAPKGGTVGLGPDANGATAGFNSNEPYGNGRNDDPGRRRDDRPPRDDRPPRDDRPPRDDRLPRDDRPRDERRRRDSRDDRRYDRDRGTMSRSRSPRHDRSRDRERSDRDVYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7YTU7</accession>
    <name>C7YTU7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_101582</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050021.1">
        <property type="nucleotide sequence ID" value="XM_003049975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YTU7"/>
    <dbReference type="FunCoup" id="C7YTU7">
        <property type="interactions" value="414"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YTU7"/>
    <dbReference type="GeneID" id="9675180"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101582"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101582"/>
    <dbReference type="eggNOG" id="KOG2355">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057592_3_0_1"/>
    <dbReference type="InParanoid" id="C7YTU7"/>
    <dbReference type="OMA" id="YLGTEWV"/>
    <dbReference type="OrthoDB" id="6512918at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00267">
        <property type="entry name" value="ABC_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001332">
        <property type="entry name" value="Similar to ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43158">
        <property type="entry name" value="SKFA PEPTIDE EXPORT ATP-BINDING PROTEIN SKFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43158:SF2">
        <property type="entry name" value="SKFA PEPTIDE EXPORT ATP-BINDING PROTEIN SKFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="10"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="252"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU44308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="287" mass="32011" checksum="DF15FB913FE66165" modified="2009-10-13" version="1">MTVPPKPPRIQVNDLSYTFPDYSTGIKNITLDLPPRSRTLLIGANGAGKTTLLRLLAGKRLSPSNTISICGVDPFKESLEGVTYLGLEWVLNPIVRNDIGVNELLRSVGGDAYPERRDELVAMLDVDTNWRMHAVSDGERRRVQLAMGLVRPWTILLLDEITVDLDVLSRAEFLGWLKRETEIRECTIVYATHILDNLAGWPSHLVHMHLGTVKEWDEADKMLSTIDGTVGASGNSRLGELVLGWLRDDRKERGPRSHMKRAPEGKTYGFGGIQIGGYGDESKQREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7YTW0</accession>
    <name>C7YTW0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_1518</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050025.1">
        <property type="nucleotide sequence ID" value="XM_003049979.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YTW0"/>
    <dbReference type="STRING" id="660122.C7YTW0"/>
    <dbReference type="GeneID" id="9675189"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_1518"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_1518"/>
    <dbReference type="eggNOG" id="ENOG502SM93">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011409_2_0_1"/>
    <dbReference type="InParanoid" id="C7YTW0"/>
    <dbReference type="OMA" id="QECHFEP"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="300"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU44312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="620" mass="69686" checksum="E2FCF2B2329DB690" modified="2009-10-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7YTZ3</accession>
    <name>C7YTZ3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C-8 sterol isomerase</fullName>
            <ecNumber evidence="8">5.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Delta-8--delta-7 sterol isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_71809</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ERG2 family.</text>
    </comment>
    <dbReference type="EC" id="5.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050423.1">
        <property type="nucleotide sequence ID" value="XM_003050377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YTZ3"/>
    <dbReference type="FunCoup" id="C7YTZ3">
        <property type="interactions" value="164"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YTZ3"/>
    <dbReference type="GeneID" id="9665396"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_71809"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_71809"/>
    <dbReference type="eggNOG" id="KOG4143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085469_0_0_1"/>
    <dbReference type="InParanoid" id="C7YTZ3"/>
    <dbReference type="OMA" id="AMYVIHA"/>
    <dbReference type="OrthoDB" id="347124at2759"/>
    <dbReference type="UniPathway" id="UPA00768"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006716">
        <property type="entry name" value="ERG2_sigma1_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868">
        <property type="entry name" value="SIGMA 1-TYPE OPIOID RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868:SF1">
        <property type="entry name" value="SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04622">
        <property type="entry name" value="ERG2_Sigma1R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU44710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="224" mass="25070" checksum="6DA31CB65C37254A" modified="2009-10-13" version="1">MPKTQPQSGISRLLGILGLLTALLASVFYVLEQNLDKFYIFDLEHLDDLSKRALAEHGSNTRAVVEYIVTELNEKTPAHINLNEEWVFNNAGGAMGAMYIIHASVTEYLIVFGTAIGTEGHTGRHTADDYFHILSGTQLAYVPGSYEPEVYPPGSIHHLRRGDVKQYKMPESCFALEYARGWIPPMLFFGFADGLSSTLDFPTLWHTTRITGREMISNLLKGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7YU69</accession>
    <name>C7YU69_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_84820</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS54 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050076.1">
        <property type="nucleotide sequence ID" value="XM_003050030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YU69"/>
    <dbReference type="FunCoup" id="C7YU69">
        <property type="interactions" value="453"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YU69"/>
    <dbReference type="GeneID" id="9665435"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84820"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84820"/>
    <dbReference type="eggNOG" id="KOG2115">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003094_1_0_1"/>
    <dbReference type="InParanoid" id="C7YU69"/>
    <dbReference type="OMA" id="QKQAVML"/>
    <dbReference type="OrthoDB" id="10259024at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048359">
        <property type="entry name" value="EXOC6_Sec15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039745">
        <property type="entry name" value="Vps54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012501">
        <property type="entry name" value="Vps54_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20651">
        <property type="entry name" value="EXOC6_Sec15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07928">
        <property type="entry name" value="Vps54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC6/Sec15 N-terminal" evidence="10">
        <location>
            <begin position="194"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 C-terminal" evidence="9">
        <location>
            <begin position="728"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="55"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="445"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="523"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="973"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="219"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="532"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="976"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU44363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1013" mass="112109" checksum="BDD4E56B2A1AE588" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVG4</accession>
    <name>C7YVG4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_85267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050686.1">
        <property type="nucleotide sequence ID" value="XM_003050640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVG4"/>
    <dbReference type="GeneID" id="9675082"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85267"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85267"/>
    <dbReference type="eggNOG" id="ENOG502S69E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038300_0_0_1"/>
    <dbReference type="InParanoid" id="C7YVG4"/>
    <dbReference type="OMA" id="SHQCEIL"/>
    <dbReference type="OrthoDB" id="5063527at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU44973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="479" mass="52314" checksum="EE925EB3E7921D60" modified="2009-10-13" version="1">MGACSNCRRRKKKCDEGLPETSALGAGDCFTRTFCAAFPGDNGSTAGRKSASDTVVTSVAGSTDGLRATIGPSGFDQVSATLSGPGIFASGLEVASESTGSPPVNDALSRAQETFTRFLTSGLTRLHKTGTSCTVPDMMQTLATRSHALLFIGVAIQQAFDDKGEEFSVSTLEHLDVALSTLRAEIIQGQGTPHAGTLTAGVLLCTFHGWPCTHHLRLISEGYRFQTTMNTVATGLEQDPSSRQALESLGVMDLPSFVLGRNSPTIGIWKSFRIAQGSWNQGRLDGVEPVTGIPRSLLDIFAAVAEEPGDDIALRFWSWQDGGGDTTQCRLWDCWRLSGILDVRRRRRRLFSNVDFTPLAQSDDEPRDSAPDTDTILCRLMAAIDSVHKALSIPCPENLPSYHGLVYPLVTISLEVARLRRHPEWKQTLDEVRYRIEENSPFRLARIAFKLLDDSWREESSDFDIEDAAREMGVEIALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7YW94</accession>
    <name>C7YW94_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">NECHADRAFT_65195</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 14"/>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU43923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049636.1">
        <property type="nucleotide sequence ID" value="XM_003049590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YW94"/>
    <dbReference type="FunCoup" id="C7YW94">
        <property type="interactions" value="957"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YW94"/>
    <dbReference type="GeneID" id="9677426"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_65195"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_65195"/>
    <dbReference type="eggNOG" id="KOG3359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008438_5_0_1"/>
    <dbReference type="InParanoid" id="C7YW94"/>
    <dbReference type="OMA" id="MCGWDDN"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23284">
        <property type="entry name" value="beta-trefoil_MIR_PMT2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000012">
        <property type="entry name" value="Protein O-mannosyl-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="58"/>
            <end position="75"/>
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    </feature>
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            <begin position="144"/>
            <end position="163"/>
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    </feature>
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            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
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            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
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            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
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            <end position="621"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
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            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="668"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="699"/>
            <end position="721"/>
        </location>
    </feature>
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        <location>
            <begin position="334"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="400"/>
            <end position="456"/>
        </location>
    </feature>
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        <location>
            <begin position="464"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
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            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEU43923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="740" mass="84528" checksum="D40084159D455014" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWF2</accession>
    <name>C7YWF2_FUSV7</name>
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        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="10" type="ORF">NECHADRAFT_89785</name>
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        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89785"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
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        <property type="entry name" value="APC_YAT"/>
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        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF6">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="87"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="251"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="482"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="41"/>
            <end position="509"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU43949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="555" mass="60758" checksum="7FA61B66FB6DFC88" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWM6</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_30113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698901">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="9677273"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_30113"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_30113"/>
    <dbReference type="eggNOG" id="ENOG502S1SC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027663_0_0_1"/>
    <dbReference type="InParanoid" id="C7YWM6"/>
    <dbReference type="OMA" id="KYIPTPF"/>
    <dbReference type="OrthoDB" id="5376312at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU43985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="397" mass="43418" checksum="C56606AC415DEC37" modified="2009-10-13" version="1" fragment="single">KRKRKSTTTENKKPGFFARITRRSGQGNYEQTAGDDGESGRNSHQLDNASSNGQRNNQANSSGNAGAAVDRNTSVRSVLTLPAYRQMANPNEQVLGREGERDGVDVIIDLPTAEAEEEARDNEMETLYQIRLARRQMLAEREDRRERRREARSRNDYRTLEQIRAETRLANENTTISELRTTVDQIKDSRQRSVSSVSYADVGIARHDGTRIRANSTESERVGLLSDAASLGHQRGRSGSSAVSHDDDFSSLAPARSQGSSRAGTPNDDGRAGSSPELVEADLGDETMPPPEYEDIPLNDDGRSTTPINEPPPDYPGPYRSSSQRTAERDLGSGPQNGEVGPAEQAGDGHDGSDNHGSPRGRDGAPQLPSLRISQLPEIVIEPSSAHPRDNDQRSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWU4</accession>
    <name>C7YWU4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_82786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049180.1">
        <property type="nucleotide sequence ID" value="XM_003049134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWU4"/>
    <dbReference type="GeneID" id="9666564"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82786"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82786"/>
    <dbReference type="eggNOG" id="ENOG502SNWE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027349_0_0_1"/>
    <dbReference type="InParanoid" id="C7YWU4"/>
    <dbReference type="OMA" id="RCSAQHI"/>
    <dbReference type="OrthoDB" id="3257981at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU43467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="602" mass="67147" checksum="033798AFCD0A7E88" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWX9</accession>
    <name>C7YWX9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_45554</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049202.1">
        <property type="nucleotide sequence ID" value="XM_003049156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWX9"/>
    <dbReference type="GeneID" id="9666109"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45554"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45554"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_1_1"/>
    <dbReference type="InParanoid" id="C7YWX9"/>
    <dbReference type="OMA" id="TIPNKMA"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="30"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU43489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="424" mass="45336" checksum="6E6936981F694D62" modified="2009-10-13" version="1">MPRDKAPQDSDGVSLKLAEATSSPPSGGPRAWLNVLGSFMLYFNTWGILNTFGAYQTYYESGELFDASSSDISWVGSIAAFLLLFVGIFVGPVFDRGYLRTLLLVGSFMVVFGHMMLSLCDSLWQVLLAQGFVIGIGAGCLFVPCVAIIPQYFSTRMGTALGIAASGSALGGVIYPIVLYRLIGEIGFPWTTRVIGFIVLGTLLIPIVTMRLRVQPPKIRAMVDMTTFTDVSYMAFVLNSMLAYMGLFVIFFYLSYYAAAEHITDDSLAFYLVPIFNAASVFGRTIPNKLADKTGPFNLLAPFSCVSGALMLCMMAVHSKGAITVLAILSGFMSGALIGLPPICLAVLTKDKSRLGTRIGMGYAIIALGVLISGPSGGAILSGNGNTLHWHNLWTFGGVPTCLSGLGYAAIRVSIYGAKLRVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7YX79</accession>
    <name>C7YX79_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Isopropylmalate dehydrogenase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_45520</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049251.1">
        <property type="nucleotide sequence ID" value="XM_003049205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YX79"/>
    <dbReference type="STRING" id="660122.C7YX79"/>
    <dbReference type="GeneID" id="9666233"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45520"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45520"/>
    <dbReference type="eggNOG" id="KOG0786">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_3_1"/>
    <dbReference type="InParanoid" id="C7YX79"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979:SF1">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="9">
        <location>
            <begin position="11"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU43538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="352" mass="37893" checksum="E748A22282348191" modified="2009-10-13" version="1" fragment="single">MPLIDDQRPFQVALLPGDGQGPYLASYVERTLDLIQRVRRNVSFKVSRHDFGGVALAAGAGTALPSTTLGACRQSDAVLVCGCGDPRYGIEPERGLLTLRQELEGCVNIRPVRFPSSQLVQQSSYKPEVVEQLDITFFRDLTSGVYYGRRKEAGDDGEAYDTTPYSRQTIERIARLAGTYAMQFSPPKPVHSIDKHNVMATSRLWRSVVAHVFENEFPQVPLRHVLVDTASMILSSDPLSLNGIILTENMFGDILSDQAGGILGSPDVLASAAVSAIRRGGSRGTPGIFEPFNLNPGGKTVGPLGSIQAVGLMLELSLGLAAESEALSKAIRRTLDPIELVGSDTRTVDLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7YY31</accession>
    <name>C7YY31_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_104908</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049411.1">
        <property type="nucleotide sequence ID" value="XM_003049365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YY31"/>
    <dbReference type="STRING" id="660122.C7YY31"/>
    <dbReference type="GeneID" id="9677045"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_104908"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_104908"/>
    <dbReference type="eggNOG" id="KOG2820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_0_2_1"/>
    <dbReference type="InParanoid" id="C7YY31"/>
    <dbReference type="OMA" id="NKIMGIR"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF26">
        <property type="entry name" value="L-SACCHAROPINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="10"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU43698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="439" mass="48084" checksum="1836EAE2262F468E" modified="2009-10-13" version="1">MTLSRDSTKVVIVGGGGTMGSSTALHLIRSGYTPSNITVLDVYPIPSAQSAGCDLNKIMSVRLRNKADLQLSLEALDMWRNDPLFKPYFHNVGLVDCSSSKEGIAELKEELKTIIDAGVGLDKASSWLESEDEVLAKMPWFTKDHVKGWKGLFTTNGGWLAAAKAINSIGSFLRSQGVQFGFGGAGTFKQPLLAADGSTCIGVETVDGTQYLADKVILAAGAWTPALVDLEGQCVSKAWVLAHIRLTPEEAARYKNIPVVYDGDYGFFFEPNEDGIIKVCDEFPGFTHFKKHQPFGAAHPKFISVPRSHASHPTDTYPDASEATIRKAMARFLPDFRDRKIIDRAMCWCTDTADANLLICEHPRWKNLILATGDSGRSHSFKLLPNIGKHVVELLEGTLSQQLAEAWKWRPGGDALKSRRAAPAKDLADMPGWKHDARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZ70</accession>
    <name>C7YZ70_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA-binding protein VTS1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">RNA-binding protein vts1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NECHADRAFT_62977</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA-binding protein involved in post-transcriptional regulation through transcript degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer. Binds to RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048840.1">
        <property type="nucleotide sequence ID" value="XM_003048794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZ70"/>
    <dbReference type="STRING" id="660122.C7YZ70"/>
    <dbReference type="GeneID" id="9665688"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_62977"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_62977"/>
    <dbReference type="eggNOG" id="KOG3791">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017632_0_0_1"/>
    <dbReference type="InParanoid" id="C7YZ70"/>
    <dbReference type="OMA" id="MSTVNNR"/>
    <dbReference type="OrthoDB" id="2155283at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09556">
        <property type="entry name" value="SAM_VTS1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000033">
        <property type="entry name" value="Protein vts1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050897">
        <property type="entry name" value="SMAUG/VTS1_RNA-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057327">
        <property type="entry name" value="Vts1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037635">
        <property type="entry name" value="VTS1_SAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515:SF5">
        <property type="entry name" value="PROTEIN SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25479">
        <property type="entry name" value="Vts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SAM" evidence="14">
        <location>
            <begin position="556"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="229"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="523"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024046"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00054767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEU43127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="621" mass="66199" checksum="9164D669AEAE7E52" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0D2</accession>
    <name>C7Z0D2_FUSV7</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_79851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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            <taxon>Fusarium solani species complex</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="288" mass="31132" checksum="B7CE7A80A8B01511" modified="2009-10-13" version="1">MPRPVYINVDNVHRLAVHVWTPKRGCIMKTLCTLLILAGRLLEAFAETLPSLSCAAGSEITAHPACDSFLASGDACATVLDRPGKEDCLCHQECENELRLCYRREDLGVNFDRARELWNSLCGSVITFDPTTAPPSSYEPYPDQLCQDIKTKCAEARELLRECTDYVSDTDGSKFSSCTCRPTLLREAYSCAYVGNTTCLGVGATLSNVLGYQCDNFESVIGTGLPGFSAATQTELPTLDITTAMTGSNSESTATATTTSDNASVKESPRFGAALMFSICSLFLISVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0F8</accession>
    <name>C7Z0F8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_79878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003048041.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="9671893"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79878"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79878"/>
    <dbReference type="eggNOG" id="ENOG502SS3X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="C7Z0F8"/>
    <dbReference type="OMA" id="EIGCELW"/>
    <dbReference type="OrthoDB" id="5416609at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="2"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="560" mass="63297" checksum="BF78E70F2A88ED36" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0N1</accession>
    <name>C7Z0N1_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_79951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048123.1">
        <property type="nucleotide sequence ID" value="XM_003048077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0N1"/>
    <dbReference type="GeneID" id="9671930"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79951"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79951"/>
    <dbReference type="eggNOG" id="ENOG502TE57">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_518839_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z0N1"/>
    <dbReference type="OrthoDB" id="5430299at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="525" mass="59594" checksum="0EB130A48EC78E55" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z198</accession>
    <name>C7Z198_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_69126</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048040.1">
        <property type="nucleotide sequence ID" value="XM_003047994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z198"/>
    <dbReference type="FunCoup" id="C7Z198">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="GeneID" id="9672025"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_69126"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_69126"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_11_5_1"/>
    <dbReference type="InParanoid" id="C7Z198"/>
    <dbReference type="OMA" id="RDDEWAY"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000149">
        <property type="entry name" value="MFS transporter, SP family, general alpha glucoside:H+ symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF56">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="79"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU42327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="581" mass="64686" checksum="04EA00395C22ADB7" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1D7</accession>
    <name>C7Z1D7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_50796</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU42153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047866.1">
        <property type="nucleotide sequence ID" value="XM_003047820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1D7"/>
    <dbReference type="STRING" id="660122.C7Z1D7"/>
    <dbReference type="GeneID" id="9671484"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_50796"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_50796"/>
    <dbReference type="eggNOG" id="ENOG502QR47">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004835_2_0_1"/>
    <dbReference type="InParanoid" id="C7Z1D7"/>
    <dbReference type="OMA" id="PACSFCE"/>
    <dbReference type="OrthoDB" id="4356994at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU42153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="562" mass="63233" checksum="8AE8A0A4BD329AA0" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1S1</accession>
    <name>C7Z1S1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="2">1.2.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_85894</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutamate 5-semialdehyde + NAD(+) + H2O = L-glutamate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="2"/>
    <dbReference type="EMBL" id="GG698906">
        <property type="protein sequence ID" value="EEU42050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047763.1">
        <property type="nucleotide sequence ID" value="XM_003047717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z1S1"/>
    <dbReference type="STRING" id="660122.C7Z1S1"/>
    <dbReference type="GeneID" id="9671721"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85894"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85894"/>
    <dbReference type="eggNOG" id="KOG2455">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_4_1_1"/>
    <dbReference type="InParanoid" id="C7Z1S1"/>
    <dbReference type="OMA" id="EWGSILN"/>
    <dbReference type="OrthoDB" id="5322683at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:L-glutamate gamma-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase"/>
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        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
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    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
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    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050485">
        <property type="entry name" value="Proline_metab_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862:SF1">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="89"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU42050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="560" mass="62208" checksum="A58E61CA670EBDFE" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z335</accession>
    <name>C7Z335_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_54003</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047303.1">
        <property type="nucleotide sequence ID" value="XM_003047257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z335"/>
    <dbReference type="GeneID" id="9675909"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_54003"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_54003"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_2_4_1"/>
    <dbReference type="InParanoid" id="C7Z335"/>
    <dbReference type="OMA" id="WIFNARF"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF7">
        <property type="entry name" value="CHOLINE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU41590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="51270" checksum="A9683860373D4082" modified="2009-10-13" version="1">MEKPFSVWSAMAIGASTTNTAIGIILTIGSITASGGSVTLFWGFLFMAIIGLACATSLSELASALPDAGGQYIWVAALSPPGPRRFLSYVTALLSWAGAVCTGASVCVVGPSLLFSLGSLLNPSFQQDPWMGFVAYQLTNIITLALSAFEHLLPRITKGILAFTMCLLVALFVGLFAASDERRSAKDIFTDFYNVSGWSTGVAFLIGQNGLNWGFSCLDAIVHIAEEIPDPSTNVPKALILTIIVGFVTGLPIVLAFCVNQVNYETQTSTMATVYVAFGESKAAAIAFQIAIFISAVGAMWGIHVWQSRLAWTIALNKGFPFSKHIGQVMGAPFHTPIYALIWSAAFTSLLGFLYLGSQTAFNSLVSAGILLQYASYAIPIVLLLKHGRSRLQHGPFWYPRLGLLSNIIFLCWAPIALVFYCFPYALPVEAASMNYISVVLAIVGVLIVFFWYIYARKNFSFPELGASRCIDEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z370</accession>
    <name>C7Z370_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_53829</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an important role in cellulose degradation. Shows hydrolytic activity against several glycosidic compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047495.1">
        <property type="nucleotide sequence ID" value="XM_003047449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z370"/>
    <dbReference type="STRING" id="660122.C7Z370"/>
    <dbReference type="GeneID" id="9675927"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_53829"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_53829"/>
    <dbReference type="eggNOG" id="KOG0626">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001859_1_2_1"/>
    <dbReference type="InParanoid" id="C7Z370"/>
    <dbReference type="OMA" id="VWLKVYP"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080079">
        <property type="term" value="F:cellobiose glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000011">
        <property type="entry name" value="Cytosolic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU41782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="480" mass="54831" checksum="031D7A7D9168DE59" modified="2009-10-13" version="1">MPSLPPDFKLGFATASYQIEGAVAEDGRGPSIWDVFCHLEPTRTKGASGDVACDHYHRLDEDLDLMKQYGADMYRFSLSWSRIIPLGGRNDPINEAGIDFYNRVIDGCLSRGITPWVTLYHWDLPQALHERYGGWLDVEESQKDFERYARLCYERFGDRVKHWITLNEPWIVSIFGYATGGNAPGRSSINPQSTEGDTATEPWIVGQALIMSHARAVAAYNKDFRPSQKGQIGISLNGDYYEPWDSSEPRDSEAAERRMQFHIGWFANPIFLNKDYPQCMRDQLKDRLPTFSADDMALLRSAECDFYGMNYYTSQFARHKTSPPPDTDYIGNLDELQSNKAGDPVGLESGLHWLRSCPDLFRKHLTRVYRLYGKPIIITENGCPCPGEDKMTREESVQDDYRIKYFDDHLDAAAKAITEDGAVVEGYFAWSLMDNLEWSDGYGPRFGVTFTDYKTLDRTPKKSALELRSIVDRKKVRSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z384</accession>
    <name>C7Z384_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_87861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047326.1">
        <property type="nucleotide sequence ID" value="XM_003047280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z384"/>
    <dbReference type="STRING" id="660122.C7Z384"/>
    <dbReference type="GeneID" id="9675935"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87861"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87861"/>
    <dbReference type="eggNOG" id="ENOG502R1M1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002639_6_0_1"/>
    <dbReference type="InParanoid" id="C7Z384"/>
    <dbReference type="OMA" id="TEPMIVF"/>
    <dbReference type="OrthoDB" id="5362512at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="232"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU41613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="669" mass="73725" checksum="A35ABC246F0510F6" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z3A4</accession>
    <name>C7Z3A4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_27833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047334.1">
        <property type="nucleotide sequence ID" value="XM_003047288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z3A4"/>
    <dbReference type="STRING" id="660122.C7Z3A4"/>
    <dbReference type="GeneID" id="9675946"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_27833"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_27833"/>
    <dbReference type="eggNOG" id="KOG2984">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_4_0_1"/>
    <dbReference type="InParanoid" id="C7Z3A4"/>
    <dbReference type="OMA" id="HHTEFAR"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="28"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU41621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="277" mass="30135" checksum="D9BFBD44ECDA57F2" modified="2009-10-13" version="1" fragment="single">QTVKTRYVKVNGDKLAYRRFGAKSGALPVVFLPNFRASMDIADPLLFNYIAESREVILFDNTGVGHSEGVVADSIAKQGDTAADFLAAIGVKKANVFGFSMGGGVAQHVGINYPDLVEKLVLAGSIIGNGTGTREVAPGTFEKARQPELSLEDILSLFFYPSETSEAAGVAWITRAGERQVKGENRTASIQEPGTSRHLKAILDFTQNSTYFDQIKTIKAPVLVTNGKTDVLAPTINSFLLQQQLPNAQLHLYPDSGHGHLFQFAKQWVESLVYFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z496</accession>
    <name>C7Z496_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_101219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046989.1">
        <property type="nucleotide sequence ID" value="XM_003046943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z496"/>
    <dbReference type="STRING" id="660122.C7Z496"/>
    <dbReference type="GeneID" id="9675325"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101219"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101219"/>
    <dbReference type="eggNOG" id="ENOG502SQ1Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002639_4_4_1"/>
    <dbReference type="InParanoid" id="C7Z496"/>
    <dbReference type="OMA" id="RPAQPKY"/>
    <dbReference type="OrthoDB" id="5428863at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF1">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="323"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU41276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="840" mass="95339" checksum="38DD60B26DA4E43A" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4D0</accession>
    <name>C7Z4D0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable Xaa-Pro aminopeptidase P</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_83559</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047010.1">
        <property type="nucleotide sequence ID" value="XM_003046964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4D0"/>
    <dbReference type="STRING" id="660122.C7Z4D0"/>
    <dbReference type="GeneID" id="9675729"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83559"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83559"/>
    <dbReference type="eggNOG" id="ENOG502RSI1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_4_1_1"/>
    <dbReference type="InParanoid" id="C7Z4D0"/>
    <dbReference type="OMA" id="NTFPMIS"/>
    <dbReference type="OrthoDB" id="5083480at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd01066">
        <property type="entry name" value="APP_MetAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050659">
        <property type="entry name" value="Peptidase_M24B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46112">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46112:SF2">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="3">
        <location>
            <begin position="15"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="2">
        <location>
            <begin position="164"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU41297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="405" mass="43280" checksum="DA4193D2C2D66AF0" modified="2009-10-13" version="1">MALSILPTQADIRSRVVRVQNAIKGAGMDLLVLHGTANHRFFTGLDGLPDVRPIFLVIRPNAAPAFISPRIEAPIIRTKCTQEIVAEWGDWDEPGMYRSFGDALASYIQKVAPKAAMIGLDSNTVTAANLELLKNKLASADIVDASTLISQVRRDGDAAQTRILRSCADVAAQKFKGAREATAPGVPEWRVALRGYTAAVEQASKYLEGDENNSPLGSSFTVVGSGRIRSAHAHSVASNRIMRDGELVQICCCTPTLVGHDMCFDRPIAVGTKELPEDVLNVLSAAREASAAAWKVVRAGVRAEEVHAAAAEVIARRGFTEGMQHGTGRSIGCGGVGFRIMEGEQTVLQEGDVVGIEPGVYQYGVGGARYGDTALVTTKGCEMLTPFDLGRDIQADQAAIRRARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4D4</accession>
    <name>C7Z4D4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_66482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046042.1">
        <property type="nucleotide sequence ID" value="XM_003045996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4D4"/>
    <dbReference type="STRING" id="660122.C7Z4D4"/>
    <dbReference type="GeneID" id="9668401"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_66482"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_66482"/>
    <dbReference type="eggNOG" id="ENOG502S6UJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012849_2_1_1"/>
    <dbReference type="InParanoid" id="C7Z4D4"/>
    <dbReference type="OMA" id="CCHALDE"/>
    <dbReference type="OrthoDB" id="2240312at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000500">
        <property type="term" value="C:RNA polymerase I upstream activating factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039601">
        <property type="entry name" value="Rrn5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28079">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28079:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU40329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="527" mass="60209" checksum="61566B80E392D1B5" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4N6</accession>
    <name>C7Z4N6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase</fullName>
            <ecNumber evidence="5">2.7.8.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">GlcNAc-1-P transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">N-acetylglucosamine-1-phosphate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">NECHADRAFT_91141</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UMP</text>
            <dbReference type="Rhea" id="RHEA:13289"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.7.8.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13290"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 4 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.15" evidence="5"/>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046093.1">
        <property type="nucleotide sequence ID" value="XM_003046047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4N6"/>
    <dbReference type="FunCoup" id="C7Z4N6">
        <property type="interactions" value="507"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z4N6"/>
    <dbReference type="GeneID" id="9678472"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_91141"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_91141"/>
    <dbReference type="eggNOG" id="KOG2788">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029942_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z4N6"/>
    <dbReference type="OMA" id="LPHFNAR"/>
    <dbReference type="OrthoDB" id="10262326at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003975">
        <property type="term" value="F:UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06855">
        <property type="entry name" value="GT_GPT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033895">
        <property type="entry name" value="GPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571:SF0">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EEU40380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="467" mass="52456" checksum="422E851383A4C84E" modified="2009-10-13" version="1">MAVASTTSLSRHETLTLLVLSGASLAVLANTFHGDGEPLIASLSLSLLAFSICYAMIRWLGPTFMRAGFRGRDMSKLHRPDIPECMGAVCAAVYLITVMVFIPFPFYKDIVAATSGGGNRDVVVKLEEVNEGRFLHRFPHNKLASYLSAIISLQTIALLGVGDDLFDIRWRHKWWIPGLASIPLLVVYFVDFDVTSIVLPVQLQPYLGELFDLGPFYYVYMACVAMFCPQSINMLAGINGIEVSQCVVVALLLVFNDCLYLFTPYPHPATDSHLFSLYFLLPWIGVSCALLCHNWYPAKVFVGDTYCYFSGMVFAVVGILGHFSKTLGLLLIPQLFNFLYSCPQIFGLIPCPRHRLPRFNARTGLLEPSVTPWSPERQPHPLVAQVLHLLAKLRLLKVTTDDKGQFVETSNFTILNLWLVWRGPLREDRLAFEVTMLQLVVGLFGLFVRHRLALLVFKEDNWGTVHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z5R7</accession>
    <name>C7Z5R7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acriflavine sensitivity control protein acr-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_34199</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046281.1">
        <property type="nucleotide sequence ID" value="XM_003046235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z5R7"/>
    <dbReference type="STRING" id="660122.C7Z5R7"/>
    <dbReference type="GeneID" id="9678103"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_34199"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_34199"/>
    <dbReference type="eggNOG" id="ENOG502SI0U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020030_3_0_1"/>
    <dbReference type="InParanoid" id="C7Z5R7"/>
    <dbReference type="OMA" id="QMFWGYL"/>
    <dbReference type="OrthoDB" id="5130013at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF51">
        <property type="entry name" value="ACRIFLAVINE SENSITIVITY CONTROL PROTEIN ACR-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU40568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="52672" checksum="812496DCA1031B15" modified="2009-10-13" version="1">MNKIQKGDTTSTLQASWPSIVSTTQPPFASSKPNSPRPLPLSLIDPLAQDLDYRSRRYLDYFATDVCRDLVVYDIPNHNPFHDLIPMAYQHPILLQAIIASSALHMSNACQRSSRSSSISTTMTSTQSSTSSLSMGPSMTSRPETFHDALKAKQQALCLLKSTLKDIASADVDVILAVVLFLIGFELIDSGRGSWMFHINGARPIIEKLMASGLGTETALSPLRSWLMSNCLVYDLLGSSFANSYLPHSGGLSMSAMSLLQDAEGNHCSSFPAALLALIQTGAQLLKTKDVSTSPDALMNLAQQDALRLLHAAKSFDPAVWAIDLQPRSPADDPLHRTIIASAHRAAVCIYLSRIALALWPSTLLPDDLEILAAEIITHLSNVRPGDALFTATAWPAFIAGLETVDPMKRAWVVKRFQELWEMEPWGLTRGALEALRTIWDGRNNEDALAGSIDRLHEQEENWNWIEKLKNMGTDWLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6A9</accession>
    <name>C7Z6A9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_76038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045810.1">
        <property type="nucleotide sequence ID" value="XM_003045764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6A9"/>
    <dbReference type="STRING" id="660122.C7Z6A9"/>
    <dbReference type="GeneID" id="9668569"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_76038"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_76038"/>
    <dbReference type="eggNOG" id="ENOG502SJWZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019524_2_0_1"/>
    <dbReference type="InParanoid" id="C7Z6A9"/>
    <dbReference type="OMA" id="YWREAPE"/>
    <dbReference type="OrthoDB" id="4314040at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU40097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="473" mass="52955" checksum="5C12F279B4AD5727" modified="2009-10-13" version="1">MAGVPSSKGCRACVRQKKKCDQVKPVCARCARLKIPCIGAGEQKWKFKPVSFQPVAFQPAVVEDIPKKPRRSIKASIPPVPENIITSIAGRFIAALEVSDIRYSLSSYGDFLEHIPRRLGRSEALDASVKALVSAFPYHYTRHLPQDALANYIDALKALRICLNCPDKRLAPETLSAIYIIMICQGWIGRSDDYVRSHGEILAHLASSAIVQNWKDTFELQLLETLFVPLILEAMVNPAITMESWFLLVDYCIPQASFEKAHGLRVPSVEAQKLIRMPVFFHSPMLYIDEIKSAYQEMQQDLPGIRQYLSNLDRNESTWGNRAKLSHKFRVVHALLLTLAIPLNSLLRTLYPDDNVLFQEAIALTNEFIALAQHASQHRPLGATYIPPCLAGVWAITDSLHVQQAELQRLMEEYQPDSPLINWMEQAVWLKASHKTLLDQVAGRASSEGSWDGHLSMVHCMAGFGPSGSCLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6B9</accession>
    <name>C7Z6B9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_103320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045817.1">
        <property type="nucleotide sequence ID" value="XM_003045771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6B9"/>
    <dbReference type="GeneID" id="9668651"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_103320"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_103320"/>
    <dbReference type="eggNOG" id="ENOG502SJUF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011409_12_2_1"/>
    <dbReference type="InParanoid" id="C7Z6B9"/>
    <dbReference type="OMA" id="VMGFCPL"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU40104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="492" mass="55571" checksum="F08AD9E81F3DBE6C" modified="2009-10-13" version="1">MARIGSQKVKTGCLTCKSRKVKCDEAWPKCKRCTSTGRTCDGYRPPPVGSLSWDVLLRPQPRILASADGRETRSLSFFHRAVAPVISGPFDGSFWTHFVTQVAHAEPAARHAVMAISSLYENFDPSVSGVATMDTFALFHYNQAIKRLVEDPSPDVDLVLLVCILFICIEFLRGDRHTAINHAHHGVQLLNQAGKSSKLTAVFSQMSVHSGTDFPHLTTHAFDNNAANPLFRSLIEAQHALDLLGIRMFRLIREVHPYRLGMNPARPPQEILDEQFFLGRDMTAWGDAFARFQASRSPDRREDVISLALKTRQMVGRIWVAECLNKEEMGYDARKSEFEEIVRCARLAAEQNDSLDREGLPRPKFMFDLGFNPMLHFLVLKCRYFNLRVEALALLKKLSYARESLWDTSLVYDVSKRIIEVEHNVKLPTDKIIDDETLPTDLERSPEDKETLARRPINLIVAKPGGGIDVRRDFIGEDVSHSISLNLTLIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6K0</accession>
    <name>C7Z6K0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Presequence translocated-associated motor subunit PAM17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_66132</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the PAM complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the PAM17 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045858.1">
        <property type="nucleotide sequence ID" value="XM_003045812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6K0"/>
    <dbReference type="FunCoup" id="C7Z6K0">
        <property type="interactions" value="49"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z6K0"/>
    <dbReference type="GeneID" id="9668055"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_66132"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_66132"/>
    <dbReference type="eggNOG" id="ENOG502S1B1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068297_0_1_1"/>
    <dbReference type="InParanoid" id="C7Z6K0"/>
    <dbReference type="OMA" id="MIFGFDP"/>
    <dbReference type="OrthoDB" id="5970083at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013875">
        <property type="entry name" value="Pam17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021:SF1">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08566">
        <property type="entry name" value="Pam17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="147"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU40145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="244" mass="26887" checksum="0FBB279AE26F5142" modified="2009-10-13" version="1">MASSPLKTFVLRRPVTGVICSSPKAPFSTFPAASCLARSPLRKQCLAPVVSVPKAFARAASSGKPDLASAAQQSLNATPGQNNAHDFAQDPHHALDWNSFFKLRLKRRRYQLLFSITNGMFCGGAGAVVLSTGVAEPVITQIPLDPFMTLGIMTFAFSGLGWLIGPSIGNQFFYALNRKWKKQMTQKEAEFFERIKKHRVDPTNSSAANPVPDFYGEKIQSVAGYRQWLKDQKAFNKKKTANFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z889</accession>
    <name>C7Z889_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_39233</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045541.1">
        <property type="nucleotide sequence ID" value="XM_003045495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z889"/>
    <dbReference type="GeneID" id="9672442"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_39233"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_39233"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_1_1_1"/>
    <dbReference type="InParanoid" id="C7Z889"/>
    <dbReference type="OMA" id="NFWLLII"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF153">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00230)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="58"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU39828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="478" mass="52364" checksum="B0BF0FAF41C0A4F8" modified="2009-10-13" version="1">MTARTELELENGTSPTPTPTEKEAQSGSSQSDTGPIDWDGPDDPEMPLNWPKSKRWINTMAVSTLTLLTPFASSMIAPAVQLIMDDMSETNPNIGSFSVSIYLLGYAFGPLFLAPLSELYGRLPVYHICMFLFLLTNIACALSVNMPMFIIFRLLTGLVGACPLTLGPASVADCFRQVERGRAMAIWNMPVLLGPSLGPAVGAYVSRSLGWRWNFWLLVIMKETHHPTLLKKKERKLQKLHGTEQVSSTLASDTKNQLLKKSLARPLKMLFLSPIVFGLSLLTAIAYGTLYLLFTTVSEVFRTRYGIVTNVGLVYLGFGSGQIVGLFVFGLLSDAIVKRLAKKGGEMKPEYRIPLMIPCSAIIPIGLLVYGWTAQFRVFWFVPIIGTFLIGFGMITVFSSVSTYLVDAFPVYAASATAANTVLRSVGGALLPLAGPKMYEALDQGWGNTLLAGISLGMIGMIVMSYKYGERLRTKVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z947</accession>
    <name>C7Z947_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_43202</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045072.1">
        <property type="nucleotide sequence ID" value="XM_003045026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z947"/>
    <dbReference type="FunCoup" id="C7Z947">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="GeneID" id="9673083"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_43202"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_43202"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_1_1"/>
    <dbReference type="InParanoid" id="C7Z947"/>
    <dbReference type="OMA" id="ARESIPW"/>
    <dbReference type="OrthoDB" id="3357846at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="44"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU39359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="498" mass="55154" checksum="118637AB46D4E2AD" modified="2009-10-13" version="1">MAVRVWWLLGGECCDTGSDHVLTAIRESSDDPENPHNWSTARKTGVSFLIWHCHSMYTFTIYCGSSIYVPSTEQVTKSFGVSETVASLGLALYVLGYGLGPLLFSPLSEMPYIGRNPIYIITFAIFIILSVAAALCETFAGFLVVRFLQGFFGSPCLATGAATLTDMFSVIYIPYSLAAWSGAMYCGPALGPLLSGFSVTAKSWRWSMWELLWLSGLMFIPLFFLLPETSTPTLLYYKAKRLRKETNSTRYVSEAISSNTASRKDVVKMALIKPFEITLKDPAIAFVNIYTSFTYGIYYSFFEVFSLVYPKIYGMNLGESSAVFVCVLIACLLGAFQYCSWYRLFIEKRFKKLGTFDSPETYLRPGLGGVFGVTAGMFLFGWAARGSIHWVVPTIGIVMYCGCGFVVGIGIFIYLPLSYPQYAASLFAANDAMRSSFAAAAILFGRPLYINMGVAKGCSLLGGLSVFGVVGFWYLFVYGEKLRKKSRFTVHEESRDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z9H3</accession>
    <name>C7Z9H3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial import receptor subunit tom-22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_62037</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom22 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045219.1">
        <property type="nucleotide sequence ID" value="XM_003045173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z9H3"/>
    <dbReference type="FunCoup" id="C7Z9H3">
        <property type="interactions" value="284"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z9H3"/>
    <dbReference type="GeneID" id="9673380"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_62037"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_62037"/>
    <dbReference type="eggNOG" id="KOG4111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094333_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z9H3"/>
    <dbReference type="OMA" id="LVWIVTT"/>
    <dbReference type="OrthoDB" id="10016939at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22884">
        <property type="entry name" value="TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005683">
        <property type="entry name" value="Tom22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04281">
        <property type="entry name" value="Tom22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU39506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="16936" checksum="B7A3DB6DE3473CEE" modified="2009-10-13" version="1">MVTLTEVEDEHFQHAQAGPDIEDDDEDYTDTDSEISNDSDYDPSEETLAERLYALRDIVPPTTRSWFSSKANAISSATWSVLSFSGKTAWVVTTSALFFGVPFALSFAEDQQLTAMEQEYNMRQTGGELLTAGAEQNTAEKVGAALDGKPSQPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZA61</accession>
    <name>C7ZA61_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_70521</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045334.1">
        <property type="nucleotide sequence ID" value="XM_003045288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZA61"/>
    <dbReference type="FunCoup" id="C7ZA61">
        <property type="interactions" value="289"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZA61"/>
    <dbReference type="GeneID" id="9672289"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_70521"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_70521"/>
    <dbReference type="eggNOG" id="KOG2742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_3_1_1"/>
    <dbReference type="InParanoid" id="C7ZA61"/>
    <dbReference type="OMA" id="KPCFEYA"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF5">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="3">
        <location>
            <begin position="150"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU39621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="37142" checksum="35DA6E856BC36B61" modified="2009-10-13" version="1">MAPIGVAMIGGGLFAKQEHMPALMKCDNFALKAIYSRSLKSAQETAALNTRESTPDLYSADAGPGKSYDDLLARDDIAAIILALPIMSQPAHIEAALTAGKHVLAEKPLAPTVEAGKKLLEFYRRTAEANGATFAIAENFRFKPSFEYAAVEAAKLGSVQQFNVRVLGYMGADTQWYATAWRAKPEYQGGFLLDGGVHFAAATRMLLTTRAADVRAQTALTQPHLPPIDTVNAVVRLESGVSGVYQQSAGSRLSAFDFDFSYEKGTVSVSGDKVTVTPLEGEAVVKEFERTSGVSEEVEAWGKALVAGKPDERQSVEKALGDLEFLEQMFESGSNGGETKKYELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZA80</accession>
    <name>C7ZA80_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_82006</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045345.1">
        <property type="nucleotide sequence ID" value="XM_003045299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZA80"/>
    <dbReference type="GeneID" id="9672300"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82006"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82006"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_2_1"/>
    <dbReference type="InParanoid" id="C7ZA80"/>
    <dbReference type="OrthoDB" id="5141738at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF74">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="39"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU39632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="478" mass="51767" checksum="35CCCDFADE373CC5" modified="2009-10-13" version="1">MNGISLISGPGHESASKRLGATIDVVDPIESKVHAAKFSTATGLACAFNGSFGTSMPSGALDAISSHFRVYDQVQLTLLNSLNLAGFVVGPLFFGPLSEYIGRRPVMISTFFGYLVFMLACSGAPNYTALLIFRLLCGLNAAAPMAVIGGLYADVLDDPSERGTAMSLYLAISGIGPLLGPFVSGFASQVSWRWAFWAATLIAVPTLPLVMTLPETFAPVLNNREIHKRRKNGDEGVEEAQITELHPFDAREIFLRPVVMMATEPILSLSSLYVTLANSLFYIAFQAYPLVFEGIYHLRTEIAGLTYLPIALGTVVAFLGFMVYTPWYDRSKAAGKPWAQREINRRLPIACFAAPLLVIALFWFGWTSKPSISPYVPAIGGFFSGAGFLLIFMSILNYITDVFREASASAHAGAGCMRSLGAIVIPLAAGPMYDRLGVHWAQSLLGFLSLVMGAIPFFFMKYGERLMQKSKAAQGVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZAN7</accession>
    <name>C7ZAN7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_43674</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045424.1">
        <property type="nucleotide sequence ID" value="XM_003045378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZAN7"/>
    <dbReference type="STRING" id="660122.C7ZAN7"/>
    <dbReference type="GeneID" id="9672379"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_43674"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_43674"/>
    <dbReference type="eggNOG" id="ENOG502S5YP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079104_1_1_1"/>
    <dbReference type="InParanoid" id="C7ZAN7"/>
    <dbReference type="OMA" id="ICCYFGS"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="4">
        <location>
            <begin position="11"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU39711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="283" mass="31845" checksum="125DC2F55568EF11" modified="2009-10-13" version="1">MSLTVGIAGLSGRFGRLVGEILLKRPASEVKLRGFCREPRKLAKSLSGNSRVEVIQGSAFDSSAARTFAMGCDVVVCCYLGDDKLMIDGQKLLVDACEAEGVSLKDHLDTKEHIKGVHVMVGAFMDTFFTAYFDSWDPEKKVFTFWGTGDEVLEFSSYRSSAEYTASVVLDRKAVGVQKFLGDRLSIKQILQLFDSQYGFKPELNLVGSKEDLYKHMYEVQEKEPDNVFKYMVLFYKYYLINGQTHLGAIENSKYPDIKPETFRDFLSRHTVGQLSQAVEALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBF7</accession>
    <name>C7ZBF7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fucose-specific lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_83163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044443.1">
        <property type="nucleotide sequence ID" value="XM_003044397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBF7"/>
    <dbReference type="GeneID" id="9670755"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83163"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83163"/>
    <dbReference type="eggNOG" id="ENOG502SBY3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_900275_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZBF7"/>
    <dbReference type="OMA" id="AHTSEEC"/>
    <dbReference type="OrthoDB" id="5367135at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU38730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="31423" checksum="FE27FD86FC93E60F" modified="2009-10-13" version="1">MSSQVKTIVRVLRSAGSITLGNGNLVLLSIEAGRLVEKIYDGDDLKDQRLIADNVTCPNSQQVFVLYVDQDDQIRASEFDSDSEEWDDADLGDIDVTVHPDSHLAIANIHSASLVFYQGADGVIKSINYDQEGNQWTEGFPVPGSAAVGTPISAYSTDKALAVSFIGQDKSVHVHSRDFESGEWSESTLPGTWDDSVTSIIVSQDVETGSFEAFALVGTTIDHIKKDGTRAALGSIQNGDFVPATKAEAGDVYGNNYGIIQNYWNYGGGYGGGNYVYMSPPVYGGCRPRWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZC64</accession>
    <name>C7ZC64_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Late endosomal/lysosomal adaptor and MAPK and MTOR activator domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_66898</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698918">
        <property type="protein sequence ID" value="EEU38315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044028.1">
        <property type="nucleotide sequence ID" value="XM_003043982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZC64"/>
    <dbReference type="GeneID" id="9670456"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_66898"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_66898"/>
    <dbReference type="eggNOG" id="ENOG502SGDI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108580_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZC64"/>
    <dbReference type="OMA" id="RIVRYQH"/>
    <dbReference type="OrthoDB" id="5299893at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071986">
        <property type="term" value="C:Ragulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001919">
        <property type="term" value="P:regulation of receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028209">
        <property type="entry name" value="LAMTOR1/MEH1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15454">
        <property type="entry name" value="LAMTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01262">
        <property type="entry name" value="LAMTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4" id="KW-0564">Palmitate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU38315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="17674" checksum="33B3AAAC9A46526A" modified="2009-10-13" version="1">MGACASCLGRRNGDAYDEEEENRLLYDDANGIQYGSFGDQSLNGENDTLEAQRENEALQRVVAKTSNNMVDIFDIAPQDNAPRGTTTPFAYAGQGARLARYQHLVSKLSNQGESPANANGVKVDWIPEDETIEMQKNGPASIKTLESDEGPLVGTFADAAAAMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCH4</accession>
    <name>C7ZCH4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_34524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698918">
        <property type="protein sequence ID" value="EEU38368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044081.1">
        <property type="nucleotide sequence ID" value="XM_003044035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCH4"/>
    <dbReference type="GeneID" id="9670303"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_34524"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_34524"/>
    <dbReference type="eggNOG" id="ENOG502QU66">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051050_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZCH4"/>
    <dbReference type="OMA" id="NGFNMLT"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050114">
        <property type="entry name" value="UPF0173_UPF0282_UlaG_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546:SF9">
        <property type="entry name" value="L-ASCORBATE-6-PHOSPHATE LACTONASE ULAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546">
        <property type="entry name" value="UPF0173 METAL-DEPENDENT HYDROLASE MJ1163-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="28"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU38368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="270" mass="29643" checksum="CE87EEFB817CF1F6" modified="2009-10-13" version="1">MPLPKINADVNITHIGTATAILQINGVNLLTDPFFSPAGTQWDRGVVILENSDTPAMALHDLPAVDAVLLSHEDHPDNLDELGRQLLDGRRVITTMDGAKKLSPRPDVRGISPWETLPLHVGGQQFSITGVPCQHVPGQECTGFIITSPTFGEMDGLPNAIYFSGDTIYFEELTEMRNKFHISIAIFNIGAAIVAMPDGTKKQITMCGKQASRLFREIGADVLVPMHYESWGHFTENGHKLSEVFEKEGISEHVSWLEPGVRKIISTEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCN0</accession>
    <name>C7ZCN0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_77109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698918">
        <property type="protein sequence ID" value="EEU38396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044109.1">
        <property type="nucleotide sequence ID" value="XM_003044063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCN0"/>
    <dbReference type="GeneID" id="9670331"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77109"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77109"/>
    <dbReference type="HOGENOM" id="CLU_079677_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZCN0"/>
    <dbReference type="OMA" id="EWRIRSE"/>
    <dbReference type="OrthoDB" id="5022060at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="317" mass="34831" checksum="728B20FA6AD0050E" modified="2009-10-13" version="1">MVRRGSIDTYHCEPCLPQKYFTRSVSRSCANQSSLATQPGDHVPLVEEVSRAQVLTPESEVKDPISSVHEDNGQMVSRLFGLITQFWSLVIQDEALPLSQGQDEARQGPVSPPTTVADDITSREECSDSPNSSPEFDGVDELPSDAAISDDEELEARDCTPGPRDGTNQTTFNLENLLLGEELKRLRVWKTAFSNDDLDRLPFIKHEVAQGVLKCLTGVANTLIKSYSERQALLKSEDLAESLQHLIKQIESKISVASVEDDAMTDCDGFSMTQGSTCTVEEETPLEALRFDIGRLQMLSQSLRLGLSNGIIVTVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZD20</accession>
    <name>C7ZD20_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_48261</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698919">
        <property type="protein sequence ID" value="EEU38141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043854.1">
        <property type="nucleotide sequence ID" value="XM_003043808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZD20"/>
    <dbReference type="GeneID" id="9670216"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_48261"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_48261"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_4_4_1"/>
    <dbReference type="InParanoid" id="C7ZD20"/>
    <dbReference type="OMA" id="GMMTLFM"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU38141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="54364" checksum="04867F4CC3622E86" modified="2009-10-13" version="1">MLGFSRFKVPSALAPAGSKQERSLVRRLDMFLLTFGCFAQITNDFRSLDQSNIQNAYVSGMKEDLHLWGNELNYFTTYFNIAYCVMLIPSQIIITYVRPSVWLPSLEVVWGVITGLSAITKNAKQVYILRVFLGLCESTAYPGMITLFMSWYTPLEMAKRIGFYHSCQAIGQIISGAMQAAIVKSLEGRHGLSELTKQNRWLFVVNAIITVVQGAAGYFMIPDYPNNPNPRAIWFKRTHAELAMHRLDREGRVDIKPITWAAAKRTFTNWLVYVITVMYIAMVVGTLGYNYFNLFLKALTNSDGTRRWSTEEVNLIPIGGSVITVHAVWIWAFLSDILKTRWALIVTQAGIAVIVGIILTIWTTNPTGTPVSSAYAGYFLSTLSLGTAPLVWTWLSDLAPQEPEERSLTVGVAIAGYYAVSAWSQVLVWPAKQAPYYKHGWQSSIGLCSFVIIVAVTLRVIELKVILVSLVTQKRSLEHLTNVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZD31</accession>
    <name>C7ZD31_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_48165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698919">
        <property type="protein sequence ID" value="EEU38148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043861.1">
        <property type="nucleotide sequence ID" value="XM_003043815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZD31"/>
    <dbReference type="STRING" id="660122.C7ZD31"/>
    <dbReference type="GeneID" id="9670223"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_48165"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_48165"/>
    <dbReference type="eggNOG" id="KOG4176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052246_1_1_1"/>
    <dbReference type="InParanoid" id="C7ZD31"/>
    <dbReference type="OMA" id="PYKEFPE"/>
    <dbReference type="OrthoDB" id="271595at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032451">
        <property type="term" value="F:demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070988">
        <property type="term" value="P:demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032857">
        <property type="entry name" value="ALKBH4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12463:SF1">
        <property type="entry name" value="2-OXOGLUTARATE AND FE-DEPENDENT OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12463">
        <property type="entry name" value="OXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="1">
        <location>
            <begin position="82"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="233" mass="26903" checksum="4DA49299AD05F582" modified="2009-10-13" version="1">MEELPTKPSGILMQKDFITPEHEAKLVNLFQHELDWPARSGRLSLHWGYTFSYKTFGIDEDIPFKPFPDWLVPLLPTTEGRSPDQVCLQHYAPGTGIPPHVDTHGAFDQLYALSLGSPLFMQFLDKETGEKTEVDLLPRSMMQMSGDSRLHWTHGIKSRKTDILPDGTVRPRKDRWSLTYRWLREGGECECGNEKLCDTAQRRKGVEREYRWKQYEEDVKKNEKTTGHIGLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDB3</accession>
    <name>C7ZDB3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_101499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698919">
        <property type="protein sequence ID" value="EEU38190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043903.1">
        <property type="nucleotide sequence ID" value="XM_003043857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZDB3"/>
    <dbReference type="GeneID" id="9670064"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101499"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101499"/>
    <dbReference type="eggNOG" id="ENOG502S2CP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027502_2_0_1"/>
    <dbReference type="InParanoid" id="C7ZDB3"/>
    <dbReference type="OMA" id="YLRWWFL"/>
    <dbReference type="OrthoDB" id="6431331at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37471:SF1">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37471">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="53779" checksum="04B3C90C2412ABBF" modified="2009-10-13" version="1">MYALHPSNSLSSPEKTASVLSKGTFYAFIYRPYLRRLKRNAVHPSPLSREERRVLFDRCFRNVSSPESYLTWWFLGADPDDIRRDNIKEFLLWAFFERGDGSVDEPDEAVDEELEQYVTLLEERLGRKIPSGRGNVQSLRLTLDKITATYRGLAWYVIVFFVDQLTHLAFLWHGFEYYRRPRSSAIRVFPPRPQELWPGRTSPSSQLSYWHRPHTAEGQLPVVFFHGIGIGLWTYVQFLAGLHKTDDKKRSVGVIAIEILPISFRLTSAIPDKAEFLSQVTAILDYHCWENVALVSHSYGSVLTTHMLHSPSLQHRVPSVVLIDPVTIMLHLPNVAYNFTRRRPKRANEWQLWYFASTDPGVALCLGRHFFWRENILWKEELLTSLGDSGFKRDVAVTLAGRDLIVDTASVAEYLEDDAETCVEGDEGGVQVVVFPKLDHAQVFDDAPSRKTLTQLVRSRCKSGRLALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZED6</accession>
    <name>C7ZED6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_53378</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698921">
        <property type="protein sequence ID" value="EEU37655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043368.1">
        <property type="nucleotide sequence ID" value="XM_003043322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZED6"/>
    <dbReference type="FunCoup" id="C7ZED6">
        <property type="interactions" value="152"/>
    </dbReference>
    <dbReference type="GeneID" id="9665372"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_53378"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_53378"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="InParanoid" id="C7ZED6"/>
    <dbReference type="OMA" id="VKSWWFF"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF103">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="29"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU37655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="483" mass="54534" checksum="F472CB2133244FF8" modified="2009-10-13" version="1">MSDKHDCGTVDTLSPGDEKKLVRKIDLRLMPLLIVSYGLQYLDKTSLAYSAILGLREELHLKGQQFSWASSIFYIGYLVASYPISLGFVKFPLGKYLSILMLIWGVVLTLHAVASNYASLMVLRLLLGVFESAISPGFSLITGMWYTPHEHVSRHSFWFAGNASASMIGAMIAYGILGYDGHFAQWKMLFLIFGLITIAWSIFLYFFLPDSPSNATFLTPSEREFASLRPKKFQRTTQTKKWDRDQFIETMKDVKAWWFFFFSFVICVPNGGTTSFSTIVIKSFGYDEYQTILMGLPASAFQLTTVLLVAIFTSYVRKSRHIALVLTYLMAIGGILMIKLLPNEEKLARLAGFWLIMAVAPAFPLMMSLSASNIAGFTKKSTVMAMIFLGYCAGNLSGPQFFISTEAPNYHTAYTTILACFAITIVLVVAMRFYLAWENNRRDKEQGVQRDPEETRQVDLNTDGTLLDVDETDVQNRNFRYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEL6</accession>
    <name>C7ZEL6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_87536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698921">
        <property type="protein sequence ID" value="EEU37616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043329.1">
        <property type="nucleotide sequence ID" value="XM_003043283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEL6"/>
    <dbReference type="STRING" id="660122.C7ZEL6"/>
    <dbReference type="GeneID" id="9669318"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87536"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87536"/>
    <dbReference type="HOGENOM" id="CLU_567516_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZEL6"/>
    <dbReference type="OrthoDB" id="5125733at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF8">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="57"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="481" mass="54093" checksum="C398B86BB2770590" modified="2009-10-13" version="1">MLVEIASRPSIQESTLAQRQRAGLITRRLYQLFFLISRCSRCRLAVTFILRSKNIILAVRKGAKTLPGTIVDAIEVSVRLGIYYLWIDSLCIIQDDPEDVAREINKMADIYQGTTVTISAASSSCYRDGFLNTRQAHVQSKPKFKFPLTCLDGKLSTVFLLLHQSGYPYRDWVPGPINSRAWTLQEHLHWFCKETRASDGGLSLEQAKPSPFDVTMLSFSMGRAAITSTSWELSWKDLLSSYLFRGLTNPMDRLSAISAVGEELARVNHTSFVAGLFKATFAHNLCWNQVRSSPIQPRPATYRAPSWSWAAMDGPILLSEEHQDYTIMVDILDCQVILLFPQAKHGPIGSAYLALLGWVAPAILSAKPPGQHRRIMMVTAEWWEVVDEKDLDATDPELEKGEPISIWLIWMLRAAPPAACLMFSGLMVVPDGTSTERFRRIGYHSSRGAQALETGYDRGLGTRNQHKLTWSAFQRRLITIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZGT8</accession>
    <name>C7ZGT8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_55702</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-A beta-lactamase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698926">
        <property type="protein sequence ID" value="EEU36754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042467.1">
        <property type="nucleotide sequence ID" value="XM_003042421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZGT8"/>
    <dbReference type="GeneID" id="9669818"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55702"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55702"/>
    <dbReference type="eggNOG" id="ENOG502RMK4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_11_1_1"/>
    <dbReference type="InParanoid" id="C7ZGT8"/>
    <dbReference type="OMA" id="KESYHPF"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF17">
        <property type="entry name" value="(LOVD), PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="7"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU36754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="343" mass="37481" checksum="7DEC189D7C27E950" modified="2009-10-13" version="1" fragment="single">KGQLKEEKGQQITLDSTFWGFSCTKLLTTIAVLQCVEKGLIGLDDLVGSVLPELENPDIIKAKPDGLFELVPAKNKITLRHLVTHTSGLSYDAMHPILVAWRKSRGEPPLVMSGKVAEAFTLPLLFEPGSSWVYGSGLDWVGVLVERLNGNTKLAAYMENNLFKPLGLRSSTFHPSTRPDILTNLAQMWHRADTGELAPIPSPYPLDAQDDSGGMGLITSTSDLIAILQDLLKEKPVLLKPDSAAAMFTTQFETRTRQYEGLMGQEVRSQLTGDDTGHPEVAFSLGSLVIQGNVPNLPSKTLTWNRMPNISWFVNRDRDLGAVYVSQVLPAGDAKSVGLLGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHB2</accession>
    <name>C7ZHB2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_51812</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698927">
        <property type="protein sequence ID" value="EEU36721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042434.1">
        <property type="nucleotide sequence ID" value="XM_003042388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHB2"/>
    <dbReference type="FunCoup" id="C7ZHB2">
        <property type="interactions" value="479"/>
    </dbReference>
    <dbReference type="GeneID" id="9669674"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51812"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51812"/>
    <dbReference type="eggNOG" id="KOG0764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_6_1_1"/>
    <dbReference type="InParanoid" id="C7ZHB2"/>
    <dbReference type="OMA" id="CLQYADH"/>
    <dbReference type="OrthoDB" id="10266426at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000075">
        <property type="entry name" value="Nicotinamide adenine dinucleotide transporter 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF1">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06780)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="19"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="124"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="242"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU36721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="40920" checksum="BADDE5330819DD50" modified="2009-10-13" version="1">MPSPRAPRSPLETWATTATQGQLNAFSGAVGGFASGIFTCPLDVIKIRLQAQGSLVPVRFVSKSRKHELYRGLVQTGRVIWRGEGMRGMYRGMGPLLLGYLPTWAIWFTVYQHSKVTLPQAYREPNSVNILSSIAAGTASTIVTNPIWTVKVRLMSQAYRPCRSRLFRKKRIYRPHWHYHSTLDTAYKMYTTEGMGAFYSGLGAALLGLSHVAVQFPTYEYLKTKFTGKGMGAPRDDEAEWVSILSASVLSKIAASGVTYPHEVIRTRLQTQRRPVPGAEFLEGLGGFTRLRGIGLSGMVLQAKYRGIVDTFHTILREEGWRALYNGMGVNMARSVPAATVTMMSYEYVMSSLLRIKDDANDGLDEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHJ6</accession>
    <name>C7ZHJ6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_81267</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698928">
        <property type="protein sequence ID" value="EEU36479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042192.1">
        <property type="nucleotide sequence ID" value="XM_003042146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHJ6"/>
    <dbReference type="GeneID" id="9669223"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_81267"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_81267"/>
    <dbReference type="eggNOG" id="ENOG502SS51">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054422_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZHJ6"/>
    <dbReference type="OMA" id="GICETEI"/>
    <dbReference type="OrthoDB" id="3547571at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002987107" evidence="3">
        <location>
            <begin position="21"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU36479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="312" mass="33153" checksum="2FC7B4BEC6E5D8DA" modified="2009-10-13" version="1">MSRVFWFLLTMFHSLSLAHAIPSVTETPPIGKRLLARAITTEYSTCGYAKGDPDKPRTAEPGHKCLLNPKNKLFAYCDVNADLEHCGMVGRCFDQHDCKKGCGKMTQSELLAVSCEKKEYCSLAVLTIQKSHTYTNIECGARAATEYYQITPNATEGATIDGTTTATMKLTRTVSVFSTQPTAETAKGVSGAVGASTESDTSAETTSEATPEASEGSSEDSSSGSPTNTGAIIGGVIGGLVVVCSTALGSLYLLRRNRSQGTKPETTEQGTPPQEPLQTWAHRGPKQLAGWGPQEMQGSTQFGRDNAVELPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHZ0</accession>
    <name>C7ZHZ0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Expressed protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_102052</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698929">
        <property type="protein sequence ID" value="EEU36363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042076.1">
        <property type="nucleotide sequence ID" value="XM_003042030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHZ0"/>
    <dbReference type="STRING" id="660122.C7ZHZ0"/>
    <dbReference type="GeneID" id="9669077"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102052"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102052"/>
    <dbReference type="eggNOG" id="ENOG502SD7M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099566_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZHZ0"/>
    <dbReference type="OMA" id="AITWAND"/>
    <dbReference type="OrthoDB" id="1193027at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988866" evidence="10">
        <location>
            <begin position="24"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="11">
        <location>
            <begin position="22"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="94"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="147"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU36363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="244" mass="25598" checksum="822AF4709499B4F1" modified="2009-10-13" version="1">MKTSTSIRFAAAGVIGLASMAQAQSVCAINCFQSVITEHPPLDCTEENMYLCFCKRSNLQNWFAECIWDECDNQADAAISFGVDLCADYGITITPPTKPEEQPTTTKAEPQPTTQAEEEPESTQAEEEPESTQAQPQPTTEAEEQPESTQAEETQAEETQPAGETKATTAAAPAETTAETEAAAPKPTTVVVKPSQADNTTVVSPTNPPTVVNMGASNAASGILAAAGLAVAAFQLLPVNACKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZIJ7</accession>
    <name>C7ZIJ7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_87168</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698931">
        <property type="protein sequence ID" value="EEU36035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041748.1">
        <property type="nucleotide sequence ID" value="XM_003041702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZIJ7"/>
    <dbReference type="STRING" id="660122.C7ZIJ7"/>
    <dbReference type="GeneID" id="9674205"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87168"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87168"/>
    <dbReference type="eggNOG" id="ENOG502SMXZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_3_1_1"/>
    <dbReference type="InParanoid" id="C7ZIJ7"/>
    <dbReference type="OMA" id="IKISICA"/>
    <dbReference type="OrthoDB" id="3897607at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF15">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="38"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU36035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="325" mass="35536" checksum="F8C506A13A5AB4F5" modified="2009-10-13" version="1">MSSAAVEEWHAVEPQGLAAAILGVTITFTILCLLVVGLRVYLRLSTRNFGREDWLMCVGTTINMVHNGIVIWGCYTGIGTRDSKLNTPIMMEGAKAIVFWQIFYVTGSVFIKSSICAQLIRISTQRRYKIILYLLIAVSIITTLIAILAVLIRCKPVAASWNPTLGTCIDQSIIIALTASIATIIRMPYSSAYSNPKNLLCTLSFPYRSAPLSLTPVSDNVGNIILWTVVECGLGIIAGSMPMLRKLVKGLSKDESTGKSGTNDLNLVTIGRIKGKHHPIHDTDIQITVVAGGDPETARDDDSTKRMIRVTKMVNQTTSQGYREM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZIM3</accession>
    <name>C7ZIM3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_87194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698931">
        <property type="protein sequence ID" value="EEU36049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041762.1">
        <property type="nucleotide sequence ID" value="XM_003041716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZIM3"/>
    <dbReference type="GeneID" id="9674217"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87194"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87194"/>
    <dbReference type="HOGENOM" id="CLU_510981_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZIM3"/>
    <dbReference type="OrthoDB" id="5092514at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU36049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="533" mass="60549" checksum="035F6F83CC5D8DF8" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZIS4</accession>
    <name>C7ZIS4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_87245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698931">
        <property type="protein sequence ID" value="EEU36077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041790.1">
        <property type="nucleotide sequence ID" value="XM_003041744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZIS4"/>
    <dbReference type="STRING" id="660122.C7ZIS4"/>
    <dbReference type="GeneID" id="9674116"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87245"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87245"/>
    <dbReference type="eggNOG" id="ENOG502TFZM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_863539_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZIS4"/>
    <dbReference type="OMA" id="NDAPHLI"/>
    <dbReference type="OrthoDB" id="4725912at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU36077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="322" mass="34535" checksum="3B0C7DEE6C45F52E" modified="2009-10-13" version="1">MTDRSLGDHVKGFLSTLSSSHSNSNSPAPPYNGAYSQPPMQQPPYPDQQYGGQQYQQDWQSQNGPPSYYGQPPPQQWPPANQYPQQHNGPQQYGGQQQYNGPPQHGYQQGPPQGPYDQHPSHGFPPQQQQQQQQQQGYGQGPSGTPTSLHVRAAGDRVYYVVDSKTGQTVYTFNFGFKSSGAGPVHVMRGDNGPPCGTLTYHSFSSKVDMNLGNSFVKFKKDFPSNTGLGYLTWQKNGGGCFSSGGNLILESGGGVLATYRLEKGPGSQKRQGGGIEIQRPGLSQAQLDEIVISGVAELERLRLAAGSSSAGSSAGVIVAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKW2</accession>
    <name>C7ZKW2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vesicle-mediated transport protein Vid24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_69967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GID4/VID24 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698941">
        <property type="protein sequence ID" value="EEU35369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041082.1">
        <property type="nucleotide sequence ID" value="XM_003041036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKW2"/>
    <dbReference type="STRING" id="660122.C7ZKW2"/>
    <dbReference type="GeneID" id="9675535"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_69967"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_69967"/>
    <dbReference type="eggNOG" id="KOG4635">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028759_0_1_1"/>
    <dbReference type="InParanoid" id="C7ZKW2"/>
    <dbReference type="OMA" id="TMYDGRP"/>
    <dbReference type="OrthoDB" id="62at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018618">
        <property type="entry name" value="GID4/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534:SF3">
        <property type="entry name" value="GID COMPLEX SUBUNIT 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09783">
        <property type="entry name" value="Vac_ImportDeg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU35369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="42145" checksum="671904656E1D891A" modified="2009-10-13" version="1">MPTPSSNPPAEASSPRSYSFSTCPDDVQHQQRPSWQSREAVQDHNDDMGVQPTPDASPLTVDAPPAPEGPASDDTVMYEGRSSDDPSTRSSTMSPRPQSANTAVTSPISSGPSSDVTKGRDAEIGSQLSQETSNNTRQSSETETISRAPSSRRGSPNRELEWIDADAQEDELWAPSMGADFSCMRTIPSSPSSYLRSGSRFHGTQQSERQVYDVQVEIKHVDMRESFLCGYLRIQGLTEDHPTLTTYFEGEIIGSKYSFYTQHENWGANSKVDLSHWAKFAAFRPFQKQARKGPVMIRDAAQRETIFMRWKEHFLVPDHRVRTITGASFEGFYYICFNQVKGEVSGIYFHSKSEKFQQLELKHVPDRGCFAATEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLX8</accession>
    <name>C7ZLX8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RTA1 like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_78514</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698948">
        <property type="protein sequence ID" value="EEU34951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040664.1">
        <property type="nucleotide sequence ID" value="XM_003040618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLX8"/>
    <dbReference type="GeneID" id="9679086"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78514"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78514"/>
    <dbReference type="eggNOG" id="ENOG502QU4U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033465_6_1_1"/>
    <dbReference type="InParanoid" id="C7ZLX8"/>
    <dbReference type="OMA" id="NEAKFRF"/>
    <dbReference type="OrthoDB" id="4521223at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU34951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="35218" checksum="2DD91518BC0E6CCE" modified="2009-10-13" version="1">MSAPEGYIEGFVCTLDTCSVKDWGYVRYRPTVAGNAVFLAVMAILAIAQVYLGIRHKTRIFMITMCLGLVTETVGYISRVLLNGNPFSRDYFLWYLITLTIGPVFIAAAIYLTLGRLVVIHGEAISRIKPRTYTTFFLGCDIVSLVVQAVGGGIAASTPVTNQHMIDVGTNILVAGLSIQVACLFAFSACSLEFFWRVRKHPELHNPEFADLVHSKRFKMFLFALFGATACLFIRTVFRSVELSEGFAGKLANQEIEFMILDGVMVILACLVLTIWHPGYGFGKRWNEAGFRFRTSKARIDQEETPQTVSSGGSEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLX9</accession>
    <name>C7ZLX9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_78515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698948">
        <property type="protein sequence ID" value="EEU34974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040687.1">
        <property type="nucleotide sequence ID" value="XM_003040641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLX9"/>
    <dbReference type="STRING" id="660122.C7ZLX9"/>
    <dbReference type="GeneID" id="9679119"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78515"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78515"/>
    <dbReference type="eggNOG" id="KOG2741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_687084_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZLX9"/>
    <dbReference type="OMA" id="HARFINR"/>
    <dbReference type="OrthoDB" id="446809at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF1">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="13"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="3">
        <location>
            <begin position="144"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU34974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="379" mass="41554" checksum="9E2969BE3FC376C0" modified="2009-10-13" version="1">MTESNGTSSPWRIYLYGAGSIAWRHGVAAESLGPDVQLFAADPSKDAQEALLAKFPKATIFEDAEAMLASSEGQQHDIVVVAVPPWLHHAATLLAFKSNRHVLCEKPLATSETEMAEMLAASDSSGRIFGECSFRYLGNGALDRARQLIKTGGVGSVYHARFVNRQPRARAGIEYQPSSRWFLQKEKSGGGTIFDWGVYDLTMFFDVLRPVAATVTHAWLATPKTGADPPETAISVETHAGASLTLTLEDGSVIPFDWERASGFHGDPQVALNVDGTAGGLTWEWVPTFDYKDEVDQEKEGFKLVHYVDVDGKVHAREEKFPAFGWEDANHRPLLSFVDLIEGRESVALSRSRVEFNFSVVSAIYKSAAEGKPVHVQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZLY7</accession>
    <name>C7ZLY7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enoyl-CoA hydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_92338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698948">
        <property type="protein sequence ID" value="EEU34956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040669.1">
        <property type="nucleotide sequence ID" value="XM_003040623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZLY7"/>
    <dbReference type="STRING" id="660122.C7ZLY7"/>
    <dbReference type="GeneID" id="9679090"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_92338"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_92338"/>
    <dbReference type="eggNOG" id="KOG1680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_2_1"/>
    <dbReference type="InParanoid" id="C7ZLY7"/>
    <dbReference type="OMA" id="GWTETAH"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF4">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G01890)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="33307" checksum="9837C1DA4D51802C" modified="2009-10-13" version="1">MASSTSPDSYSSLSLKDISVSHVPADSPTATKVLVVALNRPNKYNAVTENLLNELETVYNLINTDERVRAVVLTGNGKAFCAGADLEVGFSGLLAHKKNPEAFNKFRDQGGRVALLIAKCIKPTIVAINGPAAGVGLTITLPATIRVGWSEAKVGLPFSRRGLTLESCSAFFLPRLVGLSNAIHLATTGSTYLASDPLVSGLFSKLLPTPQETASYAVKLAADIAENTSLASTKLMRDMMLYCPPTPEETHVLDSKIFLHSVGTKDNVEGIKSFMQKRKPEFSGTINPSEFPSWPWWDVAEKKEKNAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMA6</accession>
    <name>C7ZMA6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="4">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_55090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="4"/>
    <dbReference type="EMBL" id="GG698950">
        <property type="protein sequence ID" value="EEU34883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040596.1">
        <property type="nucleotide sequence ID" value="XM_003040550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMA6"/>
    <dbReference type="STRING" id="660122.C7ZMA6"/>
    <dbReference type="GeneID" id="9679005"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55090"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55090"/>
    <dbReference type="eggNOG" id="ENOG502RYJ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031468_2_0_1"/>
    <dbReference type="InParanoid" id="C7ZMA6"/>
    <dbReference type="OMA" id="THREIEY"/>
    <dbReference type="OrthoDB" id="3609at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF30">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="5">
        <location>
            <begin position="4"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="6">
        <location>
            <begin position="187"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU34883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="333" mass="36094" checksum="DD8A0D7F2A28FB75" modified="2009-10-13" version="1">MARVLIFGTGSIGTLYAYVLWRAGASVVCVCRSNYREAKENGFTIRSTIFGDHTFKPEIALSIDNAGASHNHHFDYVIVCTKAFPDSKPNPAELIAPAIESSPGATIILIQNGIGIEEPYAQLYPNNFIISAVTYSPSTQVSPVEIRHTESVRLCVGSFPAAKDDPRVAHFSELINLGGGRAETYPDIQIERWKKLIANATWNPICSLSRCRDVEFLSASPFAFDCAKDVMREIVAVGVAVLGPGALDGSAIDAQLERTANRAWPGVEPSMMSDMLSGKRMETMAIIGEVVRLARKHAVSTPRTETLYVLVSALDWAIQQKHPGSSGNLTKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMN5</accession>
    <name>C7ZMN5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oleate hydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_52774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698957">
        <property type="protein sequence ID" value="EEU34701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040414.1">
        <property type="nucleotide sequence ID" value="XM_003040368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMN5"/>
    <dbReference type="STRING" id="660122.C7ZMN5"/>
    <dbReference type="GeneID" id="9678837"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_52774"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_52774"/>
    <dbReference type="eggNOG" id="ENOG502QRWG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024043_2_0_1"/>
    <dbReference type="InParanoid" id="C7ZMN5"/>
    <dbReference type="OMA" id="REMEAHF"/>
    <dbReference type="OrthoDB" id="545169at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050151">
        <property type="term" value="F:oleate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010354">
        <property type="entry name" value="Oleate_hydratase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010584">
        <property type="entry name" value="PRK13977.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37417">
        <property type="entry name" value="67 KDA MYOSIN-CROSS-REACTIVE ANTIGEN FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G09970)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37417:SF3">
        <property type="entry name" value="MYOSIN-CROSSREACTIVE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06100">
        <property type="entry name" value="MCRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU34701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="585" mass="66602" checksum="598BCBFCE37131BD" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZN48</accession>
    <name>C7ZN48_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_88864</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698962">
        <property type="protein sequence ID" value="EEU34558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040271.1">
        <property type="nucleotide sequence ID" value="XM_003040225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZN48"/>
    <dbReference type="GeneID" id="9678707"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88864"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88864"/>
    <dbReference type="HOGENOM" id="CLU_717822_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZN48"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="250"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="344"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU34558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="385" mass="43368" checksum="1E7FE32190222894" modified="2009-10-13" version="1">MPNVVICQISKTSYPTLANISYLKDKFVDGKWHPEKFHPSNMTDSNIHRSVREIVEILLEHKVPLNVLWRENGYFRVAIDRFCQRGRPKLTDTVGLSVLWFVTQKFKNSQDTWRIEEDTTNYQDFDKIVGKKDKAGVINPGGKVLEPEMVMVTRQTMKSIMKDSPLPSSSLGNQSDAARGSQGNQVANNGEAVHASQQNSEREGEAQDDGDSQGDGDSLSTVSPQKSKRKRLESLGDDDESRPSQEVDEIDKLAQELGASDEALAEANKLLAERQKKQERLERVIASINEEISLAAVEAELLTWAVGANIITDPTSQASTPDGELRASRVENRRQDLGLYTNMLEFVEREEHGLLIQVEELEQERQVLEEERCEMTEALMTQLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNC9</accession>
    <name>C7ZNC9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_88710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698966">
        <property type="protein sequence ID" value="EEU34478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040191.1">
        <property type="nucleotide sequence ID" value="XM_003040145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNC9"/>
    <dbReference type="GeneID" id="9678008"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88710"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88710"/>
    <dbReference type="HOGENOM" id="CLU_1034746_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZNC9"/>
    <dbReference type="OrthoDB" id="4161428at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="269" mass="29848" checksum="DAD54718322F4868" modified="2009-10-13" version="1">MTIQGLMGKYPREFVPGRHPGRRLRAVDQSLETRPGPVEELDGLEACVGELENELGQLEEEISGTTDTNAKVKQLEDNTKSFRQILHHTQANDSQQRQVAVAEHVQAVFELLLPFKRTHATVKLPYSNWKEPRHHFPVTLGPGNLTDSVASLRCGQSPLPPQAIAPYTNKAKQAMLSATELYHESPLELSIPDSRTRVEFEQALDMLGKVSVGHPISARDAREMGPIQGPTDTFILCSSPEARDILRNGPPNLPMLIIDDESKQAAFNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNT2</accession>
    <name>C7ZNT2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_85531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039961.1">
        <property type="nucleotide sequence ID" value="XM_003039915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNT2"/>
    <dbReference type="STRING" id="660122.C7ZNT2"/>
    <dbReference type="GeneID" id="9677690"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85531"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85531"/>
    <dbReference type="eggNOG" id="ENOG502R41Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002639_7_1_1"/>
    <dbReference type="InParanoid" id="C7ZNT2"/>
    <dbReference type="OMA" id="IHRARIN"/>
    <dbReference type="OrthoDB" id="5125733at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="283"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="728" mass="82623" checksum="163693EC4D8E5AA9" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNY4</accession>
    <name>C7ZNY4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_50224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039901.1">
        <property type="nucleotide sequence ID" value="XM_003039855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNY4"/>
    <dbReference type="GeneID" id="9677622"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_50224"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_50224"/>
    <dbReference type="eggNOG" id="ENOG502SPW4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042072_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZNY4"/>
    <dbReference type="OMA" id="EWALARC"/>
    <dbReference type="OrthoDB" id="5216135at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU34188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="552" mass="62978" checksum="DBCC79FB2427F6B8" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZP52</accession>
    <name>C7ZP52_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidoligase enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_85598</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039798.1">
        <property type="nucleotide sequence ID" value="XM_003039752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZP52"/>
    <dbReference type="STRING" id="660122.C7ZP52"/>
    <dbReference type="GeneID" id="9677936"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85598"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85598"/>
    <dbReference type="eggNOG" id="ENOG502SUNA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071104_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZP52"/>
    <dbReference type="OMA" id="REREHRC"/>
    <dbReference type="OrthoDB" id="5291055at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022025">
        <property type="entry name" value="Amidoligase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847:SF1">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12224">
        <property type="entry name" value="Amidoligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU34085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="39735" checksum="AB2F9315A11C9CE5" modified="2009-10-13" version="1">MEDLFRSELRHDDWGDVHDVWSCTITNPEDYSFGVEIELVAIPKTVYDSNSNDFLNADVVYWRRRLADRMNSKKYLHAVTSRRPRDYDRWYIMNDASLRFQPRNYQVALEAVSPVMMQFQELKKQIDLFWEATTELFDIETNTSCGTHVHVAPRDHGYTLEELRRLAYAVATEEKFVLQILPQERIDNHYCRPCSFRSEELRLDLQEGEEDDIEHPSCYVAERLRGIRNESELIDYMQSNNRYVLWNLKNTQSQSGTVEFRGGRHMRGPVRTKRWIAFTVAFVNKAIECSGMYDRTVESDMDEWWQNIRSRAEEMRMHEFLPGSWQRMRDIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZP71</accession>
    <name>C7ZP71_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_27983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039808.1">
        <property type="nucleotide sequence ID" value="XM_003039762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZP71"/>
    <dbReference type="STRING" id="660122.C7ZP71"/>
    <dbReference type="GeneID" id="9677536"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_27983"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_27983"/>
    <dbReference type="eggNOG" id="ENOG502RYVR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084257_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZP71"/>
    <dbReference type="OMA" id="STDCGAD"/>
    <dbReference type="OrthoDB" id="15981at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3620.10">
        <property type="entry name" value="YdcF like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051599">
        <property type="entry name" value="Cell_Envelope_Assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30336:SF20">
        <property type="entry name" value="DUF218 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30336">
        <property type="entry name" value="INNER MEMBRANE PROTEIN, PROBABLE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU34095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="31035" checksum="FA3C1B7D4B2DD9CD" modified="2009-10-13" version="1" fragment="single">LFSSANLISRFLALEQIYSANELETYLDSLRNITESQPTDVVVLCASAILAIAEAVFEWAARYIQKTTPESNQEHPRRMVLVLCGGIGPSTRFVYDAVKANARYSCIFDSVEGKPEAHVLKIIAERFYGLDVGGSNLTPSPSDLENHGLTILMADRSINCGASPEETQKVLESHGIHSPSSITVVQDPAMSRRTVACFESVYSKCVQRPKIGSWPILAPESTAYGVKLDDGKGLWSMDRFLDRILGEMPVVRDSDDGYRRGSGSSRVDIPDEVEDAWTTVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZPC0</accession>
    <name>C7ZPC0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_85666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039828.1">
        <property type="nucleotide sequence ID" value="XM_003039782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZPC0"/>
    <dbReference type="GeneID" id="9677678"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85666"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85666"/>
    <dbReference type="HOGENOM" id="CLU_1315715_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZPC0"/>
    <dbReference type="OrthoDB" id="5104132at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU34115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="209" mass="23611" checksum="3A0EB7382EE31877" modified="2009-10-13" version="1">MHPHGACMWHRLIVCSVPSQLEKGTKDLMDTMAYIDMTINLNRRVQHVTRSASSSRYKPQYLSMEDQHCSTEIRVLPFKARKGLVAATTKLGIRLTTIVGSFKSNNDPLKAYDQSMNQQQTEIGCPAQNPNESLAQHRRHNTTHTDFLSWNAIVREFHSDVLKALRSVELDGGLVNTITERIPIKWVPGVNKEVLEEAQDAIMHVAPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZQF7</accession>
    <name>C7ZQF7_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_56140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698991">
        <property type="protein sequence ID" value="EEU33749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039462.1">
        <property type="nucleotide sequence ID" value="XM_003039416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZQF7"/>
    <dbReference type="GeneID" id="9666986"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_56140"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_56140"/>
    <dbReference type="HOGENOM" id="CLU_2711639_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZQF7"/>
    <dbReference type="OrthoDB" id="5396311at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU33749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="73" mass="8236" checksum="47B7FB845D370F6B" modified="2009-10-13" version="1" fragment="single">FIRYYHKARKIRPKSRNIIGGWKSSGLWPVSMAKSLMNPMASKLEERPVTPPEALTPSSEATESLFCTPRSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZR78</accession>
    <name>C7ZR78_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_89343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699040">
        <property type="protein sequence ID" value="EEU33480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039193.1">
        <property type="nucleotide sequence ID" value="XM_003039147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZR78"/>
    <dbReference type="GeneID" id="9666714"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89343"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89343"/>
    <dbReference type="HOGENOM" id="CLU_1163513_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZR78"/>
    <dbReference type="OrthoDB" id="5095609at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU33480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="210" mass="23232" checksum="DBCBC7C540407CDB" modified="2009-10-13" version="1">MGTLEAAKEVLKGSPFSLNLAKSKEKAIEDLKLEGLKALEALQDLPKQHSLLLLRGSIQLLLRHLQRQLDPAGLEDLWEEADTLIREAIIALVARSPTLPVREGGLGIPLHRDLAHELFLAAREASQPTLGLIRKPLAQPTLDQSQPNQGQPRLGKTAQQVLKEANKARLAGFLEDLPPSYRHARLENASYLGHITHKEAQKSSYRGPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZRE1</accession>
    <name>C7ZRE1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Azaphilone pigments biosynthesis cluster protein L N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_98466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG699065">
        <property type="protein sequence ID" value="EEU33417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039130.1">
        <property type="nucleotide sequence ID" value="XM_003039084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZRE1"/>
    <dbReference type="STRING" id="660122.C7ZRE1"/>
    <dbReference type="GeneID" id="9666652"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_98466"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98466"/>
    <dbReference type="eggNOG" id="ENOG502SICT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032923_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZRE1"/>
    <dbReference type="OMA" id="QCMNVVA"/>
    <dbReference type="OrthoDB" id="5068804at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="1">
        <location>
            <begin position="96"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU33417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="333" mass="36868" checksum="E2B4F07C61C1C010" modified="2009-10-13" version="1">MADGLSIASSVIALIAFAFKSSTVLYTTVRDFQSQDKNVRALKNELSDLRGVLESLANTVDNNSNVSFDALKLPLLRCGKTCEEYGALIARRMVSLITPDALEEYKDLIRDTSSDLQEHMTRLDERVRALVASEADGSVRDAPEWMAMVEEKQTQIEQLESASKEHPQFLQQPSAHKFIRSGLGIAKGSIQSLVSQLQTHENDIDKRMESMRSTVPLSEHEATQLAQLQETKESLRQCMSVVADAGETLTNERCNIFEDITMADSSYGISVSTVKDLVVARRLNLSGQARYLGGQISDESYQKTIDGLTHLDLESAKSYGKSDRKTSRGYGCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7YGX0</accession>
    <name>C7YGX0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_90059</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="domain">
        <text evidence="6">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053529.1">
        <property type="nucleotide sequence ID" value="XM_003053483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YGX0"/>
    <dbReference type="GeneID" id="9664326"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90059"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90059"/>
    <dbReference type="eggNOG" id="KOG0819">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025300_4_1_1"/>
    <dbReference type="InParanoid" id="C7YGX0"/>
    <dbReference type="OMA" id="VRGPLMQ"/>
    <dbReference type="OrthoDB" id="37886at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000002">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000005">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009117">
        <property type="entry name" value="ANX14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF102">
        <property type="entry name" value="ANNEXIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01813">
        <property type="entry name" value="ANNEXINFUNGI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0041">Annexin</keyword>
    <keyword evidence="3 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 6" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU47816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="445" mass="49063" checksum="DE99418E3E6940CB" modified="2009-10-13" version="1">MAPQGYGQQYPPPPPGQYPPPQQPYGGGYQQQQGGYPQQGGHQQPQGHYPPPQQPPYGGYQQPPPPQPYGAPPGQYGAPPPQHHQQPYGGHSPAPPAPYGAPPPGAPYGAPPQQYGAPPTQPTPPSPGYGPPQIIQWDANPDAQALRKAMKGFGTDEKALISILSNKDPLQIDTLRAAYERAHRRNLVSDIQSETSSWFEKALVQLARGPLLSDVHNLHEAMSGPGTKELVLNDILLGRSNADLQAIKSAYHHTFHDKLENVVKGDLSMKTERHFLLVLAANRAEDSAPVDPRQVDDDVMQIYKATEGKLGTDEILVCSIMSKRNDNQIRAIAHTYKQKFNKDLEKVIKSEFSGHMEDALLFQLRNATDKYMHAAKLLEDSMAGMGTKDHLLIARVIRFHWDRNTLANVKGAYQQRYGRSLGSRVKGETSGDYRRTMLAALGEPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C7YGZ3</accession>
    <name>C7YGZ3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="13">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">NECHADRAFT_105814</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054258.1">
        <property type="nucleotide sequence ID" value="XM_003054212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YGZ3"/>
    <dbReference type="FunCoup" id="C7YGZ3">
        <property type="interactions" value="852"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YGZ3"/>
    <dbReference type="GeneID" id="9664339"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_105814"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_105814"/>
    <dbReference type="eggNOG" id="KOG2431">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003818_3_0_1"/>
    <dbReference type="InParanoid" id="C7YGZ3"/>
    <dbReference type="OMA" id="AAFKHSW"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF55">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="591"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="606"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="479"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="567"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="373"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEU48545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="618" mass="70819" checksum="8D056226876C99CA" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7YI39</accession>
    <name>C7YI39_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_98907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053739.1">
        <property type="nucleotide sequence ID" value="XM_003053693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YI39"/>
    <dbReference type="FunCoup" id="C7YI39">
        <property type="interactions" value="519"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YI39"/>
    <dbReference type="GeneID" id="9664496"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_98907"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98907"/>
    <dbReference type="eggNOG" id="KOG3086">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038085_0_0_1"/>
    <dbReference type="InParanoid" id="C7YI39"/>
    <dbReference type="OMA" id="MHLPYIH"/>
    <dbReference type="OrthoDB" id="417112at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU48026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="324" mass="35704" checksum="0361329CB587A2B5" modified="2009-10-13" version="1">MVATRPAAKAGSWYKSNAKTLQAELLNNLAAVPESLDGASLPIPGARIIIAPHAGYEFSGPCAAWAYKTLDLSRAKRVFVLGPSHTYYLEGCAATTFDKYETPFGELTVDRALAKKFEDAASMDLMPQRNEVLEHSLEMHMPYLYLRCQQTFGSPDKFPKIVPVLVGSNNGPEEKEVGRALLPYLKDPENAFIISSDFCHWGHNFSYMVYSPTSSPGDLVKLRRQDRAPAGPPIHETIRAIDEAAMDGVKSGSHDAFLATLKQTKNTVCGRHPIGVMMAALELLGQEPQYQGKGRFQVIQYDRSNLVQEPDDMSVSYVSAYAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIA6</accession>
    <name>C7YIA6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multiple RNA-binding domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_30669</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-rRNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM MRD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053775.1">
        <property type="nucleotide sequence ID" value="XM_003053729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIA6"/>
    <dbReference type="FunCoup" id="C7YIA6">
        <property type="interactions" value="1126"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YIA6"/>
    <dbReference type="GeneID" id="9676406"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_30669"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_30669"/>
    <dbReference type="eggNOG" id="KOG0110">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008479_0_0_1"/>
    <dbReference type="InParanoid" id="C7YIA6"/>
    <dbReference type="OMA" id="FNNTCIQ"/>
    <dbReference type="OrthoDB" id="439639at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034462">
        <property type="term" value="P:small-subunit processome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12568">
        <property type="entry name" value="RRM3_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12320">
        <property type="entry name" value="RRM6_RBM19_RRM5_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000247">
        <property type="entry name" value="Multiple RNA-binding domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000452">
        <property type="entry name" value="Multiple RNA-binding domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034482">
        <property type="entry name" value="Mrd1_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="4"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="310"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="492"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="609"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="714"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="80"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="157"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="243"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="690"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="107"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="692"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU48062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="838" mass="91878" checksum="60BA386315CF44FB" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIF1</accession>
    <name>C7YIF1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_31115</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054505.1">
        <property type="nucleotide sequence ID" value="XM_003054459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIF1"/>
    <dbReference type="STRING" id="660122.C7YIF1"/>
    <dbReference type="GeneID" id="9676426"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_31115"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_31115"/>
    <dbReference type="eggNOG" id="KOG2431">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003818_0_0_1"/>
    <dbReference type="InParanoid" id="C7YIF1"/>
    <dbReference type="OMA" id="TEHAWTM"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000037">
        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF89">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="506"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="594"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="399"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU48792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="604" mass="68202" checksum="C88FC106E4447668" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIM3</accession>
    <name>C7YIM3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nitrogen permease regulator 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_90396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054546.1">
        <property type="nucleotide sequence ID" value="XM_003054500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIM3"/>
    <dbReference type="FunCoup" id="C7YIM3">
        <property type="interactions" value="200"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YIM3"/>
    <dbReference type="GeneID" id="9664663"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90396"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90396"/>
    <dbReference type="eggNOG" id="KOG3789">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014995_3_1_1"/>
    <dbReference type="InParanoid" id="C7YIM3"/>
    <dbReference type="OMA" id="IVMHKPD"/>
    <dbReference type="OrthoDB" id="338854at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009348">
        <property type="entry name" value="NPR2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991:SF10">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991">
        <property type="entry name" value="NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06218">
        <property type="entry name" value="NPR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU48833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="46628" checksum="60586E070F5C4E96" modified="2009-10-13" version="1">MIQGIFYARFFPQEGPKIVAQSPAGCITPVDSSTKAPLIDFDVLHEYIIPRQAFCNRYLTINTPDGKYTVLGHPVVIPHTKYLRNEFIFNFGLVLDADVDHVPYERVVRGLASTFSEMEKQNEYLSQNAETKGPGRRPIDSLLEIVKEDLDNYGECMIPVDEANTINMKLFPHHVDPPRVRGWHVPVPKTKFADIVDPTWDLTLQKVISHIDGVSDVRRIAHAASVSLELAKTALRHLLYYDTILLLDMFFFSACYAPRPGIHDFIRNVDGMVDECAAYVSHGRGRVSNYHLIKLMSTFAPGRTVMEWLKGHQDAGFEVLRFVDVRRLVQFGVIKGCLYRVHKFVVSKQYLAALASGQSRPIPGGDPLQKYTDGCHHFDQIITEQNLTDSEIMEKLKKLPVPKGDLVVFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIY8</accession>
    <name>C7YIY8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Squalene synthase</fullName>
            <shortName evidence="15">SQS</shortName>
            <shortName evidence="15">SS</shortName>
            <ecNumber evidence="4 15">2.5.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">NECHADRAFT_75492</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 (2E,6E)-farnesyl diphosphate + NADH + H(+) = squalene + 2 diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:32299"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 (2E,6E)-farnesyl diphosphate + NADPH + H(+) = squalene + 2 diphosphate + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:32295"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.21" evidence="4 15"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053888.1">
        <property type="nucleotide sequence ID" value="XM_003053842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIY8"/>
    <dbReference type="FunCoup" id="C7YIY8">
        <property type="interactions" value="349"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YIY8"/>
    <dbReference type="GeneID" id="9676525"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75492"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75492"/>
    <dbReference type="eggNOG" id="KOG1459">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031981_2_1_1"/>
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        <property type="reaction ID" value="UER00751"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="entry name" value="Farnesyl-diphosphate farnesyltransferase 1"/>
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    </dbReference>
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        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
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        <property type="entry name" value="Squal_synth-like"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
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        <property type="entry name" value="squal_synth"/>
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    </dbReference>
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        <property type="entry name" value="FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626:SF2">
        <property type="entry name" value="SQUALENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006251"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012373"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEU48175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="462" mass="53375" checksum="F0692C9044FBE148" modified="2009-10-13" version="1">MGALYYLFHPNQLRSIIQWKVWHDPVHKRDPSTESPELQECFRYLNMTSRSFAAVIQELNHELLVPITLFYLVLRGLDTIEDDMTLPLDKKVPLLREFHNTMEQDGWQFHESQEKDKELLEHFDVVITELKKIKPQYYEIIKDMTIKMGNGMADYAQNTEMIENGVQTIDEYELYCHYVAGLVGEGLTRLFVASELANPKLAERPSLTESMGQFLQKTNIIRDIHEDWEDGRRWYPKEIWSKHVDKWEDLFDPKQRTKAIECVSEMVLDALKHSEECLFYMAGIKDQSVFNFVAIPQGMAIATLELVFRNPNVLERNVKITKGDACQIMFESTQNLVTVCDVFKRYARRIQAKNDPRDPSYLAISAQCAKIEQFIETLFPRQDPKKLALENNQRQNKEPTMDPGEAVVLFGVVIASLLCISGLMIGTAWFFGARFDNIFKEASVFLPGGEKATPLVTGRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJ66</accession>
    <name>C7YJ66_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription initiation factor TFIID, subunit TAF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">HAF2101</name>
        <name evidence="5" type="ORF">NECHADRAFT_105857</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053927.1">
        <property type="nucleotide sequence ID" value="XM_003053881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJ66"/>
    <dbReference type="FunCoup" id="C7YJ66">
        <property type="interactions" value="399"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YJ66"/>
    <dbReference type="GeneID" id="9663709"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_105857"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_105857"/>
    <dbReference type="eggNOG" id="KOG0008">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000572_1_1_1"/>
    <dbReference type="InParanoid" id="C7YJ66"/>
    <dbReference type="OMA" id="RFINYYR"/>
    <dbReference type="OrthoDB" id="5752at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 1 histone acetyltransferase" evidence="4">
        <location>
            <begin position="418"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="26"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="770"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="931"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1024"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1092"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="770"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="931"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1024"/>
            <end position="1040"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU48214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1114" mass="124800" checksum="ABD2AFC971BDED01" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7YJF7</accession>
    <name>C7YJF7_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_75662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053980.1">
        <property type="nucleotide sequence ID" value="XM_003053934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YJF7"/>
    <dbReference type="GeneID" id="9663837"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75662"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75662"/>
    <dbReference type="eggNOG" id="ENOG502RMW8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1012150_0_0_1"/>
    <dbReference type="InParanoid" id="C7YJF7"/>
    <dbReference type="OMA" id="RRQVCDK"/>
    <dbReference type="OrthoDB" id="5072071at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU48267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="296" mass="32092" checksum="3EC9AAC1D74C440C" modified="2009-10-13" version="1">MCHEVITIALCAPTKAPSLSFTCGKLHMIAQQRHVCDRARGSCVCFFGTCGTVEKNASTSGIDLSAIEKIRCAECTTREDNVGDRRDAKQIIESPLLQRIPIEPTDDFVNKKHSAMLHELWGGARTCPFHLQPDRPRQPSASTVNVQTKRFDERPVTPQTNDESVTKSHSMSRDSVDKGWTSQAATNNSSKSKLSRKSSASPTGIASVDSAVGLGSSRWAPKNLEEAAARSVKNQSPPTQKRPSPLQKQSSPPSQKRIVPAAAPVFVADPGNASKVRHATKKMANMKAFLSGTPMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7YK92</accession>
    <name>C7YK92_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_31482</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054120.1">
        <property type="nucleotide sequence ID" value="XM_003054074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YK92"/>
    <dbReference type="GeneID" id="9664126"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_31482"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_31482"/>
    <dbReference type="eggNOG" id="KOG1812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008347_0_0_1"/>
    <dbReference type="InParanoid" id="C7YK92"/>
    <dbReference type="OMA" id="CCLNQIP"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="212"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="436"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="507"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU48407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="704" mass="81798" checksum="3A561CEF9C68DBE9" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7YL54</accession>
    <name>C7YL54_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Neutral protease 2</fullName>
            <ecNumber evidence="15">3.4.24.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Deuterolysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">NECHADRAFT_36693</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Secreted metalloproteinase that allows assimilation of proteinaceous substrates. Shows high activities on basic nuclear substrates such as histone and protamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Preferential cleavage of bonds with hydrophobic residues in P1'. Also 3-Asn-|-Gln-4 and 8-Gly-|-Ser-9 bonds in insulin B chain.</text>
            <dbReference type="EC" id="3.4.24.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M35 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.39" evidence="15"/>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052442.1">
        <property type="nucleotide sequence ID" value="XM_003052396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YL54"/>
    <dbReference type="GeneID" id="9663603"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_36693"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_36693"/>
    <dbReference type="eggNOG" id="ENOG502SGF5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039313_0_0_1"/>
    <dbReference type="InParanoid" id="C7YL54"/>
    <dbReference type="OMA" id="ATQVYQN"/>
    <dbReference type="OrthoDB" id="412874at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11008">
        <property type="entry name" value="M35_deuterolysin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050414">
        <property type="entry name" value="Fungal_M35_metalloproteases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029463">
        <property type="entry name" value="Lys_MEP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001384">
        <property type="entry name" value="Peptidase_M35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016:SF2">
        <property type="entry name" value="NEUTRAL PROTEASE 2 HOMOLOG SNOG_02177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02102">
        <property type="entry name" value="Peptidase_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00768">
        <property type="entry name" value="DEUTEROLYSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01351">
        <property type="entry name" value="Aspzincin_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="10 14 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012452169" description="Neutral protease 2" evidence="16">
        <location>
            <begin position="16"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Lysine-specific metallo-endopeptidase" evidence="17">
        <location>
            <begin position="202"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601384-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601384-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEU46729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="349" mass="37529" checksum="04F62EE757197DEE" modified="2009-10-13" version="1">MKLLAGLALASMAVAAPLVEKRAPTPLNVSLEMQGNSKIKAVITNNGKSNLKLLKSGTFLDSTAVEKAQVYSGEKNIPFDGVRVALDTSRLEETAFQRIPSGESIEVDFDIAEFHDLSAGGKFNILAEGALSFAQDDSTELIGSVPFYSNRIEAEVDGPQAFSVRTAFHHKRTQVQSDCSGDKLAITQNALSRCSSMASKAQQAAASGSGDKMKEYFKSDSYETRQTVADVFGRIASECGSTNSGDSRYYCSDVYGACQSGVLAYTVPGASYMAYCDLYFQQLPATTTSCHGQDQAQTNVHEMTHLNQIKGTSDYGGYGYNFLQSLSADQNINHADTYALFANAIELGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLT0</accession>
    <name>C7YLT0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_77643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052541.1">
        <property type="nucleotide sequence ID" value="XM_003052495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YLT0"/>
    <dbReference type="GeneID" id="9663805"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77643"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77643"/>
    <dbReference type="HOGENOM" id="CLU_950250_0_0_1"/>
    <dbReference type="InParanoid" id="C7YLT0"/>
    <dbReference type="OrthoDB" id="5101096at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU46828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="293" mass="32570" checksum="F4FEDFE8392887F5" modified="2009-10-13" version="1">MEQENIPKRKHNMKDLYRELSKRYNTMPIYITDPAIFNYQCATAMSEASGSEEFIEMVADIKESNMAEAVTYAQNMFAEQDDRFPGLTCLVSMDSILDLAGVPVYENLFQEDRPTMNELDPEWLSDIKDYLPERSECIGGRPPNYLSSEESDSEDDAQSDYSESSVDEVPVKPRKRIRRGASPSTTGSSSTSASTEGRTLRNGKRTRTPDDADTVVDEAPKNKRRRKGKTSSSNSSNSNNSSSNSSSSHSASLPSVTESAPDPDAEYDLLDDGDFPLLRRSGRLNRIAGRRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLU5</accession>
    <name>C7YLU5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isovaleryl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_103716</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052548.1">
        <property type="nucleotide sequence ID" value="XM_003052502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YLU5"/>
    <dbReference type="STRING" id="660122.C7YLU5"/>
    <dbReference type="GeneID" id="9663813"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_103716"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_103716"/>
    <dbReference type="eggNOG" id="KOG0141">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_1_1"/>
    <dbReference type="InParanoid" id="C7YLU5"/>
    <dbReference type="OMA" id="CFITNSG"/>
    <dbReference type="OrthoDB" id="9988775at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008470">
        <property type="term" value="F:3-methylbutanoyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000021">
        <property type="entry name" value="Isovaleryl-CoA dehydrogenase IvdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000003">
        <property type="entry name" value="isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000004">
        <property type="entry name" value="Isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF18">
        <property type="entry name" value="ISOVALERYL-COENZYME A DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="8">
        <location>
            <begin position="47"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="7">
        <location>
            <begin position="163"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="6">
        <location>
            <begin position="270"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU46835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="46212" checksum="2CE594E923E57258" modified="2009-10-13" version="1">MASVRTFRSLARPVAARQWRPAVTLPAIQSRLHSSKHPKGFEAPSKEELDELRDRVQEFTRREITEEVAAKTDKTNAFPAEMWQKLGEAGFLGITADEDVGGLAMGYQAHIIVMEELSRASGSIGLSYAAHSQLCVNQLQLNGSPEQKQKYLPGLIAGTSVGALAMSESGAGSDVVSMRTTAKAVDGGYVLNGSKMWITNGPDADVIVVYAKTEPDKASKGITAFLVDTKTEGFSCARKLDKMGMRGSNTGELMFDNVFVPTENILGKINGGVRVLMEGLDLERLVLSAGPLGIMQAALDVALPFTHQRKQFGQPIAHNQFLQGKLADMYTKLQASRAYTYMTAKAVDENGLIRTQDCAGAILYAAERATECTLDCIQLLGGMGYVEEMPASRLLRDAKLYEIGAGTSEIRRMVIGRAFNKEYAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7YM44</accession>
    <name>C7YM44_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">F-actin-capping protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_99630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the F-actin-capping protein alpha subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052592.1">
        <property type="nucleotide sequence ID" value="XM_003052546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YM44"/>
    <dbReference type="FunCoup" id="C7YM44">
        <property type="interactions" value="814"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YM44"/>
    <dbReference type="GeneID" id="9671124"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_99630"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_99630"/>
    <dbReference type="eggNOG" id="KOG0836">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045161_0_0_1"/>
    <dbReference type="InParanoid" id="C7YM44"/>
    <dbReference type="OMA" id="QEHFPNA"/>
    <dbReference type="OrthoDB" id="340550at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.60:FF:000004">
        <property type="entry name" value="F-actin-capping protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000003">
        <property type="entry name" value="F-actin-capping protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.60">
        <property type="entry name" value="F-actin capping protein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002189">
        <property type="entry name" value="CapZ_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042489">
        <property type="entry name" value="CapZ_alpha_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017865">
        <property type="entry name" value="F-actin_cap_asu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01267">
        <property type="entry name" value="F-actin_cap_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00191">
        <property type="entry name" value="FACTINCAPA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00748">
        <property type="entry name" value="F_ACTIN_CAPPING_A_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00749">
        <property type="entry name" value="F_ACTIN_CAPPING_A_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0117">Actin capping</keyword>
    <keyword evidence="6 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU46879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="272" mass="29618" checksum="8432D8C18B3668AB" modified="2009-10-13" version="1">MSEIETVSSFVEGAPPGELADVVADIKALAISSPDIISDLAPAFEKYNEEQFVTVKLPGSSQPVIISSHNSLGDGRYYDVESSSSFAFNHATQKASAVQSHVLEGPQTDLVKSTLKSLSAYVSEHFPNAAYGVYPIQSDSQIAVIIVGNKYSPNNFWNGRWRSLYIFDPSSGTLEGSIKVDVHYYEDGNVRLLTNKPVSGSIPSGSGAGVIKEISSTERKYQEELNKGFVSLSEGAFKGLRRQLPVTRQKIEWDRVTSYRLGQDIGGGSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C7YMR6</accession>
    <name>C7YMR6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_67563</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052712.1">
        <property type="nucleotide sequence ID" value="XM_003052666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YMR6"/>
    <dbReference type="FunCoup" id="C7YMR6">
        <property type="interactions" value="150"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YMR6"/>
    <dbReference type="GeneID" id="9671244"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_67563"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_67563"/>
    <dbReference type="eggNOG" id="KOG1450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010730_3_0_1"/>
    <dbReference type="InParanoid" id="C7YMR6"/>
    <dbReference type="OMA" id="DSGWQAR"/>
    <dbReference type="OrthoDB" id="437889at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07652">
        <property type="entry name" value="F-BAR_Rgd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000063">
        <property type="entry name" value="Rho GTPase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF136">
        <property type="entry name" value="RHO GTPASE ACTIVATOR (RGD1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="5">
        <location>
            <begin position="69"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="560"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="360"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="518"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="534"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU46999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="756" mass="81311" checksum="B4829D38DFF7D91C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7YMV9</accession>
    <name>C7YMV9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_78015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053228.1">
        <property type="nucleotide sequence ID" value="XM_003053182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YMV9"/>
    <dbReference type="STRING" id="660122.C7YMV9"/>
    <dbReference type="GeneID" id="9664219"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78015"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78015"/>
    <dbReference type="eggNOG" id="ENOG502SHG8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_138_11_1"/>
    <dbReference type="InParanoid" id="C7YMV9"/>
    <dbReference type="OMA" id="FWDMEDS"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF12">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="28"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU47515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="537" mass="61482" checksum="B9B0E67DA49DBB7D" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNS5</accession>
    <name>C7YNS5_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Expressed protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_100227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052339.1">
        <property type="nucleotide sequence ID" value="XM_003052293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNS5"/>
    <dbReference type="STRING" id="660122.C7YNS5"/>
    <dbReference type="GeneID" id="9672960"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100227"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100227"/>
    <dbReference type="eggNOG" id="ENOG502S9SW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1142669_0_0_1"/>
    <dbReference type="InParanoid" id="C7YNS5"/>
    <dbReference type="OMA" id="NTKRDND"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU46626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="294" mass="30867" checksum="BEE0CFBEEFDE298A" modified="2009-10-13" version="1">MSYGGNDNDSYGSSNRNESSYGSGNNDSYGSSRRDNDNDNDSYGSSNRRNESSSYGSGNNDSYGSSGRDNTSSSYGGGNDTYGSSRRDDDDDNKKSSYGSSRDNDDSYGTKSSSGGYGSSGRDNDNSYGSSNRDENKSSSYGSSGNTYGSSGRDNDDSYGSSRKDKDDNDSYGSSGNTYGSSGRDNDDSYGSKSSSGGYGSSNKDNDSYGSSGNTYGSSGRDNDDSYGSKTSSGGYGSSNKNESDSYGTSSGGYGSSKRNDDDESNTFVDKIKDKAGDFIGNKIKGNKNNDDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPC8</accession>
    <name>C7YPC8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_92490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051989.1">
        <property type="nucleotide sequence ID" value="XM_003051943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YPC8"/>
    <dbReference type="GeneID" id="9673142"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_92490"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_92490"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006909_8_1_1"/>
    <dbReference type="InParanoid" id="C7YPC8"/>
    <dbReference type="OMA" id="CTGYKND"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU46276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="62845" checksum="D9BBCCDED62644BD" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPK9</accession>
    <name>C7YPK9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kish</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_102531</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in the early part of the secretory pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Golgi apparatus membrane</location>
            <topology evidence="2 9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the KISH family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052027.1">
        <property type="nucleotide sequence ID" value="XM_003051981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YPK9"/>
    <dbReference type="FunCoup" id="C7YPK9">
        <property type="interactions" value="203"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YPK9"/>
    <dbReference type="GeneID" id="9673255"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102531"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102531"/>
    <dbReference type="eggNOG" id="KOG3808">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152663_1_0_1"/>
    <dbReference type="InParanoid" id="C7YPK9"/>
    <dbReference type="OMA" id="KVGFQGT"/>
    <dbReference type="OrthoDB" id="10034655at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051523">
        <property type="entry name" value="KISH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009653">
        <property type="entry name" value="Ksh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13229">
        <property type="entry name" value="PROTEIN KISH-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06842">
        <property type="entry name" value="DUF1242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005125795" description="Protein kish" evidence="9">
        <location>
            <begin position="23"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU910717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU46314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="71" mass="8044" checksum="3DDAD5492A58779D" modified="2009-10-13" version="1">MSALFNFQSLLLVLLLLICTSAYVHHFTPSIMDRNKNGFMGIFWKCARIGERLSPYISICCVLMACSILLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPR3</accession>
    <name>C7YPR3_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_59951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052051.1">
        <property type="nucleotide sequence ID" value="XM_003052005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YPR3"/>
    <dbReference type="STRING" id="660122.C7YPR3"/>
    <dbReference type="GeneID" id="9673279"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_59951"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_59951"/>
    <dbReference type="eggNOG" id="ENOG502QTJE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050424_0_1_1"/>
    <dbReference type="InParanoid" id="C7YPR3"/>
    <dbReference type="OMA" id="VWAFWSS"/>
    <dbReference type="OrthoDB" id="5582162at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022057">
        <property type="entry name" value="Chs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329:SF1">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12271">
        <property type="entry name" value="Chs7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU46338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="297" mass="32525" checksum="2C084B1A19075979" modified="2009-10-13" version="1">MGSTEFGNFHDFCRDSTLPVCNLLSNPAHDQNSASWGGCELKGIPLSGGRHLGNLGSILLAAIAIAAASFLVLRSERKRAAVGRREMQLFLIGYIIISICEIFSVGEFPLNKTARIVFSSVHIGMITATTWVLFLNAVVGYQIIDDGTPISVILFVVSAAALLIGSGYIALDTGLSWTGFWDDSYDAPNRNIAIYVLYQLFPLVCLVAYFVLEAILVIRILRELRPLLYLVGAALLFAIGQVFNYAVSKYICDGTSGKIDGSLFQTLFTLLAVVMLWVFWSSITEDDWPMPVTSTYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQ90</accession>
    <name>C7YQ90_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_104091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU45980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051693.1">
        <property type="nucleotide sequence ID" value="XM_003051647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQ90"/>
    <dbReference type="GeneID" id="9673446"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_104091"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_104091"/>
    <dbReference type="eggNOG" id="ENOG502QS3B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003963_1_0_1"/>
    <dbReference type="InParanoid" id="C7YQ90"/>
    <dbReference type="OMA" id="NPYPEYH"/>
    <dbReference type="OrthoDB" id="2419400at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000028">
        <property type="entry name" value="WW domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF2">
        <property type="entry name" value="WW DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G06520)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="463"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU45980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1199" mass="130509" checksum="A3629F995D6C0B90" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQR0</accession>
    <name>C7YQR0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">PUA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_92807</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051778.1">
        <property type="nucleotide sequence ID" value="XM_003051732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQR0"/>
    <dbReference type="FunCoup" id="C7YQR0">
        <property type="interactions" value="500"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YQR0"/>
    <dbReference type="GeneID" id="9673606"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_92807"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_92807"/>
    <dbReference type="eggNOG" id="KOG1154">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025400_1_1_1"/>
    <dbReference type="InParanoid" id="C7YQR0"/>
    <dbReference type="OMA" id="NLAFPPH"/>
    <dbReference type="OrthoDB" id="409889at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000020">
        <property type="entry name" value="Glutamate 5-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654:SF3">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="8">
        <location>
            <begin position="9"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="9">
        <location>
            <begin position="317"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU46065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="42854" checksum="1134818FFDECAF1F" modified="2009-10-13" version="1">MRGNGKSLTIVIKLGTSSIVDEKTHEPLLPILTLIVDTAVKLRKDGHRVVIVSSGAIGVGLRRMDVEKRPKHLAQLQALAAIGQCRLMSLWDSLFTHLRQPIAQILLTRNDIADRTRYFNAQNTFNALLEQGVIPIVNENDTLAVSEIKFGDNDTLSAITAAMIHADMLFLMTDVDCLYDKNPRTNPDAKPIEVVEDISALQADVSSAGSALGTGGMSTKIIAARLGTSAGVTTIITRSSNPGNVLNIVRYLQPQQKGHSSPSADEGTSHLTRSASALSLSSSADLTSPPLHTRFVPADDPIRDRHFWLLHTPYPHGTLYIDSGAYKALLGKAGLLPVGVVDVEGNFAQQEVVRLVVVKRRTTLGPDGKLWDGIPEEIGPSMSPTGNMLASLEETADP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQU5</accession>
    <name>C7YQU5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Store-operated calcium entry-associated regulatory factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Transmembrane protein 66</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">NECHADRAFT_79229</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SARAF family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051791.1">
        <property type="nucleotide sequence ID" value="XM_003051745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQU5"/>
    <dbReference type="STRING" id="660122.C7YQU5"/>
    <dbReference type="GeneID" id="9673703"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79229"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79229"/>
    <dbReference type="eggNOG" id="ENOG502QT6Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046802_1_0_1"/>
    <dbReference type="InParanoid" id="C7YQU5"/>
    <dbReference type="OMA" id="WILKGSC"/>
    <dbReference type="OrthoDB" id="20303at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001256">
        <property type="term" value="P:regulation of store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009567">
        <property type="entry name" value="SARAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929:SF0">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06682">
        <property type="entry name" value="SARAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988586" description="Store-operated calcium entry-associated regulatory factor" evidence="16">
        <location>
            <begin position="19"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="185"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="256"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEU46078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="304" mass="32427" checksum="260942C4BB7FC5F3" modified="2009-10-13" version="1">MIPSLFALCLGLPALTLAARQPKDAIKLSDVKSLTLRGKGAMTSHRRVSAIPQLRCASRGAICDLYEIDVMRCTNQGSSWGDEDIEWSCTASLPEELKLGSTDVICEGYAYPDDPYVLKGSCGVEYQLALTSKGERRYPDIANGGWFNDGRGGIDWGALVFTIIFVSILGWIIYSACCVAQRNNANNNRPRRRPDGWGGPGGWGPGWGPGGDDPPPPYPGTKPQNTDSWRPGFWSGAAGGAAAGYWAGSRNSNNNNNCNHDSNSNYGSIGRGGGGWHWGGSGSSSGSNNSNRHESTGFGSTSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C7YR99</accession>
    <name>C7YR99_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">FACT complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">GTC2101</name>
        <name evidence="17" type="ORF">NECHADRAFT_40731</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the FACT complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M24 family. SPT16 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050753.1">
        <property type="nucleotide sequence ID" value="XM_003050707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YR99"/>
    <dbReference type="FunCoup" id="C7YR99">
        <property type="interactions" value="1315"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YR99"/>
    <dbReference type="GeneID" id="9667829"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_40731"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_40731"/>
    <dbReference type="eggNOG" id="KOG1189">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004627_1_0_1"/>
    <dbReference type="InParanoid" id="C7YR99"/>
    <dbReference type="OMA" id="YHINTIP"/>
    <dbReference type="OrthoDB" id="10251642at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01091">
        <property type="entry name" value="CDC68-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000002">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.210:FF:000001">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000017">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000006">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000005">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.210">
        <property type="entry name" value="FACT complex subunit Spt16p/Cdc68p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029148">
        <property type="entry name" value="FACT-SPT16_Nlobe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056595">
        <property type="entry name" value="Fact-SPT16_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048969">
        <property type="entry name" value="FACT_SPT16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013953">
        <property type="entry name" value="FACT_SPT16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040258">
        <property type="entry name" value="Spt16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033825">
        <property type="entry name" value="Spt16_M24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980">
        <property type="entry name" value="CDC68 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980:SF15">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14826">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24824">
        <property type="entry name" value="PH_SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08644">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21091">
        <property type="entry name" value="SPT16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01285">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01286">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FACT complex subunit SPT16 N-terminal lobe" evidence="14">
        <location>
            <begin position="6"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="FACT complex subunit SPT16 middle" evidence="15">
        <location>
            <begin position="548"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="16">
        <location>
            <begin position="823"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="480"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="944"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="627"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="945"/>
            <end position="1007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEU45040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1034" mass="117954" checksum="1076326CB06359B8" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRC2</accession>
    <name>C7YRC2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcriptional coactivator HFI1/ADA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_93546</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051144.1">
        <property type="nucleotide sequence ID" value="XM_003051098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YRC2"/>
    <dbReference type="FunCoup" id="C7YRC2">
        <property type="interactions" value="1086"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YRC2"/>
    <dbReference type="GeneID" id="9667839"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_93546"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_93546"/>
    <dbReference type="eggNOG" id="ENOG502RX84">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038277_1_0_1"/>
    <dbReference type="InParanoid" id="C7YRC2"/>
    <dbReference type="OMA" id="EMAFTRG"/>
    <dbReference type="OrthoDB" id="10264870at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024738">
        <property type="entry name" value="Hfi1/Tada1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12767">
        <property type="entry name" value="SAGA-Tad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU45431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="48907" checksum="DFB907CAE12E56D7" modified="2009-10-13" version="1">MPDIDPAALSRPSVSLSTPILSNKTLAGSGAGAPKIAKSSQIIPARIDLEAPYAALKAAIGNEQWSIYKASTSEFLTGRLNQVEYSERIDPILAGPGDKEHLHNNLIAAIYGNVTREMPDQGLAPWVSANDKPAATTGSKPVSGDAAERRLKGDVMQLPARDRRRIKDLVHNDVCASLPASSQPLTCVSGILTRPSMVMDATPSAGVINNMNFDLEIRKRYAQPLAVESGEFPDIGMISGRMLPFCYEAGLVSGHAGDAPQFMSVAVDTFIKEVLTQVFSRTRSNGPGDSGSAGFGVGTTWIQTQKYKRQLEYEEDAAMRGEISRDKSGLLPIESKSASERGPLGMADLRLSLEMADTGMAQFPVLMTQVLYGYREGELENWDDYTWIHDQGPEGYLEENHVAGINGGRVFELPNGHPDAMDIDTETWWEGAENQDMDMLDAVLDSCLAVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRC9</accession>
    <name>C7YRC9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phospholipase D1</fullName>
            <ecNumber evidence="3">3.1.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Choline phosphatase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Phosphatidylcholine-hydrolyzing phospholipase D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_80347</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phospholipase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="3"/>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050770.1">
        <property type="nucleotide sequence ID" value="XM_003050724.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="C7YRC9">
        <property type="interactions" value="131"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YRC9"/>
    <dbReference type="GeneID" id="9667842"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_80347"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_80347"/>
    <dbReference type="eggNOG" id="KOG1329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000690_0_1_1"/>
    <dbReference type="InParanoid" id="C7YRC9"/>
    <dbReference type="OMA" id="DSLWTKH"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01254">
        <property type="entry name" value="PH_PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000011">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF76">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="12">
        <location>
            <begin position="911"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="12">
        <location>
            <begin position="1215"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="499"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1318"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1419"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1576"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1651"/>
            <end position="1764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="542"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1344"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1356"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1576"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1652"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1671"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1707"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1728"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1751"/>
            <end position="1763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU45057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1818" mass="205071" checksum="B7E8EFA15F29D3FF" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRY9</accession>
    <name>C7YRY9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor TFIIIC triple barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_80556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050866.1">
        <property type="nucleotide sequence ID" value="XM_003050820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YRY9"/>
    <dbReference type="GeneID" id="9668032"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_80556"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_80556"/>
    <dbReference type="eggNOG" id="ENOG502SV1F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047596_0_0_1"/>
    <dbReference type="InParanoid" id="C7YRY9"/>
    <dbReference type="OMA" id="FEGSWAE"/>
    <dbReference type="OrthoDB" id="1877767at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019481">
        <property type="entry name" value="TFIIIC_triple_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711:SF1">
        <property type="entry name" value="ECTODERMAL, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10419">
        <property type="entry name" value="TFIIIC_sub6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIIC triple barrel" evidence="2">
        <location>
            <begin position="38"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU45153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="400" mass="45535" checksum="DBC31585B49AA151" modified="2009-10-13" version="1">MASSLDETTLADTPAVLAIQDELERDEQEDWEYEYSTTETETYYLTLELSYPEFKDRQSRAPHHSRGGYYKNWLDHNPSQMKGIGGRDNQADNDDDNDNEPLPEPEADDDEPEIDPELNNDNNENNDKGKGVDARDTREEDGDKNQDDTEDIQILELHSQNPVIAYKGRVFEGQWAEIIGTEAIFAVRDNENPLPALRRLDGNIDFLGACASRITTTENLVKPKISREDPLAAIREEWNIRIPVGKDRSGERAQQTRFLENLIALKKQKGETDQVTVWAKDGEGKDFKDNRDPDYKPRRRRRMFNEDGEEVIPKRERRRGTGRKIGRPRGRGRGRRATSTAAPTSTRGDLGSPAQEGALSTPTPSRWNDLFEREDDGMDDDEDNQSETDDDDDGDMSMAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7YS14</accession>
    <name>C7YS14_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_93732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050878.1">
        <property type="nucleotide sequence ID" value="XM_003050832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YS14"/>
    <dbReference type="GeneID" id="9666046"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_93732"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_93732"/>
    <dbReference type="eggNOG" id="ENOG502T39P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076658_0_0_1"/>
    <dbReference type="InParanoid" id="C7YS14"/>
    <dbReference type="OMA" id="SYPENTW"/>
    <dbReference type="OrthoDB" id="4755186at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988619" evidence="2">
        <location>
            <begin position="24"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU45165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="256" mass="28801" checksum="AA0C50B6760F4502" modified="2009-10-13" version="1">MANTRNGLLLALAATGLVSSASAFDPAKDRWLCQQDDAICVTSFVWCSTNKEDSAKGCSYPNNTWPYYNRDEGDNPAMVLWDKEYTISWHGTDDDYSTLIEWHFELKNKETSYTFKFKDLAADFPTKDHDDIDAEQVKAAASNLKNLWAVSQPDRPYEGEGRVHGNPWMDKSSKFIVMDDDVLPYLETQSEKAREEERRKWEKGVAIGVGVGVPILMAAAFMIGKMFGGKREEKRSGYKSVGAYHSGYNEPNLGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSA6</accession>
    <name>C7YSA6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="11">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">NECHADRAFT_100651</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="11 14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11 14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="11"/>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051313.1">
        <property type="nucleotide sequence ID" value="XM_003051267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSA6"/>
    <dbReference type="FunCoup" id="C7YSA6">
        <property type="interactions" value="850"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YSA6"/>
    <dbReference type="GeneID" id="9666174"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100651"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100651"/>
    <dbReference type="eggNOG" id="KOG1526">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_023296_1_1_1"/>
    <dbReference type="InParanoid" id="C7YSA6"/>
    <dbReference type="OMA" id="HGTVQRH"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:isocitrate metabolic process"/>
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        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
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        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
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        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
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        <property type="entry name" value="nadp_idh_euk"/>
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        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="6 11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 11 14" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11 15" id="KW-0521">NADP</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="16">
        <location>
            <begin position="65"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="131"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="150"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="365"/>
            <end position="370"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
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    <feature type="binding site" evidence="15">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="12">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="12">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
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        </source>
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        <source>
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        <source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEU45600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="466" mass="52027" checksum="A7923FEAA03157C7" modified="2009-10-13" version="1">MPAVAFASAVPRSLLSSSLRRVAFASSSPIAVRPIRASFGAVQTISPFAVRTMASAIPKIKVKNPVVELDGDEMTRIIWQSIKDKFIYPYLDIDLKYYDLGLEYRDETNDQVTIDAAEAIKKYQVGVKCATITPDEARVEEFKLKQMWLSPNGTIRNALGGTVFREPIVIPRIPRLVPGWKKPIIIGRHAFGDQYRAKDAVLPGPGKLSMVYTPEGGEPQEIEVYQFKNGGGVAQTQYNTDESITGFAHASFKLALDKGLPLYMSTKNTILKKYDGRFKDIFQELYDTQYKPEFEAKKIWYEHRLIDDMVAQMVKSSGGYIMALKNYDGDVQSDIVAQGFGSLGLMTSVLITPDGKTFESEAAHGTVTRHYREHQKGNETSTNPIASIFAWTRGLIQRGKLDDQPEVVSFAESLEQACIDTVDIDGVMTKDLALACGKTGREDYVTTTEYLNAVERRMKNILKEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSK2</accession>
    <name>C7YSK2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_80764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051366.1">
        <property type="nucleotide sequence ID" value="XM_003051320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSK2"/>
    <dbReference type="GeneID" id="9666293"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_80764"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_80764"/>
    <dbReference type="eggNOG" id="ENOG502R35I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_264096_0_0_1"/>
    <dbReference type="InParanoid" id="C7YSK2"/>
    <dbReference type="OrthoDB" id="5347061at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="506"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="808"/>
            <end position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU45653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1269" mass="142237" checksum="48E222D89A00956E" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSX7</accession>
    <name>C7YSX7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Isocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_69753</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051438.1">
        <property type="nucleotide sequence ID" value="XM_003051392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSX7"/>
    <dbReference type="FunCoup" id="C7YSX7">
        <property type="interactions" value="118"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YSX7"/>
    <dbReference type="GeneID" id="9666346"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_69753"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_69753"/>
    <dbReference type="eggNOG" id="KOG1260">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019214_2_2_1"/>
    <dbReference type="InParanoid" id="C7YSX7"/>
    <dbReference type="OMA" id="TVPHADF"/>
    <dbReference type="OrthoDB" id="4078635at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019629">
        <property type="term" value="P:propionate catabolic process, 2-methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.850:FF:000001">
        <property type="entry name" value="Isocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF13">
        <property type="entry name" value="MITOCHONDRIAL 2-METHYLISOCITRATE LYASE ICL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="157"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="267"/>
            <end position="268"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="484"/>
            <end position="488"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="519"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU45725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="599" mass="66363" checksum="F1512DCC1AE6BB57" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7YT21</accession>
    <name>C7YT21_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_41150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051460.1">
        <property type="nucleotide sequence ID" value="XM_003051414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YT21"/>
    <dbReference type="STRING" id="660122.C7YT21"/>
    <dbReference type="GeneID" id="9668459"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_41150"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_41150"/>
    <dbReference type="eggNOG" id="ENOG502QQEA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_8_1_1"/>
    <dbReference type="InParanoid" id="C7YT21"/>
    <dbReference type="OMA" id="ANHPFDA"/>
    <dbReference type="OrthoDB" id="300709at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF11">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU45747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="310" mass="34091" checksum="7740FAA6A266B120" modified="2009-10-13" version="1">MSKILAVFGATGQQGGSVINYVLNDQELSQKYKVRAITRDVNSAKAKELDERVEVVQGDAFDLASLEAALVGVHTVFAMTTPVFGPDAFDVEYNSAKRIADVAVEKGVQYIVFSTLPSVTEISGGKYTKIVPFDAKAKAEQYIRSLPVKSAFYRPGSFMENFHSQPFWGPRQAPDGTWVISTHMSPQTRLPLIDAVGDSGKFVGAVLAEPEKFQGKTLSAATRLYSLEELAATMSKVTGQKVVYEQITPEEFAKEVPIMTEIFVEAFQYYEEFGYFGPDSESLVAWAAENARGKLSTLEEFLKAHPPQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C7YTV0</accession>
    <name>C7YTV0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rap-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_63490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050396.1">
        <property type="nucleotide sequence ID" value="XM_003050350.1"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YTV0"/>
    <dbReference type="GeneID" id="9674808"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_63490"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_63490"/>
    <dbReference type="eggNOG" id="KOG3687">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003828_0_0_1"/>
    <dbReference type="InParanoid" id="C7YTV0"/>
    <dbReference type="OMA" id="ATRFLMN"/>
    <dbReference type="OrthoDB" id="19311at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000007">
        <property type="entry name" value="Tuberous sclerosis 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018515">
        <property type="entry name" value="Tuberin-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024584">
        <property type="entry name" value="Tuberin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF0">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11864">
        <property type="entry name" value="DUF3384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03542">
        <property type="entry name" value="Tuberin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="3">
        <location>
            <begin position="1287"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="779"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="852"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1076"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1518"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1581"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1080"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1523"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1554"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1589"/>
            <end position="1603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU44683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="1624" mass="179591" checksum="CDBCF9564A729E91" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7YTY0</accession>
    <name>C7YTY0_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_63536</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050413.1">
        <property type="nucleotide sequence ID" value="XM_003050367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YTY0"/>
    <dbReference type="GeneID" id="9675198"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_63536"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_63536"/>
    <dbReference type="eggNOG" id="ENOG502SSVT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031222_1_0_1"/>
    <dbReference type="InParanoid" id="C7YTY0"/>
    <dbReference type="OMA" id="QYNSPVS"/>
    <dbReference type="OrthoDB" id="5239590at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988535" evidence="3">
        <location>
            <begin position="20"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="489"/>
        </location>
    </feature>
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        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU44700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="489" mass="53993" checksum="3A54C7A11E51B7F6" modified="2009-10-13" version="1">MRGSSLLAVGLGLLSPATSLLVASDSPCGTLCGNVLSSTTNNDIVCHEDDYTTGSGIVFQQCLACEQTSDYRTSDNETDQQYYLYNLRYAVSYCLFGIPDNKDVINTPCMTSKACGPFHDAIVYKNLSSKVDKYEYCDIWPVDDTLDFNGCTECLQAGDNHFLANFITVLQAGCEQQPSPGTLVSTEGGIFSKDNVNVTEPTPMQTVDPDWFNQGPLTLDAKVGIAFAGFAVLLVILGFAIIWRGRRRRRAFLNTLSNKPRKSWPGVTPMFGTTRDTPMSQKPLRGWDESPISVRSEKPFQQHGSPFASQYSSPVSATELKLAHWPVMAPNGSIPDLPLSEQQQQQLYQQQMYQHQLSPHIGVAMGGDEASVHTSGSKGKGKQEEEYEMTTVESPQVGMGIYQHEYIHPGYTQTGYPQPGYPQPGYPQTEHPQPGLPQREHSQNGESSRGHRRGKGSFSERLSNVDDPHTYDEDDPRSGRTPHQDGSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7YUZ1</accession>
    <name>C7YUZ1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_49364</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050606.1">
        <property type="nucleotide sequence ID" value="XM_003050560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YUZ1"/>
    <dbReference type="SMR" id="C7YUZ1"/>
    <dbReference type="ESTHER" id="nech7-c7yuz1">
        <property type="family name" value="Lipase_3"/>
    </dbReference>
    <dbReference type="GeneID" id="9674989"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_49364"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_49364"/>
    <dbReference type="eggNOG" id="KOG4569">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032957_1_0_1"/>
    <dbReference type="InParanoid" id="C7YUZ1"/>
    <dbReference type="OMA" id="PEYWISS"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="BRENDA" id="3.1.1.26">
        <property type="organism ID" value="8196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051299">
        <property type="entry name" value="AB_hydrolase_lip/est"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640:SF3">
        <property type="entry name" value="LIPASE LIH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012338870" description="Fungal lipase-type domain-containing protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="3">
        <location>
            <begin position="107"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU44893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="348" mass="37433" checksum="8AEFA8178E010F67" modified="2009-10-13" version="1">MRLLPLLSVVTLAAASPIASVQEYTDALETRAITASTLDYENFKFYIQHGAAAYCNSETASGEKITCSDSACKVVEANNVVVVASFVGTGTGIGGYVSTDDIRKEIVLSIRGSSNIRNWLTNVDFGQSGCSYVKDCGVHTGFRNAWDEIAQRARDAIAKARAKNPSYKVIATGHSLGGAVATLGGADLRSKGTAVDIFTFGAPRVGNAELSAFITSQAGGEFRVTHGRDPVPRLPPIVFGYRHTSPEYWLAGGASTKIDYSVNDIEVCEGSANLACNGGTLGLDIVAHLRYFQNTDACTAGGISWKRGDKAKRNEIPKRRDSMTDEELERKLNDYVAMDKEYVESNKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVB7</accession>
    <name>C7YVB7_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_85219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050666.1">
        <property type="nucleotide sequence ID" value="XM_003050620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVB7"/>
    <dbReference type="GeneID" id="9675055"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85219"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85219"/>
    <dbReference type="HOGENOM" id="CLU_1409141_0_0_1"/>
    <dbReference type="InParanoid" id="C7YVB7"/>
    <dbReference type="OrthoDB" id="5105559at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU44953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="193" mass="22101" checksum="7C33748CB7166588" modified="2009-10-13" version="1">MAPNKKPAHIKVFPIPRLSDTRTETNGRRFQYCDETHGAILNALLDKADEPNNLGVVLNQGFDKFHILMQKCNLGPRDRWHRKTTAIRDCVDWVRARAREHGALIFEQNRWVRGRSFKSDAEATEWLDTKISGRARPTSLNQSLPALDTLSLADSEPDEYVTQNTGRRVSFSQPSPSRSRSSSRTRRFSLRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVK6</accession>
    <name>C7YVK6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Glucanase</fullName>
            <ecNumber evidence="13">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">NECHADRAFT_73991</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyl hydrolase family 6.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU43809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049522.1">
        <property type="nucleotide sequence ID" value="XM_003049476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVK6"/>
    <dbReference type="SMR" id="C7YVK6"/>
    <dbReference type="STRING" id="660122.C7YVK6"/>
    <dbReference type="GeneID" id="9677302"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_73991"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_73991"/>
    <dbReference type="eggNOG" id="ENOG502QWHE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015488_0_0_1"/>
    <dbReference type="InParanoid" id="C7YVK6"/>
    <dbReference type="OMA" id="EVHTLAM"/>
    <dbReference type="OrthoDB" id="64893at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.40:FF:000001">
        <property type="entry name" value="Glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.40">
        <property type="entry name" value="1, 4-beta cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016288">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036434">
        <property type="entry name" value="Beta_cellobiohydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001524">
        <property type="entry name" value="Glyco_hydro_6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876:SF4">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01341">
        <property type="entry name" value="Glyco_hydro_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001100">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00733">
        <property type="entry name" value="GLHYDRLASE6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51989">
        <property type="entry name" value="Glycosyl hydrolases family 6, cellulases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00655">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00656">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 13" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005125797" description="Glucanase" evidence="13">
        <location>
            <begin position="19"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="15">
        <location>
            <begin position="27"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="69"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="69"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 12">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEU43809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="468" mass="49692" checksum="B818C0EBB93D7A24" modified="2009-10-13" version="1">MTAYKLLFTAALAGTAFAAPLVEERQACAAQWAQCGGFSWNGATCCQSGSYCSKINDYYSQCIPGEGPATSKSSTLPASTTTTQPTSTSTAGTSSTTKPPPAGSGTATYSGNPYSGVNLWANSYYRSEVTNLAIPKLSGAMATAAAKVADVPSYQWMDSFDHISLMEDTLVDIRKANLAGGNYAGQFVVYDLPDRDCAAAASNGEYSLDNDGANKYKNYIQTIKKIIQSYSDIRILLVIEPDSLANLVTNMDVAKCAKAHDAYISLTNYAVTELNLPNVAMYLDAGHAGWLGWPANQGPAAKLFASIYKDAGKPAALRGLATNVANYNAWSLSSAPPYTQGASIYDEKSFIHAMGPLLEQNGWPGAHFITDQGRSGKQPTGQIQWGDWCNSKGTGFGIRPSANTGDSLLDAFVWVKPGGESDGTSDTSATRYDYHCGASAALQPAPEAGTWFQAYFEQLLTNANPSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVM9</accession>
    <name>C7YVM9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_74014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049739.1">
        <property type="nucleotide sequence ID" value="XM_003049693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVM9"/>
    <dbReference type="GeneID" id="9677471"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74014"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74014"/>
    <dbReference type="eggNOG" id="ENOG502RJ3C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_685284_0_0_1"/>
    <dbReference type="InParanoid" id="C7YVM9"/>
    <dbReference type="OrthoDB" id="5421765at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU44026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="402" mass="44385" checksum="C2EB439641301040" modified="2009-10-13" version="1">MAELVPAGVLGTITYHIITLAIETGQANDEVRRSLELVRTCDRDLQHLISLRDEHLDILERKPIEFERINLIIEDAHKGLLEVGRIVEKCRPEANRGKLPFGKRGRWVLFDSKQFNSQVPVINGHHQAVLTEITFLRQIALHIPTPVQDQVVHAGANLAQRKRVAIDNVNLLGSLMGRKLATRHSMSAPQASPVDSAVDPHNSQSTPPSLPPKPPSYQSPNFVATSFAKHISLADIQASRGSASTMYDPFPPTSYTQPPGFSAVPPQFVQEQLSTGATPAQYRSPSPFSFSGPQSQYQGSPAYPSNIPSQPTPAPSYRSTQTQWSNGQAYLRGNTAELTEGGVRPGDTRQARDLRDLDWESQPASEANTTREMPRSDLGRRNISAQATSTASFQNWGDWNRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVQ0</accession>
    <name>C7YVQ0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CHR2128</name>
        <name evidence="7" type="ORF">NECHADRAFT_74036</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU43830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049543.1">
        <property type="nucleotide sequence ID" value="XM_003049497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVQ0"/>
    <dbReference type="STRING" id="660122.C7YVQ0"/>
    <dbReference type="GeneID" id="9677325"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74036"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74036"/>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_2_7_1"/>
    <dbReference type="InParanoid" id="C7YVQ0"/>
    <dbReference type="OMA" id="QIEAMRM"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="437"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="853"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU43830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1043" mass="116773" checksum="F20001CCF038EF05" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C7YVS7</accession>
    <name>C7YVS7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NECHADRAFT_65053</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15938"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:15939"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU43844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049557.1">
        <property type="nucleotide sequence ID" value="XM_003049511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YVS7"/>
    <dbReference type="STRING" id="660122.C7YVS7"/>
    <dbReference type="GeneID" id="9677338"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_65053"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_65053"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_2_1"/>
    <dbReference type="InParanoid" id="C7YVS7"/>
    <dbReference type="OMA" id="GPAWFVF"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000158">
        <property type="entry name" value="Zinc-binding alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="17"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEU43844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="362" mass="38816" checksum="94EB06EDC079C875" modified="2009-10-13" version="1">MSTDYEFQGWLGHSPDAVNGKMEWGPFEPKKWEEDDVDIQITHCGICGSDLHMLRSGWGETPYPCCVGHEIVGKAVRVGSNVKDISVGDRVGVGAQARSCLRDDCPACSVGLYNYCKNGINTYGSIYPGDVGKSYGGYADYNRTDSRFVVKIPDGLASEDAAPMLCGGVTVYTPLRNNGCGPGKTVGIVGVGGLGHFGVLFAKALGADKVIGISRRASKRDEVLALGADEYIATEDDEDWATKHAQSIDLIISTVSSPKMPLTQYLGLLRYGGNFIQVGAPDGGELPPINAFTLIAGGFKVGGSAIGSPSDIKEMLQLAVDKKIKPWVEKRSLKDANQAVKDMEAGKARYRYVLVNEKHAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWD0</accession>
    <name>C7YWD0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_74260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049871.1">
        <property type="nucleotide sequence ID" value="XM_003049825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWD0"/>
    <dbReference type="GeneID" id="9677446"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74260"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74260"/>
    <dbReference type="eggNOG" id="ENOG502T15A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053751_0_0_1"/>
    <dbReference type="InParanoid" id="C7YWD0"/>
    <dbReference type="OMA" id="RIYYWAY"/>
    <dbReference type="OrthoDB" id="5413827at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU44158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="33225" checksum="E0A6D176BF4F3866" modified="2009-10-13" version="1">MDITSDDATPRSVPDLPEKAHERKLTLLSLPLEIRLHIYHWLHLMSPVRHAQLAPWYPTPVHCQYILRPLDHILRPLNHEAEPDGGEAKGLLSPYRPLSGLPTSLLRANSQIYHEARLIPFSQNEFVFVNWFASGLWAARAFTRALAPWQRGALRYVRLEVLARDVVVGGAGREEWRALCGEWASGVRGLRMKMVLGSSTATVSGPSAGGGMGPRSEAARQWVGEGLGLMRKLERVEMEVVSRGMSDEAKMLWCEKLERELREGGLKWAVVVCAEKVHERMEWIKSDVAWKNQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWS0</accession>
    <name>C7YWS0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_82762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049166.1">
        <property type="nucleotide sequence ID" value="XM_003049120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWS0"/>
    <dbReference type="GeneID" id="9666554"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82762"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82762"/>
    <dbReference type="eggNOG" id="ENOG502REQ7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1992168_0_0_1"/>
    <dbReference type="InParanoid" id="C7YWS0"/>
    <dbReference type="OMA" id="EWRAFYR"/>
    <dbReference type="OrthoDB" id="10042947at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU43453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="12757" checksum="D740760ED1522783" modified="2009-10-13" version="1">MVSPVQITITAFGVSAFVSGVSTLINPSYTLEFLNLPLAALPSVRGNALAAIGMGIYYSLAAYQNNTAFFAASVPMRLLSASIFWVQGWQVASIWEGTGSIATGLALLWQLRLEKNKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7YX92</accession>
    <name>C7YX92_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_95089</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049260.1">
        <property type="nucleotide sequence ID" value="XM_003049214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YX92"/>
    <dbReference type="STRING" id="660122.C7YX92"/>
    <dbReference type="ESTHER" id="nech7-c7yx92">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="9676932"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_95089"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_95089"/>
    <dbReference type="eggNOG" id="KOG1516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_15_2_1"/>
    <dbReference type="InParanoid" id="C7YX92"/>
    <dbReference type="OMA" id="RSQPVFQ"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
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</entry>
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                <person name="Molnar I."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
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        </location>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
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</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
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                <person name="Rodriguez-Carres M."/>
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                <person name="Grimwood J."/>
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                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
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                <person name="Nelson D.R."/>
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                <person name="Salamov A."/>
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                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048959.1">
        <property type="nucleotide sequence ID" value="XM_003048913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYS5"/>
    <dbReference type="STRING" id="660122.C7YYS5"/>
    <dbReference type="GeneID" id="9665956"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_71093"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_71093"/>
    <dbReference type="eggNOG" id="KOG2167">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004747_7_0_1"/>
    <dbReference type="InParanoid" id="C7YYS5"/>
    <dbReference type="OMA" id="NYQEQTW"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000031">
        <property type="entry name" value="Ubiquitin ligase subunit CulD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="7">
        <location>
            <begin position="413"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU43246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="795" mass="90625" checksum="94843ABCB2FF17AF" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZ41</accession>
    <name>C7YZ41_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_62944</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049012.1">
        <property type="nucleotide sequence ID" value="XM_003048966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZ41"/>
    <dbReference type="STRING" id="660122.C7YZ41"/>
    <dbReference type="GeneID" id="9665674"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_62944"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_62944"/>
    <dbReference type="eggNOG" id="KOG0663">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="InParanoid" id="C7YZ41"/>
    <dbReference type="OMA" id="WVARATN"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07843">
        <property type="entry name" value="STKc_CDC2L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000054">
        <property type="entry name" value="Cyclin-dependent kinase 11B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000211">
        <property type="entry name" value="Cyclin-dependent kinase G-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045267">
        <property type="entry name" value="CDK11/PITSLRE_STKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="97"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="390"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU43299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="455" mass="51088" checksum="7ED4614AF83517DF" modified="2009-10-13" version="1">MSSKGRWADTEEDARQDAKLKEEKRRKKAERVRKLEAEKQAQAAAARASLDVDDDRPSKRRRITPEPGAGANEKQPPAKLLRFPTGGWSKCRSVENYEKLNDIEEGTYGWVARATDKATGKVVALKRLKLDPADRNGLPVTGLREIQILKDCQHRNIVSMVEVVVGDDVSRPDNSLFLVLEFVEHDLKSILEDMPEPFLSSEVKRLLLQLTSGIAYLHDNWILHRDLKTSNLLLNNRGQLRIADFGMARYVGDPPPKLTQLVVTLWYRAPELLLGAKSYGAAVDMWSVGCIFGELLTREPLLQGKNEVDQVSRIFELCGVPTDESWPGFRRLPNARTLRLPKTAAASGSVVRARFPGLTSAGAGLLADLLSLDPDRRPTAREMLQHEYFRQDPKPKPESMFPTFPSKAGQERRRRQEPHAPVRGQAASLGDVDFTGIFQGRDREERGAGFQLRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z1N4</accession>
    <name>C7Z1N4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_50734</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="protein sequence ID" value="EEU42029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003047696.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="9671527"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_50734"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_50734"/>
    <dbReference type="eggNOG" id="ENOG502QWAA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024810_3_1_1"/>
    <dbReference type="InParanoid" id="C7Z1N4"/>
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    <dbReference type="OrthoDB" id="18453at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
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        <location>
            <begin position="12"/>
            <end position="144"/>
        </location>
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        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
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        <location>
            <begin position="411"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEU42029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="438" mass="49375" checksum="582F782A46324864" modified="2009-10-13" version="1">MSSSEILTASQLNSISIIERVCSVFSLLGSLFVIGTFVSSKAFHKPINRLVFYASFGNMMTNVGTLMSRQYLGSPSSVGCQFQAFLIQMFMPADAFWTLSMAINVYLTFYFKFDARRLRKMEIPYLVGCYGIPFIPAFVYIFIKNKQGERMYAGTKANADIHRVVIAITFFIYIRAGHTIYRKRRDLDNFSSTDQDLTSLGDALATIKTTEVSVTTEVMSPNAIHLQPMGRRAPDVNSPQDTNGAYSVTISADTSSGDVADVVLPIQQQQTRTSMQVPPVQRNPARRRNRELNNAAWQYTKCALLFFTAILITWIPSSANRVYAVFHTKHSSVPLEFMSAFVLPLQGFWNALIYMVTSWGACKSLLSDLRMGRRPDVTELVGGMAPEISVHHHHHHRHNLSQFRANTRSNKYETESMTELANESRPTSDDGRRDNIHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z2I4</accession>
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        <submittedName>
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        </submittedName>
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        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
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    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="261" mass="30004" checksum="F2543B1875A2F9FD" modified="2009-10-13" version="1">MRFITDNKPRQDQGKEVPLMVIGAGLPRAATSSLQAALEKIGFAPCLHMAEIIPHVDRMQLLLEAVREKDTEVRHKMLRKLIHGHYAICDLPVVFFTPDLMDMYPDVKIVLNGRPDPDVWARSAADSFGFVFSPWFKWTGLLWTTDRIWYKLNQESEKYCQELFGDGDIFTGRCYREYYDMVRAEAKKRGKEVLEFKAEDGYEPLCKFLGKDAPDEPFPKLNEKKTFQVVQAILIARGLLAWSALGVGCWGAWKLADHFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z350</accession>
    <name>C7Z350_FUSV7</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">NECHADRAFT_53945</name>
    </gene>
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        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
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            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
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        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
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    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003047267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z350"/>
    <dbReference type="GeneID" id="9676229"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_53945"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_53945"/>
    <dbReference type="eggNOG" id="ENOG502TEVV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153353_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z350"/>
    <dbReference type="OMA" id="REWEHKG"/>
    <dbReference type="OrthoDB" id="4779541at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU41600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="139" mass="14979" checksum="C71187F6EAD19F30" modified="2009-10-13" version="1">MSKLVEDVKSGLKGIRGAGDAVRGEVLKATDQAFEKNPDHPTTVESRTENEATAEKGKKDLRGADEMLARHEWKRKGVTPAQGAAASENQPVHESDRPAETLHREPGTIAPGETTHYGTGRVEESGAVAPDVSEKHRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z375</accession>
    <name>C7Z375_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Infection structure specific protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_87853</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047321.1">
        <property type="nucleotide sequence ID" value="XM_003047275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z375"/>
    <dbReference type="GeneID" id="9676238"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_87853"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_87853"/>
    <dbReference type="eggNOG" id="ENOG502SSM3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118708_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z375"/>
    <dbReference type="OMA" id="TSWQAQH"/>
    <dbReference type="OrthoDB" id="5104384at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988897" description="Infection structure specific protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU41608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="22318" checksum="5F1ACAAEA8FBC38B" modified="2009-10-13" version="1">MHTFKLLLVATAALQAAAQTRIPTETGVISEPPLESLGIGTACATIVSSFAADATDAPVPDRSISNIAMAFALGRMYNTEDPCKLPSITERDSASAFTAWASSYTEWQSGQIPDYRQVWTACSDEPLVSEIIPIGSSVCSSLAAEITGGSGSNNDGDNDEDDDNEDSGSDGDRRDSNDDSNDSNSNDDGNTGFQQAVPVLSAAVVAGLIILGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z3E0</accession>
    <name>C7Z3E0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_54099</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="GG698907">
        <property type="protein sequence ID" value="EEU41639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047352.1">
        <property type="nucleotide sequence ID" value="XM_003047306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z3E0"/>
    <dbReference type="STRING" id="660122.C7Z3E0"/>
    <dbReference type="GeneID" id="9676343"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_54099"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_54099"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z3E0"/>
    <dbReference type="OMA" id="IHKVAPA"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07106">
        <property type="entry name" value="ALDH_AldA-AAD23400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044086">
        <property type="entry name" value="LUC3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="25"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU41639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="481" mass="51375" checksum="3A644B3A2A0A339C" modified="2009-10-13" version="1">MAVGTNVKLNFTEFFNITDGKLETTKETVQGVNPSTLEQNPPVPVSTREDVDRTVQAAKKASEAWADVPYKERQAMLAKFADGIDSIKDELVVLLNKEQGKPLQLAHVEIGMAIHFLKGYSQLPDPEEVIEDKPGRRIVTKYVPLGVAVGIVPWNFPVFIAAAKIGPALVAGNAFILKPSPFTPYCDLKLAELALTYFPVGVVQALSGNDDLGPWLTAHPGVDKISFTGSTATGKRVLQSAAGTLKRVTLELGGNDPAIVCSDVNVKEVAPKLAMGALANSGQLCIAIKRIYVHESIYDDLLEALAATVKSLPVGDGLASGTAMGPVQNNLQFDRVKSLLADIQSHDLKLAAGSTGPSDAGKGYFITPTVVDNPPDASRIVVEEPFGPVFPVLKWKDENEVLRRDNDSPMGLGASVWTPDLEKAERLAAKLKVGTVWINSHHELNPSVPFGGAKESGIGAEHGLEGIKSYCNTKSVFINAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z3Y4</accession>
    <name>C7Z3Y4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribosome biogenesis protein Alb1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_83411</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698909">
        <property type="protein sequence ID" value="EEU41384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003047097.1">
        <property type="nucleotide sequence ID" value="XM_003047051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z3Y4"/>
    <dbReference type="GeneID" id="9678675"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83411"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83411"/>
    <dbReference type="eggNOG" id="ENOG502SC3P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085138_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z3Y4"/>
    <dbReference type="OMA" id="DWEDTNR"/>
    <dbReference type="OrthoDB" id="5304887at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053278">
        <property type="entry name" value="Pre-60S_factor_ECM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022784">
        <property type="entry name" value="Ribosome_bgen_Alb1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28280">
        <property type="entry name" value="SHUTTLING PRE-60S FACTOR ECM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28280:SF1">
        <property type="entry name" value="SHUTTLING PRE-60S FACTOR ECM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09135">
        <property type="entry name" value="Alb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="114"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU41384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="18252" checksum="2AB7527FD37C2731" modified="2009-10-13" version="1">MAKKRAPSIHSRAARRATSPSIDADKSLKDVKPPPRSAPHRPSVLAAQHSAGVSKKSKRKTAMSAKARRRHEKGLEMAEAVIERTKSKVEKSKGRGRNIHLRSKAWEEINKVAATEGEVEGDEVEKRNGGVELDEDMGGADEETLTAPVVPDAAPAAVPLPVDDDDEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4G3</accession>
    <name>C7Z4G3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA 4-demethylwyosine synthase (AdoMet-dependent)</fullName>
            <ecNumber evidence="4">4.1.3.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">NECHADRAFT_33081</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:36347"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10165"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="EC" id="4.1.3.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TYW1 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.44" evidence="4"/>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046631.1">
        <property type="nucleotide sequence ID" value="XM_003046585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4G3"/>
    <dbReference type="FunCoup" id="C7Z4G3">
        <property type="interactions" value="648"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z4G3"/>
    <dbReference type="GeneID" id="9678162"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_33081"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_33081"/>
    <dbReference type="eggNOG" id="KOG1160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007952_1_2_1"/>
    <dbReference type="InParanoid" id="C7Z4G3"/>
    <dbReference type="OMA" id="FHVNGKW"/>
    <dbReference type="OrthoDB" id="271553at2759"/>
    <dbReference type="UniPathway" id="UPA00375"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102521">
        <property type="term" value="F:tRNA-4-demethylwyosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034556">
        <property type="entry name" value="tRNA_wybutosine-synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930:SF0">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE TYW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00284">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01071">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="14">
        <location>
            <begin position="119"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="15">
        <location>
            <begin position="436"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="298"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="732"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="756"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEU40918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="772" mass="87758" checksum="86EC1B59FF6903E8" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z4V6</accession>
    <name>C7Z4V6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA 3'-terminal phosphate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_32251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046701.1">
        <property type="nucleotide sequence ID" value="XM_003046655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z4V6"/>
    <dbReference type="STRING" id="660122.C7Z4V6"/>
    <dbReference type="GeneID" id="9678235"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_32251"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_32251"/>
    <dbReference type="eggNOG" id="KOG3980">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027882_3_1_1"/>
    <dbReference type="InParanoid" id="C7Z4V6"/>
    <dbReference type="OMA" id="HAKTARW"/>
    <dbReference type="OrthoDB" id="25029at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003963">
        <property type="term" value="F:RNA-3'-phosphate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF0">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU40988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="396" mass="42990" checksum="23ACBA5CF2918AF5" modified="2009-10-13" version="1">MKPLEISGTTGEGGGQLVRTAIALSALTGQAVTISDIRGGRERGGNQHATAIQFLAEATDADVEGLTVGSKTVTFCPRRGPADLLRRNISISAESGSASTLLILQAILPFLVFAGNESDEPVELEISGGTNVSFSLSFEYLDQVLLPTLEDRFSIRVERRLIRRGWSLGPQSRGKIWIKLFPLKAGQSLRFKAPERPQACEVKSIDVSMVVPISVQEKLQASLTKDLAGLYPGSDVHFKLVEDSNLDSRWYILLVAHSGSGIRWGHDFLGSMPKKTKNRDNFAAQISSKVCRGLYGETSAGGQADIHLQDQVVVFQALCDGYSSLPRNDESSPDILIDAMGNLDIGNGRMRKEKTHEPFGHGSLHAQTARWLVSELLPSVEFYNKGDLVKGTGTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z590</accession>
    <name>C7Z590_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Survival protein SurE-like phosphatase/nucleotidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_58510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU41058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046771.1">
        <property type="nucleotide sequence ID" value="XM_003046725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z590"/>
    <dbReference type="FunCoup" id="C7Z590">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z590"/>
    <dbReference type="GeneID" id="9678576"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_58510"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_58510"/>
    <dbReference type="eggNOG" id="KOG2157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007204_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z590"/>
    <dbReference type="OMA" id="TNTCFQE"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027746">
        <property type="entry name" value="TTL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU41058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="712" mass="79378" checksum="1212C82894AFD04B" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6C4</accession>
    <name>C7Z6C4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_57861</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045821.1">
        <property type="nucleotide sequence ID" value="XM_003045775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6C4"/>
    <dbReference type="SMR" id="C7Z6C4"/>
    <dbReference type="FunCoup" id="C7Z6C4">
        <property type="interactions" value="969"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z6C4"/>
    <dbReference type="GeneID" id="9667941"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_57861"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_57861"/>
    <dbReference type="eggNOG" id="KOG1541">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055194_0_2_1"/>
    <dbReference type="InParanoid" id="C7Z6C4"/>
    <dbReference type="OMA" id="WIQEKKE"/>
    <dbReference type="OrthoDB" id="2877at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000017">
        <property type="entry name" value="probable 18S rRNA (Guanine-N(7))-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039769">
        <property type="entry name" value="Bud23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022238">
        <property type="entry name" value="Bud23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734:SF0">
        <property type="entry name" value="18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12589">
        <property type="entry name" value="WBS_methylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="9">
        <location>
            <begin position="52"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal" evidence="10">
        <location>
            <begin position="213"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU40108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="30408" checksum="5BC435B9723A15B5" modified="2009-10-13" version="1">MSRPEDTLAADVHYDDIEARKYTTSSRIQNIQASMTRRALELLDLKGPSLILDVGCGSGLSGEILSSLEPEENGPHTWIGMDVSPSMLDIALQRDVEGDLMLADIGQGVPFRAGTFDAAISISAIQWLCSAETSDTSPAGRLSRFFNGLYASLKRGGRAVCQFYPKNDQQRNMITQAAVKAGFGAGLLEDDPGTKNVKLYLVLTVGGGSLESKGGDITGVVEGMDDIDVQDARRTIKNNNTAMKKGSKAWIIKKKEQMERKGKIVKATSKYTGRKRRIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6K3</accession>
    <name>C7Z6K3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_57904</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046421.1">
        <property type="nucleotide sequence ID" value="XM_003046375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6K3"/>
    <dbReference type="STRING" id="660122.C7Z6K3"/>
    <dbReference type="GeneID" id="9668694"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_57904"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_57904"/>
    <dbReference type="eggNOG" id="KOG3246">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043678_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z6K3"/>
    <dbReference type="OMA" id="GFYFEYL"/>
    <dbReference type="OrthoDB" id="5065855at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019784">
        <property type="term" value="F:deNEDDylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.395.10:FF:000008">
        <property type="entry name" value="Ulp1 protease family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044613">
        <property type="entry name" value="Nep1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468:SF1">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="27"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="239"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="262"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="294"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU40708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="345" mass="39258" checksum="7B9499F701EBEC6F" modified="2009-10-13" version="1">MPFRQRMARHFGDSLAPEKPYLSYYDVLLTAEDIKSLKHDWLTDNNIAFWEEYLERETLPRYPQARIVLLRPSMTFLLMKEPDLRSVRSALPDFSKVTHVFLPINDNRNVGVAEGGSHWSLLLVSTLDGVAFHYDSLGGANYAEANLATRKLATVLQRPLRFINLEDCPQQENGSDCGVFVCLLMRHLLVKRLLCANAREKVSMSMGGKMVDSYGGRKEMLRIIENLRKEEFEERLQNLMRRRSVTKPKAKATTKKKLPSGRKVDKGRSDAAEPEKSDLPPWTGMRSRLRPRTRSISQSSSSPSSSDPSYRVTKPETRSRSSKSLTPVKVRSKRQPKADSDADSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6N8</accession>
    <name>C7Z6N8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF803 domain membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_33416</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045879.1">
        <property type="nucleotide sequence ID" value="XM_003045833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6N8"/>
    <dbReference type="STRING" id="660122.C7Z6N8"/>
    <dbReference type="GeneID" id="9668713"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_33416"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_33416"/>
    <dbReference type="eggNOG" id="KOG2922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012349_5_2_1"/>
    <dbReference type="InParanoid" id="C7Z6N8"/>
    <dbReference type="OMA" id="KNAWWWL"/>
    <dbReference type="OrthoDB" id="6428174at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF92">
        <property type="entry name" value="SPICHTHYIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="406"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="537"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="591"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU40166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="607" mass="67068" checksum="BC6E39721E4AAF0A" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6R9</accession>
    <name>C7Z6R9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_90816</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 13">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 13">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003046456.1">
        <property type="nucleotide sequence ID" value="XM_003046410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6R9"/>
    <dbReference type="FunCoup" id="C7Z6R9">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z6R9"/>
    <dbReference type="GeneID" id="9668725"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90816"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90816"/>
    <dbReference type="eggNOG" id="KOG0372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_8_1_1"/>
    <dbReference type="InParanoid" id="C7Z6R9"/>
    <dbReference type="OMA" id="KIGGYPP"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901525">
        <property type="term" value="P:negative regulation of mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000040">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="114"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU40743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="320" mass="36289" checksum="555385F6F371D422" modified="2009-10-13" version="1">MPGLPSSVDLDECISRLYKKELLAESVIEAICAKTKELLMRESNVVHVRAPITVVGDIHGQFFDLIEIFRIGGYCPDTNYLFLGDYVDRGMFSVETISLLVCLKLRYPNRVHLIRGNHESRGVTQSYGFYTECSRKYGNANVWHYFTDMFDFLTLSVVINDQIFCVHGGLSPSIHSIDQIKIIDRFREIPHEGPMADLVWSDPDPERDEFSLSPRGAGYTFGAQVVKKFLAVNNMSHILRAHQLCQEGFQVLYDDRLSTVWSAPNYCYRCGNMASVLEVSDTGERFFNVFAAAPENDMHKELQPGNEKSADGNALPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z6S1</accession>
    <name>C7Z6S1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_90818</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698910">
        <property type="protein sequence ID" value="EEU40178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045891.1">
        <property type="nucleotide sequence ID" value="XM_003045845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z6S1"/>
    <dbReference type="STRING" id="660122.C7Z6S1"/>
    <dbReference type="GeneID" id="9668093"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90818"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90818"/>
    <dbReference type="eggNOG" id="ENOG502SDVN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022382_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z6S1"/>
    <dbReference type="OMA" id="HSRDHRN"/>
    <dbReference type="OrthoDB" id="3550095at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="388"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="412"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="479"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="538"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="559"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU40178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="666" mass="74904" checksum="CB5558671AB49AEE" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z7V9</accession>
    <name>C7Z7V9_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_60557</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045606.1">
        <property type="nucleotide sequence ID" value="XM_003045560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z7V9"/>
    <dbReference type="STRING" id="660122.C7Z7V9"/>
    <dbReference type="GeneID" id="9672506"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_60557"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_60557"/>
    <dbReference type="eggNOG" id="KOG1185">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_4_0_1"/>
    <dbReference type="InParanoid" id="C7Z7V9"/>
    <dbReference type="OMA" id="DMCFPGD"/>
    <dbReference type="OrthoDB" id="2867507at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02002">
        <property type="entry name" value="TPP_BFDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006203">
        <property type="entry name" value="PRK08327.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF164">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="4">
        <location>
            <begin position="208"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="5">
        <location>
            <begin position="414"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU39893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="585" mass="62984" checksum="A7657A91E8122625" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z818</accession>
    <name>C7Z818_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_39507</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045636.1">
        <property type="nucleotide sequence ID" value="XM_003045590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z818"/>
    <dbReference type="GeneID" id="9672403"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_39507"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_39507"/>
    <dbReference type="eggNOG" id="ENOG502SNEG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037663_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z818"/>
    <dbReference type="OMA" id="QMAWDEL"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="111"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU39923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="417" mass="48639" checksum="DB8C4935520C97A1" modified="2009-10-13" version="1">MIDEDSKYFSLSGDVRIGGPSTWHITDWDQRRVISVTMDDEQDDESIAIQHLRRHSSKLPPSVYRIHVSNTGEIITAYTDAENDETCCVHYPRLEEISLPEGVRTIRRDRLEELERLGPDTDLVTYPPCSSEPVNKVVFKYYFLWQYAQKSWKEMNLWMRLPCHPNIVPFDRVVLDELEGRVVGFTNRYVSGGTLEEDKSRIFRLKWLQQLIQVVDDLNLRYGISHQDIAPRNLVVDEPSDSIMLLDFNFAARINRPATEDGEGEWHDENRNDVKGVIFTIYEIITRDNSFRDAPHEEQSIDSLPLEWVKHQEVQLDRPIVEYRQALQEWRDRRALDPGSRDVPKAINWPPRPKPPKVSIPMADVHGSPCSITMDQWYERRQAIIRRGGKVLNWERPPQKVLDDGRRLLSTGKVIDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8B8</accession>
    <name>C7Z8B8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Xanthine/uracil permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_79732</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698911">
        <property type="protein sequence ID" value="EEU39970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045683.1">
        <property type="nucleotide sequence ID" value="XM_003045637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8B8"/>
    <dbReference type="GeneID" id="9672583"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79732"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79732"/>
    <dbReference type="eggNOG" id="ENOG502QQ5E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024508_3_2_1"/>
    <dbReference type="InParanoid" id="C7Z8B8"/>
    <dbReference type="OMA" id="WPQAMGM"/>
    <dbReference type="OrthoDB" id="431212at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005345">
        <property type="term" value="F:purine nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015853">
        <property type="term" value="P:adenine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015854">
        <property type="term" value="P:guanine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="XANTHINE/URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337:SF1">
        <property type="entry name" value="XANTHINE_URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="477"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU39970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="567" mass="61121" checksum="568C12044DA99D3E" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8M2</accession>
    <name>C7Z8M2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase III subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_100852</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the RNA polymerase III (Pol III) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the eukaryotic RPC7 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU38981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044694.1">
        <property type="nucleotide sequence ID" value="XM_003044648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8M2"/>
    <dbReference type="STRING" id="660122.C7Z8M2"/>
    <dbReference type="GeneID" id="9673186"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100852"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100852"/>
    <dbReference type="eggNOG" id="ENOG502RZ0V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072641_1_0_1"/>
    <dbReference type="InParanoid" id="C7Z8M2"/>
    <dbReference type="OMA" id="ADPYENT"/>
    <dbReference type="OrthoDB" id="5377312at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024661">
        <property type="entry name" value="RNA_pol_III_Rpc31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11705">
        <property type="entry name" value="RNA_pol_3_Rpc31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000777">
        <property type="entry name" value="RNA_polIII_C31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="206"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="208"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU38981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="265" mass="28933" checksum="E0B521D9C4B357AD" modified="2009-10-13" version="1">MSRGGRGGGRGGRGGGRGGRPNVPWDTGEEPDARPSELFPPYVVPTARQLATTEQSAVQHLLLLRRQIHGSPLYTSKRTAINDPTVPRKHYGQAQANARFGVKSKASLDPFTAVPTYSHKFVREERALPDWSNRPVCRELFPSELYDTIDAAATTGGVGGKGFKRRKLELSNISALPSAEEAFGLAGDGEDEMQGKNLLERLQALKEEEGDEIADLEDEEAADEDDQDEVYDDEDAGDYDAENYFDNGDEFGDDYGDDGDGEGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z8Z8</accession>
    <name>C7Z8Z8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Poly A polymerase head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_94217</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU38913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044626.1">
        <property type="nucleotide sequence ID" value="XM_003044580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z8Z8"/>
    <dbReference type="FunCoup" id="C7Z8Z8">
        <property type="interactions" value="151"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z8Z8"/>
    <dbReference type="GeneID" id="9673035"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_94217"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_94217"/>
    <dbReference type="eggNOG" id="KOG2159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019592_2_0_1"/>
    <dbReference type="InParanoid" id="C7Z8Z8"/>
    <dbReference type="OMA" id="WQKFLDH"/>
    <dbReference type="OrthoDB" id="445712at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CC tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:CCA tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000019">
        <property type="entry name" value="tRNA nucleotidyltransferase cca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3090.10">
        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734:SF5">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734">
        <property type="entry name" value="TRNA-NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81891">
        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly A polymerase head" evidence="7">
        <location>
            <begin position="81"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding" evidence="8">
        <location>
            <begin position="254"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU38913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="569" mass="64352" checksum="8B1D2905AC921F82" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z905</accession>
    <name>C7Z905_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA-splicing endonuclease subunit Sen34</fullName>
            <ecNumber evidence="5">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_44076</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="5"/>
    <dbReference type="EMBL" id="GG698912">
        <property type="protein sequence ID" value="EEU39314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003045027.1">
        <property type="nucleotide sequence ID" value="XM_003044981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z905"/>
    <dbReference type="FunCoup" id="C7Z905">
        <property type="interactions" value="166"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z905"/>
    <dbReference type="GeneID" id="9673012"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_44076"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_44076"/>
    <dbReference type="eggNOG" id="KOG4133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049366_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z905"/>
    <dbReference type="OMA" id="RTFSLEW"/>
    <dbReference type="OrthoDB" id="48041at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000008">
        <property type="entry name" value="tRNA-splicing endonuclease subunit Sen34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016690">
        <property type="entry name" value="TSEN34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059049">
        <property type="entry name" value="TSEN34_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26577">
        <property type="entry name" value="TSEN34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017250">
        <property type="entry name" value="tRNA_splic_SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TSEN34 N-terminal" evidence="9">
        <location>
            <begin position="8"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="8">
        <location>
            <begin position="202"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="121"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00059865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR017250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF26577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU39314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="287" mass="31301" checksum="6206ECF5E0F128C0" modified="2009-10-13" version="1">MPSDPAPVRISNIAGRYLIFDSDAAALLRRNENVNGTLAGTAPQQPTQNIFLGLPVELRPEEAESLVQKKVAFLVDDVAAHQAALRSPNPEAKRLYLDSLKTRKQTAQQVFAEKNAKRAMEVAEKHGRPRPTASRTTPSNADDDALFSSDQPEPNPRQTDAAFKSLGVTPTSSGSLISPEAERTYLAEKPTTGPLCGFLLTSGYYMTPGLRFGAKYSVYPGDPLRFHAHFMANQYGWEEEIPVLDIVAGGRLATAVKKAFLVGSKQPGDEELPDGKMRTFSIEWAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZB48</accession>
    <name>C7ZB48_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_83205</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044458.1">
        <property type="nucleotide sequence ID" value="XM_003044412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZB48"/>
    <dbReference type="STRING" id="660122.C7ZB48"/>
    <dbReference type="GeneID" id="9670780"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83205"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83205"/>
    <dbReference type="eggNOG" id="KOG3923">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034311_3_0_1"/>
    <dbReference type="InParanoid" id="C7ZB48"/>
    <dbReference type="OMA" id="WAGAVWM"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF11">
        <property type="entry name" value="D-ASPARTATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="4"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU38745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="342" mass="38475" checksum="0A39C92B621C659B" modified="2009-10-13" version="1">MVKITILGAGVTGMTIASQLPIDYKVTIVGKHLPGDPEDFNFASNWAGACWVGVPDSSPRDQKLQLDSYAGLWRLASEHPDSGLRISQVTEIMETGSPDTIWFHDKIRGFQFLKSDELPARATWGMTYQSIIISPPVFLKWLRTRLEVRGVEFKRMSVENLDELRSLGHDILVNASGASSKHLPGVADKTLIPCRLQSIVMEKDWDQGFIYRGRDGFYFNIFGRPDGTCYVGGFKDFGLDDRTVYDDQRQTILTRGHHVLPNVMESDRPEDYKILYDIATSYMLRRQEHGGARVEREVINGQKVVHAYGQEAGGFTYSFGMARAASELVAQYAYELPISSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZBH1</accession>
    <name>C7ZBH1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_45833</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698914">
        <property type="protein sequence ID" value="EEU38736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044449.1">
        <property type="nucleotide sequence ID" value="XM_003044403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZBH1"/>
    <dbReference type="STRING" id="660122.C7ZBH1"/>
    <dbReference type="GeneID" id="9670763"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45833"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45833"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="InParanoid" id="C7ZBH1"/>
    <dbReference type="OMA" id="FNPGNLQ"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF236">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU38736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="32501" checksum="3FD7F292FA89352A" modified="2009-10-13" version="1" fragment="single">QVFIVTGGYVGVGYQLSRILHQRHGTVYIAGRSKQKAEAAISAIEKENPSSRGRLEFLELDLADLASVARAASDFMSREDRLDVLTNNAGVCEPPVGSRTCQGHELQMGTNCLGPFLFTKLLLPILRKTASAALTGVRVTWAGSLGADLQSPPDGIQFDGDGSPRNHTSQGVNYGQSKAGNFYLAREFSKRLKDDGVISVAFNPGNLRSEMQRHGSTMRKVLVHIMSHPAVYGAYTELYAGWSKDITMEKTGAWVIPWGRFGHLRDDIEKGCGNGVSAKFWAWCKAESKEFCSERAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZC93</accession>
    <name>C7ZC93_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GCN5-related N-acetyltransferase Rv2170-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_91432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698918">
        <property type="protein sequence ID" value="EEU38331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044044.1">
        <property type="nucleotide sequence ID" value="XM_003043998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZC93"/>
    <dbReference type="GeneID" id="9670369"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_91432"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_91432"/>
    <dbReference type="eggNOG" id="ENOG502SDQB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030809_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZC93"/>
    <dbReference type="OMA" id="DEMPIAW"/>
    <dbReference type="OrthoDB" id="61870at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053225">
        <property type="entry name" value="Acyl-CoA_N-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="GCN5-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20958">
        <property type="entry name" value="GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20958:SF6">
        <property type="entry name" value="GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GCN5-related N-acetyltransferase Rv2170-like" evidence="1">
        <location>
            <begin position="219"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="312" mass="34765" checksum="A4E8E2ECA7FA13FC" modified="2009-10-13" version="1">MTEYVQVYSAVPEGLLKLLDDNLPYSLPLLRRIQFTKFEGGLTKTASIILVSDHGDLEGEAPPQRFSAAYLDIGGGPDTQMWVYSTVEKPSNPDTKETIIYERQLARLVDEAIGIAKEYNKELAYPGAVLLGTVHDTTRALLAKTGRVEARETGAYDKWLFQYQDIPNDETKLPEGMNWATANEDDCAVVVSRTNIPRTVEVLGRMPSLVIKLDDGTPISWAFLGFDGSLVSLHCEEGYRRRGLAKTLAAKLFREKSRAFADDGWCSADVAPDNDGSRGMCKRLNGKPYWRISWVLLYVGEKPPEKLNGVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCG8</accession>
    <name>C7ZCG8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_77047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698918">
        <property type="protein sequence ID" value="EEU38259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043972.1">
        <property type="nucleotide sequence ID" value="XM_003043926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCG8"/>
    <dbReference type="GeneID" id="9670405"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77047"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77047"/>
    <dbReference type="HOGENOM" id="CLU_125080_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZCG8"/>
    <dbReference type="OMA" id="WHAGNAR"/>
    <dbReference type="OrthoDB" id="2989864at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025363">
        <property type="entry name" value="DUF4267"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14087">
        <property type="entry name" value="DUF4267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU38259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="129" mass="14147" checksum="FEBF90564CC0DC20" modified="2009-10-13" version="1">MFQTFRYNHIPALLVAAALCYPTIAAIFISPNAVLKGNGFPPHIASSEEAWLVDAAGNARMLCLGGLMFYFYRRGDYRVLDTFLASASTIGIVECFALWDIGNRTILVLRFIVLFVVSVLGAAQVTELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCM6</accession>
    <name>C7ZCM6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_34680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698918">
        <property type="protein sequence ID" value="EEU38394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003044107.1">
        <property type="nucleotide sequence ID" value="XM_003044061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCM6"/>
    <dbReference type="GeneID" id="9670329"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_34680"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_34680"/>
    <dbReference type="eggNOG" id="KOG1192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1809">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000537_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZCM6"/>
    <dbReference type="OMA" id="ARRILMM"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000100">
        <property type="entry name" value="Glycosyltransferase family 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF13">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="3">
        <location>
            <begin position="122"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="4">
        <location>
            <begin position="444"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="655"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="656"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="688"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU38394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="900" mass="97777" checksum="0AD1F993DB31B9AB" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZCR6</accession>
    <name>C7ZCR6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_84314</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698919">
        <property type="protein sequence ID" value="EEU37968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043681.1">
        <property type="nucleotide sequence ID" value="XM_003043635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZCR6"/>
    <dbReference type="GeneID" id="9670164"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84314"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84314"/>
    <dbReference type="eggNOG" id="ENOG502SNVB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015493_0_2_1"/>
    <dbReference type="InParanoid" id="C7ZCR6"/>
    <dbReference type="OMA" id="CEARTDI"/>
    <dbReference type="OrthoDB" id="5130013at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF39">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU37968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="56730" checksum="3A17BC435D99B873" modified="2009-10-13" version="1">MADDPVKPTGKGCGPCRGARSWHSSSQGAMSLTHPRTQVILRPHPADLPALREIEPALRRVQPAALMASPQRPKAHHSRASGPRSQAPSSYVPRPTHQLLWFPEEAVRRVPTSSFALARPVRWMPFALNTDEQSLVYYFESVASACLMVYGEDSSALLSTLIRMTLSGGSRSTVCLMQSMLAVSSLYLHGLQAQSIKYHTAALQAMRETADIGLTGVEPCEHVAAAMLLGSYEARILTQSYAQWAPYICAARDVAEKSSSNNVLRDDGDFMIILGWLHYHYVLGNFTILHWPRGISPGEWVERYDGTGAVPLDNPLADHVALVYPAGPSHKLLQYLVRALANLRSPSDPGFFTDAYQDYLKMLQRGIKEIDPVEPDEEFSLASSESTALTRIYQLAALVYIECCASNITVESSEVSEMVDEGFHLMEQLGMCNWPFPLLIFGCEARSDARRLQLLNLVSSAKRKKSGRNLRQVMSMVEFAWKQEDLGTKFISYVTRMQLLFATCGTVPIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZD45</accession>
    <name>C7ZD45_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_47977</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698919">
        <property type="protein sequence ID" value="EEU38029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043742.1">
        <property type="nucleotide sequence ID" value="XM_003043696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZD45"/>
    <dbReference type="FunCoup" id="C7ZD45">
        <property type="interactions" value="208"/>
    </dbReference>
    <dbReference type="GeneID" id="9670029"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_47977"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_47977"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZD45"/>
    <dbReference type="OMA" id="PWAIRII"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF240">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="229"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU38029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="419" mass="45233" checksum="0B8FA795B4BA16BF" modified="2009-10-13" version="1">MPHHSQPSTLISDDDQDYPEGGTRAWLVVLGAWCAMIPSMGLLNTLAVLQAWVLKNELSHLPESTIGWIFGCYGFFLYFCEYFLKMLTFIGPIVDAHDLKLVIIPGSIGMVASMIFVKFYHFLLSFGVLGGISASLLFNPSLAAVGHWFYKRRAFATGLACTAGGIGGVAFPLVILYLGPKIGFPWAIRVIALINAVSGAVACCLLRKRLPPNKKAGASIDLKALSDLKYAATTAAIFLIEFAVFIPYSYISAYALHYGFNSQKAYMLNTLLNVGAVPGRALPGYVADRFGTFNTMCITAFICAAFILTLWLTADGEEVRTTSFTILFGFWSGAAISLTPVCVSQVCKIEDYGKRNGTAFFIASFGALTGIPIAGAILEANEGSYWGLIVFAGVLYTAAFAAFVFARGVAGGWNLRMVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDF5</accession>
    <name>C7ZDF5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_97996</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043606.1">
        <property type="nucleotide sequence ID" value="XM_003043560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZDF5"/>
    <dbReference type="GeneID" id="9669436"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_97996"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_97996"/>
    <dbReference type="eggNOG" id="KOG0253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_52_4_1"/>
    <dbReference type="InParanoid" id="C7ZDF5"/>
    <dbReference type="OMA" id="LLWFIWM"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF12">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="45"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU37893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="515" mass="56091" checksum="6DD7B0F932AA1D4A" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDJ7</accession>
    <name>C7ZDJ7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_88307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043551.1">
        <property type="nucleotide sequence ID" value="XM_003043505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZDJ7"/>
    <dbReference type="STRING" id="660122.C7ZDJ7"/>
    <dbReference type="GeneID" id="9669868"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88307"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88307"/>
    <dbReference type="HOGENOM" id="CLU_1993210_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZDJ7"/>
    <dbReference type="OrthoDB" id="300709at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="19"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="125" mass="13808" checksum="1AFD2EFED9FB03A6" modified="2009-10-13" version="1">MFQEKLLNFQRDYLGKHNHRRGKAKESASSGIKVVKANSWNPKELDAAFNGCWGLWVSTNSDDINFKNEAGPPESQMGCNIIDAAIPQGINHFIFQSLSTASKITNVEVPILSSDNKEAVSRKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZDR7</accession>
    <name>C7ZDR7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase II subunit A C-terminal domain phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_54936</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This promotes the activity of RNA polymerase II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="GG698920">
        <property type="protein sequence ID" value="EEU37798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043511.1">
        <property type="nucleotide sequence ID" value="XM_003043465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZDR7"/>
    <dbReference type="FunCoup" id="C7ZDR7">
        <property type="interactions" value="816"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7ZDR7"/>
    <dbReference type="GeneID" id="9669463"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_54936"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_54936"/>
    <dbReference type="eggNOG" id="KOG0323">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007683_0_2_1"/>
    <dbReference type="InParanoid" id="C7ZDR7"/>
    <dbReference type="OMA" id="DQTVIHC"/>
    <dbReference type="OrthoDB" id="10249888at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17729">
        <property type="entry name" value="BRCT_CTDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000142">
        <property type="entry name" value="Similar to FCP1-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011947">
        <property type="entry name" value="FCP1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02250">
        <property type="entry name" value="FCP1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="9">
        <location>
            <begin position="154"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="8">
        <location>
            <begin position="490"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="334"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="447"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="589"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="635"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="598"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="635"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU37798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="765" mass="85510" checksum="6D41C85D0C3CF942" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEE3</accession>
    <name>C7ZEE3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_106522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698921">
        <property type="protein sequence ID" value="EEU37563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043276.1">
        <property type="nucleotide sequence ID" value="XM_003043230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEE3"/>
    <dbReference type="GeneID" id="9669257"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_106522"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_106522"/>
    <dbReference type="eggNOG" id="ENOG502SPJZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100997_3_2_1"/>
    <dbReference type="InParanoid" id="C7ZEE3"/>
    <dbReference type="OMA" id="PAPCVRN"/>
    <dbReference type="OrthoDB" id="2820488at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002987044" description="SnoaL-like domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU37563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="18617" checksum="C643356448B64DDE" modified="2009-10-13" version="1">MARFLTVLLTAIWLSTSSALSMPSDITARHLDQGITTRQTLVAPPPCVPINPPPSEFETKHRFSCFAHAFLVTKNLTEAFQYISEGYINHNPFVTQNGSQAAFDFLAPIWPTTNVTFHRKLFRGDMGWVNYNTPFAGDIIDRFRWEAGCIVEHWDVGEVWPTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEF8</accession>
    <name>C7ZEF8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_53569</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698921">
        <property type="protein sequence ID" value="EEU37568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043281.1">
        <property type="nucleotide sequence ID" value="XM_003043235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEF8"/>
    <dbReference type="GeneID" id="9665380"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_53569"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_53569"/>
    <dbReference type="eggNOG" id="ENOG502RF8N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015502_1_0_1"/>
    <dbReference type="InParanoid" id="C7ZEF8"/>
    <dbReference type="OMA" id="FCYRIEA"/>
    <dbReference type="OrthoDB" id="10067394at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431:SF2">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="45"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="509"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU37568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="565" mass="63278" checksum="4589AAA5D93DC3B9" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZEG2</accession>
    <name>C7ZEG2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_102125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698921">
        <property type="protein sequence ID" value="EEU37570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043283.1">
        <property type="nucleotide sequence ID" value="XM_003043237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZEG2"/>
    <dbReference type="STRING" id="660122.C7ZEG2"/>
    <dbReference type="GeneID" id="9669269"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102125"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102125"/>
    <dbReference type="eggNOG" id="ENOG502SK7Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022730_2_1_1"/>
    <dbReference type="InParanoid" id="C7ZEG2"/>
    <dbReference type="OMA" id="HIMVGSQ"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF213">
        <property type="entry name" value="DEPENDENT OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="51"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU37570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="495" mass="53502" checksum="BB61BC95D4441466" modified="2009-10-13" version="1">MSQSDFIQDAVKLITARPGLPSLNPTQAAWQEPPHPTVSNAQSPELPSETDVAIIGSGITGTAVAHYLLNHGRNLRVTILEARTAVSGATGRNGGHLVSDSDSLFPSLVKEVGIDQAVETVRFSEANIRRLKDLTALLSPEEREAVEFRNVISTTGLEDQESFEEAVDGLKQLLKAVPDSDIKYKLCNKEDASKGFGFENVAGVVEQHGVAALWPYRLITAVLASLKKDFPSRFNLETETPVVSVNHEDDTSQIFPYTLNTYRGVLRTKYVVHCTNGYSGHLIPNLVGKLYPLRGTMSTQKMGPSFPHVGDRMSWSHISKGTYDGETGHIQLGLYYAQQNAKTGVMFLGGESQSLSGLLTSDDSFVGDDARDTLTSAAPHIWKDAAPAKPLKVWSGIMGFTADGMPLVGRLPAGLTGRPGSGEWIAAGFNGHGMDKCWLSGEALARMVVGEEIVPGFPRAYLLTAQRIKSWTPEKAAETLMDHIMLGGTAPTNQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZF45</accession>
    <name>C7ZF45_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_86386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698922">
        <property type="protein sequence ID" value="EEU37503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043216.1">
        <property type="nucleotide sequence ID" value="XM_003043170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZF45"/>
    <dbReference type="STRING" id="660122.C7ZF45"/>
    <dbReference type="GeneID" id="9665222"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_86386"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_86386"/>
    <dbReference type="eggNOG" id="ENOG502SU9K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070390_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZF45"/>
    <dbReference type="OMA" id="CDSAAWI"/>
    <dbReference type="OrthoDB" id="5424430at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU37503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="27598" checksum="BF5DAE026C91FFB5" modified="2009-10-13" version="1">MSRDYSDLQVVPDQSYPEVVPQFEKDPTDKVPVEPPQQATPPKRICGLPPKRFWIIVAVIVLVTGAVIGGAIGGTQANKSKSNNDTPSSPATTEADRATIEPTKTSTSTTASLSTRTLIGPTQTLYRDCPSSNDTIYEALGSSNYLFRKRCNVGFAGSPNNVVNIPATSLDDCIDKCATYNENNKTEIASRESNVCNSVCWRHRVTGDDWPGQCFGSTIQNSTSSGFPVDEDQIECDSGAWINQEIPDEQRLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZFM4</accession>
    <name>C7ZFM4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_78418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698923">
        <property type="protein sequence ID" value="EEU37293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003043006.1">
        <property type="nucleotide sequence ID" value="XM_003042960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZFM4"/>
    <dbReference type="GeneID" id="9665120"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78418"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78418"/>
    <dbReference type="HOGENOM" id="CLU_1482377_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZFM4"/>
    <dbReference type="OrthoDB" id="5059302at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU37293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="182" mass="20252" checksum="1EAF18D55CF961B5" modified="2009-10-13" version="1">MSETSSTLPQGPPGFGNYPAVSRPWLERMVAILEARGLLSHVAWKKALEELRELLLLPEGPSAFVPLHILSVAKKACDEDFEHFGDFIHQAEANLALLVNKQRPVSGWSAQCMARMVGFEASHEDDNIEKGREVSLKGLHHMKAFFHLHQNGRVLALVGGHIEELRKFIQAKGLGAHLPSFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZGP4</accession>
    <name>C7ZGP4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_42230</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698925">
        <property type="protein sequence ID" value="EEU36949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042662.1">
        <property type="nucleotide sequence ID" value="XM_003042616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZGP4"/>
    <dbReference type="GeneID" id="9669956"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_42230"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_42230"/>
    <dbReference type="eggNOG" id="ENOG502RYRX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019101_1_1_1"/>
    <dbReference type="InParanoid" id="C7ZGP4"/>
    <dbReference type="OMA" id="WTLKFTT"/>
    <dbReference type="OrthoDB" id="5398233at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF19">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14080)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="36"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="289"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU36949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="410" mass="45726" checksum="CEA6895623C91E4D" modified="2009-10-13" version="1">MGFYTEAPDPRPFSEDKPTLLVSWWVTAFCFAVILIRMSGRYVRVEKLLKEDKIVAVALLPLVLRAVCVHFALRYGTNNVNLEGVKLTQDEIDKRIMGSRMVLASRIFYAATLWIIKFTTLEFFERLAGATRRRSHALMIIGMRVVLIATFVAVLVSDLAECQPFPHYWQVTPDPGGKCRQGFAHMITMGACNVITDLVLIAFPIPIILSTQIATKRKVLLIMLFSLGLLTVGITLYRMPRIIQAQGSQVVRTMWASVEILAATGVGNTVALGSFLRDSGVKRKKFKGSNSYEYSNSRSQSQPTKLTRTAGHSNWEEESEDGQPVKTTEGIWTGSAASHTTTGSISISKDDDLRKFSERPVSPTQSHDSLITRDQLQHSVEIGRNEFPYRPPSAIIAGNSKEVQRSQRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZH38</accession>
    <name>C7ZH38_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_51933</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698927">
        <property type="protein sequence ID" value="EEU36653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042366.1">
        <property type="nucleotide sequence ID" value="XM_003042320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZH38"/>
    <dbReference type="GeneID" id="9669697"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_51933"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_51933"/>
    <dbReference type="eggNOG" id="KOG2317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_7_3_1"/>
    <dbReference type="InParanoid" id="C7ZH38"/>
    <dbReference type="OMA" id="GGYNEVW"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF48">
        <property type="entry name" value="2-AMINOMUCONATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU36653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="148" mass="15843" checksum="5D1FD2A14D59DD74" modified="2009-10-13" version="1">MSSNGDAVILPAGSAKGLANYPHGRLIPSVDSRTLYISGTSSRLPDGSFEGFETNSDGTPSFDVGKQTAAILRNVDAVVKQATNGKGGLHNIIDVTVFLTDMDYYAGMNEVWNEFWPNYEEAPARTTIAVKALPSPKMVVEMKCTAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZHG2</accession>
    <name>C7ZHG2_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Expressed protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_100756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698928">
        <property type="protein sequence ID" value="EEU36537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003042250.1">
        <property type="nucleotide sequence ID" value="XM_003042204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZHG2"/>
    <dbReference type="GeneID" id="9669354"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100756"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100756"/>
    <dbReference type="eggNOG" id="ENOG502SXT0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117741_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZHG2"/>
    <dbReference type="OMA" id="AEPRHKR"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU36537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="145" mass="15996" checksum="78047EC463D81C16" modified="2009-10-13" version="1">MSRKRKQDEEEEELVSLPEDDDGEEEEEYISTGDEEEQSEEDEDAEEEEEDDEEGDEPEEKVEPPVKKRKTTEASGEEVPNGDAAEEEDEPEEEEEDAEAEDEEDAEADEDAADVPAPAKETIKAPEAPAATETPEPKAVTAGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKG2</accession>
    <name>C7ZKG2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">2-hydroxyacid dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_55504</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698938">
        <property type="protein sequence ID" value="EEU35556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041269.1">
        <property type="nucleotide sequence ID" value="XM_003041223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKG2"/>
    <dbReference type="STRING" id="660122.C7ZKG2"/>
    <dbReference type="GeneID" id="9675873"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55504"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55504"/>
    <dbReference type="eggNOG" id="KOG0069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_2_1"/>
    <dbReference type="InParanoid" id="C7ZKG2"/>
    <dbReference type="OMA" id="MNVLYYN"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047964">
        <property type="term" value="F:glyoxylate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009436">
        <property type="term" value="P:glyoxylate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000026">
        <property type="entry name" value="Glyoxylate/hydroxypyruvate reductase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF269">
        <property type="entry name" value="HYPOTHETICAL D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="31"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="122"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU35556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="35763" checksum="4BE77B4951ECEFDD" modified="2009-10-13" version="1">MMPLKPRILFFNPVRHALAAYEALSAVAAPEVVISKSRAEFFADLKDRYRDIRAIYRTSASGAVAGNFDKEFIDHLPSSLKYICHTGAGYDQIDIDACTQRNITVTYAPDPVTDATADLTIFLLLGAVRRLNPSLKSLREGKFKQGIEAGHDPKGKTLGILGMGRIGRAVKHRAAPFGLKVIYHNRRPLSAGLAAGCPYVSFDELLRTSDIISIHVPLSAATHHLIGEGEIAKMKPGVVIVNTARGAIVDEAAMAAALEDGHIAAVGLDVYEKEPKINEQLIKNDRAILVPHLGTHTVETLTEMESLAMENARRGVCGEELLTIVPEQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKJ7</accession>
    <name>C7ZKJ7_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_97037</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698940">
        <property type="protein sequence ID" value="EEU35418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041131.1">
        <property type="nucleotide sequence ID" value="XM_003041085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKJ7"/>
    <dbReference type="GeneID" id="9675696"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_97037"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_97037"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_4_2_1"/>
    <dbReference type="InParanoid" id="C7ZKJ7"/>
    <dbReference type="OMA" id="ICFACTI"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000386">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF15">
        <property type="entry name" value="TRANSPORTER SEO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="55"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU35418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="476" mass="52793" checksum="403104F44FC9CE17" modified="2009-10-13" version="1">MATMPIEKAPHHALTTGESEKTAAHTAAQPKWYQWFAPSDTPEERRLIMKLDGLIMVFVFLAYWAKVLDSSATSAAYVSGMKEDLKLYGNELNYLNTTYMVGFITLQIPLTVLMTRFSATYFIPGADLIWGVLTLVQYKVTNVQQLYVIRFFVGAAGSLFFPAVQWYLGCWYKRSELSRRGALFFIASQVGSMSSGYIQSGAYSSLNGRHGIEGWRWLYIICFACTVPVAVLGFVALPSHPNKCKPGLLTEREIQLARERMASEHREPPKPLTIPVIRNVLSGWHFWVLVSFAFFFSQADGVSSQSGLALWLKAEGYGVESINTITTVSPAVTIISSIICGILSDAYDAKVSLIAGTAFLNIFASIVLAIWHVPTGLKFFAFFLAGSADGIAAVIYAWANEICAGNAEERAIVISSMNTIGNTFGAWLPLFVWKTVDAPRYLIGYNWTIALDVCMVAMLFVLRSFWNRERKALPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKK5</accession>
    <name>C7ZKK5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_101973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698940">
        <property type="protein sequence ID" value="EEU35424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041137.1">
        <property type="nucleotide sequence ID" value="XM_003041091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKK5"/>
    <dbReference type="STRING" id="660122.C7ZKK5"/>
    <dbReference type="GeneID" id="9675819"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101973"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101973"/>
    <dbReference type="eggNOG" id="ENOG502QS80">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013511_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZKK5"/>
    <dbReference type="OMA" id="CIVDAFT"/>
    <dbReference type="OrthoDB" id="5339038at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046539">
        <property type="entry name" value="DUF6604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016864">
        <property type="entry name" value="UCP028035"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795:SF1">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20253">
        <property type="entry name" value="DUF6604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028035">
        <property type="entry name" value="UCP028035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6604" evidence="2">
        <location>
            <begin position="9"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU35424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="959" mass="108184" checksum="14DB358E5FD97A44" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKT3</accession>
    <name>C7ZKT3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_100780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698941">
        <property type="protein sequence ID" value="EEU35354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041067.1">
        <property type="nucleotide sequence ID" value="XM_003041021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKT3"/>
    <dbReference type="GeneID" id="9675662"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100780"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100780"/>
    <dbReference type="eggNOG" id="ENOG502SR19">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062455_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZKT3"/>
    <dbReference type="OMA" id="EGGFGEW"/>
    <dbReference type="OrthoDB" id="5420711at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="1">
        <location>
            <begin position="7"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU35354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="286" mass="32753" checksum="D2F7D83F19D78F51" modified="2009-10-13" version="1">MATEEPMLMRIPPEIRMLIYEYLLDNGGNRDIAIRNQSKCEYQARRSKCQRSAYHIVERSFAKMSYETTYCADGETDRAMHTAVMHINRKIREEASHFLYTRHAFHFGEDLEAVVPFLADKTPRTRDLVREISLYKRSPTNTVEPDSYDWSSVCRFLRDSQGLDKLTLVIEGARPRGPWDGPQNLTVSDFRLLYTTRHDSLEWARELASVKTIKEVEIVADIHHLPHPQSNMMLVLAAFSASIETSLVDFLRDDLGIPARVGKAKYCGTGSFGRSKNCQRNGCLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZKV9</accession>
    <name>C7ZKV9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_69960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698941">
        <property type="protein sequence ID" value="EEU35367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003041080.1">
        <property type="nucleotide sequence ID" value="XM_003041034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZKV9"/>
    <dbReference type="GeneID" id="9675565"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_69960"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_69960"/>
    <dbReference type="eggNOG" id="KOG0013">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054816_2_0_1"/>
    <dbReference type="InParanoid" id="C7ZKV9"/>
    <dbReference type="OMA" id="GCMGRYL"/>
    <dbReference type="OrthoDB" id="1640476at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.225.20">
        <property type="entry name" value="Ub domain-containing protein, DC-UbP/UBTD2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032752">
        <property type="entry name" value="DC-UbP/UBTD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038169">
        <property type="entry name" value="DC-UbP/UBTD2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039869">
        <property type="entry name" value="UBTD1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13609">
        <property type="entry name" value="UBIQUITIN DOMAIN CONTAINING 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16455">
        <property type="entry name" value="UBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="222"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU35367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="299" mass="33376" checksum="A996FF5AC16EEEE3" modified="2009-10-13" version="1">MGCCFSRSSGPNSPYPGGAPNASSRAINPPPLALPEPVNGPVPQIPAERRRRRRHDRPLDQHIDKPLRRHEWISRDRTWTRRKLDQERADFFDTRVTGRPEIWQTVHAALKVLWDPASQDAQDDGTNGLATAQMILSAAEISLPTGNLANGVYDALGNYYQLPEWIVCDPRNVQEDGQEGAKGDASTVGDDTAADDDDLSDDDDEIEGRKREKGKEVIDVREQVILRARLSENGRDIKVRITETESVRSVAKKIAQEADLAPTKKIRIAYLGKILKENSSLSAQNWQTGHMVNALVFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZL42</accession>
    <name>C7ZL42_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ferric oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_88054</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698943">
        <property type="protein sequence ID" value="EEU35249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040962.1">
        <property type="nucleotide sequence ID" value="XM_003040916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZL42"/>
    <dbReference type="GeneID" id="9675357"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_88054"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_88054"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010365_2_0_1"/>
    <dbReference type="InParanoid" id="C7ZL42"/>
    <dbReference type="OMA" id="CFAYFPT"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988932" description="Ferric oxidoreductase domain-containing protein" evidence="9">
        <location>
            <begin position="22"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="10">
        <location>
            <begin position="280"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="490"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="491"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU35249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="722" mass="80388" checksum="CD3CE2ED17B31E2D" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZME8</accession>
    <name>C7ZME8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_55105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698951">
        <property type="protein sequence ID" value="EEU34843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040556.1">
        <property type="nucleotide sequence ID" value="XM_003040510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZME8"/>
    <dbReference type="STRING" id="660122.C7ZME8"/>
    <dbReference type="GeneID" id="9678950"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_55105"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_55105"/>
    <dbReference type="eggNOG" id="ENOG502SQDU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2533672_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZME8"/>
    <dbReference type="OMA" id="RCEDREW"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="8"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="84" mass="9662" checksum="58496DCBBBAB598F" modified="2009-10-13" version="1" fragment="single">YYNTAALSDVLVVCDDQEFQVHRVILSAHSKYFTAELNGSWKESSDRKIQIKDFDVSVVEAMLRFMYSFDYSNNTGSSIMVYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZMT1</accession>
    <name>C7ZMT1_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_82356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698958">
        <property type="protein sequence ID" value="EEU34690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040403.1">
        <property type="nucleotide sequence ID" value="XM_003040357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZMT1"/>
    <dbReference type="GeneID" id="9678816"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82356"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82356"/>
    <dbReference type="eggNOG" id="ENOG502SEAR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_762933_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZMT1"/>
    <dbReference type="OMA" id="CHEIENG"/>
    <dbReference type="OrthoDB" id="5053672at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU34690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="409" mass="46379" checksum="5AE520DCE29E5FDE" modified="2009-10-13" version="1">MPESSDYPKRPVLIDIETGFTFSAGRFKVTNGNVIRIKGSRLRALFNPASLPQRHEREKAEKAAEVLSNKAFVAGQLKHYGIKFPSTAKLGAIRDILRRAVDQGKCDRVPPFLRRVEETMRRDIEILDAEWETKIETWRENRFAAAGERAQNDINDFLDLYFLTNGYPDPSKTPAPLALCGYRDLHTIYVEAGKVPGLSLVSGGSANNQVLCVGWNYLAVSKLASTFGKTNQTDKNPQQENYCEDDTYDQHYDAVSGQNLANVSKPLDLEQLFGSYVIQFDGISEKWHMVDVFTLDIGELNDGVLMAAYDFGDVYGTMIMTPGRLFYLIRGRARGEDVIFYDPERGHIDILDDECTKLSGMAKTLADMGSDLDFWAHKVADEPNKHVRAWGDFSEKAYEFESRDRWRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNI6</accession>
    <name>C7ZNI6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_97473</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698968">
        <property type="protein sequence ID" value="EEU34431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003040144.1">
        <property type="nucleotide sequence ID" value="XM_003040098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNI6"/>
    <dbReference type="GeneID" id="9677967"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_97473"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_97473"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_8_1"/>
    <dbReference type="InParanoid" id="C7ZNI6"/>
    <dbReference type="OMA" id="MWAVGIN"/>
    <dbReference type="OrthoDB" id="2533084at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF22">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="78"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU34431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="524" mass="57802" checksum="6CC7A711248711DC" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNJ4</accession>
    <name>C7ZNJ4_FUSV7</name>
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        <recommendedName>
            <fullName evidence="5">Pyruvate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">NECHADRAFT_82254</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + H(+) = an aldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:11628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="EC" id="4.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="GG698969">
        <property type="protein sequence ID" value="EEU34407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003040074.1"/>
    </dbReference>
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    <dbReference type="STRING" id="660122.C7ZNJ4"/>
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    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82254"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:pyruvate decarboxylase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF11">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="15">
        <location>
            <begin position="7"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="13">
        <location>
            <begin position="199"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="14">
        <location>
            <begin position="406"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEU34407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="581" mass="63552" checksum="4419D60428A44A71" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNR3</accession>
    <name>C7ZNR3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_85480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039748.1">
        <property type="nucleotide sequence ID" value="XM_003039702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNR3"/>
    <dbReference type="GeneID" id="9677588"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_85480"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_85480"/>
    <dbReference type="eggNOG" id="ENOG502R6PA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1107415_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZNR3"/>
    <dbReference type="OrthoDB" id="5403707at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002987268" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="27587" checksum="20B26550295DE42D" modified="2009-10-13" version="1">MKASAAYLLTFVLGAVQAQNSVQCVDGHREMIGPDYMVEYKCGIVRQGDVHNNIATQQECAELCKNAGRSVCTYHPPTRRCVVGQEGGKEVPRPGSIYMQKVEEDVYDPFTEEQDPFGNSECDDEKAACLLRESNLQAELTKANAEAEDSKDLFASSCPVQHTKYTTVGGREYRIWCARYHDTSAPKETYNNVDTMAACIKLCSSKSWCTYALHGIFLTKCQLYERKVAHTTTPGLSNHMWNCAVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNT6</accession>
    <name>C7ZNT6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_28122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039964.1">
        <property type="nucleotide sequence ID" value="XM_003039918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNT6"/>
    <dbReference type="STRING" id="660122.C7ZNT6"/>
    <dbReference type="GeneID" id="9677899"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_28122"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_28122"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_138_0_1"/>
    <dbReference type="InParanoid" id="C7ZNT6"/>
    <dbReference type="OMA" id="QENWSEV"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="22"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU34251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="249" mass="28969" checksum="37C5ED794EABEB3E" modified="2009-10-13" version="1" fragment="single">MRLINANTLLLHEFHGENIPPYAILSHTWGDQEVTFQDWKDPRTHTAATKSGFTKVQCACQQAVIRGLEWMWVDTNCIDKTSSAELSEAINSMFAYYQKSKVCFAYLSDVPSAKGLDKKSLLWQIRNSRWFTRGWTLQELIAPEHLTFYAADWTRIGRKDEWLADLITEVTGIDRIYLNGRRQVNRACIAKRMSWLAKRTTTRVEDMAYCVLGIFDINMPLLYGEGRKAFTRLQEEIIKKTNDHTIFCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZNV0</accession>
    <name>C7ZNV0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_96633</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698970">
        <property type="protein sequence ID" value="EEU34259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039972.1">
        <property type="nucleotide sequence ID" value="XM_003039926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZNV0"/>
    <dbReference type="GeneID" id="9677697"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_96633"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_96633"/>
    <dbReference type="eggNOG" id="KOG0819">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025300_4_3_1"/>
    <dbReference type="InParanoid" id="C7ZNV0"/>
    <dbReference type="OMA" id="DYNSRFM"/>
    <dbReference type="OrthoDB" id="37886at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF102">
        <property type="entry name" value="ANNEXIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0041">Annexin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU34259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="47909" checksum="81E3975083F63B32" modified="2009-10-13" version="1">MSGQPPYWQAPQGQQQQGQQQQGYPAQQPYGYAPQGQQPNQPYPYATPQQSYPQQGQPPNQSYYSDPSQQQYPQQGQPGQYQQPPQGQPARPISAAPPGIPEKASLGYDPQQKLETMAVDKAADVEAVRKAMKGMGCDERTLIRVLTNSKYRNPWAMAQFVEAYNSRFLRDLAKDIESETKGSLETGLLALIRGPLANDVYVLSKALNRLGTDEEALNDVLLCRSNADIRAIAAEYKRTRGKELLSDIKDDVDDTLFRLYSMVLAGTRLEGITAIDPVEIDQKVTELQNATEGQIGANAIVVAQIFTSSSDLQLRAISDAYQHKYRRRLKDVIEKEFRGDLEDALLLMLDHATDPALFVASKLNRPLKSSRKEKHFINRLLALYWRPNGIQLARTGYETYFRVSLRSDIKAGLDGDFEQLALALIGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZR16</accession>
    <name>C7ZR16_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="5 14">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">NECHADRAFT_105766</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="14">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="5 14"/>
    <dbReference type="EMBL" id="GG699024">
        <property type="protein sequence ID" value="EEU33541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039254.1">
        <property type="nucleotide sequence ID" value="XM_003039208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZR16"/>
    <dbReference type="STRING" id="660122.C7ZR16"/>
    <dbReference type="GeneID" id="9666773"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_105766"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_105766"/>
    <dbReference type="eggNOG" id="KOG0441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056632_4_1_1"/>
    <dbReference type="InParanoid" id="C7ZR16"/>
    <dbReference type="OMA" id="CGTIWIK"/>
    <dbReference type="OrthoDB" id="2015551at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000001">
        <property type="entry name" value="Superoxide dismutase [Cu-Zn]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00087">
        <property type="entry name" value="SOD_CU_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="12 14" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="15">
        <location>
            <begin position="15"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEU33541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="173" mass="18289" checksum="95B938FAA9FFC17D" modified="2009-10-13" version="1">MVKAIATVRGDSTVFGTITFEQLDESSPTTISWNLRGNDANSQRAFHIHEFGDNTNGCTSAGPHFNPFGRTHGAPSHNERHVGDLGNFQTDSSGTSIGTMTDHLVKLIGPESVLGRTIVIHAGTDDLGQGPNEESKITGNAGGRPACGVIGISSSGFQCRYEPVTHSLFGHDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C7ZR92</accession>
    <name>C7ZR92_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_89462</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG699047">
        <property type="protein sequence ID" value="EEU33465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003039178.1">
        <property type="nucleotide sequence ID" value="XM_003039132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7ZR92"/>
    <dbReference type="GeneID" id="9666700"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_89462"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_89462"/>
    <dbReference type="eggNOG" id="ENOG502SB6N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1722849_0_0_1"/>
    <dbReference type="InParanoid" id="C7ZR92"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF16">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU33465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="152" mass="17430" checksum="14FC49739CFEB302" modified="2009-10-13" version="1">MGQKAIGHNDLFIPSPHNPVPYKEPFEWDEKVYYYEKTLGMITLKLCLALPAKSILACALTSISLTRNDRGDGETLTLEDTAEHYHRRHNDSKATNPNFRFGNNGAICSLAQYANMFGMLGRYGKNGPGTLHVEDVKKFYLDEDWPKDYWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7YGX1</accession>
    <name>C7YGX1_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_98785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU47817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053530.1">
        <property type="nucleotide sequence ID" value="XM_003053484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YGX1"/>
    <dbReference type="STRING" id="660122.C7YGX1"/>
    <dbReference type="GeneID" id="9676862"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_98785"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98785"/>
    <dbReference type="eggNOG" id="ENOG502RJIP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016098_0_0_1"/>
    <dbReference type="InParanoid" id="C7YGX1"/>
    <dbReference type="OMA" id="QSMTRKK"/>
    <dbReference type="OrthoDB" id="37886at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU47817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="746" mass="80908" checksum="94ADF3C3F3D5257D" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>C7YI27</accession>
    <name>C7YI27_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">NECHADRAFT_75173</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cyclophilin-type PPIase family. CWC27 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053732.1">
        <property type="nucleotide sequence ID" value="XM_003053686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YI27"/>
    <dbReference type="STRING" id="660122.C7YI27"/>
    <dbReference type="GeneID" id="9664414"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_75173"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_75173"/>
    <dbReference type="eggNOG" id="KOG0885">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_14_5_1"/>
    <dbReference type="InParanoid" id="C7YI27"/>
    <dbReference type="OMA" id="CKNFLQH"/>
    <dbReference type="OrthoDB" id="442970at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01925">
        <property type="entry name" value="cyclophilin_CeCYP16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000034">
        <property type="entry name" value="Peptidyl-prolyl isomerase CWC27 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF6">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="8" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="16">
        <location>
            <begin position="18"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="204"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="258"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="499"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="296"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="499"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="530"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEU48019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="545" mass="60993" checksum="B80B1CCF80627114" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIR8</accession>
    <name>C7YIR8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_90419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054566.1">
        <property type="nucleotide sequence ID" value="XM_003054520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIR8"/>
    <dbReference type="ESTHER" id="nech7-c7yir8">
        <property type="family name" value="PMH_Peptidase_S9"/>
    </dbReference>
    <dbReference type="GeneID" id="9664688"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_90419"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_90419"/>
    <dbReference type="eggNOG" id="KOG2100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012236_1_0_1"/>
    <dbReference type="InParanoid" id="C7YIR8"/>
    <dbReference type="OMA" id="HKLESRY"/>
    <dbReference type="OrthoDB" id="43744at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF5">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="2">
        <location>
            <begin position="436"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU48853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="646" mass="70961" checksum="040BF3202449AF37" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C7YIZ4</accession>
    <name>C7YIZ4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">GPI mannosyltransferase 1</fullName>
            <ecNumber evidence="13">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">GPI mannosyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NECHADRAFT_65925</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Required for cell wall integrity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the PIGM family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="13"/>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054606.1">
        <property type="nucleotide sequence ID" value="XM_003054560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YIZ4"/>
    <dbReference type="FunCoup" id="C7YIZ4">
        <property type="interactions" value="609"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YIZ4"/>
    <dbReference type="GeneID" id="9663674"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_65925"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_65925"/>
    <dbReference type="eggNOG" id="KOG3893">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024220_1_0_1"/>
    <dbReference type="InParanoid" id="C7YIZ4"/>
    <dbReference type="OMA" id="LINCWIL"/>
    <dbReference type="OrthoDB" id="1741594at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051751">
        <property type="term" value="F:alpha-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007704">
        <property type="entry name" value="PIG-M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886:SF0">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886">
        <property type="entry name" value="PIG-M MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05007">
        <property type="entry name" value="Mannosyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 13" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEU48893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="424" mass="47652" checksum="52840FCF9EC851A3" modified="2009-10-13" version="1">MPSITPLLRTTPLFFISLLLRLILLFYGLYQDAHSALKYTDIDYLVFTDASRFLASGSSPYDRDTYRYTPLLAWLLLPTVRFSAFGKLVFAAADLLAGWLMLRVLRRRGMDEATAGGFAALWLWNPMVATISTRGSSEGLLGVLTMSLLWAVERRKISLAAVILGLSVHFKIYPFIYAPAIIWWMDDERLGKPTKATSKPSFLVDTLTKFCSPERAKLALISFATFMGFNLLMYSIYGTPFLVHTYFHHVSRIDHRHNFSPYNVLLYLTSATPADATPSIRIESLAFLPQLLLSCVLIPLALAKRDLATSMMAQTFAFVTFNKVCTSQYFLWYMVFLPLYLPNSSFLRNPKLGISALLLWVVSQAAWLQNGYQLEFLGVSTFFPGLWLSSLGFFLVNCWILGIIISDGADVPQSAASSVKAHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7YKJ8</accession>
    <name>C7YKJ8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_74635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698896">
        <property type="protein sequence ID" value="EEU48464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003054177.1">
        <property type="nucleotide sequence ID" value="XM_003054131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YKJ8"/>
    <dbReference type="FunCoup" id="C7YKJ8">
        <property type="interactions" value="767"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YKJ8"/>
    <dbReference type="GeneID" id="9676796"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_74635"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_74635"/>
    <dbReference type="eggNOG" id="KOG4018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084528_0_1_1"/>
    <dbReference type="InParanoid" id="C7YKJ8"/>
    <dbReference type="OMA" id="QWDEHKK"/>
    <dbReference type="OrthoDB" id="277175at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23823">
        <property type="entry name" value="RWD_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000075">
        <property type="entry name" value="RWD domain-containing protein (Gir2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040213">
        <property type="entry name" value="GIR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12292">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="1">
        <location>
            <begin position="8"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU48464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="228" mass="26392" checksum="13B6CDB6B37F7E42" modified="2009-10-13" version="1">MGREDQIEEREVLESIFPDEITDISETEFRVSIALDILDEEDEEPPTMLLQVRYPDEYPEKPPHLDILAPPNATPHEHFNVADDRDQLLSSLEETIQENLGMAMIFTIVSMLKETAEQLVQDRKAVVEKAHEDALLAAEAEENKKFHGTAVTPESFLKWREGFLKEMEERRQREEDERLQELKKARVKEPTRLTGKQLWERGLVGKVEGEEEDDDMPIEAVEKLKVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C7YLL0</accession>
    <name>C7YLL0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper-fist domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_67124</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052999.1">
        <property type="nucleotide sequence ID" value="XM_003052953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YLL0"/>
    <dbReference type="GeneID" id="9671043"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_67124"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_67124"/>
    <dbReference type="eggNOG" id="ENOG502S7CA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022327_1_0_1"/>
    <dbReference type="InParanoid" id="C7YLL0"/>
    <dbReference type="OMA" id="AHIKCDC"/>
    <dbReference type="OrthoDB" id="5600085at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.430.10:FF:000001">
        <property type="entry name" value="Copper fist DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00617">
        <property type="entry name" value="COPPERFIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="100"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU47286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="426" mass="45949" checksum="A8AD760ED6F3BF98" modified="2009-10-13" version="1">MIIDGEKYACEACVRGHRVSNCQHSDRPLQHINKKGRPVSQCAHCRAMRKSRSAHVKCDCGEKTSKCAHLQPTVEGHTETCCCNHGGRCSCSLKKEPALDTVPESDSERESLTMSASGRPKPPGRRRRANTVHSDGVLTFDQNGHHKPAHRGSRVSQKCGPYQLNRVNSAHSTGSLGTDSMLKGTREPPTSRARAASTREQRRVKSETASPLMSGATGFQTLNGNLPPLDLSGIEYPPYMANSTFDLFGSGFNSEADAPMYSAGLSATSVDWSHYDLTDMKGDSFTPSSYSQAGTQSFNGLFDFGSGSEQLPHLANTTSTSGEVSEVEDFLPGGEGDFDGLDGFGRGNSFMRQSGSLMTSSADLSSIDYDSFYKGADSGPMAGAGLSMVEDDPAFWMPNYNERSITAMDESPDHVGPSSMPTFWDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7YM64</accession>
    <name>C7YM64_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein-sorting-associated protein 25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NECHADRAFT_67376</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS25 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053112.1">
        <property type="nucleotide sequence ID" value="XM_003053066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YM64"/>
    <dbReference type="FunCoup" id="C7YM64">
        <property type="interactions" value="816"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YM64"/>
    <dbReference type="GeneID" id="9671134"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_67376"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_67376"/>
    <dbReference type="eggNOG" id="KOG4068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087657_0_1_1"/>
    <dbReference type="InParanoid" id="C7YM64"/>
    <dbReference type="OMA" id="TRCLIMW"/>
    <dbReference type="OrthoDB" id="245150at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.570:FF:000003">
        <property type="entry name" value="Vacuolar protein-sorting-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.570">
        <property type="entry name" value="Winged helix' DNA-binding domain. Chain C. Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008570">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014041">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05871">
        <property type="entry name" value="ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEU47399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="202" mass="23028" checksum="151B9F230DC508D3" modified="2009-10-13" version="1">MATTTTDDDGSFVFPREYNFPAFFTRQTNLTTLHAQRTKWSDLILSYARHNRIFRLSLSEAADSDLFVNRKLDRRLQFDDVRDVVVFMHKDGRVEYVGGGTTGDVVLVYWRKPDEWAELIENYVDETGQKGSVLTIYELVEGDGTKGTGRFTRNKHGQSHCSPIVDIHGMDQDVLIKALNVLVKRGKAQIFGQDDSLGVKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7YM73</accession>
    <name>C7YM73_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_77781</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053116.1">
        <property type="nucleotide sequence ID" value="XM_003053070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YM73"/>
    <dbReference type="GeneID" id="9671139"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77781"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77781"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_7_2_1"/>
    <dbReference type="InParanoid" id="C7YM73"/>
    <dbReference type="OMA" id="NYPWIHI"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="509"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="553"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="16"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU47403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="574" mass="62864" checksum="59D3DE3E1F0AFFDC" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C7YMB4</accession>
    <name>C7YMB4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_77822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU46917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052630.1">
        <property type="nucleotide sequence ID" value="XM_003052584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YMB4"/>
    <dbReference type="GeneID" id="9671162"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77822"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77822"/>
    <dbReference type="HOGENOM" id="CLU_1267197_0_0_1"/>
    <dbReference type="InParanoid" id="C7YMB4"/>
    <dbReference type="OrthoDB" id="4979898at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU46917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="218" mass="24648" checksum="3A5417DE4588B6CB" modified="2009-10-13" version="1">MCHKTMAIFTVCAHSQKVPTIKCDMAQWWKPMLYKDPCIVTRFAELTRGWCPECEAVFQANAVNSGVAKDFDPRSAEFISRYWAYKSQAGWVGPVDATRFPNDLVERKDEIVCNTLGDTRYEIYALRREIEVYRADRICIEKLSCVAPGPADFPAIIDKARRLTLEWGLLGEMDEPSFPKLSSFPPKSKAVDMAKQDQKGKASEQVAQCEVCNGSHPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C7YMB8</accession>
    <name>C7YMB8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_77826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003053135.1">
        <property type="nucleotide sequence ID" value="XM_003053089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YMB8"/>
    <dbReference type="GeneID" id="9671165"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_77826"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_77826"/>
    <dbReference type="eggNOG" id="ENOG502T65R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132180_0_0_1"/>
    <dbReference type="InParanoid" id="C7YMB8"/>
    <dbReference type="OMA" id="FWRVLHA"/>
    <dbReference type="OrthoDB" id="5131008at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU47422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="156" mass="17715" checksum="DCBC605D68A814CE" modified="2009-10-13" version="1">MSEWPERDIDKIAKGWSIAMRCSKERLKRVYGLETQQLDDAVNQGRVVLETVCVFMHACVKRGQYKLPLEFWRILHSEYGIIVYPSAFSEDIEIQGLGMDVTFTEAYHGHIVMFGSCCSSHSPPPCPFEILTEPPPVYQKETPKVEAPKLDAPKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNA0</accession>
    <name>C7YNA0_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycoside hydrolase 131 catalytic N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_67676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052800.1">
        <property type="nucleotide sequence ID" value="XM_003052754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNA0"/>
    <dbReference type="GeneID" id="9671332"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_67676"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_67676"/>
    <dbReference type="eggNOG" id="ENOG502SHCH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063723_0_0_1"/>
    <dbReference type="InParanoid" id="C7YNA0"/>
    <dbReference type="OMA" id="THEYLNV"/>
    <dbReference type="OrthoDB" id="5283326at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041524">
        <property type="entry name" value="GH131_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612">
        <property type="entry name" value="GH131_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612:SF4">
        <property type="entry name" value="GLYCOSIDE HYDROLASE 131 CATALYTIC N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18271">
        <property type="entry name" value="GH131_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002987432" description="Glycoside hydrolase 131 catalytic N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase 131 catalytic N-terminal" evidence="2">
        <location>
            <begin position="35"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU47087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="294" mass="32647" checksum="F43C7A4131D047A1" modified="2009-10-13" version="1">MRAAAFFALVSSVVSATPLGHRFHTYSKASNSCAVVFDGRVPANASLTDFDTENGGGWNPFNPGYVKGNNISWSEILLLPKNTPRSRFDAVSRTVPLKVTISDESIFMQQHGFRRAGLQFAKDDNEKSPASEGVKTLHFSILQDESRPLNLSHEYLNVWHEAGDYSSNQFNFEAGTIIGQDLPKDTWKLLDRTNKQIWSTPILKDVWQNFAITLDFDNNTIQAWYSEGRKPLRAVTEPISNDNSGRGQYQIGILKKPTGTDDVVNSGFQESDLDEGLIYGGIFIEDSKDGCVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNA8</accession>
    <name>C7YNA8_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_78164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698897">
        <property type="protein sequence ID" value="EEU47093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052806.1">
        <property type="nucleotide sequence ID" value="XM_003052760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNA8"/>
    <dbReference type="STRING" id="660122.C7YNA8"/>
    <dbReference type="GeneID" id="9664368"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_78164"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_78164"/>
    <dbReference type="eggNOG" id="ENOG502SUGA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022835_1_0_1"/>
    <dbReference type="InParanoid" id="C7YNA8"/>
    <dbReference type="OMA" id="RATFDYD"/>
    <dbReference type="OrthoDB" id="5419928at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU47093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="606" mass="69711" checksum="7DEE6373A0288098" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNN6</accession>
    <name>C7YNN6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="10">1.3.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">NECHADRAFT_38826</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.88" evidence="10"/>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051863.1">
        <property type="nucleotide sequence ID" value="XM_003051817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNN6"/>
    <dbReference type="FunCoup" id="C7YNN6">
        <property type="interactions" value="664"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YNN6"/>
    <dbReference type="GeneID" id="9672942"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_38826"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_38826"/>
    <dbReference type="eggNOG" id="KOG2335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013299_5_1_1"/>
    <dbReference type="InParanoid" id="C7YNN6"/>
    <dbReference type="OMA" id="RPWWICQ"/>
    <dbReference type="OrthoDB" id="272303at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102262">
        <property type="term" value="F:tRNA-dihydrouridine16 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102263">
        <property type="term" value="F:tRNA-dihydrouridine17 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="19">
        <location>
            <begin position="33"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="316"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="421"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="474"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EEU46150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="509" mass="56797" checksum="11ECF5C06C49AC48" modified="2009-10-13" version="1">MTTGDKSPAGQQRPAKLHGRAFYESIGSPKFIVAPMVDQSEFAWRMLTRSFLSPTEQSSLLAYTPMLHARLFSQDEKYRQAHFQAVRSNEDPWLDGNPSIDRPLFVQFCANDPDALLAAAKQVAPYCDAVDLNLGCPQGIARKGKYGAFLQEDQDLIFRLINILHKELPVPVTAKIRILETEEQTLAYAQNVLKAGASILTVHGRRREQKGHLTGLAEWKMIKFLRDSLPKETVIFANGNILQEGDIERCLEATGADGVMSAEGNLSDPAIFSKPPPVGEEGREYWRDKDGKGGYRVDAVMRRYMNILHEHTLGGKAPERRPLFMPGDDTTWMTEGQAEGDEPAPKRRKKEGGGGKKGEQGPNMSAMQPHLFHLLRHFVSKHTDVRDMLAKSRAGDMDAYERVLAAVELKVAEGLLEYERTNGENVADPTPLAEGEVDPPEDESSVGTQRRCRRPWWVVQPIIRPLPNEALKKGAITLSKKEKGKAKEKKEEEKGKQEDIKARDEALAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C7YNT4</accession>
    <name>C7YNT4_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_79417</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051885.1">
        <property type="nucleotide sequence ID" value="XM_003051839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YNT4"/>
    <dbReference type="FunCoup" id="C7YNT4">
        <property type="interactions" value="670"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YNT4"/>
    <dbReference type="GeneID" id="9670866"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_79417"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_79417"/>
    <dbReference type="eggNOG" id="KOG3405">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112527_0_2_1"/>
    <dbReference type="InParanoid" id="C7YNT4"/>
    <dbReference type="OMA" id="ADYWDPE"/>
    <dbReference type="OrthoDB" id="259769at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020708">
        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01111">
        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU46172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="161" mass="18274" checksum="358F41F6DCE63D14" modified="2009-10-13" version="1">MSDFGDDDVGGAGGDEPMYEDEEVTEYYDPEVVEEDEDGENRPQDGEDMDNVVVSGDPSAAANALKGGEKLLKDKKIPEGERTTTPYMTKYERARILGTRALQIRFAFLERDASRPGWLTGETDPLQIAIKEMREKKIPLIVRRYLPDGYYEDWTCEELLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7YPF5</accession>
    <name>C7YPF5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SART-1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_92512</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNU66/SART1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052002.1">
        <property type="nucleotide sequence ID" value="XM_003051956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YPF5"/>
    <dbReference type="FunCoup" id="C7YPF5">
        <property type="interactions" value="808"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YPF5"/>
    <dbReference type="GeneID" id="9668626"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_92512"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_92512"/>
    <dbReference type="eggNOG" id="KOG2217">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009379_2_0_1"/>
    <dbReference type="InParanoid" id="C7YPF5"/>
    <dbReference type="OMA" id="KRRDYTG"/>
    <dbReference type="OrthoDB" id="5583at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000481">
        <property type="term" value="P:maturation of 5S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045347">
        <property type="entry name" value="HIND"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005011">
        <property type="entry name" value="SNU66/SART1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152">
        <property type="entry name" value="SQUAMOUS CELL CARCINOMA ANTIGEN RECOGNISED BY CYTOTOXIC T LYMPHOCYTES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152:SF5">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19252">
        <property type="entry name" value="HIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03343">
        <property type="entry name" value="SART-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="15"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="266"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="360"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="514"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="591"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="55"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="288"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="381"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="514"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="591"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="602"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="623"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU46289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="650" mass="72804" checksum="4F055899B5D43AEC" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQJ3</accession>
    <name>C7YQJ3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NECHADRAFT_100111</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051747.1">
        <property type="nucleotide sequence ID" value="XM_003051701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQJ3"/>
    <dbReference type="GeneID" id="9672660"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100111"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100111"/>
    <dbReference type="eggNOG" id="KOG3071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017661_2_0_1"/>
    <dbReference type="InParanoid" id="C7YQJ3"/>
    <dbReference type="OMA" id="WNQGLAY"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF169">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="452"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEU46034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="476" mass="51625" checksum="D2E985CF4823707C" modified="2009-10-13" version="1">MAEYLHLIGSAPDSSLFSFPPTNAPAPIPPVDVATSILRPFNIPGHIYTAALDAKVPLTIATLYAVTVKSLNIYNKSHGKKAWAISKTGPFRVFVVLHNIFLAVYSAWTFWGMLGGMRRSILNPTGPQGLAGTADSFCRLHGSQGLGNSVYYNETSSTFVTISEHAPIVNGLPSGTEAGRLWNEGLAYYGWIFYLSKFYEVLDTFIILAKGKLSSTLQTYHHAGAMMCMWAGMRYMSAPIWMFVLVNSFIHSLMYFYYTLTAFSIRVPTPIKRTLTSMQITQFLVGASYAMAHSFVSYTVPITITRTQTHGDAATATSSDSTLETVAASAIESLRQFIWGAAEAAGGEPVVSQAAGAHSTVTTETRYITQPCVTTTGETFAIWLNVLYLAPLTYLFVSFFIASYVKRSNAAGKISRKGAAPDVNANVALAEKAGWDAAKGLEKEIYNGESMVNGSSDEASRASTPKKSNGKSRRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQK8</accession>
    <name>C7YQK8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_92774</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003052198.1">
        <property type="nucleotide sequence ID" value="XM_003052152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQK8"/>
    <dbReference type="GeneID" id="9672669"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_92774"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_92774"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_2_1"/>
    <dbReference type="InParanoid" id="C7YQK8"/>
    <dbReference type="OMA" id="MRKLHIV"/>
    <dbReference type="OrthoDB" id="5141738at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF74">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="53"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU46485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="494" mass="53984" checksum="2617C934D1020DF5" modified="2009-10-13" version="1">MGSDETRCFGDDATRNHTVVDIEERGDSSDESSWSDSESWDATKLSSMRKLHIIVAGFTCTFNGNFGSSMPSGALDAIAEQFNVTNPVHLILLNSLYMVGYVLGPLLFGPLSEYIGRRPVLIGTYLGYLVFMLASSGAPNYAALLIFRLLCGINAAAPTTVIGGLYSDILDNPSVRGNAMALYMGITTLGPLVGPIVSGFSSPISWRWPFWIAGMMAASGLPLVLTLPETYAPVLQNKVALKQLKKNRKSGEGQVPELKPFDVRKIFLRPMKLLFTEPILASTSAYLTLVYAVFYLMFQAYPRVFQGFYELSPGMAGLAFLPLAVGSILSLVVFYIFTWYHDSQTKAGAEWTKNHIYRRLPLACIASPCMVISLFWLGWTVWPSVNPIIPSLGGLFFGLGFQLLFMGMINYLTDVFLQYSASALAAASMTRSIGAILLPLAADSMYADLGLHWAPSVLAFIALAMGVIPFVFIRYGDRLARSSKTARAAFAIQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7YQY2</accession>
    <name>C7YQY2_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Inositol-pentakisphosphate 2-kinase</fullName>
            <ecNumber evidence="3 9">2.7.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_68556</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has kinase activity and phosphorylates inositol-1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20313"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.158"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="9">The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IPK1 type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.158" evidence="3 9"/>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051812.1">
        <property type="nucleotide sequence ID" value="XM_003051766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YQY2"/>
    <dbReference type="FunCoup" id="C7YQY2">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YQY2"/>
    <dbReference type="GeneID" id="9673719"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_68556"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_68556"/>
    <dbReference type="eggNOG" id="ENOG502S7VH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031304_1_0_1"/>
    <dbReference type="InParanoid" id="C7YQY2"/>
    <dbReference type="OMA" id="DCTMFIR"/>
    <dbReference type="OrthoDB" id="272370at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035299">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009286">
        <property type="entry name" value="Ins_P5_2-kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456:SF2">
        <property type="entry name" value="INOSITOL-PENTAKISPHOSPHATE 2-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06090">
        <property type="entry name" value="Ins_P5_2-kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="454"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="514"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU46099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="526" mass="59709" checksum="FD095C45B684EB72" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C7YR31</accession>
    <name>C7YR31_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_37665</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an important role in cellulose degradation. Shows hydrolytic activity against several glycosidic compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="GG698898">
        <property type="protein sequence ID" value="EEU46128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051841.1">
        <property type="nucleotide sequence ID" value="XM_003051795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YR31"/>
    <dbReference type="SMR" id="C7YR31"/>
    <dbReference type="STRING" id="660122.C7YR31"/>
    <dbReference type="GeneID" id="9672829"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_37665"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_37665"/>
    <dbReference type="eggNOG" id="KOG0626">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001859_1_2_1"/>
    <dbReference type="InParanoid" id="C7YR31"/>
    <dbReference type="OMA" id="HGSNDFY"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080079">
        <property type="term" value="F:cellobiose glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000011">
        <property type="entry name" value="Cytosolic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU46128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="483" mass="55016" checksum="623754C02AC9AC79" modified="2009-10-13" version="1">MSLPADFKWGFATASYQIEGSIHKDGRGVANWDVFCDKPGKIADGSSGVTACDSYNRTAEDIALLKSVGAKAYRFSICWSRIIPLGGRNDPINQAGIDHYRKFVDDLLDAGITPFITLFHWDVPHELDVRYGGLLNRTEFPLDYERYARVMFENIPRCKNWITHNEPWCSSILGYSTGSNAPGRCSDRTKSDVGDSSREPWIVGHNLLVAHGRAVKVYREEFKPKNGGEIGITLNGDATFPWDPKDPRDVEAATRKIEFAISWFADPIYLGDYPASMRAQLGDRLPTFTPEEIALVKGSNDFYGMNHYTANYVKHRDGEAPADDFLGNLELHFWNYRGDCIGPETQSTWLRPCAPGFRDLLVWLSKRYGFPRMYVTENGTSIKGENDMPREKILEDDFRAQYYDDYVKAMADASRLDGVDVHGYFAWSLLDNFEWAEGYETRFGVTYVDYEHDQKRYPKKSAQHLAPLFDSLIRKEDPKVESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C7YRD4</accession>
    <name>C7YRD4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SDG2122</name>
        <name evidence="3" type="ORF">NECHADRAFT_106131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051150.1">
        <property type="nucleotide sequence ID" value="XM_003051104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YRD4"/>
    <dbReference type="STRING" id="660122.C7YRD4"/>
    <dbReference type="GeneID" id="9667845"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_106131"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_106131"/>
    <dbReference type="eggNOG" id="KOG1337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044629_0_0_1"/>
    <dbReference type="InParanoid" id="C7YRD4"/>
    <dbReference type="OMA" id="AWYRSRC"/>
    <dbReference type="OrthoDB" id="441812at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF76">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="24"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU45437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="499" mass="55618" checksum="F01311D7EDE21616" modified="2009-10-13" version="1">MASSQPLSIASFPAWARLNDVDFTNAELRETDVKGIGLVAARDLKTTTKTTAQPTKETTSNANENGDDLSLLRIPHDLVLSAAAIEEYTKVDQNFRQLLDVAGHQSTRKDILLYLLTHLILSAKGPSGSRGPASTPWTEYLKFLPRHVPVPTMWSEVERALLQGTSLEAALEAKLAALNNEFDELREKSSGLAFWNSLFWEKETATIQDWILIDALYRSRCLELPRAGDAMVPGLDMANHSHDPTAYYEEDDKDDVVLLLRLGVEVTGGEEVSISYGDKSPAEMLFSYGFIDRDSAAHDLTLPLEALPDDPLGKAKLHIFKAPPTLKLSRSDGKLSWRSPFAYLMCLNEEDGLEFRVLQGKDGGRELKLFWQDQDVTARADDFEVLIEQHPLCQVFRLRVVTVLHEVVSTQLTHLPSEISHDQLDPLRRAGLVREECIRAAETLWEVEASVLESATEALEQQRTHLFADDHVVAYLGSMEVSESGQAHDAPANEEDDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C7YS95</accession>
    <name>C7YS95_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_41697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050923.1">
        <property type="nucleotide sequence ID" value="XM_003050877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YS95"/>
    <dbReference type="FunCoup" id="C7YS95">
        <property type="interactions" value="262"/>
    </dbReference>
    <dbReference type="GeneID" id="9668157"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_41697"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_41697"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="InParanoid" id="C7YS95"/>
    <dbReference type="OMA" id="FTWFRYA"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU45210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="325" mass="35481" checksum="535E245158552969" modified="2009-10-13" version="1">MSCNNKTEEFHISEIPSLHGYVAIVTGGNSGIGHETTLQLAKRGARVYIASRSQDRVNKAISDMKHDAGPLDLHFLKLDLQDLQSVKVTAAEFMSKEPRLDLLINNAGIMACPYELTKDGFEIQWQTCFLSHHALTLSLLPVLLAAVQASGDMNRVRVVNVASDGAFLMGPKSINYDDPNMTSLTGATAPWRRYGHCKQASIIGAKAITDHYRPSGIMAFSVHPGIIKSNLQSYDASFLGILTRTAVKIAPTSTPLDGARTSLFCATSPRAVSAAGLYLIPFGKVDPRANRWLNDDEAVEKLWQLASSQLKRHGFAIEDLPKYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSD8</accession>
    <name>C7YSD8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoporin NUP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_41594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050945.1">
        <property type="nucleotide sequence ID" value="XM_003050899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSD8"/>
    <dbReference type="STRING" id="660122.C7YSD8"/>
    <dbReference type="GeneID" id="9666188"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_41594"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_41594"/>
    <dbReference type="eggNOG" id="ENOG502SIXR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014181_0_0_1"/>
    <dbReference type="InParanoid" id="C7YSD8"/>
    <dbReference type="OMA" id="QGMICED"/>
    <dbReference type="OrthoDB" id="8033832at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU45232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="45771" checksum="ACBD5F7C7F9E49AA" modified="2009-10-13" version="1">MAPLILHNVPDDECYIGDDGIKRPYAMYFNQQDGPQGSTRSRRTVAESGSFGKSNRRSRSRTGTPARSRENPTLAAADKLFGDWVNNQAAAAPAPAVQRKNSGMMQEEAAAQRPVTSTPVEIILRGYRSSTQQYAAISRYEGLAGTILEDYPREPPANQRRYKSELRDPAFTRRRTLTSDERALVNRADGGEHWVKVTFGSSEAGETAIYASPQRILGHLVYAEPYRGHPPAKDEACPDVDNAVPDLSRSQSMPAPTPRTKSFSGMPTSFNSRLLDLSPPHSQTSSLTMDTGTISQSTATVTEPLPQSTTTGIEPIEIQDEDSVFCRRIPTARRATLLPAEQALLPQQTVMQRLVNAIPFVKWFGGSMIGNEVPRTETGEFDWTRASLYWKLIWWLDATFGLFSGDVLNADKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7YSH3</accession>
    <name>C7YSH3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pectate lyase C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NECHADRAFT_80736</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003051351.1">
        <property type="nucleotide sequence ID" value="XM_003051305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YSH3"/>
    <dbReference type="GeneID" id="9666203"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_80736"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_80736"/>
    <dbReference type="eggNOG" id="ENOG502QW7I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016764_1_1_1"/>
    <dbReference type="InParanoid" id="C7YSH3"/>
    <dbReference type="OMA" id="GIHSMGT"/>
    <dbReference type="OrthoDB" id="302705at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052063">
        <property type="entry name" value="Polysaccharide_Lyase_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42970">
        <property type="entry name" value="PECTATE LYASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42970:SF1">
        <property type="entry name" value="PECTATE LYASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002986468" description="Pectate lyase C" evidence="4">
        <location>
            <begin position="19"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="339"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="364"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEU45638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="41940" checksum="1B456FBA413B7410" modified="2009-10-13" version="1">MKLSLSLLTLAATSAVQAAVPAFPGAEGFGKDAIGGRNGGEVYKPNRIVVFDVGGIIKITGRMVVSKNVYIAGQTAPGGGIVVYGNGWSFSNANDAIVRYITIRMGRGGTSGKDAITIADGKNMIFDHVSASWGRDETFSINGAVSKVTIQDTIIAQGLVSHSCGGLMQTDGGVSLFRNLYIDNKTRNPKVKGVNDFQNNVIYNWGGGGGYIAGGSDGDSYVNIMNNYFISGPHTSVTAFTRGNANFHAYVKNNFYDSNRNGKLDGSALCESATCYSSMDIVKTPYDYPAPATARTAEQALNVVLASVGNSRTRDAVDTGLVEEVKTYGKKGSQISDESDFGGVGTIASGKAPTDTDGDGIPDEWEKKNGLNPNDKSDGMKIASNGYTNLENYVNSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C7YTB3</accession>
    <name>C7YTB3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_100462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698899">
        <property type="protein sequence ID" value="EEU45004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050717.1">
        <property type="nucleotide sequence ID" value="XM_003050671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YTB3"/>
    <dbReference type="GeneID" id="9668493"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_100462"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_100462"/>
    <dbReference type="eggNOG" id="ENOG502QRGR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032158_1_1_1"/>
    <dbReference type="InParanoid" id="C7YTB3"/>
    <dbReference type="OMA" id="GSMPVCH"/>
    <dbReference type="OrthoDB" id="5402974at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031563">
        <property type="entry name" value="MOT1/MOT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31970:SF9">
        <property type="entry name" value="MOLYBDATE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16983">
        <property type="entry name" value="MFS_MOT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU45004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="47545" checksum="1B43DA9087CE2AD9" modified="2009-10-13" version="1">MAPSWLSDLRRLNRNNLATVRAAPWAEISGSLGDLGTLLPLMIALAAQGSIHLGTTLVFSGLFNILTGVFYGIPLPVQPMKAIASAAISNGSAMSVVTAAGQWVGAAVFIMSVTGLLRWVVRVVPIPVVKGIQLGAGLSLILGAGSSLLQPLHWVHPALDNRIWALVAFLALIGTQKLSRFPYALLFFVIALLLAFVQVLMSQQSLPWFHVWHPQFVMPRWVGKDDSPALWMAIGQLPLTTLNSIIAVSALSQDLLPDIPTPSVGSIGISVALMNLTSTWFGGMPVCHGAGGLAAQYRFGARSGASIIILGLFKLIMGLVFGETLVDLLRHYPKSLLGIMVIAAGLELAKVGQSLNQGASDLWQTAARQDVRRHRDLSDEERTERWTVMLMTTAGILAFRNDAVGFLAGMLCHGAYRLSERLAKWHSSRGIFTSERDPLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C7YTC6</accession>
    <name>C7YTC6_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_48632</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049936.1">
        <property type="nucleotide sequence ID" value="XM_003049890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YTC6"/>
    <dbReference type="STRING" id="660122.C7YTC6"/>
    <dbReference type="GeneID" id="9675094"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_48632"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_48632"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020639_1_1_1"/>
    <dbReference type="InParanoid" id="C7YTC6"/>
    <dbReference type="OMA" id="ERYEMRM"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF104">
        <property type="entry name" value="CYTOCHROME B2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="4">
        <location>
            <begin position="4"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="5">
        <location>
            <begin position="100"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU44223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="467" mass="50796" checksum="ABECDEAF479DA4A0" modified="2009-10-13" version="1">MAQLTTISIGELSRHFQDDNGWMALNGVIWDFSNFADKHPSGRDIIQQHLGKDGSQAYNEIHSSGMVLRYLGEERKVGVMMEQVEHDVSKKSTDKTANMPGLSSLTHLSQFEQVAKHTLSEKAWVYIFSATEDGISHAANTAYHQRVIFRPKVLRGVGQVDISTSFLGQQLSCPILVAPTSSIKLTHPDSEGAMARASQVSGVPPIIPSMGSYSVAEVIESLEPSYPFFMQLYIHRNRAETRRLLDDACRLGAKAIIVTVDLPVLSKRETSTSASLGGERARDKSTVAPQQAPTPANTIIDADLNWQDIKWIRDTTNLPVLIKGVQSAEDAKQGLAIGCAGIYLSNHGGRALDAAPPATLVLLEIQKTCPEILKQMEVVVDGGFRRGSEVLKAICLGATVVCLGRPFLYALAYGEEGAILLKEELKTAMQLLGVVNLKQADLGYLNTSRLERLLPLPVTDGAGLSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C7YTI4</accession>
    <name>C7YTI4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NECHADRAFT_49244</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EMC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050338.1">
        <property type="nucleotide sequence ID" value="XM_003050292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YTI4"/>
    <dbReference type="FunCoup" id="C7YTI4">
        <property type="interactions" value="186"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YTI4"/>
    <dbReference type="GeneID" id="9675123"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_49244"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_49244"/>
    <dbReference type="eggNOG" id="KOG3060">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052388_0_0_1"/>
    <dbReference type="InParanoid" id="C7YTI4"/>
    <dbReference type="OMA" id="LMEMLFY"/>
    <dbReference type="OrthoDB" id="124397at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001208">
        <property type="entry name" value="Tetratricopeptide repeat domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039856">
        <property type="entry name" value="EMC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055217">
        <property type="entry name" value="TPR_EMC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12760">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22890">
        <property type="entry name" value="TPR_EMC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="EMC2 TPR-like" evidence="5">
        <location>
            <begin position="105"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="160"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEU44625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="324" mass="36154" checksum="AB4D658D698DC5BC" modified="2009-10-13" version="1">MAPSLLQPQGHLSPTEALQLAQQAPIILKNNPRAFSASPLVSLFTATETADLWTIYENLLLSCLRTGDDESAHQVLERLVLRFGDQNERVMALKGLVKEAEATNNNELTQVLKEYEDILEEDGTNIPIAKRRVALLRSMGKTPEAISSLIWLLDFNPTDAEAWGELADLYLSQGLYSQAIYALEEVLVLVPNAWNMHARLGEVSLMAANETTDGFPQKFLANSVKRFCRSIELCEDYLRGYYGLKKVTDKLLAESAKLKKHSEGDEFSLPDQATIEKLNQAATKKLAEIVRRYGAQEPLWQGYNADEIAAARDLLDKSSSEVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C7YTS6</accession>
    <name>C7YTS6_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pectate lyase</fullName>
            <ecNumber evidence="10">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_106365</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the polysaccharide lyase 3 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="10"/>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050385.1">
        <property type="nucleotide sequence ID" value="XM_003050339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YTS6"/>
    <dbReference type="STRING" id="660122.C7YTS6"/>
    <dbReference type="GeneID" id="9674795"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_106365"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_106365"/>
    <dbReference type="eggNOG" id="ENOG502QSM3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044863_3_1_1"/>
    <dbReference type="InParanoid" id="C7YTS6"/>
    <dbReference type="OMA" id="DADHPCV"/>
    <dbReference type="OrthoDB" id="441042at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004898">
        <property type="entry name" value="Pectate_lyase_PlyH/PlyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407:SF9">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03211">
        <property type="entry name" value="Pectate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU44672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="219" mass="23349" checksum="A8ACB2D304749224" modified="2009-10-13" version="1">MACLGYTGGVPNPTDHISNSKVIEVKAGQVYDGKWAKYDRGSGACKGQNEGGDKDAVFLLHEGATLKNVIIGKDQSEGVHCKGHCTLEFVWFEDVCEDAISIKEDKAGKESWIIGGGAYHASDKVVQHNGCGTVNIINFYVEDYGKLYRSCGNCSKQCKRNVYIEGVTAKNGGELAGINANYGDTATLKNVCADTKQKCTMYNGCAGGCEPKKIGACPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C7YTX1</accession>
    <name>C7YTX1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_63523</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050031.1">
        <property type="nucleotide sequence ID" value="XM_003049985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YTX1"/>
    <dbReference type="STRING" id="660122.C7YTX1"/>
    <dbReference type="GeneID" id="9674816"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_63523"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_63523"/>
    <dbReference type="eggNOG" id="KOG1257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011405_5_2_1"/>
    <dbReference type="InParanoid" id="C7YTX1"/>
    <dbReference type="OMA" id="YPNMVVQ"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000182">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF32">
        <property type="entry name" value="NADP-DEPENDENT MALIC ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="9">
        <location>
            <begin position="98"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="8">
        <location>
            <begin position="288"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEU44318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="599" mass="67321" checksum="96120C4AFE320D4C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C7YU70</accession>
    <name>C7YU70_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNase1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_101640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050462.1">
        <property type="nucleotide sequence ID" value="XM_003050416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YU70"/>
    <dbReference type="STRING" id="660122.C7YU70"/>
    <dbReference type="GeneID" id="9674862"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_101640"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_101640"/>
    <dbReference type="eggNOG" id="ENOG502RJA7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120092_0_0_1"/>
    <dbReference type="InParanoid" id="C7YU70"/>
    <dbReference type="OMA" id="PCNNAYY"/>
    <dbReference type="OrthoDB" id="3513524at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002987572" description="DNase1 protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU44749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="18100" checksum="732377C5FEBB18B2" modified="2009-10-13" version="1">MKFATAIMAFVASATYAAAAQVTFKTLDDKVRTVYFTSDPGYASIDPVVVSNKEDTTVQFPDKYIGNYWAVVKGGKNTGTGMLGEVTFGGWMGKTYFDVSAIVVPGDTNNVKQMYPAKSMTPDSGCEEFPCDNAYYLPDDEQTKVTDETHLITTLGAGSIELPKAAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C7YUG9</accession>
    <name>C7YUG9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NECHADRAFT_84918</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOP16 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050124.1">
        <property type="nucleotide sequence ID" value="XM_003050078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YUG9"/>
    <dbReference type="FunCoup" id="C7YUG9">
        <property type="interactions" value="260"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YUG9"/>
    <dbReference type="GeneID" id="9665562"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84918"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84918"/>
    <dbReference type="eggNOG" id="KOG4771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078857_0_0_1"/>
    <dbReference type="InParanoid" id="C7YUG9"/>
    <dbReference type="OMA" id="MQQTEAD"/>
    <dbReference type="OrthoDB" id="285729at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019002">
        <property type="entry name" value="Ribosome_biogenesis_Nop16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243">
        <property type="entry name" value="HSPC111 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09420">
        <property type="entry name" value="Nop16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="113"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEU44411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="216" mass="24112" checksum="C45319D89DC282C4" modified="2009-10-13" version="1">MGRELQKKKRRSGRQPVRQSNRTKKILNPRGNDAIAKNWNKNETLAQNYRRLGLLARLKAPTGGTEKLLGATTTRTSSKDPFGIATVENAIVSEARVERDADGKIVRILGHAKPNPLNDPLNDLDRDSDDEEPTEEWGGIEDGADATDVVKSLIEESRAPVEKKPRHQSSREKEWLDKLVAKYGDDTAAMAKDKKLNPMQQTAADIAKRIRKLNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C7YUP3</accession>
    <name>C7YUP3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mmc1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NECHADRAFT_84992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698900">
        <property type="protein sequence ID" value="EEU44842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003050555.1">
        <property type="nucleotide sequence ID" value="XM_003050509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YUP3"/>
    <dbReference type="GeneID" id="9674942"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84992"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84992"/>
    <dbReference type="eggNOG" id="ENOG502RY8K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023613_1_0_1"/>
    <dbReference type="InParanoid" id="C7YUP3"/>
    <dbReference type="OMA" id="WAERAHT"/>
    <dbReference type="OrthoDB" id="5319015at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056196">
        <property type="entry name" value="Mmc1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38644">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38644:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23868">
        <property type="entry name" value="Mmc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23867">
        <property type="entry name" value="Mmc1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mmc1 C-terminal" evidence="2">
        <location>
            <begin position="381"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU44842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="641" mass="71261" checksum="9F94FEDADD7E9659" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWB1</accession>
    <name>C7YWB1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein CSN12 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NECHADRAFT_98563</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN12 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU43930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049643.1">
        <property type="nucleotide sequence ID" value="XM_003049597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWB1"/>
    <dbReference type="FunCoup" id="C7YWB1">
        <property type="interactions" value="891"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YWB1"/>
    <dbReference type="GeneID" id="9677436"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_98563"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_98563"/>
    <dbReference type="eggNOG" id="KOG2688">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031567_1_0_1"/>
    <dbReference type="InParanoid" id="C7YWB1"/>
    <dbReference type="OMA" id="INRMFTL"/>
    <dbReference type="OrthoDB" id="10252687at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000366">
        <property type="entry name" value="COP9 signalosome complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF0">
        <property type="entry name" value="PCI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="250"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00073854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEU43930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="453" mass="51842" checksum="96684C860FFC3619" modified="2009-10-13" version="1">MNTLFEQFAQAHALRNGYKLAQTLSPVPPPDDPQRLLAVWRSTNSHSVKGDIKHFIKSNTSHRQKLDHDEVTGWVDVYQSYWKAIGEILAGESGKSTWTKVYEAWKELTSVLIRGYNSHGFEAWTIPSLYMVGKYLRLFAIKSDEERQSISSAPGASLMDDDFDPQTEGQLQLRDCEGHLKRIFSLCLNDRAPLEESRKWGIYFVINLLFKTYFKLNSASLSRTIIKTLSVYNDKGDMPALEMFPKSQRVTFKFYEGVLRFLEEDYLAAESHLNEAWNLCHKDAITQSERILTYLIPCRLITSHVLPTKTLLENYPRLQELFLPLARCIKSGNLKEFDEALKKGEDEFVKRRIYLTLERGRDIALRNLLRKVFIAGGYDEPKEADTAPVRRTRIPVTEFQAAISMSSGQMIEGDEVECLLANMIYKELMKGYIARERGIVVLSKKGAFPGTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWB8</accession>
    <name>C7YWB8_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NECHADRAFT_102984</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG698901">
        <property type="protein sequence ID" value="EEU44152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049865.1">
        <property type="nucleotide sequence ID" value="XM_003049819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWB8"/>
    <dbReference type="FunCoup" id="C7YWB8">
        <property type="interactions" value="493"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YWB8"/>
    <dbReference type="GeneID" id="9677440"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_102984"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_102984"/>
    <dbReference type="eggNOG" id="KOG0064">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007587_1_1_1"/>
    <dbReference type="InParanoid" id="C7YWB8"/>
    <dbReference type="OMA" id="IHDMYLD"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF67">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="173"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="527"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="747"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEU44152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="810" mass="91522" checksum="8B4994C5543A15FA" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C7YWT3</accession>
    <name>C7YWT3_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_45060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049174.1">
        <property type="nucleotide sequence ID" value="XM_003049128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YWT3"/>
    <dbReference type="STRING" id="660122.C7YWT3"/>
    <dbReference type="GeneID" id="9677066"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45060"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45060"/>
    <dbReference type="eggNOG" id="KOG0740">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004471_6_3_1"/>
    <dbReference type="InParanoid" id="C7YWT3"/>
    <dbReference type="OMA" id="DMEYVDW"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="1">
        <location>
            <begin position="317"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU43461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="501" mass="55899" checksum="5F60EF49A8E8DB8E" modified="2009-10-13" version="1">MPIVHRWDTLRSLCEGSGEEPATEPATQLMDFLRPILAPQVDSLANTRKTGNVRFEDLWQIFAPHEFVVTSFYDVEAVCRVAKYELTEPPLDPPYWTVTLEYLDWNGHRCGYATTKVVISHFAGSQRVVSLPVYPLSFHSDATGMRKRILERGRVFESLRGYHFRACSGTKVLLERPEARPVGGGVIIDAFAYYLTNDIVKPGLTPLGPDTSKKDAPAEGNAEMTAKTSDFSLKRPDNLEALSDYQCLLANPWVKGLDLKTKEWAQFFVDDLSPIAWNDEAFTNLVLPGSVKQLAWEFVENKALANNFDDFIQDKGRGLIILMFGPPGVGKTYTAEAVAEQAHVPLYAMSAGELGTVPSDVETALSRALTLCGLWNAMLLLDEADVFLSARTDSDLTRNELVAVFLTKLEYYTGICFLTTNRITSIDPAFESRVHLFLPYKDLTVAARRKVWENFINRTGCDRSDISSENLDELSKISLNGREIKNLIKSAHLLSLKNGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXA1</accession>
    <name>C7YXA1_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_82944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aegerolysin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049266.1">
        <property type="nucleotide sequence ID" value="XM_003049220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXA1"/>
    <dbReference type="STRING" id="660122.C7YXA1"/>
    <dbReference type="GeneID" id="9676935"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_82944"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_82944"/>
    <dbReference type="HOGENOM" id="CLU_1796088_0_0_1"/>
    <dbReference type="InParanoid" id="C7YXA1"/>
    <dbReference type="OrthoDB" id="2727348at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019836">
        <property type="term" value="P:symbiont-mediated hemolysis of host erythrocyte"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009413">
        <property type="entry name" value="Aegerolysin-typ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06355">
        <property type="entry name" value="Aegerolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU43553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="146" mass="16455" checksum="7CE2CBA06E711202" modified="2009-10-13" version="1">MGWNQWALFRFSNKTYDDTLKLVFPNKGDHWGWPFADTQDSGTRNRITYDEIQDKEIGPQTSYAYGQTGKQNEWAGMEGTVDIWTKAAAGISGQKIARVYYSCPWSGKNQFTITDIASGWNVTHWGADYDGDALGSITIEEVGIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C7YXT1</accession>
    <name>C7YXT1_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NECHADRAFT_45012</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698902">
        <property type="protein sequence ID" value="EEU43640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003049353.1">
        <property type="nucleotide sequence ID" value="XM_003049307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YXT1"/>
    <dbReference type="GeneID" id="9666409"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_45012"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_45012"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_4_1_1"/>
    <dbReference type="InParanoid" id="C7YXT1"/>
    <dbReference type="OMA" id="FALQEMH"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEU43640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="492" mass="55340" checksum="F128DECD8BEA637B" modified="2009-10-13" version="1">MPSLVSLEELTATKVLVTFLTIVIIVPRVFTVIKNAFSPISSIPGPLLNKLSPWPLTIATIKGTSHHFARSLHEKYGPIVVLAPGMIAVADTKEIKRIIQTEDWTKSEAIYGNFRQDPQRPTLLAYTDKKAYSKRKRMLSSMFGIKYIRSMEPIMMTCVEAAVRQLNKFCDEGSQGAAVVDMQHLIHSLAIDVIGITTFGGSLHVVDNGSHPLPSRLKAGLRIAGLMQLIPWIRFIPFLPTRDPYVDKFTYDIVDGRRQELESSQHSDLLQKLVEASDDSPGSDFRTSDVQDESVVMLTAGSETTANAELFTLMMLLKNPEVMNKLVDEVDQWYPPSEPDRQTDCGYSQAGMAYLQACIDETMRLVPGQATGSPRETSKDDVVLGYRIPAGTTVFPNTQESHMQDAHWEEPQKFVPERWLEAQAANMPYWPFSAGSRVCIGKHFAFQEMHLTLVTLLRKFKFEYVDGQDESTVFRVAQQLKAESYRMKVSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYI1</accession>
    <name>C7YYI1_FUSV7</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_83698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048906.1">
        <property type="nucleotide sequence ID" value="XM_003048860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYI1"/>
    <dbReference type="GeneID" id="9665494"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_83698"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_83698"/>
    <dbReference type="HOGENOM" id="CLU_1384483_0_0_1"/>
    <dbReference type="InParanoid" id="C7YYI1"/>
    <dbReference type="OrthoDB" id="5010985at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002988676" evidence="1">
        <location>
            <begin position="19"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU43193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="197" mass="22762" checksum="4B1E932A749E523E" modified="2009-10-13" version="1">MKWYSLLSASFLLGTVIAADPVHQVPEPITYRLIVTANGTIKDIDDIYLSSDEEGTVGIFGTDREPILIHDTKPGKKSGQFYFDTRPGDELFHGLTLLRWQGVMNLKDTLHPHRFRIRNDTGTQYLPDRYSWNEFWFTEGENGMKELFWGAKGDHPGWVAVPLIDATYIIKWYDETSSYMVAKPWEPVKIYLQPFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C7YYU9</accession>
    <name>C7YYU9_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylglucosamine-induced protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NECHADRAFT_46754</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698903">
        <property type="protein sequence ID" value="EEU43061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048774.1">
        <property type="nucleotide sequence ID" value="XM_003048728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YYU9"/>
    <dbReference type="FunCoup" id="C7YYU9">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="GeneID" id="9665969"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_46754"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_46754"/>
    <dbReference type="eggNOG" id="ENOG502S263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075862_0_0_1"/>
    <dbReference type="InParanoid" id="C7YYU9"/>
    <dbReference type="OMA" id="YHDWEDL"/>
    <dbReference type="OrthoDB" id="498286at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022036">
        <property type="entry name" value="DUF3605"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020:SF2">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12239">
        <property type="entry name" value="DUF3605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEU43061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="23747" checksum="DDB41FBF943D201A" modified="2009-10-13" version="1">MGENPPEESPFPLTEVDKWILSQTDEEFKKHDWEDLKGIIANNLSVLKRKPSDLRRYMKWTSETKAEYGSMTNYLLANRLPKAWGQPPFTPVSDVPFKDPSDYHVLINDWPYGLDPEIRHIVVWLRTTIPTDPETGDMTPESRALVKAFVKEYFADTLGPDGENRVLWFKNWVALQSVRALEHIHVLVRNVDDDTIERWTGERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZG4</accession>
    <name>C7YZG4_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">A-kinase anchor protein 7-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NECHADRAFT_84021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048513.1">
        <property type="nucleotide sequence ID" value="XM_003048467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZG4"/>
    <dbReference type="STRING" id="660122.C7YZG4"/>
    <dbReference type="GeneID" id="9667590"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_84021"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_84021"/>
    <dbReference type="eggNOG" id="KOG2814">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038379_0_0_1"/>
    <dbReference type="InParanoid" id="C7YZG4"/>
    <dbReference type="OMA" id="LYPFCVK"/>
    <dbReference type="OrthoDB" id="277832at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009210">
        <property type="entry name" value="ASCC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360:SF1">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027019">
        <property type="entry name" value="Euk_LigT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A-kinase anchor protein 7-like phosphoesterase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEU42800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="242" mass="26762" checksum="3B87A730CC9EAF31" modified="2009-10-13" version="1">MPPKPARAAPTHFVCIPLAGPQLYRSLAAFEADVTSPMSFGVPPDAVRPPGTMHLTLGVMSLKDDGIEQATEVLKSLRLRDMLSNARKAFLQSRAVQMGLASAENSSTAREGPLSITLQGLHAMQTPSKTSVLYAPPVDTEGILYKFCEQIKNTFQEAGLMAEDSRPLLLHATVINTIYIKNGRGRRREKLTIDAQDMVSRYDDYVWMENMPLEKVTLCRMGAKKIEGTDDEAYEVEAEVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZN5</accession>
    <name>C7YZN5_FUSV7</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphinganine-1-phosphate aldolase</fullName>
            <ecNumber evidence="14">4.1.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Sphingosine-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">NECHADRAFT_63095</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.27" evidence="14"/>
    <dbReference type="EMBL" id="GG698904">
        <property type="protein sequence ID" value="EEU42639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048352.1">
        <property type="nucleotide sequence ID" value="XM_003048306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7YZN5"/>
    <dbReference type="FunCoup" id="C7YZN5">
        <property type="interactions" value="753"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7YZN5"/>
    <dbReference type="GeneID" id="9667429"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_63095"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_63095"/>
    <dbReference type="eggNOG" id="KOG1383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028929_1_0_1"/>
    <dbReference type="InParanoid" id="C7YZN5"/>
    <dbReference type="OMA" id="AFWQLRG"/>
    <dbReference type="OrthoDB" id="10254570at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
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        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF6">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE 1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7 16 17" id="KW-0663">Pyridoxal phosphate</keyword>
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    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="16">
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            <position position="360"/>
        </location>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEU42639.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="571" mass="62841" checksum="DF3C8008B4987E13" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C7YZQ5</accession>
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        <name evidence="2" type="ORF">NECHADRAFT_63110</name>
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        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
        <name type="synonym">Fusarium solani subsp. pisi</name>
        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
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    </reference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="321"/>
        </location>
    </feature>
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        <location>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEU42649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="673" mass="75153" checksum="5697B71C37FBDCA2" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">NECHADRAFT_106105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)</name>
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        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
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                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
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            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
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    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_106105"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEU42216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005206"/>
        </source>
    </evidence>
    <sequence length="113" mass="12474" checksum="A20FD1165AA61945" modified="2009-10-13" version="1">MLSTFLLLLLATTSLAMPQPTAQPTPQPTPELLKRNATTNSTRHDCLRNCTSQCGHGGVCDLVCSILKCPPNMKRADLSGEFEEVARRSEEEKEEEEEDGFEDVEVVETGHVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>C7Z0R9</accession>
    <name>C7Z0R9_FUSV7</name>
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        <recommendedName>
            <fullName evidence="9">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NECHADRAFT_68989</name>
    </gene>
    <organism evidence="10 11">
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        <dbReference type="NCBI Taxonomy" id="660122"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium solani species complex</taxon>
            <taxon>Fusarium vanettenii</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000618" last="E1000618">
            <title>The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.</title>
            <authorList>
                <person name="Coleman J.J."/>
                <person name="Rounsley S.D."/>
                <person name="Rodriguez-Carres M."/>
                <person name="Kuo A."/>
                <person name="Wasmann C.C."/>
                <person name="Grimwood J."/>
                <person name="Schmutz J."/>
                <person name="Taga M."/>
                <person name="White G.J."/>
                <person name="Zhou S."/>
                <person name="Schwartz D.C."/>
                <person name="Freitag M."/>
                <person name="Ma L.J."/>
                <person name="Danchin E.G."/>
                <person name="Henrissat B."/>
                <person name="Coutinho P.M."/>
                <person name="Nelson D.R."/>
                <person name="Straney D."/>
                <person name="Napoli C.A."/>
                <person name="Barker B.M."/>
                <person name="Gribskov M."/>
                <person name="Rep M."/>
                <person name="Kroken S."/>
                <person name="Molnar I."/>
                <person name="Rensing C."/>
                <person name="Kennell J.C."/>
                <person name="Zamora J."/>
                <person name="Farman M.L."/>
                <person name="Selker E.U."/>
                <person name="Salamov A."/>
                <person name="Shapiro H."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Lamers C."/>
                <person name="Grigoriev I.V."/>
                <person name="Geiser D.M."/>
                <person name="Covert S.F."/>
                <person name="Temporini E."/>
                <person name="Vanetten H.D."/>
            </authorList>
            <dbReference type="PubMed" id="19714214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000618"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG698905">
        <property type="protein sequence ID" value="EEU42431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003048144.1">
        <property type="nucleotide sequence ID" value="XM_003048098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C7Z0R9"/>
    <dbReference type="FunCoup" id="C7Z0R9">
        <property type="interactions" value="1451"/>
    </dbReference>
    <dbReference type="STRING" id="660122.C7Z0R9"/>
    <dbReference type="GeneID" id="9671947"/>
    <dbReference type="KEGG" id="nhe:NECHADRAFT_68989"/>
    <dbReference type="VEuPathDB" id="FungiDB:NECHADRAFT_68989"/>
    <dbReference type="eggNOG" id="KOG2020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011906_0_0_1"/>
    <dbReference type="InParanoid" id="C7Z0R9"/>
    <dbReference type="OMA" id="WAFKHNN"/>
    <dbReference type="OrthoDB" id="27218at2759"/>
    <dbReference type="Proteomes" id="UP000005206">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071528">
        <property type="term" value="P:tRNA re-export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000490">
        <property type="entry name" value="CRM1p Major karyopherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    